Rank | Gene Set | Z-score |
---|---|---|
1 | negative regulation of cell killing (GO:0031342) | 5.26560394 |
2 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.26560394 |
3 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.09033985 |
4 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.04020689 |
5 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.61286640 |
6 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 4.56242953 |
7 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.52981591 |
8 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.52981591 |
9 | modulation by symbiont of host immune response (GO:0052553) | 4.52981591 |
10 | positive regulation by symbiont of host defense response (GO:0052509) | 4.52981591 |
11 | modulation by symbiont of host defense response (GO:0052031) | 4.52981591 |
12 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.52981591 |
13 | detection of molecule of bacterial origin (GO:0032490) | 4.26600622 |
14 | response to peptidoglycan (GO:0032494) | 4.25914601 |
15 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 4.15200012 |
16 | cellular extravasation (GO:0045123) | 4.05551952 |
17 | regulation of gamma-delta T cell activation (GO:0046643) | 3.96977707 |
18 | negative regulation of interleukin-12 production (GO:0032695) | 3.95073581 |
19 | microglial cell activation (GO:0001774) | 3.86828695 |
20 | macrophage activation involved in immune response (GO:0002281) | 3.86775962 |
21 | neutrophil activation involved in immune response (GO:0002283) | 3.86273253 |
22 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.82783764 |
23 | protein targeting to Golgi (GO:0000042) | 3.78792620 |
24 | negative regulation of T cell mediated immunity (GO:0002710) | 3.77769121 |
25 | establishment of protein localization to Golgi (GO:0072600) | 3.68922712 |
26 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.65284135 |
27 | neutrophil activation (GO:0042119) | 3.60794362 |
28 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.60469927 |
29 | response to interleukin-15 (GO:0070672) | 3.49717018 |
30 | neutrophil mediated immunity (GO:0002446) | 3.46935882 |
31 | defense response to protozoan (GO:0042832) | 3.45788001 |
32 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 3.45158639 |
33 | single strand break repair (GO:0000012) | 3.44255076 |
34 | histone H3-K36 demethylation (GO:0070544) | 3.43596514 |
35 | detection of other organism (GO:0098543) | 3.41598702 |
36 | cellular response to interleukin-15 (GO:0071350) | 3.41052765 |
37 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.35906625 |
38 | response to host immune response (GO:0052572) | 3.35906625 |
39 | detection of external biotic stimulus (GO:0098581) | 3.35291686 |
40 | sperm motility (GO:0030317) | 3.30605892 |
41 | histone H3-K9 demethylation (GO:0033169) | 3.27467251 |
42 | granulocyte activation (GO:0036230) | 3.27378246 |
43 | myeloid cell activation involved in immune response (GO:0002275) | 3.22953465 |
44 | histone mRNA catabolic process (GO:0071044) | 3.20146016 |
45 | macrophage activation (GO:0042116) | 3.19539604 |
46 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.18420133 |
47 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 3.15808446 |
48 | myeloid leukocyte mediated immunity (GO:0002444) | 3.10719784 |
49 | response to protozoan (GO:0001562) | 3.08918171 |
50 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.08035385 |
51 | negative T cell selection (GO:0043383) | 3.07437142 |
52 | negative regulation of cAMP-mediated signaling (GO:0043951) | 3.06017081 |
53 | negative thymic T cell selection (GO:0045060) | 3.04473800 |
54 | leukocyte aggregation (GO:0070486) | 3.02239590 |
55 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.02032031 |
56 | detection of biotic stimulus (GO:0009595) | 3.01799157 |
57 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.97652152 |
58 | negative regulation of inclusion body assembly (GO:0090084) | 2.96985916 |
59 | positive T cell selection (GO:0043368) | 2.93591571 |
60 | positive regulation of granulocyte differentiation (GO:0030854) | 2.92224363 |
61 | negative regulation of interleukin-1 beta production (GO:0032691) | 2.91465318 |
62 | regulation of interleukin-6 biosynthetic process (GO:0045408) | 2.90013171 |
63 | response to host (GO:0075136) | 2.88634045 |
64 | response to host defenses (GO:0052200) | 2.88634045 |
65 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.88634045 |
66 | DNA methylation involved in gamete generation (GO:0043046) | 2.87242813 |
67 | respiratory burst (GO:0045730) | 2.87142835 |
68 | response to muramyl dipeptide (GO:0032495) | 2.85412300 |
69 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.85190015 |
70 | acrosome reaction (GO:0007340) | 2.84933195 |
71 | negative regulation of leukocyte mediated immunity (GO:0002704) | 2.84245515 |
72 | male meiosis I (GO:0007141) | 2.84102162 |
73 | interferon-gamma production (GO:0032609) | 2.82929949 |
74 | B cell receptor signaling pathway (GO:0050853) | 2.82569676 |
75 | regulation of memory T cell differentiation (GO:0043380) | 2.82556312 |
76 | mast cell activation (GO:0045576) | 2.81493825 |
77 | positive thymic T cell selection (GO:0045059) | 2.80533653 |
78 | detection of bacterium (GO:0016045) | 2.79612719 |
79 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 2.78501649 |
80 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 2.75088669 |
81 | negative regulation of adaptive immune response (GO:0002820) | 2.73259477 |
82 | negative regulation of interleukin-1 production (GO:0032692) | 2.73250337 |
83 | tyrosine phosphorylation of STAT protein (GO:0007260) | 2.71694180 |
84 | type I interferon signaling pathway (GO:0060337) | 2.71394999 |
85 | cellular response to type I interferon (GO:0071357) | 2.71394999 |
86 | protein K48-linked deubiquitination (GO:0071108) | 2.69760145 |
87 | fusion of sperm to egg plasma membrane (GO:0007342) | 2.69724554 |
88 | positive regulation of B cell differentiation (GO:0045579) | 2.69456965 |
89 | cilium or flagellum-dependent cell motility (GO:0001539) | 2.68912220 |
90 | positive regulation of mast cell activation (GO:0033005) | 2.68176365 |
91 | regulation of T cell mediated cytotoxicity (GO:0001914) | 2.67706108 |
92 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.67528502 |
93 | regulation of B cell differentiation (GO:0045577) | 2.67248106 |
94 | regulation of meiosis I (GO:0060631) | 2.67246204 |
95 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.66570623 |
96 | response to type I interferon (GO:0034340) | 2.66418108 |
97 | leukocyte degranulation (GO:0043299) | 2.64789736 |
98 | immunoglobulin mediated immune response (GO:0016064) | 2.63708003 |
99 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.62807264 |
100 | piRNA metabolic process (GO:0034587) | 2.62634131 |
Rank | Gene Set | Z-score |
---|---|---|
1 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 4.50241004 |
2 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.36060864 |
3 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.01206212 |
4 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.63128326 |
5 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.55804486 |
6 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.48683596 |
7 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.33338092 |
8 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 3.01690855 |
9 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.79570531 |
10 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.70563357 |
11 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.61555071 |
12 | MYB_26560356_Chip-Seq_TH2_Human | 2.52994377 |
13 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.38323860 |
14 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.30038507 |
15 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.26908129 |
16 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.17166140 |
17 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 2.11023119 |
18 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.11023119 |
19 | VDR_24787735_ChIP-Seq_THP-1_Human | 2.05662865 |
20 | MYB_26560356_Chip-Seq_TH1_Human | 1.98255530 |
21 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.97787157 |
22 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.95107818 |
23 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.90622563 |
24 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.89006824 |
25 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.85902266 |
26 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.85254942 |
27 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.77284236 |
28 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.75392671 |
29 | SPI1_23127762_ChIP-Seq_K562_Human | 1.72981968 |
30 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.67654796 |
31 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.62648044 |
32 | GATA3_26560356_Chip-Seq_TH2_Human | 1.61754434 |
33 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.59846557 |
34 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.59677319 |
35 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.59635850 |
36 | MAF_26560356_Chip-Seq_TH1_Human | 1.48621782 |
37 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.43273455 |
38 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.38111172 |
39 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.37648225 |
40 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.35716782 |
41 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.35532725 |
42 | UTX_26944678_Chip-Seq_JUKART_Human | 1.35155898 |
43 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.34201236 |
44 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.33994071 |
45 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.32120299 |
46 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 1.31105622 |
47 | * PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.29162340 |
48 | SMRT_27268052_Chip-Seq_Bcells_Human | 1.28764902 |
49 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.25880439 |
50 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.25056830 |
51 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.18108206 |
52 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.18108206 |
53 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.11512633 |
54 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.10725469 |
55 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08952754 |
56 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.08606485 |
57 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.07773383 |
58 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.06039841 |
59 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.05722663 |
60 | GATA1_19941826_ChIP-Seq_K562_Human | 1.04542446 |
61 | * TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.02622749 |
62 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.02603624 |
63 | * NANOG_20526341_ChIP-Seq_ESCs_Human | 1.01672961 |
64 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.01127712 |
65 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.00713404 |
66 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 1.00682064 |
67 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.00645162 |
68 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.99439031 |
69 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.98625601 |
70 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.96113566 |
71 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.95546415 |
72 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.95351828 |
73 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.94648639 |
74 | GATA3_26560356_Chip-Seq_TH1_Human | 0.94369836 |
75 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 0.93917760 |
76 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.93487429 |
77 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.91263540 |
78 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.91116464 |
79 | * TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.89997489 |
80 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.88560538 |
81 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.87468957 |
82 | MAF_26560356_Chip-Seq_TH2_Human | 0.86683944 |
83 | * SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.86231132 |
84 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.85918179 |
85 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85151630 |
86 | KDM2B_26808549_Chip-Seq_REH_Human | 0.84072854 |
87 | OCT1_27270436_Chip-Seq_PROSTATE_Human | 0.83098602 |
88 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.83084375 |
89 | * TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.82733407 |
90 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.82732446 |
91 | TCF4_23295773_ChIP-Seq_U87_Human | 0.81745102 |
92 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.81414581 |
93 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.79805614 |
94 | STAT3_23295773_ChIP-Seq_U87_Human | 0.78134244 |
95 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.78104618 |
96 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.77696313 |
97 | GATA2_19941826_ChIP-Seq_K562_Human | 0.77570524 |
98 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.77444165 |
99 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.76988454 |
100 | P300_19829295_ChIP-Seq_ESCs_Human | 0.75410501 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003724_increased_susceptibility_to | 4.16596312 |
2 | MP0003303_peritoneal_inflammation | 3.64940816 |
3 | MP0000569_abnormal_digit_pigmentation | 3.58539752 |
4 | MP0001835_abnormal_antigen_presentation | 3.02546285 |
5 | MP0005410_abnormal_fertilization | 3.02345234 |
6 | MP0003436_decreased_susceptibility_to | 2.93322015 |
7 | MP0008057_abnormal_DNA_replication | 2.90890479 |
8 | MP0002822_catalepsy | 2.77963387 |
9 | MP0008877_abnormal_DNA_methylation | 2.75665325 |
10 | MP0005671_abnormal_response_to | 2.75416218 |
11 | MP0001800_abnormal_humoral_immune | 2.57343818 |
12 | MP0003763_abnormal_thymus_physiology | 2.46583645 |
13 | MP0002723_abnormal_immune_serum | 2.39667994 |
14 | MP0005000_abnormal_immune_tolerance | 2.29646928 |
15 | MP0002419_abnormal_innate_immunity | 2.26880536 |
16 | MP0009785_altered_susceptibility_to | 2.24988401 |
17 | MP0005025_abnormal_response_to | 2.15132445 |
18 | MP0006082_CNS_inflammation | 2.15070019 |
19 | MP0005310_abnormal_salivary_gland | 2.14253797 |
20 | MP0002420_abnormal_adaptive_immunity | 2.13083329 |
21 | MP0000685_abnormal_immune_system | 2.10749156 |
22 | MP0001819_abnormal_immune_cell | 2.08796235 |
23 | MP0002452_abnormal_antigen_presenting | 2.08380851 |
24 | MP0002148_abnormal_hypersensitivity_rea | 2.06892565 |
25 | MP0001790_abnormal_immune_system | 1.95584217 |
26 | MP0005387_immune_system_phenotype | 1.95584217 |
27 | MP0009764_decreased_sensitivity_to | 1.90439125 |
28 | MP0002398_abnormal_bone_marrow | 1.84633804 |
29 | MP0003828_pulmonary_edema | 1.77639484 |
30 | MP0005464_abnormal_platelet_physiology | 1.74116981 |
31 | MP0001984_abnormal_olfaction | 1.69500248 |
32 | MP0009278_abnormal_bone_marrow | 1.68673577 |
33 | MP0000716_abnormal_immune_system | 1.68411711 |
34 | MP0003787_abnormal_imprinting | 1.67454036 |
35 | MP0003183_abnormal_peptide_metabolism | 1.62572429 |
36 | MP0002405_respiratory_system_inflammati | 1.62455128 |
37 | MP0002132_abnormal_respiratory_system | 1.61951707 |
38 | MP0008260_abnormal_autophagy | 1.58461260 |
39 | MP0002722_abnormal_immune_system | 1.52958513 |
40 | MP0003698_abnormal_male_reproductive | 1.48195288 |
41 | MP0000703_abnormal_thymus_morphology | 1.45331929 |
42 | MP0001929_abnormal_gametogenesis | 1.43306090 |
43 | MP0005075_abnormal_melanosome_morpholog | 1.43144090 |
44 | MP0000689_abnormal_spleen_morphology | 1.42999080 |
45 | MP0005451_abnormal_body_composition | 1.41072628 |
46 | MP0002332_abnormal_exercise_endurance | 1.36725283 |
47 | MP0000015_abnormal_ear_pigmentation | 1.34635680 |
48 | MP0000465_gastrointestinal_hemorrhage | 1.31902646 |
49 | MP0001845_abnormal_inflammatory_respons | 1.31560940 |
50 | MP0002429_abnormal_blood_cell | 1.29599431 |
51 | MP0003646_muscle_fatigue | 1.27203120 |
52 | MP0004381_abnormal_hair_follicle | 1.26073439 |
53 | MP0009333_abnormal_splenocyte_physiolog | 1.25974983 |
54 | MP0004947_skin_inflammation | 1.24755888 |
55 | MP0003221_abnormal_cardiomyocyte_apopto | 1.24599695 |
56 | MP0001533_abnormal_skeleton_physiology | 1.24288917 |
57 | MP0003656_abnormal_erythrocyte_physiolo | 1.21388901 |
58 | MP0004808_abnormal_hematopoietic_stem | 1.20880347 |
59 | MP0005397_hematopoietic_system_phenotyp | 1.20524913 |
60 | MP0001545_abnormal_hematopoietic_system | 1.20524913 |
61 | MP0004883_abnormal_blood_vessel | 1.16447337 |
62 | MP0002166_altered_tumor_susceptibility | 1.14052466 |
63 | MP0004484_altered_response_of | 1.09783121 |
64 | MP0003300_gastrointestinal_ulcer | 1.09726477 |
65 | MP0010155_abnormal_intestine_physiology | 1.04244667 |
66 | MP0008004_abnormal_stomach_pH | 1.02239771 |
67 | MP0003172_abnormal_lysosome_physiology | 1.01848629 |
68 | MP0002277_abnormal_respiratory_mucosa | 1.01685457 |
69 | MP0002138_abnormal_hepatobiliary_system | 1.00021032 |
70 | MP0008469_abnormal_protein_level | 0.97945622 |
71 | MP0009765_abnormal_xenobiotic_induced | 0.92991138 |
72 | MP0001348_abnormal_lacrimal_gland | 0.91706570 |
73 | MP0001529_abnormal_vocalization | 0.91327733 |
74 | MP0002006_tumorigenesis | 0.91278339 |
75 | MP0003878_abnormal_ear_physiology | 0.90182272 |
76 | MP0005377_hearing/vestibular/ear_phenot | 0.90182272 |
77 | MP0002210_abnormal_sex_determination | 0.86889985 |
78 | MP0003718_maternal_effect | 0.84374098 |
79 | MP0005174_abnormal_tail_pigmentation | 0.83813296 |
80 | MP0002735_abnormal_chemical_nociception | 0.83439106 |
81 | MP0003866_abnormal_defecation | 0.83330263 |
82 | MP0001851_eye_inflammation | 0.82587072 |
83 | MP0005266_abnormal_metabolism | 0.81144452 |
84 | MP0003448_altered_tumor_morphology | 0.77169537 |
85 | MP0005164_abnormal_response_to | 0.76024079 |
86 | MP0000858_altered_metastatic_potential | 0.72607819 |
87 | MP0008874_decreased_physiological_sensi | 0.71360860 |
88 | MP0002998_abnormal_bone_remodeling | 0.71254420 |
89 | MP0002161_abnormal_fertility/fecundity | 0.71248933 |
90 | MP0001853_heart_inflammation | 0.70649974 |
91 | MP0005376_homeostasis/metabolism_phenot | 0.68374423 |
92 | MP0002396_abnormal_hematopoietic_system | 0.66382224 |
93 | MP0000653_abnormal_sex_gland | 0.66260640 |
94 | MP0003045_fibrosis | 0.65911131 |
95 | MP0005167_abnormal_blood-brain_barrier | 0.65419517 |
96 | MP0001145_abnormal_male_reproductive | 0.65084265 |
97 | MP0005645_abnormal_hypothalamus_physiol | 0.64763846 |
98 | MP0008058_abnormal_DNA_repair | 0.63419612 |
99 | MP0005647_abnormal_sex_gland | 0.63008698 |
100 | MP0004142_abnormal_muscle_tone | 0.61436948 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Optic neuritis (HP:0100653) | 5.67515171 |
2 | Retrobulbar optic neuritis (HP:0100654) | 5.67515171 |
3 | Recurrent bacterial skin infections (HP:0005406) | 5.27891008 |
4 | Orchitis (HP:0100796) | 5.27453616 |
5 | Myositis (HP:0100614) | 5.22968030 |
6 | T lymphocytopenia (HP:0005403) | 4.96363732 |
7 | Gastrointestinal infarctions (HP:0005244) | 4.77595636 |
8 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 4.75561719 |
9 | Stomatitis (HP:0010280) | 4.70270936 |
10 | Abnormality of T cell number (HP:0011839) | 4.66761503 |
11 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.55133826 |
12 | Recurrent abscess formation (HP:0002722) | 4.50296051 |
13 | Keratoconjunctivitis sicca (HP:0001097) | 4.32971438 |
14 | Keratoconjunctivitis (HP:0001096) | 4.17840743 |
15 | Eczematoid dermatitis (HP:0000976) | 4.07405709 |
16 | Recurrent fungal infections (HP:0002841) | 3.97431479 |
17 | Recurrent cutaneous fungal infections (HP:0011370) | 3.86148314 |
18 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.86148314 |
19 | Recurrent skin infections (HP:0001581) | 3.82816302 |
20 | Abnormality of macrophages (HP:0004311) | 3.69289469 |
21 | Spontaneous hematomas (HP:0007420) | 3.43274690 |
22 | Encephalitis (HP:0002383) | 3.20556512 |
23 | Arterial thrombosis (HP:0004420) | 3.18412782 |
24 | Hemoptysis (HP:0002105) | 3.14897998 |
25 | Mediastinal lymphadenopathy (HP:0100721) | 3.14869178 |
26 | Leukocytosis (HP:0001974) | 3.11116962 |
27 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.10394563 |
28 | Abnormality of T cells (HP:0002843) | 3.04718131 |
29 | Meningitis (HP:0001287) | 3.04566318 |
30 | Peritonitis (HP:0002586) | 3.02863671 |
31 | Gingivitis (HP:0000230) | 2.98758644 |
32 | Vasculitis (HP:0002633) | 2.97406558 |
33 | Chest pain (HP:0100749) | 2.92196572 |
34 | Autoimmune thrombocytopenia (HP:0001973) | 2.90050454 |
35 | Chronic obstructive pulmonary disease (HP:0006510) | 2.87775891 |
36 | Obstructive lung disease (HP:0006536) | 2.87775891 |
37 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.87233101 |
38 | Autoimmune hemolytic anemia (HP:0001890) | 2.77108174 |
39 | Acute hepatic failure (HP:0006554) | 2.76906230 |
40 | Gangrene (HP:0100758) | 2.73679540 |
41 | Episodic fever (HP:0001954) | 2.70856638 |
42 | Gingival bleeding (HP:0000225) | 2.68564541 |
43 | Attenuation of retinal blood vessels (HP:0007843) | 2.62303565 |
44 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.61646643 |
45 | Absent/shortened dynein arms (HP:0200106) | 2.61646643 |
46 | Recurrent viral infections (HP:0004429) | 2.57531435 |
47 | Hypoplasia of the thymus (HP:0000778) | 2.57523937 |
48 | Pulmonary infiltrates (HP:0002113) | 2.50933943 |
49 | Increased IgE level (HP:0003212) | 2.46752751 |
50 | Anorexia (HP:0002039) | 2.45643092 |
51 | Postural instability (HP:0002172) | 2.44330760 |
52 | Slow saccadic eye movements (HP:0000514) | 2.42511145 |
53 | Pulmonary embolism (HP:0002204) | 2.38892888 |
54 | Keratitis (HP:0000491) | 2.35286703 |
55 | Eosinophilia (HP:0001880) | 2.34372184 |
56 | Amaurosis fugax (HP:0100576) | 2.33385191 |
57 | Inflammation of the large intestine (HP:0002037) | 2.30726608 |
58 | Glomerulopathy (HP:0100820) | 2.22884930 |
59 | Abnormality of eosinophils (HP:0001879) | 2.22500623 |
60 | Urticaria (HP:0001025) | 2.22012780 |
61 | Osteomalacia (HP:0002749) | 2.19909652 |
62 | Polyneuropathy (HP:0001271) | 2.17834388 |
63 | Abnormal spermatogenesis (HP:0008669) | 2.13396309 |
64 | Resting tremor (HP:0002322) | 2.13268661 |
65 | Thyroiditis (HP:0100646) | 2.09286084 |
66 | IgG deficiency (HP:0004315) | 2.08720280 |
67 | Chronic hepatic failure (HP:0100626) | 2.08057366 |
68 | Granulocytopenia (HP:0001913) | 2.07707271 |
69 | Abnormality of the pleura (HP:0002103) | 2.06830071 |
70 | Amyloidosis (HP:0011034) | 2.03333566 |
71 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.03323029 |
72 | Epistaxis (HP:0000421) | 2.03225478 |
73 | Abnormality of the endocardium (HP:0004306) | 2.02944727 |
74 | Abnormality of the peritoneum (HP:0002585) | 2.01672608 |
75 | Vertigo (HP:0002321) | 2.00980278 |
76 | Bony spicule pigmentary retinopathy (HP:0007737) | 1.99952514 |
77 | Gastrointestinal inflammation (HP:0004386) | 1.99729966 |
78 | Truncal obesity (HP:0001956) | 1.98168728 |
79 | Recurrent bronchitis (HP:0002837) | 1.97077773 |
80 | Prolonged bleeding time (HP:0003010) | 1.94603087 |
81 | Abnormality of the fingertips (HP:0001211) | 1.92395624 |
82 | Pustule (HP:0200039) | 1.91259613 |
83 | Severe visual impairment (HP:0001141) | 1.90508122 |
84 | Alveolar cell carcinoma (HP:0006519) | 1.88207471 |
85 | Basal cell carcinoma (HP:0002671) | 1.87835723 |
86 | Abnormality of the columella (HP:0009929) | 1.86930297 |
87 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 1.85903171 |
88 | Abnormality of B cell number (HP:0010975) | 1.84506764 |
89 | Nasal polyposis (HP:0100582) | 1.83465048 |
90 | Conjunctival telangiectasia (HP:0000524) | 1.82757006 |
91 | Hypochromic anemia (HP:0001931) | 1.81767490 |
92 | Colitis (HP:0002583) | 1.81549746 |
93 | Increased IgM level (HP:0003496) | 1.80898434 |
94 | Joint swelling (HP:0001386) | 1.79670372 |
95 | Hematochezia (HP:0002573) | 1.79293282 |
96 | Stomach cancer (HP:0012126) | 1.79075393 |
97 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.77494368 |
98 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 1.76412915 |
99 | Acne (HP:0001061) | 1.74635561 |
100 | Cheilitis (HP:0100825) | 1.74216304 |
Rank | Gene Set | Z-score |
---|---|---|
1 | RIPK4 | 3.62503256 |
2 | DYRK3 | 3.31137594 |
3 | IRAK4 | 3.21324322 |
4 | TXK | 3.05890531 |
5 | IKBKE | 2.79179259 |
6 | MAP4K1 | 2.70336593 |
7 | BLK | 2.42806387 |
8 | IRAK2 | 2.34653734 |
9 | MAP3K6 | 2.30336708 |
10 | IRAK1 | 2.21577515 |
11 | TYK2 | 2.10387351 |
12 | CSK | 1.83139857 |
13 | ADRBK2 | 1.77159075 |
14 | FES | 1.74144564 |
15 | JAK3 | 1.73578735 |
16 | FGR | 1.72975107 |
17 | MAP3K14 | 1.70764312 |
18 | ZAP70 | 1.70203263 |
19 | GRK6 | 1.67267231 |
20 | EPHB1 | 1.67215816 |
21 | PLK4 | 1.64125802 |
22 | GRK7 | 1.57826083 |
23 | MAP3K13 | 1.57040090 |
24 | BMPR2 | 1.55182464 |
25 | SYK | 1.53437462 |
26 | RPS6KA4 | 1.51101960 |
27 | TAOK3 | 1.50414841 |
28 | PIK3CG | 1.42533183 |
29 | MAP2K3 | 1.42131976 |
30 | SGK2 | 1.41200878 |
31 | BTK | 1.32313947 |
32 | WNK1 | 1.28846210 |
33 | FRK | 1.26797086 |
34 | KSR2 | 1.26042079 |
35 | TBK1 | 1.22823763 |
36 | ITK | 1.20180138 |
37 | MAP3K2 | 1.19657815 |
38 | NEK6 | 1.17882359 |
39 | RAF1 | 1.17689760 |
40 | CAMKK2 | 1.15767667 |
41 | JAK2 | 1.14466516 |
42 | TAOK1 | 1.13193281 |
43 | IKBKB | 1.12058922 |
44 | MARK3 | 1.11564815 |
45 | HCK | 1.10374409 |
46 | PTK2B | 1.05699037 |
47 | JAK1 | 1.05231807 |
48 | NLK | 1.02299690 |
49 | PLK2 | 1.00916150 |
50 | TEC | 0.98395266 |
51 | CAMK1G | 0.96220981 |
52 | LCK | 0.95797455 |
53 | STK38 | 0.95452188 |
54 | LYN | 0.94328603 |
55 | MAP3K5 | 0.93257415 |
56 | MAP3K11 | 0.91229700 |
57 | PDK1 | 0.87755703 |
58 | PIM1 | 0.86479699 |
59 | KSR1 | 0.86083094 |
60 | SGK3 | 0.84151078 |
61 | MAP3K1 | 0.81935522 |
62 | CSF1R | 0.77657443 |
63 | TESK2 | 0.76933340 |
64 | SGK494 | 0.76366505 |
65 | SGK223 | 0.76366505 |
66 | YES1 | 0.75685288 |
67 | CAMK4 | 0.74336904 |
68 | ACVR1B | 0.73412113 |
69 | MAP3K4 | 0.70037646 |
70 | MAP3K9 | 0.69056063 |
71 | TNK2 | 0.69027418 |
72 | STK11 | 0.68621356 |
73 | MATK | 0.66272302 |
74 | DYRK1A | 0.65115946 |
75 | KIT | 0.62955790 |
76 | PNCK | 0.62137821 |
77 | PRKG1 | 0.61249068 |
78 | PRPF4B | 0.61015085 |
79 | NTRK3 | 0.60454917 |
80 | MAP3K3 | 0.52333080 |
81 | DYRK1B | 0.52324889 |
82 | PRKCQ | 0.51006319 |
83 | SGK1 | 0.50804256 |
84 | ARAF | 0.47997134 |
85 | NUAK1 | 0.47856863 |
86 | EGFR | 0.47810697 |
87 | PDPK1 | 0.47558239 |
88 | TGFBR2 | 0.47416783 |
89 | RET | 0.47334940 |
90 | FGFR3 | 0.47156248 |
91 | BRD4 | 0.45764377 |
92 | GRK5 | 0.40808334 |
93 | MAP2K4 | 0.39206267 |
94 | HIPK2 | 0.39025039 |
95 | CHUK | 0.37267492 |
96 | ZAK | 0.36233312 |
97 | RPS6KC1 | 0.34332195 |
98 | RPS6KL1 | 0.34332195 |
99 | TESK1 | 0.33427037 |
100 | CAMK1D | 0.32916369 |
Rank | Gene Set | Z-score |
---|---|---|
1 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.87015489 |
2 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.81116398 |
3 | Leishmaniasis_Homo sapiens_hsa05140 | 2.56327975 |
4 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.20848436 |
5 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.19679901 |
6 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.13816871 |
7 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.10425763 |
8 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.09358195 |
9 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.09005551 |
10 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.01457309 |
11 | Tuberculosis_Homo sapiens_hsa05152 | 2.00757284 |
12 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.99963570 |
13 | Measles_Homo sapiens_hsa05162 | 1.93203811 |
14 | Legionellosis_Homo sapiens_hsa05134 | 1.89682548 |
15 | Allograft rejection_Homo sapiens_hsa05330 | 1.81162574 |
16 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.72199437 |
17 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.71824683 |
18 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.71153810 |
19 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.65992984 |
20 | Influenza A_Homo sapiens_hsa05164 | 1.62874245 |
21 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.61682885 |
22 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.60454278 |
23 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.58147683 |
24 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.52090245 |
25 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.48343612 |
26 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.48195265 |
27 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.46550336 |
28 | Malaria_Homo sapiens_hsa05144 | 1.45099864 |
29 | Nicotine addiction_Homo sapiens_hsa05033 | 1.44657622 |
30 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.44540144 |
31 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.38435076 |
32 | Hepatitis B_Homo sapiens_hsa05161 | 1.28299154 |
33 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.28197595 |
34 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.27520789 |
35 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.25886067 |
36 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.24403383 |
37 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.18395921 |
38 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.13427248 |
39 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.13155112 |
40 | Pertussis_Homo sapiens_hsa05133 | 1.05602473 |
41 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.05345847 |
42 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.03566456 |
43 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.98013469 |
44 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.97345919 |
45 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.94747262 |
46 | Platelet activation_Homo sapiens_hsa04611 | 0.94352077 |
47 | Morphine addiction_Homo sapiens_hsa05032 | 0.93093662 |
48 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.90952901 |
49 | Apoptosis_Homo sapiens_hsa04210 | 0.90695136 |
50 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.88233313 |
51 | Olfactory transduction_Homo sapiens_hsa04740 | 0.86210775 |
52 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.85300782 |
53 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.84592627 |
54 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.83502867 |
55 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.82390971 |
56 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.82242653 |
57 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.81990330 |
58 | Viral myocarditis_Homo sapiens_hsa05416 | 0.81974314 |
59 | Hepatitis C_Homo sapiens_hsa05160 | 0.81420482 |
60 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.79571427 |
61 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.76223705 |
62 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.73231989 |
63 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.72690715 |
64 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.71484620 |
65 | Phagosome_Homo sapiens_hsa04145 | 0.70723012 |
66 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.70532506 |
67 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.68629084 |
68 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.67366682 |
69 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.63705565 |
70 | Asthma_Homo sapiens_hsa05310 | 0.63577478 |
71 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.63304214 |
72 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.62557915 |
73 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.61380965 |
74 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.60722487 |
75 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.59094106 |
76 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.56351576 |
77 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.56227206 |
78 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.56098349 |
79 | Salmonella infection_Homo sapiens_hsa05132 | 0.55410151 |
80 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.55164315 |
81 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.55100024 |
82 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.54907049 |
83 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.54490824 |
84 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.54379325 |
85 | Long-term potentiation_Homo sapiens_hsa04720 | 0.53198234 |
86 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.52350154 |
87 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.51600583 |
88 | Shigellosis_Homo sapiens_hsa05131 | 0.50549850 |
89 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.49728370 |
90 | Insulin resistance_Homo sapiens_hsa04931 | 0.49727824 |
91 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.49382393 |
92 | Endometrial cancer_Homo sapiens_hsa05213 | 0.49175838 |
93 | Colorectal cancer_Homo sapiens_hsa05210 | 0.48259692 |
94 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.47504438 |
95 | Taste transduction_Homo sapiens_hsa04742 | 0.46759266 |
96 | Prostate cancer_Homo sapiens_hsa05215 | 0.45173611 |
97 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.43889495 |
98 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.43843581 |
99 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.43664111 |
100 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.42266876 |