C5AR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)7.69249683
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.69249683
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.69249683
4positive regulation by organism of defense response of other organism involved in symbiotic interact7.69249683
5modulation by symbiont of host immune response (GO:0052553)7.69249683
6positive regulation by symbiont of host defense response (GO:0052509)7.69249683
7neutrophil activation involved in immune response (GO:0002283)5.91378760
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.43641191
9negative regulation of cell killing (GO:0031342)5.43641191
10response to host immune response (GO:0052572)5.42577773
11response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.42577773
12macrophage activation involved in immune response (GO:0002281)5.38845075
13regulation of interferon-beta biosynthetic process (GO:0045357)5.30160746
14microglial cell activation (GO:0001774)4.97914340
15* response to peptidoglycan (GO:0032494)4.97390286
16positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.92968820
17response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.89919964
18response to host (GO:0075136)4.89919964
19response to host defenses (GO:0052200)4.89919964
20immunoglobulin mediated immune response (GO:0016064)4.61024791
21cellular extravasation (GO:0045123)4.54305090
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.49374033
23positive regulation of interferon-alpha production (GO:0032727)4.44354921
24detection of bacterium (GO:0016045)4.34194468
25respiratory burst (GO:0045730)4.34055702
26regulation of interferon-alpha production (GO:0032647)4.27719704
27production of molecular mediator involved in inflammatory response (GO:0002532)4.25863770
28regulation of B cell receptor signaling pathway (GO:0050855)4.24467960
29positive regulation of mast cell activation (GO:0033005)4.14490344
30macrophage activation (GO:0042116)4.07680353
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.06983913
32antigen processing and presentation of endogenous antigen (GO:0019883)4.03889629
33granulocyte activation (GO:0036230)3.99584124
34detection of biotic stimulus (GO:0009595)3.94545358
35myeloid cell activation involved in immune response (GO:0002275)3.93431539
36neutrophil activation (GO:0042119)3.93259462
37positive regulation of antigen processing and presentation (GO:0002579)3.85222544
38regulation of gamma-delta T cell activation (GO:0046643)3.84198793
39regulation of mast cell degranulation (GO:0043304)3.82265356
40lipopolysaccharide-mediated signaling pathway (GO:0031663)3.76754140
41positive regulation of mast cell degranulation (GO:0043306)3.71602498
42positive regulation of mast cell activation involved in immune response (GO:0033008)3.71602498
43regulation of mast cell activation (GO:0033003)3.71167518
44neutrophil mediated immunity (GO:0002446)3.71053363
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.67317071
46detection of molecule of bacterial origin (GO:0032490)3.67070503
47regulation of mononuclear cell migration (GO:0071675)3.63422658
48positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.63095583
49positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.62235014
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.61920867
51regulation of mast cell activation involved in immune response (GO:0033006)3.60393993
52negative regulation of interleukin-12 production (GO:0032695)3.59782744
53negative regulation of mast cell activation (GO:0033004)3.54350236
54negative regulation of interleukin-17 production (GO:0032700)3.54212455
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.51937300
56regulation of interleukin-8 biosynthetic process (GO:0045414)3.49916684
57leukocyte aggregation (GO:0070486)3.48358561
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.47119639
59response to muramyl dipeptide (GO:0032495)3.44951769
60lymphocyte chemotaxis (GO:0048247)3.44912924
61germinal center formation (GO:0002467)3.43087114
62negative regulation of leukocyte mediated immunity (GO:0002704)3.34143259
63positive regulation of cellular amide metabolic process (GO:0034250)3.33590918
64positive regulation of toll-like receptor signaling pathway (GO:0034123)3.30267877
65positive regulation of chemokine biosynthetic process (GO:0045080)3.30237200
66regulation of leukocyte degranulation (GO:0043300)3.30180298
67positive regulation of interferon-beta production (GO:0032728)3.29118483
68positive regulation of macrophage cytokine production (GO:0060907)3.27680815
69regulation of antigen processing and presentation (GO:0002577)3.27030848
70regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.26216088
71defense response to protozoan (GO:0042832)3.25311787
72positive regulation of lymphocyte migration (GO:2000403)3.25040034
73eosinophil chemotaxis (GO:0048245)3.24651429
74negative regulation of T cell mediated immunity (GO:0002710)3.22278291
75regulation of cholesterol storage (GO:0010885)3.22140506
76B cell mediated immunity (GO:0019724)3.21735470
77negative regulation of cytokine production involved in immune response (GO:0002719)3.21408110
78positive regulation of monocyte chemotaxis (GO:0090026)3.19725139
79hydrogen peroxide biosynthetic process (GO:0050665)3.19333100
80regulation of myeloid leukocyte mediated immunity (GO:0002886)3.19007153
81regulation of T-helper 2 cell differentiation (GO:0045628)3.18808727
82negative regulation of interleukin-1 production (GO:0032692)3.17713763
83positive regulation of leukocyte degranulation (GO:0043302)3.17660300
84* neutrophil chemotaxis (GO:0030593)3.16363320
85negative regulation of interleukin-1 beta production (GO:0032691)3.16282452
86negative regulation of erythrocyte differentiation (GO:0045647)3.15297600
87positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.14822899
88regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.14619619
89regulation of tolerance induction (GO:0002643)3.14508098
90I-kappaB phosphorylation (GO:0007252)3.14269898
91pinocytosis (GO:0006907)3.12817242
92leukocyte migration involved in inflammatory response (GO:0002523)3.11757162
93regulation of T cell tolerance induction (GO:0002664)3.11324665
94negative regulation of interleukin-6 production (GO:0032715)3.09721076
95superoxide anion generation (GO:0042554)3.08995561
96interferon-gamma-mediated signaling pathway (GO:0060333)3.08465827
97* neutrophil migration (GO:1990266)3.07146733
98leukocyte degranulation (GO:0043299)3.06941548
99positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.06571836
100detection of other organism (GO:0098543)3.02456115
101negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.02203315
102response to protozoan (GO:0001562)3.01380326
103regulation of gamma-delta T cell differentiation (GO:0045586)3.00328621
104regulation of regulated secretory pathway (GO:1903305)2.99516264
105regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.98906542
106type I interferon signaling pathway (GO:0060337)2.98461171
107cellular response to type I interferon (GO:0071357)2.98461171
108eosinophil migration (GO:0072677)2.97154511
109* granulocyte chemotaxis (GO:0071621)2.96713459
110regulation of macrophage cytokine production (GO:0010935)2.96615974
111response to type I interferon (GO:0034340)2.95699311
112myeloid leukocyte activation (GO:0002274)2.94021907
113positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.92144346
114response to interleukin-15 (GO:0070672)2.91358230
115detection of external biotic stimulus (GO:0098581)2.90285074
116leukotriene metabolic process (GO:0006691)2.90023718
117* granulocyte migration (GO:0097530)2.84973837
118regulation of lymphocyte migration (GO:2000401)2.84774689
119regulation of lymphocyte chemotaxis (GO:1901623)2.84678274
120Arp2/3 complex-mediated actin nucleation (GO:0034314)2.82779603
121tolerance induction (GO:0002507)2.82547445
122positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.79705840
123regulation of interleukin-17 production (GO:0032660)2.79426195
124negative regulation of toll-like receptor signaling pathway (GO:0034122)2.79014726
125regulation of macrophage chemotaxis (GO:0010758)2.78860267
126reactive oxygen species biosynthetic process (GO:1903409)2.78112530
127positive regulation of tumor necrosis factor production (GO:0032760)2.77355971
128regulation of monocyte chemotaxis (GO:0090025)2.76731258
129phagocytosis, engulfment (GO:0006911)2.76076571
130leukocyte mediated cytotoxicity (GO:0001909)2.75552398
131regulation of T-helper 1 cell differentiation (GO:0045625)2.75003030
132positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.74834451
133negative regulation of myeloid cell apoptotic process (GO:0033033)2.72836042
134myeloid leukocyte mediated immunity (GO:0002444)2.72398114
135positive regulation of gamma-delta T cell activation (GO:0046645)2.72215508
136T-helper 1 type immune response (GO:0042088)2.71380166

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.23097852
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.13498900
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.36451511
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.92084557
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.65843759
6* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.99179515
7* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.87627253
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.42682483
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.31555010
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.01591530
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.96317640
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.86688274
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84089656
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.74855250
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71075850
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.65244604
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.64065152
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50974350
19* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.47264192
20* SPI1_23547873_ChIP-Seq_NB4_Human2.25827874
21PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.17791258
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15852034
23SPI1_23127762_ChIP-Seq_K562_Human2.06708201
24STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99820886
25SCL_19346495_ChIP-Seq_HPC-7_Human1.96795031
26VDR_24787735_ChIP-Seq_THP-1_Human1.96536551
27* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94383909
28PU_27001747_Chip-Seq_BMDM_Mouse1.90118401
29VDR_24763502_ChIP-Seq_THP-1_Human1.83689341
30PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.82422579
31CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.79278017
32* RUNX1_22412390_ChIP-Seq_EML_Mouse1.76769888
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72606367
34RUNX_20019798_ChIP-Seq_JUKART_Human1.70695142
35CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.68552229
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61601291
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60413609
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.53405339
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51458980
40MYB_26560356_Chip-Seq_TH2_Human1.51191695
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51180780
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49679824
43MYC_22102868_ChIP-Seq_BL_Human1.49220333
44CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.48535831
45CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.47808892
46MAF_26560356_Chip-Seq_TH2_Human1.42930733
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41423562
48* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39720358
49VDR_21846776_ChIP-Seq_THP-1_Human1.36423111
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33839636
51MAF_26560356_Chip-Seq_TH1_Human1.33284268
52NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30520220
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27039602
54SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26885490
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25592646
56PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24452179
57EGR1_19032775_ChIP-ChIP_M12_Human1.22992554
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22673599
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17229607
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16157027
61VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12528809
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11480964
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09305530
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08899021
65* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08782513
66GATA3_26560356_Chip-Seq_TH2_Human1.08144561
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08085133
68MYB_26560356_Chip-Seq_TH1_Human1.07334425
69UTX_26944678_Chip-Seq_JUKART_Human1.05512685
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04923805
71BCL6_27268052_Chip-Seq_Bcells_Human1.04326979
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02262420
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00444109
74GATA3_27048872_Chip-Seq_THYMUS_Human0.99567034
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97610933
76BCOR_27268052_Chip-Seq_Bcells_Human0.97475050
77SPI1_20517297_ChIP-Seq_HL60_Human0.97175035
78* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96963852
79GATA2_19941826_ChIP-Seq_K562_Human0.93391554
80GATA1_19941826_ChIP-Seq_K562_Human0.92961401
81KDM2B_26808549_Chip-Seq_JURKAT_Human0.90788219
82IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90725133
83TCF7_22412390_ChIP-Seq_EML_Mouse0.90144024
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.89714382
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87494631
86KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87404084
87ELK3_25401928_ChIP-Seq_HUVEC_Human0.86994800
88CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85436004
89* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84558559
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83703971
91STAT1_20625510_ChIP-Seq_HELA_Human0.81739148
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79493804
93SOX2_20726797_ChIP-Seq_SW620_Human0.78543177
94* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77267717
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.77167780
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76311387
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.75122713
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74614691
99NCOR1_26117541_ChIP-Seq_K562_Human0.74477654
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.74421535
101SMAD_19615063_ChIP-ChIP_OVARY_Human0.73906324
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.73362192
103ESR1_21235772_ChIP-Seq_MCF-7_Human0.70813994
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69926206
105RARG_19884340_ChIP-ChIP_MEFs_Mouse0.69843299
106LXR_22292898_ChIP-Seq_THP-1_Human0.69053570
107NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68143047
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68143047
109* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68039931
110KDM2B_26808549_Chip-Seq_DND41_Human0.68032782
111TFEB_21752829_ChIP-Seq_HELA_Human0.67917299
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.67894170
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.67551295
114GATA1_22025678_ChIP-Seq_K562_Human0.65373166
115CJUN_26792858_Chip-Seq_BT549_Human0.65318541
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64876256
117* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64473429
118TRIM28_21343339_ChIP-Seq_HEK293_Human0.64348163

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.68605752
2MP0005058_abnormal_lysosome_morphology4.00885287
3MP0001835_abnormal_antigen_presentation3.79952013
4MP0003303_peritoneal_inflammation3.65366121
5MP0009785_altered_susceptibility_to3.51741624
6MP0002148_abnormal_hypersensitivity_rea3.46356187
7* MP0002419_abnormal_innate_immunity3.44228241
8MP0005000_abnormal_immune_tolerance3.17514201
9MP0006082_CNS_inflammation3.11083387
10MP0003724_increased_susceptibility_to3.03996344
11MP0009278_abnormal_bone_marrow2.84571230
12* MP0005025_abnormal_response_to2.74541381
13MP0001533_abnormal_skeleton_physiology2.65953823
14MP0003172_abnormal_lysosome_physiology2.64729633
15MP0003191_abnormal_cellular_cholesterol2.48874696
16MP0002452_abnormal_antigen_presenting2.47433509
17MP0000343_altered_response_to2.47071773
18MP0001790_abnormal_immune_system2.45749003
19MP0005387_immune_system_phenotype2.45749003
20MP0002723_abnormal_immune_serum2.26484756
21* MP0001800_abnormal_humoral_immune2.24781028
22MP0004510_myositis2.22864814
23MP0005464_abnormal_platelet_physiology2.13632944
24MP0009840_abnormal_foam_cell2.10991088
25MP0003075_altered_response_to2.02360001
26* MP0001819_abnormal_immune_cell2.01450626
27* MP0002420_abnormal_adaptive_immunity2.00637980
28MP0009764_decreased_sensitivity_to1.97731685
29MP0002405_respiratory_system_inflammati1.97400177
30MP0000685_abnormal_immune_system1.95691292
31MP0005671_abnormal_response_to1.90224881
32MP0005167_abnormal_blood-brain_barrier1.88646850
33MP0001853_heart_inflammation1.87399280
34MP0001845_abnormal_inflammatory_respons1.86226128
35MP0003448_altered_tumor_morphology1.84818767
36MP0003300_gastrointestinal_ulcer1.82426671
37MP0003690_abnormal_glial_cell1.82337137
38MP0000604_amyloidosis1.81878891
39MP0008469_abnormal_protein_level1.68223275
40MP0003828_pulmonary_edema1.66254161
41MP0004947_skin_inflammation1.66057921
42MP0005397_hematopoietic_system_phenotyp1.59651008
43MP0001545_abnormal_hematopoietic_system1.59651008
44MP0005451_abnormal_body_composition1.57695530
45MP0002132_abnormal_respiratory_system1.50554866
46MP0005310_abnormal_salivary_gland1.45432196
47MP0003183_abnormal_peptide_metabolism1.44689332
48MP0010155_abnormal_intestine_physiology1.44164012
49MP0005166_decreased_susceptibility_to1.41162962
50MP0002277_abnormal_respiratory_mucosa1.40416381
51MP0000858_altered_metastatic_potential1.39490244
52MP0009333_abnormal_splenocyte_physiolog1.38833901
53MP0000716_abnormal_immune_system1.37092042
54MP0008004_abnormal_stomach_pH1.34626407
55MP0002998_abnormal_bone_remodeling1.33529243
56MP0005390_skeleton_phenotype1.29701639
57MP0002933_joint_inflammation1.28445713
58MP0005164_abnormal_response_to1.26914794
59MP0005076_abnormal_cell_differentiation1.24096050
60MP0002398_abnormal_bone_marrow1.21640482
61MP0004883_abnormal_blood_vessel1.20392029
62* MP0000689_abnormal_spleen_morphology1.17579265
63MP0000569_abnormal_digit_pigmentation1.17517378
64MP0003763_abnormal_thymus_physiology1.16006923
65MP0003806_abnormal_nucleotide_metabolis1.11984298
66MP0002429_abnormal_blood_cell1.10857073
67MP0000465_gastrointestinal_hemorrhage1.06904380
68MP0001851_eye_inflammation1.06831344
69MP0002254_reproductive_system_inflammat1.01258063
70MP0003866_abnormal_defecation0.99294707
71MP0002722_abnormal_immune_system0.99213848
72MP0002006_tumorigenesis0.93052561
73MP0010307_abnormal_tumor_latency0.92009593
74MP0003566_abnormal_cell_adhesion0.91943472
75* MP0009763_increased_sensitivity_to0.91481883
76MP0003656_abnormal_erythrocyte_physiolo0.91390355
77MP0000249_abnormal_blood_vessel0.87704244
78MP0005174_abnormal_tail_pigmentation0.87202969
79MP0000703_abnormal_thymus_morphology0.85459197
80MP0005023_abnormal_wound_healing0.85343820
81MP0003195_calcinosis0.83874759
82MP0004782_abnormal_surfactant_physiolog0.82378654
83MP0004381_abnormal_hair_follicle0.82228049
84MP0009765_abnormal_xenobiotic_induced0.77517054
85MP0003453_abnormal_keratinocyte_physiol0.76801357
86MP0003279_aneurysm0.76619880
87MP0000920_abnormal_myelination0.75220229
88MP0008260_abnormal_autophagy0.75155060
89MP0003795_abnormal_bone_structure0.73749330
90MP0006054_spinal_hemorrhage0.70867123
91MP0002332_abnormal_exercise_endurance0.70784743
92MP0002166_altered_tumor_susceptibility0.70462595
93MP0004808_abnormal_hematopoietic_stem0.70399363
94MP0008438_abnormal_cutaneous_collagen0.66522544
95MP0005257_abnormal_intraocular_pressure0.66042396
96MP0003329_amyloid_beta_deposits0.65226227
97MP0002139_abnormal_hepatobiliary_system0.62346579
98MP0003045_fibrosis0.62262018
99MP0008874_decreased_physiological_sensi0.62046699
100MP0003091_abnormal_cell_migration0.61497464
101MP0000490_abnormal_crypts_of0.60650068
102MP0005165_increased_susceptibility_to0.58621361
103MP0005319_abnormal_enzyme/_coenzyme0.57580417
104MP0003186_abnormal_redox_activity0.57418457
105MP0002136_abnormal_kidney_physiology0.56652600
106MP0000767_abnormal_smooth_muscle0.55488067
107MP0008873_increased_physiological_sensi0.55311728
108MP0000609_abnormal_liver_physiology0.53098241
109MP0001663_abnormal_digestive_system0.52303637
110MP0001958_emphysema0.51769406
111MP0003950_abnormal_plasma_membrane0.51606333
112MP0001873_stomach_inflammation0.49803378
113MP0004130_abnormal_muscle_cell0.48833640
114MP0002396_abnormal_hematopoietic_system0.48813822
115MP0003221_abnormal_cardiomyocyte_apopto0.48477092
116MP0002693_abnormal_pancreas_physiology0.48347415
117MP0000371_diluted_coat_color0.48273098
118MP0001986_abnormal_taste_sensitivity0.47592627
119MP0000015_abnormal_ear_pigmentation0.46059315
120MP0002138_abnormal_hepatobiliary_system0.45449768

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.96422542
2Systemic lupus erythematosus (HP:0002725)7.22550185
3Recurrent bacterial skin infections (HP:0005406)6.69128603
4Eczematoid dermatitis (HP:0000976)6.32309850
5Recurrent gram-negative bacterial infections (HP:0005420)5.91812757
6Increased cerebral lipofuscin (HP:0011813)5.66056697
7Increased neuronal autofluorescent lipopigment (HP:0002074)5.41411508
8Vacuolated lymphocytes (HP:0001922)5.36385460
9Glomerulonephritis (HP:0000099)5.16982051
10Abnormality of macrophages (HP:0004311)5.13091372
11Stomatitis (HP:0010280)4.63569932
12Mediastinal lymphadenopathy (HP:0100721)4.31854579
13Dysostosis multiplex (HP:0000943)4.27636724
14Gingivitis (HP:0000230)4.08447807
15Myositis (HP:0100614)4.08258392
16Orchitis (HP:0100796)4.08011583
17Disinhibition (HP:0000734)4.04847494
18Obstructive lung disease (HP:0006536)3.95259302
19Chronic obstructive pulmonary disease (HP:0006510)3.95259302
20Abnormality of complement system (HP:0005339)3.89652444
21Axonal loss (HP:0003447)3.80536889
22Retrobulbar optic neuritis (HP:0100654)3.77654481
23Optic neuritis (HP:0100653)3.77654481
24Recurrent skin infections (HP:0001581)3.75514903
25Prostate neoplasm (HP:0100787)3.72024475
26Complement deficiency (HP:0004431)3.69220243
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.50185690
28Elevated erythrocyte sedimentation rate (HP:0003565)3.43467491
29Gastrointestinal infarctions (HP:0005244)3.39394443
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.37345813
31Thick nail (HP:0001805)3.33714778
32Mucopolysacchariduria (HP:0008155)3.30958872
33Urinary glycosaminoglycan excretion (HP:0003541)3.30958872
34Abnormality of liposaccharide metabolism (HP:0010968)3.26600440
35Abnormality of glycosphingolipid metabolism (HP:0004343)3.26600440
36Abnormality of glycolipid metabolism (HP:0010969)3.26600440
37Nephritis (HP:0000123)3.19001260
38Pustule (HP:0200039)3.18750242
39Spontaneous hematomas (HP:0007420)3.17260134
40Agnosia (HP:0010524)3.16642117
41Abnormality of mucopolysaccharide metabolism (HP:0011020)3.14725477
42Abnormality of polysaccharide metabolism (HP:0011012)3.14725477
43Abnormality of glycosaminoglycan metabolism (HP:0004371)3.14725477
44Hemoptysis (HP:0002105)3.06898995
45Urticaria (HP:0001025)3.02491169
46Recurrent fungal infections (HP:0002841)3.00637882
47Episodic fever (HP:0001954)2.98872330
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.95258221
49Increased IgE level (HP:0003212)2.89057886
50Basal ganglia calcification (HP:0002135)2.80333333
51Cellulitis (HP:0100658)2.74984021
52Hepatosplenomegaly (HP:0001433)2.71412659
53Periodontitis (HP:0000704)2.70282159
54Myocardial infarction (HP:0001658)2.68365268
55Autoimmune thrombocytopenia (HP:0001973)2.65466316
56Chest pain (HP:0100749)2.63779725
57Hematochezia (HP:0002573)2.62741204
58T lymphocytopenia (HP:0005403)2.60993335
59Increased serum ferritin (HP:0003281)2.60644666
60Prolonged bleeding time (HP:0003010)2.59786236
61Pulmonary embolism (HP:0002204)2.58577306
62Interstitial pulmonary disease (HP:0006530)2.58169309
63Recurrent viral infections (HP:0004429)2.57788194
64Upper motor neuron abnormality (HP:0002127)2.55920244
65Vasculitis (HP:0002633)2.50200070
66Abnormality of T cell number (HP:0011839)2.47743987
67Meningitis (HP:0001287)2.46441722
68Progressive visual loss (HP:0000529)2.46221132
69Pulmonary infiltrates (HP:0002113)2.45153173
70Gangrene (HP:0100758)2.43340002
71Hypochromic microcytic anemia (HP:0004840)2.42476335
72Loss of speech (HP:0002371)2.41446500
73Keratoconjunctivitis sicca (HP:0001097)2.34358390
74Osteomyelitis (HP:0002754)2.32386402
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.31629938
76Osteolytic defects of the hand bones (HP:0009699)2.31629938
77Increased IgM level (HP:0003496)2.31050208
78Polyneuropathy (HP:0001271)2.30425778
79Epistaxis (HP:0000421)2.30316858
80Hypochromic anemia (HP:0001931)2.29641188
81Peritonitis (HP:0002586)2.29530174
82Abnormality of the vasculature of the conjunctiva (HP:0008054)2.29005790
83Abnormality of iron homeostasis (HP:0011031)2.28145641
84Abnormality of the prostate (HP:0008775)2.27473604
85Pathologic fracture (HP:0002756)2.26711218
86Recurrent pneumonia (HP:0006532)2.23469116
87Abnormality of the pleura (HP:0002103)2.22801559
88Arterial thrombosis (HP:0004420)2.21087334
89Joint hemorrhage (HP:0005261)2.19583979
90Leukocytosis (HP:0001974)2.19449166
91Petechiae (HP:0000967)2.16704952
92Vertigo (HP:0002321)2.14162040
93J-shaped sella turcica (HP:0002680)2.11352143
94Mutism (HP:0002300)2.10184024
95Keratoconjunctivitis (HP:0001096)2.09837918
96Inappropriate behavior (HP:0000719)2.07822776
97Abnormality of the endocardium (HP:0004306)2.05183032
98Apathy (HP:0000741)2.04218834
99Diminished motivation (HP:0000745)2.04053778
100Colitis (HP:0002583)2.03582504
101Acne (HP:0001061)2.02758763
102Premature loss of primary teeth (HP:0006323)2.02360544
103Bone pain (HP:0002653)2.02344390
104Glomerulopathy (HP:0100820)2.02195305
105Chronic otitis media (HP:0000389)2.01195553
106Peripheral demyelination (HP:0011096)1.99865677
107Abnormality of T cells (HP:0002843)1.98063877
108Amyloidosis (HP:0011034)1.97987042
109Conjunctival telangiectasia (HP:0000524)1.97909292
110Inflammation of the large intestine (HP:0002037)1.95636096
111Hypergammaglobulinemia (HP:0010702)1.94901627
112Progressive neurologic deterioration (HP:0002344)1.92249199
113Neuronal loss in central nervous system (HP:0002529)1.90513573
114Chronic mucocutaneous candidiasis (HP:0002728)1.90115066
115Recurrent cutaneous fungal infections (HP:0011370)1.90115066
116Abnormality of the pericardium (HP:0001697)1.89642740
117Abnormality of the lumbar spine (HP:0100712)1.89310852
118Microcytic anemia (HP:0001935)1.88686162
119Keratitis (HP:0000491)1.88607498
120Abnormality of transition element cation homeostasis (HP:0011030)1.88227032
121Abnormality of the peritoneum (HP:0002585)1.88173727
122Thoracic kyphosis (HP:0002942)1.85028438
123Recurrent lower respiratory tract infections (HP:0002783)1.84614402
124Neoplasm of head and neck (HP:0012288)1.80831404
125Esophageal neoplasm (HP:0100751)1.80831404
126Asymmetric septal hypertrophy (HP:0001670)1.76984962
127Gastrointestinal inflammation (HP:0004386)1.76567180
128Personality changes (HP:0000751)1.76358627
129Sepsis (HP:0100806)1.73628611
130Gingival bleeding (HP:0000225)1.72325416
131Purpura (HP:0000979)1.71648945
132Anorexia (HP:0002039)1.71354429
133Vertebral compression fractures (HP:0002953)1.69557578
134Encephalitis (HP:0002383)1.69205376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.25431215
2IRAK44.14130808
3RIPK43.45822181
4TBK13.00591225
5MAP3K142.98363004
6TYK22.97018896
7IRAK32.92502594
8TGFBR22.90365709
9MAP4K12.78909628
10KIT2.51429782
11TXK2.39761808
12ERN12.35891893
13IKBKE2.06001067
14FGR1.96954968
15TNK21.96478773
16CSK1.95322937
17PRPF4B1.91535724
18IKBKB1.90082039
19GRK71.87944031
20EPHB11.81310948
21HCK1.77133009
22FES1.76697570
23STK101.65247156
24BTK1.64078665
25ZAP701.63574844
26CSF1R1.58565792
27TEC1.51824202
28JAK11.48828376
29MAP2K31.48124031
30LYN1.44088131
31SYK1.37077537
32JAK31.32303161
33CAMK1D1.26552061
34MAP3K31.26010128
35SIK31.25404691
36MATK1.21625620
37ITK1.18033929
38LCK1.11587424
39NEK91.10381938
40JAK21.02384768
41CAMKK20.97867476
42ACVR1B0.94906708
43TRPM70.94212468
44PIM20.92640262
45CHUK0.91424351
46MAP3K130.88850732
47MARK30.86156696
48MARK20.85625822
49DAPK20.85615051
50BMPR20.84718131
51TTN0.84649265
52PBK0.84228509
53RPS6KA40.83704002
54TAOK30.83166606
55CLK10.81103268
56ERBB30.80403344
57CDC42BPA0.80154626
58PIM10.79724457
59MAP3K110.79079004
60PAK40.77794456
61PDK10.77164899
62EGFR0.77060099
63MOS0.76519728
64PRKD20.76451579
65ADRBK20.74700466
66NME20.72552236
67CAMK1G0.71787097
68SIK20.71474490
69* PRKCD0.71372966
70ABL10.69691726
71LRRK20.66757813
72MAPK70.66142667
73MAP3K100.65994484
74KDR0.65942115
75EIF2AK20.64428210
76CAMKK10.63181759
77MAPK120.62953342
78TRIB30.57969631
79MAP2K60.57189738
80MAP3K20.56760958
81FYN0.56402379
82BMX0.56084869
83ABL20.55780991
84IRAK20.55370867
85MAP2K40.55165150
86PKN20.54113575
87PIK3CG0.53993114
88RPS6KC10.53081977
89RPS6KL10.53081977
90EPHA30.52557494
91GRK60.52205501
92PTK60.51520807
93MAP3K10.50975418
94MAP3K60.50713712
95MAP3K50.50401010
96SCYL20.49489262
97IRAK10.49425261
98YES10.48243150
99CDK60.48199241
100KSR20.47891059
101KSR10.47607598
102MAPKAPK20.46171982
103SGK30.46087024
104DYRK1B0.45494299
105STK110.44930843
106TAOK10.44426037
107IGF1R0.42685323
108PRKCQ0.42436514
109CDK190.42185187
110TESK20.40590760
111MAP3K120.39109262
112RIPK10.39018459
113DDR20.38996196
114TESK10.38642239
115DYRK30.37621560
116FGFR30.36830603
117PTK2B0.35729368
118MAPK40.34379623
119HIPK20.33981305
120TAOK20.33550657
121DMPK0.32574110
122MAP3K70.31263512
123PRKG20.30023242
124RAF10.29759441
125GSK3A0.29606868
126RPS6KA60.29070127
127RPS6KA10.28445947
128STK40.28296183
129RPS6KA20.28222137
130SGK20.27961161
131MST40.26050624
132MAP3K80.23692353
133PRKCH0.23215399
134PDPK10.23214524

Predicted pathways (KEGG)

RankGene SetZ-score
1* Staphylococcus aureus infection_Homo sapiens_hsa051504.53943480
2Leishmaniasis_Homo sapiens_hsa051403.51839414
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.84314643
4Pertussis_Homo sapiens_hsa051332.77477981
5Lysosome_Homo sapiens_hsa041422.73936377
6Osteoclast differentiation_Homo sapiens_hsa043802.71387715
7Legionellosis_Homo sapiens_hsa051342.55508262
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.50264730
9Tuberculosis_Homo sapiens_hsa051522.44471153
10Malaria_Homo sapiens_hsa051442.29125792
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.25828463
12Other glycan degradation_Homo sapiens_hsa005112.23685659
13Rheumatoid arthritis_Homo sapiens_hsa053232.18217042
14Phagosome_Homo sapiens_hsa041452.10999744
15Graft-versus-host disease_Homo sapiens_hsa053322.05736546
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01944829
17Salmonella infection_Homo sapiens_hsa051321.99155347
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84878121
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.75990454
20B cell receptor signaling pathway_Homo sapiens_hsa046621.75028098
21Asthma_Homo sapiens_hsa053101.67637863
22Measles_Homo sapiens_hsa051621.65448435
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60982530
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54625790
25TNF signaling pathway_Homo sapiens_hsa046681.53382878
26Hematopoietic cell lineage_Homo sapiens_hsa046401.52211262
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48980662
28Allograft rejection_Homo sapiens_hsa053301.47445905
29Chemokine signaling pathway_Homo sapiens_hsa040621.46489745
30Toxoplasmosis_Homo sapiens_hsa051451.46471532
31Shigellosis_Homo sapiens_hsa051311.42376543
32Influenza A_Homo sapiens_hsa051641.41900680
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41571089
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.38826068
35* Complement and coagulation cascades_Homo sapiens_hsa046101.33613348
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31827733
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17318933
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15819825
39Prion diseases_Homo sapiens_hsa050201.15370566
40Apoptosis_Homo sapiens_hsa042101.15027217
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.14165138
42Amoebiasis_Homo sapiens_hsa051461.11572679
43Antigen processing and presentation_Homo sapiens_hsa046121.08029019
44Herpes simplex infection_Homo sapiens_hsa051681.07104150
45Hepatitis B_Homo sapiens_hsa051611.04540838
46Type I diabetes mellitus_Homo sapiens_hsa049401.04062109
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.03426647
48African trypanosomiasis_Homo sapiens_hsa051430.97002471
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96787439
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94607091
51Viral myocarditis_Homo sapiens_hsa054160.94437857
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90899819
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88081360
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87906651
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86099875
56Hepatitis C_Homo sapiens_hsa051600.81816807
57Pancreatic cancer_Homo sapiens_hsa052120.76154486
58Caffeine metabolism_Homo sapiens_hsa002320.74773723
59Mineral absorption_Homo sapiens_hsa049780.70316624
60Non-small cell lung cancer_Homo sapiens_hsa052230.68686948
61Platelet activation_Homo sapiens_hsa046110.67793259
62Endocytosis_Homo sapiens_hsa041440.64968652
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.63128719
64Chronic myeloid leukemia_Homo sapiens_hsa052200.62836652
65Sphingolipid metabolism_Homo sapiens_hsa006000.62247784
66T cell receptor signaling pathway_Homo sapiens_hsa046600.60357018
67Autoimmune thyroid disease_Homo sapiens_hsa053200.60036169
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.59326626
69Acute myeloid leukemia_Homo sapiens_hsa052210.56000598
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54726867
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54106605
72Bladder cancer_Homo sapiens_hsa052190.52339264
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51130854
74GnRH signaling pathway_Homo sapiens_hsa049120.50234068
75FoxO signaling pathway_Homo sapiens_hsa040680.47055295
76Collecting duct acid secretion_Homo sapiens_hsa049660.42866334
77VEGF signaling pathway_Homo sapiens_hsa043700.41330546
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.40096776
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39798564
80Proteoglycans in cancer_Homo sapiens_hsa052050.39434674
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39176286
82Primary immunodeficiency_Homo sapiens_hsa053400.38960216
83HIF-1 signaling pathway_Homo sapiens_hsa040660.38521396
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35807819
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34044936
86Regulation of autophagy_Homo sapiens_hsa041400.33796031
87HTLV-I infection_Homo sapiens_hsa051660.33754761
88Prolactin signaling pathway_Homo sapiens_hsa049170.33619047
89Choline metabolism in cancer_Homo sapiens_hsa052310.33027484
90Type II diabetes mellitus_Homo sapiens_hsa049300.31240160
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30855113
92Epstein-Barr virus infection_Homo sapiens_hsa051690.30736970
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30561591
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29918175
95Renin-angiotensin system_Homo sapiens_hsa046140.29744373
96mTOR signaling pathway_Homo sapiens_hsa041500.28252172
97Dorso-ventral axis formation_Homo sapiens_hsa043200.27806837
98Endometrial cancer_Homo sapiens_hsa052130.27420374
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26971699
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26702468
101Renal cell carcinoma_Homo sapiens_hsa052110.26497869
102ABC transporters_Homo sapiens_hsa020100.26222737
103Notch signaling pathway_Homo sapiens_hsa043300.22971169
104Viral carcinogenesis_Homo sapiens_hsa052030.21969324
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21932239
106Small cell lung cancer_Homo sapiens_hsa052220.20838678
107Insulin resistance_Homo sapiens_hsa049310.17358149
108Rap1 signaling pathway_Homo sapiens_hsa040150.16908537
109Focal adhesion_Homo sapiens_hsa045100.16605114
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.16119160
111MAPK signaling pathway_Homo sapiens_hsa040100.15397184
112Systemic lupus erythematosus_Homo sapiens_hsa053220.14767597
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14487590
114Histidine metabolism_Homo sapiens_hsa003400.13065607

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