ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	melanin biosynthetic process (GO:0042438)	9.43444854
2	melanin metabolic process (GO:0006582)	8.61184777
3	secondary metabolite biosynthetic process (GO:0044550)	8.06178400
4	microtubule depolymerization (GO:0007019)	6.22496899
5	acrosome reaction (GO:0007340)	6.07490692
6	regulation of meiosis I (GO:0060631)	5.85388304
7	fusion of sperm to egg plasma membrane (GO:0007342)	5.40744097
8	attachment of spindle microtubules to kinetochore (GO:0008608)	5.21545908
9	response to pheromone (GO:0019236)	5.15744680
10	synapsis (GO:0007129)	5.10796990
11	regulation of DNA endoreduplication (GO:0032875)	4.86533393
12	microtubule polymerization or depolymerization (GO:0031109)	4.85739918
13	sperm motility (GO:0030317)	4.81206623
14	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	4.75911989
15	ketone body metabolic process (GO:1902224)	4.52687356
16	developmental pigmentation (GO:0048066)	4.48938292
17	polyol catabolic process (GO:0046174)	4.48245588
18	phenol-containing compound biosynthetic process (GO:0046189)	4.40964940
19	centriole replication (GO:0007099)	4.38710410
20	single strand break repair (GO:0000012)	4.37800122
21	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.37613120
22	inositol phosphate catabolic process (GO:0071545)	4.28426730
23	calcium ion-dependent exocytosis (GO:0017156)	4.26154065
24	plasma membrane fusion (GO:0045026)	4.13671521
25	retinal rod cell development (GO:0046548)	4.09767344
26	sister chromatid cohesion (GO:0007062)	3.99943963
27	piRNA metabolic process (GO:0034587)	3.98887749
28	RNA localization (GO:0006403)	3.95532106
29	intra-S DNA damage checkpoint (GO:0031573)	3.94065089
30	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.89429244
31	auditory receptor cell stereocilium organization (GO:0060088)	3.85153517
32	regulation of cilium movement (GO:0003352)	3.77416605
33	melanosome organization (GO:0032438)	3.69344602
34	microtubule anchoring (GO:0034453)	3.64353570
35	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.58831531
36	pigment granule organization (GO:0048753)	3.50570935
37	chromosome organization involved in meiosis (GO:0070192)	3.43956195
38	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.41038616
39	inositol phosphate dephosphorylation (GO:0046855)	3.41038616
40	negative regulation of meiosis (GO:0045835)	3.40933455
41	reciprocal meiotic recombination (GO:0007131)	3.40774937
42	reciprocal DNA recombination (GO:0035825)	3.40774937
43	chromosome condensation (GO:0030261)	3.37783838
44	sympathetic nervous system development (GO:0048485)	3.36415592
45	DNA packaging (GO:0006323)	3.36146498
46	melanocyte differentiation (GO:0030318)	3.33645416
47	centrosome duplication (GO:0051298)	3.32443490
48	protein localization to kinetochore (GO:0034501)	3.28925273
49	regulation of centriole replication (GO:0046599)	3.28736531
50	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.23036221
51	pigment cell differentiation (GO:0050931)	3.17532849
52	DNA methylation involved in gamete generation (GO:0043046)	3.14752103
53	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.14195044
54	C4-dicarboxylate transport (GO:0015740)	3.12748307
55	seminiferous tubule development (GO:0072520)	3.12468768
56	spermatid development (GO:0007286)	3.07236064
57	male meiosis (GO:0007140)	3.05827295
58	short-term memory (GO:0007614)	3.01022771
59	oogenesis (GO:0048477)	2.99238154
60	histone exchange (GO:0043486)	2.98786408
61	inner ear receptor stereocilium organization (GO:0060122)	2.98274169
62	cell wall macromolecule metabolic process (GO:0044036)	2.97284603
63	centriole assembly (GO:0098534)	2.96862038
64	dopamine transport (GO:0015872)	2.95657311
65	epithelial cilium movement (GO:0003351)	2.94674190
66	postsynaptic membrane organization (GO:0001941)	2.94121456
67	male meiosis I (GO:0007141)	2.93347278
68	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.91741018
69	regulation of pigment cell differentiation (GO:0050932)	2.89337914
70	negative regulation of organelle assembly (GO:1902116)	2.88321056
71	telomere maintenance via telomerase (GO:0007004)	2.87585378
72	mitotic G2 DNA damage checkpoint (GO:0007095)	2.84886643
73	neuroepithelial cell differentiation (GO:0060563)	2.82364541
74	protein polyglutamylation (GO:0018095)	2.81757215
75	negative regulation of neurotransmitter transport (GO:0051589)	2.77332878
76	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.76263321
77	neural tube formation (GO:0001841)	2.75701764
78	positive regulation of protein autophosphorylation (GO:0031954)	2.75392404
79	negative regulation of microtubule polymerization (GO:0031115)	2.74477403
80	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.74055353
81	cell wall macromolecule catabolic process (GO:0016998)	2.72319146
82	microtubule cytoskeleton organization involved in mitosis (GO:1902850)	2.72020954
83	spermatogenesis (GO:0007283)	2.70909821
84	male gamete generation (GO:0048232)	2.70407763
85	protein K11-linked deubiquitination (GO:0035871)	2.69270215
86	microtubule severing (GO:0051013)	2.65459407
87	microtubule nucleation (GO:0007020)	2.65208709
88	mitotic sister chromatid segregation (GO:0000070)	2.64274379
89	meiotic nuclear division (GO:0007126)	2.63636026
90	mitotic G2/M transition checkpoint (GO:0044818)	2.62419495
91	histone mRNA catabolic process (GO:0071044)	2.60628121
92	meiotic cell cycle process (GO:1903046)	2.59153953
93	recombinational repair (GO:0000725)	2.58800818
94	gamete generation (GO:0007276)	2.58001457
95	double-strand break repair via homologous recombination (GO:0000724)	2.57129921
96	regulation of DNA-dependent DNA replication (GO:0090329)	2.56789585
97	negative regulation of meiotic cell cycle (GO:0051447)	2.56409231
98	double-strand break repair via nonhomologous end joining (GO:0006303)	2.55860380
99	non-recombinational repair (GO:0000726)	2.55860380
100	presynaptic membrane assembly (GO:0097105)	2.55000477

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.78379358
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.16853862
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.06477340
4	FUS_26573619_Chip-Seq_HEK293_Human	2.85369785
5	VDR_22108803_ChIP-Seq_LS180_Human	2.75344776
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.56230805
7	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.51674035
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.45806251
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.43927802
10	ER_23166858_ChIP-Seq_MCF-7_Human	2.34238981
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.31386655
12	E2F7_22180533_ChIP-Seq_HELA_Human	2.26376671
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23048452
14	P300_19829295_ChIP-Seq_ESCs_Human	2.17699732
15	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	2.05286846
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.05220193
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.04953524
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01436877
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.96223747
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.94686855
21	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.94469064
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.90129318
23	CBP_20019798_ChIP-Seq_JUKART_Human	1.90129318
24	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.88825153
25	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.86953360
26	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.85242844
27	EZH2_22144423_ChIP-Seq_EOC_Human	1.85005467
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.84441112
29	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.84441112
30	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.83531676
31	AR_25329375_ChIP-Seq_VCAP_Human	1.79653175
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.78449006
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.74293149
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73915231
35	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.71657227
36	EWS_26573619_Chip-Seq_HEK293_Human	1.69326578
37	STAT3_23295773_ChIP-Seq_U87_Human	1.67381520
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.67239157
39	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.64982501
40	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.63404579
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.60453419
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.56670974
43	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.53108511
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.52421332
45	TCF4_23295773_ChIP-Seq_U87_Human	1.52214717
46	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.50911979
47	AR_21572438_ChIP-Seq_LNCaP_Human	1.50767945
48	IGF1R_20145208_ChIP-Seq_DFB_Human	1.49508277
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.48756408
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44998469
51	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44021514
52	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.43599731
53	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43562646
54	RUNX2_22187159_ChIP-Seq_PCA_Human	1.42199730
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37794499
56	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.35918486
57	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.35585161
58	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.35402062
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35232966
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32381786
61	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.29085600
62	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.29027768
63	BCAT_22108803_ChIP-Seq_LS180_Human	1.26085911
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25284356
65	* SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24759103
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.23382572
67	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.20700066
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20495505
69	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.19735583
70	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19490305
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18944667
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18944667
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18479878
74	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.13933835
75	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.13366642
76	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.12901866
77	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.10476004
78	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10141273
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09359016
80	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08922251
81	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.06915537
82	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06865158
83	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.05843921
84	TP53_16413492_ChIP-PET_HCT116_Human	1.05734487
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05615695
86	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.05477037
87	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05380419
88	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05191050
89	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.05180196
90	ETV1_20927104_ChIP-Seq_GIST48_Human	1.04777303
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03390774
92	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.02606970
93	NFYA_21822215_ChIP-Seq_K562_Human	1.01139168
94	NFYB_21822215_ChIP-Seq_K562_Human	1.01123418
95	P300_18555785_Chip-Seq_ESCs_Mouse	1.00362757
96	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.99414504
97	KDM2B_26808549_Chip-Seq_REH_Human	0.99223159
98	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.99108471
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98224460
100	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97871425

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	7.04831085
2	MP0005171_absent_coat_pigmentation	4.47188839
3	MP0005408_hypopigmentation	4.22715751
4	MP0000015_abnormal_ear_pigmentation	4.10345856
5	MP0002102_abnormal_ear_morphology	4.04939573
6	MP0005075_abnormal_melanosome_morpholog	3.75174083
7	MP0003136_yellow_coat_color	3.33895061
8	MP0005410_abnormal_fertilization	2.96036429
9	MP0005377_hearing/vestibular/ear_phenot	2.78106924
10	MP0003878_abnormal_ear_physiology	2.78106924
11	MP0002095_abnormal_skin_pigmentation	2.76423959
12	MP0003950_abnormal_plasma_membrane	2.73571483
13	MP0003646_muscle_fatigue	2.67699807
14	MP0005174_abnormal_tail_pigmentation	2.54769913
15	MP0000371_diluted_coat_color	2.53234786
16	MP0000569_abnormal_digit_pigmentation	2.39124134
17	MP0008058_abnormal_DNA_repair	2.35965297
18	MP0001324_abnormal_eye_pigmentation	2.24813093
19	MP0008057_abnormal_DNA_replication	2.22668834
20	MP0003806_abnormal_nucleotide_metabolis	2.13749742
21	MP0010094_abnormal_chromosome_stability	1.93079918
22	MP0002090_abnormal_vision	1.84598972
23	MP0002938_white_spotting	1.84304160
24	MP0005551_abnormal_eye_electrophysiolog	1.83045520
25	MP0005253_abnormal_eye_physiology	1.82213840
26	MP0003787_abnormal_imprinting	1.81244369
27	MP0004381_abnormal_hair_follicle	1.77573875
28	MP0005257_abnormal_intraocular_pressure	1.76745310
29	MP0005670_abnormal_white_adipose	1.73134034
30	MP0006072_abnormal_retinal_apoptosis	1.65722516
31	MP0008877_abnormal_DNA_methylation	1.65690371
32	MP0002822_catalepsy	1.64707764
33	MP0003718_maternal_effect	1.61390418
34	MP0002736_abnormal_nociception_after	1.51925802
35	MP0006292_abnormal_olfactory_placode	1.43407245
36	MP0003698_abnormal_male_reproductive	1.38322346
37	MP0001501_abnormal_sleep_pattern	1.37586318
38	MP0001188_hyperpigmentation	1.35137964
39	MP0002075_abnormal_coat/hair_pigmentati	1.32261051
40	MP0005386_behavior/neurological_phenoty	1.27098090
41	MP0004924_abnormal_behavior	1.27098090
42	MP0002653_abnormal_ependyma_morphology	1.23160754
43	MP0001929_abnormal_gametogenesis	1.23143087
44	MP0001968_abnormal_touch/_nociception	1.19739472
45	MP0003880_abnormal_central_pattern	1.18322830
46	MP0001186_pigmentation_phenotype	1.12367211
47	MP0002234_abnormal_pharynx_morphology	1.12325177
48	MP0005248_abnormal_Harderian_gland	1.11289314
49	MP0003077_abnormal_cell_cycle	1.09900850
50	MP0009745_abnormal_behavioral_response	1.06977850
51	MP0005409_darkened_coat_color	1.04056103
52	MP0001984_abnormal_olfaction	0.95275331
53	MP0009046_muscle_twitch	0.94008178
54	MP0002638_abnormal_pupillary_reflex	0.93315699
55	MP0005187_abnormal_penis_morphology	0.93302827
56	MP0000427_abnormal_hair_cycle	0.89454144
57	MP0002272_abnormal_nervous_system	0.88223644
58	MP0000647_abnormal_sebaceous_gland	0.85345174
59	MP0001486_abnormal_startle_reflex	0.84250345
60	MP0005197_abnormal_uvea_morphology	0.84045069
61	MP0005391_vision/eye_phenotype	0.83060804
62	MP0002064_seizures	0.82476018
63	MP0005195_abnormal_posterior_eye	0.79334377
64	MP0005645_abnormal_hypothalamus_physiol	0.77962049
65	MP0002877_abnormal_melanocyte_morpholog	0.77717341
66	MP0008872_abnormal_physiological_respon	0.75584708
67	MP0002282_abnormal_trachea_morphology	0.72642558
68	MP0004885_abnormal_endolymph	0.72577529
69	MP0002229_neurodegeneration	0.72143655
70	MP0002210_abnormal_sex_determination	0.69149667
71	MP0001529_abnormal_vocalization	0.69121706
72	MP0005646_abnormal_pituitary_gland	0.66194205
73	MP0003121_genomic_imprinting	0.65766262
74	MP0001919_abnormal_reproductive_system	0.63211390
75	MP0003635_abnormal_synaptic_transmissio	0.62511026
76	MP0002752_abnormal_somatic_nervous	0.62134012
77	MP0002161_abnormal_fertility/fecundity	0.61997762
78	MP0000631_abnormal_neuroendocrine_gland	0.61752665
79	MP0003890_abnormal_embryonic-extraembry	0.60259753
80	MP0006276_abnormal_autonomic_nervous	0.59961884
81	MP0001293_anophthalmia	0.59598898
82	MP0000026_abnormal_inner_ear	0.59407471
83	MP0002396_abnormal_hematopoietic_system	0.59335802
84	MP0001485_abnormal_pinna_reflex	0.59187553
85	MP0002751_abnormal_autonomic_nervous	0.58636135
86	MP0002177_abnormal_outer_ear	0.56983766
87	MP0002735_abnormal_chemical_nociception	0.54196579
88	MP0002909_abnormal_adrenal_gland	0.53526118
89	MP0004085_abnormal_heartbeat	0.53287143
90	MP0002067_abnormal_sensory_capabilities	0.51584447
91	MP0008007_abnormal_cellular_replicative	0.50682910
92	MP0001963_abnormal_hearing_physiology	0.50521439
93	MP0004742_abnormal_vestibular_system	0.50205509
94	MP0002882_abnormal_neuron_morphology	0.49441302
95	MP0000955_abnormal_spinal_cord	0.48694606
96	MP0000653_abnormal_sex_gland	0.48466431
97	MP0004142_abnormal_muscle_tone	0.48298798
98	MP0004957_abnormal_blastocyst_morpholog	0.46480019
99	MP0004859_abnormal_synaptic_plasticity	0.45440154
100	MP0005389_reproductive_system_phenotype	0.45106514

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the macula (HP:0008059)	5.31453749
2	Volvulus (HP:0002580)	5.30962286
3	Aplasia/Hypoplasia affecting the retina (HP:0008061)	4.91218877
4	Ocular albinism (HP:0001107)	4.70234430
5	Hypoplasia of the fovea (HP:0007750)	4.61013043
6	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.61013043
7	Iris hypopigmentation (HP:0007730)	4.42916589
8	Hyperventilation (HP:0002883)	4.21238580
9	Blue irides (HP:0000635)	4.00783737
10	Abnormality of the fovea (HP:0000493)	3.90190295
11	Hypopigmentation of the fundus (HP:0007894)	3.87129907
12	White forelock (HP:0002211)	3.57544527
13	Generalized hypopigmentation (HP:0007513)	3.55904639
14	Congenital stationary night blindness (HP:0007642)	3.51901690
15	Patchy hypopigmentation of hair (HP:0011365)	3.44835537
16	Congenital sensorineural hearing impairment (HP:0008527)	3.42160190
17	Pancreatic cysts (HP:0001737)	3.39854372
18	Bifid tongue (HP:0010297)	3.12935238
19	Pancreatic fibrosis (HP:0100732)	3.05089481
20	Frequent falls (HP:0002359)	3.04286303
21	Abnormality of the astrocytes (HP:0100707)	3.02899363
22	Astrocytoma (HP:0009592)	3.02899363
23	True hermaphroditism (HP:0010459)	2.97691140
24	Cystic liver disease (HP:0006706)	2.92925646
25	Abnormality of midbrain morphology (HP:0002418)	2.87950887
26	Molar tooth sign on MRI (HP:0002419)	2.87950887
27	Freckling (HP:0001480)	2.87780344
28	Gaze-evoked nystagmus (HP:0000640)	2.85449703
29	Glioma (HP:0009733)	2.83007382
30	Astigmatism (HP:0000483)	2.81918970
31	Chromsome breakage (HP:0040012)	2.78340793
32	Decreased central vision (HP:0007663)	2.70126062
33	Abnormal auditory evoked potentials (HP:0006958)	2.64309065
34	Amblyopia (HP:0000646)	2.62071084
35	Horizontal nystagmus (HP:0000666)	2.61419655
36	Nephronophthisis (HP:0000090)	2.55303500
37	Albinism (HP:0001022)	2.54866262
38	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.53997282
39	Absent speech (HP:0001344)	2.51616031
40	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.50257758
41	Severe visual impairment (HP:0001141)	2.47978476
42	Abnormality of the labia minora (HP:0012880)	2.45282925
43	Abnormality of macular pigmentation (HP:0008002)	2.40259279
44	Meckel diverticulum (HP:0002245)	2.38913440
45	Abnormality of the ileum (HP:0001549)	2.36930905
46	Abnormality of chromosome stability (HP:0003220)	2.36888493
47	Progressive cerebellar ataxia (HP:0002073)	2.33636062
48	Hypochromic microcytic anemia (HP:0004840)	2.31699067
49	Retinal dysplasia (HP:0007973)	2.30336132
50	Megalencephaly (HP:0001355)	2.27565975
51	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.25717447
52	Duodenal stenosis (HP:0100867)	2.23557892
53	Small intestinal stenosis (HP:0012848)	2.23557892
54	Absent/shortened dynein arms (HP:0200106)	2.22153610
55	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.22153610
56	Sloping forehead (HP:0000340)	2.20313859
57	Chronic hepatic failure (HP:0100626)	2.20117110
58	Hamartoma of the eye (HP:0010568)	2.16474464
59	Hypoplastic ischia (HP:0003175)	2.16058442
60	Bony spicule pigmentary retinopathy (HP:0007737)	2.13898897
61	Generalized hypopigmentation of hair (HP:0011358)	2.12989348
62	Focal motor seizures (HP:0011153)	2.10611703
63	Congenital hepatic fibrosis (HP:0002612)	2.07876880
64	Attenuation of retinal blood vessels (HP:0007843)	2.04889987
65	Abnormality of the renal medulla (HP:0100957)	2.03820604
66	Abnormality of the preputium (HP:0100587)	2.02141382
67	Ependymoma (HP:0002888)	2.01783493
68	Long clavicles (HP:0000890)	2.01679709
69	Cutaneous melanoma (HP:0012056)	1.99446361
70	Abnormality of chromosome segregation (HP:0002916)	1.99281719
71	Neuroendocrine neoplasm (HP:0100634)	1.97639210
72	Intestinal atresia (HP:0011100)	1.96960773
73	Small hand (HP:0200055)	1.92679417
74	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.91200906
75	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.91186176
76	Clubbing of toes (HP:0100760)	1.88338097
77	Thickened helices (HP:0000391)	1.87354789
78	Sclerocornea (HP:0000647)	1.87297451
79	Photophobia (HP:0000613)	1.83816610
80	Facial cleft (HP:0002006)	1.83316332
81	Anencephaly (HP:0002323)	1.82328882
82	Widely spaced teeth (HP:0000687)	1.82078438
83	Cupped ear (HP:0000378)	1.81457288
84	Abnormality of the ischium (HP:0003174)	1.80997305
85	Oculomotor apraxia (HP:0000657)	1.80823100
86	Absent frontal sinuses (HP:0002688)	1.80353350
87	Inability to walk (HP:0002540)	1.79524890
88	Abnormality of the duodenum (HP:0002246)	1.79197389
89	Tented upper lip vermilion (HP:0010804)	1.78685172
90	Meningioma (HP:0002858)	1.78413172
91	Neoplasm of striated muscle (HP:0009728)	1.77146527
92	Limb dystonia (HP:0002451)	1.76952953
93	Abnormality of the nasal septum (HP:0000419)	1.76078951
94	Tachypnea (HP:0002789)	1.75991632
95	Renal dysplasia (HP:0000110)	1.75936284
96	Focal seizures (HP:0007359)	1.74939210
97	Fibular hypoplasia (HP:0003038)	1.74738888
98	Drooling (HP:0002307)	1.73906119
99	Neoplasm of the peripheral nervous system (HP:0100007)	1.73786243
100	Male pseudohermaphroditism (HP:0000037)	1.72206477

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	4.29019461
2	PLK4	4.14917328
3	WNK3	3.99724652
4	WEE1	3.82206730
5	FRK	3.42329505
6	MARK1	3.29847486
7	MAPK13	2.75089190
8	PLK2	2.70421833
9	NEK2	2.29447086
10	PNCK	2.28555345
11	ACVR1B	2.06004816
12	MAP4K2	2.03414857
13	INSRR	1.84723661
14	STK38L	1.80106140
15	PTK2B	1.77736229
16	PRKD3	1.75972163
17	UHMK1	1.52552429
18	BRD4	1.49794701
19	AKT3	1.46368230
20	PDK2	1.41551957
21	SIK2	1.39638021
22	MARK3	1.37838480
23	STK3	1.29407444
24	MST1R	1.26134458
25	BMPR2	1.25250044
26	STK38	1.23373087
27	CCNB1	1.20952624
28	LATS1	1.19601828
29	BMPR1B	1.15573022
30	BRSK2	1.13492359
31	NUAK1	1.13436461
32	ZAK	1.10302166
33	FGR	1.08915073
34	ADRBK2	1.07501289
35	PLK3	1.01692881
36	SRPK1	1.00148646
37	PIK3CG	0.99224546
38	TRIM28	0.95448843
39	BRSK1	0.89579117
40	CSNK1G2	0.87103400
41	ERBB2	0.80315261
42	CASK	0.80236254
43	MKNK2	0.79897134
44	GRK5	0.77755763
45	EIF2AK1	0.76147862
46	PRKCH	0.75437515
47	ERBB3	0.73786018
48	CSNK1G3	0.73245251
49	PKN1	0.72385896
50	SIK3	0.72328829
51	PRKCG	0.71265944
52	PBK	0.70621304
53	CAMK2A	0.70153706
54	TYK2	0.67467050
55	BUB1	0.66466196
56	YES1	0.65511640
57	ATR	0.65205162
58	MAP3K12	0.65167506
59	PLK1	0.63220681
60	CDK7	0.62286691
61	CSNK1G1	0.61386668
62	PRKCE	0.60440066
63	EIF2AK3	0.58653196
64	ATM	0.58479708
65	DDR2	0.58315923
66	DYRK2	0.57909416
67	DYRK1A	0.54163932
68	GRK7	0.53670961
69	CDK3	0.53604485
70	MINK1	0.53531625
71	FGFR2	0.53411719
72	CSNK1D	0.52845071
73	TNIK	0.52763232
74	GRK1	0.52483241
75	CSNK1A1L	0.52032927
76	CHEK2	0.50569092
77	PAK3	0.50360658
78	CAMK1G	0.49098953
79	MET	0.47695043
80	ADRBK1	0.47499017
81	CAMK4	0.47252648
82	FER	0.46979875
83	CLK1	0.46877694
84	SGK2	0.46797353
85	CSNK1A1	0.46097606
86	KIT	0.45552190
87	NTRK3	0.45369916
88	NEK6	0.44891723
89	CSF1R	0.44803131
90	PINK1	0.43520349
91	PRKACB	0.43154253
92	CDC7	0.41973920
93	TIE1	0.39663541
94	FLT3	0.39002630
95	CDK1	0.37951752
96	DYRK3	0.37587854
97	VRK1	0.37132986
98	CAMK1	0.36939690
99	PRKG1	0.36629725
100	GSK3B	0.36312581

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	6.19936543
2	Homologous recombination_Homo sapiens_hsa03440	4.30682819
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.16993901
4	Mismatch repair_Homo sapiens_hsa03430	3.10793009
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.82893953
6	Protein export_Homo sapiens_hsa03060	2.50642825
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.49779907
8	Phototransduction_Homo sapiens_hsa04744	2.11169989
9	Propanoate metabolism_Homo sapiens_hsa00640	2.01309698
10	Selenocompound metabolism_Homo sapiens_hsa00450	1.94000967
11	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.86207122
12	Basal transcription factors_Homo sapiens_hsa03022	1.83759358
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.77748551
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.75461748
15	Nicotine addiction_Homo sapiens_hsa05033	1.72800398
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.72367174
17	Olfactory transduction_Homo sapiens_hsa04740	1.66582534
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.65102088
19	Collecting duct acid secretion_Homo sapiens_hsa04966	1.41220885
20	Tyrosine metabolism_Homo sapiens_hsa00350	1.39295935
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.35386856
22	DNA replication_Homo sapiens_hsa03030	1.35037350
23	Taste transduction_Homo sapiens_hsa04742	1.32824168
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.31631863
25	RNA degradation_Homo sapiens_hsa03018	1.29848069
26	Fatty acid degradation_Homo sapiens_hsa00071	1.24927900
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21316581
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.19152802
29	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.17528008
30	Oocyte meiosis_Homo sapiens_hsa04114	1.13346101
31	Butanoate metabolism_Homo sapiens_hsa00650	1.11328285
32	Proteasome_Homo sapiens_hsa03050	1.10356856
33	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.08144305
34	One carbon pool by folate_Homo sapiens_hsa00670	1.06315359
35	Fatty acid metabolism_Homo sapiens_hsa01212	1.06148211
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02433941
37	Tryptophan metabolism_Homo sapiens_hsa00380	0.97540286
38	RNA transport_Homo sapiens_hsa03013	0.96010542
39	Cell cycle_Homo sapiens_hsa04110	0.95986748
40	Circadian rhythm_Homo sapiens_hsa04710	0.95738759
41	Circadian entrainment_Homo sapiens_hsa04713	0.95702411
42	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.93335870
43	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.92721932
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.92388216
45	RNA polymerase_Homo sapiens_hsa03020	0.91694545
46	Parkinsons disease_Homo sapiens_hsa05012	0.89558592
47	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.87558531
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.85460204
49	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.84377196
50	Huntingtons disease_Homo sapiens_hsa05016	0.83473496
51	Sphingolipid metabolism_Homo sapiens_hsa00600	0.82118861
52	Linoleic acid metabolism_Homo sapiens_hsa00591	0.80292871
53	Glutathione metabolism_Homo sapiens_hsa00480	0.79887143
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.79635429
55	Amphetamine addiction_Homo sapiens_hsa05031	0.79424634
56	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.78627592
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.77745427
58	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74383097
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.71627951
60	Morphine addiction_Homo sapiens_hsa05032	0.70548500
61	Serotonergic synapse_Homo sapiens_hsa04726	0.67725927
62	p53 signaling pathway_Homo sapiens_hsa04115	0.65797005
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.63722972
64	Oxidative phosphorylation_Homo sapiens_hsa00190	0.63602988
65	Insulin secretion_Homo sapiens_hsa04911	0.63515889
66	Asthma_Homo sapiens_hsa05310	0.60990287
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59691698
68	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.57463415
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.57300974
70	mRNA surveillance pathway_Homo sapiens_hsa03015	0.57226065
71	Cocaine addiction_Homo sapiens_hsa05030	0.56474732
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.55013931
73	Salivary secretion_Homo sapiens_hsa04970	0.54840258
74	Base excision repair_Homo sapiens_hsa03410	0.54059964
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.53391720
76	Caffeine metabolism_Homo sapiens_hsa00232	0.50275136
77	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.50205264
78	Retinol metabolism_Homo sapiens_hsa00830	0.49625285
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.46650170
80	Histidine metabolism_Homo sapiens_hsa00340	0.46550615
81	Dopaminergic synapse_Homo sapiens_hsa04728	0.46143990
82	Purine metabolism_Homo sapiens_hsa00230	0.45639994
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.44834324
84	Metabolic pathways_Homo sapiens_hsa01100	0.43860204
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41645227
86	Long-term depression_Homo sapiens_hsa04730	0.41197675
87	ABC transporters_Homo sapiens_hsa02010	0.38369364
88	GABAergic synapse_Homo sapiens_hsa04727	0.38345375
89	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.37061974
90	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36530071
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.35452233
92	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.33014715
93	Melanoma_Homo sapiens_hsa05218	0.31872110
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31607938
95	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.29033771
96	Alzheimers disease_Homo sapiens_hsa05010	0.28228484
97	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.27974820
98	Melanogenesis_Homo sapiens_hsa04916	0.27255890
99	PPAR signaling pathway_Homo sapiens_hsa03320	0.25440105
100	Allograft rejection_Homo sapiens_hsa05330	0.25153975

C6ORF10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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