ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium or flagellum-dependent cell motility (GO:0001539)	9.48045261
2	motile cilium assembly (GO:0044458)	6.59824315
3	intraciliary transport (GO:0042073)	5.59412400
4	piRNA metabolic process (GO:0034587)	5.53277518
5	axoneme assembly (GO:0035082)	5.51500139
6	centriole replication (GO:0007099)	5.41119452
7	regulation of DNA methylation (GO:0044030)	5.31088866
8	regulation of meiosis I (GO:0060631)	5.06049505
9	meiotic cell cycle (GO:0051321)	5.03963559
10	regulation of cilium movement (GO:0003352)	4.88736923
11	left/right axis specification (GO:0070986)	4.78674692
12	retinal cone cell development (GO:0046549)	4.71354926
13	cilium organization (GO:0044782)	4.67114890
14	protein localization to cilium (GO:0061512)	4.61306266
15	left/right pattern formation (GO:0060972)	4.60067111
16	cilium morphogenesis (GO:0060271)	4.54723517
17	cilium assembly (GO:0042384)	4.54260303
18	regulation of female gonad development (GO:2000194)	4.50314472
19	centriole assembly (GO:0098534)	4.46296819
20	neuron fate determination (GO:0048664)	4.32565623
21	DNA methylation involved in gamete generation (GO:0043046)	4.28764775
22	ventricular system development (GO:0021591)	4.12961465
23	positive regulation of gastrulation (GO:2000543)	4.12694587
24	synapsis (GO:0007129)	3.95087914
25	multicellular organism reproduction (GO:0032504)	3.83622698
26	nonmotile primary cilium assembly (GO:0035058)	3.62785940
27	female gamete generation (GO:0007292)	3.56003963
28	cellular component assembly involved in morphogenesis (GO:0010927)	3.47296171
29	microtubule-based movement (GO:0007018)	3.40669623
30	regulation of cell maturation (GO:1903429)	3.39089139
31	smoothened signaling pathway (GO:0007224)	3.37194144
32	regulation of acrosome reaction (GO:0060046)	3.25912920
33	male meiosis (GO:0007140)	3.25422718
34	male meiosis I (GO:0007141)	3.24481681
35	determination of left/right symmetry (GO:0007368)	3.19136721
36	microtubule bundle formation (GO:0001578)	3.10181623
37	regulation of microtubule-based movement (GO:0060632)	3.07331810
38	determination of bilateral symmetry (GO:0009855)	3.06875904
39	regulation of helicase activity (GO:0051095)	3.03771496
40	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.01572870
41	specification of symmetry (GO:0009799)	3.01114306
42	CENP-A containing nucleosome assembly (GO:0034080)	2.98455059
43	oocyte development (GO:0048599)	2.97892691
44	microtubule severing (GO:0051013)	2.95127564
45	chromosome organization involved in meiosis (GO:0070192)	2.94507508
46	lateral sprouting from an epithelium (GO:0060601)	2.92012077
47	gene silencing by RNA (GO:0031047)	2.91169994
48	sperm motility (GO:0030317)	2.89302837
49	cell projection assembly (GO:0030031)	2.89227308
50	chromatin remodeling at centromere (GO:0031055)	2.84959623
51	genitalia morphogenesis (GO:0035112)	2.82276225
52	photoreceptor cell maintenance (GO:0045494)	2.80654939
53	negative regulation of reproductive process (GO:2000242)	2.80304880
54	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.79409484
55	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.79409484
56	regulation of histone H3-K9 methylation (GO:0051570)	2.75494222
57	primitive streak formation (GO:0090009)	2.73872585
58	sperm capacitation (GO:0048240)	2.73535939
59	synaptonemal complex assembly (GO:0007130)	2.72744284
60	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.68675058
61	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.68675058
62	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.68675058
63	meiotic cell cycle process (GO:1903046)	2.68479333
64	spermatid development (GO:0007286)	2.67277888
65	relaxation of smooth muscle (GO:0044557)	2.67091360
66	intra-S DNA damage checkpoint (GO:0031573)	2.65916576
67	spermatid nucleus differentiation (GO:0007289)	2.64632689
68	vitamin transmembrane transport (GO:0035461)	2.63049054
69	mismatch repair (GO:0006298)	2.62961970
70	reciprocal meiotic recombination (GO:0007131)	2.62647396
71	reciprocal DNA recombination (GO:0035825)	2.62647396
72	meiosis I (GO:0007127)	2.62297438
73	resolution of meiotic recombination intermediates (GO:0000712)	2.61548520
74	fertilization (GO:0009566)	2.61445390
75	positive regulation of histone H3-K4 methylation (GO:0051571)	2.59453174
76	microtubule depolymerization (GO:0007019)	2.59172498
77	synaptonemal complex organization (GO:0070193)	2.54338520
78	regulation of steroid hormone secretion (GO:2000831)	2.54064504
79	negative regulation of DNA recombination (GO:0045910)	2.53769077
80	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.52433660
81	establishment of chromosome localization (GO:0051303)	2.50259833
82	lateral ventricle development (GO:0021670)	2.48723158
83	somite rostral/caudal axis specification (GO:0032525)	2.46521141
84	presynaptic membrane assembly (GO:0097105)	2.46071050
85	microtubule polymerization or depolymerization (GO:0031109)	2.44804472
86	paraxial mesoderm development (GO:0048339)	2.41721786
87	single fertilization (GO:0007338)	2.41582681
88	photoreceptor cell development (GO:0042461)	2.41179081
89	histone exchange (GO:0043486)	2.40007077
90	glycine transport (GO:0015816)	2.38338253
91	meiotic nuclear division (GO:0007126)	2.38149409
92	organelle assembly (GO:0070925)	2.37651993
93	protein localization to kinetochore (GO:0034501)	2.37371159
94	establishment of tissue polarity (GO:0007164)	2.37087986
95	establishment of planar polarity (GO:0001736)	2.37087986
96	nucleoside diphosphate phosphorylation (GO:0006165)	2.37076245
97	axonemal dynein complex assembly (GO:0070286)	10.5905080
98	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	10.4161657
99	cilium movement (GO:0003341)	10.2556152
100	epithelial cilium movement (GO:0003351)	10.0070972

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.33203037
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.76361550
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.60805546
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.26253099
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.99644624
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.57709549
7	VDR_22108803_ChIP-Seq_LS180_Human	2.29932587
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.27866674
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.17089637
10	EWS_26573619_Chip-Seq_HEK293_Human	2.10769628
11	FUS_26573619_Chip-Seq_HEK293_Human	2.10354613
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.07632513
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.06977335
14	P300_19829295_ChIP-Seq_ESCs_Human	2.03052864
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00553074
16	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.93046983
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.92850200
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.88252117
19	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.84652640
20	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.77108603
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72309256
22	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.67297241
23	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.63441416
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.63267375
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61200483
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.58940885
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.58328465
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.55992935
29	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.55655869
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.54881849
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.49489864
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49304091
33	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.48811189
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48208418
35	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.47901727
36	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.45002037
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.44029243
38	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43979901
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42896465
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42791176
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.42526663
42	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.42467479
43	AR_25329375_ChIP-Seq_VCAP_Human	1.39772397
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39659546
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.39659546
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.38789115
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38653181
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.38653181
49	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37950583
50	STAT3_23295773_ChIP-Seq_U87_Human	1.36889276
51	TCF4_23295773_ChIP-Seq_U87_Human	1.35690825
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34144125
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34117678
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.33141086
55	TP53_16413492_ChIP-PET_HCT116_Human	1.30612760
56	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.30534208
57	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.30534208
58	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.30534208
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.30331163
60	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.29838509
61	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.29783330
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.29440777
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28855761
64	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.27884204
65	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.26358142
66	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.25341273
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22364459
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.18985718
69	MYC_18940864_ChIP-ChIP_HL60_Human	1.18126198
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17086503
71	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.15802176
72	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14655704
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.13792676
74	IGF1R_20145208_ChIP-Seq_DFB_Human	1.12152919
75	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09016749
76	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08879527
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08852628
78	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07381082
79	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07381082
80	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07022520
81	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06464603
82	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06312147
83	ELK1_19687146_ChIP-ChIP_HELA_Human	1.05759260
84	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05718045
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05718045
86	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02577477
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02483192
88	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02460792
89	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02310546
90	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.02305036
91	TP53_22573176_ChIP-Seq_HFKS_Human	1.02162427
92	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.00272210
93	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.98828846
94	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.98558670
95	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97444398
96	TP53_18474530_ChIP-ChIP_U2OS_Human	0.95358770
97	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.94549048
98	DROSHA_22980978_ChIP-Seq_HELA_Human	0.93033562
99	CBP_21632823_ChIP-Seq_H3396_Human	0.92903544
100	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.92273462

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	4.27877317
2	MP0008789_abnormal_olfactory_epithelium	4.16122972
3	MP0008877_abnormal_DNA_methylation	3.98694895
4	MP0006292_abnormal_olfactory_placode	3.74908065
5	MP0002653_abnormal_ependyma_morphology	3.66854762
6	MP0005394_taste/olfaction_phenotype	3.43704269
7	MP0005499_abnormal_olfactory_system	3.43704269
8	MP0001984_abnormal_olfaction	3.29056826
9	MP0010030_abnormal_orbit_morphology	3.17590552
10	MP0003136_yellow_coat_color	2.98794548
11	MP0000566_synostosis	2.38111664
12	MP0008875_abnormal_xenobiotic_pharmacok	1.95737229
13	MP0003890_abnormal_embryonic-extraembry	1.95205655
14	MP0001293_anophthalmia	1.87384298
15	MP0005395_other_phenotype	1.77530155
16	MP0009379_abnormal_foot_pigmentation	1.72159803
17	MP0002233_abnormal_nose_morphology	1.67215552
18	MP0001929_abnormal_gametogenesis	1.67213087
19	MP0004133_heterotaxia	1.65400470
20	MP0002234_abnormal_pharynx_morphology	1.65233453
21	MP0002638_abnormal_pupillary_reflex	1.64004735
22	MP0006276_abnormal_autonomic_nervous	1.63210272
23	MP0005551_abnormal_eye_electrophysiolog	1.62542615
24	MP0000049_abnormal_middle_ear	1.61381737
25	MP0000631_abnormal_neuroendocrine_gland	1.61209447
26	MP0006072_abnormal_retinal_apoptosis	1.57228851
27	MP0002210_abnormal_sex_determination	1.56820392
28	MP0003122_maternal_imprinting	1.55804749
29	MP0002928_abnormal_bile_duct	1.55397660
30	MP0002160_abnormal_reproductive_system	1.54557579
31	MP0002139_abnormal_hepatobiliary_system	1.46712710
32	MP0004142_abnormal_muscle_tone	1.45113462
33	MP0000026_abnormal_inner_ear	1.39651234
34	MP0003195_calcinosis	1.39420954
35	MP0003878_abnormal_ear_physiology	1.37711772
36	MP0005377_hearing/vestibular/ear_phenot	1.37711772
37	MP0003121_genomic_imprinting	1.37311774
38	MP0003880_abnormal_central_pattern	1.37066924
39	MP0002102_abnormal_ear_morphology	1.35269812
40	MP0005171_absent_coat_pigmentation	1.34768871
41	MP0000383_abnormal_hair_follicle	1.30266282
42	MP0003698_abnormal_male_reproductive	1.29365360
43	MP0000653_abnormal_sex_gland	1.28484802
44	MP0005646_abnormal_pituitary_gland	1.23926280
45	MP0005410_abnormal_fertilization	1.19354759
46	MP0001324_abnormal_eye_pigmentation	1.17978597
47	MP0005253_abnormal_eye_physiology	1.17640152
48	MP0001485_abnormal_pinna_reflex	1.15278790
49	MP0003119_abnormal_digestive_system	1.15134623
50	MP0002272_abnormal_nervous_system	1.14556947
51	MP0002161_abnormal_fertility/fecundity	1.12811130
52	MP0005360_urolithiasis	1.11830411
53	MP0008058_abnormal_DNA_repair	1.09907708
54	MP0001145_abnormal_male_reproductive	1.09499730
55	MP0002938_white_spotting	1.09054760
56	MP0004043_abnormal_pH_regulation	1.08649848
57	MP0000762_abnormal_tongue_morphology	1.08588641
58	MP0003937_abnormal_limbs/digits/tail_de	1.07722737
59	MP0000372_irregular_coat_pigmentation	1.06997170
60	MP0010678_abnormal_skin_adnexa	1.05960473
61	MP0003699_abnormal_female_reproductive	1.05558912
62	MP0001529_abnormal_vocalization	1.04632542
63	MP0001963_abnormal_hearing_physiology	1.04146647
64	MP0003879_abnormal_hair_cell	1.03608579
65	MP0002282_abnormal_trachea_morphology	1.03490358
66	MP0000778_abnormal_nervous_system	1.02783526
67	MP0002751_abnormal_autonomic_nervous	1.00845939
68	MP0001286_abnormal_eye_development	0.99794531
69	MP0000427_abnormal_hair_cycle	0.98134285
70	MP0004019_abnormal_vitamin_homeostasis	0.97860708
71	MP0002734_abnormal_mechanical_nocicepti	0.94806662
72	MP0002277_abnormal_respiratory_mucosa	0.92080231
73	MP0005389_reproductive_system_phenotype	0.91211816
74	MP0005195_abnormal_posterior_eye	0.89639765
75	MP0003938_abnormal_ear_development	0.89624749
76	MP0003755_abnormal_palate_morphology	0.87380023
77	MP0005248_abnormal_Harderian_gland	0.86115733
78	MP0005503_abnormal_tendon_morphology	0.83915940
79	MP0001486_abnormal_startle_reflex	0.82264166
80	MP0005391_vision/eye_phenotype	0.81582072
81	MP0009745_abnormal_behavioral_response	0.81496075
82	MP0002752_abnormal_somatic_nervous	0.81415969
83	MP0001502_abnormal_circadian_rhythm	0.80249027
84	MP0002132_abnormal_respiratory_system	0.78675441
85	MP0003950_abnormal_plasma_membrane	0.75738880
86	MP0001119_abnormal_female_reproductive	0.75109607
87	MP0009780_abnormal_chondrocyte_physiolo	0.74461404
88	MP0003861_abnormal_nervous_system	0.74411394
89	MP0002557_abnormal_social/conspecific_i	0.74263646
90	MP0003252_abnormal_bile_duct	0.73270045
91	MP0009697_abnormal_copulation	0.72955379
92	MP0005085_abnormal_gallbladder_physiolo	0.72769589
93	MP0003787_abnormal_imprinting	0.71484739
94	MP0002572_abnormal_emotion/affect_behav	0.70723107
95	MP0003186_abnormal_redox_activity	0.70156834
96	MP0003011_delayed_dark_adaptation	0.68696623
97	MP0008995_early_reproductive_senescence	0.68666163
98	MP0008932_abnormal_embryonic_tissue	0.68583667
99	MP0002697_abnormal_eye_size	0.66141228
100	MP0001346_abnormal_lacrimal_gland	0.64408848

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal ciliary motility (HP:0012262)	8.12556607
2	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	8.07566548
3	Abnormal respiratory motile cilium physiology (HP:0012261)	7.75739103
4	Abnormal respiratory epithelium morphology (HP:0012253)	7.33124360
5	Abnormal respiratory motile cilium morphology (HP:0005938)	7.33124360
6	Absent/shortened dynein arms (HP:0200106)	7.10451447
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.10451447
8	Rhinitis (HP:0012384)	6.99667695
9	Chronic bronchitis (HP:0004469)	4.57318172
10	Bronchiectasis (HP:0002110)	4.48590337
11	Supernumerary spleens (HP:0009799)	4.40387468
12	Pancreatic fibrosis (HP:0100732)	4.38970669
13	True hermaphroditism (HP:0010459)	4.17472596
14	Pancreatic cysts (HP:0001737)	4.04677431
15	Abnormality of midbrain morphology (HP:0002418)	3.80929429
16	Molar tooth sign on MRI (HP:0002419)	3.80929429
17	Medial flaring of the eyebrow (HP:0010747)	3.69144970
18	Nephronophthisis (HP:0000090)	3.58474111
19	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.32217945
20	Infertility (HP:0000789)	3.27038013
21	Occipital encephalocele (HP:0002085)	3.25008547
22	Gait imbalance (HP:0002141)	3.23724415
23	Median cleft lip (HP:0000161)	3.21321065
24	Congenital primary aphakia (HP:0007707)	3.21199491
25	Cystic liver disease (HP:0006706)	3.14654581
26	Nasal polyposis (HP:0100582)	3.13645523
27	Septo-optic dysplasia (HP:0100842)	3.05816399
28	Oligodactyly (hands) (HP:0001180)	2.93475821
29	Abnormality of the renal medulla (HP:0100957)	2.84644025
30	Chronic sinusitis (HP:0011109)	2.83470548
31	Nephrogenic diabetes insipidus (HP:0009806)	2.81738240
32	Postaxial foot polydactyly (HP:0001830)	2.77972483
33	Anencephaly (HP:0002323)	2.77228555
34	Chronic hepatic failure (HP:0100626)	2.74135711
35	Abdominal situs inversus (HP:0003363)	2.60906152
36	Abnormality of abdominal situs (HP:0011620)	2.60906152
37	Genital tract atresia (HP:0001827)	2.60049698
38	Postaxial hand polydactyly (HP:0001162)	2.55910760
39	Tubular atrophy (HP:0000092)	2.53953353
40	Bile duct proliferation (HP:0001408)	2.52123615
41	Abnormal biliary tract physiology (HP:0012439)	2.52123615
42	Abnormality of the labia minora (HP:0012880)	2.48205890
43	Short tibia (HP:0005736)	2.47472521
44	Congenital hepatic fibrosis (HP:0002612)	2.46961745
45	Vaginal atresia (HP:0000148)	2.41917221
46	Abnormality of the nasal mucosa (HP:0000433)	2.38396433
47	Absent septum pellucidum (HP:0001331)	2.38176263
48	Preaxial hand polydactyly (HP:0001177)	2.31780211
49	Recurrent sinusitis (HP:0011108)	2.29848815
50	Male infertility (HP:0003251)	2.29640331
51	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.29174248
52	Sclerocornea (HP:0000647)	2.27693981
53	Tubulointerstitial nephritis (HP:0001970)	2.25071167
54	Poor coordination (HP:0002370)	2.21589777
55	Bronchitis (HP:0012387)	2.19176818
56	Male pseudohermaphroditism (HP:0000037)	2.07582877
57	Oligodactyly (HP:0012165)	2.05154141
58	Oculomotor apraxia (HP:0000657)	1.95620172
59	Abnormality of the septum pellucidum (HP:0007375)	1.94098463
60	Maternal diabetes (HP:0009800)	1.90926388
61	Abnormality of the renal cortex (HP:0011035)	1.84444310
62	Optic nerve hypoplasia (HP:0000609)	1.79858142
63	Cholecystitis (HP:0001082)	1.77621341
64	Abnormal gallbladder physiology (HP:0012438)	1.77621341
65	Bifid tongue (HP:0010297)	1.77112489
66	Osteomalacia (HP:0002749)	1.75350936
67	Facial hemangioma (HP:0000329)	1.74901278
68	Aplasia/Hypoplasia of the lens (HP:0008063)	1.72089422
69	Holoprosencephaly (HP:0001360)	1.68870926
70	Azoospermia (HP:0000027)	1.68029033
71	Aganglionic megacolon (HP:0002251)	1.65801197
72	Hyperactive renin-angiotensin system (HP:0000841)	1.65693410
73	Multicystic kidney dysplasia (HP:0000003)	1.65351927
74	Anophthalmia (HP:0000528)	1.65069270
75	Recurrent otitis media (HP:0000403)	1.63386738
76	Broad foot (HP:0001769)	1.62662147
77	Tubulointerstitial abnormality (HP:0001969)	1.62063417
78	Abnormality of the fovea (HP:0000493)	1.59105770
79	Furrowed tongue (HP:0000221)	1.59073597
80	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.56951155
81	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.55404248
82	Hypoplasia of the fovea (HP:0007750)	1.55404248
83	Narrow forehead (HP:0000341)	1.55330682
84	Hyperglycinemia (HP:0002154)	1.51021291
85	Agnosia (HP:0010524)	1.50643518
86	Abnormal drinking behavior (HP:0030082)	1.50562920
87	Polydipsia (HP:0001959)	1.50562920
88	Decreased testicular size (HP:0008734)	1.49563574
89	Retinitis pigmentosa (HP:0000510)	1.47814070
90	Reticulocytopenia (HP:0001896)	1.47041603
91	Stenosis of the external auditory canal (HP:0000402)	1.46736170
92	Prominent nasal bridge (HP:0000426)	1.45591210
93	Neoplasm of the oral cavity (HP:0100649)	1.43874628
94	Decreased central vision (HP:0007663)	1.43098831
95	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.42320846
96	Specific learning disability (HP:0001328)	1.40155602
97	Rhabdomyosarcoma (HP:0002859)	1.40126050
98	Type II lissencephaly (HP:0007260)	1.39638073
99	Dandy-Walker malformation (HP:0001305)	1.39285669
100	Meckel diverticulum (HP:0002245)	1.38327603

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	5.33940837
2	TNIK	3.31886174
3	MST4	2.79676897
4	ARAF	2.50613385
5	MAP4K2	2.50572286
6	WNK3	2.49406081
7	MAP3K9	2.30097956
8	NEK6	2.12274449
9	TTK	2.04976516
10	PNCK	2.02666623
11	STK24	1.96721313
12	VRK1	1.88238176
13	ZAK	1.76371822
14	MAP3K4	1.75746612
15	MET	1.73248138
16	TAOK3	1.69743144
17	NTRK2	1.56129740
18	BCR	1.53134856
19	BMPR1B	1.49434210
20	CDK9	1.47320901
21	TLK1	1.39438329
22	EPHA4	1.39038181
23	EIF2AK3	1.34446179
24	AURKA	1.33596947
25	STK39	1.30560003
26	TRIM28	1.28079402
27	CDC7	1.26535431
28	MAP2K7	1.24286428
29	EPHB2	1.23796059
30	NUAK1	1.23137499
31	PLK3	1.21042139
32	PRKCI	1.18547108
33	BRAF	1.18455154
34	PLK1	1.15725136
35	MAP3K13	1.12061243
36	MUSK	1.09797732
37	TIE1	1.07475130
38	MAPK13	1.06882300
39	CDK19	1.04625399
40	ADRBK2	1.01029968
41	INSRR	1.00130263
42	TGFBR1	0.95271800
43	RAF1	0.94472335
44	PINK1	0.94077429
45	STK16	0.93438365
46	WEE1	0.90122378
47	BRSK2	0.89181375
48	MARK1	0.88774422
49	VRK2	0.88626475
50	MOS	0.88200470
51	BCKDK	0.87724432
52	PASK	0.87694322
53	PTK2B	0.87487736
54	STK3	0.86610387
55	NEK9	0.86114081
56	OXSR1	0.85197763
57	TSSK6	0.85128321
58	CASK	0.84222204
59	GRK1	0.83460624
60	DYRK2	0.83089110
61	NME1	0.81513935
62	NEK2	0.78728737
63	KSR1	0.77210281
64	ERBB3	0.77135163
65	CSNK1G1	0.74805553
66	STK38L	0.72674451
67	NLK	0.72482776
68	NTRK3	0.71584989
69	CAMK2A	0.64910701
70	DYRK3	0.63620685
71	CSNK1G2	0.63610542
72	KSR2	0.61240075
73	PRKG1	0.60508273
74	PLK2	0.59318963
75	SRPK1	0.58993839
76	WNK4	0.58229025
77	MKNK1	0.57702465
78	CDK8	0.57247758
79	PRKCG	0.56030416
80	MKNK2	0.54993342
81	CSNK1G3	0.54239063
82	PKN1	0.53727166
83	PRKCE	0.53116668
84	PAK4	0.52698458
85	PRKACA	0.51334499
86	MAP3K12	0.50080015
87	ACVR1B	0.45458722
88	CSNK1D	0.43079358
89	CHEK2	0.42938935
90	FRK	0.41732107
91	CSNK1A1L	0.40943291
92	DYRK1A	0.39738788
93	FGFR1	0.39608549
94	AURKB	0.39395704
95	ATM	0.37654845
96	EPHA2	0.37119586
97	BRSK1	0.35081897
98	ADRBK1	0.33382064
99	ATR	0.33184830
100	CDK3	0.31999319

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mismatch repair_Homo sapiens_hsa03430	3.04581439
2	Basal transcription factors_Homo sapiens_hsa03022	3.03288279
3	Huntingtons disease_Homo sapiens_hsa05016	2.87892718
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.64452126
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.50385051
6	Caffeine metabolism_Homo sapiens_hsa00232	2.48726480
7	Ribosome_Homo sapiens_hsa03010	2.36202837
8	Parkinsons disease_Homo sapiens_hsa05012	2.25875193
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.15316898
10	Protein export_Homo sapiens_hsa03060	2.10049711
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.08939927
12	Phototransduction_Homo sapiens_hsa04744	2.02134587
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.95212346
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.93310698
15	Nicotine addiction_Homo sapiens_hsa05033	1.90844367
16	Homologous recombination_Homo sapiens_hsa03440	1.87550174
17	RNA degradation_Homo sapiens_hsa03018	1.87318859
18	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.82598584
19	Propanoate metabolism_Homo sapiens_hsa00640	1.76968120
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.65319215
21	Chemical carcinogenesis_Homo sapiens_hsa05204	1.64330304
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.60483772
23	Cell cycle_Homo sapiens_hsa04110	1.57707331
24	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.55348883
25	Alzheimers disease_Homo sapiens_hsa05010	1.50931816
26	Oocyte meiosis_Homo sapiens_hsa04114	1.41692420
27	Folate biosynthesis_Homo sapiens_hsa00790	1.39367285
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.38124396
29	RNA polymerase_Homo sapiens_hsa03020	1.37361529
30	Basal cell carcinoma_Homo sapiens_hsa05217	1.36212394
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.31120001
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.25338980
33	Olfactory transduction_Homo sapiens_hsa04740	1.25333370
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.22771355
35	Glutathione metabolism_Homo sapiens_hsa00480	1.20578567
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.18816864
37	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.14478051
38	Circadian rhythm_Homo sapiens_hsa04710	1.12843141
39	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.12494205
40	Histidine metabolism_Homo sapiens_hsa00340	1.12074266
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.11679570
42	Tyrosine metabolism_Homo sapiens_hsa00350	1.05426245
43	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.04331396
44	Base excision repair_Homo sapiens_hsa03410	1.01927831
45	Phenylalanine metabolism_Homo sapiens_hsa00360	1.01123254
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00152192
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.99164065
48	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.97727645
49	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.97648019
50	Taste transduction_Homo sapiens_hsa04742	0.95761011
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.95206537
52	RNA transport_Homo sapiens_hsa03013	0.95061718
53	Butanoate metabolism_Homo sapiens_hsa00650	0.93368063
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.92797433
55	Fatty acid elongation_Homo sapiens_hsa00062	0.91111867
56	Retinol metabolism_Homo sapiens_hsa00830	0.90927242
57	Peroxisome_Homo sapiens_hsa04146	0.89321910
58	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.88731453
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88181048
60	Pyruvate metabolism_Homo sapiens_hsa00620	0.85992004
61	GABAergic synapse_Homo sapiens_hsa04727	0.84806889
62	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.82687813
63	Purine metabolism_Homo sapiens_hsa00230	0.81045121
64	Hippo signaling pathway_Homo sapiens_hsa04390	0.78906026
65	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.76920671
66	ABC transporters_Homo sapiens_hsa02010	0.72989719
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71629411
68	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.69407167
69	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.69249614
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68124596
71	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.68038526
72	Metabolic pathways_Homo sapiens_hsa01100	0.66969713
73	DNA replication_Homo sapiens_hsa03030	0.64662818
74	Arginine and proline metabolism_Homo sapiens_hsa00330	0.63449712
75	Regulation of autophagy_Homo sapiens_hsa04140	0.63107453
76	Morphine addiction_Homo sapiens_hsa05032	0.62090805
77	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.60506164
78	Proteasome_Homo sapiens_hsa03050	0.57404624
79	p53 signaling pathway_Homo sapiens_hsa04115	0.57302603
80	Serotonergic synapse_Homo sapiens_hsa04726	0.55593916
81	Wnt signaling pathway_Homo sapiens_hsa04310	0.52719651
82	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.51921489
83	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51721864
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.49345966
85	Mineral absorption_Homo sapiens_hsa04978	0.48820519
86	Spliceosome_Homo sapiens_hsa03040	0.46923905
87	Bile secretion_Homo sapiens_hsa04976	0.46884773
88	Tryptophan metabolism_Homo sapiens_hsa00380	0.46149208
89	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.44899336
90	Ether lipid metabolism_Homo sapiens_hsa00565	0.44505708
91	Cocaine addiction_Homo sapiens_hsa05030	0.43716097
92	Axon guidance_Homo sapiens_hsa04360	0.42283127
93	Non-homologous end-joining_Homo sapiens_hsa03450	0.40820644
94	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.40307435
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.40010144
96	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.39081839
97	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.36959830
98	Melanogenesis_Homo sapiens_hsa04916	0.35991157
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.35715471
100	Gap junction_Homo sapiens_hsa04540	0.34612933

C4ORF47

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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