ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	presynaptic membrane assembly (GO:0097105)	3.70522898
2	pyrimidine nucleobase catabolic process (GO:0006208)	3.68516571
3	regulation of development, heterochronic (GO:0040034)	3.41404379
4	DNA double-strand break processing (GO:0000729)	3.35166718
5	cerebral cortex radially oriented cell migration (GO:0021799)	3.30470844
6	cholesterol biosynthetic process (GO:0006695)	3.25807046
7	layer formation in cerebral cortex (GO:0021819)	3.22499178
8	presynaptic membrane organization (GO:0097090)	3.19590520
9	postsynaptic membrane organization (GO:0001941)	3.07807405
10	glutamate secretion (GO:0014047)	3.04786892
11	regulation of timing of cell differentiation (GO:0048505)	3.03909729
12	sequestering of actin monomers (GO:0042989)	2.99499419
13	neuron cell-cell adhesion (GO:0007158)	2.95427540
14	establishment of mitochondrion localization (GO:0051654)	2.91374203
15	sterol biosynthetic process (GO:0016126)	2.90728056
16	olfactory bulb development (GO:0021772)	2.89974585
17	nucleobase catabolic process (GO:0046113)	2.89533933
18	positive regulation of synapse assembly (GO:0051965)	2.86721571
19	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.84533404
20	central nervous system projection neuron axonogenesis (GO:0021952)	2.81027157
21	peptidyl-cysteine modification (GO:0018198)	2.77947027
22	DNA ligation (GO:0006266)	2.75908486
23	isoprenoid biosynthetic process (GO:0008299)	2.73117933
24	axonal fasciculation (GO:0007413)	2.72566978
25	microtubule depolymerization (GO:0007019)	2.67295926
26	lens morphogenesis in camera-type eye (GO:0002089)	2.66900761
27	cerebral cortex neuron differentiation (GO:0021895)	2.64774963
28	protein localization to synapse (GO:0035418)	2.64045224
29	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.63110565
30	synaptic vesicle endocytosis (GO:0048488)	2.60884671
31	limb bud formation (GO:0060174)	2.57071954
32	C4-dicarboxylate transport (GO:0015740)	2.55257703
33	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.53737586
34	spinal cord association neuron differentiation (GO:0021527)	2.53553861
35	CENP-A containing nucleosome assembly (GO:0034080)	2.51111819
36	neuron recognition (GO:0008038)	2.50949919
37	cerebral cortex cell migration (GO:0021795)	2.48905487
38	regulation of penile erection (GO:0060405)	2.46868525
39	sympathetic nervous system development (GO:0048485)	2.46006267
40	glial cell proliferation (GO:0014009)	2.45104486
41	negative regulation of DNA recombination (GO:0045910)	2.43972430
42	chromatin remodeling at centromere (GO:0031055)	2.42929303
43	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.42914545
44	cullin deneddylation (GO:0010388)	2.40297555
45	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.37663348
46	positive regulation of mitochondrial fission (GO:0090141)	2.35579828
47	generation of neurons (GO:0048699)	2.31264066
48	synaptic vesicle maturation (GO:0016188)	2.31031367
49	hippocampus development (GO:0021766)	2.30008892
50	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.29881478
51	forebrain neuron differentiation (GO:0021879)	2.29103499
52	regulation of synaptic vesicle exocytosis (GO:2000300)	2.28126563
53	vocalization behavior (GO:0071625)	2.27910246
54	microtubule polymerization or depolymerization (GO:0031109)	2.27763499
55	regulation of synapse assembly (GO:0051963)	2.25192761
56	regulation of respiratory system process (GO:0044065)	2.24926726
57	synaptic vesicle exocytosis (GO:0016079)	2.23428142
58	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.22474234
59	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.20937866
60	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.19839466
61	lipopolysaccharide biosynthetic process (GO:0009103)	2.19658727
62	negative regulation of glial cell differentiation (GO:0045686)	2.19203570
63	fatty acid elongation (GO:0030497)	2.18619023
64	neuronal action potential propagation (GO:0019227)	2.18113754
65	aggressive behavior (GO:0002118)	2.18009184
66	central nervous system neuron axonogenesis (GO:0021955)	2.17377937
67	glycosphingolipid biosynthetic process (GO:0006688)	2.17130044
68	protein deneddylation (GO:0000338)	2.16797232
69	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.16526911
70	negative regulation of microtubule polymerization (GO:0031115)	2.16037190
71	synapse assembly (GO:0007416)	2.10961616
72	mitotic spindle organization (GO:0007052)	2.10615973
73	DNA damage response, detection of DNA damage (GO:0042769)	2.09836721
74	ubiquinone metabolic process (GO:0006743)	2.09768782
75	retinal rod cell development (GO:0046548)	2.09079108
76	postreplication repair (GO:0006301)	2.08846890
77	acidic amino acid transport (GO:0015800)	2.07598807
78	behavioral fear response (GO:0001662)	2.07423733
79	behavioral defense response (GO:0002209)	2.07423733
80	regulation of helicase activity (GO:0051095)	2.07081950
81	fibroblast migration (GO:0010761)	2.05432050
82	negative regulation of astrocyte differentiation (GO:0048712)	2.05200953
83	histone exchange (GO:0043486)	2.04656597
84	deoxyribonucleotide biosynthetic process (GO:0009263)	2.03702620
85	neuron fate commitment (GO:0048663)	2.03054348
86	L-serine metabolic process (GO:0006563)	2.02958993
87	peptidyl-arginine N-methylation (GO:0035246)	2.02151272
88	peptidyl-arginine methylation (GO:0018216)	2.02151272
89	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.01048103
90	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.01048103
91	intraciliary transport (GO:0042073)	2.00965239
92	histone H2A acetylation (GO:0043968)	2.00512446
93	spermatid nucleus differentiation (GO:0007289)	2.00506518
94	DNA topological change (GO:0006265)	1.98925448
95	regulation of dendritic spine morphogenesis (GO:0061001)	1.98237161
96	response to auditory stimulus (GO:0010996)	1.98145005
97	regulation of synaptic transmission, GABAergic (GO:0032228)	1.97100575
98	DNA replication-dependent nucleosome assembly (GO:0006335)	1.96298607
99	DNA replication-dependent nucleosome organization (GO:0034723)	1.96298607
100	protein neddylation (GO:0045116)	1.96183848

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.99211922
2	GBX2_23144817_ChIP-Seq_PC3_Human	2.81139963
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.74992485
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.70277087
5	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.59262636
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.46771530
7	* POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.45553187
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37458558
9	EWS_26573619_Chip-Seq_HEK293_Human	2.27966248
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.22992040
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.20876578
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.17613229
13	FUS_26573619_Chip-Seq_HEK293_Human	2.07642840
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.04753123
15	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.99078640
16	ELK1_19687146_ChIP-ChIP_HELA_Human	1.93950722
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.88537405
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.83301881
19	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.82663833
20	P300_19829295_ChIP-Seq_ESCs_Human	1.76815343
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.73991654
22	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.66793255
23	EZH2_22144423_ChIP-Seq_EOC_Human	1.64089524
24	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62421808
25	* PIAS1_25552417_ChIP-Seq_VCAP_Human	1.61739264
26	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.61698181
27	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.59425182
28	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.58775530
29	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.57017508
30	AR_21909140_ChIP-Seq_LNCAP_Human	1.55968376
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.53385903
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.52011845
33	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47658409
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.45787362
35	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.44829482
36	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.44098459
37	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.43525242
38	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40203798
39	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.38499559
40	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35560520
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.34832281
42	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.32829966
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.31826316
44	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.29698557
45	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28720441
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28546386
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27816309
48	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.27710247
49	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.24661582
50	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.23600917
51	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.22509749
52	* JUN_21703547_ChIP-Seq_K562_Human	1.21594754
53	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.20604909
54	SOX9_26525672_Chip-Seq_HEART_Mouse	1.20577845
55	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.18552009
56	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.17731954
57	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.15877522
58	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15196951
59	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.15027392
60	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14547226
61	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12783718
62	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.12317351
63	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.12030432
64	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.10422746
65	MYC_18940864_ChIP-ChIP_HL60_Human	1.09863195
66	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.09487418
67	E2F7_22180533_ChIP-Seq_HELA_Human	1.09436899
68	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.09406414
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.09166682
70	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.08941428
71	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.08941428
72	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.08761587
73	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.06010174
74	VDR_22108803_ChIP-Seq_LS180_Human	1.04138798
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.03704125
76	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.03074698
77	TP53_18474530_ChIP-ChIP_U2OS_Human	1.02685432
78	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.02106916
79	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.02039973
80	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.01793217
81	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.01762428
82	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01356754
83	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.99728828
84	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99452473
85	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.99314032
86	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.99254608
87	CBP_20019798_ChIP-Seq_JUKART_Human	0.99254608
88	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.96979366
89	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.96857808
90	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.96463426
91	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.96032074
92	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95581893
93	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.95323047
94	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.95252851
95	DCP1A_22483619_ChIP-Seq_HELA_Human	0.94915119
96	STAT3_23295773_ChIP-Seq_U87_Human	0.94893662
97	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.94201559
98	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.93606317
99	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.93102637
100	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.93085840

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	3.01515430
2	MP0001529_abnormal_vocalization	3.00219335
3	MP0005171_absent_coat_pigmentation	2.42325417
4	MP0003880_abnormal_central_pattern	2.31051454
5	MP0004270_analgesia	2.28767545
6	MP0000778_abnormal_nervous_system	2.13631351
7	MP0008789_abnormal_olfactory_epithelium	2.01247663
8	MP0002653_abnormal_ependyma_morphology	1.87719663
9	MP0005187_abnormal_penis_morphology	1.84231702
10	MP0005499_abnormal_olfactory_system	1.83715637
11	MP0005394_taste/olfaction_phenotype	1.83715637
12	MP0002736_abnormal_nociception_after	1.74982615
13	MP0002751_abnormal_autonomic_nervous	1.74177430
14	MP0006276_abnormal_autonomic_nervous	1.72097448
15	MP0004147_increased_porphyrin_level	1.62363695
16	MP0001984_abnormal_olfaction	1.61304054
17	MP0002822_catalepsy	1.59188648
18	MP0008932_abnormal_embryonic_tissue	1.58910590
19	MP0003635_abnormal_synaptic_transmissio	1.58759325
20	MP0008058_abnormal_DNA_repair	1.58078424
21	MP0005248_abnormal_Harderian_gland	1.58037849
22	MP0006072_abnormal_retinal_apoptosis	1.56961242
23	MP0000049_abnormal_middle_ear	1.55922726
24	MP0002102_abnormal_ear_morphology	1.55115964
25	MP0005623_abnormal_meninges_morphology	1.52103708
26	MP0001177_atelectasis	1.50297113
27	MP0001486_abnormal_startle_reflex	1.47683641
28	MP0006292_abnormal_olfactory_placode	1.46140680
29	MP0010094_abnormal_chromosome_stability	1.43583992
30	MP0001968_abnormal_touch/_nociception	1.42611190
31	MP0002572_abnormal_emotion/affect_behav	1.38025866
32	MP0010386_abnormal_urinary_bladder	1.37402516
33	MP0003122_maternal_imprinting	1.37046071
34	MP0003937_abnormal_limbs/digits/tail_de	1.36236499
35	MP0002090_abnormal_vision	1.35638301
36	MP0002734_abnormal_mechanical_nocicepti	1.34220782
37	MP0002063_abnormal_learning/memory/cond	1.33998542
38	MP0000537_abnormal_urethra_morphology	1.30835257
39	MP0009384_cardiac_valve_regurgitation	1.30045092
40	MP0003755_abnormal_palate_morphology	1.29514604
41	MP0002938_white_spotting	1.28024447
42	MP0003941_abnormal_skin_development	1.23442787
43	MP0002638_abnormal_pupillary_reflex	1.22598894
44	MP0005253_abnormal_eye_physiology	1.22559942
45	MP0003385_abnormal_body_wall	1.20548458
46	MP0002272_abnormal_nervous_system	1.20083458
47	MP0004133_heterotaxia	1.18901711
48	MP0001299_abnormal_eye_distance/	1.16858524
49	MP0002233_abnormal_nose_morphology	1.15205977
50	MP0000647_abnormal_sebaceous_gland	1.14983501
51	MP0002234_abnormal_pharynx_morphology	1.13197832
52	MP0002735_abnormal_chemical_nociception	1.12899290
53	MP0009046_muscle_twitch	1.12708651
54	MP0002064_seizures	1.11623314
55	MP0002184_abnormal_innervation	1.11091490
56	MP0003861_abnormal_nervous_system	1.10299643
57	MP0001293_anophthalmia	1.10159544
58	MP0000631_abnormal_neuroendocrine_gland	1.08149479
59	MP0003136_yellow_coat_color	1.06130004
60	MP0009745_abnormal_behavioral_response	1.06021561
61	MP0003121_genomic_imprinting	1.05864486
62	MP0003111_abnormal_nucleus_morphology	1.05335535
63	MP0004811_abnormal_neuron_physiology	1.05318052
64	MP0002557_abnormal_social/conspecific_i	1.05284717
65	MP0003942_abnormal_urinary_system	1.04585352
66	MP0006054_spinal_hemorrhage	1.03913148
67	MP0009250_abnormal_appendicular_skeleto	1.01858878
68	MP0000534_abnormal_ureter_morphology	1.01291764
69	MP0002152_abnormal_brain_morphology	0.99015721
70	MP0005367_renal/urinary_system_phenotyp	0.98337362
71	MP0000516_abnormal_urinary_system	0.98337362
72	MP0002882_abnormal_neuron_morphology	0.96687533
73	MP0003119_abnormal_digestive_system	0.96198882
74	MP0000955_abnormal_spinal_cord	0.96107480
75	MP0004924_abnormal_behavior	0.93583959
76	MP0005386_behavior/neurological_phenoty	0.93583959
77	MP0008877_abnormal_DNA_methylation	0.93014871
78	MP0004215_abnormal_myocardial_fiber	0.92212933
79	MP0002752_abnormal_somatic_nervous	0.88455753
80	MP0003718_maternal_effect	0.88055590
81	MP0001286_abnormal_eye_development	0.87133211
82	MP0003890_abnormal_embryonic-extraembry	0.87024085
83	MP0003693_abnormal_embryo_hatching	0.85482173
84	MP0000026_abnormal_inner_ear	0.85188162
85	MP0003935_abnormal_craniofacial_develop	0.84596021
86	MP0005423_abnormal_somatic_nervous	0.83464481
87	MP0002697_abnormal_eye_size	0.82811896
88	MP0009780_abnormal_chondrocyte_physiolo	0.82735974
89	MP0002081_perinatal_lethality	0.82224230
90	MP0001970_abnormal_pain_threshold	0.81966625
91	MP0005391_vision/eye_phenotype	0.81080179
92	MP0001188_hyperpigmentation	0.79676247
93	MP0003938_abnormal_ear_development	0.77829164
94	MP0001270_distended_abdomen	0.76972803
95	MP0002067_abnormal_sensory_capabilities	0.76641073
96	MP0003077_abnormal_cell_cycle	0.76596369
97	MP0002066_abnormal_motor_capabilities/c	0.75980503
98	MP0010352_gastrointestinal_tract_polyps	0.75658723
99	MP0002733_abnormal_thermal_nociception	0.75115213
100	MP0003221_abnormal_cardiomyocyte_apopto	0.74186611

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cortical dysplasia (HP:0002539)	3.07790731
2	Abnormality of the labia minora (HP:0012880)	2.90593699
3	Drooling (HP:0002307)	2.78027838
4	Split foot (HP:0001839)	2.62037402
5	Gait imbalance (HP:0002141)	2.57376700
6	Colon cancer (HP:0003003)	2.54402375
7	Medial flaring of the eyebrow (HP:0010747)	2.48523161
8	Insidious onset (HP:0003587)	2.43081058
9	Termporal pattern (HP:0011008)	2.43081058
10	Excessive salivation (HP:0003781)	2.41262342
11	Abnormality of the musculature of the pelvis (HP:0001469)	2.41200310
12	Abnormality of the hip-girdle musculature (HP:0001445)	2.41200310
13	Congenital primary aphakia (HP:0007707)	2.36603584
14	Shoulder girdle muscle weakness (HP:0003547)	2.33179918
15	Focal motor seizures (HP:0011153)	2.30020965
16	Urinary urgency (HP:0000012)	2.22307565
17	Nephrogenic diabetes insipidus (HP:0009806)	2.19087230
18	Increased serum pyruvate (HP:0003542)	2.14650295
19	Heterochromia iridis (HP:0001100)	2.13641491
20	Impaired vibration sensation in the lower limbs (HP:0002166)	2.13444994
21	Medulloblastoma (HP:0002885)	2.11866642
22	Polyphagia (HP:0002591)	2.07167021
23	Abnormality of the metopic suture (HP:0005556)	2.01504586
24	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.01130930
25	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.01130930
26	Abnormality of the corticospinal tract (HP:0002492)	1.99615222
27	Large earlobe (HP:0009748)	1.99324163
28	Genital tract atresia (HP:0001827)	1.98358546
29	Astrocytoma (HP:0009592)	1.98011360
30	Abnormality of the astrocytes (HP:0100707)	1.98011360
31	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.96245998
32	Pancreatic fibrosis (HP:0100732)	1.96167716
33	Lissencephaly (HP:0001339)	1.96160983
34	Delayed gross motor development (HP:0002194)	1.95234763
35	True hermaphroditism (HP:0010459)	1.94717878
36	Broad foot (HP:0001769)	1.93781731
37	Vaginal atresia (HP:0000148)	1.92778531
38	Acute necrotizing encephalopathy (HP:0006965)	1.91318299
39	Atonic seizures (HP:0010819)	1.88663723
40	Postnatal microcephaly (HP:0005484)	1.88506492
41	Abnormality of glycolysis (HP:0004366)	1.86244397
42	Ependymoma (HP:0002888)	1.84323506
43	Specific learning disability (HP:0001328)	1.79586097
44	Acute encephalopathy (HP:0006846)	1.79478850
45	Abnormal mitochondria in muscle tissue (HP:0008316)	1.78978398
46	Limb dystonia (HP:0002451)	1.78065142
47	Rhabdomyosarcoma (HP:0002859)	1.77824795
48	Postaxial hand polydactyly (HP:0001162)	1.77441960
49	Abnormal auditory evoked potentials (HP:0006958)	1.76330067
50	Morphological abnormality of the middle ear (HP:0008609)	1.75187230
51	Pancreatic cysts (HP:0001737)	1.73957146
52	Spastic gait (HP:0002064)	1.73079025
53	Long clavicles (HP:0000890)	1.72683837
54	Action tremor (HP:0002345)	1.72647804
55	Glioma (HP:0009733)	1.72319926
56	Ankle clonus (HP:0011448)	1.71954967
57	Gonadotropin excess (HP:0000837)	1.71032263
58	Pachygyria (HP:0001302)	1.68810318
59	Hyperglycinemia (HP:0002154)	1.68763206
60	Myelomeningocele (HP:0002475)	1.68403220
61	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.68310016
62	Abnormality of alanine metabolism (HP:0010916)	1.68310016
63	Hyperalaninemia (HP:0003348)	1.68310016
64	Pelvic girdle muscle weakness (HP:0003749)	1.64288290
65	Focal seizures (HP:0007359)	1.63554390
66	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.60596400
67	Short 1st metacarpal (HP:0010034)	1.60596400
68	Progressive macrocephaly (HP:0004481)	1.59525553
69	Febrile seizures (HP:0002373)	1.58045861
70	Micropenis (HP:0000054)	1.57925311
71	Patchy hypopigmentation of hair (HP:0011365)	1.56848626
72	Hypsarrhythmia (HP:0002521)	1.56811537
73	Spastic diplegia (HP:0001264)	1.56218974
74	Fibular aplasia (HP:0002990)	1.56168661
75	Hypoplastic pelvis (HP:0008839)	1.56128831
76	White forelock (HP:0002211)	1.56074201
77	EEG with generalized epileptiform discharges (HP:0011198)	1.55864631
78	Progressive inability to walk (HP:0002505)	1.54873620
79	Myokymia (HP:0002411)	1.54623177
80	Broad-based gait (HP:0002136)	1.52962554
81	Abnormal lung lobation (HP:0002101)	1.52152685
82	Epileptiform EEG discharges (HP:0011182)	1.52093903
83	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.50833363
84	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.50006541
85	Intellectual disability, mild (HP:0001256)	1.49983593
86	Decreased lacrimation (HP:0000633)	1.49461129
87	Adrenal hypoplasia (HP:0000835)	1.49383209
88	Absent speech (HP:0001344)	1.49133856
89	Oligodactyly (HP:0012165)	1.49091751
90	Abnormality of the 1st metacarpal (HP:0010009)	1.48941799
91	Abnormal eating behavior (HP:0100738)	1.48563939
92	Decreased testicular size (HP:0008734)	1.47317549
93	Limb-girdle muscle weakness (HP:0003325)	1.47219997
94	Poor coordination (HP:0002370)	1.46561288
95	Partial agenesis of the corpus callosum (HP:0001338)	1.45505304
96	Oligodactyly (hands) (HP:0001180)	1.45422614
97	Aganglionic megacolon (HP:0002251)	1.45157715
98	Lower limb muscle weakness (HP:0007340)	1.44674587
99	Prominent metopic ridge (HP:0005487)	1.43605448
100	Retinal dysplasia (HP:0007973)	1.43492894

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCR	3.94093809
2	NEK1	3.27434568
3	TRIM28	3.23055886
4	MARK1	2.89740030
5	CASK	2.50726298
6	MAP2K7	2.47208195
7	SRPK1	2.42268217
8	MAP3K4	2.36719323
9	ERBB3	2.24758003
10	CCNB1	2.19124040
11	CSNK1G3	2.07338045
12	CSNK1G2	2.04474581
13	CSNK1A1L	1.93210765
14	EPHA4	1.91269321
15	CSNK1G1	1.82584862
16	MAPK13	1.80395850
17	PRKD3	1.79266755
18	LATS1	1.68083323
19	PLK2	1.63717312
20	WNK3	1.62660061
21	LIMK1	1.59332561
22	PAK6	1.58793292
23	MINK1	1.48824307
24	BMPR1B	1.39886501
25	TSSK6	1.38652120
26	BUB1	1.37281078
27	UHMK1	1.36645180
28	MKNK1	1.35972693
29	PLK4	1.33393592
30	DYRK2	1.30658983
31	PINK1	1.30393134
32	MAP4K2	1.29790664
33	TESK1	1.23467590
34	MKNK2	1.22134135
35	EIF2AK1	1.21113032
36	PLK3	1.19902396
37	WEE1	1.17159211
38	DYRK3	1.16995720
39	PAK3	1.16483816
40	PBK	1.14071271
41	RPS6KA4	1.12951674
42	EIF2AK3	1.07748997
43	NTRK2	1.07366140
44	AKT3	1.06725207
45	NEK9	1.02206591
46	TNIK	1.00271158
47	NUAK1	0.96468748
48	CDK14	0.95808094
49	EPHB2	0.95482491
50	PNCK	0.94808844
51	CDK18	0.89593185
52	BRSK2	0.88869132
53	PLK1	0.87586602
54	MST4	0.85825468
55	CDK15	0.78915076
56	STK39	0.78791359
57	TTK	0.78240661
58	CAMK2B	0.76797014
59	PRKCG	0.74637157
60	DYRK1B	0.71161791
61	MAP2K4	0.70126007
62	BCKDK	0.68776889
63	CDK11A	0.68072951
64	CAMK2A	0.67736553
65	BRSK1	0.66820489
66	KSR1	0.66336433
67	DDR2	0.65602238
68	PRKCE	0.65559482
69	LATS2	0.64998323
70	SIK3	0.61219821
71	NEK2	0.58727763
72	EPHA3	0.56052570
73	CDK5	0.55559191
74	STK38L	0.55362062
75	ROCK2	0.53421922
76	MET	0.52287234
77	AURKB	0.52011638
78	CSNK1A1	0.51464964
79	CAMK2D	0.49504913
80	ERBB4	0.47576577
81	NTRK3	0.47570355
82	CAMK2G	0.47266265
83	MAP3K6	0.46766213
84	NTRK1	0.46362213
85	VRK1	0.46355501
86	CDC7	0.44780089
87	PIK3CA	0.44518186
88	MYLK	0.43174902
89	DYRK1A	0.41770435
90	PAK2	0.41755820
91	PKN1	0.36260899
92	ATR	0.35307291
93	STK3	0.34778577
94	OXSR1	0.34155369
95	ATM	0.33332793
96	CDK6	0.30155808
97	PDGFRA	0.30064263
98	GRK5	0.29850816
99	CSNK1D	0.29749916
100	AURKA	0.29707298

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.36689448
2	Steroid biosynthesis_Homo sapiens_hsa00100	2.98774173
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.87282162
4	Nicotine addiction_Homo sapiens_hsa05033	2.11861798
5	Non-homologous end-joining_Homo sapiens_hsa03450	1.98568014
6	Mismatch repair_Homo sapiens_hsa03430	1.90070417
7	Protein export_Homo sapiens_hsa03060	1.85507723
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.80159048
9	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.59250797
10	Fanconi anemia pathway_Homo sapiens_hsa03460	1.59029918
11	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.58799163
12	GABAergic synapse_Homo sapiens_hsa04727	1.51208526
13	Basal transcription factors_Homo sapiens_hsa03022	1.45986267
14	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.45961019
15	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.43789927
16	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.36384312
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.33779218
18	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.29232133
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.29140594
20	Oocyte meiosis_Homo sapiens_hsa04114	1.26831060
21	Fatty acid elongation_Homo sapiens_hsa00062	1.26050522
22	Propanoate metabolism_Homo sapiens_hsa00640	1.25659489
23	Butanoate metabolism_Homo sapiens_hsa00650	1.25293479
24	Spliceosome_Homo sapiens_hsa03040	1.23615318
25	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.22397114
26	Base excision repair_Homo sapiens_hsa03410	1.21986068
27	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.20016179
28	Hippo signaling pathway_Homo sapiens_hsa04390	1.19259409
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.19090500
30	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.18596977
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.16624549
32	Cocaine addiction_Homo sapiens_hsa05030	1.13463703
33	Dopaminergic synapse_Homo sapiens_hsa04728	1.13153715
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.12617551
35	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.11654203
36	Glutamatergic synapse_Homo sapiens_hsa04724	1.11408639
37	Taste transduction_Homo sapiens_hsa04742	1.07437175
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.05653944
39	Amphetamine addiction_Homo sapiens_hsa05031	1.02869445
40	DNA replication_Homo sapiens_hsa03030	1.01583161
41	Pyruvate metabolism_Homo sapiens_hsa00620	1.00917508
42	Cell cycle_Homo sapiens_hsa04110	1.00019525
43	Circadian entrainment_Homo sapiens_hsa04713	0.97333692
44	Morphine addiction_Homo sapiens_hsa05032	0.97170409
45	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.95094075
46	Gap junction_Homo sapiens_hsa04540	0.94697564
47	Parkinsons disease_Homo sapiens_hsa05012	0.94534176
48	Vibrio cholerae infection_Homo sapiens_hsa05110	0.92430311
49	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.92051548
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90951184
51	Axon guidance_Homo sapiens_hsa04360	0.89106689
52	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.88132138
53	RNA polymerase_Homo sapiens_hsa03020	0.88108398
54	Homologous recombination_Homo sapiens_hsa03440	0.87842291
55	Alcoholism_Homo sapiens_hsa05034	0.86938181
56	Arginine and proline metabolism_Homo sapiens_hsa00330	0.86566570
57	RNA transport_Homo sapiens_hsa03013	0.84671666
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.82872052
59	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.81545298
60	Sulfur metabolism_Homo sapiens_hsa00920	0.80381840
61	Oxidative phosphorylation_Homo sapiens_hsa00190	0.78201526
62	Folate biosynthesis_Homo sapiens_hsa00790	0.77917393
63	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.76875274
64	Nitrogen metabolism_Homo sapiens_hsa00910	0.75453879
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.75338071
66	Proteasome_Homo sapiens_hsa03050	0.73918183
67	Basal cell carcinoma_Homo sapiens_hsa05217	0.70099951
68	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.69803374
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.66370593
70	Peroxisome_Homo sapiens_hsa04146	0.66314336
71	Huntingtons disease_Homo sapiens_hsa05016	0.66214668
72	mRNA surveillance pathway_Homo sapiens_hsa03015	0.66164401
73	Purine metabolism_Homo sapiens_hsa00230	0.65897574
74	Carbon metabolism_Homo sapiens_hsa01200	0.64791003
75	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.63750319
76	Wnt signaling pathway_Homo sapiens_hsa04310	0.63643069
77	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.58324066
78	Alzheimers disease_Homo sapiens_hsa05010	0.57046205
79	Melanogenesis_Homo sapiens_hsa04916	0.56839085
80	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.56607576
81	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.56194580
82	Gastric acid secretion_Homo sapiens_hsa04971	0.54586252
83	Glutathione metabolism_Homo sapiens_hsa00480	0.53110722
84	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.52993442
85	p53 signaling pathway_Homo sapiens_hsa04115	0.52939293
86	Serotonergic synapse_Homo sapiens_hsa04726	0.50522889
87	RNA degradation_Homo sapiens_hsa03018	0.50515940
88	Long-term depression_Homo sapiens_hsa04730	0.50354193
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49501692
90	Tight junction_Homo sapiens_hsa04530	0.49276680
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49031728
92	Adherens junction_Homo sapiens_hsa04520	0.47331674
93	Metabolic pathways_Homo sapiens_hsa01100	0.47272852
94	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.46965378
95	Insulin secretion_Homo sapiens_hsa04911	0.46858104
96	Cholinergic synapse_Homo sapiens_hsa04725	0.45400210
97	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.45043091
98	Sulfur relay system_Homo sapiens_hsa04122	0.44719612
99	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.43609849
100	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.43144304

C5ORF30

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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