Rank | Gene Set | Z-score |
---|---|---|
1 | protein localization to endosome (GO:0036010) | 4.23796692 |
2 | regulation of early endosome to late endosome transport (GO:2000641) | 3.87526594 |
3 | NADH metabolic process (GO:0006734) | 3.65754278 |
4 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.55823310 |
5 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.54303874 |
6 | regulation of cholesterol homeostasis (GO:2000188) | 3.47304200 |
7 | focal adhesion assembly (GO:0048041) | 3.42338152 |
8 | cell-substrate adherens junction assembly (GO:0007045) | 3.42338152 |
9 | adherens junction assembly (GO:0034333) | 3.34377201 |
10 | COPI coating of Golgi vesicle (GO:0048205) | 3.20820338 |
11 | Golgi transport vesicle coating (GO:0048200) | 3.20820338 |
12 | creatine metabolic process (GO:0006600) | 3.20396328 |
13 | urea cycle (GO:0000050) | 3.07093426 |
14 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 3.04591630 |
15 | urea metabolic process (GO:0019627) | 3.03168370 |
16 | stress fiber assembly (GO:0043149) | 3.00466551 |
17 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 2.91883087 |
18 | pinocytosis (GO:0006907) | 2.90337381 |
19 | nitrogen cycle metabolic process (GO:0071941) | 2.85747007 |
20 | cell-substrate junction assembly (GO:0007044) | 2.83036871 |
21 | embryonic process involved in female pregnancy (GO:0060136) | 2.82126819 |
22 | dicarboxylic acid biosynthetic process (GO:0043650) | 2.81680028 |
23 | oxaloacetate metabolic process (GO:0006107) | 2.80591640 |
24 | 3-UTR-mediated mRNA stabilization (GO:0070935) | 2.79088365 |
25 | mannose metabolic process (GO:0006013) | 2.78067014 |
26 | low-density lipoprotein particle clearance (GO:0034383) | 2.77906397 |
27 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 2.76877233 |
28 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 2.75438283 |
29 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 2.72108100 |
30 | positive regulation of myotube differentiation (GO:0010831) | 2.71617377 |
31 | cellular protein complex localization (GO:0034629) | 2.70077263 |
32 | barbed-end actin filament capping (GO:0051016) | 2.67491574 |
33 | fructose metabolic process (GO:0006000) | 2.65701584 |
34 | activation of MAPKKK activity (GO:0000185) | 2.62420074 |
35 | muscle filament sliding (GO:0030049) | 2.59846874 |
36 | actin-myosin filament sliding (GO:0033275) | 2.59846874 |
37 | cellular response to thyroid hormone stimulus (GO:0097067) | 2.57460605 |
38 | negative regulation of fibrinolysis (GO:0051918) | 2.56722531 |
39 | response to thyroid hormone (GO:0097066) | 2.53878351 |
40 | apoptotic process involved in morphogenesis (GO:0060561) | 2.52616542 |
41 | response to laminar fluid shear stress (GO:0034616) | 2.50957930 |
42 | epithelial cell-cell adhesion (GO:0090136) | 2.50546422 |
43 | activation of signaling protein activity involved in unfolded protein response (GO:0006987) | 2.50371869 |
44 | protein-lipid complex assembly (GO:0065005) | 2.49614591 |
45 | modulation by symbiont of host cellular process (GO:0044068) | 2.48952211 |
46 | tricarboxylic acid metabolic process (GO:0072350) | 2.47514045 |
47 | negative regulation of cell size (GO:0045792) | 2.47055387 |
48 | positive regulation of Cdc42 GTPase activity (GO:0043089) | 2.45601153 |
49 | activation of Rac GTPase activity (GO:0032863) | 2.44431299 |
50 | skeletal muscle contraction (GO:0003009) | 2.43367888 |
51 | endoplasmic reticulum calcium ion homeostasis (GO:0032469) | 2.42737499 |
52 | regulation of fatty acid biosynthetic process (GO:0042304) | 2.42534210 |
53 | gluconeogenesis (GO:0006094) | 2.41808268 |
54 | regulation of ARF protein signal transduction (GO:0032012) | 2.41547646 |
55 | positive regulation of extracellular matrix organization (GO:1903055) | 2.38759571 |
56 | positive regulation of nuclease activity (GO:0032075) | 2.38409618 |
57 | sodium ion export (GO:0071436) | 2.37496988 |
58 | maternal placenta development (GO:0001893) | 2.37348994 |
59 | negative regulation of protein localization to plasma membrane (GO:1903077) | 2.35638603 |
60 | positive regulation of cellular amide metabolic process (GO:0034250) | 2.35456990 |
61 | negative regulation of necroptotic process (GO:0060546) | 2.34873746 |
62 | regulation of cholesterol biosynthetic process (GO:0045540) | 2.34816493 |
63 | negative regulation of toll-like receptor 4 signaling pathway (GO:0034144) | 2.34456338 |
64 | pentose-phosphate shunt (GO:0006098) | 2.33983309 |
65 | regulation of histone H3-K27 methylation (GO:0061085) | 2.33895286 |
66 | desmosome organization (GO:0002934) | 2.33818101 |
67 | epithelial cell differentiation involved in prostate gland development (GO:0060742) | 2.33336176 |
68 | response to mercury ion (GO:0046689) | 2.32543792 |
69 | hypotonic response (GO:0006971) | 2.30874656 |
70 | positive regulation of receptor recycling (GO:0001921) | 2.30695638 |
71 | hexose biosynthetic process (GO:0019319) | 2.30404222 |
72 | monosaccharide biosynthetic process (GO:0046364) | 2.30272513 |
73 | regulation of glucose import in response to insulin stimulus (GO:2001273) | 2.29050972 |
74 | regulation of cholesterol storage (GO:0010885) | 2.28954519 |
75 | negative regulation of lipid transport (GO:0032369) | 2.28874874 |
76 | surfactant homeostasis (GO:0043129) | 2.28753837 |
77 | glucose 6-phosphate metabolic process (GO:0051156) | 2.25789895 |
78 | cortical actin cytoskeleton organization (GO:0030866) | 2.23154134 |
79 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059) | 2.23110751 |
80 | skin morphogenesis (GO:0043589) | 2.22973115 |
81 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 2.22750723 |
82 | basement membrane organization (GO:0071711) | 2.22040304 |
83 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.21364500 |
84 | positive regulation of Rap GTPase activity (GO:0032854) | 2.21187145 |
85 | glycogen catabolic process (GO:0005980) | 2.20363016 |
86 | very-low-density lipoprotein particle assembly (GO:0034379) | 2.19441901 |
87 | regulation of extracellular matrix disassembly (GO:0010715) | 2.18970104 |
88 | ER-nucleus signaling pathway (GO:0006984) | 2.18538372 |
89 | endoplasmic reticulum unfolded protein response (GO:0030968) | 2.17506879 |
90 | regulation of fibrinolysis (GO:0051917) | 2.17386042 |
91 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.17160805 |
92 | regulation of nuclease activity (GO:0032069) | 2.17136893 |
93 | protein complex localization (GO:0031503) | 2.16381773 |
94 | striated muscle contraction (GO:0006941) | 2.15854737 |
95 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 2.15575719 |
96 | positive regulation of protein dephosphorylation (GO:0035307) | 2.15555576 |
97 | peptidyl-threonine phosphorylation (GO:0018107) | 2.15123461 |
98 | fatty acid homeostasis (GO:0055089) | 2.14566922 |
99 | regulation of necroptotic process (GO:0060544) | 2.13010845 |
100 | cellular hyperosmotic response (GO:0071474) | 2.12896318 |
Rank | Gene Set | Z-score |
---|---|---|
1 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 3.44370522 |
2 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 2.75974718 |
3 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.58486830 |
4 | MYC_22102868_ChIP-Seq_BL_Human | 2.57008569 |
5 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.49406938 |
6 | LXR_22292898_ChIP-Seq_THP-1_Human | 2.40707505 |
7 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.35038158 |
8 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.30230553 |
9 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.24905748 |
10 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.21106222 |
11 | TCF7_22412390_ChIP-Seq_EML_Mouse | 2.16193682 |
12 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 2.15679699 |
13 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.15081659 |
14 | CLOCK_20551151_ChIP-Seq_293T_Human | 2.14887629 |
15 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 2.05092069 |
16 | RACK7_27058665_Chip-Seq_MCF-7_Human | 2.04268685 |
17 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.02431114 |
18 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.92684720 |
19 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.92384898 |
20 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.88382125 |
21 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.87523780 |
22 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.84647052 |
23 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.76689229 |
24 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.75567088 |
25 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.74317602 |
26 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.72499506 |
27 | KDM2B_26808549_Chip-Seq_K562_Human | 1.70445350 |
28 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.65583061 |
29 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.62640505 |
30 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.55655074 |
31 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.51694852 |
32 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.50691335 |
33 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.49750408 |
34 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.49563216 |
35 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.48208429 |
36 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.46447171 |
37 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.43214172 |
38 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.40927370 |
39 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.39503242 |
40 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.39453937 |
41 | MAF_26560356_Chip-Seq_TH1_Human | 1.39233795 |
42 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.37292803 |
43 | GATA1_19941826_ChIP-Seq_K562_Human | 1.36544281 |
44 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.34982477 |
45 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.34920485 |
46 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.34442749 |
47 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.33665661 |
48 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.33665661 |
49 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.33191361 |
50 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.32951697 |
51 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.31351358 |
52 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.31333507 |
53 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.31102287 |
54 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.30366465 |
55 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.30095180 |
56 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.29431166 |
57 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.26345147 |
58 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.26240956 |
59 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.26114021 |
60 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.25284230 |
61 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.25217409 |
62 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.24435660 |
63 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.23790484 |
64 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.23660298 |
65 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.22078987 |
66 | ATF3_27146783_Chip-Seq_COLON_Human | 1.21578970 |
67 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.20673725 |
68 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.19589877 |
69 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.19038951 |
70 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.18809719 |
71 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.17947621 |
72 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.17391253 |
73 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.15554758 |
74 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.13198291 |
75 | SPI1_23127762_ChIP-Seq_K562_Human | 1.12534499 |
76 | GATA1_22025678_ChIP-Seq_K562_Human | 1.12211437 |
77 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.11565695 |
78 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 1.11447994 |
79 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.10614241 |
80 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.10467875 |
81 | P68_20966046_ChIP-Seq_HELA_Human | 1.09561502 |
82 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.08239322 |
83 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.08047963 |
84 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.07273688 |
85 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.05946459 |
86 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.05767864 |
87 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.04786198 |
88 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.04189436 |
89 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.04150608 |
90 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.04017198 |
91 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.03068083 |
92 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.99597505 |
93 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.99532243 |
94 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.99160252 |
95 | MAF_26560356_Chip-Seq_TH2_Human | 0.98024152 |
96 | UTX_26944678_Chip-Seq_JUKART_Human | 0.97669530 |
97 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.96705459 |
98 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.96511901 |
99 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.96206286 |
100 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.95601476 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005451_abnormal_body_composition | 4.41123362 |
2 | MP0003705_abnormal_hypodermis_morpholog | 3.56145294 |
3 | MP0009840_abnormal_foam_cell | 3.14078067 |
4 | MP0010234_abnormal_vibrissa_follicle | 2.97198181 |
5 | MP0003191_abnormal_cellular_cholesterol | 2.75127797 |
6 | MP0005058_abnormal_lysosome_morphology | 2.63534389 |
7 | MP0004233_abnormal_muscle_weight | 2.58639021 |
8 | MP0002139_abnormal_hepatobiliary_system | 2.54680034 |
9 | MP0000751_myopathy | 2.47037911 |
10 | MP0003566_abnormal_cell_adhesion | 2.34491475 |
11 | MP0002877_abnormal_melanocyte_morpholog | 2.10306565 |
12 | MP0008260_abnormal_autophagy | 1.98788413 |
13 | MP0004185_abnormal_adipocyte_glucose | 1.93942408 |
14 | MP0003303_peritoneal_inflammation | 1.93801792 |
15 | MP0005076_abnormal_cell_differentiation | 1.93767077 |
16 | MP0000747_muscle_weakness | 1.89545378 |
17 | MP0003453_abnormal_keratinocyte_physiol | 1.85386598 |
18 | MP0004510_myositis | 1.81327402 |
19 | MP0004087_abnormal_muscle_fiber | 1.79962465 |
20 | MP0005666_abnormal_adipose_tissue | 1.76781473 |
21 | MP0004036_abnormal_muscle_relaxation | 1.72046392 |
22 | MP0002796_impaired_skin_barrier | 1.70969550 |
23 | MP0003646_muscle_fatigue | 1.69951477 |
24 | MP0003300_gastrointestinal_ulcer | 1.69890150 |
25 | MP0003091_abnormal_cell_migration | 1.69748885 |
26 | MP0000749_muscle_degeneration | 1.66902190 |
27 | MP0005409_darkened_coat_color | 1.59471960 |
28 | MP0003656_abnormal_erythrocyte_physiolo | 1.59377695 |
29 | MP0000759_abnormal_skeletal_muscle | 1.57635526 |
30 | MP0005375_adipose_tissue_phenotype | 1.54860263 |
31 | MP0005257_abnormal_intraocular_pressure | 1.48320311 |
32 | MP0002269_muscular_atrophy | 1.41439167 |
33 | MP0000003_abnormal_adipose_tissue | 1.38900388 |
34 | MP0010630_abnormal_cardiac_muscle | 1.38652125 |
35 | MP0003172_abnormal_lysosome_physiology | 1.38241659 |
36 | MP0008438_abnormal_cutaneous_collagen | 1.35682056 |
37 | MP0004947_skin_inflammation | 1.33998987 |
38 | MP0005330_cardiomyopathy | 1.32690414 |
39 | MP0000733_abnormal_muscle_development | 1.30799593 |
40 | MP0003329_amyloid_beta_deposits | 1.30322283 |
41 | MP0001348_abnormal_lacrimal_gland | 1.29854788 |
42 | MP0004130_abnormal_muscle_cell | 1.27785922 |
43 | MP0002971_abnormal_brown_adipose | 1.26951195 |
44 | MP0010352_gastrointestinal_tract_polyps | 1.24291096 |
45 | MP0001849_ear_inflammation | 1.22425216 |
46 | MP0002106_abnormal_muscle_physiology | 1.21438083 |
47 | MP0005670_abnormal_white_adipose | 1.18312485 |
48 | MP0003075_altered_response_to | 1.15263672 |
49 | MP0005464_abnormal_platelet_physiology | 1.14996484 |
50 | MP0006138_congestive_heart_failure | 1.14669767 |
51 | MP0004084_abnormal_cardiac_muscle | 1.13760279 |
52 | MP0004264_abnormal_extraembryonic_tissu | 1.12897743 |
53 | MP0000750_abnormal_muscle_regeneration | 1.10885602 |
54 | MP0003436_decreased_susceptibility_to | 1.10445618 |
55 | MP0000858_altered_metastatic_potential | 1.09672674 |
56 | MP0005023_abnormal_wound_healing | 1.08629852 |
57 | MP0002332_abnormal_exercise_endurance | 1.06656157 |
58 | MP0009672_abnormal_birth_weight | 1.03813694 |
59 | MP0005365_abnormal_bile_salt | 1.02137910 |
60 | MP0009780_abnormal_chondrocyte_physiolo | 1.01712378 |
61 | MP0000604_amyloidosis | 1.01674963 |
62 | MP0001661_extended_life_span | 1.00339141 |
63 | MP0004858_abnormal_nervous_system | 0.99677330 |
64 | MP0003828_pulmonary_edema | 0.98222915 |
65 | MP0005501_abnormal_skin_physiology | 0.97854742 |
66 | MP0002998_abnormal_bone_remodeling | 0.96840852 |
67 | MP0008874_decreased_physiological_sensi | 0.95845722 |
68 | MP0001915_intracranial_hemorrhage | 0.94203639 |
69 | MP0000609_abnormal_liver_physiology | 0.91970117 |
70 | MP0003690_abnormal_glial_cell | 0.91358481 |
71 | MP0003221_abnormal_cardiomyocyte_apopto | 0.91202727 |
72 | MP0005369_muscle_phenotype | 0.91120587 |
73 | MP0003045_fibrosis | 0.89920713 |
74 | MP0003950_abnormal_plasma_membrane | 0.89815382 |
75 | MP0004272_abnormal_basement_membrane | 0.87651486 |
76 | MP0009115_abnormal_fat_cell | 0.86064141 |
77 | MP0005166_decreased_susceptibility_to | 0.85966532 |
78 | MP0002089_abnormal_postnatal_growth/wei | 0.85407019 |
79 | MP0009333_abnormal_splenocyte_physiolog | 0.85362318 |
80 | MP0000685_abnormal_immune_system | 0.85111272 |
81 | MP0000678_abnormal_parathyroid_gland | 0.84405166 |
82 | MP0005621_abnormal_cell_physiology | 0.82532298 |
83 | MP0002972_abnormal_cardiac_muscle | 0.82335341 |
84 | MP0001730_embryonic_growth_arrest | 0.81585031 |
85 | MP0003868_abnormal_feces_composition | 0.78811604 |
86 | MP0002060_abnormal_skin_morphology | 0.76663718 |
87 | MP0003879_abnormal_hair_cell | 0.76440530 |
88 | MP0003763_abnormal_thymus_physiology | 0.75041975 |
89 | MP0005165_increased_susceptibility_to | 0.73556932 |
90 | MP0005275_abnormal_skin_tensile | 0.72732996 |
91 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.72043679 |
92 | MP0001851_eye_inflammation | 0.70404584 |
93 | MP0002166_altered_tumor_susceptibility | 0.70114850 |
94 | MP0004145_abnormal_muscle_electrophysio | 0.70090397 |
95 | MP0010329_abnormal_lipoprotein_level | 0.69828056 |
96 | MP0003183_abnormal_peptide_metabolism | 0.69695794 |
97 | MP0001853_heart_inflammation | 0.68176256 |
98 | MP0000767_abnormal_smooth_muscle | 0.67849933 |
99 | MP0001216_abnormal_epidermal_layer | 0.67638619 |
100 | MP0002118_abnormal_lipid_homeostasis | 0.65636059 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Exercise-induced myalgia (HP:0003738) | 4.16869602 |
2 | Muscle fiber inclusion bodies (HP:0100299) | 3.74314253 |
3 | Nemaline bodies (HP:0003798) | 3.71350215 |
4 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 3.66469010 |
5 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 3.58126936 |
6 | Increased connective tissue (HP:0009025) | 3.35933124 |
7 | Type 1 muscle fiber predominance (HP:0003803) | 3.27497630 |
8 | Distal lower limb muscle weakness (HP:0009053) | 3.21779794 |
9 | Deep venous thrombosis (HP:0002625) | 2.95468013 |
10 | Myopathic facies (HP:0002058) | 2.95066170 |
11 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.83767319 |
12 | Distal lower limb amyotrophy (HP:0008944) | 2.82984308 |
13 | Hyporeflexia of lower limbs (HP:0002600) | 2.81714582 |
14 | Increased variability in muscle fiber diameter (HP:0003557) | 2.65442893 |
15 | Dysmetric saccades (HP:0000641) | 2.64783054 |
16 | Asymmetric septal hypertrophy (HP:0001670) | 2.64587224 |
17 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 2.57823054 |
18 | Rhabdomyolysis (HP:0003201) | 2.56701084 |
19 | Cholecystitis (HP:0001082) | 2.50190167 |
20 | Abnormal gallbladder physiology (HP:0012438) | 2.50190167 |
21 | EMG: myopathic abnormalities (HP:0003458) | 2.47519602 |
22 | Abnormality of the Achilles tendon (HP:0005109) | 2.41968404 |
23 | Exercise-induced muscle cramps (HP:0003710) | 2.41406197 |
24 | Achilles tendon contracture (HP:0001771) | 2.40057506 |
25 | Muscle fiber splitting (HP:0003555) | 2.32032544 |
26 | Difficulty running (HP:0009046) | 2.21307139 |
27 | Round ear (HP:0100830) | 2.18510048 |
28 | Subaortic stenosis (HP:0001682) | 2.15473539 |
29 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.15473539 |
30 | Vertebral compression fractures (HP:0002953) | 2.13425548 |
31 | Lower limb amyotrophy (HP:0007210) | 2.13033927 |
32 | Myoglobinuria (HP:0002913) | 2.11370325 |
33 | Obstructive sleep apnea (HP:0002870) | 2.09376628 |
34 | Ulnar deviation of the wrist (HP:0003049) | 2.09108297 |
35 | Muscle stiffness (HP:0003552) | 2.06100937 |
36 | Bundle branch block (HP:0011710) | 2.03851218 |
37 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.03331607 |
38 | Abnormality of complement system (HP:0005339) | 2.02197276 |
39 | Cerebral aneurysm (HP:0004944) | 2.01847031 |
40 | Fatigue (HP:0012378) | 2.00317634 |
41 | Polycythemia (HP:0001901) | 1.99518721 |
42 | Cerebral inclusion bodies (HP:0100314) | 1.98362169 |
43 | Protrusio acetabuli (HP:0003179) | 1.97231664 |
44 | Sudden death (HP:0001699) | 1.96961872 |
45 | Systemic lupus erythematosus (HP:0002725) | 1.95764406 |
46 | Hemorrhage of the eye (HP:0011885) | 1.95261960 |
47 | Myocardial infarction (HP:0001658) | 1.94577726 |
48 | Ankyloglossia (HP:0010296) | 1.94094323 |
49 | Foot dorsiflexor weakness (HP:0009027) | 1.92987564 |
50 | Reticulocytosis (HP:0001923) | 1.91323659 |
51 | Ventricular tachycardia (HP:0004756) | 1.91252821 |
52 | Neck muscle weakness (HP:0000467) | 1.90792705 |
53 | Spinal rigidity (HP:0003306) | 1.90577725 |
54 | Flat acetabular roof (HP:0003180) | 1.88823360 |
55 | Xanthomatosis (HP:0000991) | 1.87502545 |
56 | Gastrointestinal stroma tumor (HP:0100723) | 1.85306177 |
57 | Complement deficiency (HP:0004431) | 1.85131470 |
58 | Right ventricular cardiomyopathy (HP:0011663) | 1.84367385 |
59 | Cholelithiasis (HP:0001081) | 1.84054936 |
60 | Advanced eruption of teeth (HP:0006288) | 1.82891932 |
61 | Eczematoid dermatitis (HP:0000976) | 1.81785215 |
62 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.81718564 |
63 | Osteolytic defects of the hand bones (HP:0009699) | 1.81718564 |
64 | Upper limb amyotrophy (HP:0009129) | 1.81246681 |
65 | Distal upper limb amyotrophy (HP:0007149) | 1.81246681 |
66 | Abnormality of the fingertips (HP:0001211) | 1.80755813 |
67 | Ragged-red muscle fibers (HP:0003200) | 1.80680041 |
68 | Hyperacusis (HP:0010780) | 1.78500690 |
69 | Segmental peripheral demyelination/remyelination (HP:0003481) | 1.74392373 |
70 | Abnormality of the foot musculature (HP:0001436) | 1.74160156 |
71 | Progressive external ophthalmoplegia (HP:0000590) | 1.73312243 |
72 | Distal arthrogryposis (HP:0005684) | 1.72955954 |
73 | Progressive muscle weakness (HP:0003323) | 1.71490415 |
74 | Bulbar palsy (HP:0001283) | 1.71464462 |
75 | Neurofibrillary tangles (HP:0002185) | 1.70980950 |
76 | Abnormality of the salivary glands (HP:0010286) | 1.68598157 |
77 | Axonal loss (HP:0003447) | 1.68297347 |
78 | Dysostosis multiplex (HP:0000943) | 1.66746440 |
79 | Difficulty climbing stairs (HP:0003551) | 1.65681167 |
80 | Abnormal atrioventricular conduction (HP:0005150) | 1.63537101 |
81 | Abnormality of the common coagulation pathway (HP:0010990) | 1.63485200 |
82 | Cellulitis (HP:0100658) | 1.63231241 |
83 | Atrioventricular block (HP:0001678) | 1.62283166 |
84 | Glomerulonephritis (HP:0000099) | 1.61785324 |
85 | Decreased motor nerve conduction velocity (HP:0003431) | 1.61285177 |
86 | Hypercholesterolemia (HP:0003124) | 1.60002693 |
87 | Abnormality of glycolipid metabolism (HP:0010969) | 1.59815635 |
88 | Abnormality of liposaccharide metabolism (HP:0010968) | 1.59815635 |
89 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 1.59815635 |
90 | Premature rupture of membranes (HP:0001788) | 1.59516293 |
91 | Slow saccadic eye movements (HP:0000514) | 1.58745504 |
92 | Aneurysm (HP:0002617) | 1.58738989 |
93 | Back pain (HP:0003418) | 1.57706492 |
94 | Abnormal gallbladder morphology (HP:0012437) | 1.57345695 |
95 | Colitis (HP:0002583) | 1.57229372 |
96 | Bowel incontinence (HP:0002607) | 1.56927850 |
97 | Frequent falls (HP:0002359) | 1.55692791 |
98 | Emphysema (HP:0002097) | 1.53512485 |
99 | Supranuclear gaze palsy (HP:0000605) | 1.53499214 |
100 | Mucopolysacchariduria (HP:0008155) | 1.53157850 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PRPF4B | 3.96694265 |
2 | TRIB3 | 3.53866855 |
3 | EEF2K | 3.22818922 |
4 | TTN | 2.73060948 |
5 | RIPK1 | 2.61287721 |
6 | SMG1 | 2.46462817 |
7 | KSR2 | 2.43717379 |
8 | ICK | 2.41468943 |
9 | IRAK3 | 2.29346798 |
10 | ERN1 | 2.24271049 |
11 | CDK12 | 2.08812536 |
12 | FGFR4 | 2.08502914 |
13 | RIPK4 | 1.95176216 |
14 | MAP3K13 | 1.83872115 |
15 | SIK1 | 1.72252297 |
16 | MAP2K3 | 1.69446362 |
17 | OBSCN | 1.67508139 |
18 | LATS2 | 1.64526508 |
19 | MAP3K9 | 1.56077649 |
20 | MAP3K2 | 1.49078939 |
21 | MAP3K3 | 1.48143751 |
22 | ARAF | 1.45582910 |
23 | TAOK2 | 1.34188495 |
24 | MAP3K1 | 1.33066239 |
25 | PDGFRA | 1.24766727 |
26 | PDPK1 | 1.23847119 |
27 | PHKG1 | 1.22783539 |
28 | PHKG2 | 1.22783539 |
29 | MAPK12 | 1.10925794 |
30 | STK24 | 1.10154115 |
31 | MAP3K10 | 1.09984849 |
32 | MAPK11 | 1.06016859 |
33 | FGFR3 | 1.05501599 |
34 | DMPK | 0.97237451 |
35 | NME2 | 0.96634061 |
36 | TYK2 | 0.96354542 |
37 | BMX | 0.95304117 |
38 | CDC42BPA | 0.89192587 |
39 | LMTK2 | 0.88832369 |
40 | MAP3K14 | 0.88223323 |
41 | MTOR | 0.88081459 |
42 | SGK3 | 0.87943734 |
43 | EPHA2 | 0.85893385 |
44 | PDK1 | 0.85566776 |
45 | MAP3K8 | 0.84520393 |
46 | TESK1 | 0.83983275 |
47 | SCYL2 | 0.81050319 |
48 | MARK2 | 0.80691579 |
49 | RAF1 | 0.78662770 |
50 | KSR1 | 0.77695611 |
51 | TAOK1 | 0.76385446 |
52 | MST1R | 0.75126515 |
53 | PAK4 | 0.74338120 |
54 | BRAF | 0.73641399 |
55 | JAK3 | 0.73272665 |
56 | TRPM7 | 0.72621568 |
57 | EPHB1 | 0.72259714 |
58 | NEK9 | 0.70826862 |
59 | TBK1 | 0.70666496 |
60 | JAK1 | 0.69021638 |
61 | ZAP70 | 0.67128010 |
62 | STK38 | 0.65948313 |
63 | WNK1 | 0.65905396 |
64 | IRAK2 | 0.65363464 |
65 | PKN2 | 0.63990519 |
66 | MAP4K1 | 0.63470243 |
67 | MOS | 0.60785926 |
68 | PTK6 | 0.60752724 |
69 | RET | 0.59424049 |
70 | MAP3K11 | 0.59147455 |
71 | RPS6KA2 | 0.58691594 |
72 | DDR2 | 0.57967350 |
73 | MAPKAPK3 | 0.57232609 |
74 | MAP3K7 | 0.55020276 |
75 | MAP2K1 | 0.54958630 |
76 | MAP3K6 | 0.54825842 |
77 | PTK2 | 0.54091998 |
78 | ALK | 0.53705180 |
79 | CDK6 | 0.52573796 |
80 | RPS6KC1 | 0.51113355 |
81 | RPS6KL1 | 0.51113355 |
82 | PRKG2 | 0.50233645 |
83 | CDK4 | 0.49935402 |
84 | SIK3 | 0.49539298 |
85 | CAMK1D | 0.49441172 |
86 | RPS6KB2 | 0.47750197 |
87 | PRKD2 | 0.46882732 |
88 | LRRK2 | 0.46266878 |
89 | PRKAA2 | 0.46136934 |
90 | HIPK2 | 0.45794576 |
91 | AKT2 | 0.45685402 |
92 | IRAK4 | 0.45536838 |
93 | JAK2 | 0.43711952 |
94 | TYRO3 | 0.43059319 |
95 | PRKD3 | 0.42871085 |
96 | MAPK10 | 0.39576989 |
97 | CAMK4 | 0.37637431 |
98 | MAPK7 | 0.37615473 |
99 | MELK | 0.31288713 |
100 | CSK | 0.30543667 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.74235300 |
2 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.54446375 |
3 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.16974621 |
4 | Other glycan degradation_Homo sapiens_hsa00511 | 2.09415272 |
5 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.03561545 |
6 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.71467032 |
7 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.70818277 |
8 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.64530682 |
9 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.59450956 |
10 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.58860123 |
11 | Prion diseases_Homo sapiens_hsa05020 | 1.53787254 |
12 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.53533796 |
13 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.43247388 |
14 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.41811392 |
15 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.39692149 |
16 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.35860852 |
17 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.34683100 |
18 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.30068715 |
19 | Carbon metabolism_Homo sapiens_hsa01200 | 1.29939650 |
20 | Long-term potentiation_Homo sapiens_hsa04720 | 1.29760727 |
21 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.28826862 |
22 | Thyroid cancer_Homo sapiens_hsa05216 | 1.20351995 |
23 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.17032701 |
24 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.16099955 |
25 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.14204602 |
26 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.13965472 |
27 | Insulin resistance_Homo sapiens_hsa04931 | 1.13587296 |
28 | AMPK signaling pathway_Homo sapiens_hsa04152 | 1.13553691 |
29 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.13507506 |
30 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.11536265 |
31 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.10868971 |
32 | Glioma_Homo sapiens_hsa05214 | 1.10034829 |
33 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.09143551 |
34 | Endometrial cancer_Homo sapiens_hsa05213 | 1.07755890 |
35 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.03673887 |
36 | Bladder cancer_Homo sapiens_hsa05219 | 1.03217164 |
37 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.01012172 |
38 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.00870517 |
39 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.98346435 |
40 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.96655614 |
41 | Galactose metabolism_Homo sapiens_hsa00052 | 0.95010955 |
42 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.94191947 |
43 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.92510026 |
44 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.92441291 |
45 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.92354970 |
46 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.91195795 |
47 | Focal adhesion_Homo sapiens_hsa04510 | 0.89405805 |
48 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.87822844 |
49 | Amoebiasis_Homo sapiens_hsa05146 | 0.87573275 |
50 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.86862254 |
51 | Hepatitis C_Homo sapiens_hsa05160 | 0.86227759 |
52 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.85368184 |
53 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.84564681 |
54 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.84101586 |
55 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.82757302 |
56 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.81811564 |
57 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.81153286 |
58 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.80819680 |
59 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.79761273 |
60 | Bile secretion_Homo sapiens_hsa04976 | 0.78957193 |
61 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.78814819 |
62 | Adherens junction_Homo sapiens_hsa04520 | 0.78267049 |
63 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.77884963 |
64 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.75939688 |
65 | Influenza A_Homo sapiens_hsa05164 | 0.75721345 |
66 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.75586426 |
67 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.75247377 |
68 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.74699755 |
69 | Leishmaniasis_Homo sapiens_hsa05140 | 0.74304914 |
70 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.73499920 |
71 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.73401835 |
72 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.73356997 |
73 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.72093093 |
74 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.71507292 |
75 | Lysosome_Homo sapiens_hsa04142 | 0.70977857 |
76 | Viral myocarditis_Homo sapiens_hsa05416 | 0.69912867 |
77 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.69801964 |
78 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.66042694 |
79 | Apoptosis_Homo sapiens_hsa04210 | 0.65941924 |
80 | Endocytosis_Homo sapiens_hsa04144 | 0.65404615 |
81 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.64621482 |
82 | Prostate cancer_Homo sapiens_hsa05215 | 0.64168515 |
83 | Hepatitis B_Homo sapiens_hsa05161 | 0.63757230 |
84 | Tuberculosis_Homo sapiens_hsa05152 | 0.62778242 |
85 | Lysine degradation_Homo sapiens_hsa00310 | 0.62772037 |
86 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.59276901 |
87 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.59230427 |
88 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.58008525 |
89 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.56569163 |
90 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.55452817 |
91 | Pertussis_Homo sapiens_hsa05133 | 0.53142764 |
92 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.52916239 |
93 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.52773731 |
94 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.52099873 |
95 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.48520073 |
96 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.46077086 |
97 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.45887195 |
98 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.45792984 |
99 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.45697107 |
100 | Shigellosis_Homo sapiens_hsa05131 | 0.45464570 |