C5AR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.95176009
2behavioral response to nicotine (GO:0035095)4.92595855
3response to peptidoglycan (GO:0032494)4.68043756
4G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.63347015
5microglial cell activation (GO:0001774)4.46646427
6neutrophil activation involved in immune response (GO:0002283)4.29750817
7fucose catabolic process (GO:0019317)4.29555638
8L-fucose metabolic process (GO:0042354)4.29555638
9L-fucose catabolic process (GO:0042355)4.29555638
10superoxide anion generation (GO:0042554)4.16771757
11regulation of B cell receptor signaling pathway (GO:0050855)4.14802014
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.01025706
13negative regulation of cell killing (GO:0031342)4.01025706
14positive regulation by symbiont of host defense response (GO:0052509)3.84470079
15modulation by symbiont of host defense response (GO:0052031)3.84470079
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84470079
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84470079
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.84470079
19modulation by symbiont of host immune response (GO:0052553)3.84470079
20positive regulation of cellular amide metabolic process (GO:0034250)3.83626894
21negative regulation of mast cell activation (GO:0033004)3.73212907
22positive regulation of monocyte chemotaxis (GO:0090026)3.68096005
23DNA deamination (GO:0045006)3.66290821
24negative regulation of interleukin-1 production (GO:0032692)3.64535034
25purinergic nucleotide receptor signaling pathway (GO:0035590)3.63583564
26dendritic cell chemotaxis (GO:0002407)3.60622750
27positive regulation of antigen processing and presentation (GO:0002579)3.51953586
28neutrophil activation (GO:0042119)3.49658981
29facial nerve structural organization (GO:0021612)3.48791591
30dendritic cell migration (GO:0036336)3.44451313
31indole-containing compound catabolic process (GO:0042436)3.38164264
32indolalkylamine catabolic process (GO:0046218)3.38164264
33tryptophan catabolic process (GO:0006569)3.38164264
34positive regulation of gamma-delta T cell activation (GO:0046645)3.37465436
35negative regulation of interleukin-1 beta production (GO:0032691)3.36497575
36activated T cell proliferation (GO:0050798)3.36176675
37regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.35480476
38positive regulation of T cell mediated cytotoxicity (GO:0001916)3.33773072
39macrophage activation involved in immune response (GO:0002281)3.31429809
40oligosaccharide catabolic process (GO:0009313)3.29685137
41cellular response to interleukin-15 (GO:0071350)3.29643431
42indolalkylamine metabolic process (GO:0006586)3.28527048
43lipoxygenase pathway (GO:0019372)3.27987892
44detection of other organism (GO:0098543)3.26874712
45omega-hydroxylase P450 pathway (GO:0097267)3.24879764
46regulation of T cell mediated cytotoxicity (GO:0001914)3.21021978
47production of molecular mediator involved in inflammatory response (GO:0002532)3.19845976
48regulation of mast cell activation (GO:0033003)3.19816535
49macrophage activation (GO:0042116)3.19736009
50granulocyte activation (GO:0036230)3.18681955
51respiratory burst (GO:0045730)3.18612223
52response to host immune response (GO:0052572)3.14171457
53response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.14171457
54regulation of antigen processing and presentation (GO:0002577)3.13094055
55kynurenine metabolic process (GO:0070189)3.12625773
56cytidine deamination (GO:0009972)3.11741055
57cytidine metabolic process (GO:0046087)3.11741055
58cytidine catabolic process (GO:0006216)3.11741055
59mature B cell differentiation (GO:0002335)3.10923892
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07944550
61positive regulation of T cell migration (GO:2000406)3.07938793
62phagocytosis, engulfment (GO:0006911)3.07378454
63negative regulation of interleukin-12 production (GO:0032695)3.06985830
64antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.04080363
65regulation of interleukin-6 biosynthetic process (GO:0045408)3.00893161
66negative regulation of lymphocyte mediated immunity (GO:0002707)3.00316346
67response to interleukin-15 (GO:0070672)3.00222962
68adaptation of signaling pathway (GO:0023058)2.99765976
69negative regulation of granulocyte differentiation (GO:0030853)2.98608332
70regulation of memory T cell differentiation (GO:0043380)2.98366199
71regulation of dendritic cell antigen processing and presentation (GO:0002604)2.97103755
72regulation of mast cell degranulation (GO:0043304)2.96232426
73positive regulation of defense response to virus by host (GO:0002230)2.95994600
74antigen processing and presentation of endogenous antigen (GO:0019883)2.94431746
75tryptophan metabolic process (GO:0006568)2.92491992
76regulation of mast cell activation involved in immune response (GO:0033006)2.92479385
77regulation of interferon-beta biosynthetic process (GO:0045357)2.91029079
78regulation of activation of Janus kinase activity (GO:0010533)2.90282198
79glycosphingolipid catabolic process (GO:0046479)2.88493634
80amino sugar catabolic process (GO:0046348)2.87361826
81positive regulation of lymphocyte migration (GO:2000403)2.87232955
82cellular response to thyroid hormone stimulus (GO:0097067)2.86449897
83positive regulation of interleukin-1 beta secretion (GO:0050718)2.85756534
84T-helper 1 type immune response (GO:0042088)2.85348704
85myeloid cell activation involved in immune response (GO:0002275)2.84192583
86pyrimidine ribonucleoside catabolic process (GO:0046133)2.83882431
87negative regulation of telomere maintenance (GO:0032205)2.83871808
88positive regulation of mast cell degranulation (GO:0043306)2.83638836
89positive regulation of mast cell activation involved in immune response (GO:0033008)2.83638836
90regulation of gamma-delta T cell activation (GO:0046643)2.82821309
91cellular extravasation (GO:0045123)2.81884297
92G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.81326019
93negative regulation of T cell mediated immunity (GO:0002710)2.77625024
94leukocyte migration involved in inflammatory response (GO:0002523)2.76756043
95regulation of monocyte chemotaxis (GO:0090025)2.73853725
96positive regulation of mast cell activation (GO:0033005)2.71246466
97mature B cell differentiation involved in immune response (GO:0002313)2.70007602
98NAD biosynthetic process (GO:0009435)2.69904010
99mast cell activation (GO:0045576)2.69871944
100cellular response to exogenous dsRNA (GO:0071360)2.69234611
101myeloid dendritic cell activation (GO:0001773)2.68643138
102immunoglobulin mediated immune response (GO:0016064)2.68531071
103positive regulation of smooth muscle cell migration (GO:0014911)2.68254955
104cranial nerve structural organization (GO:0021604)2.67022791
105positive regulation of chemokine secretion (GO:0090197)2.66870412
106purinergic receptor signaling pathway (GO:0035587)2.66686553
107regulation of T cell migration (GO:2000404)2.66421617
108rRNA catabolic process (GO:0016075)2.66006738
109positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.64532421
110neutrophil mediated immunity (GO:0002446)2.64355690
111interferon-gamma production (GO:0032609)2.64176051
112neural tube formation (GO:0001841)2.64055480
113response to host (GO:0075136)2.63627299
114response to host defenses (GO:0052200)2.63627299
115response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.63627299
116positive regulation of toll-like receptor signaling pathway (GO:0034123)2.63202395
117antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.62938434
118definitive hemopoiesis (GO:0060216)2.61952638
119positive regulation of interleukin-1 secretion (GO:0050716)2.61317671
120membrane invagination (GO:0010324)2.60517279
121myeloid leukocyte activation (GO:0002274)2.60137398
122response to interferon-beta (GO:0035456)2.59949357
123sulfation (GO:0051923)2.57750553
124tolerance induction (GO:0002507)2.56760452
125response to pheromone (GO:0019236)2.56360791
126response to muramyl dipeptide (GO:0032495)2.55939056
127detection of light stimulus involved in visual perception (GO:0050908)2.55400199
128detection of light stimulus involved in sensory perception (GO:0050962)2.55400199
129positive regulation of interferon-alpha production (GO:0032727)2.55316580
130ceramide catabolic process (GO:0046514)2.55052670
131detection of bacterium (GO:0016045)2.53426595
132positive regulation of T-helper 1 type immune response (GO:0002827)2.52684858
133phosphatidylinositol acyl-chain remodeling (GO:0036149)2.52527841
134detection of molecule of bacterial origin (GO:0032490)2.52375351
135regulation of gamma-delta T cell differentiation (GO:0045586)2.51803455
136negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.50967576
137leukocyte aggregation (GO:0070486)2.50632295
138regulation of leukocyte mediated cytotoxicity (GO:0001910)2.50576350
139glycolipid catabolic process (GO:0019377)2.50284591
140positive regulation of T cell chemotaxis (GO:0010820)2.49913197
141regulation of T cell chemotaxis (GO:0010819)2.49913197
142defense response to protozoan (GO:0042832)2.49061353
143pinocytosis (GO:0006907)2.48159379
144response to folic acid (GO:0051593)2.47795866
145lymphoid progenitor cell differentiation (GO:0002320)2.46543499
146amine catabolic process (GO:0009310)2.45917781
147cellular biogenic amine catabolic process (GO:0042402)2.45917781
148positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.45677258
149mesenchymal cell differentiation involved in renal system development (GO:2001012)2.45208772
150mesenchymal cell differentiation involved in kidney development (GO:0072161)2.45208772
151daunorubicin metabolic process (GO:0044597)2.45017189
152polyketide metabolic process (GO:0030638)2.45017189
153doxorubicin metabolic process (GO:0044598)2.45017189
154regulation of interleukin-1 beta secretion (GO:0050706)2.44736856
155leukocyte degranulation (GO:0043299)2.43992659
156indole-containing compound metabolic process (GO:0042430)2.41790863
157detection of external biotic stimulus (GO:0098581)2.41734981
158negative regulation of cAMP-mediated signaling (GO:0043951)2.39562899
159negative regulation of leukocyte mediated immunity (GO:0002704)2.39016047
160killing of cells of other organism (GO:0031640)2.38550109
161disruption of cells of other organism (GO:0044364)2.38550109
162positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.37485944
163hydrogen peroxide biosynthetic process (GO:0050665)2.37212004
164regulation of regulatory T cell differentiation (GO:0045589)2.33999752
165negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.33629101

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.07547774
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.81767753
3ZNF274_21170338_ChIP-Seq_K562_Hela3.61260139
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.24534155
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88799310
6IRF8_27001747_Chip-Seq_BMDM_Mouse2.88618447
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.77421042
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66095437
9GBX2_23144817_ChIP-Seq_PC3_Human2.64371937
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.51590951
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.48071976
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47377264
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37239520
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37020737
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22970347
16SCL_19346495_ChIP-Seq_HPC-7_Human2.16495423
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08316359
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05379395
19SUZ12_27294783_Chip-Seq_NPCs_Mouse2.04663617
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.03312055
21NFE2_27457419_Chip-Seq_LIVER_Mouse1.99883370
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97077629
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.96676766
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95631534
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86175329
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81809334
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.78811563
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.77574246
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77466221
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74484199
31PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.72517403
32SUZ12_18555785_Chip-Seq_ESCs_Mouse1.69698778
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67897736
34EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.67759991
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67416185
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.66661922
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66417370
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64341647
39STAT3_18555785_Chip-Seq_ESCs_Mouse1.62650301
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60555005
41E2F1_18555785_Chip-Seq_ESCs_Mouse1.60250521
42EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.60070447
43P53_22387025_ChIP-Seq_ESCs_Mouse1.59110366
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58591858
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58006445
46GATA3_26560356_Chip-Seq_TH2_Human1.57596193
47NMYC_18555785_Chip-Seq_ESCs_Mouse1.57381689
48P300_18555785_Chip-Seq_ESCs_Mouse1.55891090
49RUNX1_27457419_Chip-Seq_LIVER_Mouse1.54910318
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.52012912
51TAF15_26573619_Chip-Seq_HEK293_Human1.50281075
52PU1_27457419_Chip-Seq_LIVER_Mouse1.49631049
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.48999091
54IGF1R_20145208_ChIP-Seq_DFB_Human1.48513589
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47752221
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46636680
57CMYC_18555785_Chip-Seq_ESCs_Mouse1.45305380
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44975266
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44955425
60TP53_22573176_ChIP-Seq_HFKS_Human1.44355492
61ZFX_18555785_Chip-Seq_ESCs_Mouse1.41988542
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39990109
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.39987666
64DROSHA_22980978_ChIP-Seq_HELA_Human1.39817030
65VDR_24787735_ChIP-Seq_THP-1_Human1.39583357
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.39288487
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38526697
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38240020
69BCAT_22108803_ChIP-Seq_LS180_Human1.35665098
70EZH2_22144423_ChIP-Seq_EOC_Human1.34702760
71SOX2_18555785_Chip-Seq_ESCs_Mouse1.34170530
72P300_19829295_ChIP-Seq_ESCs_Human1.33312373
73SPI1_23547873_ChIP-Seq_NB4_Human1.31837992
74RUNX_20019798_ChIP-Seq_JUKART_Human1.31390553
75ESRRB_18555785_Chip-Seq_ESCs_Mouse1.30872025
76CTCF_18555785_Chip-Seq_ESCs_Mouse1.30418644
77KLF4_18555785_Chip-Seq_ESCs_Mouse1.30173394
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28090000
79SMAD1_18555785_Chip-Seq_ESCs_Mouse1.27527049
80ERA_21632823_ChIP-Seq_H3396_Human1.26588939
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26258969
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.26258969
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26096726
84REST_21632747_ChIP-Seq_MESCs_Mouse1.25828724
85VDR_22108803_ChIP-Seq_LS180_Human1.25681136
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.24979181
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.24571932
88EED_16625203_ChIP-ChIP_MESCs_Mouse1.24132342
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23935255
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22020821
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.21244363
92EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20512127
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19574537
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19397155
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18810746
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18169799
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18169799
98NANOG_20526341_ChIP-Seq_ESCs_Human1.17943824
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16683658
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.15887600
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15617783
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15381773
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.15347150
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14690751
105PU_27001747_Chip-Seq_BMDM_Mouse1.14297505
106PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13862803
107STAT3_23295773_ChIP-Seq_U87_Human1.13593003
108EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13212596
109ER_23166858_ChIP-Seq_MCF-7_Human1.13065082
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12078171
111SMRT_27268052_Chip-Seq_Bcells_Human1.11872820
112NCOR_22424771_ChIP-Seq_293T_Human1.11858693
113OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11722239
114EWS_26573619_Chip-Seq_HEK293_Human1.11614101
115GATA3_27048872_Chip-Seq_THYMUS_Human1.11590758
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10529220
117TAF2_19829295_ChIP-Seq_ESCs_Human1.10195975
118GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.10015720
119IRF1_19129219_ChIP-ChIP_H3396_Human1.09754283
120HOXB7_26014856_ChIP-Seq_BT474_Human1.09615330
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09515205
122OCT4_20526341_ChIP-Seq_ESCs_Human1.08829904
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08639532
124AR_20517297_ChIP-Seq_VCAP_Human1.08496543
125TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07775834
126RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07359095
127NANOG_19829295_ChIP-Seq_ESCs_Human1.07075461
128SOX2_19829295_ChIP-Seq_ESCs_Human1.07075461
129RNF2_27304074_Chip-Seq_NSC_Mouse1.06773698
130CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06268495
131MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05666373
132MYB_26560356_Chip-Seq_TH2_Human1.05355245
133AR_25329375_ChIP-Seq_VCAP_Human1.05275920
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04974927
135TCF4_23295773_ChIP-Seq_U87_Human1.04421254
136SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04265698
137LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02744212
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02164891
139BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01739360
140JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01388390
141FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00902487
142FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00282427
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00165888
144MYC_19829295_ChIP-Seq_ESCs_Human1.00134146
145SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99931529
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98965947
147RAC3_21632823_ChIP-Seq_H3396_Human0.98792528
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98114114
149HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96305104
150FOXH1_21741376_ChIP-Seq_ESCs_Human0.95883111
151ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95869482
152MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95207916
153SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94404009
154FOXH1_21741376_ChIP-Seq_EPCs_Human0.94364077
155CBP_20019798_ChIP-Seq_JUKART_Human0.94214286
156IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94214286
157IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94028067
158FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93592916
159RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92762413
160TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91918815
161FLI1_21867929_ChIP-Seq_TH2_Mouse0.91114607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.07937580
2MP0003136_yellow_coat_color3.68648116
3MP0003724_increased_susceptibility_to3.35791617
4MP0002148_abnormal_hypersensitivity_rea3.16983588
5MP0006292_abnormal_olfactory_placode2.99727260
6MP0000569_abnormal_digit_pigmentation2.92590560
7MP0001188_hyperpigmentation2.92359948
8MP0005671_abnormal_response_to2.83465734
9MP0003195_calcinosis2.77403612
10MP0003436_decreased_susceptibility_to2.62392868
11MP0002419_abnormal_innate_immunity2.62237707
12MP0009785_altered_susceptibility_to2.62195897
13MP0005409_darkened_coat_color2.61919908
14MP0000015_abnormal_ear_pigmentation2.57558081
15MP0004381_abnormal_hair_follicle2.39941646
16MP0005000_abnormal_immune_tolerance2.38356478
17MP0003646_muscle_fatigue2.36551114
18MP0002277_abnormal_respiratory_mucosa2.28610786
19MP0005174_abnormal_tail_pigmentation2.22531438
20MP0005025_abnormal_response_to2.14374302
21MP0002452_abnormal_antigen_presenting2.12226136
22MP0001800_abnormal_humoral_immune2.04291557
23MP0001986_abnormal_taste_sensitivity1.99796984
24MP0006082_CNS_inflammation1.96194702
25MP0002723_abnormal_immune_serum1.92084283
26MP0001790_abnormal_immune_system1.86979181
27MP0005387_immune_system_phenotype1.86979181
28MP0001968_abnormal_touch/_nociception1.86625818
29MP0005171_absent_coat_pigmentation1.82603136
30MP0001819_abnormal_immune_cell1.80907286
31MP0002420_abnormal_adaptive_immunity1.80417776
32MP0005075_abnormal_melanosome_morpholog1.80005051
33MP0002009_preneoplasia1.77286350
34MP0005464_abnormal_platelet_physiology1.73145735
35MP0000427_abnormal_hair_cycle1.69070836
36MP0008877_abnormal_DNA_methylation1.68165210
37MP0008872_abnormal_physiological_respon1.63422525
38MP0005551_abnormal_eye_electrophysiolog1.61125855
39MP0002653_abnormal_ependyma_morphology1.55495806
40MP0004043_abnormal_pH_regulation1.52698487
41MP0008260_abnormal_autophagy1.52496801
42MP0002095_abnormal_skin_pigmentation1.52134323
43MP0004782_abnormal_surfactant_physiolog1.48626333
44MP0003787_abnormal_imprinting1.46852033
45MP0000372_irregular_coat_pigmentation1.46648943
46MP0002132_abnormal_respiratory_system1.46567182
47MP0002405_respiratory_system_inflammati1.46249997
48MP0000465_gastrointestinal_hemorrhage1.44865215
49MP0000685_abnormal_immune_system1.44757872
50MP0004130_abnormal_muscle_cell1.44468484
51MP0009764_decreased_sensitivity_to1.43671768
52MP0000566_synostosis1.43621088
53MP0003011_delayed_dark_adaptation1.41373713
54MP0002102_abnormal_ear_morphology1.41066850
55MP0002928_abnormal_bile_duct1.39481210
56MP0001533_abnormal_skeleton_physiology1.39086849
57MP0001501_abnormal_sleep_pattern1.38511173
58MP0003878_abnormal_ear_physiology1.34573477
59MP0005377_hearing/vestibular/ear_phenot1.34573477
60MP0009333_abnormal_splenocyte_physiolog1.34060720
61MP0005310_abnormal_salivary_gland1.33328730
62MP0000343_altered_response_to1.33104510
63MP0004510_myositis1.32060095
64MP0005058_abnormal_lysosome_morphology1.32001946
65MP0009697_abnormal_copulation1.27126984
66MP0003191_abnormal_cellular_cholesterol1.25500041
67MP0008875_abnormal_xenobiotic_pharmacok1.25092782
68MP0002138_abnormal_hepatobiliary_system1.23670717
69MP0001853_heart_inflammation1.23394024
70MP0009745_abnormal_behavioral_response1.22026314
71MP0009379_abnormal_foot_pigmentation1.20548475
72MP0000716_abnormal_immune_system1.20136782
73MP0001845_abnormal_inflammatory_respons1.19351179
74MP0002837_dystrophic_cardiac_calcinosis1.18753945
75MP0002933_joint_inflammation1.17324409
76MP0002396_abnormal_hematopoietic_system1.14322680
77MP0003828_pulmonary_edema1.13362622
78MP0002638_abnormal_pupillary_reflex1.12929675
79MP0003763_abnormal_thymus_physiology1.12219627
80MP0010155_abnormal_intestine_physiology1.12088964
81MP0002998_abnormal_bone_remodeling1.10944106
82MP0008004_abnormal_stomach_pH1.10469256
83MP0002398_abnormal_bone_marrow1.07851110
84MP0005083_abnormal_biliary_tract1.06966791
85MP0009046_muscle_twitch1.06625640
86MP0003866_abnormal_defecation1.06595518
87MP0008469_abnormal_protein_level1.06313450
88MP0001485_abnormal_pinna_reflex1.05435719
89MP0002693_abnormal_pancreas_physiology1.05402653
90MP0002736_abnormal_nociception_after1.05348573
91MP0003690_abnormal_glial_cell1.04843830
92MP0003045_fibrosis1.03756139
93MP0005085_abnormal_gallbladder_physiolo1.02618157
94MP0000689_abnormal_spleen_morphology1.01729501
95MP0003303_peritoneal_inflammation1.01560619
96MP0004885_abnormal_endolymph0.99117189
97MP0001873_stomach_inflammation0.99026795
98MP0005253_abnormal_eye_physiology0.97778055
99MP0002429_abnormal_blood_cell0.92677845
100MP0003252_abnormal_bile_duct0.92505349
101MP0002166_altered_tumor_susceptibility0.91477447
102MP0000230_abnormal_systemic_arterial0.91449367
103MP0003806_abnormal_nucleotide_metabolis0.90725167
104MP0002735_abnormal_chemical_nociception0.90372642
105MP0002006_tumorigenesis0.90185205
106MP0005645_abnormal_hypothalamus_physiol0.89380159
107MP0005646_abnormal_pituitary_gland0.89272113
108MP0004147_increased_porphyrin_level0.88803807
109MP0000470_abnormal_stomach_morphology0.88783356
110MP0002733_abnormal_thermal_nociception0.88719471
111MP0000681_abnormal_thyroid_gland0.88410006
112MP0000490_abnormal_crypts_of0.87678939
113MP0005379_endocrine/exocrine_gland_phen0.87384826
114MP0001970_abnormal_pain_threshold0.86675923
115MP0005167_abnormal_blood-brain_barrier0.86643861
116MP0005410_abnormal_fertilization0.86404662
117MP0003183_abnormal_peptide_metabolism0.85461092
118MP0002722_abnormal_immune_system0.85406323
119MP0000858_altered_metastatic_potential0.85357986
120MP0002064_seizures0.84020405
121MP0003638_abnormal_response/metabolism_0.83977614
122MP0004742_abnormal_vestibular_system0.83584505
123MP0001486_abnormal_startle_reflex0.83117419
124MP0004883_abnormal_blood_vessel0.82197809
125MP0005389_reproductive_system_phenotype0.80411980
126MP0003075_altered_response_to0.79846552
127MP0005084_abnormal_gallbladder_morpholo0.79410550
128MP0002272_abnormal_nervous_system0.78960935
129MP0003279_aneurysm0.77658354
130MP0005390_skeleton_phenotype0.76828631
131MP0003172_abnormal_lysosome_physiology0.76281919
132MP0000767_abnormal_smooth_muscle0.75983115
133MP0005164_abnormal_response_to0.75911475
134MP0003941_abnormal_skin_development0.75748190
135MP0002876_abnormal_thyroid_physiology0.75213832
136MP0001186_pigmentation_phenotype0.73552733
137MP0001663_abnormal_digestive_system0.73340246
138MP0001851_eye_inflammation0.72898275
139MP0001919_abnormal_reproductive_system0.72783451
140MP0008058_abnormal_DNA_repair0.72479060
141MP0000920_abnormal_myelination0.69675044
142MP0004808_abnormal_hematopoietic_stem0.68890907
143MP0000026_abnormal_inner_ear0.64851467
144MP0004142_abnormal_muscle_tone0.62620781
145MP0003448_altered_tumor_morphology0.61904183

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.30421587
2Recurrent bacterial skin infections (HP:0005406)4.52643118
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.01888743
4Eczematoid dermatitis (HP:0000976)4.01097244
5Pancreatic cysts (HP:0001737)3.88686078
6Congenital stationary night blindness (HP:0007642)3.86431978
7Systemic lupus erythematosus (HP:0002725)3.75144102
8Chromsome breakage (HP:0040012)3.57348933
9Glomerulonephritis (HP:0000099)3.50980244
10Abnormality of secondary sexual hair (HP:0009888)3.45643108
11Abnormality of the axillary hair (HP:0100134)3.45643108
12Prostate neoplasm (HP:0100787)3.39008606
13Obstructive lung disease (HP:0006536)3.36196450
14Chronic obstructive pulmonary disease (HP:0006510)3.36196450
15Optic neuritis (HP:0100653)3.34778312
16Retrobulbar optic neuritis (HP:0100654)3.34778312
17Abnormality of midbrain morphology (HP:0002418)3.31378041
18Molar tooth sign on MRI (HP:0002419)3.31378041
19Recurrent skin infections (HP:0001581)3.25202367
20Pancreatic fibrosis (HP:0100732)3.22569350
21True hermaphroditism (HP:0010459)3.13340070
22Recurrent cutaneous fungal infections (HP:0011370)3.11643391
23Chronic mucocutaneous candidiasis (HP:0002728)3.11643391
24Myositis (HP:0100614)3.05888320
25Mediastinal lymphadenopathy (HP:0100721)3.03535307
26Type II lissencephaly (HP:0007260)3.02703941
27Attenuation of retinal blood vessels (HP:0007843)3.01285064
28Orchitis (HP:0100796)3.00052872
29Meningitis (HP:0001287)2.95790345
30Nephronophthisis (HP:0000090)2.91406890
31Clubbing of toes (HP:0100760)2.87509060
32Recurrent gram-negative bacterial infections (HP:0005420)2.86211381
33Abnormality of macrophages (HP:0004311)2.85485508
34Prolonged bleeding time (HP:0003010)2.84779916
35Vacuolated lymphocytes (HP:0001922)2.82125473
36Stomatitis (HP:0010280)2.81976575
37Abolished electroretinogram (ERG) (HP:0000550)2.77562575
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.76887040
39Abnormality of the renal cortex (HP:0011035)2.74381954
403-Methylglutaconic aciduria (HP:0003535)2.74168989
41Hyperventilation (HP:0002883)2.73531381
42Stomach cancer (HP:0012126)2.71289805
43Type I transferrin isoform profile (HP:0003642)2.69324280
44Dry hair (HP:0011359)2.68187927
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.66482994
46Progressive inability to walk (HP:0002505)2.65438236
47Patchy hypopigmentation of hair (HP:0011365)2.61820826
48Recurrent fungal infections (HP:0002841)2.61423429
49Hypochromic anemia (HP:0001931)2.58608814
50Hypochromic microcytic anemia (HP:0004840)2.58494231
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.56380594
52Abnormal rod and cone electroretinograms (HP:0008323)2.54890801
53Polydipsia (HP:0001959)2.53369351
54Abnormal drinking behavior (HP:0030082)2.53369351
55Gastrointestinal infarctions (HP:0005244)2.53216330
56Abnormality of the renal medulla (HP:0100957)2.53095368
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.53047666
58Decreased circulating renin level (HP:0003351)2.51985466
59Recurrent pneumonia (HP:0006532)2.51640830
60Abnormality of alanine metabolism (HP:0010916)2.49211614
61Hyperalaninemia (HP:0003348)2.49211614
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49211614
63Inability to walk (HP:0002540)2.48264619
64Reduced antithrombin III activity (HP:0001976)2.46957765
65Tubular atrophy (HP:0000092)2.46723205
66Agammaglobulinemia (HP:0004432)2.46380390
67Clumsiness (HP:0002312)2.46059820
68Petechiae (HP:0000967)2.45004643
69White forelock (HP:0002211)2.42009859
70Basal ganglia calcification (HP:0002135)2.41613085
71Nonprogressive disorder (HP:0003680)2.41579990
72Gingivitis (HP:0000230)2.40745253
73Joint hemorrhage (HP:0005261)2.40330387
74Decreased central vision (HP:0007663)2.40105613
75Abnormality of glycolipid metabolism (HP:0010969)2.39754972
76Abnormality of liposaccharide metabolism (HP:0010968)2.39754972
77Abnormality of glycosphingolipid metabolism (HP:0004343)2.39754972
78Duplicated collecting system (HP:0000081)2.34560158
79Chronic hepatic failure (HP:0100626)2.31849639
80Large for gestational age (HP:0001520)2.31334235
81Abnormality of the prostate (HP:0008775)2.30964299
82Hypothermia (HP:0002045)2.28537606
83Increased cerebral lipofuscin (HP:0011813)2.27669516
84Thick nail (HP:0001805)2.26009492
85Cystic liver disease (HP:0006706)2.24902724
86Genetic anticipation (HP:0003743)2.23404430
87Abnormality of the renal collecting system (HP:0004742)2.22193149
88Medial flaring of the eyebrow (HP:0010747)2.17781292
89Cerebellar dysplasia (HP:0007033)2.14136784
90Abnormal delayed hypersensitivity skin test (HP:0002963)2.13710978
91Congenital, generalized hypertrichosis (HP:0004540)2.13291953
92Recurrent lower respiratory tract infections (HP:0002783)2.11950414
93Protruding tongue (HP:0010808)2.11487292
94Aplasia cutis congenita (HP:0001057)2.09787473
95Encephalitis (HP:0002383)2.08585160
96Epistaxis (HP:0000421)2.07238271
97Chronic diarrhea (HP:0002028)2.06898721
98Progressive cerebellar ataxia (HP:0002073)2.06108379
99Cheilitis (HP:0100825)2.05153451
100Keratoconjunctivitis sicca (HP:0001097)2.04718730
101Concave nail (HP:0001598)2.04451907
102Purpura (HP:0000979)2.03992816
103Pendular nystagmus (HP:0012043)2.03870794
104Anhidrosis (HP:0000970)2.03012270
105Furrowed tongue (HP:0000221)2.02661233
106Aplasia/Hypoplasia of the uvula (HP:0010293)2.02329326
107Bony spicule pigmentary retinopathy (HP:0007737)2.01926437
108Meckel diverticulum (HP:0002245)2.01512285
109Vasculitis (HP:0002633)1.99391123
110Abnormality of the preputium (HP:0100587)1.99182698
111Episodic fever (HP:0001954)1.98101254
112Anorexia (HP:0002039)1.97364921
113Osteomyelitis (HP:0002754)1.97059925
114Panhypogammaglobulinemia (HP:0003139)1.96566102
115Hypergonadotropic hypogonadism (HP:0000815)1.94722454
116Abnormality of incisor morphology (HP:0011063)1.94459099
117Submucous cleft hard palate (HP:0000176)1.94328270
118Abnormality of T cell number (HP:0011839)1.94317518
119Polyuria (HP:0000103)1.94256725
120Lissencephaly (HP:0001339)1.93266406
121Agitation (HP:0000713)1.92475787
122Parakeratosis (HP:0001036)1.91628048
123Abnormality of chromosome stability (HP:0003220)1.91432291
124Constricted visual fields (HP:0001133)1.91065057
125Increased IgM level (HP:0003496)1.90189202
126Abnormality of the pons (HP:0007361)1.89803810
127Periodontitis (HP:0000704)1.89291516
128Nephritis (HP:0000123)1.88940289
129Abnormality of the ileum (HP:0001549)1.88754306
130Agnosia (HP:0010524)1.87940060
131Severe muscular hypotonia (HP:0006829)1.87723355
132Abnormal biliary tract physiology (HP:0012439)1.87022826
133Bile duct proliferation (HP:0001408)1.87022826
134Keratoconjunctivitis (HP:0001096)1.87004248
135Inflammation of the large intestine (HP:0002037)1.85924666
136Gaze-evoked nystagmus (HP:0000640)1.84630406
137Hypoplasia of the pons (HP:0012110)1.84545846
138Congenital hepatic fibrosis (HP:0002612)1.84213981
139Abnormality of T cells (HP:0002843)1.84036146
140Abnormality of transition element cation homeostasis (HP:0011030)1.83280302
141Glomerulopathy (HP:0100820)1.82267175
142IgG deficiency (HP:0004315)1.81649220
143Pulmonary infiltrates (HP:0002113)1.81494533
144Congenital sensorineural hearing impairment (HP:0008527)1.79356054
145Elevated erythrocyte sedimentation rate (HP:0003565)1.78539901
146Increased corneal curvature (HP:0100692)1.78073016
147Keratoconus (HP:0000563)1.78073016
148Spontaneous hematomas (HP:0007420)1.77540099
149Thyroiditis (HP:0100646)1.76016142
150Febrile seizures (HP:0002373)1.73822987
151Hemoptysis (HP:0002105)1.73276242
152Septo-optic dysplasia (HP:0100842)1.73087715
153Chorioretinal atrophy (HP:0000533)1.72628726
154Abnormality of T cell physiology (HP:0011840)1.72122684
155T lymphocytopenia (HP:0005403)1.72025909
156Leukocytosis (HP:0001974)1.72000180
157Abnormality of eosinophils (HP:0001879)1.70851529
158Hepatosplenomegaly (HP:0001433)1.70625377
159Eosinophilia (HP:0001880)1.70545175
160Dynein arm defect of respiratory motile cilia (HP:0012255)1.70081022
161Absent/shortened dynein arms (HP:0200106)1.70081022
162Gingival bleeding (HP:0000225)1.69980418
163Pustule (HP:0200039)1.69671655
164Conical tooth (HP:0000698)1.69488670
165Cellulitis (HP:0100658)1.69401463
166Duplication of thumb phalanx (HP:0009942)1.68833900
167Aplasia/Hypoplasia of the fovea (HP:0008060)1.68809540
168Ectopic kidney (HP:0000086)1.68657312
169Fair hair (HP:0002286)1.68502376
170Abnormal glycosylation (HP:0012345)1.68315136
171Abnormal protein N-linked glycosylation (HP:0012347)1.68315136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.10287870
2CASK3.45784558
3IRAK33.37636433
4BLK3.35783729
5IRAK43.32641267
6ACVR1B2.95247653
7TXK2.80216273
8TGFBR22.73644441
9MUSK2.61699683
10MAP3K142.57986242
11TLK12.50040779
12GRK72.46030562
13CLK12.26796341
14MKNK22.16684713
15ZAK2.06408056
16DAPK21.93890979
17TNIK1.88410356
18EIF2AK21.83558600
19TEC1.80450008
20WNK41.78021304
21GRK61.73188373
22ADRBK21.72593583
23BMPR1B1.67069898
24OXSR11.59835975
25YES11.59501078
26IKBKB1.53702427
27NEK61.52779266
28MKNK11.51738383
29SRPK11.50560584
30NEK91.47547030
31NME21.45073348
32STK161.43809079
33MAP4K21.38685354
34WNK31.38514560
35GRK11.37958192
36RIPK41.36811739
37VRK11.32919032
38BMPR21.31193798
39ADRBK11.31115162
40IKBKE1.30868965
41MAP4K11.28499173
42KIT1.27861531
43PTK2B1.24146074
44PRPF4B1.22212625
45BTK1.19613687
46LYN1.18200052
47MAP3K111.16968167
48TYK21.16418853
49TNK21.15104287
50TIE11.12707184
51IRAK11.11121731
52INSRR1.09551345
53FES1.09147930
54STK111.08050108
55MST41.04836791
56IRAK21.00784096
57MAP2K61.00325967
58NLK0.97631801
59PKN10.95859670
60MAP2K30.94026904
61MARK30.92243947
62SIK20.91323253
63CSK0.89863536
64JAK10.88542986
65MAP3K120.87323860
66CDK80.85111379
67MAPK150.83723771
68SYK0.83409842
69PIM10.83041544
70CSF1R0.81024614
71SGK20.79977617
72CDK30.79838733
73HCK0.77081635
74MAP2K70.77063604
75TRPM70.75274638
76MAPK130.74649110
77EPHA30.73840333
78PIM20.73823278
79KDR0.73739647
80TGFBR10.72402472
81MAP2K40.71542321
82PAK30.70441662
83LCK0.69950691
84RPS6KA50.69790944
85NUAK10.69557945
86PIK3CG0.68053004
87MATK0.67742743
88MAPK120.66945802
89TAOK30.66115152
90CAMKK10.64655285
91PRKD20.64433769
92MAP2K20.64243145
93MAP3K70.62755261
94PRKAA20.62688799
95STK390.61861785
96TBK10.61518715
97ZAP700.59989499
98CHUK0.59555091
99FGR0.58911622
100JAK30.58328943
101MAPK70.57484506
102PRKCG0.57447954
103PINK10.55016267
104PRKCH0.54981660
105MAPKAPK30.53638425
106CAMK10.53494908
107CAMK1D0.52742322
108PDK10.51693867
109PRKCZ0.51692312
110TAOK10.50579680
111CDK190.50461288
112EPHB10.49462878
113PDK20.47840234
114DYRK20.47553547
115CDK90.46749936
116PIK3CA0.46390263
117WNK10.44364924
118SIK30.43520564
119JAK20.42806729
120PRKCD0.42013130
121MAP3K40.41767683
122CAMK40.41001093
123ERN10.40843427
124PTK60.38617761
125GRK50.38580382
126RPS6KA60.38330803
127RPS6KC10.38068124
128RPS6KL10.38068124
129MAPKAPK50.37938556
130MOS0.37925714
131MAP2K10.36634384
132PRKCQ0.36607591
133STK40.36596790
134MAPK40.36286742
135PRKG20.34131427
136SGK30.33040719
137HIPK20.32307024
138CAMKK20.31619481
139PRKCE0.29042369
140ITK0.28524134
141AKT30.28522961
142STK100.27005806

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.04694111
2Other glycan degradation_Homo sapiens_hsa005112.72481061
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.32019356
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.27310970
5Linoleic acid metabolism_Homo sapiens_hsa005912.25288881
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23385107
7Nitrogen metabolism_Homo sapiens_hsa009102.22035476
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.20124096
9Leishmaniasis_Homo sapiens_hsa051402.13298510
10Graft-versus-host disease_Homo sapiens_hsa053322.08059334
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.05261070
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02547508
13Allograft rejection_Homo sapiens_hsa053301.99988842
14Systemic lupus erythematosus_Homo sapiens_hsa053221.96943076
15Hematopoietic cell lineage_Homo sapiens_hsa046401.83174704
16Fanconi anemia pathway_Homo sapiens_hsa034601.82748638
17Measles_Homo sapiens_hsa051621.82330921
18Malaria_Homo sapiens_hsa051441.81118639
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.78703912
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70861185
21Arachidonic acid metabolism_Homo sapiens_hsa005901.69179468
22Osteoclast differentiation_Homo sapiens_hsa043801.67360905
23Pertussis_Homo sapiens_hsa051331.64525862
24Asthma_Homo sapiens_hsa053101.63233514
25Primary immunodeficiency_Homo sapiens_hsa053401.59697383
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59103943
27Autoimmune thyroid disease_Homo sapiens_hsa053201.57517939
28Rheumatoid arthritis_Homo sapiens_hsa053231.53327808
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49581784
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48380945
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.46615326
32Sphingolipid metabolism_Homo sapiens_hsa006001.42742260
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42228386
34Homologous recombination_Homo sapiens_hsa034401.38610832
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37418531
36Tuberculosis_Homo sapiens_hsa051521.31418595
37Selenocompound metabolism_Homo sapiens_hsa004501.30004868
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29199562
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.28478366
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26232190
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.24098528
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23216398
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21329314
44Nicotine addiction_Homo sapiens_hsa050331.19375998
45Lysosome_Homo sapiens_hsa041421.18029389
46Herpes simplex infection_Homo sapiens_hsa051681.16622945
47Olfactory transduction_Homo sapiens_hsa047401.16607993
48Tryptophan metabolism_Homo sapiens_hsa003801.13757004
49Ether lipid metabolism_Homo sapiens_hsa005651.13634037
50B cell receptor signaling pathway_Homo sapiens_hsa046621.11654572
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08462854
52Protein export_Homo sapiens_hsa030601.06072526
53Phagosome_Homo sapiens_hsa041451.05969232
54Caffeine metabolism_Homo sapiens_hsa002321.02957728
55Non-homologous end-joining_Homo sapiens_hsa034501.02393882
56African trypanosomiasis_Homo sapiens_hsa051431.01785515
57Chemokine signaling pathway_Homo sapiens_hsa040621.01203478
58Butanoate metabolism_Homo sapiens_hsa006501.00927702
59Salmonella infection_Homo sapiens_hsa051320.97339250
60Legionellosis_Homo sapiens_hsa051340.96657991
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93813091
62Dorso-ventral axis formation_Homo sapiens_hsa043200.93675604
63Influenza A_Homo sapiens_hsa051640.93398968
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92418505
65Collecting duct acid secretion_Homo sapiens_hsa049660.89051091
66Ribosome_Homo sapiens_hsa030100.88425433
67Antigen processing and presentation_Homo sapiens_hsa046120.86859785
68Toxoplasmosis_Homo sapiens_hsa051450.86198802
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85124773
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84574763
71Basal transcription factors_Homo sapiens_hsa030220.83867966
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83840392
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81505803
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81059939
75Glycerolipid metabolism_Homo sapiens_hsa005610.79431755
76Complement and coagulation cascades_Homo sapiens_hsa046100.77554531
77Circadian entrainment_Homo sapiens_hsa047130.76575077
78Phototransduction_Homo sapiens_hsa047440.76388703
79Apoptosis_Homo sapiens_hsa042100.75389179
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73120678
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72863224
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.72234434
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72142813
84TNF signaling pathway_Homo sapiens_hsa046680.71731377
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62397892
86Oxidative phosphorylation_Homo sapiens_hsa001900.62146934
87Type I diabetes mellitus_Homo sapiens_hsa049400.61401038
88Chemical carcinogenesis_Homo sapiens_hsa052040.60727410
89Hepatitis C_Homo sapiens_hsa051600.59403435
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.58804431
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58511831
92GABAergic synapse_Homo sapiens_hsa047270.58329790
93Calcium signaling pathway_Homo sapiens_hsa040200.58169845
94RNA polymerase_Homo sapiens_hsa030200.57552246
95Glutamatergic synapse_Homo sapiens_hsa047240.57144623
96Alcoholism_Homo sapiens_hsa050340.56767846
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.56692101
98Platelet activation_Homo sapiens_hsa046110.55864102
99Retinol metabolism_Homo sapiens_hsa008300.55730033
100Salivary secretion_Homo sapiens_hsa049700.55229000
101Histidine metabolism_Homo sapiens_hsa003400.54041284
102Insulin secretion_Homo sapiens_hsa049110.53877695
103Hepatitis B_Homo sapiens_hsa051610.53656545
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52984704
105ABC transporters_Homo sapiens_hsa020100.52785999
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51202717
107Long-term depression_Homo sapiens_hsa047300.50447353
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.50312646
109Taste transduction_Homo sapiens_hsa047420.50174403
110Cholinergic synapse_Homo sapiens_hsa047250.49468062
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49371236
112Peroxisome_Homo sapiens_hsa041460.49285036
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.48762448
114Vitamin digestion and absorption_Homo sapiens_hsa049770.48505135
115Serotonergic synapse_Homo sapiens_hsa047260.47262816
116Purine metabolism_Homo sapiens_hsa002300.46300338
117Pyrimidine metabolism_Homo sapiens_hsa002400.45795436
118T cell receptor signaling pathway_Homo sapiens_hsa046600.44654030
119Mineral absorption_Homo sapiens_hsa049780.42696982
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42543094
121MAPK signaling pathway_Homo sapiens_hsa040100.40457354
122Type II diabetes mellitus_Homo sapiens_hsa049300.40411248
123Base excision repair_Homo sapiens_hsa034100.38474140
124cAMP signaling pathway_Homo sapiens_hsa040240.37953601
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36867226
126DNA replication_Homo sapiens_hsa030300.36796244
127Shigellosis_Homo sapiens_hsa051310.36546264
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35499991
129Ovarian steroidogenesis_Homo sapiens_hsa049130.34392357
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33991510
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32198233
132Viral carcinogenesis_Homo sapiens_hsa052030.31700731
133Regulation of autophagy_Homo sapiens_hsa041400.30558653
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29809588
135Acute myeloid leukemia_Homo sapiens_hsa052210.29347630
136Morphine addiction_Homo sapiens_hsa050320.28348913
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27207558
138Nucleotide excision repair_Homo sapiens_hsa034200.26304987

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