C5ORF24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)3.15946767
2axonal fasciculation (GO:0007413)2.99505943
3paraxial mesoderm development (GO:0048339)2.89080557
4neuron recognition (GO:0008038)2.79774738
5postsynaptic membrane organization (GO:0001941)2.75992503
6collagen fibril organization (GO:0030199)2.75768819
7chondrocyte proliferation (GO:0035988)2.64413850
8regulation of axon extension involved in axon guidance (GO:0048841)2.62346428
9protein localization to synapse (GO:0035418)2.62011497
10glutamate secretion (GO:0014047)2.58754577
11positive regulation of mitochondrial fission (GO:0090141)2.58484472
12regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.57644939
13retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57258475
14presynaptic membrane assembly (GO:0097105)2.56902127
15axon extension (GO:0048675)2.55769880
16embryonic retina morphogenesis in camera-type eye (GO:0060059)2.53426278
17kidney mesenchyme development (GO:0072074)2.52497116
18lens morphogenesis in camera-type eye (GO:0002089)2.43169549
19neural crest cell development (GO:0014032)2.42351489
20regulation of axon guidance (GO:1902667)2.42217840
21basement membrane organization (GO:0071711)2.41837432
22dendrite morphogenesis (GO:0048813)2.37411616
23ectodermal placode formation (GO:0060788)2.35642835
24embryonic foregut morphogenesis (GO:0048617)2.32200531
25neurotransmitter-gated ion channel clustering (GO:0072578)2.32143364
26lymphangiogenesis (GO:0001946)2.31841362
27neuron cell-cell adhesion (GO:0007158)2.31522019
28synaptic vesicle docking involved in exocytosis (GO:0016081)2.31295917
29morphogenesis of an epithelial sheet (GO:0002011)2.27967790
30metanephric mesenchyme development (GO:0072075)2.27301303
31presynaptic membrane organization (GO:0097090)2.26797624
32regulation of short-term neuronal synaptic plasticity (GO:0048172)2.23687407
33negative regulation of axon extension involved in axon guidance (GO:0048843)2.23375415
34calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.22908174
35regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.21794553
36layer formation in cerebral cortex (GO:0021819)2.21630928
37cerebral cortex radially oriented cell migration (GO:0021799)2.21162472
38central nervous system projection neuron axonogenesis (GO:0021952)2.18727427
39establishment of nucleus localization (GO:0040023)2.17733845
40negative regulation of chondrocyte differentiation (GO:0032331)2.16615942
41membrane assembly (GO:0071709)2.13924760
42positive regulation of synapse assembly (GO:0051965)2.13500585
43pyrimidine nucleobase catabolic process (GO:0006208)2.13306528
44sequestering of extracellular ligand from receptor (GO:0035581)2.13085064
45hippo signaling (GO:0035329)2.12931596
46regulation of cAMP-dependent protein kinase activity (GO:2000479)2.12832452
47negative chemotaxis (GO:0050919)2.10572073
48ganglion development (GO:0061548)2.10042630
49apical protein localization (GO:0045176)2.09657315
50cranial nerve morphogenesis (GO:0021602)2.08201117
51vascular smooth muscle contraction (GO:0014829)2.08158976
52chondrocyte development (GO:0002063)2.07653525
53positive regulation of dendritic spine morphogenesis (GO:0061003)2.07318277
54neuron projection extension (GO:1990138)2.07030824
55regulation of cardioblast proliferation (GO:0003264)2.05672714
56regulation of secondary heart field cardioblast proliferation (GO:0003266)2.05672714
57endodermal cell differentiation (GO:0035987)2.05399309
58asymmetric protein localization (GO:0008105)2.05219390
59neuron projection extension involved in neuron projection guidance (GO:1902284)2.05021706
60axon extension involved in axon guidance (GO:0048846)2.05021706
61suckling behavior (GO:0001967)2.04896488
62endocardial cushion morphogenesis (GO:0003203)2.04782448
63regulation of synapse assembly (GO:0051963)2.04733866
64endocardial cushion development (GO:0003197)2.04700372
65cell migration in hindbrain (GO:0021535)2.04484594
66cytoplasmic mRNA processing body assembly (GO:0033962)2.03460932
67wound healing, spreading of epidermal cells (GO:0035313)2.03120447
68regulation of synapse structural plasticity (GO:0051823)1.99903763
69G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.99643508
70negative regulation of axon guidance (GO:1902668)1.99353236
71mesenchyme morphogenesis (GO:0072132)1.99020121
72regulation of heart morphogenesis (GO:2000826)1.98461182
73atrial septum morphogenesis (GO:0060413)1.98090428
74mesenchymal cell development (GO:0014031)1.97993667
75response to gravity (GO:0009629)1.97842082
76polarized epithelial cell differentiation (GO:0030859)1.96439102
77COPII vesicle coating (GO:0048208)1.96269320
78dendritic spine morphogenesis (GO:0060997)1.95911315
79myoblast fusion (GO:0007520)1.95629909
80neuronal stem cell maintenance (GO:0097150)1.95031020
81regulation of dendritic spine morphogenesis (GO:0061001)1.94951873
82smooth muscle tissue development (GO:0048745)1.94938309
83cell communication by electrical coupling (GO:0010644)1.91664618
84regulation of Rac protein signal transduction (GO:0035020)1.91208311
85COPI coating of Golgi vesicle (GO:0048205)1.91190647
86Golgi transport vesicle coating (GO:0048200)1.91190647
87endoplasmic reticulum organization (GO:0007029)1.91056050
88regulation of cell proliferation involved in heart morphogenesis (GO:2000136)1.90964612
89camera-type eye morphogenesis (GO:0048593)1.90501581
90negative regulation of catenin import into nucleus (GO:0035414)1.89177673
91Wnt signaling pathway, planar cell polarity pathway (GO:0060071)1.88946341
92regulation of establishment of planar polarity (GO:0090175)1.88852316
93ventricular septum morphogenesis (GO:0060412)1.88604384
94regulation of cardioblast differentiation (GO:0051890)1.88106666
95cerebral cortex cell migration (GO:0021795)1.87222145
96positive regulation of dendritic spine development (GO:0060999)1.86745552
97peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)1.86702240
98protein retention in ER lumen (GO:0006621)1.86539606
99astrocyte development (GO:0014002)1.85949874
100mesodermal cell differentiation (GO:0048333)1.85225135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.42780890
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.20485024
3WT1_19549856_ChIP-ChIP_CCG9911_Human2.78777957
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.32307153
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28939119
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26951906
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.16449629
8GBX2_23144817_ChIP-Seq_PC3_Human2.15019517
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12728183
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11802529
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10057179
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.05940425
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.02150805
14FUS_26573619_Chip-Seq_HEK293_Human1.99839976
15PIAS1_25552417_ChIP-Seq_VCAP_Human1.98502951
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98135087
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95247613
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95247613
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.94447205
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86677954
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85105978
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84498470
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83826008
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83400619
25TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.82400057
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81497369
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.80825876
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74831031
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74508169
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73819294
31TAF15_26573619_Chip-Seq_HEK293_Human1.66639367
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66096176
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64702732
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.62450559
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.62450559
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61824985
37EZH2_22144423_ChIP-Seq_EOC_Human1.61353185
38TP53_18474530_ChIP-ChIP_U2OS_Human1.59194594
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57913777
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56343166
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55760064
42RNF2_27304074_Chip-Seq_NSC_Mouse1.55460084
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52947693
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52056689
45IGF1R_20145208_ChIP-Seq_DFB_Human1.49023955
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.48884863
47CJUN_26792858_Chip-Seq_BT549_Human1.45254483
48YAP1_20516196_ChIP-Seq_MESCs_Mouse1.43083231
49SMAD4_21799915_ChIP-Seq_A2780_Human1.42860169
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41717814
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41613138
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41350359
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40768170
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40234090
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.33806404
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33531047
57MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33264018
58TP53_16413492_ChIP-PET_HCT116_Human1.32404040
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31585433
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31440892
61EWS_26573619_Chip-Seq_HEK293_Human1.31015592
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.30208376
63BRD4_25478319_ChIP-Seq_HGPS_Human1.29311352
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.27333885
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.27268406
66SOX9_26525672_Chip-Seq_HEART_Mouse1.25589489
67STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25492440
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.23699453
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22754704
70TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21110761
71TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20671109
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19603872
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.18595737
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18043404
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18026021
76CLOCK_20551151_ChIP-Seq_293T_Human1.17852144
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17346340
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16941208
79P300_19829295_ChIP-Seq_ESCs_Human1.16669650
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.14604866
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14031391
82AR_21909140_ChIP-Seq_LNCAP_Human1.12890024
83SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12498968
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11768608
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11452929
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09919445
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07966513
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07920916
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07335425
90TP53_20018659_ChIP-ChIP_R1E_Mouse1.06942616
91AHR_22903824_ChIP-Seq_MCF-7_Human1.06928373
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06344254
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06153737
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05038631
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.04338771
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03860363
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.03716162
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02738836
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.00995989
100STAT3_23295773_ChIP-Seq_U87_Human1.00889377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.53998362
2MP0004272_abnormal_basement_membrane2.65347631
3MP0009780_abnormal_chondrocyte_physiolo2.50135541
4MP0005623_abnormal_meninges_morphology2.39381181
5MP0000534_abnormal_ureter_morphology1.95087362
6MP0003385_abnormal_body_wall1.92674926
7MP0005503_abnormal_tendon_morphology1.89087511
8MP0001299_abnormal_eye_distance/1.86666535
9MP0005187_abnormal_penis_morphology1.84651987
10MP0010368_abnormal_lymphatic_system1.82710130
11MP0005275_abnormal_skin_tensile1.79983950
12MP0003705_abnormal_hypodermis_morpholog1.79215131
13MP0003942_abnormal_urinary_system1.75025431
14MP0003122_maternal_imprinting1.74929239
15MP0005171_absent_coat_pigmentation1.73025932
16MP0000778_abnormal_nervous_system1.68774678
17MP0000013_abnormal_adipose_tissue1.61858822
18MP0002009_preneoplasia1.57025156
19MP0004859_abnormal_synaptic_plasticity1.56102158
20MP0004270_analgesia1.47452359
21MP0005409_darkened_coat_color1.44101685
22MP0003279_aneurysm1.43842602
23MP0009384_cardiac_valve_regurgitation1.43047325
24MP0001879_abnormal_lymphatic_vessel1.40272967
25MP0001958_emphysema1.40059210
26MP0005257_abnormal_intraocular_pressure1.39669215
27MP0000569_abnormal_digit_pigmentation1.36606291
28MP0009053_abnormal_anal_canal1.36453716
29MP0003283_abnormal_digestive_organ1.33044161
30MP0009250_abnormal_appendicular_skeleto1.31915389
31MP0003880_abnormal_central_pattern1.31106316
32MP0002877_abnormal_melanocyte_morpholog1.29660636
33MP0000751_myopathy1.29540072
34MP0003941_abnormal_skin_development1.28235534
35MP0003755_abnormal_palate_morphology1.27040643
36MP0002697_abnormal_eye_size1.25625879
37MP0003121_genomic_imprinting1.24028967
38MP0003566_abnormal_cell_adhesion1.23573544
39MP0000767_abnormal_smooth_muscle1.22807132
40MP0004134_abnormal_chest_morphology1.21518915
41MP0000537_abnormal_urethra_morphology1.19252605
42MP0002234_abnormal_pharynx_morphology1.14618022
43MP0003935_abnormal_craniofacial_develop1.13629708
44MP0003937_abnormal_limbs/digits/tail_de1.09826321
45MP0000462_abnormal_digestive_system1.09233451
46MP0005423_abnormal_somatic_nervous1.09069082
47MP0003890_abnormal_embryonic-extraembry1.08557489
48MP0000733_abnormal_muscle_development1.06383898
49MP0000762_abnormal_tongue_morphology1.05396132
50MP0000566_synostosis1.05091783
51MP0002896_abnormal_bone_mineralization1.02983626
52MP0003091_abnormal_cell_migration1.02753073
53MP0003950_abnormal_plasma_membrane1.02706588
54MP0000955_abnormal_spinal_cord1.01131075
55MP0002184_abnormal_innervation1.00750623
56MP0010352_gastrointestinal_tract_polyps0.99211704
57MP0002751_abnormal_autonomic_nervous0.98025932
58MP0002092_abnormal_eye_morphology0.96374752
59MP0002938_white_spotting0.94247728
60MP0001286_abnormal_eye_development0.94223266
61MP0002108_abnormal_muscle_morphology0.93930230
62MP0009697_abnormal_copulation0.93802494
63MP0010030_abnormal_orbit_morphology0.92535107
64MP0004084_abnormal_cardiac_muscle0.92364559
65MP0006276_abnormal_autonomic_nervous0.91906604
66MP0003635_abnormal_synaptic_transmissio0.91350951
67MP0000049_abnormal_middle_ear0.91253876
68MP0000428_abnormal_craniofacial_morphol0.90384103
69MP0006138_congestive_heart_failure0.89823555
70MP0003123_paternal_imprinting0.88721357
71MP0002233_abnormal_nose_morphology0.88294843
72MP0005197_abnormal_uvea_morphology0.87385742
73MP0002116_abnormal_craniofacial_bone0.86669433
74MP0003115_abnormal_respiratory_system0.86606696
75MP0005508_abnormal_skeleton_morphology0.85668773
76MP0003861_abnormal_nervous_system0.84494106
77MP0002063_abnormal_learning/memory/cond0.83784927
78MP0004215_abnormal_myocardial_fiber0.83366651
79MP0002081_perinatal_lethality0.82567454
80MP0005248_abnormal_Harderian_gland0.79508556
81MP0002932_abnormal_joint_morphology0.78472926
82MP0001270_distended_abdomen0.78196557
83MP0003787_abnormal_imprinting0.77985818
84MP0001177_atelectasis0.77651967
85MP0002114_abnormal_axial_skeleton0.76249264
86MP0004811_abnormal_neuron_physiology0.75772035
87MP0000432_abnormal_head_morphology0.75278664
88MP0002084_abnormal_developmental_patter0.75008281
89MP0004858_abnormal_nervous_system0.73531054
90MP0000003_abnormal_adipose_tissue0.72323975
91MP0008775_abnormal_heart_ventricle0.71473599
92MP0000749_muscle_degeneration0.71351483
93MP0001943_abnormal_respiration0.71104047
94MP0003119_abnormal_digestive_system0.70761581
95MP0002734_abnormal_mechanical_nocicepti0.69527154
96MP0002152_abnormal_brain_morphology0.69321918
97MP0002109_abnormal_limb_morphology0.69156834
98MP0004924_abnormal_behavior0.68645696
99MP0005386_behavior/neurological_phenoty0.68645696
100MP0000163_abnormal_cartilage_morphology0.68493608

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.14888395
2Protrusio acetabuli (HP:0003179)3.68260094
3Arterial tortuosity (HP:0005116)3.07528580
4Aortic dissection (HP:0002647)2.98311262
5Vascular tortuosity (HP:0004948)2.84628010
6Bladder diverticulum (HP:0000015)2.83303681
7Soft skin (HP:0000977)2.49168989
8Atrophic scars (HP:0001075)2.42488962
9Aortic aneurysm (HP:0004942)2.28230610
10Shallow orbits (HP:0000586)2.27699118
11Overgrowth (HP:0001548)2.25525465
12Vertebral arch anomaly (HP:0008438)2.24416306
13Abnormality of dentin (HP:0010299)2.24198106
14Bowel diverticulosis (HP:0005222)2.20286145
15Papillary thyroid carcinoma (HP:0002895)2.12126024
16Insomnia (HP:0100785)2.10011443
17Hyperventilation (HP:0002883)2.06403106
18Coronal craniosynostosis (HP:0004440)2.05076593
19Pheochromocytoma (HP:0002666)2.04393073
20Renal duplication (HP:0000075)2.00727848
21Mitral valve prolapse (HP:0001634)1.99573147
22Neonatal short-limb short stature (HP:0008921)1.99523935
23Wide anterior fontanel (HP:0000260)1.97306429
24Hyperextensible skin (HP:0000974)1.95111316
25Ankle contracture (HP:0006466)1.89787039
26Wormian bones (HP:0002645)1.89187034
27Renovascular hypertension (HP:0100817)1.88967009
28Follicular hyperkeratosis (HP:0007502)1.81412322
29Drooling (HP:0002307)1.78569110
30Spinal rigidity (HP:0003306)1.78154340
31Mitral stenosis (HP:0001718)1.77745115
32Hyperacusis (HP:0010780)1.74551207
33Termporal pattern (HP:0011008)1.73933133
34Insidious onset (HP:0003587)1.73933133
35Elfin facies (HP:0004428)1.72679372
36Fragile skin (HP:0001030)1.69372309
37Broad palm (HP:0001169)1.68708168
38Syringomyelia (HP:0003396)1.68704237
39Spinal cord lesions (HP:0100561)1.68704237
40Pulmonic stenosis (HP:0001642)1.68143122
41Large earlobe (HP:0009748)1.65531866
42Cerebral aneurysm (HP:0004944)1.65428748
43Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.63566016
44Midline defect of the nose (HP:0004122)1.63334609
45Morphological abnormality of the middle ear (HP:0008609)1.62795725
46Abnormality of the lower motor neuron (HP:0002366)1.61710539
47Neoplasm of the heart (HP:0100544)1.61375239
48Limited hip movement (HP:0008800)1.60105124
49Broad metatarsal (HP:0001783)1.58867474
50Abnormality of the corticospinal tract (HP:0002492)1.58070662
51Flat cornea (HP:0007720)1.56411195
52Turricephaly (HP:0000262)1.56188844
53Thyroid carcinoma (HP:0002890)1.56083256
54Abnormality of the ischium (HP:0003174)1.55085546
55Asymmetry of the thorax (HP:0001555)1.55019208
56Metatarsus adductus (HP:0001840)1.54815556
57Mildly elevated creatine phosphokinase (HP:0008180)1.52686235
58Neuroendocrine neoplasm (HP:0100634)1.52106955
59Hypoventilation (HP:0002791)1.51625558
60Overriding aorta (HP:0002623)1.51582277
61Calcaneovalgus deformity (HP:0001848)1.51464737
62Ulnar bowing (HP:0003031)1.51295667
63Hypoplasia of the iris (HP:0007676)1.51027387
64Abnormality of the phalanges of the hallux (HP:0010057)1.50187608
65Exotropia (HP:0000577)1.50079359
66Cubitus valgus (HP:0002967)1.49699135
67Type 1 muscle fiber predominance (HP:0003803)1.49264840
68Cutaneous finger syndactyly (HP:0010554)1.47887356
69Hammertoe (HP:0001765)1.47163530
70Mitral regurgitation (HP:0001653)1.46848448
71Excessive salivation (HP:0003781)1.46121663
72Infantile muscular hypotonia (HP:0008947)1.44131761
73Hallux valgus (HP:0001822)1.43099091
74Aplasia involving bones of the extremities (HP:0009825)1.42729833
75Aplasia involving bones of the upper limbs (HP:0009823)1.42729833
76Aplasia of the phalanges of the hand (HP:0009802)1.42729833
77Abnormality of the calcaneus (HP:0008364)1.42156302
78Buphthalmos (HP:0000557)1.41796995
79Deviation of the hallux (HP:0010051)1.41321745
80Joint laxity (HP:0001388)1.40447627
81Relative macrocephaly (HP:0004482)1.40135213
82Arnold-Chiari malformation (HP:0002308)1.38824463
83Limb-girdle muscle weakness (HP:0003325)1.38743267
84Venous insufficiency (HP:0005293)1.38437464
85Shawl scrotum (HP:0000049)1.37855642
86Protruding ear (HP:0000411)1.37487013
87Deformed tarsal bones (HP:0008119)1.37389129
88Pulmonary artery stenosis (HP:0004415)1.36878075
89Atonic seizures (HP:0010819)1.35616680
90Abnormality of the acetabulum (HP:0003170)1.34153572
91Open mouth (HP:0000194)1.33991571
92Round ear (HP:0100830)1.33532376
93Mild short stature (HP:0003502)1.33496190
94Genu recurvatum (HP:0002816)1.33227047
95Knee flexion contracture (HP:0006380)1.33050588
96Abnormality of the diencephalon (HP:0010662)1.32935763
97Sacral dimple (HP:0000960)1.32562668
98Hand muscle atrophy (HP:0009130)1.31870205
99Inguinal hernia (HP:0000023)1.31816910
100Limb-girdle muscle atrophy (HP:0003797)1.31440971

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.45976256
2PNCK2.59524919
3PDGFRA2.54757122
4CASK2.32952104
5ERBB32.31588256
6NTRK12.30197407
7BCR2.26417783
8LATS22.24192592
9LATS12.02006302
10LIMK11.83097427
11AKT31.74133455
12MAP3K41.70445386
13EPHB21.60016343
14PTK21.53473237
15STK38L1.45659141
16PAK21.44572142
17EPHA41.41941052
18STK391.41089405
19DMPK1.39770486
20NTRK21.37118102
21PRKD31.34915970
22TIE11.32061864
23MAP2K71.26548490
24NEK91.26358698
25CSNK1A1L1.25972423
26NTRK31.20848484
27DDR21.19772157
28WNK41.18717412
29MET1.18357427
30CAMK1G1.16422730
31WNK11.10839470
32UHMK11.09784049
33PAK31.09555072
34PLK21.05865554
35CSNK1G21.03204864
36ERBB41.02390900
37MYLK0.99864520
38FER0.97052177
39CSNK1G10.96751529
40CAMKK20.95686370
41DYRK1B0.95503689
42WNK30.93982013
43CDK80.93704873
44BRD40.93560815
45PAK60.93551804
46PDGFRB0.91567865
47PIK3CA0.91337790
48ICK0.91225602
49CSNK1G30.88883050
50SCYL20.87326787
51SGK20.85638330
52KSR10.82052189
53SGK4940.80990511
54SGK2230.80990511
55TTN0.77113441
56STK30.75470304
57FGFR20.75365088
58PHKG20.74860327
59PHKG10.74860327
60PRKCE0.74414245
61MINK10.74370658
62TESK10.74285935
63EPHA30.72681599
64SGK30.69679850
65BRSK10.68588063
66BRSK20.68077993
67PKN20.63403464
68FGFR10.62994475
69MAP2K40.62757803
70CDK180.60263799
71MTOR0.59107825
72ROCK20.58516036
73CDK150.58062292
74TSSK60.57749219
75CDK140.56922302
76NEK10.56665188
77MKNK20.56458666
78CAMK1D0.56337259
79RIPK10.55778000
80PRKCG0.55578865
81CDK50.54582286
82MAPK130.53947274
83LMTK20.53944750
84SIK10.52830226
85MOS0.52611095
86CDK11A0.52431805
87CDK60.51307981
88CDK30.49215335
89ROCK10.48978039
90CAMK2B0.47780332
91MAP3K90.47249213
92MKNK10.47245508
93STK380.46645461
94PINK10.46635013
95CSNK1E0.45576328
96GSK3A0.45464725
97DYRK30.43661317
98TYRO30.42616767
99PRKAA10.42285758
100MAPK150.42222497

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.05574123
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90287388
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.87936262
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.82562844
5Hippo signaling pathway_Homo sapiens_hsa043901.78776139
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.61871076
7Dilated cardiomyopathy_Homo sapiens_hsa054141.60379627
8Focal adhesion_Homo sapiens_hsa045101.55664680
9Adherens junction_Homo sapiens_hsa045201.48640692
10TGF-beta signaling pathway_Homo sapiens_hsa043501.48040877
11Axon guidance_Homo sapiens_hsa043601.46072585
12Hedgehog signaling pathway_Homo sapiens_hsa043401.41475781
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39924307
14Dopaminergic synapse_Homo sapiens_hsa047281.38326472
15Cocaine addiction_Homo sapiens_hsa050301.34463124
16Glutamatergic synapse_Homo sapiens_hsa047241.26894722
17Nicotine addiction_Homo sapiens_hsa050331.24157411
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17991621
19GABAergic synapse_Homo sapiens_hsa047271.14992934
20Circadian rhythm_Homo sapiens_hsa047101.14485579
21Amphetamine addiction_Homo sapiens_hsa050311.14303250
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14266586
23Basal cell carcinoma_Homo sapiens_hsa052171.13931036
24Prion diseases_Homo sapiens_hsa050201.04902008
25Circadian entrainment_Homo sapiens_hsa047131.03820460
26Melanogenesis_Homo sapiens_hsa049161.03295002
27Insulin secretion_Homo sapiens_hsa049111.02823157
28Small cell lung cancer_Homo sapiens_hsa052221.02758754
29Proteoglycans in cancer_Homo sapiens_hsa052051.02068580
30Gap junction_Homo sapiens_hsa045401.01572748
31Tight junction_Homo sapiens_hsa045301.01350083
32Wnt signaling pathway_Homo sapiens_hsa043101.01330368
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01079635
34Protein digestion and absorption_Homo sapiens_hsa049741.00741492
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99475539
36Steroid biosynthesis_Homo sapiens_hsa001000.99184315
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99110321
38Glioma_Homo sapiens_hsa052140.98988524
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98576703
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96910821
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96824150
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94580779
43MicroRNAs in cancer_Homo sapiens_hsa052060.92371896
44AMPK signaling pathway_Homo sapiens_hsa041520.92144411
45Renin secretion_Homo sapiens_hsa049240.91816384
46Long-term potentiation_Homo sapiens_hsa047200.90450227
47Thyroid hormone synthesis_Homo sapiens_hsa049180.89664016
48Melanoma_Homo sapiens_hsa052180.89375964
49PI3K-Akt signaling pathway_Homo sapiens_hsa041510.88605354
50Endometrial cancer_Homo sapiens_hsa052130.87392917
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86618226
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86312825
53Propanoate metabolism_Homo sapiens_hsa006400.84747403
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84676278
55Renal cell carcinoma_Homo sapiens_hsa052110.84185510
56Fatty acid biosynthesis_Homo sapiens_hsa000610.84010683
57Long-term depression_Homo sapiens_hsa047300.81587840
58Estrogen signaling pathway_Homo sapiens_hsa049150.81426584
59ErbB signaling pathway_Homo sapiens_hsa040120.78001663
60Thyroid cancer_Homo sapiens_hsa052160.75361732
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74307402
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74195384
63Cholinergic synapse_Homo sapiens_hsa047250.73722461
64Colorectal cancer_Homo sapiens_hsa052100.73464859
65cAMP signaling pathway_Homo sapiens_hsa040240.73394931
66Pathways in cancer_Homo sapiens_hsa052000.72607688
67Lysine degradation_Homo sapiens_hsa003100.72543909
68Glucagon signaling pathway_Homo sapiens_hsa049220.72394044
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71483780
70Synaptic vesicle cycle_Homo sapiens_hsa047210.71351213
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68895420
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68679339
73Morphine addiction_Homo sapiens_hsa050320.67688696
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67531917
75Protein export_Homo sapiens_hsa030600.66066173
76Chronic myeloid leukemia_Homo sapiens_hsa052200.65952064
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65016997
78Oxytocin signaling pathway_Homo sapiens_hsa049210.65016336
79Amoebiasis_Homo sapiens_hsa051460.64859252
80Bile secretion_Homo sapiens_hsa049760.64518207
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62847681
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.62631545
83Choline metabolism in cancer_Homo sapiens_hsa052310.61706173
84Vitamin B6 metabolism_Homo sapiens_hsa007500.60587073
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.59703555
86Vibrio cholerae infection_Homo sapiens_hsa051100.59474141
87mTOR signaling pathway_Homo sapiens_hsa041500.59309281
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.59247216
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.59070057
90Fatty acid metabolism_Homo sapiens_hsa012120.58306083
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57677947
92Rap1 signaling pathway_Homo sapiens_hsa040150.56738731
93mRNA surveillance pathway_Homo sapiens_hsa030150.56121794
94Insulin signaling pathway_Homo sapiens_hsa049100.55670533
95Taste transduction_Homo sapiens_hsa047420.55641541
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54872236
97Ras signaling pathway_Homo sapiens_hsa040140.54632511
98Gastric acid secretion_Homo sapiens_hsa049710.54349357
99Bladder cancer_Homo sapiens_hsa052190.54332850
100Serotonergic synapse_Homo sapiens_hsa047260.54312790

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