C5ORF34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.19804738
2CENP-A containing nucleosome assembly (GO:0034080)5.84280891
3protein localization to chromosome, centromeric region (GO:0071459)5.68285595
4chromatin remodeling at centromere (GO:0031055)5.67516392
5mitotic metaphase plate congression (GO:0007080)5.64164424
6mitotic sister chromatid segregation (GO:0000070)5.28847018
7sister chromatid segregation (GO:0000819)5.18056605
8metaphase plate congression (GO:0051310)5.17479079
9mitotic chromosome condensation (GO:0007076)5.15372527
10kinetochore organization (GO:0051383)5.10509918
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.91430456
12DNA strand elongation involved in DNA replication (GO:0006271)4.86797426
13histone exchange (GO:0043486)4.82166541
14telomere maintenance via semi-conservative replication (GO:0032201)4.75704513
15DNA replication checkpoint (GO:0000076)4.71209914
16DNA strand elongation (GO:0022616)4.70943266
17establishment of chromosome localization (GO:0051303)4.63514748
18nuclear pore complex assembly (GO:0051292)4.58978647
19DNA replication-independent nucleosome assembly (GO:0006336)4.51663987
20DNA replication-independent nucleosome organization (GO:0034724)4.51663987
21regulation of spindle organization (GO:0090224)4.51622993
22kinetochore assembly (GO:0051382)4.44490352
23spindle checkpoint (GO:0031577)4.39292111
24nuclear pore organization (GO:0006999)4.32335895
25mitotic sister chromatid cohesion (GO:0007064)4.29274352
26mitotic recombination (GO:0006312)4.26522243
27telomere maintenance via recombination (GO:0000722)4.22208909
28regulation of mitotic spindle organization (GO:0060236)4.16221191
29DNA ligation (GO:0006266)4.15029151
30mitotic nuclear envelope disassembly (GO:0007077)4.09827335
31mitotic spindle checkpoint (GO:0071174)4.09527328
32protein localization to chromosome (GO:0034502)4.08919044
33negative regulation of chromosome segregation (GO:0051985)4.08000431
34regulation of chromosome segregation (GO:0051983)4.07954524
35negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.07210797
36negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.07210797
37negative regulation of mitotic sister chromatid segregation (GO:0033048)4.07210797
38negative regulation of mitotic sister chromatid separation (GO:2000816)4.07210797
39negative regulation of sister chromatid segregation (GO:0033046)4.07210797
40regulation of centriole replication (GO:0046599)4.06693964
41DNA unwinding involved in DNA replication (GO:0006268)4.02847549
42regulation of mitotic metaphase/anaphase transition (GO:0030071)4.02220761
43regulation of metaphase/anaphase transition of cell cycle (GO:1902099)4.02220761
44attachment of spindle microtubules to kinetochore (GO:0008608)3.96821411
45chromosome segregation (GO:0007059)3.96341968
46mitotic spindle assembly checkpoint (GO:0007094)3.93619448
47spindle assembly checkpoint (GO:0071173)3.93560759
48regulation of mitotic sister chromatid separation (GO:0010965)3.91336773
49regulation of mitotic sister chromatid segregation (GO:0033047)3.91336773
50regulation of sister chromatid segregation (GO:0033045)3.91336773
51synapsis (GO:0007129)3.88544125
52centriole replication (GO:0007099)3.87136948
53microtubule depolymerization (GO:0007019)3.86351297
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.84373568
55membrane disassembly (GO:0030397)3.82619206
56nuclear envelope disassembly (GO:0051081)3.82619206
57regulation of centrosome cycle (GO:0046605)3.78737666
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76738317
59regulation of mitotic spindle checkpoint (GO:1903504)3.75525701
60regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.75525701
61DNA topological change (GO:0006265)3.72528227
62positive regulation of chromosome segregation (GO:0051984)3.71418387
63regulation of DNA endoreduplication (GO:0032875)3.69308188
64DNA replication initiation (GO:0006270)3.66448487
65chromosome condensation (GO:0030261)3.60722593
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.54138443
67mitotic G2/M transition checkpoint (GO:0044818)3.53375546
68telomere maintenance via telomere lengthening (GO:0010833)3.48248584
69regulation of spindle checkpoint (GO:0090231)3.47614675
70positive regulation of mitotic sister chromatid separation (GO:1901970)3.45446807
71positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.45446807
72positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.45446807
73establishment of integrated proviral latency (GO:0075713)3.44967650
74chromatin assembly or disassembly (GO:0006333)3.41508768
75pore complex assembly (GO:0046931)3.41449454
76meiotic chromosome segregation (GO:0045132)3.39701111
77proteasome assembly (GO:0043248)3.37817473
78DNA replication-dependent nucleosome assembly (GO:0006335)3.37101621
79DNA replication-dependent nucleosome organization (GO:0034723)3.37101621
80regulation of double-strand break repair via homologous recombination (GO:0010569)3.37008927
81protein K6-linked ubiquitination (GO:0085020)3.33428499
82negative regulation of DNA-dependent DNA replication (GO:2000104)3.33036430
83replication fork processing (GO:0031297)3.30418194
84negative regulation of mitosis (GO:0045839)3.30099071
85DNA packaging (GO:0006323)3.25698517
86ATP-dependent chromatin remodeling (GO:0043044)3.23525468
87resolution of meiotic recombination intermediates (GO:0000712)3.22204744
88mitotic cell cycle (GO:0000278)3.21239767
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19406339
90maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12051374
91chromosome organization involved in meiosis (GO:0070192)3.10140978
92sister chromatid cohesion (GO:0007062)3.09983599
93chromosome organization (GO:0051276)3.05516202
94ventricular cardiac muscle cell development (GO:0055015)3.05327550
95non-recombinational repair (GO:0000726)3.03315837
96double-strand break repair via nonhomologous end joining (GO:0006303)3.03315837
97regulation of centrosome duplication (GO:0010824)3.03286457
98negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01200169
99base-excision repair (GO:0006284)3.00704329
100positive regulation of cell cycle checkpoint (GO:1901978)2.99379737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.78780669
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.46502076
3E2F4_17652178_ChIP-ChIP_JURKAT_Human5.24214969
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.55791782
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.41368928
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.47347067
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.16167149
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.14642353
9AR_21909140_ChIP-Seq_LNCAP_Human3.07492290
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.03380122
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.01018223
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.82548557
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.76936247
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45446393
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.44937339
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42430065
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.39387681
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39116071
19ELK1_19687146_ChIP-ChIP_HELA_Human2.37396721
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.37063668
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36102601
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.29858526
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28744337
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26231557
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18045732
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11649633
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10113373
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07188910
29VDR_23849224_ChIP-Seq_CD4+_Human1.98702239
30DCP1A_22483619_ChIP-Seq_HELA_Human1.98454073
31* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98048598
32FOXP3_21729870_ChIP-Seq_TREG_Human1.97187243
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.94765282
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88548052
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88441105
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84110861
37TTF2_22483619_ChIP-Seq_HELA_Human1.82537044
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82323815
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77532764
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76339215
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75563713
42XRN2_22483619_ChIP-Seq_HELA_Human1.72110721
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61914788
44* GABP_19822575_ChIP-Seq_HepG2_Human1.58166731
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57487767
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55156446
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38287151
48EWS_26573619_Chip-Seq_HEK293_Human1.38128473
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35329100
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.34231841
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33491216
52E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32686159
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31758209
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30871255
55MYC_18940864_ChIP-ChIP_HL60_Human1.30169696
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.21109763
57KDM5A_27292631_Chip-Seq_BREAST_Human1.20330016
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19708617
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16713588
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.15998987
61FUS_26573619_Chip-Seq_HEK293_Human1.15658813
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11864067
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10932563
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10016982
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09757270
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06876611
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99316673
68NANOG_16153702_ChIP-ChIP_HESCs_Human0.98942721
69SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97516770
70SOX2_16153702_ChIP-ChIP_HESCs_Human0.96587995
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94012450
72ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93635739
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91938467
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90233320
75NOTCH1_21737748_ChIP-Seq_TLL_Human0.89322074
76POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89074227
77RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88435422
78SOX17_20123909_ChIP-Seq_XEN_Mouse0.87903064
79IRF1_19129219_ChIP-ChIP_H3396_Human0.85386810
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79553297
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79116012
82POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78357209
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.73950215
84TFEB_21752829_ChIP-Seq_HELA_Human0.72806803
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71147697
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70147729
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.69169876
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.68167328
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.68016516
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.67815481
91ZNF274_21170338_ChIP-Seq_K562_Hela0.67502938
92CIITA_25753668_ChIP-Seq_RAJI_Human0.62416426
93KLF4_18555785_ChIP-Seq_MESCs_Mouse0.61830782
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.61085466
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.60595149
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.60193553
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.59701272
98VDR_22108803_ChIP-Seq_LS180_Human0.59332311
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.58022799
100GATA1_26923725_Chip-Seq_HPCs_Mouse0.57055129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.57202376
2MP0003693_abnormal_embryo_hatching5.04156521
3MP0003111_abnormal_nucleus_morphology4.42368862
4MP0008058_abnormal_DNA_repair4.41278017
5MP0008057_abnormal_DNA_replication4.36981368
6MP0003077_abnormal_cell_cycle4.06323559
7MP0004957_abnormal_blastocyst_morpholog3.89442860
8MP0003718_maternal_effect3.85813729
9MP0008932_abnormal_embryonic_tissue3.21423688
10MP0006292_abnormal_olfactory_placode2.94232920
11MP0008877_abnormal_DNA_methylation2.62104678
12MP0008007_abnormal_cellular_replicative2.40516696
13MP0009697_abnormal_copulation2.09918732
14MP0003890_abnormal_embryonic-extraembry2.02855449
15MP0010030_abnormal_orbit_morphology2.02144342
16MP0003786_premature_aging1.89496895
17MP0010307_abnormal_tumor_latency1.82419375
18MP0008789_abnormal_olfactory_epithelium1.80454113
19MP0000350_abnormal_cell_proliferation1.76741497
20MP0001730_embryonic_growth_arrest1.73789558
21MP0001293_anophthalmia1.68965327
22MP0002210_abnormal_sex_determination1.67229329
23MP0001697_abnormal_embryo_size1.65717399
24MP0001929_abnormal_gametogenesis1.65578237
25MP0001672_abnormal_embryogenesis/_devel1.54748359
26MP0005380_embryogenesis_phenotype1.54748359
27MP0002084_abnormal_developmental_patter1.34871045
28MP0005394_taste/olfaction_phenotype1.34772337
29MP0005499_abnormal_olfactory_system1.34772337
30MP0000653_abnormal_sex_gland1.33743889
31MP0002160_abnormal_reproductive_system1.33476129
32MP0001145_abnormal_male_reproductive1.32707495
33MP0002938_white_spotting1.31879538
34MP0002080_prenatal_lethality1.30480756
35MP0002234_abnormal_pharynx_morphology1.30064121
36MP0000313_abnormal_cell_death1.29323902
37MP0002085_abnormal_embryonic_tissue1.28979149
38MP0003937_abnormal_limbs/digits/tail_de1.27355229
39MP0005395_other_phenotype1.26104907
40MP0003806_abnormal_nucleotide_metabolis1.23982404
41MP0003984_embryonic_growth_retardation1.20674239
42MP0003699_abnormal_female_reproductive1.18132292
43MP0002088_abnormal_embryonic_growth/wei1.17806107
44MP0002396_abnormal_hematopoietic_system1.15388037
45MP0003941_abnormal_skin_development1.14286445
46MP0002102_abnormal_ear_morphology1.13749752
47MP0003950_abnormal_plasma_membrane1.10773258
48MP0006035_abnormal_mitochondrial_morpho1.08891558
49MP0006072_abnormal_retinal_apoptosis1.06821493
50MP0004197_abnormal_fetal_growth/weight/1.06053765
51MP0001119_abnormal_female_reproductive1.05277751
52MP0001661_extended_life_span1.04256798
53MP0002697_abnormal_eye_size1.02840483
54MP0001286_abnormal_eye_development1.02356678
55MP0000358_abnormal_cell_content/1.01784820
56MP0006036_abnormal_mitochondrial_physio1.01486989
57MP0003121_genomic_imprinting0.98585917
58MP0003698_abnormal_male_reproductive0.96833918
59MP0010352_gastrointestinal_tract_polyps0.96609942
60MP0002161_abnormal_fertility/fecundity0.96147187
61MP0002233_abnormal_nose_morphology0.95982900
62MP0001529_abnormal_vocalization0.89103762
63MP0002019_abnormal_tumor_incidence0.88974549
64MP0002086_abnormal_extraembryonic_tissu0.87782973
65MP0000049_abnormal_middle_ear0.87177480
66MP0009672_abnormal_birth_weight0.83663184
67MP0008995_early_reproductive_senescence0.83155639
68MP0003186_abnormal_redox_activity0.81919946
69MP0003567_abnormal_fetal_cardiomyocyte0.80228235
70MP0002111_abnormal_tail_morphology0.79807091
71MP0002092_abnormal_eye_morphology0.78922256
72MP0003119_abnormal_digestive_system0.78518354
73MP0001346_abnormal_lacrimal_gland0.77486758
74MP0003136_yellow_coat_color0.76723721
75MP0005389_reproductive_system_phenotype0.76127165
76MP0000569_abnormal_digit_pigmentation0.75843384
77MP0000372_irregular_coat_pigmentation0.75174242
78MP0003755_abnormal_palate_morphology0.73496680
79MP0002095_abnormal_skin_pigmentation0.71318412
80MP0000427_abnormal_hair_cycle0.71167861
81MP0005384_cellular_phenotype0.68457024
82MP0009703_decreased_birth_body0.68297710
83MP0000537_abnormal_urethra_morphology0.67654900
84MP0005391_vision/eye_phenotype0.66537442
85MP0003315_abnormal_perineum_morphology0.66454852
86MP0002132_abnormal_respiratory_system0.65208122
87MP0000490_abnormal_crypts_of0.64535005
88MP0000631_abnormal_neuroendocrine_gland0.64493081
89MP0003935_abnormal_craniofacial_develop0.62764496
90MP0003861_abnormal_nervous_system0.61752783
91MP0001324_abnormal_eye_pigmentation0.61149442
92MP0000647_abnormal_sebaceous_gland0.61066916
93MP0002751_abnormal_autonomic_nervous0.60528535
94MP0005410_abnormal_fertilization0.59337712
95MP0005501_abnormal_skin_physiology0.58827781
96MP0005075_abnormal_melanosome_morpholog0.57357951
97MP0005171_absent_coat_pigmentation0.56355612
98MP0002163_abnormal_gland_morphology0.54809648
99MP0005076_abnormal_cell_differentiation0.54440881
100MP0005621_abnormal_cell_physiology0.54130260

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.30157001
2Chromsome breakage (HP:0040012)6.04667003
3Abnormality of chromosome stability (HP:0003220)4.51906062
4Aplasia/Hypoplasia of the uvula (HP:0010293)4.36709494
5Meckel diverticulum (HP:0002245)4.28093118
6Small intestinal stenosis (HP:0012848)4.14205741
7Duodenal stenosis (HP:0100867)4.14205741
8Abnormality of the ileum (HP:0001549)4.12332186
9Abnormality of the preputium (HP:0100587)4.10005844
10Abnormal lung lobation (HP:0002101)3.65801021
11Volvulus (HP:0002580)3.64544494
12Abnormality of the duodenum (HP:0002246)3.44444031
13Supernumerary spleens (HP:0009799)3.41781208
14Nephroblastoma (Wilms tumor) (HP:0002667)3.39160028
15Embryonal renal neoplasm (HP:0011794)3.31608828
16Birth length less than 3rd percentile (HP:0003561)3.24675156
17Increased nuchal translucency (HP:0010880)3.14975570
18Myelodysplasia (HP:0002863)3.01152435
19Abnormality of the labia minora (HP:0012880)2.94920386
20Absent radius (HP:0003974)2.92626456
21Abnormality of the carotid arteries (HP:0005344)2.86484998
22Reticulocytopenia (HP:0001896)2.85755398
23Oligodactyly (hands) (HP:0001180)2.81509369
24Sloping forehead (HP:0000340)2.74817284
25Clubbing of toes (HP:0100760)2.74779768
26Absent forearm bone (HP:0003953)2.73447537
27Aplasia involving forearm bones (HP:0009822)2.73447537
28Ectopic kidney (HP:0000086)2.59341038
29Triphalangeal thumb (HP:0001199)2.53846895
30Facial hemangioma (HP:0000329)2.51586508
31Cortical dysplasia (HP:0002539)2.50386961
32Short middle phalanx of the 5th finger (HP:0004220)2.49327838
33Horseshoe kidney (HP:0000085)2.48594873
34Duplicated collecting system (HP:0000081)2.41821392
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.32525935
36Type I transferrin isoform profile (HP:0003642)2.24918122
37Median cleft lip (HP:0000161)2.21921445
38Rhabdomyosarcoma (HP:0002859)2.20959532
39Absent thumb (HP:0009777)2.18247660
40Abnormality of the renal collecting system (HP:0004742)2.17883264
41Cafe-au-lait spot (HP:0000957)2.14958672
42Abnormality of the septum pellucidum (HP:0007375)2.14475413
43Absent septum pellucidum (HP:0001331)2.14328792
44Colon cancer (HP:0003003)2.13819735
45Oligodactyly (HP:0012165)2.12526692
46Choanal atresia (HP:0000453)2.11145663
47Neoplasm of the colon (HP:0100273)2.07137065
48Short thumb (HP:0009778)2.05891544
49Microvesicular hepatic steatosis (HP:0001414)2.04594759
50Arteriovenous malformation (HP:0100026)2.02713820
51Abnormality of DNA repair (HP:0003254)2.02293549
52Short tibia (HP:0005736)1.97039421
53Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.94602588
54Bone marrow hypocellularity (HP:0005528)1.93804083
55Gonadotropin excess (HP:0000837)1.93565953
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92047699
57Abnormal protein N-linked glycosylation (HP:0012347)1.92047699
58Abnormal protein glycosylation (HP:0012346)1.92047699
59Abnormal glycosylation (HP:0012345)1.92047699
60Acute necrotizing encephalopathy (HP:0006965)1.92030051
61Embryonal neoplasm (HP:0002898)1.91053618
62Abnormality of chromosome segregation (HP:0002916)1.85583410
63Impulsivity (HP:0100710)1.84789980
64Carpal bone hypoplasia (HP:0001498)1.83421288
65Aplasia/Hypoplasia of the sternum (HP:0006714)1.83335539
66Medulloblastoma (HP:0002885)1.81697735
67Abnormal mitochondria in muscle tissue (HP:0008316)1.81255359
68Overlapping toe (HP:0001845)1.80025082
69Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.79109621
70Macrocytic anemia (HP:0001972)1.78933585
71Abnormality of cochlea (HP:0000375)1.77785111
72Acute encephalopathy (HP:0006846)1.77420669
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.76479125
74Duplication of thumb phalanx (HP:0009942)1.75963564
75Increased CSF lactate (HP:0002490)1.75641521
76Bifid tongue (HP:0010297)1.73800079
77Septo-optic dysplasia (HP:0100842)1.72874976
78Glioma (HP:0009733)1.72832170
79Reduced antithrombin III activity (HP:0001976)1.72742980
80Multiple enchondromatosis (HP:0005701)1.72368609
81Hypoplastic pelvis (HP:0008839)1.72363135
82Premature ovarian failure (HP:0008209)1.70976996
83Astigmatism (HP:0000483)1.70254175
84Patellar aplasia (HP:0006443)1.69683359
85Ependymoma (HP:0002888)1.69407115
86Proximal placement of thumb (HP:0009623)1.68770480
87Increased hepatocellular lipid droplets (HP:0006565)1.66528244
88Cerebral edema (HP:0002181)1.65881974
89Facial cleft (HP:0002006)1.63557374
90Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.63427620
91Capillary hemangiomas (HP:0005306)1.62664696
92Aplasia/Hypoplasia of the patella (HP:0006498)1.61586672
93Combined immunodeficiency (HP:0005387)1.59795206
94Abnormality of the fetal cardiovascular system (HP:0010948)1.59582751
95Abnormal umbilical cord blood vessels (HP:0011403)1.59582751
96Single umbilical artery (HP:0001195)1.59582751
97Abnormality of methionine metabolism (HP:0010901)1.59267720
98Abnormality of pyrimidine metabolism (HP:0004353)1.58691542
99Abnormality of the pons (HP:0007361)1.57777586
100Aplasia/Hypoplasia of the earlobes (HP:0009906)1.57440566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.14379531
2TTK4.24099784
3CDC73.73124840
4WEE13.72864932
5NEK13.09429664
6PBK2.98322210
7SRPK12.89424681
8PLK42.88538479
9BRSK22.81474219
10EIF2AK12.80612225
11EIF2AK32.47361867
12PLK32.43268013
13ZAK2.30847025
14PLK12.08845112
15VRK22.00102148
16TSSK61.98289505
17CCNB11.96967344
18NEK21.93164992
19BRSK11.88376590
20PDK21.87288251
21MKNK11.78438485
22MKNK21.67364040
23CHEK21.63990625
24VRK11.63427426
25BRAF1.61425835
26AURKB1.54590657
27TRIM281.53432588
28MST41.48140982
29ATR1.44795465
30PNCK1.32069395
31NUAK11.27709278
32CDK71.24340844
33CDK121.19357575
34CDK81.17441585
35STK31.16880773
36EIF2AK21.14762306
37AURKA1.11760690
38CHEK11.10624417
39ATM0.98951587
40STK160.95989730
41STK40.92478522
42TAF10.89721104
43MAP3K80.84722746
44LATS10.82118029
45MELK0.79691489
46BMPR1B0.78569159
47RPS6KA40.76768982
48ARAF0.76544489
49NME10.75975023
50CDK30.75762742
51CDK10.71923094
52MET0.68754149
53PLK20.67866328
54MAP3K90.66974150
55BRD40.64202510
56CDK90.64002426
57CDK20.63945696
58WNK30.63819089
59MAP4K20.63432808
60RAF10.62498637
61SCYL20.61601059
62STK240.59362587
63NEK60.57049810
64RPS6KB20.56226721
65NEK90.54741529
66ERBB30.50456074
67NME20.50412169
68STK38L0.50119850
69PRKCI0.49181910
70MST1R0.49113395
71CSNK2A20.49084425
72PASK0.48437061
73CSNK2A10.47578057
74CSNK1G10.46994124
75CLK10.46713481
76ERBB40.46451341
77BCR0.46241752
78TLK10.45118896
79ACVR1B0.44441493
80DYRK30.43217515
81MARK30.38816193
82TNIK0.37330859
83CDK40.37047849
84MAPK130.35805218
85TGFBR10.34626885
86CSNK1E0.34451688
87CSNK1G30.33730262
88PRKDC0.32991388
89RPS6KA50.30033631
90STK100.28892785
91PAK10.28035535
92FLT30.26805609
93PAK40.26301983
94CDK180.26184771
95CDK150.24564837
96CSNK1A1L0.22971156
97ALK0.22542734
98CDK140.22255441
99CDK60.21177362
100CDK11A0.20828973

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.78432652
2Mismatch repair_Homo sapiens_hsa034304.51069805
3Homologous recombination_Homo sapiens_hsa034403.60722903
4Cell cycle_Homo sapiens_hsa041103.38363084
5Non-homologous end-joining_Homo sapiens_hsa034503.31597138
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17963400
7Fanconi anemia pathway_Homo sapiens_hsa034603.15766665
8Base excision repair_Homo sapiens_hsa034103.11754149
9Nucleotide excision repair_Homo sapiens_hsa034202.94224329
10Proteasome_Homo sapiens_hsa030502.93145414
11RNA transport_Homo sapiens_hsa030132.62093566
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.55227580
13Basal transcription factors_Homo sapiens_hsa030222.49826158
14Spliceosome_Homo sapiens_hsa030402.46412460
15RNA degradation_Homo sapiens_hsa030182.19082292
16RNA polymerase_Homo sapiens_hsa030202.09256183
17Ribosome_Homo sapiens_hsa030102.06423233
18Protein export_Homo sapiens_hsa030601.80933405
19Oocyte meiosis_Homo sapiens_hsa041141.80756978
20One carbon pool by folate_Homo sapiens_hsa006701.78391901
21Pyrimidine metabolism_Homo sapiens_hsa002401.70889560
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.61152305
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47103758
24p53 signaling pathway_Homo sapiens_hsa041151.41609780
25mRNA surveillance pathway_Homo sapiens_hsa030151.34830829
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32314151
27Purine metabolism_Homo sapiens_hsa002301.29526285
28Pyruvate metabolism_Homo sapiens_hsa006201.27128153
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24348071
30Selenocompound metabolism_Homo sapiens_hsa004501.23232804
31Parkinsons disease_Homo sapiens_hsa050121.20770794
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19924228
33Oxidative phosphorylation_Homo sapiens_hsa001901.19258988
34Folate biosynthesis_Homo sapiens_hsa007901.16650206
35Huntingtons disease_Homo sapiens_hsa050161.15765434
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10219256
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07976726
38Propanoate metabolism_Homo sapiens_hsa006401.06118310
39Biosynthesis of amino acids_Homo sapiens_hsa012301.05236083
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95039949
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90280448
42Steroid biosynthesis_Homo sapiens_hsa001000.86405576
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80767919
44Carbon metabolism_Homo sapiens_hsa012000.78920718
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77331871
46Fatty acid elongation_Homo sapiens_hsa000620.74149246
47Glutathione metabolism_Homo sapiens_hsa004800.69491678
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63053404
49Systemic lupus erythematosus_Homo sapiens_hsa053220.61264248
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61116311
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60552544
52TGF-beta signaling pathway_Homo sapiens_hsa043500.60480853
53Vitamin B6 metabolism_Homo sapiens_hsa007500.59458120
54N-Glycan biosynthesis_Homo sapiens_hsa005100.58295364
55Alzheimers disease_Homo sapiens_hsa050100.58114310
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54967743
57Viral carcinogenesis_Homo sapiens_hsa052030.48754958
58Alcoholism_Homo sapiens_hsa050340.47217848
59Pentose phosphate pathway_Homo sapiens_hsa000300.45290615
60Metabolic pathways_Homo sapiens_hsa011000.43705039
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43682080
62Epstein-Barr virus infection_Homo sapiens_hsa051690.41622312
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.40118902
64Thyroid cancer_Homo sapiens_hsa052160.39477605
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38480584
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38414979
67Butanoate metabolism_Homo sapiens_hsa006500.35273378
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35060897
69Hippo signaling pathway_Homo sapiens_hsa043900.34697452
70MicroRNAs in cancer_Homo sapiens_hsa052060.34490265
71Lysine degradation_Homo sapiens_hsa003100.33760314
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32750763
73HTLV-I infection_Homo sapiens_hsa051660.32235972
74Sulfur relay system_Homo sapiens_hsa041220.31665984
75Basal cell carcinoma_Homo sapiens_hsa052170.30950861
76Small cell lung cancer_Homo sapiens_hsa052220.30739225
77Wnt signaling pathway_Homo sapiens_hsa043100.24089680
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23958406
79Regulation of autophagy_Homo sapiens_hsa041400.23341182
80Hedgehog signaling pathway_Homo sapiens_hsa043400.23160668
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22435317
82Caffeine metabolism_Homo sapiens_hsa002320.18834513
83Phototransduction_Homo sapiens_hsa047440.17649576
84Olfactory transduction_Homo sapiens_hsa047400.17554747
85Herpes simplex infection_Homo sapiens_hsa051680.14186513
86Peroxisome_Homo sapiens_hsa041460.14005931
87beta-Alanine metabolism_Homo sapiens_hsa004100.13882060
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12945572
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.11938176
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.10354122
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08252076
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.07974026
93Vitamin digestion and absorption_Homo sapiens_hsa049770.06618428
94Adherens junction_Homo sapiens_hsa045200.05388979
95Colorectal cancer_Homo sapiens_hsa052100.04563988
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.04541812
97Circadian rhythm_Homo sapiens_hsa047100.04169914
98Nitrogen metabolism_Homo sapiens_hsa009100.02209540
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.01892714
100Arginine biosynthesis_Homo sapiens_hsa002200.01731140

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