ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of protein glycosylation (GO:0060049)	6.16047967
2	dopamine transport (GO:0015872)	5.76612930
3	gamma-aminobutyric acid signaling pathway (GO:0007214)	5.28078605
4	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	5.06491660
5	diol metabolic process (GO:0034311)	5.01020086
6	sphingosine metabolic process (GO:0006670)	4.80604783
7	regulation of response to food (GO:0032095)	4.77497720
8	sphingoid metabolic process (GO:0046519)	4.73362038
9	glutamate secretion (GO:0014047)	4.39446251
10	synaptic vesicle exocytosis (GO:0016079)	4.34153245
11	cellular response to oxygen radical (GO:0071450)	4.20504055
12	removal of superoxide radicals (GO:0019430)	4.20504055
13	cellular response to superoxide (GO:0071451)	4.20504055
14	dopamine biosynthetic process (GO:0042416)	4.18164271
15	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.14732510
16	L-phenylalanine catabolic process (GO:0006559)	4.14732510
17	catecholamine transport (GO:0051937)	4.00142572
18	serotonin metabolic process (GO:0042428)	3.99700809
19	tyrosine metabolic process (GO:0006570)	3.94059625
20	cellular response to leptin stimulus (GO:0044320)	3.89796234
21	neurofilament cytoskeleton organization (GO:0060052)	3.89434806
22	cellular response to nitric oxide (GO:0071732)	3.87363612
23	DNA methylation involved in gamete generation (GO:0043046)	3.81627340
24	phenol-containing compound catabolic process (GO:0019336)	3.80487474
25	positive regulation of potassium ion transmembrane transport (GO:1901381)	3.76465994
26	response to leptin (GO:0044321)	3.74303809
27	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.73863395
28	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	3.72065599
29	positive regulation of meiosis (GO:0045836)	3.71363969
30	cellular response to reactive nitrogen species (GO:1902170)	3.60276833
31	cellular potassium ion homeostasis (GO:0030007)	3.59021166
32	adaptation of signaling pathway (GO:0023058)	3.56997247
33	L-phenylalanine metabolic process (GO:0006558)	3.53209383
34	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.53209383
35	positive regulation of meiotic cell cycle (GO:0051446)	3.47492838
36	glutamate receptor signaling pathway (GO:0007215)	3.47246926
37	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.46647696
38	primary amino compound metabolic process (GO:1901160)	3.45619361
39	neuron-neuron synaptic transmission (GO:0007270)	3.44580900
40	synaptic transmission, glutamatergic (GO:0035249)	3.43566936
41	negative regulation of reactive oxygen species metabolic process (GO:2000378)	3.42395200
42	DNA deamination (GO:0045006)	3.39876704
43	sterol catabolic process (GO:0016127)	3.34569277
44	cholesterol catabolic process (GO:0006707)	3.34569277
45	neurotransmitter biosynthetic process (GO:0042136)	3.33344375
46	regulation of meiosis I (GO:0060631)	3.33332419
47	dopamine metabolic process (GO:0042417)	3.30203829
48	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.29016553
49	astrocyte development (GO:0014002)	3.28794722
50	cellular response to cadmium ion (GO:0071276)	3.24224676
51	negative regulation of appetite (GO:0032099)	3.22372309
52	negative regulation of response to food (GO:0032096)	3.22372309
53	lipopolysaccharide biosynthetic process (GO:0009103)	3.22361057
54	response to oxygen radical (GO:0000305)	3.21687729
55	response to amphetamine (GO:0001975)	3.20229804
56	startle response (GO:0001964)	3.16935852
57	protein localization to synapse (GO:0035418)	3.16571133
58	response to superoxide (GO:0000303)	3.16548161
59	regulation of synaptic vesicle transport (GO:1902803)	3.14380335
60	cellular zinc ion homeostasis (GO:0006882)	3.14048149
61	neuronal action potential propagation (GO:0019227)	3.12943565
62	neurotransmitter secretion (GO:0007269)	3.11151935
63	membrane depolarization during action potential (GO:0086010)	3.10842782
64	activation of protein kinase B activity (GO:0032148)	3.10201580
65	behavioral response to cocaine (GO:0048148)	3.05974288
66	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	3.05879572
67	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	3.04550790
68	regulation of dopamine secretion (GO:0014059)	3.00950465
69	neuronal action potential (GO:0019228)	3.00654389
70	detection of calcium ion (GO:0005513)	2.93740944
71	neurotransmitter metabolic process (GO:0042133)	2.88430233
72	regulation of dopamine metabolic process (GO:0042053)	2.88165870
73	regulation of catecholamine metabolic process (GO:0042069)	2.88165870
74	prepulse inhibition (GO:0060134)	2.86869743
75	negative regulation of necrotic cell death (GO:0060547)	2.86333589
76	regulation of neurotransmitter levels (GO:0001505)	2.86294191
77	zinc ion homeostasis (GO:0055069)	2.85337843
78	regulation of pigment cell differentiation (GO:0050932)	2.84731317
79	behavioral response to nicotine (GO:0035095)	2.84394054
80	relaxation of smooth muscle (GO:0044557)	2.84321111
81	response to histamine (GO:0034776)	2.83747948
82	fear response (GO:0042596)	2.83614477
83	sleep (GO:0030431)	2.83276192
84	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.83079534
85	behavioral defense response (GO:0002209)	2.82625610
86	behavioral fear response (GO:0001662)	2.82625610
87	neurotransmitter transport (GO:0006836)	2.82585175
88	serotonin receptor signaling pathway (GO:0007210)	2.79839400
89	calcium ion-dependent exocytosis (GO:0017156)	2.79271116
90	gamma-aminobutyric acid transport (GO:0015812)	2.78425692
91	ribonucleoprotein complex disassembly (GO:0032988)	2.77623269
92	potassium ion transmembrane transport (GO:0071805)	2.75984340
93	cellular potassium ion transport (GO:0071804)	2.75984340
94	protein-chromophore linkage (GO:0018298)	2.75659503
95	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.74528101
96	positive regulation of potassium ion transport (GO:0043268)	2.74206309
97	aromatic amino acid family metabolic process (GO:0009072)	2.74102016
98	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.72623009
99	central nervous system myelination (GO:0022010)	2.71062852
100	axon ensheathment in central nervous system (GO:0032291)	2.71062852

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.44479351
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.74111202
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.80574286
4	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.72140299
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.69800949
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.67815133
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.66937908
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.58046207
9	AR_21572438_ChIP-Seq_LNCaP_Human	2.48404711
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.36804312
11	VDR_22108803_ChIP-Seq_LS180_Human	2.35521370
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.32495310
13	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.26709732
14	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.20182229
15	REST_21632747_ChIP-Seq_MESCs_Mouse	2.12527800
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06338877
17	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.01683842
18	P300_19829295_ChIP-Seq_ESCs_Human	1.98906206
19	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.98326702
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.93988242
21	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.92336038
22	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.88940225
23	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.86080185
24	FUS_26573619_Chip-Seq_HEK293_Human	1.85713506
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.84111953
26	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.83814743
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.83140305
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.72914861
29	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.72054883
30	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.69526583
31	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.67810193
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.66109937
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.65491106
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.64005853
35	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.63771706
36	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.63546839
37	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.61078540
38	TCF4_23295773_ChIP-Seq_U87_Human	1.60227968
39	STAT3_23295773_ChIP-Seq_U87_Human	1.59740665
40	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.54842965
41	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.54471987
42	RNF2_27304074_Chip-Seq_NSC_Mouse	1.53386123
43	AR_25329375_ChIP-Seq_VCAP_Human	1.53283196
44	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.52225868
45	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.49982963
46	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.49083276
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46494117
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.45688420
49	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.45004569
50	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.44749941
51	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.44749941
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43526973
53	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42657766
54	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.41628737
55	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33819386
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33773762
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33483758
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33483758
59	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.31690403
60	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.28896094
61	ZNF274_21170338_ChIP-Seq_K562_Hela	1.28723545
62	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.28624226
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27333911
64	EWS_26573619_Chip-Seq_HEK293_Human	1.26306586
65	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26139072
66	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.23105832
67	TP53_16413492_ChIP-PET_HCT116_Human	1.22754031
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22528640
69	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.21767981
70	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.20937326
71	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20724616
72	CBP_20019798_ChIP-Seq_JUKART_Human	1.17918341
73	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17918341
74	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17400569
75	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.17400569
76	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.14770098
77	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.12947766
78	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12712739
79	BCAT_22108803_ChIP-Seq_LS180_Human	1.12619224
80	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.12447387
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.11606510
82	AR_19668381_ChIP-Seq_PC3_Human	1.10084430
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08746949
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07674382
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07401241
86	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.06526418
87	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.06443777
88	TCF4_22108803_ChIP-Seq_LS180_Human	1.06170516
89	TP53_18474530_ChIP-ChIP_U2OS_Human	1.05909556
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04640874
91	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.03678753
92	DROSHA_22980978_ChIP-Seq_HELA_Human	1.03286906
93	JUN_21703547_ChIP-Seq_K562_Human	1.03085889
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02733044
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02621141
96	TP53_22573176_ChIP-Seq_HFKS_Human	1.01226563
97	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.00801148
98	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.00399336
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.98832506
100	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.98776922

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	5.01185588
2	MP0005171_absent_coat_pigmentation	3.99468812
3	MP0009046_muscle_twitch	3.73906069
4	MP0003136_yellow_coat_color	3.24189287
5	MP0002653_abnormal_ependyma_morphology	3.12787350
6	MP0000569_abnormal_digit_pigmentation	3.02819765
7	MP0003879_abnormal_hair_cell	2.94750696
8	MP0009745_abnormal_behavioral_response	2.92174240
9	MP0002064_seizures	2.86139881
10	MP0002272_abnormal_nervous_system	2.75262802
11	MP0003635_abnormal_synaptic_transmissio	2.71320507
12	MP0004859_abnormal_synaptic_plasticity	2.47093603
13	MP0001905_abnormal_dopamine_level	2.45801540
14	MP0003045_fibrosis	2.30762050
15	MP0005646_abnormal_pituitary_gland	2.30754580
16	MP0001968_abnormal_touch/_nociception	2.27397808
17	MP0003890_abnormal_embryonic-extraembry	2.17672367
18	MP0001501_abnormal_sleep_pattern	2.11071763
19	MP0008877_abnormal_DNA_methylation	2.05770881
20	MP0002735_abnormal_chemical_nociception	2.03302888
21	MP0001486_abnormal_startle_reflex	1.99968028
22	MP0004147_increased_porphyrin_level	1.96098695
23	MP0008872_abnormal_physiological_respon	1.94385451
24	MP0002063_abnormal_learning/memory/cond	1.93949786
25	MP0004043_abnormal_pH_regulation	1.93936854
26	MP0003880_abnormal_central_pattern	1.90530752
27	MP0002572_abnormal_emotion/affect_behav	1.87838688
28	MP0004885_abnormal_endolymph	1.84636436
29	MP0002736_abnormal_nociception_after	1.75478460
30	MP0005551_abnormal_eye_electrophysiolog	1.71213981
31	MP0003283_abnormal_digestive_organ	1.68239407
32	MP0002733_abnormal_thermal_nociception	1.66996799
33	MP0003646_muscle_fatigue	1.65298557
34	MP0001485_abnormal_pinna_reflex	1.60114975
35	MP0002160_abnormal_reproductive_system	1.57387143
36	MP0001188_hyperpigmentation	1.55714629
37	MP0003787_abnormal_imprinting	1.54926811
38	MP0001970_abnormal_pain_threshold	1.53240707
39	MP0001440_abnormal_grooming_behavior	1.52761195
40	MP0009780_abnormal_chondrocyte_physiolo	1.51520048
41	MP0004270_analgesia	1.49953535
42	MP0002138_abnormal_hepatobiliary_system	1.46925280
43	MP0001984_abnormal_olfaction	1.42107186
44	MP0002876_abnormal_thyroid_physiology	1.34917890
45	MP0000749_muscle_degeneration	1.33617647
46	MP0002067_abnormal_sensory_capabilities	1.29427248
47	MP0010386_abnormal_urinary_bladder	1.28630200
48	MP0005386_behavior/neurological_phenoty	1.28605645
49	MP0004924_abnormal_behavior	1.28605645
50	MP0008569_lethality_at_weaning	1.23484750
51	MP0005670_abnormal_white_adipose	1.22365826
52	MP0000631_abnormal_neuroendocrine_gland	1.22014210
53	MP0002557_abnormal_social/conspecific_i	1.21417182
54	MP0003195_calcinosis	1.20692397
55	MP0002734_abnormal_mechanical_nocicepti	1.20516012
56	MP0006276_abnormal_autonomic_nervous	1.19676398
57	MP0002095_abnormal_skin_pigmentation	1.17932382
58	MP0005174_abnormal_tail_pigmentation	1.15908147
59	MP0003633_abnormal_nervous_system	1.10727080
60	MP0002229_neurodegeneration	1.10468816
61	MP0004742_abnormal_vestibular_system	1.10019696
62	MP0002882_abnormal_neuron_morphology	1.08246289
63	MP0004142_abnormal_muscle_tone	1.04791863
64	MP0003631_nervous_system_phenotype	1.03874652
65	MP0001963_abnormal_hearing_physiology	1.02750401
66	MP0005389_reproductive_system_phenotype	0.99611037
67	MP0000955_abnormal_spinal_cord	0.99435084
68	MP0002909_abnormal_adrenal_gland	0.95928683
69	MP0002066_abnormal_motor_capabilities/c	0.95142632
70	MP0006072_abnormal_retinal_apoptosis	0.89903310
71	MP0003632_abnormal_nervous_system	0.89723343
72	MP0003137_abnormal_impulse_conducting	0.89534380
73	MP0000778_abnormal_nervous_system	0.88066495
74	MP0004811_abnormal_neuron_physiology	0.87071241
75	MP0004233_abnormal_muscle_weight	0.86142318
76	MP0002938_white_spotting	0.85356450
77	MP0004381_abnormal_hair_follicle	0.84818019
78	MP0000427_abnormal_hair_cycle	0.82906311
79	MP0002184_abnormal_innervation	0.81482557
80	MP0006292_abnormal_olfactory_placode	0.81443190
81	MP0006036_abnormal_mitochondrial_physio	0.78428034
82	MP0002752_abnormal_somatic_nervous	0.75161944
83	MP0005253_abnormal_eye_physiology	0.74097533
84	MP0000026_abnormal_inner_ear	0.72300844
85	MP0002234_abnormal_pharynx_morphology	0.72043945
86	MP0001502_abnormal_circadian_rhythm	0.70903425
87	MP0002822_catalepsy	0.69803902
88	MP0008875_abnormal_xenobiotic_pharmacok	0.68284460
89	MP0005085_abnormal_gallbladder_physiolo	0.68084296
90	MP0001664_abnormal_digestion	0.64816809
91	MP0002168_other_aberrant_phenotype	0.64509669
92	MP0004085_abnormal_heartbeat	0.63846942
93	MP0005423_abnormal_somatic_nervous	0.63621942
94	MP0005075_abnormal_melanosome_morpholog	0.62525385
95	MP0002751_abnormal_autonomic_nervous	0.62471826
96	MP0004215_abnormal_myocardial_fiber	0.61948197
97	MP0005636_abnormal_mineral_homeostasis	0.61441006
98	MP0002638_abnormal_pupillary_reflex	0.58769938
99	MP0002152_abnormal_brain_morphology	0.56022486
100	MP0002163_abnormal_gland_morphology	0.55375120

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	8.97390488
2	Focal seizures (HP:0007359)	6.12980605
3	Limb dystonia (HP:0002451)	5.72798066
4	Dialeptic seizures (HP:0011146)	5.52594701
5	Atonic seizures (HP:0010819)	4.83705837
6	Absence seizures (HP:0002121)	4.31828412
7	Febrile seizures (HP:0002373)	4.01248049
8	Acanthocytosis (HP:0001927)	3.72768698
9	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.52774701
10	Generalized tonic-clonic seizures (HP:0002069)	3.47114770
11	Epileptic encephalopathy (HP:0200134)	3.46711182
12	Gaze-evoked nystagmus (HP:0000640)	3.42811932
13	Amelogenesis imperfecta (HP:0000705)	3.35000300
14	Myokymia (HP:0002411)	3.32738037
15	Action tremor (HP:0002345)	3.26502456
16	Pancreatic cysts (HP:0001737)	3.22727229
17	Postural instability (HP:0002172)	3.14982199
18	Clumsiness (HP:0002312)	2.95300296
19	Hyperventilation (HP:0002883)	2.94246191
20	Progressive cerebellar ataxia (HP:0002073)	2.89855827
21	Status epilepticus (HP:0002133)	2.79946156
22	Nephronophthisis (HP:0000090)	2.69749332
23	Pancreatic fibrosis (HP:0100732)	2.62274940
24	Dyskinesia (HP:0100660)	2.56932897
25	Megalencephaly (HP:0001355)	2.54200069
26	Diplopia (HP:0000651)	2.51726121
27	Abnormality of binocular vision (HP:0011514)	2.51726121
28	Abnormality of the renal cortex (HP:0011035)	2.50836725
29	Molar tooth sign on MRI (HP:0002419)	2.48112390
30	Abnormality of midbrain morphology (HP:0002418)	2.48112390
31	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.47203446
32	Ulnar claw (HP:0001178)	2.41991755
33	Parakeratosis (HP:0001036)	2.38378641
34	Epileptiform EEG discharges (HP:0011182)	2.35982162
35	Abnormality of the renal medulla (HP:0100957)	2.35681881
36	Inability to walk (HP:0002540)	2.33302608
37	Volvulus (HP:0002580)	2.29175586
38	Hemiparesis (HP:0001269)	2.21852568
39	Hypokinesia (HP:0002375)	2.21828399
40	Congenital stationary night blindness (HP:0007642)	2.19360368
41	Syncope (HP:0001279)	2.17616240
42	Nonprogressive disorder (HP:0003680)	2.16141624
43	Type II lissencephaly (HP:0007260)	2.15722920
44	Bradykinesia (HP:0002067)	2.14724662
45	Acute necrotizing encephalopathy (HP:0006965)	2.13711166
46	Broad-based gait (HP:0002136)	2.12318775
47	Progressive inability to walk (HP:0002505)	2.11789943
48	Medial flaring of the eyebrow (HP:0010747)	2.06457056
49	Drooling (HP:0002307)	2.02650115
50	Abnormality of macular pigmentation (HP:0008002)	2.01240831
51	Incomplete penetrance (HP:0003829)	2.00721946
52	Opisthotonus (HP:0002179)	1.98769892
53	Truncal ataxia (HP:0002078)	1.98076146
54	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.96725767
55	Progressive macrocephaly (HP:0004481)	1.95110144
56	Pendular nystagmus (HP:0012043)	1.94940666
57	Ventricular fibrillation (HP:0001663)	1.94346097
58	Mitochondrial inheritance (HP:0001427)	1.94212914
59	Colon cancer (HP:0003003)	1.91491671
60	True hermaphroditism (HP:0010459)	1.91152150
61	Renal cortical cysts (HP:0000803)	1.90990922
62	Delayed gross motor development (HP:0002194)	1.89142870
63	Aplastic anemia (HP:0001915)	1.88723169
64	Pigmentary retinal degeneration (HP:0001146)	1.85140614
65	EEG with generalized epileptiform discharges (HP:0011198)	1.84950477
66	Abnormal mitochondria in muscle tissue (HP:0008316)	1.84303151
67	Polydipsia (HP:0001959)	1.83528134
68	Abnormal drinking behavior (HP:0030082)	1.83528134
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.82474908
70	Diminished movement (HP:0002374)	1.81199256
71	Methylmalonic acidemia (HP:0002912)	1.80379970
72	Morphological abnormality of the pyramidal tract (HP:0002062)	1.79993016
73	Hypothermia (HP:0002045)	1.79983646
74	Excessive salivation (HP:0003781)	1.78917131
75	Dysdiadochokinesis (HP:0002075)	1.77910364
76	Cystic liver disease (HP:0006706)	1.73427360
77	Anxiety (HP:0000739)	1.73342693
78	Enlarged kidneys (HP:0000105)	1.71443660
79	Rectal prolapse (HP:0002035)	1.70930558
80	Increased CSF lactate (HP:0002490)	1.69033914
81	Hyperthyroidism (HP:0000836)	1.68875705
82	Decreased circulating renin level (HP:0003351)	1.68256805
83	Acute encephalopathy (HP:0006846)	1.67611530
84	Abnormal eating behavior (HP:0100738)	1.67210024
85	Furrowed tongue (HP:0000221)	1.66935616
86	Torticollis (HP:0000473)	1.66743417
87	Gait imbalance (HP:0002141)	1.65685447
88	Rigidity (HP:0002063)	1.64064687
89	Hypsarrhythmia (HP:0002521)	1.63145465
90	Supranuclear gaze palsy (HP:0000605)	1.61033194
91	Abnormality of renal resorption (HP:0011038)	1.60903692
92	Absent speech (HP:0001344)	1.60542426
93	Birth length less than 3rd percentile (HP:0003561)	1.59921456
94	Methylmalonic aciduria (HP:0012120)	1.59614654
95	Protruding tongue (HP:0010808)	1.58708635
96	Type 2 muscle fiber atrophy (HP:0003554)	1.57557690
97	Osteomalacia (HP:0002749)	1.57511506
98	Potter facies (HP:0002009)	1.57239688
99	Facial shape deformation (HP:0011334)	1.57239688
100	Hemiplegia (HP:0002301)	1.57050616

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	4.96945781
2	STK38L	4.19370320
3	LATS2	4.16408853
4	BUB1	4.01584433
5	FRK	3.73226917
6	TLK1	3.54579372
7	PINK1	3.48544698
8	NTRK3	2.13837427
9	ZAK	1.93118445
10	MAPKAPK5	1.79570642
11	STK38	1.76905141
12	PAK3	1.69189919
13	PRKD3	1.53469626
14	CASK	1.53316974
15	GRK5	1.45588252
16	CSNK1G2	1.42981980
17	PLK2	1.42004152
18	MARK1	1.41641036
19	CAMK2B	1.41063119
20	DAPK2	1.39903899
21	PRKCG	1.37517200
22	DMPK	1.36684298
23	BMPR1B	1.35420105
24	STK39	1.33273832
25	CSNK1G3	1.31216008
26	CAMK2A	1.29989349
27	PHKG1	1.29718919
28	PHKG2	1.29718919
29	STK16	1.23981884
30	ACVR1B	1.22992272
31	MAP3K12	1.20914670
32	MAPK13	1.19135910
33	EPHA4	1.18343374
34	MAP3K4	1.17680307
35	PAK6	1.12431181
36	ADRBK2	1.08487435
37	CSNK1A1L	1.08223571
38	MINK1	1.00464704
39	MAP2K4	0.98179223
40	MAP2K7	0.97394529
41	CSNK1G1	0.97361163
42	TAOK3	0.96152601
43	PNCK	0.94611057
44	OXSR1	0.91503665
45	GRK1	0.91280341
46	PTK2B	0.91172962
47	STK3	0.89069825
48	CDC7	0.87720277
49	CAMK2G	0.84898409
50	WNK4	0.84476018
51	CAMK2D	0.84321640
52	UHMK1	0.79776725
53	CDK5	0.79666933
54	CAMK1	0.78798880
55	CAMKK2	0.75643746
56	NTRK2	0.73096517
57	NLK	0.71680685
58	MAPKAPK3	0.68937744
59	PIK3CA	0.68927025
60	MAP3K2	0.67362028
61	TNIK	0.66500736
62	MAP2K2	0.58019483
63	CSNK1A1	0.57987243
64	CCNB1	0.57405227
65	SGK2	0.57297983
66	SGK1	0.57288722
67	CSNK1D	0.57228318
68	SGK223	0.57016283
69	SGK494	0.57016283
70	WNK3	0.54793951
71	MELK	0.53995503
72	MAP4K2	0.52625823
73	CDK14	0.52066178
74	PRKD1	0.51789524
75	INSRR	0.50189135
76	CDK15	0.49623212
77	BCKDK	0.48890766
78	ADRBK1	0.48630745
79	RIPK4	0.48405501
80	PRKAA2	0.47197568
81	PRKCE	0.46689105
82	DAPK1	0.46673283
83	CDK18	0.46659321
84	PRKACA	0.45960061
85	CDK11A	0.45859343
86	CDK3	0.45506106
87	PRKCI	0.44726669
88	CSNK1E	0.44221437
89	PRKCZ	0.44088947
90	PRKACB	0.41920366
91	RPS6KA3	0.40739445
92	STK11	0.38690198
93	TEC	0.36721672
94	BMPR2	0.36358330
95	NUAK1	0.35583702
96	PRKG1	0.34304069
97	PKN1	0.33103551
98	MAP2K1	0.30398498
99	TAF1	0.29653228
100	GRK7	0.29082382

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	5.13401913
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.58655194
3	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.86729925
4	Morphine addiction_Homo sapiens_hsa05032	2.79801776
5	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.71013521
6	Phototransduction_Homo sapiens_hsa04744	2.58916556
7	GABAergic synapse_Homo sapiens_hsa04727	2.49276459
8	Collecting duct acid secretion_Homo sapiens_hsa04966	2.49066978
9	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.36401491
10	Amphetamine addiction_Homo sapiens_hsa05031	2.32963340
11	Cocaine addiction_Homo sapiens_hsa05030	2.11047417
12	Taste transduction_Homo sapiens_hsa04742	2.07614997
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.07339616
14	Insulin secretion_Homo sapiens_hsa04911	2.06994414
15	Circadian entrainment_Homo sapiens_hsa04713	2.02471837
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.96936786
17	Dopaminergic synapse_Homo sapiens_hsa04728	1.92760396
18	Glutamatergic synapse_Homo sapiens_hsa04724	1.85394070
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.83210537
20	Salivary secretion_Homo sapiens_hsa04970	1.74094310
21	Parkinsons disease_Homo sapiens_hsa05012	1.67969331
22	Calcium signaling pathway_Homo sapiens_hsa04020	1.66886874
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.63057733
24	Long-term potentiation_Homo sapiens_hsa04720	1.61862275
25	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.57547997
26	Folate biosynthesis_Homo sapiens_hsa00790	1.47698689
27	Serotonergic synapse_Homo sapiens_hsa04726	1.46069834
28	Renin secretion_Homo sapiens_hsa04924	1.33412261
29	Sphingolipid metabolism_Homo sapiens_hsa00600	1.33258858
30	Gastric acid secretion_Homo sapiens_hsa04971	1.32819329
31	Cholinergic synapse_Homo sapiens_hsa04725	1.24401993
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.23358252
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.23198972
34	Alzheimers disease_Homo sapiens_hsa05010	1.18260913
35	Olfactory transduction_Homo sapiens_hsa04740	1.13020049
36	cAMP signaling pathway_Homo sapiens_hsa04024	1.12817549
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.12283175
38	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.09276261
39	Butanoate metabolism_Homo sapiens_hsa00650	1.00036697
40	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.99229288
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.97897620
42	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.96539407
43	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.93215162
44	Selenocompound metabolism_Homo sapiens_hsa00450	0.92502753
45	Long-term depression_Homo sapiens_hsa04730	0.86367569
46	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.85631868
47	Huntingtons disease_Homo sapiens_hsa05016	0.85097134
48	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.85054043
49	Pancreatic secretion_Homo sapiens_hsa04972	0.79710626
50	RNA polymerase_Homo sapiens_hsa03020	0.77868822
51	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.76230746
52	Sulfur relay system_Homo sapiens_hsa04122	0.74889624
53	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.73391342
54	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.72887725
55	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.72554831
56	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70917005
57	Oocyte meiosis_Homo sapiens_hsa04114	0.69288321
58	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.68025738
59	Alcoholism_Homo sapiens_hsa05034	0.68023211
60	Phenylalanine metabolism_Homo sapiens_hsa00360	0.67671706
61	Homologous recombination_Homo sapiens_hsa03440	0.66841997
62	One carbon pool by folate_Homo sapiens_hsa00670	0.66585806
63	Nitrogen metabolism_Homo sapiens_hsa00910	0.63845022
64	Histidine metabolism_Homo sapiens_hsa00340	0.62673037
65	Tyrosine metabolism_Homo sapiens_hsa00350	0.61564932
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60348948
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.56607293
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.54264966
69	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.53109359
70	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.52786430
71	Mineral absorption_Homo sapiens_hsa04978	0.51770210
72	Gap junction_Homo sapiens_hsa04540	0.51730484
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50130546
74	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.49249757
75	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.48260266
76	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.47744449
77	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.45433600
78	Linoleic acid metabolism_Homo sapiens_hsa00591	0.43247047
79	Circadian rhythm_Homo sapiens_hsa04710	0.42362654
80	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.40702116
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38428137
82	Regulation of autophagy_Homo sapiens_hsa04140	0.37492970
83	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.36226966
84	ABC transporters_Homo sapiens_hsa02010	0.36010285
85	African trypanosomiasis_Homo sapiens_hsa05143	0.35657407
86	Peroxisome_Homo sapiens_hsa04146	0.33323422
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33114763
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.32332575
89	Purine metabolism_Homo sapiens_hsa00230	0.31660676
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30392400
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.30308960
92	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.29144024
93	Estrogen signaling pathway_Homo sapiens_hsa04915	0.28156494
94	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.27965470
95	GnRH signaling pathway_Homo sapiens_hsa04912	0.27869581
96	Type II diabetes mellitus_Homo sapiens_hsa04930	0.27555847
97	Protein export_Homo sapiens_hsa03060	0.27001934
98	Metabolic pathways_Homo sapiens_hsa01100	0.26899263
99	Vibrio cholerae infection_Homo sapiens_hsa05110	0.25418739
100	Melanogenesis_Homo sapiens_hsa04916	0.23635394

C5ORF63

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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