C4orf19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)5.42712455
2drug catabolic process (GO:0042737)5.22313365
3epoxygenase P450 pathway (GO:0019373)5.07386051
4cellular glucuronidation (GO:0052695)4.57379025
5uronic acid metabolic process (GO:0006063)4.51093127
6glucuronate metabolic process (GO:0019585)4.51093127
7cellular ketone body metabolic process (GO:0046950)4.25658047
8flavonoid metabolic process (GO:0009812)4.05021430
9ketone body metabolic process (GO:1902224)4.05007994
10fucose catabolic process (GO:0019317)4.02042773
11L-fucose metabolic process (GO:0042354)4.02042773
12L-fucose catabolic process (GO:0042355)4.02042773
13prostate gland growth (GO:0060736)3.95368600
14regulation of triglyceride catabolic process (GO:0010896)3.94588497
15arginine metabolic process (GO:0006525)3.92813214
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.87912547
17omega-hydroxylase P450 pathway (GO:0097267)3.85650142
18drug metabolic process (GO:0017144)3.85071581
19intestinal absorption (GO:0050892)3.76958263
20pyrimidine-containing compound transmembrane transport (GO:0072531)3.71438410
21oxidative demethylation (GO:0070989)3.60615641
22bile acid and bile salt transport (GO:0015721)3.55751665
23indole-containing compound catabolic process (GO:0042436)3.55639993
24indolalkylamine catabolic process (GO:0046218)3.55639993
25tryptophan catabolic process (GO:0006569)3.55639993
26cilium or flagellum-dependent cell motility (GO:0001539)3.48811720
27bile acid metabolic process (GO:0008206)3.47612932
28calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.46700655
29piRNA metabolic process (GO:0034587)3.45867775
30phenylpropanoid metabolic process (GO:0009698)3.32163011
31alkaloid metabolic process (GO:0009820)3.31900004
32quinone biosynthetic process (GO:1901663)3.28245884
33epithelial cilium movement (GO:0003351)3.24682554
34glyoxylate metabolic process (GO:0046487)3.23109428
35water-soluble vitamin biosynthetic process (GO:0042364)3.22537849
36S-adenosylmethionine metabolic process (GO:0046500)3.21763688
37axoneme assembly (GO:0035082)3.17611961
38tryptophan metabolic process (GO:0006568)3.15301434
39digestion (GO:0007586)3.15164376
40preassembly of GPI anchor in ER membrane (GO:0016254)3.13956403
41drug transmembrane transport (GO:0006855)3.12263096
42xenobiotic catabolic process (GO:0042178)3.11239856
43cilium movement (GO:0003341)3.10687339
44vitamin transmembrane transport (GO:0035461)3.10421979
45aromatic amino acid family catabolic process (GO:0009074)3.08691314
46intestinal cholesterol absorption (GO:0030299)3.06474331
47indolalkylamine metabolic process (GO:0006586)3.03774290
48regulation of acrosome reaction (GO:0060046)3.02844973
49bile acid biosynthetic process (GO:0006699)3.00919654
50intestinal epithelial cell development (GO:0060576)2.98696804
51axonemal dynein complex assembly (GO:0070286)2.96851958
52regulation of guanylate cyclase activity (GO:0031282)2.93905265
53regulation of hippo signaling (GO:0035330)2.93743766
54kynurenine metabolic process (GO:0070189)2.92788938
55ethanol oxidation (GO:0006069)2.91636007
56mannosylation (GO:0097502)2.91046914
57heme transport (GO:0015886)2.90496712
58phosphatidylinositol acyl-chain remodeling (GO:0036149)2.89545669
59amino-acid betaine metabolic process (GO:0006577)2.86333106
603-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.86171876
61purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.86171876
62sulfur amino acid catabolic process (GO:0000098)2.85451011
63sulfur compound transport (GO:0072348)2.85343126
64vitamin biosynthetic process (GO:0009110)2.84362709
65fucosylation (GO:0036065)2.82530380
66nucleotide transmembrane transport (GO:1901679)2.82206435
67arginine catabolic process (GO:0006527)2.81840548
68ethanol metabolic process (GO:0006067)2.81530130
69behavioral response to nicotine (GO:0035095)2.81353712
70response to nitrosative stress (GO:0051409)2.80221039
71vitamin transport (GO:0051180)2.77810020
72benzene-containing compound metabolic process (GO:0042537)2.76066154
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74929760
74quinone metabolic process (GO:1901661)2.73985911
75transepithelial transport (GO:0070633)2.73584923
76L-methionine biosynthetic process (GO:0071265)2.73409900
77amino acid salvage (GO:0043102)2.73409900
78L-methionine salvage (GO:0071267)2.73409900
79DNA methylation involved in gamete generation (GO:0043046)2.71824081
80drug transport (GO:0015893)2.71184147
81xenobiotic metabolic process (GO:0006805)2.70946421
82primary alcohol catabolic process (GO:0034310)2.70112996
83positive regulation of fatty acid transport (GO:2000193)2.67643183
84positive regulation of icosanoid secretion (GO:0032305)2.66823918
85transcytosis (GO:0045056)2.61860702
86short-chain fatty acid metabolic process (GO:0046459)2.58892652
87glycerol metabolic process (GO:0006071)2.58504821
88DNA deamination (GO:0045006)2.57441842
89phosphatidylserine acyl-chain remodeling (GO:0036150)2.57341964
90auditory receptor cell stereocilium organization (GO:0060088)2.57319015
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.55874050
92L-phenylalanine catabolic process (GO:0006559)2.55874050
93ubiquinone biosynthetic process (GO:0006744)2.55440336
94glutathione derivative metabolic process (GO:1901685)2.53083658
95glutathione derivative biosynthetic process (GO:1901687)2.53083658
96GPI anchor metabolic process (GO:0006505)2.52549966
97multicellular organism reproduction (GO:0032504)2.49658753
98photoreceptor cell maintenance (GO:0045494)2.49402793
99macroautophagy (GO:0016236)2.48765510
100urate metabolic process (GO:0046415)2.48301336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_20079471_ChIP-ChIP_T-47D_Human3.61640656
2ZNF274_21170338_ChIP-Seq_K562_Hela3.34868102
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.19236461
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.16854825
5VDR_22108803_ChIP-Seq_LS180_Human2.69335312
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.66826370
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21265316
8GATA4_25053715_ChIP-Seq_YYC3_Human2.05025213
9ER_23166858_ChIP-Seq_MCF-7_Human1.98949744
10CDX2_20551321_ChIP-Seq_CACO-2_Human1.96295580
11FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.92861349
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.86223112
13RXR_22158963_ChIP-Seq_LIVER_Mouse1.75028023
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.71262971
15BCAT_22108803_ChIP-Seq_LS180_Human1.64696675
16LXR_22158963_ChIP-Seq_LIVER_Mouse1.62831369
17AHR_22903824_ChIP-Seq_MCF-7_Human1.61510652
18AR_20517297_ChIP-Seq_VCAP_Human1.60006443
19* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.59755452
20GBX2_23144817_ChIP-Seq_PC3_Human1.59312449
21FOXA1_27270436_Chip-Seq_PROSTATE_Human1.59272533
22FOXA1_25329375_ChIP-Seq_VCAP_Human1.59272533
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.57605112
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57372841
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57072346
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55747590
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55588645
28* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55437771
29HOXB7_26014856_ChIP-Seq_BT474_Human1.53469048
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53385329
31PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53282238
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52622500
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52588189
34* CDX2_22108803_ChIP-Seq_LS180_Human1.51989617
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51560850
36CBP_20019798_ChIP-Seq_JUKART_Human1.51560850
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50014978
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.49660368
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48741940
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48018264
41FOXA1_21572438_ChIP-Seq_LNCaP_Human1.47588034
42AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.45037663
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44744558
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.41808828
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.41468350
46IRF1_19129219_ChIP-ChIP_H3396_Human1.41040781
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38951668
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.38682983
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.38400744
50PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.36272999
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.34956650
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34644258
53TP53_22573176_ChIP-Seq_HFKS_Human1.32656159
54GATA6_25053715_ChIP-Seq_YYC3_Human1.31956351
55FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.29728434
56P300_19829295_ChIP-Seq_ESCs_Human1.29661554
57HTT_18923047_ChIP-ChIP_STHdh_Human1.28829237
58* FOXA1_25552417_ChIP-Seq_VCAP_Human1.27630842
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.26777288
60TCF4_22108803_ChIP-Seq_LS180_Human1.25879632
61NCOR_22424771_ChIP-Seq_293T_Human1.25159397
62AR_25329375_ChIP-Seq_VCAP_Human1.24393224
63IGF1R_20145208_ChIP-Seq_DFB_Human1.23039374
64* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20924056
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17312045
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16368719
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15844969
68* TCF4_23295773_ChIP-Seq_U87_Human1.14913526
69STAT3_23295773_ChIP-Seq_U87_Human1.14651406
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14496866
71CBP_21632823_ChIP-Seq_H3396_Human1.14362217
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14323899
73NANOG_20526341_ChIP-Seq_ESCs_Human1.12593102
74ERG_20517297_ChIP-Seq_VCAP_Human1.12082333
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10326812
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09955360
77P53_21459846_ChIP-Seq_SAOS-2_Human1.09872398
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09555926
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08111113
80* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.07361420
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06912759
82* SOX2_20726797_ChIP-Seq_SW620_Human1.06394493
83* ELF5_23300383_ChIP-Seq_T47D_Human1.05863935
84* SOX2_19829295_ChIP-Seq_ESCs_Human1.05835925
85* NANOG_19829295_ChIP-Seq_ESCs_Human1.05835925
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05359995
87IRF8_22096565_ChIP-ChIP_GC-B_Human1.03969194
88ERA_21632823_ChIP-Seq_H3396_Human1.03867910
89HNF4A_19822575_ChIP-Seq_HepG2_Human1.03587384
90GABP_17652178_ChIP-ChIP_JURKAT_Human1.03455095
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.03437995
92TAF2_19829295_ChIP-Seq_ESCs_Human1.03425717
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02551821
94SMAD4_21799915_ChIP-Seq_A2780_Human1.02317464
95CEBPB_22108803_ChIP-Seq_LS180_Human1.00412072
96FOXH1_21741376_ChIP-Seq_EPCs_Human1.00220081
97TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99310391
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.98955968
99KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94543877
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94167426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.07528986
2MP0005360_urolithiasis3.96468785
3MP0005085_abnormal_gallbladder_physiolo3.96412060
4MP0005365_abnormal_bile_salt3.65839770
5MP0001666_abnormal_nutrient_absorption3.56542253
6MP0010234_abnormal_vibrissa_follicle3.47916245
7MP0008875_abnormal_xenobiotic_pharmacok3.26710990
8MP0002876_abnormal_thyroid_physiology3.09400376
9MP0003195_calcinosis3.08501662
10MP0004147_increased_porphyrin_level2.77248201
11MP0002254_reproductive_system_inflammat2.58150124
12MP0000427_abnormal_hair_cycle2.52394917
13MP0002138_abnormal_hepatobiliary_system2.51596158
14MP0004264_abnormal_extraembryonic_tissu2.46925244
15MP0003252_abnormal_bile_duct2.34989718
16MP0010329_abnormal_lipoprotein_level2.30918125
17MP0003718_maternal_effect2.25194811
18MP0004019_abnormal_vitamin_homeostasis2.24671194
19MP0004043_abnormal_pH_regulation2.10146355
20MP0003806_abnormal_nucleotide_metabolis2.04394303
21MP0003183_abnormal_peptide_metabolism2.01100802
22MP0010678_abnormal_skin_adnexa1.95559336
23MP0005408_hypopigmentation1.91571927
24MP0005083_abnormal_biliary_tract1.88346217
25MP0002098_abnormal_vibrissa_morphology1.80336171
26MP0008872_abnormal_physiological_respon1.78529278
27MP0001664_abnormal_digestion1.75231905
28MP0000383_abnormal_hair_follicle1.74358133
29MP0003868_abnormal_feces_composition1.72562800
30MP0000566_synostosis1.69466994
31MP0005636_abnormal_mineral_homeostasis1.68568052
32MP0001765_abnormal_ion_homeostasis1.65898279
33MP0009780_abnormal_chondrocyte_physiolo1.64572536
34MP0005379_endocrine/exocrine_gland_phen1.62717589
35MP0001346_abnormal_lacrimal_gland1.60256947
36MP0005332_abnormal_amino_acid1.57295065
37MP0008877_abnormal_DNA_methylation1.51797842
38MP0005248_abnormal_Harderian_gland1.47847895
39MP0005551_abnormal_eye_electrophysiolog1.46077225
40MP0001919_abnormal_reproductive_system1.45323032
41MP0004782_abnormal_surfactant_physiolog1.44778856
42MP0001764_abnormal_homeostasis1.43778289
43MP0002653_abnormal_ependyma_morphology1.38226353
44MP0002102_abnormal_ear_morphology1.36163383
45MP0009643_abnormal_urine_homeostasis1.35499929
46MP0003011_delayed_dark_adaptation1.34246703
47MP0005646_abnormal_pituitary_gland1.22699836
48MP0002118_abnormal_lipid_homeostasis1.22682752
49MP0009840_abnormal_foam_cell1.19886593
50MP0002909_abnormal_adrenal_gland1.19062665
51MP0001873_stomach_inflammation1.18298634
52MP0001881_abnormal_mammary_gland1.10346651
53MP0005389_reproductive_system_phenotype1.09560396
54MP0005645_abnormal_hypothalamus_physiol1.04849746
55MP0005395_other_phenotype1.04591600
56MP0001756_abnormal_urination1.01771839
57MP0002796_impaired_skin_barrier1.00220792
58MP0003638_abnormal_response/metabolism_0.98128184
59MP0005319_abnormal_enzyme/_coenzyme0.94916205
60MP0005377_hearing/vestibular/ear_phenot0.93702304
61MP0003878_abnormal_ear_physiology0.93702304
62MP0005253_abnormal_eye_physiology0.93658256
63MP0003866_abnormal_defecation0.93266440
64MP0005075_abnormal_melanosome_morpholog0.91204390
65MP0005174_abnormal_tail_pigmentation0.90286189
66MP0000372_irregular_coat_pigmentation0.84685026
67MP0001501_abnormal_sleep_pattern0.84211230
68MP0001986_abnormal_taste_sensitivity0.84176469
69MP0002282_abnormal_trachea_morphology0.84070099
70MP0000470_abnormal_stomach_morphology0.83292738
71MP0003646_muscle_fatigue0.82743605
72MP0000627_abnormal_mammary_gland0.81010510
73MP0001944_abnormal_pancreas_morphology0.80855162
74MP0006072_abnormal_retinal_apoptosis0.80122570
75MP0003953_abnormal_hormone_level0.79364302
76MP0000609_abnormal_liver_physiology0.79265514
77MP0003936_abnormal_reproductive_system0.77085938
78MP0000377_abnormal_hair_follicle0.76582335
79MP0000647_abnormal_sebaceous_gland0.75998204
80MP0005084_abnormal_gallbladder_morpholo0.75257138
81MP0002136_abnormal_kidney_physiology0.72543319
82MP0010155_abnormal_intestine_physiology0.67278180
83MP0005448_abnormal_energy_balance0.66421098
84MP0002277_abnormal_respiratory_mucosa0.65434671
85MP0001485_abnormal_pinna_reflex0.63162074
86MP0000230_abnormal_systemic_arterial0.62116480
87MP0002160_abnormal_reproductive_system0.61779606
88MP0002928_abnormal_bile_duct0.60935607
89MP0002693_abnormal_pancreas_physiology0.60055117
90MP0009642_abnormal_blood_homeostasis0.58874704
91MP0001663_abnormal_digestive_system0.58560199
92MP0003186_abnormal_redox_activity0.58438474
93MP0001324_abnormal_eye_pigmentation0.58343656
94MP0005670_abnormal_white_adipose0.56961904
95MP0006276_abnormal_autonomic_nervous0.56566246
96MP0000467_abnormal_esophagus_morphology0.55351840
97MP0002078_abnormal_glucose_homeostasis0.55023766
98MP0003879_abnormal_hair_cell0.53666969
99MP0005410_abnormal_fertilization0.53157122
100MP0001929_abnormal_gametogenesis0.52872344

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)4.10801493
2Concave nail (HP:0001598)3.69212198
3Decreased circulating renin level (HP:0003351)3.63889401
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.48911540
5Abnormality of the renal cortex (HP:0011035)3.42565670
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.25736801
7Absent/shortened dynein arms (HP:0200106)3.25736801
8Hyperglycinuria (HP:0003108)3.15713013
9Hyperactive renin-angiotensin system (HP:0000841)3.12800239
10Hydroxyprolinuria (HP:0003080)3.09064750
11Abnormality of proline metabolism (HP:0010907)3.09064750
12Type II lissencephaly (HP:0007260)3.02576298
13Abnormality of midbrain morphology (HP:0002418)3.00930924
14Molar tooth sign on MRI (HP:0002419)3.00930924
15Pancreatic cysts (HP:0001737)2.99588987
16Fat malabsorption (HP:0002630)2.94220044
17Glycosuria (HP:0003076)2.89408276
18Abnormality of urine glucose concentration (HP:0011016)2.89408276
19Abnormality of renin-angiotensin system (HP:0000847)2.85546406
20Tubular atrophy (HP:0000092)2.82304116
21Intrahepatic cholestasis (HP:0001406)2.80995223
22Abnormality of serine family amino acid metabolism (HP:0010894)2.79727215
23Abnormality of glycine metabolism (HP:0010895)2.79727215
24Abnormal respiratory motile cilium morphology (HP:0005938)2.69112653
25Abnormal respiratory epithelium morphology (HP:0012253)2.69112653
26Chronic hepatic failure (HP:0100626)2.68622988
27Alkalosis (HP:0001948)2.63053118
28Congenital stationary night blindness (HP:0007642)2.59395575
29Hypobetalipoproteinemia (HP:0003563)2.56013997
30Abnormal ciliary motility (HP:0012262)2.55508947
31Pancreatic fibrosis (HP:0100732)2.48063415
32Conjugated hyperbilirubinemia (HP:0002908)2.46598027
33Steatorrhea (HP:0002570)2.46410450
34Nephronophthisis (HP:0000090)2.45153357
35Abnormality of the renal medulla (HP:0100957)2.45094223
36Congenital sensorineural hearing impairment (HP:0008527)2.44625609
37Pigmentary retinal degeneration (HP:0001146)2.44300669
38Renal cortical cysts (HP:0000803)2.43939165
39Metabolic alkalosis (HP:0200114)2.43798200
40Ketosis (HP:0001946)2.43431411
41Delayed CNS myelination (HP:0002188)2.41212513
42Abnormal biliary tract physiology (HP:0012439)2.39710491
43Bile duct proliferation (HP:0001408)2.39710491
44Hyperammonemia (HP:0001987)2.35914137
45Attenuation of retinal blood vessels (HP:0007843)2.31815946
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.30293201
47Abolished electroretinogram (ERG) (HP:0000550)2.29959008
48Stomach cancer (HP:0012126)2.29744885
49Abnormality of vitamin B metabolism (HP:0004340)2.27295337
50True hermaphroditism (HP:0010459)2.27172145
51Hyperaldosteronism (HP:0000859)2.26609724
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26386799
53Decreased central vision (HP:0007663)2.25715371
54Abnormal respiratory motile cilium physiology (HP:0012261)2.24537320
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23826605
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.23105228
57Abnormality of the vitamin B12 metabolism (HP:0004341)2.22529204
58Polydipsia (HP:0001959)2.20834981
59Abnormal drinking behavior (HP:0030082)2.20834981
60Tubulointerstitial nephritis (HP:0001970)2.16609178
61Abnormality of vitamin metabolism (HP:0100508)2.11318084
62Proximal tubulopathy (HP:0000114)2.07833702
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05565961
64Abnormality of alanine metabolism (HP:0010916)2.05565961
65Hyperalaninemia (HP:0003348)2.05565961
66Medial flaring of the eyebrow (HP:0010747)2.04356602
67Cerebellar dysplasia (HP:0007033)2.04158944
68Abnormality of the proximal phalanges of the hand (HP:0009834)2.01574756
69Lethargy (HP:0001254)2.00837994
70Metabolic acidosis (HP:0001942)2.00678022
71Generalized aminoaciduria (HP:0002909)2.00567505
72Abnormality of renal excretion (HP:0011036)2.00506396
73Hyperglycinemia (HP:0002154)2.00070116
74Amelogenesis imperfecta (HP:0000705)1.99920825
75Ketoacidosis (HP:0001993)1.99778191
76Prolonged partial thromboplastin time (HP:0003645)1.99607515
77Azoospermia (HP:0000027)1.97010927
78Large for gestational age (HP:0001520)1.96547038
79Flat capital femoral epiphysis (HP:0003370)1.93775197
80Chronic bronchitis (HP:0004469)1.91647785
81Hyperphosphaturia (HP:0003109)1.91265476
82Cystic liver disease (HP:0006706)1.90900421
83Rhinitis (HP:0012384)1.90421512
84Abnormal rod and cone electroretinograms (HP:0008323)1.89574286
85Hepatic necrosis (HP:0002605)1.87565896
86Tongue fasciculations (HP:0001308)1.82891210
87Aplasia/Hypoplasia of the tibia (HP:0005772)1.82464063
88Abnormality of aromatic amino acid family metabolism (HP:0004338)1.81374169
89Oligomenorrhea (HP:0000876)1.80406313
90Abnormality of chloride homeostasis (HP:0011422)1.77429294
91Polyuria (HP:0000103)1.77044337
92Abnormality of serum amino acid levels (HP:0003112)1.76811007
93Abnormality of pyrimidine metabolism (HP:0004353)1.76784174
94Cerebral palsy (HP:0100021)1.74915315
95Fair hair (HP:0002286)1.74511529
96Abnormal urine output (HP:0012590)1.74474039
97Breast carcinoma (HP:0003002)1.73227103
98Widely patent fontanelles and sutures (HP:0004492)1.70739201
99Severe muscular hypotonia (HP:0006829)1.70270764
100Dicarboxylic aciduria (HP:0003215)1.70155796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.14452469
2ACVR1B3.80589737
3EPHA23.42684089
4BMPR1B3.25875713
5TAOK32.82467449
6MAPKAPK32.75168742
7PINK12.74104617
8ADRBK22.41149840
9PIK3CA2.37266888
10MST42.36900719
11STK392.32771332
12GRK12.29892674
13TLK12.22969863
14MUSK2.21037598
15WNK42.19399414
16MST1R2.16272457
17WNK32.02855288
18OXSR12.00503819
19ZAK1.88870765
20NUAK11.82142174
21FER1.77829371
22LMTK21.72012722
23MET1.56461132
24MAP4K21.51555165
25MAP3K121.46036037
26PRKCI1.41124209
27STK38L1.35242770
28EPHA31.20045787
29IRAK11.19204093
30DAPK21.13947526
31MAP2K61.12269900
32TXK1.08815944
33TRIM281.03726280
34BCKDK1.01541531
35NEK60.98965454
36CDK80.94169168
37MAP2K20.93332342
38MAPK150.91953918
39CASK0.91912094
40INSRR0.91730457
41MAPK130.90436982
42TGFBR10.89650177
43GRK60.89011426
44BRSK20.88883322
45PRKCE0.87498658
46ERBB30.86711502
47LATS10.84996468
48BCR0.84489388
49PRKAA20.83425963
50MAP2K10.82982295
51ADRBK10.82365836
52RPS6KB20.80911486
53EIF2AK30.80780810
54MAP3K40.79730179
55PDK20.72501973
56PRKG20.72094833
57LIMK10.71746554
58CHUK0.69641503
59PTK2B0.69508527
60CAMK2D0.66864073
61MAPKAPK50.66771997
62TESK20.66048763
63STK30.64343334
64ERBB20.62892606
65IKBKB0.57358812
66EIF2AK10.56347479
67FGFR20.55738262
68TNIK0.54702967
69TIE10.54124535
70CSNK1A10.52986074
71PHKG10.52114090
72PHKG20.52114090
73DYRK20.51416787
74PRKCA0.48888547
75PAK30.48668394
76IGF1R0.47201653
77MAP2K70.44657832
78PRKCZ0.44553060
79PRKCQ0.42587759
80NME10.40365005
81PRKACA0.37405619
82KIT0.35029243
83TESK10.33937658
84MAP3K90.33523286
85PRKAA10.31681108
86EPHB20.29823050
87MATK0.29771881
88CAMK2A0.29322509
89ABL20.28393828
90RPS6KA50.27758556
91PTK60.26131545
92PRKACG0.25276524
93PLK10.24685691
94SCYL20.24187798
95MAP2K40.23986824
96CSNK1D0.23332951
97PRKCG0.23324120
98CSNK1E0.23211469
99PRKG10.22081129
100CSNK1G30.20887837

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.84712515
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.08339754
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.92668286
4Linoleic acid metabolism_Homo sapiens_hsa005912.74996965
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.71091564
6Chemical carcinogenesis_Homo sapiens_hsa052042.60286252
7Fat digestion and absorption_Homo sapiens_hsa049752.51771646
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.41055101
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.39580719
10Retinol metabolism_Homo sapiens_hsa008302.39536129
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39302939
12Sulfur metabolism_Homo sapiens_hsa009202.37697120
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.26463575
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.20974951
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.20861863
16Nitrogen metabolism_Homo sapiens_hsa009102.19301017
17Butanoate metabolism_Homo sapiens_hsa006502.07139874
18Tryptophan metabolism_Homo sapiens_hsa003802.04030521
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.96807917
20Histidine metabolism_Homo sapiens_hsa003401.90884476
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.90102330
22Vitamin digestion and absorption_Homo sapiens_hsa049771.86100412
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84896502
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81572066
25Arginine biosynthesis_Homo sapiens_hsa002201.75210947
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69023224
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68117821
28Arachidonic acid metabolism_Homo sapiens_hsa005901.62186319
29Fatty acid degradation_Homo sapiens_hsa000711.61871873
30Peroxisome_Homo sapiens_hsa041461.51397356
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.46517388
32Mineral absorption_Homo sapiens_hsa049781.42031202
33ABC transporters_Homo sapiens_hsa020101.38885009
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37275728
35Starch and sucrose metabolism_Homo sapiens_hsa005001.31701050
36Bile secretion_Homo sapiens_hsa049761.30905120
37Propanoate metabolism_Homo sapiens_hsa006401.29416615
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22314859
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19865893
40Ether lipid metabolism_Homo sapiens_hsa005651.15636771
41beta-Alanine metabolism_Homo sapiens_hsa004101.10242353
42Tyrosine metabolism_Homo sapiens_hsa003501.07997786
43PPAR signaling pathway_Homo sapiens_hsa033201.06941248
44Phototransduction_Homo sapiens_hsa047441.06429347
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03625151
46Glycerolipid metabolism_Homo sapiens_hsa005611.03211123
47Selenocompound metabolism_Homo sapiens_hsa004500.98965525
48Arginine and proline metabolism_Homo sapiens_hsa003300.98925175
49Pancreatic secretion_Homo sapiens_hsa049720.97331141
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96148284
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94451309
52Phenylalanine metabolism_Homo sapiens_hsa003600.94273338
53Sulfur relay system_Homo sapiens_hsa041220.91016771
54Glutathione metabolism_Homo sapiens_hsa004800.88092675
55Protein export_Homo sapiens_hsa030600.86420434
56Complement and coagulation cascades_Homo sapiens_hsa046100.85268170
57Oxidative phosphorylation_Homo sapiens_hsa001900.80796599
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80243403
59Ovarian steroidogenesis_Homo sapiens_hsa049130.80137401
60Sphingolipid metabolism_Homo sapiens_hsa006000.77294159
61Fatty acid elongation_Homo sapiens_hsa000620.74346320
62Metabolic pathways_Homo sapiens_hsa011000.73548222
63Renin-angiotensin system_Homo sapiens_hsa046140.72730146
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.69776340
65Collecting duct acid secretion_Homo sapiens_hsa049660.68658198
66Fatty acid metabolism_Homo sapiens_hsa012120.66916123
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63910871
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62836171
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59704322
70Protein digestion and absorption_Homo sapiens_hsa049740.59133618
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58370558
72Pyruvate metabolism_Homo sapiens_hsa006200.47755042
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39483060
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38908184
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37676042
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.36198103
77Circadian rhythm_Homo sapiens_hsa047100.35461641
78Steroid biosynthesis_Homo sapiens_hsa001000.34555804
79One carbon pool by folate_Homo sapiens_hsa006700.33425199
80Fatty acid biosynthesis_Homo sapiens_hsa000610.33330627
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.33319372
82Parkinsons disease_Homo sapiens_hsa050120.32134418
83Huntingtons disease_Homo sapiens_hsa050160.30496243
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30043454
85Folate biosynthesis_Homo sapiens_hsa007900.27017410
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26623000
87Basal transcription factors_Homo sapiens_hsa030220.25077701
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23945626
89Serotonergic synapse_Homo sapiens_hsa047260.22373016
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21629937
91Taste transduction_Homo sapiens_hsa047420.21586384
92Regulation of autophagy_Homo sapiens_hsa041400.21143780
93Fructose and mannose metabolism_Homo sapiens_hsa000510.19162936
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16048438
95Proteasome_Homo sapiens_hsa030500.14733308
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13200058
97Tight junction_Homo sapiens_hsa045300.11877677
98Galactose metabolism_Homo sapiens_hsa000520.10592006
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09664484
100Homologous recombination_Homo sapiens_hsa034400.09348371

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