C4ORF51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)8.59080023
2sperm motility (GO:0030317)6.44373507
3DNA methylation involved in gamete generation (GO:0043046)6.23612437
4fusion of sperm to egg plasma membrane (GO:0007342)6.08619277
5centriole replication (GO:0007099)6.05751211
6spermatid development (GO:0007286)5.68530891
7acrosome reaction (GO:0007340)5.67645735
8retinal cone cell development (GO:0046549)5.60348114
9microtubule depolymerization (GO:0007019)5.55955471
10chromosome condensation (GO:0030261)5.36926968
11multicellular organism reproduction (GO:0032504)5.32408613
12single strand break repair (GO:0000012)5.27664414
13male meiosis I (GO:0007141)5.19753214
14microtubule polymerization or depolymerization (GO:0031109)5.09985164
15DNA packaging (GO:0006323)4.96102122
16sperm-egg recognition (GO:0035036)4.75987991
17regulation of centriole replication (GO:0046599)4.74357862
18negative regulation of meiosis (GO:0045835)4.69752176
19centriole assembly (GO:0098534)4.62520291
20binding of sperm to zona pellucida (GO:0007339)4.56488081
21oogenesis (GO:0048477)4.53665173
22male gamete generation (GO:0048232)4.53033658
23spermatogenesis (GO:0007283)4.52450890
24meiotic cell cycle (GO:0051321)4.51483935
25plasma membrane fusion (GO:0045026)4.46190006
26female gamete generation (GO:0007292)4.44077412
27polyamine biosynthetic process (GO:0006596)4.43159807
28synapsis (GO:0007129)4.41701358
29protein polyglutamylation (GO:0018095)4.38564301
30regulation of DNA methylation (GO:0044030)4.37025159
31rRNA methylation (GO:0031167)4.33888892
32gamete generation (GO:0007276)4.29035637
33meiosis I (GO:0007127)4.19899677
34reproduction (GO:0000003)4.12748597
35germ cell development (GO:0007281)4.11893957
36meiotic nuclear division (GO:0007126)4.10324002
37male meiosis (GO:0007140)4.08636824
38fertilization (GO:0009566)4.08607036
39single fertilization (GO:0007338)4.04229988
40sperm capacitation (GO:0048240)4.01774188
41sphingosine metabolic process (GO:0006670)3.89302735
42sister chromatid cohesion (GO:0007062)3.87221590
43microtubule severing (GO:0051013)3.83516896
44negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.82685632
45somatic hypermutation of immunoglobulin genes (GO:0016446)3.82443070
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.82443070
47seminiferous tubule development (GO:0072520)3.77223482
48cell-cell recognition (GO:0009988)3.76563870
49rRNA modification (GO:0000154)3.74667704
50meiotic cell cycle process (GO:1903046)3.71554799
51epithelial cilium movement (GO:0003351)3.71022498
52chromosome organization involved in meiosis (GO:0070192)3.70200843
53positive regulation of meiosis (GO:0045836)3.69607130
54mitotic metaphase plate congression (GO:0007080)3.65968617
55notochord development (GO:0030903)3.63140741
56gene silencing by RNA (GO:0031047)3.62284180
57cellular biogenic amine biosynthetic process (GO:0042401)3.59672361
58positive regulation of meiotic cell cycle (GO:0051446)3.52964050
59diol metabolic process (GO:0034311)3.48960149
60glomerular visceral epithelial cell development (GO:0072015)3.47153959
61protein targeting to Golgi (GO:0000042)3.45238782
62nuclear pore complex assembly (GO:0051292)3.43299053
63synaptonemal complex assembly (GO:0007130)3.42952199
64histone exchange (GO:0043486)3.42765598
65regulation of meiosis (GO:0040020)3.42488973
66amine biosynthetic process (GO:0009309)3.40191397
67cellular process involved in reproduction in multicellular organism (GO:0022412)3.37764000
68establishment of protein localization to Golgi (GO:0072600)3.37053818
69multicellular organismal reproductive process (GO:0048609)3.35016706
70spermatid nucleus differentiation (GO:0007289)3.34970394
71regulation of protein glycosylation (GO:0060049)3.25771123
72regulation of acrosome reaction (GO:0060046)3.25647092
73DNA alkylation (GO:0006305)3.24688115
74DNA methylation (GO:0006306)3.24688115
75regulation of retinoic acid receptor signaling pathway (GO:0048385)3.23518085
76nuclear pore organization (GO:0006999)3.23365023
77sphingoid metabolic process (GO:0046519)3.20508631
78synaptonemal complex organization (GO:0070193)3.19615450
79axonemal dynein complex assembly (GO:0070286)3.17445024
80negative regulation of DNA-dependent DNA replication (GO:2000104)3.15571339
81retrograde transport, vesicle recycling within Golgi (GO:0000301)3.15044348
82regulation of centrosome cycle (GO:0046605)3.15038332
83phosphatidylethanolamine biosynthetic process (GO:0006646)3.14378835
84DNA replication checkpoint (GO:0000076)3.14135586
85glomerular epithelial cell development (GO:0072310)3.12876306
86paraxial mesoderm development (GO:0048339)3.11862845
87positive regulation of chromosome segregation (GO:0051984)3.11799884
88calcium ion-dependent exocytosis (GO:0017156)3.11154362
89pore complex assembly (GO:0046931)3.06962109
90N-terminal protein amino acid acetylation (GO:0006474)3.06416580
91somite rostral/caudal axis specification (GO:0032525)3.04823969
92cilium movement (GO:0003341)3.02700803
93phosphatidylethanolamine metabolic process (GO:0046337)3.00858171
94mitotic chromosome condensation (GO:0007076)2.95947737
95regulation of histone H3-K9 methylation (GO:0051570)2.93554801
96metaphase plate congression (GO:0051310)2.92839303
97meiotic chromosome segregation (GO:0045132)2.89326599
98cilium or flagellum-dependent cell motility (GO:0001539)2.88813185
99regulation of meiotic cell cycle (GO:0051445)2.88524627
100regulation of meiosis I (GO:0060631)10.1736620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.88974444
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.41630668
3POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.81282175
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81282175
5E2F7_22180533_ChIP-Seq_HELA_Human2.79084654
6VDR_22108803_ChIP-Seq_LS180_Human2.76829850
7ZNF274_21170338_ChIP-Seq_K562_Hela2.65497989
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51277908
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51262147
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.40148289
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26795895
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.13016805
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08729853
14NOTCH1_21737748_ChIP-Seq_TLL_Human1.98443726
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.92026084
16P300_19829295_ChIP-Seq_ESCs_Human1.91247481
17UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.90131349
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87852692
19IGF1R_20145208_ChIP-Seq_DFB_Human1.82520102
20IRF1_19129219_ChIP-ChIP_H3396_Human1.81028667
21CBP_20019798_ChIP-Seq_JUKART_Human1.76717833
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.76717833
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.76268950
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72261293
25GBX2_23144817_ChIP-Seq_PC3_Human1.68796962
26FUS_26573619_Chip-Seq_HEK293_Human1.68489992
27SMAD4_21741376_ChIP-Seq_EPCs_Human1.62127623
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60809376
29STAT3_23295773_ChIP-Seq_U87_Human1.57534078
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57163997
31AR_21572438_ChIP-Seq_LNCaP_Human1.51801665
32TAF15_26573619_Chip-Seq_HEK293_Human1.51769855
33TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51633867
34HOXB7_26014856_ChIP-Seq_BT474_Human1.50031671
35NANOG_20526341_ChIP-Seq_ESCs_Human1.49646683
36NANOG_19829295_ChIP-Seq_ESCs_Human1.49213003
37SOX2_19829295_ChIP-Seq_ESCs_Human1.49213003
38AUTS2_25519132_ChIP-Seq_293T-REX_Human1.46869304
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45348955
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45348955
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45348955
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44714205
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44077511
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43955325
45GATA3_21878914_ChIP-Seq_MCF-7_Human1.42219010
46AR_25329375_ChIP-Seq_VCAP_Human1.42164855
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40807529
48VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.37892380
49TCF4_23295773_ChIP-Seq_U87_Human1.35699792
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34054555
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.33397172
52ER_23166858_ChIP-Seq_MCF-7_Human1.32477329
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.31582517
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29865913
55SMAD4_21799915_ChIP-Seq_A2780_Human1.29063010
56MYC_19829295_ChIP-Seq_ESCs_Human1.28711376
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.27082774
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.24133808
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24133808
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24003930
61SMAD3_21741376_ChIP-Seq_ESCs_Human1.21488611
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21194106
63CEBPB_22108803_ChIP-Seq_LS180_Human1.17997251
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.17333966
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16883809
66RUNX2_22187159_ChIP-Seq_PCA_Human1.15370363
67ERA_21632823_ChIP-Seq_H3396_Human1.14952064
68CDX2_22108803_ChIP-Seq_LS180_Human1.14835890
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12514627
70OCT4_20526341_ChIP-Seq_ESCs_Human1.12239577
71FOXH1_21741376_ChIP-Seq_EPCs_Human1.11958924
72E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11225495
73TP53_22573176_ChIP-Seq_HFKS_Human1.10944074
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10384198
75TCF4_22108803_ChIP-Seq_LS180_Human1.10180064
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09538383
77PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09225993
78NCOR_22424771_ChIP-Seq_293T_Human1.08954631
79ERG_20517297_ChIP-Seq_VCAP_Human1.08553954
80WDR5_24793694_ChIP-Seq_LNCAP_Human1.07672396
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07479670
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07469675
83RAC3_21632823_ChIP-Seq_H3396_Human1.06567168
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06252423
85HTT_18923047_ChIP-ChIP_STHdh_Human1.04874233
86* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03876048
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03197541
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02342450
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.01078326
90SMAD4_21741376_ChIP-Seq_HESCs_Human1.00598037
91TAF2_19829295_ChIP-Seq_ESCs_Human0.99725479
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99382230
93E2F1_17053090_ChIP-ChIP_MCF-7_Human0.98232789
94EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97119941
95AR_20517297_ChIP-Seq_VCAP_Human0.94269974
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93358506
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92632586
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92372109
99OCT1_27270436_Chip-Seq_PROSTATE_Human0.92202521
100FOXM1_23109430_ChIP-Seq_U2OS_Human0.90837957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.37006457
2MP0003718_maternal_effect5.28317758
3MP0003136_yellow_coat_color4.02839398
4MP0005670_abnormal_white_adipose3.42180134
5MP0003646_muscle_fatigue3.28108483
6MP0001929_abnormal_gametogenesis3.01732354
7MP0003698_abnormal_male_reproductive2.80570195
8MP0008877_abnormal_DNA_methylation2.77158003
9MP0003890_abnormal_embryonic-extraembry2.64876563
10MP0002138_abnormal_hepatobiliary_system2.58963251
11MP0002837_dystrophic_cardiac_calcinosis2.57694276
12MP0003693_abnormal_embryo_hatching2.53470889
13MP0005377_hearing/vestibular/ear_phenot2.51733835
14MP0003878_abnormal_ear_physiology2.51733835
15MP0004957_abnormal_blastocyst_morpholog2.47780978
16MP0005085_abnormal_gallbladder_physiolo2.47690718
17MP0002210_abnormal_sex_determination2.24594013
18MP0005395_other_phenotype2.23947335
19MP0003879_abnormal_hair_cell2.14946397
20MP0002653_abnormal_ependyma_morphology2.05241432
21MP0003950_abnormal_plasma_membrane1.99648900
22MP0005551_abnormal_eye_electrophysiolog1.95431198
23MP0003077_abnormal_cell_cycle1.88688449
24MP0010094_abnormal_chromosome_stability1.85820311
25MP0008058_abnormal_DNA_repair1.85797567
26MP0005171_absent_coat_pigmentation1.78396358
27MP0002161_abnormal_fertility/fecundity1.77092878
28MP0001145_abnormal_male_reproductive1.74718175
29MP0000653_abnormal_sex_gland1.66153830
30MP0002638_abnormal_pupillary_reflex1.58752783
31MP0003252_abnormal_bile_duct1.58185123
32MP0001968_abnormal_touch/_nociception1.55796946
33MP0005365_abnormal_bile_salt1.49073055
34MP0003111_abnormal_nucleus_morphology1.38033916
35MP0005360_urolithiasis1.37713259
36MP0002736_abnormal_nociception_after1.37487727
37MP0008932_abnormal_embryonic_tissue1.37184437
38MP0002160_abnormal_reproductive_system1.36898475
39MP0003011_delayed_dark_adaptation1.34083535
40MP0005253_abnormal_eye_physiology1.23864421
41MP0001486_abnormal_startle_reflex1.19247228
42MP0005075_abnormal_melanosome_morpholog1.13633755
43MP0008057_abnormal_DNA_replication1.12448842
44MP0005174_abnormal_tail_pigmentation1.12356978
45MP0009053_abnormal_anal_canal1.11853354
46MP0003119_abnormal_digestive_system1.08104178
47MP0005083_abnormal_biliary_tract1.06382924
48MP0004233_abnormal_muscle_weight1.05171181
49MP0003880_abnormal_central_pattern1.04220471
50MP0001963_abnormal_hearing_physiology1.04189559
51MP0010368_abnormal_lymphatic_system1.04004825
52MP0003045_fibrosis0.99317529
53MP0000678_abnormal_parathyroid_gland0.96887558
54MP0000427_abnormal_hair_cycle0.96018810
55MP0000383_abnormal_hair_follicle0.95650370
56MP0002272_abnormal_nervous_system0.95153547
57MP0005379_endocrine/exocrine_gland_phen0.94624228
58MP0005647_abnormal_sex_gland0.93687050
59MP0002796_impaired_skin_barrier0.93373885
60MP0006292_abnormal_olfactory_placode0.92082089
61MP0005645_abnormal_hypothalamus_physiol0.90192234
62MP0010307_abnormal_tumor_latency0.89741797
63MP0001348_abnormal_lacrimal_gland0.88000241
64MP0009745_abnormal_behavioral_response0.86103066
65MP0002735_abnormal_chemical_nociception0.85819137
66MP0003699_abnormal_female_reproductive0.84618331
67MP0002095_abnormal_skin_pigmentation0.83644600
68MP0001730_embryonic_growth_arrest0.82820354
69MP0009697_abnormal_copulation0.82708577
70MP0002229_neurodegeneration0.81785498
71MP0002234_abnormal_pharynx_morphology0.81435855
72MP0002254_reproductive_system_inflammat0.79873069
73MP0004147_increased_porphyrin_level0.76679009
74MP0008004_abnormal_stomach_pH0.74935282
75MP0008789_abnormal_olfactory_epithelium0.74188795
76MP0001501_abnormal_sleep_pattern0.73861483
77MP0003959_abnormal_lean_body0.72758975
78MP0006276_abnormal_autonomic_nervous0.72706736
79MP0004782_abnormal_surfactant_physiolog0.70683830
80MP0003937_abnormal_limbs/digits/tail_de0.70038791
81MP0002928_abnormal_bile_duct0.69343257
82MP0005389_reproductive_system_phenotype0.69236545
83MP0001664_abnormal_digestion0.68994613
84MP0002163_abnormal_gland_morphology0.68533551
85MP0008770_decreased_survivor_rate0.67457403
86MP0008872_abnormal_physiological_respon0.67244134
87MP0000749_muscle_degeneration0.66759578
88MP0001324_abnormal_eye_pigmentation0.66594428
89MP0010678_abnormal_skin_adnexa0.66557351
90MP0000569_abnormal_digit_pigmentation0.65747404
91MP0008260_abnormal_autophagy0.64760297
92MP0000579_abnormal_nail_morphology0.63741723
93MP0000026_abnormal_inner_ear0.63614085
94MP0002084_abnormal_developmental_patter0.62257655
95MP0005423_abnormal_somatic_nervous0.61672827
96MP0000015_abnormal_ear_pigmentation0.61495995
97MP0001485_abnormal_pinna_reflex0.61262438
98MP0001119_abnormal_female_reproductive0.60882312
99MP0006035_abnormal_mitochondrial_morpho0.60875362
100MP0002085_abnormal_embryonic_tissue0.60241679

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)4.80117855
2Severe visual impairment (HP:0001141)4.38044633
3Osteomalacia (HP:0002749)4.07991356
4Chronic hepatic failure (HP:0100626)3.75921503
5Thyroid-stimulating hormone excess (HP:0002925)3.60684434
6Volvulus (HP:0002580)3.38485992
7Male infertility (HP:0003251)3.36782666
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19599165
9Attenuation of retinal blood vessels (HP:0007843)3.14155954
10Hypophosphatemic rickets (HP:0004912)3.13477318
11Conjunctival telangiectasia (HP:0000524)3.13190532
12Supernumerary spleens (HP:0009799)3.12272531
13Abnormality of macular pigmentation (HP:0008002)3.12103610
14Abnormality of the labia minora (HP:0012880)3.09464635
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.08007990
16Absent/shortened dynein arms (HP:0200106)3.08007990
17Aplasia/Hypoplasia of the fovea (HP:0008060)3.05184352
18Hypoplasia of the fovea (HP:0007750)3.05184352
19Cone-rod dystrophy (HP:0000548)3.02401043
20Bony spicule pigmentary retinopathy (HP:0007737)2.98475585
21Type II lissencephaly (HP:0007260)2.97292463
22Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.94434269
23Impulsivity (HP:0100710)2.89296066
24Abnormal respiratory motile cilium physiology (HP:0012261)2.86310641
25Chromsome breakage (HP:0040012)2.83834078
26Optic nerve hypoplasia (HP:0000609)2.77444059
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.75906148
28Abnormal ciliary motility (HP:0012262)2.73753117
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.71290213
30Pendular nystagmus (HP:0012043)2.68446095
31Intrahepatic cholestasis (HP:0001406)2.66489440
32Hyperkalemia (HP:0002153)2.64859686
33Conjugated hyperbilirubinemia (HP:0002908)2.57335984
34Tubulointerstitial nephritis (HP:0001970)2.57297820
35Abnormality of lateral ventricle (HP:0030047)2.48958649
36Abnormal spermatogenesis (HP:0008669)2.48284897
37Anterior segment dysgenesis (HP:0007700)2.43312838
38Pancreatic cysts (HP:0001737)2.40648527
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.39848289
40Aplasia/Hypoplasia of the earlobes (HP:0009906)2.38879947
41Infertility (HP:0000789)2.37352928
42Abnormality of the ileum (HP:0001549)2.37036025
43Subcapsular cataract (HP:0000523)2.36592933
44Abnormality of the vasculature of the conjunctiva (HP:0008054)2.34624927
45Abnormality of the fovea (HP:0000493)2.34201857
46Tubular atrophy (HP:0000092)2.32590280
47Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.31601342
48Abnormality of the costochondral junction (HP:0000919)2.31001682
49Nephronophthisis (HP:0000090)2.29159138
50Truncal obesity (HP:0001956)2.29103428
51Azoospermia (HP:0000027)2.26183484
52Abnormality of abdominal situs (HP:0011620)2.25923059
53Abdominal situs inversus (HP:0003363)2.25923059
54Abnormal rod and cone electroretinograms (HP:0008323)2.25015997
55Abnormal respiratory motile cilium morphology (HP:0005938)2.23509100
56Abnormal respiratory epithelium morphology (HP:0012253)2.23509100
57Focal motor seizures (HP:0011153)2.22574770
58Median cleft lip (HP:0000161)2.22568499
59Hyperglycinemia (HP:0002154)2.19954521
60Colon cancer (HP:0003003)2.19551512
61Horizontal nystagmus (HP:0000666)2.16493498
62Aplasia/Hypoplasia of the tibia (HP:0005772)2.13014024
63Chronic bronchitis (HP:0004469)2.12387356
64Cerebellar dysplasia (HP:0007033)2.11013955
65Pancreatic fibrosis (HP:0100732)2.09829248
66Neonatal respiratory distress (HP:0002643)2.09361782
67Acanthocytosis (HP:0001927)2.09144369
68Retinal dysplasia (HP:0007973)2.08894469
69Decreased central vision (HP:0007663)2.06134370
70Rickets (HP:0002748)2.06087249
71Asymmetric septal hypertrophy (HP:0001670)2.04133059
72Abnormality of the renal medulla (HP:0100957)2.01332307
73Photophobia (HP:0000613)2.01120582
74Duodenal stenosis (HP:0100867)1.99466460
75Small intestinal stenosis (HP:0012848)1.99466460
76Abnormality of dental color (HP:0011073)1.97741468
77Metaphyseal irregularity (HP:0003025)1.97342997
78Meckel diverticulum (HP:0002245)1.97038668
79Hyperglycinuria (HP:0003108)1.96834669
80Rhinitis (HP:0012384)1.93922163
81Tubulointerstitial abnormality (HP:0001969)1.93050524
82Scotoma (HP:0000575)1.89773148
83Congenital ichthyosiform erythroderma (HP:0007431)1.87493830
84Portal hypertension (HP:0001409)1.86854177
85Short tibia (HP:0005736)1.85839671
86Delayed epiphyseal ossification (HP:0002663)1.82577024
87Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81004855
88Abnormal drinking behavior (HP:0030082)1.80915953
89Polydipsia (HP:0001959)1.80915953
90Intestinal atresia (HP:0011100)1.80347365
91Aplasia/Hypoplasia of the macula (HP:0008059)1.78889839
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.78815657
93Abnormality of potassium homeostasis (HP:0011042)1.77652262
94Abnormality of purine metabolism (HP:0004352)1.77511253
95Petechiae (HP:0000967)1.76951854
96Dialeptic seizures (HP:0011146)1.76179754
97Split foot (HP:0001839)1.75318875
98Peripheral hypomyelination (HP:0007182)1.73848824
99Pili torti (HP:0003777)1.73640371
100Stage 5 chronic kidney disease (HP:0003774)1.72637290

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.70647262
2STK38L4.96312291
3LATS13.59145555
4ARAF2.96521609
5PBK2.95238272
6ZAK2.75259429
7LATS22.71413525
8ACVR1B2.71235168
9TTK2.19912656
10INSRR2.18674928
11CDK192.14785330
12PLK22.09061446
13ADRBK22.05608006
14MAP4K22.02999455
15CDC71.93667200
16STK381.84402690
17BRAF1.76989266
18NEK61.62684536
19STK31.58950826
20LMTK21.47134651
21PRKD31.45019393
22PIK3CG1.43835097
23MAP3K101.36012833
24PLK11.30694473
25FRK1.26649872
26STK241.25074040
27BMPR1B1.24429754
28PNCK1.23445783
29BUB11.10668696
30BRSK11.08817967
31TYRO31.07705330
32KSR21.06295582
33MAP3K91.05200780
34PDK21.02932938
35EIF2AK31.01197978
36AURKA1.00863040
37BRD41.00379547
38STK390.98397924
39WNK40.96948573
40PRKCI0.95204702
41BMX0.90697416
42PIM20.89904236
43MELK0.88938710
44PINK10.88783297
45MKNK20.86667236
46CHEK20.79407637
47GRK10.79091315
48RAF10.78874244
49PLK30.77736353
50TEC0.73816368
51BRSK20.72648559
52CDK70.72480281
53WNK10.71750708
54TIE10.71006976
55TAOK30.70929858
56MAP2K20.69141787
57PRKG20.66383925
58MET0.66160866
59DDR20.65291211
60PHKG20.64685944
61PHKG10.64685944
62PTK2B0.64415441
63STK160.63547988
64PRKCG0.63222281
65MOS0.60844181
66MAP3K80.59713408
67PIM10.58236382
68ADRBK10.56414193
69NTRK30.54811721
70OXSR10.54789360
71NEK20.53893787
72MAP3K20.52997035
73PDPK10.52180408
74VRK10.52146994
75VRK20.48212546
76MST1R0.47690684
77DYRK30.47131324
78PRKCE0.46895056
79SRPK10.43666873
80TESK10.43200927
81CDK20.42589154
82CHEK10.41873913
83CDK10.41034737
84NME10.40608853
85EIF2AK10.40357840
86PKN10.39087284
87AURKB0.38205880
88ATM0.37058564
89PDK10.35770598
90PRKG10.35257923
91TRIM280.34931577
92ATR0.34626398
93MAP3K40.33677822
94TGFBR10.32400748
95MST40.31894210
96PRKACA0.30938362
97CDK120.30650525
98PAK10.29241544
99CAMK2A0.28868093
100GSK3B0.28834634

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.99957620
2Basal transcription factors_Homo sapiens_hsa030222.92970731
3Phototransduction_Homo sapiens_hsa047442.85370732
4Mismatch repair_Homo sapiens_hsa034302.82307483
5DNA replication_Homo sapiens_hsa030302.49487689
6ABC transporters_Homo sapiens_hsa020102.34834939
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28907367
8Fanconi anemia pathway_Homo sapiens_hsa034602.26283846
9Cell cycle_Homo sapiens_hsa041102.25438476
10Caffeine metabolism_Homo sapiens_hsa002322.20091358
11RNA transport_Homo sapiens_hsa030132.15964695
12One carbon pool by folate_Homo sapiens_hsa006702.14966527
13beta-Alanine metabolism_Homo sapiens_hsa004102.14024961
14Homologous recombination_Homo sapiens_hsa034402.06533755
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.05184115
16Base excision repair_Homo sapiens_hsa034102.00202267
17Fatty acid biosynthesis_Homo sapiens_hsa000611.94362957
18Arginine and proline metabolism_Homo sapiens_hsa003301.93346906
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.91215044
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88981001
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78597282
22Dorso-ventral axis formation_Homo sapiens_hsa043201.75566144
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74752767
24Folate biosynthesis_Homo sapiens_hsa007901.73058554
25Nicotine addiction_Homo sapiens_hsa050331.69967928
26Fatty acid degradation_Homo sapiens_hsa000711.58750030
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57174999
28Glycerolipid metabolism_Homo sapiens_hsa005611.55873406
29Oocyte meiosis_Homo sapiens_hsa041141.50161117
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46880019
31Taste transduction_Homo sapiens_hsa047421.38085030
32Non-homologous end-joining_Homo sapiens_hsa034501.37234370
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.34083468
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.32725839
35Nucleotide excision repair_Homo sapiens_hsa034201.25822774
36Regulation of autophagy_Homo sapiens_hsa041401.22473074
37Histidine metabolism_Homo sapiens_hsa003401.21194654
38Tryptophan metabolism_Homo sapiens_hsa003801.15179335
39Butanoate metabolism_Homo sapiens_hsa006501.13600378
40Morphine addiction_Homo sapiens_hsa050321.11060253
41RNA polymerase_Homo sapiens_hsa030201.07749062
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06437270
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05923735
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04642237
45RNA degradation_Homo sapiens_hsa030181.03503895
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97309407
47Propanoate metabolism_Homo sapiens_hsa006400.93477361
48Steroid biosynthesis_Homo sapiens_hsa001000.92997868
49Purine metabolism_Homo sapiens_hsa002300.91635392
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85650537
51Sphingolipid metabolism_Homo sapiens_hsa006000.83572668
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82056575
53Pyrimidine metabolism_Homo sapiens_hsa002400.81447546
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77299365
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76653775
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.76370667
57Bile secretion_Homo sapiens_hsa049760.76018478
58Fatty acid metabolism_Homo sapiens_hsa012120.74200424
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71813543
60mRNA surveillance pathway_Homo sapiens_hsa030150.71132875
61Arachidonic acid metabolism_Homo sapiens_hsa005900.70932017
62Linoleic acid metabolism_Homo sapiens_hsa005910.68394273
63Fatty acid elongation_Homo sapiens_hsa000620.66920550
64Serotonergic synapse_Homo sapiens_hsa047260.65933122
65Retinol metabolism_Homo sapiens_hsa008300.65377190
66Nitrogen metabolism_Homo sapiens_hsa009100.63727597
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59869770
68Metabolic pathways_Homo sapiens_hsa011000.59074177
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58544055
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56665973
71Phenylalanine metabolism_Homo sapiens_hsa003600.56331132
72Huntingtons disease_Homo sapiens_hsa050160.56057130
73GABAergic synapse_Homo sapiens_hsa047270.52874088
74Long-term depression_Homo sapiens_hsa047300.51505799
75Ovarian steroidogenesis_Homo sapiens_hsa049130.50260787
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49814965
77Arginine biosynthesis_Homo sapiens_hsa002200.49567276
78Selenocompound metabolism_Homo sapiens_hsa004500.47079495
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46249750
80Hedgehog signaling pathway_Homo sapiens_hsa043400.44602208
81Sulfur relay system_Homo sapiens_hsa041220.44319102
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.44207737
83Glutathione metabolism_Homo sapiens_hsa004800.41791333
84Cardiac muscle contraction_Homo sapiens_hsa042600.41072322
85Calcium signaling pathway_Homo sapiens_hsa040200.39960410
86TGF-beta signaling pathway_Homo sapiens_hsa043500.38660328
87Vitamin digestion and absorption_Homo sapiens_hsa049770.38311655
88Proteasome_Homo sapiens_hsa030500.37752178
89Lysine degradation_Homo sapiens_hsa003100.36837438
90Circadian rhythm_Homo sapiens_hsa047100.35697850
91p53 signaling pathway_Homo sapiens_hsa041150.35635824
92Hippo signaling pathway_Homo sapiens_hsa043900.34959193
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34822742
94Chemical carcinogenesis_Homo sapiens_hsa052040.33810911
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32736584
96Basal cell carcinoma_Homo sapiens_hsa052170.32150730
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.32139318
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30506635
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30329429
100cAMP signaling pathway_Homo sapiens_hsa040240.28741021

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