ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle maturation (GO:0016188)	4.34162658
2	protein maturation by protein folding (GO:0022417)	4.05928995
3	synaptic vesicle exocytosis (GO:0016079)	4.00971812
4	response to gravity (GO:0009629)	3.86564516
5	ATP hydrolysis coupled proton transport (GO:0015991)	3.79215950
6	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.79215950
7	positive regulation of TOR signaling (GO:0032008)	3.71099870
8	glutamate secretion (GO:0014047)	3.69504427
9	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.66875167
10	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.52154429
11	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.48262668
12	regulation of synapse structural plasticity (GO:0051823)	3.40210005
13	positive regulation of actin filament depolymerization (GO:0030836)	3.33756247
14	GDP-mannose metabolic process (GO:0019673)	3.27213416
15	transferrin transport (GO:0033572)	3.26297851
16	phagosome maturation (GO:0090382)	3.25489747
17	protein complex biogenesis (GO:0070271)	3.23724190
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.10422778
19	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.08474743
20	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.02862437
21	trivalent inorganic cation transport (GO:0072512)	3.02207768
22	ferric iron transport (GO:0015682)	3.02207768
23	platelet dense granule organization (GO:0060155)	2.97923546
24	regulation of autophagic vacuole assembly (GO:2000785)	2.93612895
25	amino sugar catabolic process (GO:0046348)	2.90815430
26	glucosamine-containing compound catabolic process (GO:1901072)	2.89825656
27	positive regulation of neurotransmitter secretion (GO:0001956)	2.86540405
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.82418001
29	NADH dehydrogenase complex assembly (GO:0010257)	2.82418001
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.82418001
31	positive regulation of neurotransmitter transport (GO:0051590)	2.73473289
32	positive regulation of mitochondrial fission (GO:0090141)	2.72966441
33	mannosylation (GO:0097502)	2.72772428
34	negative regulation of cation channel activity (GO:2001258)	2.71496326
35	C-terminal protein lipidation (GO:0006501)	2.69910463
36	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.69453509
37	regulation of synaptic vesicle exocytosis (GO:2000300)	2.67625810
38	mitochondrial respiratory chain complex assembly (GO:0033108)	2.67111419
39	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.67070019
40	neurotransmitter secretion (GO:0007269)	2.65696574
41	respiratory electron transport chain (GO:0022904)	2.65004014
42	regulation of vacuole organization (GO:0044088)	2.63547121
43	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.62799124
44	electron transport chain (GO:0022900)	2.62730433
45	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.61596240
46	inositol phosphate catabolic process (GO:0071545)	2.61525589
47	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.61446481
48	melanin biosynthetic process (GO:0042438)	2.60387533
49	metallo-sulfur cluster assembly (GO:0031163)	2.59976523
50	iron-sulfur cluster assembly (GO:0016226)	2.59976523
51	protein insertion into membrane (GO:0051205)	2.59594424
52	actin nucleation (GO:0045010)	2.57491118
53	inositol phosphate dephosphorylation (GO:0046855)	2.52844678
54	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.52844678
55	negative regulation of glycoprotein metabolic process (GO:1903019)	2.49798997
56	cytochrome complex assembly (GO:0017004)	2.41373463
57	mitotic nuclear envelope reassembly (GO:0007084)	2.41338665
58	nuclear envelope reassembly (GO:0031468)	2.41338665
59	regulation of protein kinase A signaling (GO:0010738)	2.40576908
60	sequestering of actin monomers (GO:0042989)	2.39906503
61	adenosine receptor signaling pathway (GO:0001973)	2.37688830
62	type B pancreatic cell proliferation (GO:0044342)	2.36751523
63	respiratory chain complex IV assembly (GO:0008535)	2.35708615
64	regulation of synaptic vesicle transport (GO:1902803)	2.33733624
65	hydrogen ion transmembrane transport (GO:1902600)	2.32790811
66	synaptic transmission, glutamatergic (GO:0035249)	2.31756770
67	glycosphingolipid biosynthetic process (GO:0006688)	2.31482028
68	mitochondrial calcium ion homeostasis (GO:0051560)	2.31225202
69	extracellular fibril organization (GO:0043206)	2.29961675
70	regulation of amyloid precursor protein catabolic process (GO:1902991)	2.29894142
71	cellular response to zinc ion (GO:0071294)	2.29139960
72	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	2.26109964
73	negative regulation of calcium ion transmembrane transport (GO:1903170)	2.26109964
74	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.25423545
75	pyrimidine nucleoside salvage (GO:0043097)	2.25215505
76	pyrimidine-containing compound salvage (GO:0008655)	2.25215505
77	C-terminal protein amino acid modification (GO:0018410)	2.23525523
78	cellular potassium ion homeostasis (GO:0030007)	2.23187240
79	endoplasmic reticulum calcium ion homeostasis (GO:0032469)	2.20236980
80	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	2.19785530
81	gamma-aminobutyric acid transport (GO:0015812)	2.18918604
82	fibril organization (GO:0097435)	2.18852562
83	proton transport (GO:0015992)	2.18348912
84	DNA deamination (GO:0045006)	2.17464746
85	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.16365187
86	hydrogen transport (GO:0006818)	2.16063478
87	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.15757516
88	deoxyribose phosphate biosynthetic process (GO:0046385)	2.15757516
89	GPI anchor biosynthetic process (GO:0006506)	2.15747466
90	viral protein processing (GO:0019082)	2.14190883
91	virion assembly (GO:0019068)	2.10977805
92	endosome to melanosome transport (GO:0035646)	2.10959059
93	endosome to pigment granule transport (GO:0043485)	2.10959059
94	ATP synthesis coupled proton transport (GO:0015986)	2.10742460
95	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.10742460
96	response to interferon-beta (GO:0035456)	2.10308409
97	melanin metabolic process (GO:0006582)	2.09120126
98	glycolipid biosynthetic process (GO:0009247)	2.07873294
99	adaptation of signaling pathway (GO:0023058)	2.07509602
100	synaptic vesicle endocytosis (GO:0048488)	2.06204017

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.90189946
2	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.80711399
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.73695082
4	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.32594888
5	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.26506540
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.25817184
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.25602625
8	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.21383275
9	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.15714569
10	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.05522433
11	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.04801375
12	* BCL6_27268052_Chip-Seq_Bcells_Human	2.02000667
13	LXR_22292898_ChIP-Seq_THP-1_Human	1.97429265
14	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.97071809
15	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.95075032
16	* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.91328900
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.90274966
18	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.89650589
19	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.88710382
20	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.87368149
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.87249705
22	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.81184632
23	P68_20966046_ChIP-Seq_HELA_Human	1.79967010
24	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.75467173
25	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.69716043
26	* BCOR_27268052_Chip-Seq_Bcells_Human	1.68225872
27	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.65665603
28	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.63827727
29	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.57370290
30	CTCF_20526341_ChIP-Seq_ESCs_Human	1.52701097
31	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.52541517
32	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.51714750
33	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.51629339
34	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.50893348
35	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.50702214
36	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.49208598
37	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.48422123
38	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.48360630
39	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.46239992
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.43243220
41	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.43144925
42	E2F1_20622854_ChIP-Seq_HELA_Human	1.40133112
43	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.40048001
44	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.39761246
45	* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.39749421
46	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.38374018
47	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.37705102
48	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.36820008
49	* CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.35285893
50	PHF8_20622854_ChIP-Seq_HELA_Human	1.34068345
51	TFEB_21752829_ChIP-Seq_HELA_Human	1.33951203
52	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.33174520
53	* ELK3_25401928_ChIP-Seq_HUVEC_Human	1.30428080
54	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.29316784
55	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.27672191
56	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.26192553
57	GABP_19822575_ChIP-Seq_HepG2_Human	1.24829896
58	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.24697481
59	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.23767569
60	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.23146231
61	* SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.22815568
62	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.21657046
63	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.21194954
64	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.18669121
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.18378581
66	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.17367054
67	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.16273142
68	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.15530127
69	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.15056138
70	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.14655377
71	* VDR_21846776_ChIP-Seq_THP-1_Human	1.13043031
72	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.11948316
73	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.11621724
74	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.11194203
75	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.11057382
76	SA1_27219007_Chip-Seq_Bcells_Human	1.10661961
77	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.10000360
78	* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.09412947
79	MAF_26560356_Chip-Seq_TH2_Human	1.09206304
80	SPI1_20517297_ChIP-Seq_HL60_Human	1.07520146
81	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.06240696
82	* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.06063400
83	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.05376172
84	P300_27268052_Chip-Seq_Bcells_Human	1.04975942
85	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.04576548
86	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.04267691
87	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.03590279
88	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.03544958
89	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.02576326
90	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99336821
91	DCP1A_22483619_ChIP-Seq_HELA_Human	0.98239735
92	VDR_23849224_ChIP-Seq_CD4+_Human	0.97966325
93	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.97715961
94	* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.97650462
95	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.97013697
96	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.96267023
97	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.96190517
98	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.96099630
99	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.94861188
100	STAT1_20625510_ChIP-Seq_HELA_Human	0.94743553

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	3.39747711
2	MP0005423_abnormal_somatic_nervous	2.85492367
3	MP0003880_abnormal_central_pattern	2.79543536
4	MP0005058_abnormal_lysosome_morphology	2.60724008
5	MP0005171_absent_coat_pigmentation	2.58230831
6	MP0001968_abnormal_touch/_nociception	2.45044049
7	MP0009046_muscle_twitch	2.44524293
8	MP0001905_abnormal_dopamine_level	2.28034358
9	MP0002064_seizures	2.24817956
10	MP0004270_analgesia	2.19868762
11	MP0003172_abnormal_lysosome_physiology	2.16967525
12	MP0003635_abnormal_synaptic_transmissio	2.12964443
13	MP0009745_abnormal_behavioral_response	2.06328571
14	MP0002272_abnormal_nervous_system	1.97424366
15	MP0002736_abnormal_nociception_after	1.96532605
16	MP0009840_abnormal_foam_cell	1.92876364
17	MP0003075_altered_response_to	1.75678597
18	MP0003806_abnormal_nucleotide_metabolis	1.75664850
19	MP0003329_amyloid_beta_deposits	1.73730307
20	MP0001970_abnormal_pain_threshold	1.73557610
21	MP0002063_abnormal_learning/memory/cond	1.71147078
22	MP0004510_myositis	1.70294717
23	MP0001502_abnormal_circadian_rhythm	1.69620630
24	MP0001986_abnormal_taste_sensitivity	1.66930435
25	MP0002572_abnormal_emotion/affect_behav	1.64938166
26	MP0000015_abnormal_ear_pigmentation	1.63355037
27	MP0000343_altered_response_to	1.61022382
28	MP0000372_irregular_coat_pigmentation	1.58739276
29	MP0005174_abnormal_tail_pigmentation	1.57062962
30	MP0006082_CNS_inflammation	1.55147340
31	MP0001542_abnormal_bone_strength	1.51930573
32	MP0002909_abnormal_adrenal_gland	1.50453549
33	MP0001486_abnormal_startle_reflex	1.40538646
34	MP0002837_dystrophic_cardiac_calcinosis	1.40100624
35	MP0002734_abnormal_mechanical_nocicepti	1.37992474
36	MP0002733_abnormal_thermal_nociception	1.37450387
37	MP0001501_abnormal_sleep_pattern	1.37330722
38	MP0003191_abnormal_cellular_cholesterol	1.37187414
39	MP0003879_abnormal_hair_cell	1.36588497
40	MP0002735_abnormal_chemical_nociception	1.30115657
41	MP0002822_catalepsy	1.29738544
42	MP0003123_paternal_imprinting	1.27595413
43	MP0006036_abnormal_mitochondrial_physio	1.27354506
44	MP0002148_abnormal_hypersensitivity_rea	1.26457023
45	MP0003011_delayed_dark_adaptation	1.24684361
46	MP0000750_abnormal_muscle_regeneration	1.24414667
47	MP0000604_amyloidosis	1.23979172
48	MP0002332_abnormal_exercise_endurance	1.23347202
49	MP0000920_abnormal_myelination	1.22774769
50	MP0003136_yellow_coat_color	1.21413033
51	MP0003633_abnormal_nervous_system	1.20223501
52	MP0003436_decreased_susceptibility_to	1.19371052
53	MP0001756_abnormal_urination	1.17450108
54	MP0005551_abnormal_eye_electrophysiolog	1.16813831
55	MP0006276_abnormal_autonomic_nervous	1.16610939
56	MP0002067_abnormal_sensory_capabilities	1.14336873
57	MP0002638_abnormal_pupillary_reflex	1.11706369
58	MP0009780_abnormal_chondrocyte_physiolo	1.05848484
59	MP0002229_neurodegeneration	1.04552230
60	MP0002557_abnormal_social/conspecific_i	1.04444913
61	MP0005671_abnormal_response_to	1.04069184
62	MP0010386_abnormal_urinary_bladder	1.04031482
63	MP0008569_lethality_at_weaning	1.03048306
64	MP0005535_abnormal_body_temperature	1.01809559
65	MP0003195_calcinosis	1.01043700
66	MP0008874_decreased_physiological_sensi	0.98530337
67	MP0008260_abnormal_autophagy	0.98392325
68	MP0005464_abnormal_platelet_physiology	0.98293646
69	MP0005084_abnormal_gallbladder_morpholo	0.94780613
70	MP0005166_decreased_susceptibility_to	0.94104234
71	MP0005386_behavior/neurological_phenoty	0.93291759
72	MP0004924_abnormal_behavior	0.93291759
73	MP0003690_abnormal_glial_cell	0.92905614
74	MP0009785_altered_susceptibility_to	0.92398853
75	MP0004142_abnormal_muscle_tone	0.91645100
76	MP0003724_increased_susceptibility_to	0.91247309
77	MP0002090_abnormal_vision	0.90701781
78	MP0005000_abnormal_immune_tolerance	0.89728241
79	MP0001984_abnormal_olfaction	0.89028278
80	MP0003631_nervous_system_phenotype	0.88228325
81	MP0005584_abnormal_enzyme/coenzyme_acti	0.87883656
82	MP0005253_abnormal_eye_physiology	0.87041253
83	MP0002066_abnormal_motor_capabilities/c	0.86909009
84	MP0004885_abnormal_endolymph	0.86789846
85	MP0005646_abnormal_pituitary_gland	0.84825524
86	MP0004811_abnormal_neuron_physiology	0.84036596
87	MP0009764_decreased_sensitivity_to	0.82229165
88	MP0005025_abnormal_response_to	0.81333408
89	MP0002095_abnormal_skin_pigmentation	0.80876325
90	MP0001529_abnormal_vocalization	0.79886030
91	MP0000639_abnormal_adrenal_gland	0.78762645
92	MP0005379_endocrine/exocrine_gland_phen	0.78113912
93	MP0005332_abnormal_amino_acid	0.77523479
94	MP0006035_abnormal_mitochondrial_morpho	0.77320688
95	MP0005165_increased_susceptibility_to	0.76968214
96	MP0008875_abnormal_xenobiotic_pharmacok	0.76021640
97	MP0002419_abnormal_innate_immunity	0.75958244
98	MP0002693_abnormal_pancreas_physiology	0.75801832
99	MP0005167_abnormal_blood-brain_barrier	0.74793757
100	MP0005083_abnormal_biliary_tract	0.74309350

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glycolipid metabolism (HP:0010969)	3.90192938
2	Abnormality of liposaccharide metabolism (HP:0010968)	3.90192938
3	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.90192938
4	Mitochondrial inheritance (HP:0001427)	3.59479568
5	Hepatocellular necrosis (HP:0001404)	3.49491693
6	Supranuclear gaze palsy (HP:0000605)	3.48119262
7	Acute necrotizing encephalopathy (HP:0006965)	3.29434195
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.18304227
9	Hepatic necrosis (HP:0002605)	3.17461606
10	Progressive macrocephaly (HP:0004481)	3.01787857
11	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.98650751
12	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.98650751
13	Myokymia (HP:0002411)	2.94814276
14	Dysostosis multiplex (HP:0000943)	2.94185924
15	Increased CSF lactate (HP:0002490)	2.87135103
16	Renal Fanconi syndrome (HP:0001994)	2.86182127
17	Delusions (HP:0000746)	2.71611640
18	Polyphagia (HP:0002591)	2.71443259
19	Progressive neurologic deterioration (HP:0002344)	2.70685140
20	Mutism (HP:0002300)	2.67649698
21	Retinal dysplasia (HP:0007973)	2.64077251
22	Abnormality of polysaccharide metabolism (HP:0011012)	2.62252173
23	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.62252173
24	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.62252173
25	Hand muscle atrophy (HP:0009130)	2.61348444
26	Hypokinesia (HP:0002375)	2.60034542
27	Acute encephalopathy (HP:0006846)	2.57928376
28	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.54317551
29	Increased intramyocellular lipid droplets (HP:0012240)	2.54110596
30	Increased hepatocellular lipid droplets (HP:0006565)	2.52656280
31	Cerebral hypomyelination (HP:0006808)	2.45438761
32	Abnormality of binocular vision (HP:0011514)	2.45398998
33	Diplopia (HP:0000651)	2.45398998
34	Upper limb muscle weakness (HP:0003484)	2.45203804
35	Vacuolated lymphocytes (HP:0001922)	2.45022066
36	Prolonged neonatal jaundice (HP:0006579)	2.40455312
37	Mucopolysacchariduria (HP:0008155)	2.33702547
38	Urinary glycosaminoglycan excretion (HP:0003541)	2.33702547
39	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.33102306
40	Retinal atrophy (HP:0001105)	2.31065884
41	Emotional lability (HP:0000712)	2.30549462
42	Neurofibrillary tangles (HP:0002185)	2.29114131
43	Tongue fasciculations (HP:0001308)	2.28642218
44	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.27198349
45	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.26378039
46	Lipid accumulation in hepatocytes (HP:0006561)	2.24378143
47	Loss of speech (HP:0002371)	2.23506941
48	Testicular atrophy (HP:0000029)	2.22839152
49	Neuronal loss in central nervous system (HP:0002529)	2.22461479
50	Hemiparesis (HP:0001269)	2.21805581
51	Increased muscle lipid content (HP:0009058)	2.21354057
52	Axonal loss (HP:0003447)	2.20217722
53	Exertional dyspnea (HP:0002875)	2.20208365
54	Abnormal gallbladder physiology (HP:0012438)	2.16988067
55	Cholecystitis (HP:0001082)	2.16988067
56	Action tremor (HP:0002345)	2.14804697
57	Upper limb amyotrophy (HP:0009129)	2.13759873
58	Distal upper limb amyotrophy (HP:0007149)	2.13759873
59	Ketoacidosis (HP:0001993)	2.12210010
60	Progressive microcephaly (HP:0000253)	2.10075195
61	Lactic acidosis (HP:0003128)	2.09352339
62	Petechiae (HP:0000967)	2.08308789
63	Respiratory failure (HP:0002878)	2.07967086
64	Diminished movement (HP:0002374)	2.06945189
65	Absent speech (HP:0001344)	2.06884370
66	Visual hallucinations (HP:0002367)	2.06767391
67	Akinesia (HP:0002304)	2.06497532
68	Abnormal eating behavior (HP:0100738)	2.04126061
69	Opisthotonus (HP:0002179)	2.02525962
70	Intention tremor (HP:0002080)	2.02004227
71	Amyloidosis (HP:0011034)	2.01977511
72	Exercise intolerance (HP:0003546)	2.01782194
73	Muscle fibrillation (HP:0010546)	2.01659930
74	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.01348739
75	Ocular albinism (HP:0001107)	2.00043409
76	Severe muscular hypotonia (HP:0006829)	1.95203067
77	Congenital stationary night blindness (HP:0007642)	1.93048293
78	Elevated erythrocyte sedimentation rate (HP:0003565)	1.92790569
79	Focal dystonia (HP:0004373)	1.92128308
80	Abnormality of macrophages (HP:0004311)	1.92018177
81	Albinism (HP:0001022)	1.91682822
82	Type I transferrin isoform profile (HP:0003642)	1.91209783
83	Focal motor seizures (HP:0011153)	1.89160455
84	Diminished motivation (HP:0000745)	1.88379198
85	Increased cerebral lipofuscin (HP:0011813)	1.87540288
86	Dysautonomia (HP:0002459)	1.87010409
87	Myoclonus (HP:0001336)	1.86680761
88	Epileptiform EEG discharges (HP:0011182)	1.85706183
89	Hyperthyroidism (HP:0000836)	1.83493991
90	EEG with generalized epileptiform discharges (HP:0011198)	1.83438566
91	Epileptic encephalopathy (HP:0200134)	1.82397205
92	Agitation (HP:0000713)	1.81868813
93	Ankle clonus (HP:0011448)	1.81794551
94	Tetraplegia (HP:0002445)	1.81755185
95	Nuclear cataract (HP:0100018)	1.81068278
96	Increased serum lactate (HP:0002151)	1.80263097
97	Adrenal hypoplasia (HP:0000835)	1.80004078
98	Apathy (HP:0000741)	1.79744461
99	Iris hypopigmentation (HP:0007730)	1.78675256
100	3-Methylglutaconic aciduria (HP:0003535)	1.77352068

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK1	4.19121595
2	TESK2	3.74336860
3	LIMK1	3.63657027
4	DAPK2	2.46253308
5	ARAF	2.43382194
6	PAK6	2.21497956
7	PIM2	2.14099069
8	NME2	2.06782848
9	DAPK1	1.97294090
10	MAP3K11	1.95252443
11	GRK5	1.94663861
12	MAP3K12	1.67354451
13	MAP2K7	1.66684449
14	BCKDK	1.65350250
15	LMTK2	1.62082371
16	CSNK1G3	1.61208826
17	SIK3	1.58287677
18	PHKG1	1.53628460
19	PHKG2	1.53628460
20	VRK2	1.52242687
21	PRKD3	1.50199029
22	STK16	1.49437819
23	CSNK1G2	1.46354992
24	TAOK2	1.38158082
25	TBK1	1.37504968
26	GRK7	1.35312468
27	CSNK1A1L	1.31717725
28	EPHA4	1.29090671
29	MARK1	1.28214967
30	ABL2	1.23504639
31	MAP4K2	1.21118925
32	PINK1	1.17247080
33	MAPKAPK3	1.16378803
34	SIK2	1.15346288
35	NTRK3	1.11190062
36	MINK1	1.07054137
37	PTK2B	1.05982222
38	DAPK3	1.04864381
39	IRAK3	1.04706251
40	ERN1	1.04406501
41	PRKD2	1.03390692
42	PLK2	0.98596853
43	PAK3	0.93108642
44	EPHB1	0.92792509
45	KDR	0.91652591
46	CSNK1G1	0.91345413
47	FRK	0.89995840
48	MAPK13	0.89627539
49	ADRBK2	0.89457237
50	MAP2K6	0.87815973
51	CAMKK2	0.87309717
52	MAP3K4	0.85072242
53	MOS	0.81504808
54	TRIM28	0.79611823
55	BLK	0.78766117
56	MAP3K3	0.78500531
57	CDK14	0.77079637
58	GRK6	0.75753550
59	PKN1	0.74346055
60	TNK2	0.74273798
61	RIPK4	0.70987961
62	HIPK2	0.70620268
63	TXK	0.69719725
64	IKBKB	0.69389681
65	PAK1	0.69157155
66	CAMK2G	0.68106681
67	CCNB1	0.68009368
68	PRKCG	0.66615014
69	ADRBK1	0.65685702
70	CDK18	0.63879160
71	UHMK1	0.63388700
72	IKBKE	0.62918488
73	IRAK2	0.62713504
74	PRKCI	0.62677901
75	CAMK2D	0.62607675
76	CDK5	0.60907620
77	CAMKK1	0.60813950
78	CDK15	0.60536662
79	TLK1	0.60505899
80	ZAP70	0.60442929
81	MYLK	0.60055517
82	PRKD1	0.58785430
83	CDK11A	0.58269275
84	STK38	0.57224813
85	EPHA3	0.56360163
86	GRK1	0.55710754
87	AURKA	0.55029812
88	BRAF	0.53889818
89	BMPR2	0.53742628
90	MAP4K1	0.53531110
91	CAMK2A	0.51365682
92	TAOK1	0.50865720
93	FER	0.50741471
94	CDK19	0.49467406
95	CAMK2B	0.45224924
96	MAP3K1	0.43620970
97	ILK	0.42829639
98	MARK3	0.42506890
99	TAOK3	0.41105954
100	MAPK12	0.37607462

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.88645346
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.81695821
3	Collecting duct acid secretion_Homo sapiens_hsa04966	3.41168086
4	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.40180540
5	Parkinsons disease_Homo sapiens_hsa05012	2.70213134
6	Vibrio cholerae infection_Homo sapiens_hsa05110	2.61196280
7	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.55735145
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.36909961
9	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.26503113
10	Sulfur relay system_Homo sapiens_hsa04122	2.24427930
11	Alzheimers disease_Homo sapiens_hsa05010	2.22207745
12	Lysosome_Homo sapiens_hsa04142	2.15042771
13	Other glycan degradation_Homo sapiens_hsa00511	1.99327928
14	Nicotine addiction_Homo sapiens_hsa05033	1.85893963
15	Fatty acid elongation_Homo sapiens_hsa00062	1.79122993
16	Folate biosynthesis_Homo sapiens_hsa00790	1.73404975
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.68785983
18	Proteasome_Homo sapiens_hsa03050	1.67531709
19	Huntingtons disease_Homo sapiens_hsa05016	1.61509993
20	Rheumatoid arthritis_Homo sapiens_hsa05323	1.60194800
21	GABAergic synapse_Homo sapiens_hsa04727	1.53927238
22	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.53480359
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.50074810
24	Insulin secretion_Homo sapiens_hsa04911	1.49827972
25	Morphine addiction_Homo sapiens_hsa05032	1.42210030
26	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.36496311
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.35742587
28	Salivary secretion_Homo sapiens_hsa04970	1.34733404
29	Regulation of autophagy_Homo sapiens_hsa04140	1.26404991
30	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.23327810
31	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.23289585
32	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.22287493
33	Amphetamine addiction_Homo sapiens_hsa05031	1.20903110
34	Phagosome_Homo sapiens_hsa04145	1.20484748
35	Protein export_Homo sapiens_hsa03060	1.19492763
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.17850773
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.16255796
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.15552750
39	Circadian entrainment_Homo sapiens_hsa04713	1.14236892
40	Dopaminergic synapse_Homo sapiens_hsa04728	1.12804791
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.06762163
42	Cocaine addiction_Homo sapiens_hsa05030	1.06598686
43	Endocytosis_Homo sapiens_hsa04144	1.03782214
44	Sulfur metabolism_Homo sapiens_hsa00920	1.00460674
45	Type I diabetes mellitus_Homo sapiens_hsa04940	1.00265704
46	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.94092343
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92791924
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.91697460
49	RNA polymerase_Homo sapiens_hsa03020	0.90889934
50	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.86194134
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83291924
52	Salmonella infection_Homo sapiens_hsa05132	0.82610333
53	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.80391946
54	Shigellosis_Homo sapiens_hsa05131	0.79936177
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.76406409
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76034235
57	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.72545260
58	Sphingolipid metabolism_Homo sapiens_hsa00600	0.71212943
59	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.70394944
60	Galactose metabolism_Homo sapiens_hsa00052	0.68048078
61	Phototransduction_Homo sapiens_hsa04744	0.67298064
62	Glutathione metabolism_Homo sapiens_hsa00480	0.66386558
63	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.65799506
64	Gastric acid secretion_Homo sapiens_hsa04971	0.65454990
65	Tuberculosis_Homo sapiens_hsa05152	0.61725083
66	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.56315426
67	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54947050
68	Long-term potentiation_Homo sapiens_hsa04720	0.52132945
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.51522731
70	Peroxisome_Homo sapiens_hsa04146	0.48440763
71	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.47666392
72	Pertussis_Homo sapiens_hsa05133	0.47659266
73	Metabolic pathways_Homo sapiens_hsa01100	0.47540435
74	Pyrimidine metabolism_Homo sapiens_hsa00240	0.45045901
75	Serotonergic synapse_Homo sapiens_hsa04726	0.43202232
76	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.38112518
77	Cholinergic synapse_Homo sapiens_hsa04725	0.37578932
78	Mineral absorption_Homo sapiens_hsa04978	0.36635407
79	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.36335690
80	Taste transduction_Homo sapiens_hsa04742	0.34939094
81	Graft-versus-host disease_Homo sapiens_hsa05332	0.32405703
82	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.31782923
83	Pentose phosphate pathway_Homo sapiens_hsa00030	0.31247599
84	Renin secretion_Homo sapiens_hsa04924	0.31064742
85	Long-term depression_Homo sapiens_hsa04730	0.30885079
86	Ether lipid metabolism_Homo sapiens_hsa00565	0.30846304
87	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.30153606
88	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.29695819
89	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.29432738
90	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.29162289
91	Butanoate metabolism_Homo sapiens_hsa00650	0.28847099
92	Osteoclast differentiation_Homo sapiens_hsa04380	0.27521608
93	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.27161644
94	Alcoholism_Homo sapiens_hsa05034	0.27093576
95	Allograft rejection_Homo sapiens_hsa05330	0.26941320
96	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.26814398
97	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.26783402
98	Primary immunodeficiency_Homo sapiens_hsa05340	0.24933071
99	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.24011196
100	Legionellosis_Homo sapiens_hsa05134	0.23605583

C6ORF1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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