ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	COPI coating of Golgi vesicle (GO:0048205)	5.09608653
2	Golgi transport vesicle coating (GO:0048200)	5.09608653
3	protein maturation by protein folding (GO:0022417)	3.83984526
4	cell adhesion mediated by integrin (GO:0033627)	3.76078817
5	axonemal dynein complex assembly (GO:0070286)	3.66354236
6	zinc ion transport (GO:0006829)	3.59463277
7	nucleotide transmembrane transport (GO:1901679)	3.53721115
8	keratan sulfate catabolic process (GO:0042340)	3.53635635
9	positive regulation of glycoprotein metabolic process (GO:1903020)	3.50876534
10	COPII vesicle coating (GO:0048208)	3.50295539
11	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.49822828
12	branched-chain amino acid catabolic process (GO:0009083)	3.44301815
13	zinc ion transmembrane transport (GO:0071577)	3.27945823
14	epithelial cilium movement (GO:0003351)	3.19581990
15	cellular zinc ion homeostasis (GO:0006882)	3.14186802
16	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.09093230
17	regulation of cilium movement (GO:0003352)	3.04547484
18	axoneme assembly (GO:0035082)	3.00810271
19	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.94245383
20	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.90707448
21	water-soluble vitamin biosynthetic process (GO:0042364)	2.85945876
22	signal peptide processing (GO:0006465)	2.85475740
23	cilium movement (GO:0003341)	2.85201936
24	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.83450201
25	regulation of metalloenzyme activity (GO:0048552)	2.76578783
26	daunorubicin metabolic process (GO:0044597)	2.76074992
27	polyketide metabolic process (GO:0030638)	2.76074992
28	doxorubicin metabolic process (GO:0044598)	2.76074992
29	protein retention in ER lumen (GO:0006621)	2.74112491
30	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.73291734
31	pteridine-containing compound biosynthetic process (GO:0042559)	2.73087842
32	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.72166729
33	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.71551913
34	L-phenylalanine metabolic process (GO:0006558)	2.71551913
35	nucleotide-sugar biosynthetic process (GO:0009226)	2.70633917
36	proteasome assembly (GO:0043248)	2.65615390
37	magnesium ion transport (GO:0015693)	2.63261571
38	aminoglycoside antibiotic metabolic process (GO:0030647)	2.63083538
39	glycoside metabolic process (GO:0016137)	2.62408472
40	establishment of integrated proviral latency (GO:0075713)	2.58769681
41	positive regulation of actin filament depolymerization (GO:0030836)	2.57051697
42	sequestering of metal ion (GO:0051238)	2.55820649
43	cullin deneddylation (GO:0010388)	2.55686342
44	ER to Golgi vesicle-mediated transport (GO:0006888)	2.54385891
45	cell redox homeostasis (GO:0045454)	2.53875174
46	AMP metabolic process (GO:0046033)	2.47241598
47	eosinophil chemotaxis (GO:0048245)	2.46729598
48	lipopolysaccharide biosynthetic process (GO:0009103)	2.45662927
49	establishment of viral latency (GO:0019043)	2.44360441
50	protein deneddylation (GO:0000338)	2.42404664
51	vesicle coating (GO:0006901)	2.41835785
52	protein N-linked glycosylation via asparagine (GO:0018279)	2.39965029
53	negative regulation of neurological system process (GO:0031645)	2.39337145
54	desmosome organization (GO:0002934)	2.38835397
55	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.37966869
56	L-phenylalanine catabolic process (GO:0006559)	2.37966869
57	membrane protein intracellular domain proteolysis (GO:0031293)	2.37957759
58	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.37668703
59	sphingomyelin metabolic process (GO:0006684)	2.37628481
60	peptidyl-asparagine modification (GO:0018196)	2.36973675
61	negative regulation of complement activation (GO:0045916)	2.36919212
62	4-hydroxyproline metabolic process (GO:0019471)	2.36383654
63	intraciliary transport (GO:0042073)	2.36369639
64	regulation of transforming growth factor beta1 production (GO:0032908)	2.36089088
65	cilium morphogenesis (GO:0060271)	2.35660516
66	sphingosine metabolic process (GO:0006670)	2.35615913
67	zinc ion homeostasis (GO:0055069)	2.35524497
68	regulation of integrin-mediated signaling pathway (GO:2001044)	2.35106133
69	protein N-linked glycosylation (GO:0006487)	2.35026590
70	protein carboxylation (GO:0018214)	2.34859111
71	peptidyl-glutamic acid carboxylation (GO:0017187)	2.34859111
72	vitamin biosynthetic process (GO:0009110)	2.32991734
73	nucleotide transport (GO:0006862)	2.32518844
74	fibrinolysis (GO:0042730)	2.30915565
75	negative regulation of protein activation cascade (GO:2000258)	2.30213076
76	C-terminal protein lipidation (GO:0006501)	2.29387723
77	nucleotide-sugar metabolic process (GO:0009225)	2.28178085
78	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	2.28160096
79	sequestering of extracellular ligand from receptor (GO:0035581)	2.27795693
80	retinol metabolic process (GO:0042572)	2.27602346
81	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.26355847
82	glutathione derivative metabolic process (GO:1901685)	2.26010071
83	glutathione derivative biosynthetic process (GO:1901687)	2.26010071
84	membrane budding (GO:0006900)	2.25301255
85	mitochondrial DNA replication (GO:0006264)	2.24444560
86	branched-chain amino acid metabolic process (GO:0009081)	2.23258284
87	S-adenosylmethionine metabolic process (GO:0046500)	2.22988544
88	retinal metabolic process (GO:0042574)	2.22355690
89	amyloid precursor protein catabolic process (GO:0042987)	2.21818191
90	amino acid salvage (GO:0043102)	2.21556662
91	L-methionine salvage (GO:0071267)	2.21556662
92	L-methionine biosynthetic process (GO:0071265)	2.21556662
93	regulation of cellular amino acid metabolic process (GO:0006521)	2.20808596
94	oligosaccharide catabolic process (GO:0009313)	2.18253391
95	sphingolipid catabolic process (GO:0030149)	2.15929259
96	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.15125381
97	xenobiotic catabolic process (GO:0042178)	2.15078381
98	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.14701626
99	eosinophil migration (GO:0072677)	2.14208281
100	membrane lipid catabolic process (GO:0046466)	2.13952071

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.60487910
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.19511808
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.71457459
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.70234069
5	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.65367303
6	ELK1_19687146_ChIP-ChIP_HELA_Human	2.52024094
7	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.29527550
8	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.23559326
9	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	2.22848656
10	AR_21909140_ChIP-Seq_LNCAP_Human	2.11601629
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.07371722
12	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.96572742
13	* HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.93821047
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.86965813
15	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.79921137
16	SOX2_20726797_ChIP-Seq_SW620_Human	1.79737193
17	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.78333416
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.72792652
19	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.69903244
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.69153644
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.64368735
22	CLOCK_20551151_ChIP-Seq_293T_Human	1.59457513
23	CJUN_26792858_Chip-Seq_BT549_Human	1.58129152
24	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.56572101
25	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.54963275
26	FUS_26573619_Chip-Seq_HEK293_Human	1.54432746
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.52779574
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51064656
29	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.50120089
30	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.49829774
31	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.49565677
32	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.47140310
33	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.46929773
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.45886480
35	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.45600449
36	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.44263362
37	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.43541195
38	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.43078256
39	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.40872375
40	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.40872375
41	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.40736983
42	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.38679501
43	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.38062537
44	DCP1A_22483619_ChIP-Seq_HELA_Human	1.37789028
45	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.36818280
46	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.35429392
47	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.33837094
48	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.33239525
49	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.31360460
50	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.30656170
51	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29756815
52	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.29292264
53	BRD4_25478319_ChIP-Seq_HGPS_Human	1.28485636
54	EWS_26573619_Chip-Seq_HEK293_Human	1.27952125
55	CDX2_22108803_ChIP-Seq_LS180_Human	1.27208258
56	GATA4_25053715_ChIP-Seq_YYC3_Human	1.27083991
57	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.26157530
58	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.25862099
59	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.24307628
60	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.22977573
61	VDR_23849224_ChIP-Seq_CD4+_Human	1.22823365
62	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.22702262
63	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22549720
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21638886
65	TP53_18474530_ChIP-ChIP_U2OS_Human	1.21039073
66	TAF15_26573619_Chip-Seq_HEK293_Human	1.17714788
67	TFEB_21752829_ChIP-Seq_HELA_Human	1.17060548
68	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.16698299
69	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.14220648
70	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.12748532
71	EOMES_21245162_ChIP-Seq_HESCs_Human	1.12036846
72	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11348474
73	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.08893075
74	ZNF263_19887448_ChIP-Seq_K562_Human	1.08595217
75	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.07415450
76	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.07326657
77	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.06824493
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04010247
79	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.01506547
80	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.00725367
81	HTT_18923047_ChIP-ChIP_STHdh_Human	1.00718775
82	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	0.99272053
83	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	0.99272053
84	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.98121293
85	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.97978960
86	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.97777555
87	P300_19829295_ChIP-Seq_ESCs_Human	0.97576654
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.96321686
89	VDR_22108803_ChIP-Seq_LS180_Human	0.96103604
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95808167
91	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.95638874
92	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.93703665
93	ZNF274_21170338_ChIP-Seq_K562_Hela	0.93111772
94	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.92731413
95	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.92669549
96	ELF5_23300383_ChIP-Seq_T47D_Human	0.92070107
97	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.91566319
98	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.91530513
99	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.91241289
100	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.90857774

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006054_spinal_hemorrhage	4.17899913
2	MP0010234_abnormal_vibrissa_follicle	4.14777604
3	MP0008438_abnormal_cutaneous_collagen	3.84028202
4	MP0003195_calcinosis	3.14473341
5	MP0004272_abnormal_basement_membrane	3.11230908
6	MP0009780_abnormal_chondrocyte_physiolo	2.80755825
7	MP0002139_abnormal_hepatobiliary_system	2.69393546
8	MP0010352_gastrointestinal_tract_polyps	2.52571372
9	MP0005408_hypopigmentation	2.29246556
10	MP0003941_abnormal_skin_development	2.04434033
11	MP0008875_abnormal_xenobiotic_pharmacok	2.03018269
12	MP0003950_abnormal_plasma_membrane	2.02308950
13	MP0005623_abnormal_meninges_morphology	2.00527302
14	MP0010678_abnormal_skin_adnexa	1.98103318
15	MP0005360_urolithiasis	1.90692589
16	MP0000013_abnormal_adipose_tissue	1.84384259
17	MP0004019_abnormal_vitamin_homeostasis	1.79278830
18	MP0002837_dystrophic_cardiac_calcinosis	1.78402657
19	MP0005058_abnormal_lysosome_morphology	1.78242741
20	MP0003806_abnormal_nucleotide_metabolis	1.73613696
21	MP0003191_abnormal_cellular_cholesterol	1.70862438
22	MP0005275_abnormal_skin_tensile	1.62886580
23	MP0002282_abnormal_trachea_morphology	1.61880045
24	MP0005085_abnormal_gallbladder_physiolo	1.61748326
25	MP0002254_reproductive_system_inflammat	1.59153732
26	MP0005365_abnormal_bile_salt	1.57343653
27	MP0005379_endocrine/exocrine_gland_phen	1.56891743
28	MP0005332_abnormal_amino_acid	1.53887202
29	MP0005257_abnormal_intraocular_pressure	1.50734989
30	MP0005165_increased_susceptibility_to	1.50211960
31	MP0005367_renal/urinary_system_phenotyp	1.46892539
32	MP0000516_abnormal_urinary_system	1.46892539
33	MP0009697_abnormal_copulation	1.45705568
34	MP0009384_cardiac_valve_regurgitation	1.41419286
35	MP0002060_abnormal_skin_morphology	1.37698403
36	MP0002090_abnormal_vision	1.34753123
37	MP0003186_abnormal_redox_activity	1.33091604
38	MP0010329_abnormal_lipoprotein_level	1.32703562
39	MP0002909_abnormal_adrenal_gland	1.28662258
40	MP0009840_abnormal_foam_cell	1.23613834
41	MP0003122_maternal_imprinting	1.20926028
42	MP0002295_abnormal_pulmonary_circulatio	1.20794696
43	MP0005248_abnormal_Harderian_gland	1.17796898
44	MP0005197_abnormal_uvea_morphology	1.16742727
45	MP0003566_abnormal_cell_adhesion	1.15178240
46	MP0002168_other_aberrant_phenotype	1.13692053
47	MP0002163_abnormal_gland_morphology	1.13305116
48	MP0002166_altered_tumor_susceptibility	1.12819648
49	MP0002896_abnormal_bone_mineralization	1.12514324
50	MP0003279_aneurysm	1.09429215
51	MP0001661_extended_life_span	1.07351672
52	MP0003283_abnormal_digestive_organ	1.06754962
53	MP0004782_abnormal_surfactant_physiolog	1.06463281
54	MP0000358_abnormal_cell_content/	1.06013129
55	MP0002233_abnormal_nose_morphology	1.05358360
56	MP0002876_abnormal_thyroid_physiology	1.05209025
57	MP0000372_irregular_coat_pigmentation	1.04752294
58	MP0001666_abnormal_nutrient_absorption	1.03857444
59	MP0002006_tumorigenesis	1.03783386
60	MP0005503_abnormal_tendon_morphology	1.03188889
61	MP0006082_CNS_inflammation	1.01236885
62	MP0001542_abnormal_bone_strength	0.99770953
63	MP0001243_abnormal_dermal_layer	0.98980176
64	MP0002938_white_spotting	0.96831629
65	MP0000383_abnormal_hair_follicle	0.96511776
66	MP0005084_abnormal_gallbladder_morpholo	0.94511659
67	MP0001764_abnormal_homeostasis	0.93340239
68	MP0005508_abnormal_skeleton_morphology	0.93190428
69	MP0005395_other_phenotype	0.93098561
70	MP0000538_abnormal_urinary_bladder	0.93000177
71	MP0000427_abnormal_hair_cycle	0.91947367
72	MP0000639_abnormal_adrenal_gland	0.89666419
73	MP0005023_abnormal_wound_healing	0.88510420
74	MP0002877_abnormal_melanocyte_morpholog	0.88109723
75	MP0010307_abnormal_tumor_latency	0.87664492
76	MP0005636_abnormal_mineral_homeostasis	0.86832386
77	MP0000613_abnormal_salivary_gland	0.84978819
78	MP0005164_abnormal_response_to	0.84764215
79	MP0001299_abnormal_eye_distance/	0.84105573
80	MP0000003_abnormal_adipose_tissue	0.83883409
81	MP0001756_abnormal_urination	0.83334211
82	MP0000647_abnormal_sebaceous_gland	0.83280683
83	MP0001984_abnormal_olfaction	0.82906891
84	MP0003252_abnormal_bile_duct	0.81940339
85	MP0008932_abnormal_embryonic_tissue	0.80570067
86	MP0010386_abnormal_urinary_bladder	0.80115865
87	MP0003937_abnormal_limbs/digits/tail_de	0.78367919
88	MP0009643_abnormal_urine_homeostasis	0.78335821
89	MP0008789_abnormal_olfactory_epithelium	0.77677183
90	MP0005220_abnormal_exocrine_pancreas	0.76505280
91	MP0004957_abnormal_blastocyst_morpholog	0.74200499
92	MP0001216_abnormal_epidermal_layer	0.74078595
93	MP0003786_premature_aging	0.73523131
94	MP0010368_abnormal_lymphatic_system	0.73167090
95	MP0005193_abnormal_anterior_eye	0.72023236
96	MP0009053_abnormal_anal_canal	0.69986718
97	MP0002115_abnormal_skeleton_extremities	0.68707726
98	MP0003075_altered_response_to	0.66935093
99	MP0006072_abnormal_retinal_apoptosis	0.66286537
100	MP0004215_abnormal_myocardial_fiber	0.62366522

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature rupture of membranes (HP:0001788)	3.65656702
2	Vascular calcification (HP:0004934)	3.53326387
3	Cardiovascular calcification (HP:0011915)	3.47653791
4	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.43485132
5	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.23145211
6	Cutaneous melanoma (HP:0012056)	2.95427225
7	Rhinitis (HP:0012384)	2.92665298
8	Abnormality of vitamin B metabolism (HP:0004340)	2.77788562
9	Abnormal respiratory epithelium morphology (HP:0012253)	2.76618292
10	Abnormal respiratory motile cilium morphology (HP:0005938)	2.76618292
11	Mitral stenosis (HP:0001718)	2.75821349
12	Mucopolysacchariduria (HP:0008155)	2.73694093
13	Urinary glycosaminoglycan excretion (HP:0003541)	2.73694093
14	Vacuolated lymphocytes (HP:0001922)	2.67681593
15	Methylmalonic acidemia (HP:0002912)	2.61440339
16	Abnormality of polysaccharide metabolism (HP:0011012)	2.60358418
17	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.60358418
18	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.60358418
19	Abnormality of vitamin metabolism (HP:0100508)	2.60068835
20	Medial flaring of the eyebrow (HP:0010747)	2.57071119
21	Abnormality of glycolipid metabolism (HP:0010969)	2.56438489
22	Abnormality of liposaccharide metabolism (HP:0010968)	2.56438489
23	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.56438489
24	Abnormality of methionine metabolism (HP:0010901)	2.50086945
25	Abnormal respiratory motile cilium physiology (HP:0012261)	2.48823658
26	Nuclear cataract (HP:0100018)	2.48781775
27	Hypobetalipoproteinemia (HP:0003563)	2.48054236
28	Hypoglycemic coma (HP:0001325)	2.44699389
29	Abnormality of the distal phalanges of the toes (HP:0010182)	2.43574540
30	Proximal tubulopathy (HP:0000114)	2.43339358
31	Fat malabsorption (HP:0002630)	2.42956592
32	Steatorrhea (HP:0002570)	2.40792982
33	Delayed gross motor development (HP:0002194)	2.40706209
34	Intrahepatic cholestasis (HP:0001406)	2.40486669
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.39178672
36	Absent/shortened dynein arms (HP:0200106)	2.39178672
37	Adrenal hypoplasia (HP:0000835)	2.38363687
38	Congenital primary aphakia (HP:0007707)	2.32834650
39	Orthostatic hypotension (HP:0001278)	2.30903664
40	Right ventricular cardiomyopathy (HP:0011663)	2.24554332
41	Chronic bronchitis (HP:0004469)	2.23455736
42	Abnormal ciliary motility (HP:0012262)	2.23239124
43	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.21004861
44	Occipital encephalocele (HP:0002085)	2.20256818
45	Popliteal pterygium (HP:0009756)	2.19240636
46	Cervical subluxation (HP:0003308)	2.18499104
47	Beaking of vertebral bodies (HP:0004568)	2.12389935
48	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.11930820
49	Nephrogenic diabetes insipidus (HP:0009806)	2.10102888
50	Palpitations (HP:0001962)	2.08610705
51	Hypophosphatemic rickets (HP:0004912)	2.06207894
52	Hypothermia (HP:0002045)	2.06184771
53	Abnormality of dentin (HP:0010299)	2.03042785
54	Ankle contracture (HP:0006466)	2.01923033
55	Methylmalonic aciduria (HP:0012120)	1.97867259
56	True hermaphroditism (HP:0010459)	1.96667917
57	Pterygium (HP:0001059)	1.96432142
58	Abnormality of the umbilical cord (HP:0010881)	1.95843724
59	Nausea (HP:0002018)	1.95735157
60	Disproportionate short-trunk short stature (HP:0003521)	1.94350240
61	Vertebral compression fractures (HP:0002953)	1.88654810
62	Prolonged partial thromboplastin time (HP:0003645)	1.87948103
63	Gait imbalance (HP:0002141)	1.87046367
64	Aortic dissection (HP:0002647)	1.85170607
65	Bronchiectasis (HP:0002110)	1.84616456
66	Abnormality of urine glucose concentration (HP:0011016)	1.84489202
67	Glycosuria (HP:0003076)	1.84489202
68	Zonular cataract (HP:0010920)	1.84358165
69	Metaphyseal dysplasia (HP:0100255)	1.82418282
70	Pancreatic islet-cell hyperplasia (HP:0004510)	1.81894036
71	Hyperglycemia (HP:0003074)	1.80689129
72	Increased serum pyruvate (HP:0003542)	1.79848359
73	Pancreatic fibrosis (HP:0100732)	1.79085956
74	Abnormal protein N-linked glycosylation (HP:0012347)	1.78719581
75	Abnormal protein glycosylation (HP:0012346)	1.78719581
76	Abnormal glycosylation (HP:0012345)	1.78719581
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.78719581
78	Arterial tortuosity (HP:0005116)	1.78440715
79	Epiphyseal stippling (HP:0010655)	1.78192582
80	Tongue fasciculations (HP:0001308)	1.77218885
81	Abnormality of the fetal cardiovascular system (HP:0010948)	1.76020679
82	Abnormal umbilical cord blood vessels (HP:0011403)	1.76020679
83	Single umbilical artery (HP:0001195)	1.76020679
84	Asymmetry of the thorax (HP:0001555)	1.74972527
85	Megaloblastic anemia (HP:0001889)	1.74109775
86	Abnormalities of placenta or umbilical cord (HP:0001194)	1.74051022
87	Dysostosis multiplex (HP:0000943)	1.70745197
88	Hypoglycemic seizures (HP:0002173)	1.70625746
89	Progressive neurologic deterioration (HP:0002344)	1.70551395
90	Hypolipoproteinemia (HP:0010981)	1.70548313
91	Symptomatic seizures (HP:0011145)	1.69657756
92	Vaginal atresia (HP:0000148)	1.68879683
93	Genital tract atresia (HP:0001827)	1.67645070
94	Follicular hyperkeratosis (HP:0007502)	1.67319611
95	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	1.66895928
96	Vertebral hypoplasia (HP:0008417)	1.66895928
97	Generalized aminoaciduria (HP:0002909)	1.66634132
98	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.65962217
99	Osteolytic defects of the hand bones (HP:0009699)	1.65962217
100	Glucose intolerance (HP:0000833)	1.65729991

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	3.40895876
2	EIF2AK3	2.81674196
3	TRIM28	2.63255555
4	ERBB3	2.60046107
5	FRK	2.46080361
6	EIF2AK1	2.38190906
7	LIMK1	2.36806132
8	ACVR1B	2.35637839
9	TESK1	2.31006687
10	BCR	2.30582487
11	NEK1	2.17615701
12	BCKDK	2.11956392
13	MST1R	1.87130480
14	CSNK1G1	1.76557147
15	FER	1.72202237
16	PLK3	1.65613096
17	PLK2	1.59288228
18	MAP3K12	1.56987047
19	BUB1	1.50633552
20	BRSK2	1.50504338
21	PAK4	1.49839412
22	TSSK6	1.44060824
23	CSNK1G3	1.42461633
24	TTK	1.41826016
25	FGFR2	1.40281174
26	WNK3	1.35924533
27	SRPK1	1.34733988
28	EPHA2	1.32851451
29	NEK9	1.29777078
30	STK38L	1.28102286
31	NUAK1	1.27951362
32	FGFR3	1.25722757
33	STK3	1.25168497
34	ERBB4	1.24397427
35	MYLK	1.16790608
36	MUSK	1.16005032
37	CSNK1G2	1.15750446
38	MET	1.14788123
39	MAP4K2	1.14294978
40	MAPKAPK3	1.11987108
41	CSNK1A1L	1.11351986
42	PDK2	1.11324839
43	STK16	1.10434902
44	NLK	1.08803266
45	PBK	1.07326326
46	PRKCE	1.06572964
47	MKNK1	1.06171034
48	STK39	1.03478067
49	IRAK3	1.00449737
50	GRK7	0.96395233
51	ADRBK2	0.95683931
52	TGFBR2	0.95082536
53	BMPR1B	0.93203093
54	PIM2	0.92791014
55	RPS6KA4	0.91341388
56	MKNK2	0.90993876
57	GRK1	0.90758006
58	DDR2	0.90636146
59	VRK2	0.90561091
60	LATS1	0.90080209
61	STK24	0.86525881
62	WEE1	0.86024800
63	PLK1	0.85854041
64	STK10	0.85306644
65	MOS	0.79621407
66	FGFR1	0.77615730
67	MAPK15	0.77446312
68	BMPR2	0.74753305
69	EPHA3	0.72173587
70	ARAF	0.67499421
71	SIK3	0.67203747
72	PTK2	0.63617997
73	FGFR4	0.61645274
74	MAP3K2	0.61022114
75	LMTK2	0.60920543
76	MAP3K14	0.60536069
77	EPHB2	0.56496070
78	PAK3	0.55858493
79	TRPM7	0.53978608
80	STK4	0.53275612
81	GSK3A	0.52962229
82	NME2	0.52362507
83	PLK4	0.51181662
84	CDK3	0.50548929
85	VRK1	0.50090271
86	YES1	0.47946539
87	DYRK3	0.46118342
88	OXSR1	0.45254954
89	CDK6	0.45213994
90	TBK1	0.44351742
91	EIF2AK2	0.43741199
92	BRSK1	0.42250464
93	TGFBR1	0.41693247
94	CDK8	0.40136326
95	PDGFRA	0.39702645
96	PRKCI	0.38966202
97	CSNK2A1	0.37457709
98	MAP2K7	0.37113859
99	FLT3	0.36982636
100	CAMK2D	0.35963746

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.42912348
2	Sulfur metabolism_Homo sapiens_hsa00920	2.67209745
3	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.41719475
4	Proteasome_Homo sapiens_hsa03050	2.39635092
5	Fatty acid elongation_Homo sapiens_hsa00062	2.28480113
6	Propanoate metabolism_Homo sapiens_hsa00640	2.28444742
7	Folate biosynthesis_Homo sapiens_hsa00790	2.14925812
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.06031736
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.99901414
10	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.88203296
11	Glutathione metabolism_Homo sapiens_hsa00480	1.84481483
12	Steroid biosynthesis_Homo sapiens_hsa00100	1.79306297
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.77565004
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.75356185
15	Sphingolipid metabolism_Homo sapiens_hsa00600	1.67387112
16	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.67260352
17	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.66769947
18	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.63895058
19	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.58172011
20	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.57997366
21	Complement and coagulation cascades_Homo sapiens_hsa04610	1.57821138
22	Other glycan degradation_Homo sapiens_hsa00511	1.54972912
23	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.52456775
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.48979764
25	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.46102023
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.45588587
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.43533695
28	Peroxisome_Homo sapiens_hsa04146	1.41864121
29	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.41111749
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.39773027
31	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.39448362
32	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.37871531
33	Pyruvate metabolism_Homo sapiens_hsa00620	1.36442882
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.34606690
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.33843334
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31766759
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.29564600
38	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.28720950
39	Fatty acid degradation_Homo sapiens_hsa00071	1.26801020
40	Non-homologous end-joining_Homo sapiens_hsa03450	1.25538545
41	Galactose metabolism_Homo sapiens_hsa00052	1.24081730
42	Caffeine metabolism_Homo sapiens_hsa00232	1.23169642
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.22033317
44	Fatty acid metabolism_Homo sapiens_hsa01212	1.20950167
45	Lysosome_Homo sapiens_hsa04142	1.16503619
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.16232750
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.16148885
48	Vibrio cholerae infection_Homo sapiens_hsa05110	1.14481236
49	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.10633853
50	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.09278211
51	Mineral absorption_Homo sapiens_hsa04978	1.08679541
52	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.07675574
53	Renin-angiotensin system_Homo sapiens_hsa04614	1.03951881
54	Carbon metabolism_Homo sapiens_hsa01200	1.02184216
55	One carbon pool by folate_Homo sapiens_hsa00670	1.01911133
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.98564594
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.97683888
58	Tyrosine metabolism_Homo sapiens_hsa00350	0.95947799
59	Phenylalanine metabolism_Homo sapiens_hsa00360	0.94864342
60	Retinol metabolism_Homo sapiens_hsa00830	0.94792055
61	Butanoate metabolism_Homo sapiens_hsa00650	0.91982311
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89247432
63	Nucleotide excision repair_Homo sapiens_hsa03420	0.87365454
64	Arginine and proline metabolism_Homo sapiens_hsa00330	0.86395120
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.82605968
66	Metabolic pathways_Homo sapiens_hsa01100	0.79844167
67	Oxidative phosphorylation_Homo sapiens_hsa00190	0.79065000
68	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.77311269
69	Histidine metabolism_Homo sapiens_hsa00340	0.75406156
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.74463500
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72175268
72	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.70645469
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.70326815
74	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.67857242
75	Protein digestion and absorption_Homo sapiens_hsa04974	0.64683408
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.64003421
77	Legionellosis_Homo sapiens_hsa05134	0.58452929
78	Pentose phosphate pathway_Homo sapiens_hsa00030	0.57584659
79	p53 signaling pathway_Homo sapiens_hsa04115	0.55080995
80	Rheumatoid arthritis_Homo sapiens_hsa05323	0.54021114
81	ECM-receptor interaction_Homo sapiens_hsa04512	0.53481529
82	Purine metabolism_Homo sapiens_hsa00230	0.51909381
83	RNA degradation_Homo sapiens_hsa03018	0.50924188
84	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.50819729
85	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.50325295
86	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.49969848
87	PPAR signaling pathway_Homo sapiens_hsa03320	0.49529973
88	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.49242564
89	Circadian rhythm_Homo sapiens_hsa04710	0.47672873
90	Basal transcription factors_Homo sapiens_hsa03022	0.46643942
91	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.45787193
92	Pertussis_Homo sapiens_hsa05133	0.44794401
93	Mismatch repair_Homo sapiens_hsa03430	0.44706850
94	Pyrimidine metabolism_Homo sapiens_hsa00240	0.43846418
95	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.42092239
96	RNA polymerase_Homo sapiens_hsa03020	0.40534455
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40053254
98	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.39870912
99	Huntingtons disease_Homo sapiens_hsa05016	0.36802580
100	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.35382667

C5ORF15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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