ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein localization to endosome (GO:0036010)	4.23796692
2	regulation of early endosome to late endosome transport (GO:2000641)	3.87526594
3	NADH metabolic process (GO:0006734)	3.65754278
4	negative regulation of erythrocyte differentiation (GO:0045647)	3.55823310
5	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.54303874
6	regulation of cholesterol homeostasis (GO:2000188)	3.47304200
7	focal adhesion assembly (GO:0048041)	3.42338152
8	cell-substrate adherens junction assembly (GO:0007045)	3.42338152
9	adherens junction assembly (GO:0034333)	3.34377201
10	COPI coating of Golgi vesicle (GO:0048205)	3.20820338
11	Golgi transport vesicle coating (GO:0048200)	3.20820338
12	creatine metabolic process (GO:0006600)	3.20396328
13	urea cycle (GO:0000050)	3.07093426
14	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.04591630
15	urea metabolic process (GO:0019627)	3.03168370
16	stress fiber assembly (GO:0043149)	3.00466551
17	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.91883087
18	pinocytosis (GO:0006907)	2.90337381
19	nitrogen cycle metabolic process (GO:0071941)	2.85747007
20	cell-substrate junction assembly (GO:0007044)	2.83036871
21	embryonic process involved in female pregnancy (GO:0060136)	2.82126819
22	dicarboxylic acid biosynthetic process (GO:0043650)	2.81680028
23	oxaloacetate metabolic process (GO:0006107)	2.80591640
24	3-UTR-mediated mRNA stabilization (GO:0070935)	2.79088365
25	mannose metabolic process (GO:0006013)	2.78067014
26	low-density lipoprotein particle clearance (GO:0034383)	2.77906397
27	sarcoplasmic reticulum calcium ion transport (GO:0070296)	2.76877233
28	positive regulation of membrane protein ectodomain proteolysis (GO:0051044)	2.75438283
29	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.72108100
30	positive regulation of myotube differentiation (GO:0010831)	2.71617377
31	cellular protein complex localization (GO:0034629)	2.70077263
32	barbed-end actin filament capping (GO:0051016)	2.67491574
33	fructose metabolic process (GO:0006000)	2.65701584
34	activation of MAPKKK activity (GO:0000185)	2.62420074
35	actin-myosin filament sliding (GO:0033275)	2.59846874
36	muscle filament sliding (GO:0030049)	2.59846874
37	cellular response to thyroid hormone stimulus (GO:0097067)	2.57460605
38	negative regulation of fibrinolysis (GO:0051918)	2.56722531
39	response to thyroid hormone (GO:0097066)	2.53878351
40	apoptotic process involved in morphogenesis (GO:0060561)	2.52616542
41	response to laminar fluid shear stress (GO:0034616)	2.50957930
42	epithelial cell-cell adhesion (GO:0090136)	2.50546422
43	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	2.50371869
44	protein-lipid complex assembly (GO:0065005)	2.49614591
45	modulation by symbiont of host cellular process (GO:0044068)	2.48952211
46	tricarboxylic acid metabolic process (GO:0072350)	2.47514045
47	negative regulation of cell size (GO:0045792)	2.47055387
48	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.45601153
49	activation of Rac GTPase activity (GO:0032863)	2.44431299
50	skeletal muscle contraction (GO:0003009)	2.43367888
51	endoplasmic reticulum calcium ion homeostasis (GO:0032469)	2.42737499
52	regulation of fatty acid biosynthetic process (GO:0042304)	2.42534210
53	gluconeogenesis (GO:0006094)	2.41808268
54	regulation of ARF protein signal transduction (GO:0032012)	2.41547646
55	positive regulation of extracellular matrix organization (GO:1903055)	2.38759571
56	positive regulation of nuclease activity (GO:0032075)	2.38409618
57	sodium ion export (GO:0071436)	2.37496988
58	maternal placenta development (GO:0001893)	2.37348994
59	negative regulation of protein localization to plasma membrane (GO:1903077)	2.35638603
60	positive regulation of cellular amide metabolic process (GO:0034250)	2.35456990
61	negative regulation of necroptotic process (GO:0060546)	2.34873746
62	regulation of cholesterol biosynthetic process (GO:0045540)	2.34816493
63	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	2.34456338
64	pentose-phosphate shunt (GO:0006098)	2.33983309
65	regulation of histone H3-K27 methylation (GO:0061085)	2.33895286
66	desmosome organization (GO:0002934)	2.33818101
67	epithelial cell differentiation involved in prostate gland development (GO:0060742)	2.33336176
68	response to mercury ion (GO:0046689)	2.32543792
69	hypotonic response (GO:0006971)	2.30874656
70	positive regulation of receptor recycling (GO:0001921)	2.30695638
71	hexose biosynthetic process (GO:0019319)	2.30404222
72	monosaccharide biosynthetic process (GO:0046364)	2.30272513
73	regulation of glucose import in response to insulin stimulus (GO:2001273)	2.29050972
74	regulation of cholesterol storage (GO:0010885)	2.28954519
75	negative regulation of lipid transport (GO:0032369)	2.28874874
76	surfactant homeostasis (GO:0043129)	2.28753837
77	glucose 6-phosphate metabolic process (GO:0051156)	2.25789895
78	cortical actin cytoskeleton organization (GO:0030866)	2.23154134
79	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)	2.23110751
80	skin morphogenesis (GO:0043589)	2.22973115
81	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.22750723
82	basement membrane organization (GO:0071711)	2.22040304
83	regulation of nucleobase-containing compound transport (GO:0032239)	2.21364500
84	positive regulation of Rap GTPase activity (GO:0032854)	2.21187145
85	glycogen catabolic process (GO:0005980)	2.20363016
86	very-low-density lipoprotein particle assembly (GO:0034379)	2.19441901
87	regulation of extracellular matrix disassembly (GO:0010715)	2.18970104
88	ER-nucleus signaling pathway (GO:0006984)	2.18538372
89	endoplasmic reticulum unfolded protein response (GO:0030968)	2.17506879
90	regulation of fibrinolysis (GO:0051917)	2.17386042
91	regulation of NFAT protein import into nucleus (GO:0051532)	2.17160805
92	regulation of nuclease activity (GO:0032069)	2.17136893
93	protein complex localization (GO:0031503)	2.16381773
94	striated muscle contraction (GO:0006941)	2.15854737
95	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	2.15575719
96	positive regulation of protein dephosphorylation (GO:0035307)	2.15555576
97	peptidyl-threonine phosphorylation (GO:0018107)	2.15123461
98	fatty acid homeostasis (GO:0055089)	2.14566922
99	regulation of necroptotic process (GO:0060544)	2.13010845
100	cellular hyperosmotic response (GO:0071474)	2.12896318

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	3.44370522
2	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.75974718
3	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.58486830
4	MYC_22102868_ChIP-Seq_BL_Human	2.57008569
5	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.49406938
6	LXR_22292898_ChIP-Seq_THP-1_Human	2.40707505
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.35038158
8	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.30230553
9	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.24905748
10	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.21106222
11	TCF7_22412390_ChIP-Seq_EML_Mouse	2.16193682
12	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.15679699
13	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.15081659
14	CLOCK_20551151_ChIP-Seq_293T_Human	2.14887629
15	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.05092069
16	RACK7_27058665_Chip-Seq_MCF-7_Human	2.04268685
17	VDR_21846776_ChIP-Seq_THP-1_Human	2.02431114
18	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.92684720
19	ZNF263_19887448_ChIP-Seq_K562_Human	1.92384898
20	KDM2B_26808549_Chip-Seq_DND41_Human	1.88382125
21	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.87523780
22	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.84647052
23	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.76689229
24	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.75567088
25	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.74317602
26	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.72499506
27	KDM2B_26808549_Chip-Seq_K562_Human	1.70445350
28	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.65583061
29	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.62640505
30	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.55655074
31	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.51694852
32	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.50691335
33	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.49750408
34	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.49563216
35	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.48208429
36	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.46447171
37	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.43214172
38	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.40927370
39	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.39503242
40	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.39453937
41	MAF_26560356_Chip-Seq_TH1_Human	1.39233795
42	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.37292803
43	GATA1_19941826_ChIP-Seq_K562_Human	1.36544281
44	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.34982477
45	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.34920485
46	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.34442749
47	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.33665661
48	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.33665661
49	NCOR1_26117541_ChIP-Seq_K562_Human	1.33191361
50	SMC4_20622854_ChIP-Seq_HELA_Human	1.32951697
51	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.31351358
52	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.31333507
53	VDR_24763502_ChIP-Seq_THP-1_Human	1.31102287
54	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.30366465
55	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.30095180
56	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.29431166
57	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.26345147
58	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.26240956
59	* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.26114021
60	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.25284230
61	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.25217409
62	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.24435660
63	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.23790484
64	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.23660298
65	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.22078987
66	ATF3_27146783_Chip-Seq_COLON_Human	1.21578970
67	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.20673725
68	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.19589877
69	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.19038951
70	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.18809719
71	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.17947621
72	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.17391253
73	CREB1_26743006_Chip-Seq_LNCaP_Human	1.15554758
74	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.13198291
75	SPI1_23127762_ChIP-Seq_K562_Human	1.12534499
76	GATA1_22025678_ChIP-Seq_K562_Human	1.12211437
77	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.11565695
78	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.11447994
79	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.10614241
80	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.10467875
81	P68_20966046_ChIP-Seq_HELA_Human	1.09561502
82	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.08239322
83	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.08047963
84	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.07273688
85	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.05946459
86	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.05767864
87	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.04786198
88	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.04189436
89	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.04150608
90	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.04017198
91	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.03068083
92	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	0.99597505
93	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.99532243
94	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.99160252
95	MAF_26560356_Chip-Seq_TH2_Human	0.98024152
96	UTX_26944678_Chip-Seq_JUKART_Human	0.97669530
97	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.96705459
98	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.96511901
99	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.96206286
100	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.95601476

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	4.41123362
2	MP0003705_abnormal_hypodermis_morpholog	3.56145294
3	MP0009840_abnormal_foam_cell	3.14078067
4	MP0010234_abnormal_vibrissa_follicle	2.97198181
5	MP0003191_abnormal_cellular_cholesterol	2.75127797
6	MP0005058_abnormal_lysosome_morphology	2.63534389
7	MP0004233_abnormal_muscle_weight	2.58639021
8	MP0002139_abnormal_hepatobiliary_system	2.54680034
9	MP0000751_myopathy	2.47037911
10	MP0003566_abnormal_cell_adhesion	2.34491475
11	MP0002877_abnormal_melanocyte_morpholog	2.10306565
12	MP0008260_abnormal_autophagy	1.98788413
13	MP0004185_abnormal_adipocyte_glucose	1.93942408
14	MP0003303_peritoneal_inflammation	1.93801792
15	MP0005076_abnormal_cell_differentiation	1.93767077
16	MP0000747_muscle_weakness	1.89545378
17	MP0003453_abnormal_keratinocyte_physiol	1.85386598
18	MP0004510_myositis	1.81327402
19	MP0004087_abnormal_muscle_fiber	1.79962465
20	MP0005666_abnormal_adipose_tissue	1.76781473
21	MP0004036_abnormal_muscle_relaxation	1.72046392
22	MP0002796_impaired_skin_barrier	1.70969550
23	MP0003646_muscle_fatigue	1.69951477
24	MP0003300_gastrointestinal_ulcer	1.69890150
25	MP0003091_abnormal_cell_migration	1.69748885
26	MP0000749_muscle_degeneration	1.66902190
27	MP0005409_darkened_coat_color	1.59471960
28	MP0003656_abnormal_erythrocyte_physiolo	1.59377695
29	MP0000759_abnormal_skeletal_muscle	1.57635526
30	MP0005375_adipose_tissue_phenotype	1.54860263
31	MP0005257_abnormal_intraocular_pressure	1.48320311
32	MP0002269_muscular_atrophy	1.41439167
33	MP0000003_abnormal_adipose_tissue	1.38900388
34	MP0010630_abnormal_cardiac_muscle	1.38652125
35	MP0003172_abnormal_lysosome_physiology	1.38241659
36	MP0008438_abnormal_cutaneous_collagen	1.35682056
37	MP0004947_skin_inflammation	1.33998987
38	MP0005330_cardiomyopathy	1.32690414
39	MP0000733_abnormal_muscle_development	1.30799593
40	MP0003329_amyloid_beta_deposits	1.30322283
41	MP0001348_abnormal_lacrimal_gland	1.29854788
42	MP0004130_abnormal_muscle_cell	1.27785922
43	MP0002971_abnormal_brown_adipose	1.26951195
44	MP0010352_gastrointestinal_tract_polyps	1.24291096
45	MP0001849_ear_inflammation	1.22425216
46	MP0002106_abnormal_muscle_physiology	1.21438083
47	MP0005670_abnormal_white_adipose	1.18312485
48	MP0003075_altered_response_to	1.15263672
49	MP0005464_abnormal_platelet_physiology	1.14996484
50	MP0006138_congestive_heart_failure	1.14669767
51	MP0004084_abnormal_cardiac_muscle	1.13760279
52	MP0004264_abnormal_extraembryonic_tissu	1.12897743
53	MP0000750_abnormal_muscle_regeneration	1.10885602
54	MP0003436_decreased_susceptibility_to	1.10445618
55	MP0000858_altered_metastatic_potential	1.09672674
56	MP0005023_abnormal_wound_healing	1.08629852
57	MP0002332_abnormal_exercise_endurance	1.06656157
58	MP0009672_abnormal_birth_weight	1.03813694
59	MP0005365_abnormal_bile_salt	1.02137910
60	MP0009780_abnormal_chondrocyte_physiolo	1.01712378
61	MP0000604_amyloidosis	1.01674963
62	MP0001661_extended_life_span	1.00339141
63	MP0004858_abnormal_nervous_system	0.99677330
64	MP0003828_pulmonary_edema	0.98222915
65	MP0005501_abnormal_skin_physiology	0.97854742
66	MP0002998_abnormal_bone_remodeling	0.96840852
67	MP0008874_decreased_physiological_sensi	0.95845722
68	MP0001915_intracranial_hemorrhage	0.94203639
69	MP0000609_abnormal_liver_physiology	0.91970117
70	MP0003690_abnormal_glial_cell	0.91358481
71	MP0003221_abnormal_cardiomyocyte_apopto	0.91202727
72	MP0005369_muscle_phenotype	0.91120587
73	MP0003045_fibrosis	0.89920713
74	MP0003950_abnormal_plasma_membrane	0.89815382
75	MP0004272_abnormal_basement_membrane	0.87651486
76	MP0009115_abnormal_fat_cell	0.86064141
77	MP0005166_decreased_susceptibility_to	0.85966532
78	MP0002089_abnormal_postnatal_growth/wei	0.85407019
79	MP0009333_abnormal_splenocyte_physiolog	0.85362318
80	MP0000685_abnormal_immune_system	0.85111272
81	MP0000678_abnormal_parathyroid_gland	0.84405166
82	MP0005621_abnormal_cell_physiology	0.82532298
83	MP0002972_abnormal_cardiac_muscle	0.82335341
84	MP0001730_embryonic_growth_arrest	0.81585031
85	MP0003868_abnormal_feces_composition	0.78811604
86	MP0002060_abnormal_skin_morphology	0.76663718
87	MP0003879_abnormal_hair_cell	0.76440530
88	MP0003763_abnormal_thymus_physiology	0.75041975
89	MP0005165_increased_susceptibility_to	0.73556932
90	MP0005275_abnormal_skin_tensile	0.72732996
91	MP0005584_abnormal_enzyme/coenzyme_acti	0.72043679
92	MP0001851_eye_inflammation	0.70404584
93	MP0002166_altered_tumor_susceptibility	0.70114850
94	MP0004145_abnormal_muscle_electrophysio	0.70090397
95	MP0010329_abnormal_lipoprotein_level	0.69828056
96	MP0003183_abnormal_peptide_metabolism	0.69695794
97	MP0001853_heart_inflammation	0.68176256
98	MP0000767_abnormal_smooth_muscle	0.67849933
99	MP0001216_abnormal_epidermal_layer	0.67638619
100	MP0002118_abnormal_lipid_homeostasis	0.65636059

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Exercise-induced myalgia (HP:0003738)	4.16869602
2	Muscle fiber inclusion bodies (HP:0100299)	3.74314253
3	Nemaline bodies (HP:0003798)	3.71350215
4	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.66469010
5	Centrally nucleated skeletal muscle fibers (HP:0003687)	3.58126936
6	Increased connective tissue (HP:0009025)	3.35933124
7	Type 1 muscle fiber predominance (HP:0003803)	3.27497630
8	Distal lower limb muscle weakness (HP:0009053)	3.21779794
9	Deep venous thrombosis (HP:0002625)	2.95468013
10	Myopathic facies (HP:0002058)	2.95066170
11	Abnormality of skeletal muscle fiber size (HP:0012084)	2.83767319
12	Distal lower limb amyotrophy (HP:0008944)	2.82984308
13	Hyporeflexia of lower limbs (HP:0002600)	2.81714582
14	Increased variability in muscle fiber diameter (HP:0003557)	2.65442893
15	Dysmetric saccades (HP:0000641)	2.64783054
16	Asymmetric septal hypertrophy (HP:0001670)	2.64587224
17	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.57823054
18	Rhabdomyolysis (HP:0003201)	2.56701084
19	Abnormal gallbladder physiology (HP:0012438)	2.50190167
20	Cholecystitis (HP:0001082)	2.50190167
21	EMG: myopathic abnormalities (HP:0003458)	2.47519602
22	Abnormality of the Achilles tendon (HP:0005109)	2.41968404
23	Exercise-induced muscle cramps (HP:0003710)	2.41406197
24	Achilles tendon contracture (HP:0001771)	2.40057506
25	Muscle fiber splitting (HP:0003555)	2.32032544
26	Difficulty running (HP:0009046)	2.21307139
27	Round ear (HP:0100830)	2.18510048
28	Abnormality of the left ventricular outflow tract (HP:0011103)	2.15473539
29	Subaortic stenosis (HP:0001682)	2.15473539
30	Vertebral compression fractures (HP:0002953)	2.13425548
31	Lower limb amyotrophy (HP:0007210)	2.13033927
32	Myoglobinuria (HP:0002913)	2.11370325
33	Obstructive sleep apnea (HP:0002870)	2.09376628
34	Ulnar deviation of the wrist (HP:0003049)	2.09108297
35	Muscle stiffness (HP:0003552)	2.06100937
36	Bundle branch block (HP:0011710)	2.03851218
37	Mildly elevated creatine phosphokinase (HP:0008180)	2.03331607
38	Abnormality of complement system (HP:0005339)	2.02197276
39	Cerebral aneurysm (HP:0004944)	2.01847031
40	Fatigue (HP:0012378)	2.00317634
41	Polycythemia (HP:0001901)	1.99518721
42	Cerebral inclusion bodies (HP:0100314)	1.98362169
43	Protrusio acetabuli (HP:0003179)	1.97231664
44	Sudden death (HP:0001699)	1.96961872
45	Systemic lupus erythematosus (HP:0002725)	1.95764406
46	Hemorrhage of the eye (HP:0011885)	1.95261960
47	Myocardial infarction (HP:0001658)	1.94577726
48	Ankyloglossia (HP:0010296)	1.94094323
49	Foot dorsiflexor weakness (HP:0009027)	1.92987564
50	Reticulocytosis (HP:0001923)	1.91323659
51	Ventricular tachycardia (HP:0004756)	1.91252821
52	Neck muscle weakness (HP:0000467)	1.90792705
53	Spinal rigidity (HP:0003306)	1.90577725
54	Flat acetabular roof (HP:0003180)	1.88823360
55	Xanthomatosis (HP:0000991)	1.87502545
56	Gastrointestinal stroma tumor (HP:0100723)	1.85306177
57	Complement deficiency (HP:0004431)	1.85131470
58	Right ventricular cardiomyopathy (HP:0011663)	1.84367385
59	Cholelithiasis (HP:0001081)	1.84054936
60	Advanced eruption of teeth (HP:0006288)	1.82891932
61	Eczematoid dermatitis (HP:0000976)	1.81785215
62	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.81718564
63	Osteolytic defects of the hand bones (HP:0009699)	1.81718564
64	Upper limb amyotrophy (HP:0009129)	1.81246681
65	Distal upper limb amyotrophy (HP:0007149)	1.81246681
66	Abnormality of the fingertips (HP:0001211)	1.80755813
67	Ragged-red muscle fibers (HP:0003200)	1.80680041
68	Hyperacusis (HP:0010780)	1.78500690
69	Segmental peripheral demyelination/remyelination (HP:0003481)	1.74392373
70	Abnormality of the foot musculature (HP:0001436)	1.74160156
71	Progressive external ophthalmoplegia (HP:0000590)	1.73312243
72	Distal arthrogryposis (HP:0005684)	1.72955954
73	Progressive muscle weakness (HP:0003323)	1.71490415
74	Bulbar palsy (HP:0001283)	1.71464462
75	Neurofibrillary tangles (HP:0002185)	1.70980950
76	Abnormality of the salivary glands (HP:0010286)	1.68598157
77	Axonal loss (HP:0003447)	1.68297347
78	Dysostosis multiplex (HP:0000943)	1.66746440
79	Difficulty climbing stairs (HP:0003551)	1.65681167
80	Abnormal atrioventricular conduction (HP:0005150)	1.63537101
81	Abnormality of the common coagulation pathway (HP:0010990)	1.63485200
82	Cellulitis (HP:0100658)	1.63231241
83	Atrioventricular block (HP:0001678)	1.62283166
84	Glomerulonephritis (HP:0000099)	1.61785324
85	Decreased motor nerve conduction velocity (HP:0003431)	1.61285177
86	Hypercholesterolemia (HP:0003124)	1.60002693
87	Abnormality of liposaccharide metabolism (HP:0010968)	1.59815635
88	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.59815635
89	Abnormality of glycolipid metabolism (HP:0010969)	1.59815635
90	Premature rupture of membranes (HP:0001788)	1.59516293
91	Slow saccadic eye movements (HP:0000514)	1.58745504
92	Aneurysm (HP:0002617)	1.58738989
93	Back pain (HP:0003418)	1.57706492
94	Abnormal gallbladder morphology (HP:0012437)	1.57345695
95	Colitis (HP:0002583)	1.57229372
96	Bowel incontinence (HP:0002607)	1.56927850
97	Frequent falls (HP:0002359)	1.55692791
98	Emphysema (HP:0002097)	1.53512485
99	Supranuclear gaze palsy (HP:0000605)	1.53499214
100	Mucopolysacchariduria (HP:0008155)	1.53157850

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PRPF4B	3.96694265
2	TRIB3	3.53866855
3	EEF2K	3.22818922
4	TTN	2.73060948
5	RIPK1	2.61287721
6	SMG1	2.46462817
7	KSR2	2.43717379
8	ICK	2.41468943
9	IRAK3	2.29346798
10	ERN1	2.24271049
11	CDK12	2.08812536
12	FGFR4	2.08502914
13	RIPK4	1.95176216
14	MAP3K13	1.83872115
15	SIK1	1.72252297
16	MAP2K3	1.69446362
17	OBSCN	1.67508139
18	LATS2	1.64526508
19	MAP3K9	1.56077649
20	MAP3K2	1.49078939
21	MAP3K3	1.48143751
22	ARAF	1.45582910
23	TAOK2	1.34188495
24	MAP3K1	1.33066239
25	PDGFRA	1.24766727
26	PDPK1	1.23847119
27	PHKG2	1.22783539
28	PHKG1	1.22783539
29	MAPK12	1.10925794
30	STK24	1.10154115
31	MAP3K10	1.09984849
32	MAPK11	1.06016859
33	FGFR3	1.05501599
34	DMPK	0.97237451
35	NME2	0.96634061
36	TYK2	0.96354542
37	BMX	0.95304117
38	CDC42BPA	0.89192587
39	LMTK2	0.88832369
40	MAP3K14	0.88223323
41	MTOR	0.88081459
42	SGK3	0.87943734
43	EPHA2	0.85893385
44	PDK1	0.85566776
45	MAP3K8	0.84520393
46	TESK1	0.83983275
47	SCYL2	0.81050319
48	MARK2	0.80691579
49	RAF1	0.78662770
50	KSR1	0.77695611
51	TAOK1	0.76385446
52	MST1R	0.75126515
53	PAK4	0.74338120
54	BRAF	0.73641399
55	JAK3	0.73272665
56	TRPM7	0.72621568
57	EPHB1	0.72259714
58	NEK9	0.70826862
59	TBK1	0.70666496
60	JAK1	0.69021638
61	ZAP70	0.67128010
62	STK38	0.65948313
63	WNK1	0.65905396
64	IRAK2	0.65363464
65	PKN2	0.63990519
66	MAP4K1	0.63470243
67	MOS	0.60785926
68	PTK6	0.60752724
69	RET	0.59424049
70	MAP3K11	0.59147455
71	RPS6KA2	0.58691594
72	DDR2	0.57967350
73	MAPKAPK3	0.57232609
74	MAP3K7	0.55020276
75	MAP2K1	0.54958630
76	MAP3K6	0.54825842
77	PTK2	0.54091998
78	ALK	0.53705180
79	CDK6	0.52573796
80	RPS6KC1	0.51113355
81	RPS6KL1	0.51113355
82	PRKG2	0.50233645
83	CDK4	0.49935402
84	SIK3	0.49539298
85	CAMK1D	0.49441172
86	RPS6KB2	0.47750197
87	PRKD2	0.46882732
88	LRRK2	0.46266878
89	PRKAA2	0.46136934
90	HIPK2	0.45794576
91	AKT2	0.45685402
92	IRAK4	0.45536838
93	JAK2	0.43711952
94	TYRO3	0.43059319
95	PRKD3	0.42871085
96	MAPK10	0.39576989
97	CAMK4	0.37637431
98	MAPK7	0.37615473
99	MELK	0.31288713
100	CSK	0.30543667

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.74235300
2	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.54446375
3	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.16974621
4	Other glycan degradation_Homo sapiens_hsa00511	2.09415272
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.03561545
6	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.71467032
7	Pentose phosphate pathway_Homo sapiens_hsa00030	1.70818277
8	Insulin signaling pathway_Homo sapiens_hsa04910	1.64530682
9	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.59450956
10	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.58860123
11	Prion diseases_Homo sapiens_hsa05020	1.53787254
12	Acute myeloid leukemia_Homo sapiens_hsa05221	1.53533796
13	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.43247388
14	VEGF signaling pathway_Homo sapiens_hsa04370	1.41811392
15	Non-small cell lung cancer_Homo sapiens_hsa05223	1.39692149
16	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.35860852
17	Renal cell carcinoma_Homo sapiens_hsa05211	1.34683100
18	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.30068715
19	Carbon metabolism_Homo sapiens_hsa01200	1.29939650
20	Long-term potentiation_Homo sapiens_hsa04720	1.29760727
21	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.28826862
22	Thyroid cancer_Homo sapiens_hsa05216	1.20351995
23	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.17032701
24	GnRH signaling pathway_Homo sapiens_hsa04912	1.16099955
25	Pancreatic cancer_Homo sapiens_hsa05212	1.14204602
26	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.13965472
27	Insulin resistance_Homo sapiens_hsa04931	1.13587296
28	AMPK signaling pathway_Homo sapiens_hsa04152	1.13553691
29	Complement and coagulation cascades_Homo sapiens_hsa04610	1.13507506
30	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.11536265
31	Phenylalanine metabolism_Homo sapiens_hsa00360	1.10868971
32	Glioma_Homo sapiens_hsa05214	1.10034829
33	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.09143551
34	Endometrial cancer_Homo sapiens_hsa05213	1.07755890
35	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.03673887
36	Bladder cancer_Homo sapiens_hsa05219	1.03217164
37	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.01012172
38	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.00870517
39	Glucagon signaling pathway_Homo sapiens_hsa04922	0.98346435
40	PPAR signaling pathway_Homo sapiens_hsa03320	0.96655614
41	Galactose metabolism_Homo sapiens_hsa00052	0.95010955
42	ErbB signaling pathway_Homo sapiens_hsa04012	0.94191947
43	mTOR signaling pathway_Homo sapiens_hsa04150	0.92510026
44	Osteoclast differentiation_Homo sapiens_hsa04380	0.92441291
45	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.92354970
46	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.91195795
47	Focal adhesion_Homo sapiens_hsa04510	0.89405805
48	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.87822844
49	Amoebiasis_Homo sapiens_hsa05146	0.87573275
50	Proteoglycans in cancer_Homo sapiens_hsa05205	0.86862254
51	Hepatitis C_Homo sapiens_hsa05160	0.86227759
52	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.85368184
53	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.84564681
54	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.84101586
55	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.82757302
56	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.81811564
57	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.81153286
58	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.80819680
59	Arginine and proline metabolism_Homo sapiens_hsa00330	0.79761273
60	Bile secretion_Homo sapiens_hsa04976	0.78957193
61	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.78814819
62	Adherens junction_Homo sapiens_hsa04520	0.78267049
63	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.77884963
64	Toxoplasmosis_Homo sapiens_hsa05145	0.75939688
65	Influenza A_Homo sapiens_hsa05164	0.75721345
66	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.75586426
67	Prolactin signaling pathway_Homo sapiens_hsa04917	0.75247377
68	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.74699755
69	Leishmaniasis_Homo sapiens_hsa05140	0.74304914
70	Estrogen signaling pathway_Homo sapiens_hsa04915	0.73499920
71	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.73401835
72	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.73356997
73	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.72093093
74	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.71507292
75	Lysosome_Homo sapiens_hsa04142	0.70977857
76	Viral myocarditis_Homo sapiens_hsa05416	0.69912867
77	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.69801964
78	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.66042694
79	Apoptosis_Homo sapiens_hsa04210	0.65941924
80	Endocytosis_Homo sapiens_hsa04144	0.65404615
81	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.64621482
82	Prostate cancer_Homo sapiens_hsa05215	0.64168515
83	Hepatitis B_Homo sapiens_hsa05161	0.63757230
84	Tuberculosis_Homo sapiens_hsa05152	0.62778242
85	Lysine degradation_Homo sapiens_hsa00310	0.62772037
86	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.59276901
87	Small cell lung cancer_Homo sapiens_hsa05222	0.59230427
88	Choline metabolism in cancer_Homo sapiens_hsa05231	0.58008525
89	TNF signaling pathway_Homo sapiens_hsa04668	0.56569163
90	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.55452817
91	Pertussis_Homo sapiens_hsa05133	0.53142764
92	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.52916239
93	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.52773731
94	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.52099873
95	Type II diabetes mellitus_Homo sapiens_hsa04930	0.48520073
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46077086
97	FoxO signaling pathway_Homo sapiens_hsa04068	0.45887195
98	Fatty acid degradation_Homo sapiens_hsa00071	0.45792984
99	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.45697107
100	Shigellosis_Homo sapiens_hsa05131	0.45464570

C6ORF106

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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