C5ORF38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1segment specification (GO:0007379)6.00592749
2desmosome organization (GO:0002934)4.93247983
3regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.75336534
4establishment of apical/basal cell polarity (GO:0035089)3.37615303
5mammary gland epithelial cell differentiation (GO:0060644)3.33002352
6regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.31196927
7regulation of water loss via skin (GO:0033561)3.27169815
8keratinocyte development (GO:0003334)3.16517231
9epithelial cell fate commitment (GO:0072148)3.16502022
10L-alpha-amino acid transmembrane transport (GO:1902475)3.14958013
11nitric oxide biosynthetic process (GO:0006809)3.14233214
12lens fiber cell development (GO:0070307)3.09631530
13polarized epithelial cell differentiation (GO:0030859)3.00299504
14establishment or maintenance of monopolar cell polarity (GO:0061339)2.99572409
15establishment of monopolar cell polarity (GO:0061162)2.99572409
16norepinephrine metabolic process (GO:0042415)2.98472316
17negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.96867645
18negative regulation of execution phase of apoptosis (GO:1900118)2.95453328
19positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.91612433
20cardiac right ventricle morphogenesis (GO:0003215)2.91044533
21planar cell polarity pathway involved in neural tube closure (GO:0090179)2.89330530
22viral transcription (GO:0019083)2.80438854
23ear development (GO:0043583)2.78030040
24phenylpropanoid metabolic process (GO:0009698)2.71267237
25establishment of skin barrier (GO:0061436)2.70610603
26auditory receptor cell differentiation (GO:0042491)2.70468128
27apical protein localization (GO:0045176)2.69170688
28translational termination (GO:0006415)2.67882387
29hemidesmosome assembly (GO:0031581)2.66571632
30amyloid precursor protein catabolic process (GO:0042987)2.65473069
31regulation of extracellular matrix disassembly (GO:0010715)2.65382827
32ribosomal small subunit biogenesis (GO:0042274)2.64990225
33glandular epithelial cell differentiation (GO:0002067)2.63142094
34multicellular organismal water homeostasis (GO:0050891)2.61400494
35positive regulation of gluconeogenesis (GO:0045722)2.61274611
36response to food (GO:0032094)2.60560572
37ectoderm development (GO:0007398)2.58231139
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.57187361
39L-phenylalanine metabolic process (GO:0006558)2.57187361
40positive regulation of gastrulation (GO:2000543)2.55806284
41GDP-mannose metabolic process (GO:0019673)2.55205803
42paraxial mesoderm development (GO:0048339)2.54515543
43body morphogenesis (GO:0010171)2.53509799
44regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.52372384
45cell differentiation involved in embryonic placenta development (GO:0060706)2.51967967
46negative regulation of keratinocyte proliferation (GO:0010839)2.51571110
47endothelial cell chemotaxis (GO:0035767)2.50910925
48non-canonical Wnt signaling pathway (GO:0035567)2.50699214
49establishment of tissue polarity (GO:0007164)2.50577408
50establishment of planar polarity (GO:0001736)2.50577408
51epithelial cell-cell adhesion (GO:0090136)2.50086506
52dorsal/ventral neural tube patterning (GO:0021904)2.48823057
53proximal/distal pattern formation (GO:0009954)2.48218000
54calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.48051246
55positive regulation of keratinocyte differentiation (GO:0045618)2.44286370
56branching involved in salivary gland morphogenesis (GO:0060445)2.44275995
57bundle of His cell to Purkinje myocyte communication (GO:0086069)2.44263512
58Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.43876400
59cell-cell junction maintenance (GO:0045217)2.43568921
60type B pancreatic cell proliferation (GO:0044342)2.42723239
61hepatocyte apoptotic process (GO:0097284)2.42655963
62cranial nerve development (GO:0021545)2.41347449
63positive regulation of epidermal cell differentiation (GO:0045606)2.41293051
64negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.41147454
65SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.40039297
66sphingomyelin metabolic process (GO:0006684)2.38970030
67lung-associated mesenchyme development (GO:0060484)2.38655240
68glucocorticoid biosynthetic process (GO:0006704)2.37447281
69atrioventricular valve morphogenesis (GO:0003181)2.36972473
70protein targeting to ER (GO:0045047)2.35563742
71establishment or maintenance of bipolar cell polarity (GO:0061245)2.34890909
72establishment or maintenance of apical/basal cell polarity (GO:0035088)2.34890909
73cotranslational protein targeting to membrane (GO:0006613)2.33525147
74L-serine transport (GO:0015825)2.33434344
75viral life cycle (GO:0019058)2.33313127
76lung epithelium development (GO:0060428)2.33187162
77hippo signaling (GO:0035329)2.32859032
78regulation of translational fidelity (GO:0006450)2.32800731
79cerebellar Purkinje cell layer development (GO:0021680)2.32375463
80regulation of cell proliferation involved in kidney development (GO:1901722)2.32012169
81establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.31913403
82axon regeneration (GO:0031103)2.31770976
83tight junction assembly (GO:0070830)2.31054514
84asymmetric protein localization (GO:0008105)2.30441524
85neuron fate specification (GO:0048665)2.29738860
86face development (GO:0060324)2.27728599
87regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.27601983
88establishment of protein localization to endoplasmic reticulum (GO:0072599)2.27457850
89protein maturation by protein folding (GO:0022417)2.27374780
90protein localization to endoplasmic reticulum (GO:0070972)2.26197803
91regulation of apoptotic process involved in morphogenesis (GO:1902337)2.26049184
92response to parathyroid hormone (GO:0071107)2.25876613
93translational elongation (GO:0006414)2.25557226
94protein heterotrimerization (GO:0070208)2.25093566
95regulation of establishment of planar polarity (GO:0090175)2.23356403
96metanephros development (GO:0001656)2.23172244
97positive regulation of epidermis development (GO:0045684)2.22003349
98hypothalamus development (GO:0021854)2.21912481
99surfactant homeostasis (GO:0043129)2.21154312
100pattern specification involved in kidney development (GO:0061004)10.3228362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.48008171
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.80257543
3ESR2_21235772_ChIP-Seq_MCF-7_Human3.53121563
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.46853935
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.67907614
6RACK7_27058665_Chip-Seq_MCF-7_Human2.67010316
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.65332695
8TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.49021180
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30265642
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14591494
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.09169911
12ZNF263_19887448_ChIP-Seq_K562_Human2.08423625
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99348897
14LXR_22292898_ChIP-Seq_THP-1_Human1.98899225
15* ERG_21242973_ChIP-ChIP_JURKAT_Human1.94164721
16HIF1A_21447827_ChIP-Seq_MCF-7_Human1.87787960
17ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.84374010
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.84162259
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.79939085
20* RUNX1_27514584_Chip-Seq_MCF-7_Human1.68468293
21TP53_20018659_ChIP-ChIP_R1E_Mouse1.54004494
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50567268
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50181063
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43922842
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41733099
26UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41440865
27CTCF_18555785_ChIP-Seq_MESCs_Mouse1.40365352
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39870279
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.39653483
30CTCF_27219007_Chip-Seq_Bcells_Human1.37303606
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.34961920
32P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34917701
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34766833
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.34126307
35ATF3_27146783_Chip-Seq_COLON_Human1.33458007
36* SMC4_20622854_ChIP-Seq_HELA_Human1.32971058
37KDM2B_26808549_Chip-Seq_K562_Human1.32610305
38SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32472579
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32172106
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.31894032
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29277380
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28421060
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26284254
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24367631
45GATA3_24758297_ChIP-Seq_MCF-7_Human1.23267796
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22444545
47CREB1_26743006_Chip-Seq_LNCaP_Human1.22282547
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21053447
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20930545
50P68_20966046_ChIP-Seq_HELA_Human1.20610833
51EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18500024
52AHR_22903824_ChIP-Seq_MCF-7_Human1.17832355
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17503066
54SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16799007
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.16128158
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15746112
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.14788181
58TET1_21490601_ChIP-Seq_MESCs_Mouse1.13413258
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.13348196
60* TP63_22573176_ChIP-Seq_HFKS_Human1.12287505
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11070003
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11070003
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10947177
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09888985
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09064561
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08500577
67SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07745808
68* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06947598
69CTCF_26484167_Chip-Seq_Bcells_Mouse1.06314147
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.04898018
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.01512631
72FOXP1_21924763_ChIP-Seq_HESCs_Human1.01383035
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01326997
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00766870
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00721901
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00630444
77DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98861129
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97711399
79KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97632402
80CBX2_27304074_Chip-Seq_ESCs_Mouse0.97374630
81KLF5_25053715_ChIP-Seq_YYC3_Human0.97209867
82PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95285911
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94172697
84SOX3_22085726_ChIP-Seq_NPCs_Mouse0.93103019
85JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93037107
86RING1B_27294783_Chip-Seq_ESCs_Mouse0.91834531
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91791558
88IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91179789
89KDM5A_27292631_Chip-Seq_BREAST_Human0.91122540
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90435343
91MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89329065
92BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88980802
93RARB_24833708_ChIP-Seq_LIVER_Mouse0.87976940
94XRN2_22483619_ChIP-Seq_HELA_Human0.87586778
95CHD1_26751641_Chip-Seq_LNCaP_Human0.87073041
96SOX2_20726797_ChIP-Seq_SW620_Human0.87065591
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85594307
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85529238
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.85003886
100TP53_22127205_ChIP-Seq_IMR90_Human0.84329127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo4.21017426
2MP0010234_abnormal_vibrissa_follicle3.38116646
3MP0000579_abnormal_nail_morphology3.20264168
4MP0000566_synostosis3.15499509
5MP0002796_impaired_skin_barrier2.45339744
6MP0003705_abnormal_hypodermis_morpholog2.43499336
7MP0003941_abnormal_skin_development2.38962373
8MP0002254_reproductive_system_inflammat2.38458879
9MP0004264_abnormal_extraembryonic_tissu2.35270686
10MP0002909_abnormal_adrenal_gland2.08912354
11MP0005248_abnormal_Harderian_gland2.04930934
12MP0002653_abnormal_ependyma_morphology2.01509949
13MP0001881_abnormal_mammary_gland1.98608161
14MP0005501_abnormal_skin_physiology1.93537100
15MP0002098_abnormal_vibrissa_morphology1.91593305
16MP0009379_abnormal_foot_pigmentation1.89369786
17MP0003787_abnormal_imprinting1.85021820
18MP0009053_abnormal_anal_canal1.84694055
19MP0004133_heterotaxia1.83131767
20MP0010030_abnormal_orbit_morphology1.81324638
21MP0005379_endocrine/exocrine_gland_phen1.73414869
22MP0000383_abnormal_hair_follicle1.72564338
23MP0005083_abnormal_biliary_tract1.71610323
24MP0001944_abnormal_pancreas_morphology1.66215219
25MP0002163_abnormal_gland_morphology1.62326804
26MP0005257_abnormal_intraocular_pressure1.61610028
27MP0003011_delayed_dark_adaptation1.57551388
28MP0004858_abnormal_nervous_system1.57233690
29MP0003123_paternal_imprinting1.57076255
30MP0010678_abnormal_skin_adnexa1.55188194
31MP0000427_abnormal_hair_cycle1.41165103
32MP0003942_abnormal_urinary_system1.34845823
33MP0000003_abnormal_adipose_tissue1.33709932
34MP0000762_abnormal_tongue_morphology1.33686727
35MP0005646_abnormal_pituitary_gland1.33526314
36MP0000627_abnormal_mammary_gland1.33332668
37MP0000377_abnormal_hair_follicle1.31609650
38MP0003136_yellow_coat_color1.30806772
39MP0002837_dystrophic_cardiac_calcinosis1.30562455
40MP0001958_emphysema1.28843714
41MP0004019_abnormal_vitamin_homeostasis1.28688422
42MP0002060_abnormal_skin_morphology1.26357805
43MP0002249_abnormal_larynx_morphology1.25851756
44MP0003878_abnormal_ear_physiology1.17204733
45MP0005377_hearing/vestibular/ear_phenot1.17204733
46MP0005503_abnormal_tendon_morphology1.16550285
47MP0005409_darkened_coat_color1.16310313
48MP0000467_abnormal_esophagus_morphology1.15451950
49MP0010771_integument_phenotype1.09140200
50MP0001216_abnormal_epidermal_layer1.08917903
51MP0003453_abnormal_keratinocyte_physiol1.08891606
52MP0000462_abnormal_digestive_system1.08392513
53MP0004782_abnormal_surfactant_physiolog1.08324262
54MP0009384_cardiac_valve_regurgitation1.07494696
55MP0003938_abnormal_ear_development1.05896858
56MP0000013_abnormal_adipose_tissue1.05625194
57MP0003755_abnormal_palate_morphology1.03507999
58MP0001529_abnormal_vocalization1.01987422
59MP0003936_abnormal_reproductive_system1.01396271
60MP0004381_abnormal_hair_follicle1.01294020
61MP0001919_abnormal_reproductive_system1.00718942
62MP0000534_abnormal_ureter_morphology0.98711028
63MP0002876_abnormal_thyroid_physiology0.95322969
64MP0000631_abnormal_neuroendocrine_gland0.94951213
65MP0008438_abnormal_cutaneous_collagen0.94383135
66MP0000537_abnormal_urethra_morphology0.94304509
67MP0005275_abnormal_skin_tensile0.93414868
68MP0000778_abnormal_nervous_system0.92326506
69MP0003122_maternal_imprinting0.91442050
70MP0001340_abnormal_eyelid_morphology0.91183724
71MP0000470_abnormal_stomach_morphology0.91111403
72MP0002697_abnormal_eye_size0.88336881
73MP0001849_ear_inflammation0.82298730
74MP0002184_abnormal_innervation0.81766782
75MP0003183_abnormal_peptide_metabolism0.80888948
76MP0000538_abnormal_urinary_bladder0.80617023
77MP0003879_abnormal_hair_cell0.79034188
78MP0001243_abnormal_dermal_layer0.79021963
79MP0002116_abnormal_craniofacial_bone0.78845175
80MP0004270_analgesia0.77412899
81MP0000750_abnormal_muscle_regeneration0.76791658
82MP0009672_abnormal_birth_weight0.76029834
83MP0002938_white_spotting0.74713193
84MP0005645_abnormal_hypothalamus_physiol0.74503257
85MP0001299_abnormal_eye_distance/0.74497476
86MP0002822_catalepsy0.74197784
87MP0001984_abnormal_olfaction0.74090072
88MP0003283_abnormal_digestive_organ0.74020005
89MP0000647_abnormal_sebaceous_gland0.71612602
90MP0003638_abnormal_response/metabolism_0.70606381
91MP0003959_abnormal_lean_body0.69828940
92MP0005508_abnormal_skeleton_morphology0.69603541
93MP0000613_abnormal_salivary_gland0.69076044
94MP0005375_adipose_tissue_phenotype0.68915441
95MP0002693_abnormal_pancreas_physiology0.67774661
96MP0000678_abnormal_parathyroid_gland0.67056945
97MP0002108_abnormal_muscle_morphology0.66266647
98MP0000049_abnormal_middle_ear0.65960719
99MP0006072_abnormal_retinal_apoptosis0.65174826
100MP0001502_abnormal_circadian_rhythm0.64684885

Predicted human phenotypes

RankGene SetZ-score
1Enlarged penis (HP:0000040)4.16602153
2Pili torti (HP:0003777)3.32803504
3Concave nail (HP:0001598)3.20065406
4J-shaped sella turcica (HP:0002680)3.19964088
5Sparse lateral eyebrow (HP:0005338)3.15578719
6Septate vagina (HP:0001153)3.15344620
7Long toe (HP:0010511)3.11285401
8Amelogenesis imperfecta (HP:0000705)2.97003330
9Congenital malformation of the right heart (HP:0011723)2.96452228
10Double outlet right ventricle (HP:0001719)2.96452228
11Macroorchidism (HP:0000053)2.66963747
12Hyperthyroidism (HP:0000836)2.65802861
13Abnormal hair laboratory examination (HP:0003328)2.48334118
14Hyperacusis (HP:0010780)2.46683229
15Renal salt wasting (HP:0000127)2.45724999
16Obstructive sleep apnea (HP:0002870)2.43012813
17Hyperparathyroidism (HP:0000843)2.41181714
18Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.39860931
19Down-sloping shoulders (HP:0200021)2.37732586
20Congenital glaucoma (HP:0001087)2.35039167
21Abnormality of the aortic arch (HP:0012303)2.29837952
22Hyperphosphatemia (HP:0002905)2.23219900
23Oligodactyly (HP:0012165)2.15145550
24Cardiomegaly (HP:0001640)2.11037543
25Oligodactyly (hands) (HP:0001180)2.08364338
26Abnormality of the Achilles tendon (HP:0005109)2.08255096
27Hypercortisolism (HP:0001578)2.07862560
28Achilles tendon contracture (HP:0001771)2.05543412
29Cervical subluxation (HP:0003308)2.04430051
30Hypoplasia of dental enamel (HP:0006297)2.03107629
31Hypokinesia (HP:0002375)2.00261839
32Nasolacrimal duct obstruction (HP:0000579)1.98220460
33Abnormality of the dental root (HP:0006486)1.98012912
34Taurodontia (HP:0000679)1.98012912
35Abnormality of permanent molar morphology (HP:0011071)1.98012912
36Abnormality of molar morphology (HP:0011070)1.95428864
37Abnormality of molar (HP:0011077)1.95428864
38Hypotrichosis (HP:0001006)1.94419732
39Partial duplication of thumb phalanx (HP:0009944)1.92544661
40Abnormality of the diencephalon (HP:0010662)1.90957404
41Patellar dislocation (HP:0002999)1.86866080
42Overriding aorta (HP:0002623)1.85987751
43Sleep apnea (HP:0010535)1.84554546
44Abnormality of the 2nd finger (HP:0004100)1.83911648
45Mitral regurgitation (HP:0001653)1.83869112
46Buphthalmos (HP:0000557)1.82856973
47Elfin facies (HP:0004428)1.82457316
48Growth hormone excess (HP:0000845)1.82353969
49Hand muscle atrophy (HP:0009130)1.82095805
50Vascular calcification (HP:0004934)1.81360180
51Split foot (HP:0001839)1.81048102
52Partial duplication of the phalanx of hand (HP:0009999)1.80751664
53Hypoparathyroidism (HP:0000829)1.80675140
54Coronal craniosynostosis (HP:0004440)1.80179412
55Shawl scrotum (HP:0000049)1.79545733
56Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79469115
57Abnormality of the dental pulp (HP:0006479)1.79317125
58Right ventricular cardiomyopathy (HP:0011663)1.78578720
59Septo-optic dysplasia (HP:0100842)1.78185751
60Infantile muscular hypotonia (HP:0008947)1.76937611
61Abdominal distention (HP:0003270)1.76592680
62Advanced eruption of teeth (HP:0006288)1.75981189
63Agitation (HP:0000713)1.74393091
64Urinary glycosaminoglycan excretion (HP:0003541)1.73371165
65Mucopolysacchariduria (HP:0008155)1.73371165
66Hyperactive renin-angiotensin system (HP:0000841)1.72403111
67Flat acetabular roof (HP:0003180)1.71250433
68Bronchomalacia (HP:0002780)1.68135453
69Slender long bone (HP:0003100)1.68089065
70Acute necrotizing encephalopathy (HP:0006965)1.67166576
71Curly hair (HP:0002212)1.65170241
72Upper limb amyotrophy (HP:0009129)1.63609321
73Distal upper limb amyotrophy (HP:0007149)1.63609321
74Abnormality of the lacrimal duct (HP:0011481)1.63512422
75Turricephaly (HP:0000262)1.63185973
76Deformed sella turcica (HP:0002681)1.63062287
77Poor suck (HP:0002033)1.62586130
78Woolly hair (HP:0002224)1.62262653
79Fragile nails (HP:0001808)1.61289752
80Nuclear cataract (HP:0100018)1.61129511
81Shallow orbits (HP:0000586)1.60991340
82Abnormality of aromatic amino acid family metabolism (HP:0004338)1.60341489
83Cardiovascular calcification (HP:0011915)1.59868302
84Asymmetry of the thorax (HP:0001555)1.59842162
85Abnormality of dentin (HP:0010299)1.59631540
86Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.59563166
87Vertebral hypoplasia (HP:0008417)1.59563166
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.59238699
89Atrophic scars (HP:0001075)1.57691029
90Abnormality of calcium-phosphate metabolism (HP:0100530)1.57550847
91Preauricular skin tag (HP:0000384)1.56964681
92Abnormality of glycosaminoglycan metabolism (HP:0004371)1.56917624
93Abnormality of mucopolysaccharide metabolism (HP:0011020)1.56917624
94Abnormality of polysaccharide metabolism (HP:0011012)1.56917624
95Humeroradial synostosis (HP:0003041)1.56405216
96Synostosis involving the elbow (HP:0003938)1.56405216
97Testicular atrophy (HP:0000029)1.56117445
98Deviation of the hallux (HP:0010051)1.55587367
99Lip pit (HP:0100267)1.54002350
100Abnormality of the parietal bone (HP:0002696)1.53385798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK14.29199401
2EPHA24.25336675
3TRIB33.57010633
4PIM23.26651684
5PKN22.88366240
6MUSK2.77843034
7TESK12.42011894
8CASK2.31495745
9NME22.25626897
10ARAF2.24681946
11MAP3K92.10386729
12PRKD32.09336362
13VRK21.88337628
14MAPKAPK31.88058419
15RPS6KB21.81398004
16LATS21.80102491
17PHKG21.72317370
18PHKG11.72317370
19PTK21.65832023
20PRKCI1.65721556
21MAPK151.64565552
22ILK1.60831115
23SMG11.49638935
24ABL21.49574556
25IRAK31.47513821
26STK31.39980774
27PRKD21.26636216
28EPHB21.25144769
29IRAK21.24793664
30MAP2K21.22533123
31LRRK21.21524650
32DYRK1B1.21051613
33LATS11.20405346
34STK381.18167237
35BRAF1.05567951
36MTOR1.04850871
37CAMK2G1.03035861
38CHUK1.01960582
39LIMK10.99476026
40PTK60.97882963
41STK38L0.96333244
42CDK80.95002618
43CAMK2D0.89778068
44GRK10.89722297
45NTRK10.85196215
46EEF2K0.84744420
47RPS6KA20.83167285
48FGFR40.82457216
49DAPK30.80940756
50MET0.80706128
51FGFR20.79867469
52MAP3K120.78708662
53TAOK10.77473316
54PAK40.77106278
55NME10.74922105
56MAP2K70.74510917
57MAP2K60.73783457
58CAMK2B0.73113057
59TAF10.68161429
60EPHB10.66536281
61SIK30.61244992
62ERN10.57886307
63MARK20.57679701
64RPS6KA40.57336776
65FER0.55313796
66DYRK20.54612427
67CSNK1A10.54378773
68DYRK30.51435615
69BCKDK0.51378347
70MAP2K10.51362261
71MST1R0.51068010
72CDC42BPA0.50954223
73PRKD10.48912374
74LMTK20.48796509
75CDK70.45750452
76STK240.45676141
77TGFBR10.45169200
78HIPK20.44431905
79PAK20.43384360
80BMX0.42290255
81MYLK0.39735791
82MAP3K40.37558655
83PDPK10.37353935
84RIPK10.36812725
85MAP2K40.35905169
86TYRO30.35716190
87BRSK10.34926006
88PDGFRA0.34302871
89IRAK10.34231326
90PAK30.33773279
91ROCK20.33168529
92DAPK20.32055247
93RPS6KL10.31262219
94RPS6KC10.31262219
95MAP4K20.30592192
96STK160.29758419
97CSNK1E0.29562836
98PRKCZ0.29364040
99AKT20.29231599
100PDGFRB0.29140734

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.59292698
2Vitamin B6 metabolism_Homo sapiens_hsa007502.85960158
3Notch signaling pathway_Homo sapiens_hsa043302.56746174
4Ribosome_Homo sapiens_hsa030102.50170246
5Folate biosynthesis_Homo sapiens_hsa007902.21309812
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17837485
7Oxidative phosphorylation_Homo sapiens_hsa001901.96825497
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.96462458
9Vibrio cholerae infection_Homo sapiens_hsa051101.69549817
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.65091551
11Hippo signaling pathway_Homo sapiens_hsa043901.65052759
12Galactose metabolism_Homo sapiens_hsa000521.64968060
13Basal cell carcinoma_Homo sapiens_hsa052171.61953229
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48642872
15Tight junction_Homo sapiens_hsa045301.45410847
16Bladder cancer_Homo sapiens_hsa052191.38453582
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25537110
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.24934667
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23573757
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19050959
21Glutathione metabolism_Homo sapiens_hsa004801.16965110
22Axon guidance_Homo sapiens_hsa043601.15697794
23Insulin secretion_Homo sapiens_hsa049111.14275793
24Hedgehog signaling pathway_Homo sapiens_hsa043401.12825963
25Huntingtons disease_Homo sapiens_hsa050161.12122144
26Caffeine metabolism_Homo sapiens_hsa002321.11614988
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11517076
28Alzheimers disease_Homo sapiens_hsa050101.09112278
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08462345
30Steroid biosynthesis_Homo sapiens_hsa001001.07813157
31Sulfur metabolism_Homo sapiens_hsa009201.04846394
32Melanogenesis_Homo sapiens_hsa049161.02170785
33Parkinsons disease_Homo sapiens_hsa050120.99536796
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98618229
35Endometrial cancer_Homo sapiens_hsa052130.98420177
36Glucagon signaling pathway_Homo sapiens_hsa049220.97404420
37N-Glycan biosynthesis_Homo sapiens_hsa005100.95838559
38ErbB signaling pathway_Homo sapiens_hsa040120.94810604
39Collecting duct acid secretion_Homo sapiens_hsa049660.94763648
40Cardiac muscle contraction_Homo sapiens_hsa042600.94620855
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90255710
42AMPK signaling pathway_Homo sapiens_hsa041520.86145695
43Melanoma_Homo sapiens_hsa052180.85368368
44Synaptic vesicle cycle_Homo sapiens_hsa047210.84748409
45Glycosaminoglycan degradation_Homo sapiens_hsa005310.84256526
46Insulin signaling pathway_Homo sapiens_hsa049100.83834171
47Sphingolipid metabolism_Homo sapiens_hsa006000.82855250
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82778917
49Fatty acid biosynthesis_Homo sapiens_hsa000610.80125165
50Pentose phosphate pathway_Homo sapiens_hsa000300.79741714
51Selenocompound metabolism_Homo sapiens_hsa004500.78138620
52Fructose and mannose metabolism_Homo sapiens_hsa000510.77936328
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77787473
54Arginine biosynthesis_Homo sapiens_hsa002200.74679256
55Phenylalanine metabolism_Homo sapiens_hsa003600.74387774
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72404953
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72328210
58beta-Alanine metabolism_Homo sapiens_hsa004100.71775086
59Lysosome_Homo sapiens_hsa041420.69403531
60Thyroid cancer_Homo sapiens_hsa052160.67182929
61Proteoglycans in cancer_Homo sapiens_hsa052050.65523720
62Renal cell carcinoma_Homo sapiens_hsa052110.65033814
63Metabolic pathways_Homo sapiens_hsa011000.64910092
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64356800
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.64080956
66Tyrosine metabolism_Homo sapiens_hsa003500.62243623
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62203442
68Estrogen signaling pathway_Homo sapiens_hsa049150.61918518
69ECM-receptor interaction_Homo sapiens_hsa045120.59868058
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58165240
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58131630
72Prolactin signaling pathway_Homo sapiens_hsa049170.57906750
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55947266
74Peroxisome_Homo sapiens_hsa041460.54579549
75Other glycan degradation_Homo sapiens_hsa005110.54398346
76Fatty acid elongation_Homo sapiens_hsa000620.54047264
77VEGF signaling pathway_Homo sapiens_hsa043700.53971492
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52900476
79Wnt signaling pathway_Homo sapiens_hsa043100.52886860
80Prostate cancer_Homo sapiens_hsa052150.51375437
81Cocaine addiction_Homo sapiens_hsa050300.50658179
82RNA polymerase_Homo sapiens_hsa030200.49711684
83Dilated cardiomyopathy_Homo sapiens_hsa054140.49351629
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48911925
85Insulin resistance_Homo sapiens_hsa049310.47160412
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.47001248
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.46624521
88Inositol phosphate metabolism_Homo sapiens_hsa005620.46607607
89Adherens junction_Homo sapiens_hsa045200.46132172
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44850590
91TGF-beta signaling pathway_Homo sapiens_hsa043500.44254409
92Ovarian steroidogenesis_Homo sapiens_hsa049130.43500217
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39563446
94Hepatitis C_Homo sapiens_hsa051600.39556533
95Long-term depression_Homo sapiens_hsa047300.38631428
96Focal adhesion_Homo sapiens_hsa045100.38043137
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36466258
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36067829
99Dopaminergic synapse_Homo sapiens_hsa047280.33898096
100Chemical carcinogenesis_Homo sapiens_hsa052040.32684338

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