C5ORF22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.54396284
2nuclear pore organization (GO:0006999)4.39316929
3nuclear pore complex assembly (GO:0051292)4.33124929
4CENP-A containing nucleosome assembly (GO:0034080)4.31724733
5chromatin remodeling at centromere (GO:0031055)4.23402397
6ribosome assembly (GO:0042255)4.17759760
7cullin deneddylation (GO:0010388)4.17517833
8DNA replication checkpoint (GO:0000076)4.15823345
9DNA double-strand break processing (GO:0000729)4.05619231
10protein localization to kinetochore (GO:0034501)4.02704697
11mitotic metaphase plate congression (GO:0007080)3.87425594
12protein deneddylation (GO:0000338)3.83979322
13metaphase plate congression (GO:0051310)3.77919529
14mitotic sister chromatid cohesion (GO:0007064)3.77127874
15double-strand break repair via nonhomologous end joining (GO:0006303)3.75701600
16non-recombinational repair (GO:0000726)3.75701600
17histone exchange (GO:0043486)3.75106144
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.74458111
19purine nucleobase biosynthetic process (GO:0009113)3.73705492
20regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.68405784
21spindle checkpoint (GO:0031577)3.66508639
22DNA strand elongation involved in DNA replication (GO:0006271)3.63056819
23mitotic sister chromatid segregation (GO:0000070)3.62010468
24sister chromatid segregation (GO:0000819)3.60412345
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.58596051
26regulation of mitotic spindle checkpoint (GO:1903504)3.58577510
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.58577510
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.58492811
29negative regulation of DNA-dependent DNA replication (GO:2000104)3.55470589
30IMP biosynthetic process (GO:0006188)3.53244814
31regulation of DNA endoreduplication (GO:0032875)3.51007561
32telomere maintenance via semi-conservative replication (GO:0032201)3.50377939
33mitotic spindle checkpoint (GO:0071174)3.49963140
34replication fork processing (GO:0031297)3.49122264
35DNA strand elongation (GO:0022616)3.49066249
36regulation of centriole replication (GO:0046599)3.48552908
37establishment of integrated proviral latency (GO:0075713)3.46436308
38protein localization to chromosome, centromeric region (GO:0071459)3.45703672
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44320457
40DNA replication-independent nucleosome organization (GO:0034724)3.42926503
41DNA replication-independent nucleosome assembly (GO:0006336)3.42926503
42DNA replication-dependent nucleosome assembly (GO:0006335)3.40873339
43DNA replication-dependent nucleosome organization (GO:0034723)3.40873339
44mitotic nuclear envelope disassembly (GO:0007077)3.39778179
45regulation of helicase activity (GO:0051095)3.38665756
46DNA ligation (GO:0006266)3.37971154
47nucleobase biosynthetic process (GO:0046112)3.36547349
48pore complex assembly (GO:0046931)3.36083158
49DNA catabolic process, exonucleolytic (GO:0000738)3.34319361
50negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.31627948
51negative regulation of mitotic sister chromatid segregation (GO:0033048)3.31627948
52negative regulation of mitotic sister chromatid separation (GO:2000816)3.31627948
53negative regulation of sister chromatid segregation (GO:0033046)3.31627948
54negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.31627948
55establishment of chromosome localization (GO:0051303)3.29193386
56somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.28981546
57somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.28981546
58isotype switching (GO:0045190)3.28981546
59negative regulation of chromosome segregation (GO:0051985)3.28505905
60negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.26456309
61negative regulation of ligase activity (GO:0051352)3.26456309
62kinetochore organization (GO:0051383)3.23747330
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.23609330
64regulation of mitotic metaphase/anaphase transition (GO:0030071)3.23609330
65histone H2A acetylation (GO:0043968)3.23459130
66mitotic recombination (GO:0006312)3.20299738
67spindle assembly checkpoint (GO:0071173)3.19393277
68protein K6-linked ubiquitination (GO:0085020)3.18691168
69mitotic spindle assembly checkpoint (GO:0007094)3.18642044
70synapsis (GO:0007129)3.18512282
71IMP metabolic process (GO:0046040)3.18001790
72regulation of chromosome segregation (GO:0051983)3.17982659
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.16602933
74somatic hypermutation of immunoglobulin genes (GO:0016446)3.16179235
75somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16179235
76telomere maintenance via recombination (GO:0000722)3.15779352
77attachment of spindle microtubules to kinetochore (GO:0008608)3.15398467
78negative regulation of DNA recombination (GO:0045910)3.15085056
79mitochondrial RNA metabolic process (GO:0000959)3.12957425
80regulation of mitotic sister chromatid separation (GO:0010965)3.11372998
81regulation of mitotic sister chromatid segregation (GO:0033047)3.11372998
82regulation of sister chromatid segregation (GO:0033045)3.11372998
83tRNA aminoacylation for protein translation (GO:0006418)3.10869530
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.10547803
85amino acid activation (GO:0043038)3.10490903
86tRNA aminoacylation (GO:0043039)3.10490903
87nuclear envelope disassembly (GO:0051081)3.09630623
88membrane disassembly (GO:0030397)3.09630623
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.07789630
90regulation of cellular amino acid metabolic process (GO:0006521)3.06063845
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03306407
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03306407
93signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03306407
94mitotic G2/M transition checkpoint (GO:0044818)2.99929261
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99201148
96signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99201148
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98388831
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.96405537
99signal transduction involved in DNA integrity checkpoint (GO:0072401)2.92685131
100signal transduction involved in DNA damage checkpoint (GO:0072422)2.92685131

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.60077171
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.51114148
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.86991302
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.46805771
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.92180011
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.87729149
7ELK1_19687146_ChIP-ChIP_HELA_Human2.80981380
8PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.76987458
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75932834
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.70887556
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69940403
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51337721
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.49752234
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44369187
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37047284
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.35435000
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26911124
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22967709
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20253658
20AR_21909140_ChIP-Seq_LNCAP_Human2.18201263
21FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.16441268
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.14246661
23PADI4_21655091_ChIP-ChIP_MCF-7_Human2.12545731
24VDR_23849224_ChIP-Seq_CD4+_Human2.07855326
25FOXP3_21729870_ChIP-Seq_TREG_Human1.97936679
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94872266
27* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92721232
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90001756
29FUS_26573619_Chip-Seq_HEK293_Human1.87757247
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83096951
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78080792
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77921987
33EWS_26573619_Chip-Seq_HEK293_Human1.77038092
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.76963288
35DCP1A_22483619_ChIP-Seq_HELA_Human1.76228317
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74177970
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70384951
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61236994
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58028045
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52327976
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52306182
42ZNF274_21170338_ChIP-Seq_K562_Hela1.50976527
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.49200696
44GABP_19822575_ChIP-Seq_HepG2_Human1.49133323
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.48882238
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46381675
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45973172
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44214010
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39379162
50* MYC_18940864_ChIP-ChIP_HL60_Human1.39309063
51TAF15_26573619_Chip-Seq_HEK293_Human1.29805121
52VDR_22108803_ChIP-Seq_LS180_Human1.29575380
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29319357
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26166472
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25709699
56IGF1R_20145208_ChIP-Seq_DFB_Human1.25527323
57TTF2_22483619_ChIP-Seq_HELA_Human1.24075070
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21751854
59P300_19829295_ChIP-Seq_ESCs_Human1.20420538
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.19484528
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18176074
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16580344
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14555202
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13087178
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08912024
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08378736
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08014988
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06140206
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05158224
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.04534755
71KDM5A_27292631_Chip-Seq_BREAST_Human1.00922627
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00603643
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.00046683
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98259063
75* TFEB_21752829_ChIP-Seq_HELA_Human0.95851204
76SOX17_20123909_ChIP-Seq_XEN_Mouse0.95719020
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95605525
78* XRN2_22483619_ChIP-Seq_HELA_Human0.92666827
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91354496
80ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90495321
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86879856
82POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83146507
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81909155
84SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81418992
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79936409
86YY1_21170310_ChIP-Seq_MESCs_Mouse0.78904395
87IRF1_19129219_ChIP-ChIP_H3396_Human0.78896408
88SALL4_22934838_ChIP-ChIP_CD34+_Human0.78325886
89ELF5_23300383_ChIP-Seq_T47D_Human0.78283387
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.78227155
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77882654
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.77453338
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77142123
94CRX_20693478_ChIP-Seq_RETINA_Mouse0.76415455
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.76370641
96NANOG_18555785_ChIP-Seq_MESCs_Mouse0.75770761
97GBX2_23144817_ChIP-Seq_PC3_Human0.75653730
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74041318
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.73119316
100CBP_20019798_ChIP-Seq_JUKART_Human0.71809297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.30979275
2MP0008057_abnormal_DNA_replication4.21600029
3MP0008058_abnormal_DNA_repair4.05460334
4MP0000372_irregular_coat_pigmentation3.94849203
5MP0003693_abnormal_embryo_hatching3.83153637
6MP0002102_abnormal_ear_morphology3.51250925
7MP0004957_abnormal_blastocyst_morpholog3.50569848
8MP0003111_abnormal_nucleus_morphology3.27285080
9MP0003077_abnormal_cell_cycle3.04237639
10MP0009697_abnormal_copulation2.77272751
11MP0008932_abnormal_embryonic_tissue2.66548760
12MP0003806_abnormal_nucleotide_metabolis2.49677150
13MP0003890_abnormal_embryonic-extraembry2.49295613
14MP0008877_abnormal_DNA_methylation2.45257957
15MP0003718_maternal_effect2.33632421
16MP0008007_abnormal_cellular_replicative2.17812820
17MP0005075_abnormal_melanosome_morpholog2.15818444
18MP0005408_hypopigmentation2.10046500
19MP0005171_absent_coat_pigmentation2.09957749
20MP0000015_abnormal_ear_pigmentation1.73211412
21MP0003786_premature_aging1.72023423
22MP0002938_white_spotting1.69875380
23MP0003941_abnormal_skin_development1.63359125
24MP0003136_yellow_coat_color1.61720176
25MP0006036_abnormal_mitochondrial_physio1.51602585
26MP0001697_abnormal_embryo_size1.47792672
27MP0001293_anophthalmia1.44867537
28MP0001730_embryonic_growth_arrest1.43770966
29MP0000350_abnormal_cell_proliferation1.42220440
30MP0006035_abnormal_mitochondrial_morpho1.40639948
31MP0001672_abnormal_embryogenesis/_devel1.38104851
32MP0005380_embryogenesis_phenotype1.38104851
33MP0010352_gastrointestinal_tract_polyps1.32388347
34MP0001324_abnormal_eye_pigmentation1.30819379
35MP0003186_abnormal_redox_activity1.30794163
36MP0006054_spinal_hemorrhage1.29832652
37MP0002084_abnormal_developmental_patter1.29668100
38MP0002877_abnormal_melanocyte_morpholog1.27903975
39MP0010307_abnormal_tumor_latency1.24500644
40MP0003937_abnormal_limbs/digits/tail_de1.23610024
41MP0003646_muscle_fatigue1.23309048
42MP0000358_abnormal_cell_content/1.19389240
43MP0003984_embryonic_growth_retardation1.18804145
44MP0002088_abnormal_embryonic_growth/wei1.16910153
45MP0003567_abnormal_fetal_cardiomyocyte1.14727701
46MP0000569_abnormal_digit_pigmentation1.12316020
47MP0003950_abnormal_plasma_membrane1.11985203
48MP0004147_increased_porphyrin_level1.11967264
49MP0002095_abnormal_skin_pigmentation1.11152746
50MP0001188_hyperpigmentation1.10854017
51MP0002080_prenatal_lethality1.10577057
52MP0000371_diluted_coat_color1.10206475
53MP0002085_abnormal_embryonic_tissue1.08381361
54MP0001529_abnormal_vocalization1.08325896
55MP0004197_abnormal_fetal_growth/weight/1.06856215
56MP0005174_abnormal_tail_pigmentation1.05996553
57MP0000647_abnormal_sebaceous_gland1.05959141
58MP0004215_abnormal_myocardial_fiber1.05063997
59MP0003195_calcinosis1.05013503
60MP0000516_abnormal_urinary_system1.02019631
61MP0005367_renal/urinary_system_phenotyp1.02019631
62MP0003221_abnormal_cardiomyocyte_apopto1.00157645
63MP0001929_abnormal_gametogenesis0.96998459
64MP0001984_abnormal_olfaction0.95800211
65MP0009672_abnormal_birth_weight0.93983382
66MP0001661_extended_life_span0.92957102
67MP0000313_abnormal_cell_death0.92060739
68MP0003943_abnormal_hepatobiliary_system0.91150237
69MP0001286_abnormal_eye_development0.91058025
70MP0003119_abnormal_digestive_system0.88965676
71MP0002233_abnormal_nose_morphology0.88477458
72MP0005187_abnormal_penis_morphology0.86377133
73MP0008789_abnormal_olfactory_epithelium0.85837631
74MP0002090_abnormal_vision0.85602011
75MP0002086_abnormal_extraembryonic_tissu0.84650222
76MP0002160_abnormal_reproductive_system0.84510354
77MP0002210_abnormal_sex_determination0.82766144
78MP0005395_other_phenotype0.79914449
79MP0009703_decreased_birth_body0.77653974
80MP0005253_abnormal_eye_physiology0.77129544
81MP0004233_abnormal_muscle_weight0.76858851
82MP0005384_cellular_phenotype0.75498419
83MP0000653_abnormal_sex_gland0.75183927
84MP0002837_dystrophic_cardiac_calcinosis0.74280585
85MP0002751_abnormal_autonomic_nervous0.73079938
86MP0001145_abnormal_male_reproductive0.71597550
87MP0003137_abnormal_impulse_conducting0.70443129
88MP0004084_abnormal_cardiac_muscle0.68964209
89MP0002019_abnormal_tumor_incidence0.68829222
90MP0010030_abnormal_orbit_morphology0.67162822
91MP0003755_abnormal_palate_morphology0.66522364
92MP0001119_abnormal_female_reproductive0.66191220
93MP0010678_abnormal_skin_adnexa0.66145376
94MP0006292_abnormal_olfactory_placode0.65910211
95MP0005248_abnormal_Harderian_gland0.65291554
96MP0002234_abnormal_pharynx_morphology0.64978064
97MP0005394_taste/olfaction_phenotype0.64947957
98MP0005499_abnormal_olfactory_system0.64947957
99MP0003656_abnormal_erythrocyte_physiolo0.64929129
100MP0005266_abnormal_metabolism0.64080556

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.29256334
2Chromsome breakage (HP:0040012)4.14312413
3Abnormality of chromosome stability (HP:0003220)3.67695239
4Aplasia/Hypoplasia of the uvula (HP:0010293)3.14219809
5Meckel diverticulum (HP:0002245)3.08913729
6Volvulus (HP:0002580)3.03711282
7Abnormal lung lobation (HP:0002101)2.93669116
8Ependymoma (HP:0002888)2.91924912
9Abnormality of the ileum (HP:0001549)2.91852819
10Abnormality of methionine metabolism (HP:0010901)2.90625749
11Birth length less than 3rd percentile (HP:0003561)2.89676463
12Abnormality of the preputium (HP:0100587)2.82879957
13Neoplasm of the adrenal gland (HP:0100631)2.79488310
14Rhabdomyosarcoma (HP:0002859)2.73162050
15Small intestinal stenosis (HP:0012848)2.71867004
16Duodenal stenosis (HP:0100867)2.71867004
17Glioma (HP:0009733)2.70562659
18Colon cancer (HP:0003003)2.67742260
19Abnormality of the astrocytes (HP:0100707)2.66053971
20Astrocytoma (HP:0009592)2.66053971
21Abnormality of the labia minora (HP:0012880)2.61857637
22Nephroblastoma (Wilms tumor) (HP:0002667)2.57791487
23Cortical dysplasia (HP:0002539)2.54149508
24Abnormal auditory evoked potentials (HP:0006958)2.51004635
25Medulloblastoma (HP:0002885)2.47112333
26Abnormality of glycolysis (HP:0004366)2.46329287
27Abnormality of the duodenum (HP:0002246)2.45905269
28Embryonal renal neoplasm (HP:0011794)2.45200858
29Bifid tongue (HP:0010297)2.42899933
30Methylmalonic acidemia (HP:0002912)2.41937946
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39596094
32Abnormal protein N-linked glycosylation (HP:0012347)2.39596094
33Abnormal protein glycosylation (HP:0012346)2.39596094
34Abnormal glycosylation (HP:0012345)2.39596094
35Sloping forehead (HP:0000340)2.36698561
36Increased hepatocellular lipid droplets (HP:0006565)2.35958114
37Type I transferrin isoform profile (HP:0003642)2.35911930
38Abnormality of aspartate family amino acid metabolism (HP:0010899)2.30987837
39Hypoplasia of the fovea (HP:0007750)2.23100935
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.23100935
41Neoplasm of the adrenal cortex (HP:0100641)2.22543380
42Lipid accumulation in hepatocytes (HP:0006561)2.22065701
43Increased CSF lactate (HP:0002490)2.21570945
44Progressive inability to walk (HP:0002505)2.19005638
45Abnormality of the anterior horn cell (HP:0006802)2.18434959
46Degeneration of anterior horn cells (HP:0002398)2.18434959
47Abnormality of serum amino acid levels (HP:0003112)2.17799387
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16545210
49Abnormality of alanine metabolism (HP:0010916)2.16545210
50Hyperalaninemia (HP:0003348)2.16545210
51Myelodysplasia (HP:0002863)2.14977225
52Papillary thyroid carcinoma (HP:0002895)2.14943805
53Patchy hypopigmentation of hair (HP:0011365)2.09699740
54Neoplasm of the colon (HP:0100273)2.08808615
55Increased serum pyruvate (HP:0003542)2.08713251
56Hypoplastic pelvis (HP:0008839)2.07761271
57Acute encephalopathy (HP:0006846)2.05895417
58Abnormality of the fovea (HP:0000493)2.03295558
59Cerebral edema (HP:0002181)2.01535838
60Methylmalonic aciduria (HP:0012120)2.00193254
61Acute necrotizing encephalopathy (HP:0006965)1.98858534
62Increased serum lactate (HP:0002151)1.95757054
63Freckling (HP:0001480)1.94219075
64Postnatal microcephaly (HP:0005484)1.92469298
65Thyroid carcinoma (HP:0002890)1.92327753
66Intestinal atresia (HP:0011100)1.89882390
67Exercise-induced muscle cramps (HP:0003710)1.88087237
68Abnormal mitochondria in muscle tissue (HP:0008316)1.86182359
69Gonadotropin excess (HP:0000837)1.85828741
70Clubbing of toes (HP:0100760)1.85111566
71White forelock (HP:0002211)1.85057593
72Microvesicular hepatic steatosis (HP:0001414)1.84241198
73Absent radius (HP:0003974)1.80564234
74Proximal tubulopathy (HP:0000114)1.78735127
75Deep philtrum (HP:0002002)1.78355678
76Ovarian neoplasm (HP:0100615)1.77470616
77Abnormality of the carotid arteries (HP:0005344)1.76326030
78Renal Fanconi syndrome (HP:0001994)1.76276872
79Breast carcinoma (HP:0003002)1.76059223
80Astigmatism (HP:0000483)1.75886559
81Triphalangeal thumb (HP:0001199)1.75314165
82Long clavicles (HP:0000890)1.73831631
83Aplasia involving forearm bones (HP:0009822)1.73079932
84Absent forearm bone (HP:0003953)1.73079932
85Abnormality of homocysteine metabolism (HP:0010919)1.73023553
86Homocystinuria (HP:0002156)1.73023553
87Megaloblastic anemia (HP:0001889)1.72686806
88Medial flaring of the eyebrow (HP:0010747)1.72206269
89Progressive macrocephaly (HP:0004481)1.72134251
90Mitochondrial inheritance (HP:0001427)1.72091608
91Small hand (HP:0200055)1.71704976
92Pancreatic islet-cell hyperplasia (HP:0004510)1.71655420
93Cutaneous melanoma (HP:0012056)1.71427920
94Multiple enchondromatosis (HP:0005701)1.71357647
95Reduced antithrombin III activity (HP:0001976)1.69085330
96Albinism (HP:0001022)1.69022975
97Sensory axonal neuropathy (HP:0003390)1.68759206
98Increased nuchal translucency (HP:0010880)1.67751613
99Median cleft lip (HP:0000161)1.66104872
100Aplasia/Hypoplasia of the macula (HP:0008059)1.65454774

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.16252436
2BUB13.39163781
3EIF2AK13.27867025
4PBK3.09698605
5NEK12.89226245
6WEE12.79547108
7SIK32.53769493
8MST42.53682477
9TTK2.52300037
10SRPK12.46957025
11EIF2AK32.39319475
12TSSK62.35675865
13BRSK22.30746946
14PLK32.29101060
15CDC72.28787461
16BCR2.22641048
17NUAK12.10861624
18WNK32.06284892
19ERBB31.91699525
20TAF11.89259257
21PLK41.82194293
22MKNK11.82139557
23ZAK1.77005009
24ACVR1B1.76133427
25PDK21.71741133
26MKNK21.70384351
27BMPR1B1.64545535
28PLK21.52197791
29PLK11.49170096
30FRK1.40387206
31STK31.32357561
32VRK21.32041176
33MAP4K21.31922207
34BRSK11.25740232
35ERBB41.24560469
36TNIK1.18323509
37STK38L1.16951222
38ATR1.13972871
39LATS11.11986429
40MAP3K121.06451158
41EIF2AK20.99233513
42RPS6KA40.97736959
43CHEK20.95061135
44CCNB10.94108174
45CSNK1G10.92374514
46CSNK1G30.87207228
47BRD40.86384613
48KSR10.83185965
49CSNK1A1L0.82870863
50CSNK1G20.80258482
51AURKB0.79365923
52ATM0.77485920
53CHEK10.76932298
54STK160.74653339
55STK390.70962837
56CLK10.70125701
57CDK70.68187891
58FER0.68008691
59STK100.65797754
60VRK10.64034763
61MAP3K40.63225470
62MARK30.63102967
63TGFBR10.61583911
64MELK0.57410338
65CDK90.55687962
66CASK0.54891994
67MAPK130.54476327
68NME10.50777725
69SCYL20.50474042
70STK240.50147757
71MAP2K70.49616386
72STK40.49297185
73DAPK10.49114252
74PINK10.47830897
75BCKDK0.46847692
76FLT30.45526649
77OXSR10.45109387
78DYRK30.44745963
79CDK30.43085819
80PASK0.42270385
81CSNK2A10.39984411
82YES10.39865350
83MINK10.39850199
84OBSCN0.37606664
85ALK0.36814109
86CDK10.36085321
87CDK60.34545296
88MST1R0.34064484
89PRKCE0.33772119
90RAF10.32086988
91MAP3K80.31867731
92CDK20.30831319
93MET0.30070289
94CSNK2A20.29553281
95CSNK1E0.29202979
96MAPKAPK50.28632056
97BMPR20.28171278
98NEK20.27804306
99PAK30.27780147
100PNCK0.26863348

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.18727513
2Mismatch repair_Homo sapiens_hsa034303.64366817
3Non-homologous end-joining_Homo sapiens_hsa034503.47691447
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.07510154
5DNA replication_Homo sapiens_hsa030303.04019840
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03706243
7Protein export_Homo sapiens_hsa030602.85955852
8Homologous recombination_Homo sapiens_hsa034402.64949061
9Basal transcription factors_Homo sapiens_hsa030222.34816539
10RNA transport_Homo sapiens_hsa030132.32148366
11Cell cycle_Homo sapiens_hsa041102.26910670
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.26422081
13Fanconi anemia pathway_Homo sapiens_hsa034602.23117296
14Nucleotide excision repair_Homo sapiens_hsa034202.13900761
15Propanoate metabolism_Homo sapiens_hsa006402.09333341
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94399442
17RNA polymerase_Homo sapiens_hsa030201.92452889
18Base excision repair_Homo sapiens_hsa034101.92012676
19RNA degradation_Homo sapiens_hsa030181.91576580
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84744476
21One carbon pool by folate_Homo sapiens_hsa006701.83150592
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.77898343
23Fatty acid elongation_Homo sapiens_hsa000621.74789155
24Selenocompound metabolism_Homo sapiens_hsa004501.65260352
25Spliceosome_Homo sapiens_hsa030401.64956544
26Pyruvate metabolism_Homo sapiens_hsa006201.62869109
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61334543
28Vitamin B6 metabolism_Homo sapiens_hsa007501.56115801
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54783132
30Sulfur metabolism_Homo sapiens_hsa009201.54260316
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47236450
32Steroid biosynthesis_Homo sapiens_hsa001001.40142756
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32530521
34Pyrimidine metabolism_Homo sapiens_hsa002401.32081686
35p53 signaling pathway_Homo sapiens_hsa041151.30961951
36mRNA surveillance pathway_Homo sapiens_hsa030151.24689379
37Biosynthesis of amino acids_Homo sapiens_hsa012301.22881270
38Oocyte meiosis_Homo sapiens_hsa041141.21964597
39Carbon metabolism_Homo sapiens_hsa012001.18644600
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17645246
41Purine metabolism_Homo sapiens_hsa002301.16487554
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14863147
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12040779
44Parkinsons disease_Homo sapiens_hsa050121.05347486
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00087633
46Oxidative phosphorylation_Homo sapiens_hsa001900.98867444
47Folate biosynthesis_Homo sapiens_hsa007900.95348122
48Glutathione metabolism_Homo sapiens_hsa004800.87931067
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86447503
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81097166
51Huntingtons disease_Homo sapiens_hsa050160.79049699
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77858487
53Peroxisome_Homo sapiens_hsa041460.75856741
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75241871
55Fatty acid metabolism_Homo sapiens_hsa012120.73971519
56N-Glycan biosynthesis_Homo sapiens_hsa005100.73489970
57Butanoate metabolism_Homo sapiens_hsa006500.70172435
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.67545321
59Metabolic pathways_Homo sapiens_hsa011000.62390307
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60766149
61Regulation of autophagy_Homo sapiens_hsa041400.59360688
62Pentose phosphate pathway_Homo sapiens_hsa000300.58344680
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57954438
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56645231
65TGF-beta signaling pathway_Homo sapiens_hsa043500.56636121
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56376461
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55986402
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53221788
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51878099
70Fatty acid degradation_Homo sapiens_hsa000710.51613903
71beta-Alanine metabolism_Homo sapiens_hsa004100.47341588
72Thyroid cancer_Homo sapiens_hsa052160.43566633
73Hippo signaling pathway_Homo sapiens_hsa043900.41889698
74Arginine and proline metabolism_Homo sapiens_hsa003300.41126121
75Adherens junction_Homo sapiens_hsa045200.40737239
76Alzheimers disease_Homo sapiens_hsa050100.40000084
77Circadian rhythm_Homo sapiens_hsa047100.39420356
78Epstein-Barr virus infection_Homo sapiens_hsa051690.38318319
79Lysine degradation_Homo sapiens_hsa003100.37052557
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34950351
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31596618
82Tryptophan metabolism_Homo sapiens_hsa003800.24817977
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.23462427
84Sphingolipid metabolism_Homo sapiens_hsa006000.22954725
85Phototransduction_Homo sapiens_hsa047440.22385951
86Collecting duct acid secretion_Homo sapiens_hsa049660.21717589
87Legionellosis_Homo sapiens_hsa051340.21325827
88Wnt signaling pathway_Homo sapiens_hsa043100.19665981
89Nitrogen metabolism_Homo sapiens_hsa009100.18182693
90Viral carcinogenesis_Homo sapiens_hsa052030.17612775
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17386176
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16452972
93Colorectal cancer_Homo sapiens_hsa052100.11211857
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10199336
95Tyrosine metabolism_Homo sapiens_hsa003500.09646311
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.09407570
97MicroRNAs in cancer_Homo sapiens_hsa052060.08707167
98Retinol metabolism_Homo sapiens_hsa008300.08006327
99Tight junction_Homo sapiens_hsa045300.06671736
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06538696

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