C4ORF46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small, conserved protein of unknown function that is expressed in a variety of tissues. There are pseudogenes for this gene on chromosomes 6, 8, 16, and X. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.30197194
2CENP-A containing nucleosome assembly (GO:0034080)5.28013427
3establishment of integrated proviral latency (GO:0075713)5.10039047
4DNA strand elongation involved in DNA replication (GO:0006271)4.91863425
5protein localization to kinetochore (GO:0034501)4.81289385
6DNA strand elongation (GO:0022616)4.74771724
7telomere maintenance via semi-conservative replication (GO:0032201)4.59678725
8mitotic metaphase plate congression (GO:0007080)4.45491062
9DNA unwinding involved in DNA replication (GO:0006268)4.44277147
10mitotic sister chromatid segregation (GO:0000070)4.41419081
11DNA replication checkpoint (GO:0000076)4.37058389
12sister chromatid segregation (GO:0000819)4.36475380
13protein localization to chromosome, centromeric region (GO:0071459)4.32798845
14histone exchange (GO:0043486)4.28928745
15DNA ligation (GO:0006266)4.21233477
16DNA replication-independent nucleosome assembly (GO:0006336)4.19415963
17DNA replication-independent nucleosome organization (GO:0034724)4.19415963
18mitotic recombination (GO:0006312)4.08171897
19nuclear pore complex assembly (GO:0051292)4.03896755
20telomere maintenance via recombination (GO:0000722)4.01602152
21kinetochore organization (GO:0051383)4.00272796
22metaphase plate congression (GO:0051310)3.96136347
23establishment of viral latency (GO:0019043)3.94837204
24spindle checkpoint (GO:0031577)3.87137770
25mitotic chromosome condensation (GO:0007076)3.82442971
26nuclear pore organization (GO:0006999)3.81785130
27negative regulation of chromosome segregation (GO:0051985)3.76698148
28negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.76228655
29negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.76228655
30negative regulation of mitotic sister chromatid segregation (GO:0033048)3.76228655
31negative regulation of mitotic sister chromatid separation (GO:2000816)3.76228655
32negative regulation of sister chromatid segregation (GO:0033046)3.76228655
33mitotic spindle checkpoint (GO:0071174)3.75512475
34purine nucleobase biosynthetic process (GO:0009113)3.69281510
35DNA double-strand break processing (GO:0000729)3.68711090
36DNA replication initiation (GO:0006270)3.66323506
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.64380623
38IMP biosynthetic process (GO:0006188)3.60868626
39proteasome assembly (GO:0043248)3.60241686
40double-strand break repair via nonhomologous end joining (GO:0006303)3.58344839
41non-recombinational repair (GO:0000726)3.58344839
42regulation of mitotic metaphase/anaphase transition (GO:0030071)3.55685680
43regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.55685680
44mitotic spindle assembly checkpoint (GO:0007094)3.55339294
45DNA topological change (GO:0006265)3.55195418
46regulation of chromosome segregation (GO:0051983)3.54496532
47spindle assembly checkpoint (GO:0071173)3.54131044
48telomere maintenance via telomere lengthening (GO:0010833)3.47939039
49nucleotide-excision repair, DNA gap filling (GO:0006297)3.46760716
50kinetochore assembly (GO:0051382)3.46248276
51regulation of mitotic sister chromatid segregation (GO:0033047)3.43429691
52regulation of sister chromatid segregation (GO:0033045)3.43429691
53regulation of mitotic sister chromatid separation (GO:0010965)3.43429691
54mitotic nuclear envelope disassembly (GO:0007077)3.42710798
55negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42560187
56mitotic sister chromatid cohesion (GO:0007064)3.41062195
57nucleobase biosynthetic process (GO:0046112)3.40253405
58ATP-dependent chromatin remodeling (GO:0043044)3.40066800
59establishment of chromosome localization (GO:0051303)3.39635619
60regulation of helicase activity (GO:0051095)3.39422793
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.38410957
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34490273
63DNA replication-dependent nucleosome organization (GO:0034723)3.33820209
64DNA replication-dependent nucleosome assembly (GO:0006335)3.33820209
65regulation of centriole replication (GO:0046599)3.31950271
66ribosome assembly (GO:0042255)3.26084382
67DNA catabolic process, exonucleolytic (GO:0000738)3.22769430
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.21393975
69regulation of mitotic spindle checkpoint (GO:1903504)3.21393975
70L-serine metabolic process (GO:0006563)3.21153802
71IMP metabolic process (GO:0046040)3.18880938
72DNA damage response, detection of DNA damage (GO:0042769)3.16834852
73chromosome segregation (GO:0007059)3.16122456
74membrane disassembly (GO:0030397)3.15244542
75nuclear envelope disassembly (GO:0051081)3.15244542
76negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13786287
77negative regulation of ligase activity (GO:0051352)3.13786287
78somatic diversification of immune receptors via somatic mutation (GO:0002566)3.11487155
79somatic hypermutation of immunoglobulin genes (GO:0016446)3.11487155
80regulation of double-strand break repair via homologous recombination (GO:0010569)3.08133504
81regulation of sister chromatid cohesion (GO:0007063)3.07806085
82spliceosomal snRNP assembly (GO:0000387)3.06929859
83chromatin assembly or disassembly (GO:0006333)3.06870990
84attachment of spindle microtubules to kinetochore (GO:0008608)3.05556018
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05481547
86heterochromatin organization (GO:0070828)3.04946452
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03777670
88pore complex assembly (GO:0046931)3.03548571
89protein localization to chromosome (GO:0034502)3.02056060
90negative regulation of mitosis (GO:0045839)3.01304218
91regulation of spindle organization (GO:0090224)3.01038915
92microtubule depolymerization (GO:0007019)3.00985594
93negative regulation of DNA-dependent DNA replication (GO:2000104)3.00202769
94positive regulation of chromosome segregation (GO:0051984)2.97014941
95regulation of DNA endoreduplication (GO:0032875)2.95194315
96protein K6-linked ubiquitination (GO:0085020)2.95129825
97formation of translation preinitiation complex (GO:0001731)2.94502132
98telomere organization (GO:0032200)2.94369081
99telomere maintenance (GO:0000723)2.94207747
100termination of RNA polymerase II transcription (GO:0006369)2.93667315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.51579638
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.70918830
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.60951542
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.39688669
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.76102992
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.66598925
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.36437974
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.20913204
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.14906844
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77493857
11AR_21909140_ChIP-Seq_LNCAP_Human2.73853863
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.69034270
13ELK1_19687146_ChIP-ChIP_HELA_Human2.64145070
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.64084947
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58890240
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46785099
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45960562
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.45351842
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.36994314
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.36213554
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.31583714
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30810224
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29609585
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23611189
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21008895
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13034230
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12718164
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12169053
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98977650
30DCP1A_22483619_ChIP-Seq_HELA_Human1.98676745
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96621942
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96523790
33VDR_23849224_ChIP-Seq_CD4+_Human1.96066725
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95069582
35FOXP3_21729870_ChIP-Seq_TREG_Human1.94023475
36TTF2_22483619_ChIP-Seq_HELA_Human1.93848164
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92070362
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91903849
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87770844
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84459175
41XRN2_22483619_ChIP-Seq_HELA_Human1.79090608
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78162154
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66936483
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65064204
45MYC_18940864_ChIP-ChIP_HL60_Human1.60160596
46GABP_19822575_ChIP-Seq_HepG2_Human1.58120823
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57566789
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54487876
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50403233
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48185715
51EWS_26573619_Chip-Seq_HEK293_Human1.43179316
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.42925632
53NANOG_16153702_ChIP-ChIP_HESCs_Human1.40251350
54FUS_26573619_Chip-Seq_HEK293_Human1.39995865
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39357474
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.37392662
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.34612273
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31990412
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27649936
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26827811
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23923406
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22467832
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19583734
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18652317
65CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12589475
66IRF1_19129219_ChIP-ChIP_H3396_Human1.12029447
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09983331
68SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09232981
69SOX17_20123909_ChIP-Seq_XEN_Mouse1.06435562
70ZNF274_21170338_ChIP-Seq_K562_Hela1.05557213
71KDM5A_27292631_Chip-Seq_BREAST_Human1.03389878
72IGF1R_20145208_ChIP-Seq_DFB_Human1.01808301
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.01520127
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01395482
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98684360
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97830247
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95164660
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94788581
79YY1_21170310_ChIP-Seq_MESCs_Mouse0.94185872
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92497060
81ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91333102
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86094029
83POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85282443
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81161588
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81153491
86NANOG_21062744_ChIP-ChIP_HESCs_Human0.79974601
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78990162
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76346496
89WT1_19549856_ChIP-ChIP_CCG9911_Human0.75719706
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.75364145
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74417482
92TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74251572
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.74087825
94TFEB_21752829_ChIP-Seq_HELA_Human0.73530365
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72697030
96TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72344257
97NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71609584
98KLF4_18555785_ChIP-Seq_MESCs_Mouse0.69499787
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.68214665
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.68190513

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.14342426
2MP0003693_abnormal_embryo_hatching4.58880101
3MP0003111_abnormal_nucleus_morphology4.13658506
4MP0004957_abnormal_blastocyst_morpholog3.97828184
5MP0008058_abnormal_DNA_repair3.93514149
6MP0003077_abnormal_cell_cycle3.61468517
7MP0008057_abnormal_DNA_replication3.57629024
8MP0008932_abnormal_embryonic_tissue3.24572615
9MP0008007_abnormal_cellular_replicative2.72011592
10MP0009697_abnormal_copulation2.47072130
11MP0003941_abnormal_skin_development2.38091305
12MP0003890_abnormal_embryonic-extraembry2.07557487
13MP0001293_anophthalmia2.06894609
14MP0006292_abnormal_olfactory_placode1.92121421
15MP0008877_abnormal_DNA_methylation1.90643977
16MP0002102_abnormal_ear_morphology1.90576239
17MP0000350_abnormal_cell_proliferation1.87515912
18MP0003567_abnormal_fetal_cardiomyocyte1.85254240
19MP0001730_embryonic_growth_arrest1.83355248
20MP0003718_maternal_effect1.81802608
21MP0003937_abnormal_limbs/digits/tail_de1.76410782
22MP0002938_white_spotting1.71448226
23MP0001529_abnormal_vocalization1.64031277
24MP0001697_abnormal_embryo_size1.60846854
25MP0005380_embryogenesis_phenotype1.60447770
26MP0001672_abnormal_embryogenesis/_devel1.60447770
27MP0003786_premature_aging1.58901919
28MP0002085_abnormal_embryonic_tissue1.57648526
29MP0010030_abnormal_orbit_morphology1.56519792
30MP0002084_abnormal_developmental_patter1.52913217
31MP0009672_abnormal_birth_weight1.51810239
32MP0008789_abnormal_olfactory_epithelium1.47049052
33MP0002751_abnormal_autonomic_nervous1.44816254
34MP0004197_abnormal_fetal_growth/weight/1.44565786
35MP0001286_abnormal_eye_development1.43156827
36MP0006072_abnormal_retinal_apoptosis1.39292062
37MP0002080_prenatal_lethality1.35972844
38MP0002697_abnormal_eye_size1.35631569
39MP0003984_embryonic_growth_retardation1.35446551
40MP0010352_gastrointestinal_tract_polyps1.34469491
41MP0010307_abnormal_tumor_latency1.32037772
42MP0003221_abnormal_cardiomyocyte_apopto1.31357095
43MP0000049_abnormal_middle_ear1.30992078
44MP0002088_abnormal_embryonic_growth/wei1.30932426
45MP0006035_abnormal_mitochondrial_morpho1.23765340
46MP0002233_abnormal_nose_morphology1.22232402
47MP0005394_taste/olfaction_phenotype1.21119735
48MP0005499_abnormal_olfactory_system1.21119735
49MP0002111_abnormal_tail_morphology1.17655102
50MP0000313_abnormal_cell_death1.17150217
51MP0003755_abnormal_palate_morphology1.16191134
52MP0009703_decreased_birth_body1.11657414
53MP0002210_abnormal_sex_determination1.07376676
54MP0003119_abnormal_digestive_system1.06501080
55MP0003136_yellow_coat_color1.06342843
56MP0001188_hyperpigmentation1.06301169
57MP0003121_genomic_imprinting1.05546776
58MP0000372_irregular_coat_pigmentation1.02561916
59MP0002092_abnormal_eye_morphology1.00941561
60MP0001299_abnormal_eye_distance/0.99623706
61MP0000358_abnormal_cell_content/0.99191499
62MP0003806_abnormal_nucleotide_metabolis0.98362988
63MP0003315_abnormal_perineum_morphology0.95822555
64MP0003861_abnormal_nervous_system0.95679067
65MP0004133_heterotaxia0.95448970
66MP0003385_abnormal_body_wall0.94002544
67MP0000537_abnormal_urethra_morphology0.93963302
68MP0001929_abnormal_gametogenesis0.90961271
69MP0005391_vision/eye_phenotype0.89972090
70MP0001145_abnormal_male_reproductive0.89827708
71MP0002086_abnormal_extraembryonic_tissu0.88258168
72MP0000428_abnormal_craniofacial_morphol0.88142071
73MP0000647_abnormal_sebaceous_gland0.87984734
74MP0006054_spinal_hemorrhage0.87451076
75MP0002396_abnormal_hematopoietic_system0.86923257
76MP0003935_abnormal_craniofacial_develop0.85191023
77MP0000653_abnormal_sex_gland0.84762392
78MP0002234_abnormal_pharynx_morphology0.84155773
79MP0003186_abnormal_redox_activity0.80162865
80MP0001346_abnormal_lacrimal_gland0.77998567
81MP0003123_paternal_imprinting0.76673425
82MP0003880_abnormal_central_pattern0.74565954
83MP0001177_atelectasis0.74544136
84MP0000490_abnormal_crypts_of0.74459877
85MP0000432_abnormal_head_morphology0.74436381
86MP0000516_abnormal_urinary_system0.73640901
87MP0005367_renal/urinary_system_phenotyp0.73640901
88MP0005253_abnormal_eye_physiology0.72106589
89MP0001119_abnormal_female_reproductive0.70727186
90MP0002081_perinatal_lethality0.70561520
91MP0002019_abnormal_tumor_incidence0.70560627
92MP0003943_abnormal_hepatobiliary_system0.70255937
93MP0005171_absent_coat_pigmentation0.69981058
94MP0009250_abnormal_appendicular_skeleto0.68959769
95MP0002090_abnormal_vision0.68034739
96MP0002160_abnormal_reproductive_system0.67942415
97MP0002163_abnormal_gland_morphology0.64965187
98MP0002114_abnormal_axial_skeleton0.64780619
99MP0005197_abnormal_uvea_morphology0.62539152
100MP0003942_abnormal_urinary_system0.62052433

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.80336569
2Chromsome breakage (HP:0040012)4.48889156
3Meckel diverticulum (HP:0002245)3.94028293
4Abnormality of chromosome stability (HP:0003220)3.75249720
5Abnormality of the ileum (HP:0001549)3.73949560
6Abnormality of the labia minora (HP:0012880)3.66841481
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.58794840
8Abnormal lung lobation (HP:0002101)3.55534104
9Birth length less than 3rd percentile (HP:0003561)3.38275925
10Colon cancer (HP:0003003)3.35802142
11Abnormality of the preputium (HP:0100587)3.29124216
12Duodenal stenosis (HP:0100867)3.23602944
13Small intestinal stenosis (HP:0012848)3.23602944
14Nephroblastoma (Wilms tumor) (HP:0002667)3.16265072
15Cortical dysplasia (HP:0002539)3.04091764
16Embryonal renal neoplasm (HP:0011794)3.01431122
17Abnormality of the duodenum (HP:0002246)2.87278050
18Reticulocytopenia (HP:0001896)2.86625090
19Increased nuchal translucency (HP:0010880)2.78549976
20Myelodysplasia (HP:0002863)2.62002100
21Triphalangeal thumb (HP:0001199)2.51094211
22Rhabdomyosarcoma (HP:0002859)2.48550107
23Medulloblastoma (HP:0002885)2.47458696
24Abnormality of the carotid arteries (HP:0005344)2.45397816
25Sloping forehead (HP:0000340)2.44358587
26Ectopic kidney (HP:0000086)2.43824242
27Absent radius (HP:0003974)2.38732657
28Acute necrotizing encephalopathy (HP:0006965)2.35517182
29Increased serum pyruvate (HP:0003542)2.34849285
30Abnormality of glycolysis (HP:0004366)2.33711134
31Acute encephalopathy (HP:0006846)2.31492984
32Aplasia involving forearm bones (HP:0009822)2.24959958
33Absent forearm bone (HP:0003953)2.24959958
34Multiple enchondromatosis (HP:0005701)2.21197500
35Septo-optic dysplasia (HP:0100842)2.21156953
36Volvulus (HP:0002580)2.20649562
37Ependymoma (HP:0002888)2.18732300
38Increased hepatocellular lipid droplets (HP:0006565)2.17846664
39Abnormality of the anterior horn cell (HP:0006802)2.15365458
40Degeneration of anterior horn cells (HP:0002398)2.15365458
41Horseshoe kidney (HP:0000085)2.12502920
42Neoplasm of the colon (HP:0100273)2.12221512
43Intestinal atresia (HP:0011100)2.10100482
44Clubbing of toes (HP:0100760)2.08169031
45Abnormality of the septum pellucidum (HP:0007375)2.05484535
46Hypoplastic pelvis (HP:0008839)2.04374499
47Abnormal mitochondria in muscle tissue (HP:0008316)2.01152017
48Absent septum pellucidum (HP:0001331)2.00885716
49Microvesicular hepatic steatosis (HP:0001414)1.99195569
50Abnormality of methionine metabolism (HP:0010901)1.97582618
51Hyperglycinemia (HP:0002154)1.97085368
52Supernumerary spleens (HP:0009799)1.92847863
53Shoulder girdle muscle weakness (HP:0003547)1.90850741
54Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90303825
55Increased CSF lactate (HP:0002490)1.86265418
56Postnatal microcephaly (HP:0005484)1.84932422
57Spastic diplegia (HP:0001264)1.84376627
58Progressive macrocephaly (HP:0004481)1.83744455
59Embryonal neoplasm (HP:0002898)1.83667993
60Stenosis of the external auditory canal (HP:0000402)1.82494403
61Glioma (HP:0009733)1.82100278
62Patellar aplasia (HP:0006443)1.81890587
63Agnosia (HP:0010524)1.79266362
64Irregular epiphyses (HP:0010582)1.78861325
65Mitochondrial inheritance (HP:0001427)1.77197235
66Pancreatic islet-cell hyperplasia (HP:0004510)1.76350644
67Lipid accumulation in hepatocytes (HP:0006561)1.75723240
68Long clavicles (HP:0000890)1.74753231
69Carpal bone hypoplasia (HP:0001498)1.73786051
70Methylmalonic acidemia (HP:0002912)1.73314056
71Hemivertebrae (HP:0002937)1.70477519
72Choanal atresia (HP:0000453)1.70323014
73Aplasia/Hypoplasia of the sternum (HP:0006714)1.70286741
74Cafe-au-lait spot (HP:0000957)1.70148291
75Abnormality of serum amino acid levels (HP:0003112)1.69828150
76Cerebral edema (HP:0002181)1.69103321
77Aplasia/Hypoplasia of the patella (HP:0006498)1.68310311
78Abnormality of the metopic suture (HP:0005556)1.67561509
79Gastrointestinal atresia (HP:0002589)1.64729384
80Abnormality of the hip-girdle musculature (HP:0001445)1.62473935
81Abnormality of the musculature of the pelvis (HP:0001469)1.62473935
82Tracheoesophageal fistula (HP:0002575)1.61369761
83Facial cleft (HP:0002006)1.60802132
84Abnormality of the umbilical cord (HP:0010881)1.59758026
85Dandy-Walker malformation (HP:0001305)1.59755279
86Duplicated collecting system (HP:0000081)1.59484147
87Hepatocellular necrosis (HP:0001404)1.59030123
88Duplication of thumb phalanx (HP:0009942)1.58801588
89Prominent metopic ridge (HP:0005487)1.58650640
90Ovarian neoplasm (HP:0100615)1.58530311
91Overlapping toe (HP:0001845)1.58526521
92Abnormality of the pons (HP:0007361)1.58212774
93Absent thumb (HP:0009777)1.57982964
94Abnormal umbilical cord blood vessels (HP:0011403)1.57812636
95Single umbilical artery (HP:0001195)1.57812636
96Abnormality of the fetal cardiovascular system (HP:0010948)1.57812636
97Increased serum lactate (HP:0002151)1.57303824
98Arteriovenous malformation (HP:0100026)1.56230928
99Abnormal hair whorl (HP:0010721)1.55239336
100Type I transferrin isoform profile (HP:0003642)1.55153464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.74357809
2SRPK13.80248378
3CDC73.72226784
4TTK3.25119808
5VRK22.91497917
6PBK2.78820636
7TSSK62.77714142
8PLK42.74067927
9WEE12.73590694
10MKNK12.66451268
11NEK12.64207277
12PLK32.53040177
13MKNK22.52514652
14EIF2AK12.33316420
15TAF12.28091480
16EIF2AK32.26343134
17STK162.20672013
18TRIM282.12559808
19BRSK21.93478289
20ZAK1.87609176
21VRK11.86531429
22PLK11.82062341
23NUAK11.78257448
24BCR1.60805163
25CHEK21.43895425
26BRSK11.39299007
27ATR1.37182230
28MST41.35321935
29WNK31.27904469
30AURKB1.24995490
31STK38L1.24384374
32CCNB11.22758156
33NEK21.17374034
34PASK1.13398394
35DYRK31.07290294
36EIF2AK21.03782982
37BMPR1B1.02551355
38RPS6KA41.01097883
39ERBB30.98163927
40PLK20.96338573
41MAP3K40.95521579
42CDK70.92347974
43CHEK10.92103177
44MAP2K70.91311705
45CSNK1G10.89454606
46LATS10.87808771
47CSNK1G30.87397990
48STK30.86719188
49ATM0.85818638
50NME10.82763418
51CDK80.81316676
52CLK10.79042621
53TNIK0.75737310
54CSNK1G20.74771261
55BRD40.73369319
56FLT30.72548345
57NME20.72537702
58STK40.71855323
59DYRK20.70644964
60CSNK1A1L0.68213948
61ERBB40.68175994
62AURKA0.66828012
63FGFR10.63863784
64MAP4K20.63711765
65MAP3K80.63491371
66MAP3K100.62617518
67STK100.61959878
68ALK0.61132685
69CDK60.60939051
70CDK10.57040857
71TGFBR10.55259970
72CSNK2A10.55117623
73CDK30.54277461
74PAK40.53962094
75CDK20.52046615
76CSNK2A20.49865330
77MINK10.44675612
78PNCK0.44440602
79CDK180.44078482
80CDK190.43314940
81CSNK1E0.42551249
82CDK140.42260086
83CDK40.39072977
84BCKDK0.38638618
85CDK150.37965591
86CDK11A0.36488206
87PDK20.35367728
88PRKDC0.34466291
89TLK10.33632769
90CASK0.32855326
91BRAF0.31573043
92MELK0.26674271
93SCYL20.25270336
94CDK90.24390156
95YES10.22999557
96STK240.22896009
97SIK30.22701358
98DAPK10.22026435
99EPHA40.21044678
100UHMK10.20646337

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.59405317
2Mismatch repair_Homo sapiens_hsa034304.25050018
3Proteasome_Homo sapiens_hsa030503.46836686
4Non-homologous end-joining_Homo sapiens_hsa034503.41087360
5Homologous recombination_Homo sapiens_hsa034403.03409110
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.89757315
7Spliceosome_Homo sapiens_hsa030402.84968117
8Base excision repair_Homo sapiens_hsa034102.79084340
9Cell cycle_Homo sapiens_hsa041102.76588411
10Nucleotide excision repair_Homo sapiens_hsa034202.57699523
11RNA transport_Homo sapiens_hsa030132.55906875
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52965267
13Fanconi anemia pathway_Homo sapiens_hsa034602.52477730
14Protein export_Homo sapiens_hsa030602.45505917
15RNA polymerase_Homo sapiens_hsa030202.38696500
16Ribosome_Homo sapiens_hsa030102.18950972
17One carbon pool by folate_Homo sapiens_hsa006702.12195859
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99452533
19Basal transcription factors_Homo sapiens_hsa030221.91923646
20RNA degradation_Homo sapiens_hsa030181.87078465
21Pyrimidine metabolism_Homo sapiens_hsa002401.80167343
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.65018058
23Steroid biosynthesis_Homo sapiens_hsa001001.62655485
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58304672
25mRNA surveillance pathway_Homo sapiens_hsa030151.54050349
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44634440
27Parkinsons disease_Homo sapiens_hsa050121.44477605
28Propanoate metabolism_Homo sapiens_hsa006401.40803388
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39812977
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36893028
31Biosynthesis of amino acids_Homo sapiens_hsa012301.33585250
32Pyruvate metabolism_Homo sapiens_hsa006201.32926375
33Oxidative phosphorylation_Homo sapiens_hsa001901.30432767
34p53 signaling pathway_Homo sapiens_hsa041151.22650558
35Purine metabolism_Homo sapiens_hsa002301.21614440
36Fatty acid elongation_Homo sapiens_hsa000621.20217463
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18400115
38Huntingtons disease_Homo sapiens_hsa050161.17268311
39Oocyte meiosis_Homo sapiens_hsa041141.15867073
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03874506
41Selenocompound metabolism_Homo sapiens_hsa004501.02094040
42Carbon metabolism_Homo sapiens_hsa012000.98961918
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93708609
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89049658
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87661988
46Vitamin B6 metabolism_Homo sapiens_hsa007500.84154393
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83838188
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79491210
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74291764
50Folate biosynthesis_Homo sapiens_hsa007900.71115634
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70437139
52Alzheimers disease_Homo sapiens_hsa050100.66863372
53Glutathione metabolism_Homo sapiens_hsa004800.61338372
54Basal cell carcinoma_Homo sapiens_hsa052170.60556023
55N-Glycan biosynthesis_Homo sapiens_hsa005100.57730844
56Hippo signaling pathway_Homo sapiens_hsa043900.57252340
57Epstein-Barr virus infection_Homo sapiens_hsa051690.55655105
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53170317
59TGF-beta signaling pathway_Homo sapiens_hsa043500.51015825
60Wnt signaling pathway_Homo sapiens_hsa043100.49781733
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48940286
62Metabolic pathways_Homo sapiens_hsa011000.48655709
63Hedgehog signaling pathway_Homo sapiens_hsa043400.48545872
64Alcoholism_Homo sapiens_hsa050340.47325061
65Systemic lupus erythematosus_Homo sapiens_hsa053220.46432962
66Pentose phosphate pathway_Homo sapiens_hsa000300.44648012
67MicroRNAs in cancer_Homo sapiens_hsa052060.43656931
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41911693
69Lysine degradation_Homo sapiens_hsa003100.39956340
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38747747
71Viral carcinogenesis_Homo sapiens_hsa052030.36445597
72Butanoate metabolism_Homo sapiens_hsa006500.36307978
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35759467
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33670033
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31322224
76Fatty acid metabolism_Homo sapiens_hsa012120.30626118
77Colorectal cancer_Homo sapiens_hsa052100.28809962
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28298103
79Thyroid cancer_Homo sapiens_hsa052160.27757008
80Adherens junction_Homo sapiens_hsa045200.24886602
81Peroxisome_Homo sapiens_hsa041460.20830554
82Small cell lung cancer_Homo sapiens_hsa052220.19592815
83Sulfur metabolism_Homo sapiens_hsa009200.19557074
84HTLV-I infection_Homo sapiens_hsa051660.19328925
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17554743
86Melanoma_Homo sapiens_hsa052180.17192444
87Phototransduction_Homo sapiens_hsa047440.16357518
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.13677976
89Herpes simplex infection_Homo sapiens_hsa051680.12623500
90Sulfur relay system_Homo sapiens_hsa041220.12468342
91Prostate cancer_Homo sapiens_hsa052150.12197351
92Arginine and proline metabolism_Homo sapiens_hsa003300.11075888
93Cardiac muscle contraction_Homo sapiens_hsa042600.10337415
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.09978021
95Tight junction_Homo sapiens_hsa045300.09906097
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.07225033
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.06352862
98Pathways in cancer_Homo sapiens_hsa052000.06347857
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.05520307
100Shigellosis_Homo sapiens_hsa051310.03498161

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