ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axoneme assembly (GO:0035082)	9.28829138
2	left/right pattern formation (GO:0060972)	7.82888811
3	intraciliary transport (GO:0042073)	7.71427694
4	regulation of cilium movement (GO:0003352)	7.26593960
5	cilium organization (GO:0044782)	6.67769752
6	cilium assembly (GO:0042384)	6.51929181
7	ventricular system development (GO:0021591)	6.40115590
8	left/right axis specification (GO:0070986)	6.01346253
9	microtubule bundle formation (GO:0001578)	5.61674193
10	cilium morphogenesis (GO:0060271)	5.47972525
11	protein localization to cilium (GO:0061512)	5.17296490
12	cellular component assembly involved in morphogenesis (GO:0010927)	5.06686160
13	microtubule-based movement (GO:0007018)	4.49965429
14	centriole assembly (GO:0098534)	4.47217751
15	regulation of microtubule-based movement (GO:0060632)	4.42527849
16	cell projection assembly (GO:0030031)	4.37306915
17	microtubule depolymerization (GO:0007019)	4.24187473
18	smoothened signaling pathway (GO:0007224)	4.19745920
19	nonmotile primary cilium assembly (GO:0035058)	4.12980964
20	centriole replication (GO:0007099)	4.05563632
21	primary alcohol catabolic process (GO:0034310)	3.85695257
22	determination of left/right symmetry (GO:0007368)	3.80757758
23	nucleoside diphosphate phosphorylation (GO:0006165)	3.80107428
24	determination of bilateral symmetry (GO:0009855)	3.74225184
25	lateral sprouting from an epithelium (GO:0060601)	3.70764548
26	specification of symmetry (GO:0009799)	3.65031788
27	microtubule polymerization or depolymerization (GO:0031109)	3.56971513
28	establishment of planar polarity (GO:0001736)	3.55506973
29	establishment of tissue polarity (GO:0007164)	3.55506973
30	vitamin transmembrane transport (GO:0035461)	3.30637232
31	lateral ventricle development (GO:0021670)	3.30069374
32	retinal rod cell development (GO:0046548)	3.25537660
33	lung epithelium development (GO:0060428)	3.16684205
34	response to xenobiotic stimulus (GO:0009410)	3.16372670
35	ethanol metabolic process (GO:0006067)	3.08769308
36	limb development (GO:0060173)	3.08024660
37	appendage development (GO:0048736)	3.08024660
38	sperm motility (GO:0030317)	3.04396714
39	protein polyglutamylation (GO:0018095)	3.00973222
40	photoreceptor cell maintenance (GO:0045494)	2.99854877
41	organelle assembly (GO:0070925)	2.94376028
42	neuronal stem cell maintenance (GO:0097150)	2.91883527
43	regulation of collateral sprouting (GO:0048670)	2.90136149
44	regulation of smoothened signaling pathway (GO:0008589)	2.87188802
45	positive regulation of smoothened signaling pathway (GO:0045880)	2.86810150
46	sperm capacitation (GO:0048240)	2.84861157
47	terpenoid biosynthetic process (GO:0016114)	2.80608887
48	microtubule-based process (GO:0007017)	2.79530509
49	diterpenoid biosynthetic process (GO:0016102)	2.78351051
50	negative regulation of T cell differentiation in thymus (GO:0033085)	2.77614856
51	carnitine metabolic process (GO:0009437)	2.76226818
52	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.75734999
53	establishment or maintenance of monopolar cell polarity (GO:0061339)	2.75357533
54	establishment of monopolar cell polarity (GO:0061162)	2.75357533
55	intra-S DNA damage checkpoint (GO:0031573)	2.74682149
56	cytoplasmic microtubule organization (GO:0031122)	2.72057180
57	dorsal/ventral pattern formation (GO:0009953)	2.71548788
58	cornea development in camera-type eye (GO:0061303)	2.67946658
59	tongue development (GO:0043586)	2.67913260
60	retinal ganglion cell axon guidance (GO:0031290)	2.64100218
61	heart looping (GO:0001947)	2.63353584
62	negative regulation of B cell mediated immunity (GO:0002713)	2.63032293
63	negative regulation of immunoglobulin mediated immune response (GO:0002890)	2.63032293
64	negative regulation of humoral immune response (GO:0002921)	2.62865660
65	base-excision repair, AP site formation (GO:0006285)	2.61699913
66	neural tube formation (GO:0001841)	2.60425190
67	one-carbon compound transport (GO:0019755)	2.58620746
68	retinoic acid metabolic process (GO:0042573)	2.55171906
69	amino-acid betaine metabolic process (GO:0006577)	2.54812805
70	GTP biosynthetic process (GO:0006183)	2.53199334
71	neuron fate determination (GO:0048664)	2.52421013
72	aldehyde catabolic process (GO:0046185)	2.50514537
73	establishment of apical/basal cell polarity (GO:0035089)	2.49613262
74	dorsal/ventral neural tube patterning (GO:0021904)	2.49010749
75	neurotransmitter catabolic process (GO:0042135)	2.45794357
76	glomerular epithelial cell development (GO:0072310)	2.45528295
77	embryonic heart tube morphogenesis (GO:0003143)	2.43959216
78	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.43453191
79	pyrimidine nucleotide catabolic process (GO:0006244)	2.41539546
80	somite development (GO:0061053)	2.40383915
81	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.38564176
82	limb bud formation (GO:0060174)	2.36535939
83	spinal cord motor neuron differentiation (GO:0021522)	2.34257785
84	asymmetric protein localization (GO:0008105)	2.33883553
85	glutathione derivative metabolic process (GO:1901685)	2.32597451
86	glutathione derivative biosynthetic process (GO:1901687)	2.32597451
87	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.32095737
88	pyrimidine nucleobase catabolic process (GO:0006208)	2.31668661
89	nucleotide phosphorylation (GO:0046939)	2.30124649
90	negative regulation of inclusion body assembly (GO:0090084)	2.30106491
91	telencephalon development (GO:0021537)	2.27652125
92	ethanol oxidation (GO:0006069)	2.26812079
93	eye photoreceptor cell differentiation (GO:0001754)	2.26401598
94	photoreceptor cell differentiation (GO:0046530)	2.26401598
95	axonemal dynein complex assembly (GO:0070286)	17.2612994
96	cilium or flagellum-dependent cell motility (GO:0001539)	14.3603764
97	cilium movement (GO:0003341)	14.1080082
98	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	13.5084650
99	epithelial cilium movement (GO:0003351)	13.4585957
100	motile cilium assembly (GO:0044458)	11.8933964

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.88072206
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.34648111
3	VDR_22108803_ChIP-Seq_LS180_Human	2.78659085
4	TAF15_26573619_Chip-Seq_HEK293_Human	2.41757640
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.40432775
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.22774838
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.19963297
8	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.19344385
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.17001900
10	FUS_26573619_Chip-Seq_HEK293_Human	2.13916026
11	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.02645198
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.98656552
13	GBX2_23144817_ChIP-Seq_PC3_Human	1.96705566
14	EWS_26573619_Chip-Seq_HEK293_Human	1.95920364
15	IGF1R_20145208_ChIP-Seq_DFB_Human	1.95580671
16	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.95000175
17	DROSHA_22980978_ChIP-Seq_HELA_Human	1.92029227
18	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.90206564
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.88624252
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.87629248
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.85981115
22	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.84264640
23	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.79771220
24	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.75032259
25	P300_19829295_ChIP-Seq_ESCs_Human	1.70491416
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.70319884
27	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.70108165
28	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69475897
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.64567816
30	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.64355672
31	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.61946670
32	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.61930336
33	RNF2_27304074_Chip-Seq_NSC_Mouse	1.57826498
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.57234669
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.49811359
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44037652
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44037652
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41152986
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40485629
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.37524119
41	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.37514885
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37255569
43	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.37035332
44	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.34899291
45	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.34606257
46	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32595832
47	AR_21572438_ChIP-Seq_LNCaP_Human	1.31693952
48	STAT3_23295773_ChIP-Seq_U87_Human	1.27910067
49	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.27507076
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26951978
51	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.26188490
52	TP53_18474530_ChIP-ChIP_U2OS_Human	1.25448172
53	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.24580175
54	* TCF4_22108803_ChIP-Seq_LS180_Human	1.23794713
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.22732103
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.22732103
57	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.22069639
58	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.21577423
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.19236214
60	AHR_22903824_ChIP-Seq_MCF-7_Human	1.18363246
61	BCAT_22108803_ChIP-Seq_LS180_Human	1.15533291
62	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.15388457
63	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.14724740
64	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.14573771
65	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14054056
66	* AR_25329375_ChIP-Seq_VCAP_Human	1.13769917
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.12874448
68	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.12305870
69	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11816897
70	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.09239457
71	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.08496809
72	TCF4_23295773_ChIP-Seq_U87_Human	1.07724064
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.07165677
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07070729
75	TBL1_22424771_ChIP-Seq_293T_Human	1.06117135
76	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.05560776
77	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05375766
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04781762
79	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04457699
80	PHF8_20622853_ChIP-Seq_HELA_Human	1.03933404
81	TP53_16413492_ChIP-PET_HCT116_Human	1.03233987
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02493259
83	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.02208876
84	NFYA_21822215_ChIP-Seq_K562_Human	1.00465109
85	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.00222215
86	REST_21632747_ChIP-Seq_MESCs_Mouse	1.00024644
87	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.98826988
88	JUN_21703547_ChIP-Seq_K562_Human	0.98783205
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98014313
90	ETV1_20927104_ChIP-Seq_GIST48_Human	0.97935899
91	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.97923853
92	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.97394683
93	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.97220395
94	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.97043472
95	AR_19668381_ChIP-Seq_PC3_Human	0.96896801
96	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.95808743
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.94690316
98	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.94108259
99	NFYB_21822215_ChIP-Seq_K562_Human	0.93648350
100	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.93472668

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	5.89867314
2	MP0003136_yellow_coat_color	4.02099606
3	MP0000566_synostosis	3.82155823
4	MP0004133_heterotaxia	3.43852162
5	MP0008789_abnormal_olfactory_epithelium	3.42999282
6	MP0001984_abnormal_olfaction	3.19287011
7	MP0008875_abnormal_xenobiotic_pharmacok	3.10763551
8	MP0005394_taste/olfaction_phenotype	2.70616767
9	MP0005499_abnormal_olfactory_system	2.70616767
10	MP0010030_abnormal_orbit_morphology	2.35713449
11	MP0002282_abnormal_trachea_morphology	2.33476262
12	MP0005377_hearing/vestibular/ear_phenot	2.16752193
13	MP0003878_abnormal_ear_physiology	2.16752193
14	MP0006292_abnormal_olfactory_placode	2.15696476
15	MP0002132_abnormal_respiratory_system	2.12685827
16	MP0005248_abnormal_Harderian_gland	2.10965079
17	MP0001293_anophthalmia	1.90826300
18	MP0003122_maternal_imprinting	1.87558296
19	MP0000383_abnormal_hair_follicle	1.76996268
20	MP0000778_abnormal_nervous_system	1.76068916
21	MP0005623_abnormal_meninges_morphology	1.75627276
22	MP0002277_abnormal_respiratory_mucosa	1.65918544
23	MP0003937_abnormal_limbs/digits/tail_de	1.65409070
24	MP0002638_abnormal_pupillary_reflex	1.65238209
25	MP0000049_abnormal_middle_ear	1.64361513
26	MP0006072_abnormal_retinal_apoptosis	1.63901786
27	MP0005253_abnormal_eye_physiology	1.63366924
28	MP0000631_abnormal_neuroendocrine_gland	1.63232271
29	MP0003880_abnormal_central_pattern	1.59513123
30	MP0002233_abnormal_nose_morphology	1.57989683
31	MP0000026_abnormal_inner_ear	1.56563874
32	MP0004043_abnormal_pH_regulation	1.43357061
33	MP0005187_abnormal_penis_morphology	1.41028748
34	MP0001485_abnormal_pinna_reflex	1.39343653
35	MP0002938_white_spotting	1.37018414
36	MP0002822_catalepsy	1.36574735
37	MP0001529_abnormal_vocalization	1.35776727
38	MP0002249_abnormal_larynx_morphology	1.34008961
39	MP0002928_abnormal_bile_duct	1.30915667
40	MP0008995_early_reproductive_senescence	1.29678912
41	MP0003938_abnormal_ear_development	1.28881392
42	MP0005391_vision/eye_phenotype	1.25676029
43	MP0010678_abnormal_skin_adnexa	1.19688806
44	MP0009379_abnormal_foot_pigmentation	1.19369352
45	MP0005646_abnormal_pituitary_gland	1.18016057
46	MP0004019_abnormal_vitamin_homeostasis	1.17037049
47	MP0005551_abnormal_eye_electrophysiolog	1.12274733
48	MP0002734_abnormal_mechanical_nocicepti	1.11888704
49	MP0000955_abnormal_spinal_cord	1.11737456
50	MP0003861_abnormal_nervous_system	1.10478282
51	MP0003283_abnormal_digestive_organ	1.10158569
52	MP0002160_abnormal_reproductive_system	1.09168698
53	MP0001346_abnormal_lacrimal_gland	1.06418746
54	MP0001963_abnormal_hearing_physiology	1.05885043
55	MP0001299_abnormal_eye_distance/	1.04575719
56	MP0003121_genomic_imprinting	1.03522119
57	MP0002092_abnormal_eye_morphology	1.02186060
58	MP0006276_abnormal_autonomic_nervous	1.01575248
59	MP0005195_abnormal_posterior_eye	1.01450393
60	MP0003755_abnormal_palate_morphology	1.01084901
61	MP0002234_abnormal_pharynx_morphology	1.00796916
62	MP0001486_abnormal_startle_reflex	1.00488836
63	MP0001324_abnormal_eye_pigmentation	0.99853290
64	MP0001286_abnormal_eye_development	0.99582191
65	MP0002557_abnormal_social/conspecific_i	0.99177733
66	MP0003890_abnormal_embryonic-extraembry	0.99133199
67	MP0002102_abnormal_ear_morphology	0.98987996
68	MP0003942_abnormal_urinary_system	0.98523640
69	MP0002752_abnormal_somatic_nervous	0.97855038
70	MP0004885_abnormal_endolymph	0.97592618
71	MP0009780_abnormal_chondrocyte_physiolo	0.94268772
72	MP0000579_abnormal_nail_morphology	0.92655323
73	MP0009046_muscle_twitch	0.91628394
74	MP0002152_abnormal_brain_morphology	0.91520481
75	MP0000647_abnormal_sebaceous_gland	0.90677324
76	MP0002116_abnormal_craniofacial_bone	0.90302904
77	MP0005171_absent_coat_pigmentation	0.88412384
78	MP0003698_abnormal_male_reproductive	0.86459028
79	MP0009745_abnormal_behavioral_response	0.83619618
80	MP0005083_abnormal_biliary_tract	0.83516172
81	MP0002909_abnormal_adrenal_gland	0.81349651
82	MP0004142_abnormal_muscle_tone	0.81318347
83	MP0003787_abnormal_imprinting	0.79329144
84	MP0002168_other_aberrant_phenotype	0.78834467
85	MP0002751_abnormal_autonomic_nervous	0.78030462
86	MP0002882_abnormal_neuron_morphology	0.77994275
87	MP0001929_abnormal_gametogenesis	0.77066021
88	MP0002572_abnormal_emotion/affect_behav	0.76708630
89	MP0002697_abnormal_eye_size	0.76391270
90	MP0009053_abnormal_anal_canal	0.74538188
91	MP0002272_abnormal_nervous_system	0.74199646
92	MP0002111_abnormal_tail_morphology	0.73398551
93	MP0003119_abnormal_digestive_system	0.73136840
94	MP0001502_abnormal_circadian_rhythm	0.71950599
95	MP0005395_other_phenotype	0.69910609
96	MP0003011_delayed_dark_adaptation	0.69685769
97	MP0005389_reproductive_system_phenotype	0.69674774
98	MP0000534_abnormal_ureter_morphology	0.68299585
99	MP0002084_abnormal_developmental_patter	0.68198587
100	MP0002090_abnormal_vision	0.65733945

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory epithelium morphology (HP:0012253)	9.92840588
2	Abnormal respiratory motile cilium morphology (HP:0005938)	9.92840588
3	Abnormal respiratory motile cilium physiology (HP:0012261)	9.81850481
4	Abnormal ciliary motility (HP:0012262)	9.70968719
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	9.18278603
6	Absent/shortened dynein arms (HP:0200106)	9.18278603
7	Rhinitis (HP:0012384)	8.68824969
8	Chronic bronchitis (HP:0004469)	6.26528792
9	Bronchiectasis (HP:0002110)	6.08986362
10	Nasal polyposis (HP:0100582)	5.13760112
11	True hermaphroditism (HP:0010459)	5.13443818
12	Pancreatic fibrosis (HP:0100732)	4.84490582
13	Occipital encephalocele (HP:0002085)	4.48428762
14	Pancreatic cysts (HP:0001737)	4.16680436
15	Abnormality of midbrain morphology (HP:0002418)	4.14849676
16	Molar tooth sign on MRI (HP:0002419)	4.14849676
17	Abnormality of the nasal mucosa (HP:0000433)	4.09087831
18	Cystic liver disease (HP:0006706)	3.79810863
19	Nephronophthisis (HP:0000090)	3.75626418
20	Chronic sinusitis (HP:0011109)	3.66712630
21	Infertility (HP:0000789)	3.65777623
22	Medial flaring of the eyebrow (HP:0010747)	3.26984463
23	Postaxial foot polydactyly (HP:0001830)	3.24627036
24	Chronic hepatic failure (HP:0100626)	3.22958448
25	Recurrent sinusitis (HP:0011108)	3.17029941
26	Bronchitis (HP:0012387)	3.11198775
27	Gait imbalance (HP:0002141)	3.07687722
28	Congenital primary aphakia (HP:0007707)	3.07138759
29	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.04395154
30	Abnormality of the renal medulla (HP:0100957)	2.91034150
31	Anencephaly (HP:0002323)	2.89350466
32	Recurrent otitis media (HP:0000403)	2.82769538
33	Congenital hepatic fibrosis (HP:0002612)	2.82576557
34	Tubulointerstitial nephritis (HP:0001970)	2.76996357
35	Male infertility (HP:0003251)	2.75499961
36	Nephrogenic diabetes insipidus (HP:0009806)	2.73347445
37	Sclerocornea (HP:0000647)	2.66181683
38	Atelectasis (HP:0100750)	2.65809089
39	Postaxial hand polydactyly (HP:0001162)	2.52948596
40	Male pseudohermaphroditism (HP:0000037)	2.49020362
41	Vaginal atresia (HP:0000148)	2.29887285
42	Chronic otitis media (HP:0000389)	2.29359290
43	Genital tract atresia (HP:0001827)	2.26850800
44	Tubular atrophy (HP:0000092)	2.24488988
45	Preaxial hand polydactyly (HP:0001177)	2.22762988
46	Oculomotor apraxia (HP:0000657)	2.21906663
47	Abnormal biliary tract physiology (HP:0012439)	2.16458080
48	Bile duct proliferation (HP:0001408)	2.16458080
49	Supernumerary spleens (HP:0009799)	2.16163490
50	Poor coordination (HP:0002370)	2.13590587
51	Furrowed tongue (HP:0000221)	2.10015860
52	Median cleft lip (HP:0000161)	2.06158107
53	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.05339397
54	Asplenia (HP:0001746)	2.02166753
55	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	10.5157450
56	Broad foot (HP:0001769)	1.81851399
57	Narrow forehead (HP:0000341)	1.79171561
58	Tubulointerstitial abnormality (HP:0001969)	1.76676530
59	Aganglionic megacolon (HP:0002251)	1.65589747
60	Hyperactive renin-angiotensin system (HP:0000841)	1.61817308
61	Holoprosencephaly (HP:0001360)	1.61698175
62	Nephropathy (HP:0000112)	1.59310303
63	Abnormal drinking behavior (HP:0030082)	1.58357851
64	Polydipsia (HP:0001959)	1.58357851
65	Prominent nasal bridge (HP:0000426)	1.56398370
66	Broad distal phalanx of finger (HP:0009836)	1.56149186
67	Decreased testicular size (HP:0008734)	1.54022217
68	Aplasia/Hypoplasia of the lens (HP:0008063)	1.52405926
69	Stage 5 chronic kidney disease (HP:0003774)	1.48215184
70	Specific learning disability (HP:0001328)	1.47972783
71	Multicystic kidney dysplasia (HP:0000003)	1.45371560
72	Renal dysplasia (HP:0000110)	1.43699387
73	Anophthalmia (HP:0000528)	1.41104107
74	Retinitis pigmentosa (HP:0000510)	1.39419402
75	Chorioretinal coloboma (HP:0000567)	1.37299933
76	Absent frontal sinuses (HP:0002688)	1.37149131
77	Highly arched eyebrow (HP:0002553)	1.36973113
78	Optic nerve coloboma (HP:0000588)	1.33963076
79	Abnormality of the renal cortex (HP:0011035)	1.33490389
80	Abnormality of dentin (HP:0010299)	1.33138455
81	Septo-optic dysplasia (HP:0100842)	1.28887060
82	Bell-shaped thorax (HP:0001591)	1.28813972
83	Bifid scrotum (HP:0000048)	1.28086951
84	Dandy-Walker malformation (HP:0001305)	1.26346743
85	Decreased central vision (HP:0007663)	1.25161402
86	Abnormality of permanent molar morphology (HP:0011071)	1.24967483
87	Abnormality of the dental root (HP:0006486)	1.24967483
88	Taurodontia (HP:0000679)	1.24967483
89	Abnormality of abdominal situs (HP:0011620)	1.21276039
90	Abdominal situs inversus (HP:0003363)	1.21276039
91	Iris coloboma (HP:0000612)	1.20342884
92	Fibular hypoplasia (HP:0003038)	1.17992205
93	Tubulointerstitial fibrosis (HP:0005576)	1.17801519
94	Short foot (HP:0001773)	1.16326469
95	Micropenis (HP:0000054)	1.15986232
96	Decreased circulating renin level (HP:0003351)	1.15394313
97	Left ventricular hypertrophy (HP:0001712)	1.14629915
98	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.14422423
99	Abnormality of the middle phalanges of the toes (HP:0010183)	1.14089036
100	Depressed nasal ridge (HP:0000457)	1.13105185

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	8.80240102
2	PNCK	3.61014859
3	EPHA3	2.83847507
4	BCR	2.75778303
5	CASK	2.73293785
6	EPHA4	2.49736010
7	WEE1	2.33351921
8	MST4	2.16338948
9	MAP3K4	2.14624108
10	MAP4K2	1.92766684
11	MAP2K7	1.86034930
12	EPHA2	1.85982636
13	DYRK3	1.83854560
14	WNK3	1.59932517
15	MAPK13	1.54187818
16	TSSK6	1.49649166
17	CDK19	1.40614847
18	TRIM28	1.33156356
19	TNIK	1.32805715
20	EPHB2	1.31268531
21	CCNB1	1.31052192
22	ERBB3	1.26465462
23	MKNK1	1.25869717
24	TLK1	1.21122399
25	PRKD3	1.21084722
26	NME1	1.20249077
27	PTK2B	1.16975895
28	BRSK2	1.15692433
29	TTK	1.14425270
30	PLK2	1.11797766
31	BCKDK	1.11481545
32	PINK1	1.09094420
33	DYRK2	1.08339418
34	CSNK1G2	1.05845780
35	STK38L	1.04335508
36	PASK	1.03263486
37	STK24	1.02244233
38	DYRK1B	0.99910686
39	EPHB1	0.98331385
40	CSNK1G3	0.98091170
41	ERBB2	0.96542451
42	VRK1	0.96315775
43	WNK4	0.95501703
44	IRAK1	0.94841099
45	STK16	0.89465629
46	CSNK1A1L	0.89243998
47	CSNK1G1	0.88162185
48	DYRK1A	0.86127772
49	STK39	0.85528645
50	MARK1	0.83271409
51	MKNK2	0.80292719
52	NTRK2	0.79624308
53	GRK1	0.77868645
54	BMPR1B	0.75036925
55	ADRBK2	0.71957279
56	NEK9	0.69268808
57	PLK1	0.67648397
58	NUAK1	0.66691517
59	PLK4	0.61703731
60	PRKCG	0.58433894
61	CDC7	0.57474265
62	PRKCE	0.57201087
63	NEK6	0.56651037
64	UHMK1	0.55411374
65	SRPK1	0.53476045
66	PLK3	0.53201038
67	MAP2K4	0.52698835
68	TGFBR1	0.51129570
69	INSRR	0.50714583
70	CDK3	0.46163547
71	MAPKAPK3	0.45898726
72	PKN1	0.45146412
73	AURKA	0.43024150
74	VRK2	0.42943152
75	CAMK2A	0.42751619
76	FER	0.42613586
77	LRRK2	0.41165265
78	RPS6KA4	0.41000221
79	ROCK2	0.41000036
80	PRKACA	0.39248764
81	ZAK	0.38456128
82	PRKCI	0.36484573
83	NTRK3	0.35344831
84	PAK3	0.35100026
85	CHEK2	0.34742714
86	NLK	0.32965515
87	CSNK1A1	0.30992419
88	MAP3K7	0.29817534
89	OXSR1	0.28773364
90	ICK	0.28021804
91	PRKCZ	0.27083402
92	MUSK	0.27066673
93	CHUK	0.26595576
94	MINK1	0.25857500
95	CDK5	0.25096685
96	PRKG1	0.24805443
97	BRSK1	0.23671765
98	DMPK	0.23389634
99	CAMK2G	0.23300881
100	SGK223	0.22588301

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.58964008
2	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.47790473
3	Huntingtons disease_Homo sapiens_hsa05016	3.08936146
4	Chemical carcinogenesis_Homo sapiens_hsa05204	2.88153982
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.84236991
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.57581588
7	Histidine metabolism_Homo sapiens_hsa00340	2.49813658
8	Phenylalanine metabolism_Homo sapiens_hsa00360	2.42625664
9	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.15808781
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.12828077
11	beta-Alanine metabolism_Homo sapiens_hsa00410	2.11332676
12	Protein export_Homo sapiens_hsa03060	2.04523946
13	Tyrosine metabolism_Homo sapiens_hsa00350	2.00559681
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.92129750
15	Glutathione metabolism_Homo sapiens_hsa00480	1.90326657
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.89229535
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68420754
18	Propanoate metabolism_Homo sapiens_hsa00640	1.65964115
19	Butanoate metabolism_Homo sapiens_hsa00650	1.62615729
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.62428554
21	Caffeine metabolism_Homo sapiens_hsa00232	1.59589099
22	Retinol metabolism_Homo sapiens_hsa00830	1.59276290
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.57511305
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.51386403
25	Peroxisome_Homo sapiens_hsa04146	1.48662422
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.43892247
27	Nicotine addiction_Homo sapiens_hsa05033	1.42720257
28	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.42442251
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.39712050
30	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.37373545
31	Hippo signaling pathway_Homo sapiens_hsa04390	1.34906956
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.28470372
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.28292918
34	Parkinsons disease_Homo sapiens_hsa05012	1.24163579
35	Tight junction_Homo sapiens_hsa04530	1.21996264
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.18280032
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.16704588
38	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.14517662
39	Phototransduction_Homo sapiens_hsa04744	1.12409912
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12248252
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.04534903
42	Fatty acid degradation_Homo sapiens_hsa00071	1.02505861
43	Axon guidance_Homo sapiens_hsa04360	1.02094759
44	Taste transduction_Homo sapiens_hsa04742	1.01773916
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.01476951
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.00931098
47	Notch signaling pathway_Homo sapiens_hsa04330	0.99302287
48	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.96640603
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93616705
50	ABC transporters_Homo sapiens_hsa02010	0.91228032
51	Olfactory transduction_Homo sapiens_hsa04740	0.87223728
52	Circadian rhythm_Homo sapiens_hsa04710	0.87096976
53	Alzheimers disease_Homo sapiens_hsa05010	0.85661283
54	Cocaine addiction_Homo sapiens_hsa05030	0.82863863
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.79669309
56	Melanogenesis_Homo sapiens_hsa04916	0.78103489
57	Wnt signaling pathway_Homo sapiens_hsa04310	0.77755737
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.76750076
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75806915
60	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.73218263
61	Folate biosynthesis_Homo sapiens_hsa00790	0.71640711
62	Salivary secretion_Homo sapiens_hsa04970	0.70796403
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.70292996
64	Metabolic pathways_Homo sapiens_hsa01100	0.68735200
65	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.68477159
66	Sphingolipid metabolism_Homo sapiens_hsa00600	0.67843688
67	Basal transcription factors_Homo sapiens_hsa03022	0.67598294
68	Arginine and proline metabolism_Homo sapiens_hsa00330	0.63836055
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63561683
70	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.59992918
71	Ribosome_Homo sapiens_hsa03010	0.57300450
72	Purine metabolism_Homo sapiens_hsa00230	0.56237025
73	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.55456871
74	Spliceosome_Homo sapiens_hsa03040	0.54833641
75	RNA polymerase_Homo sapiens_hsa03020	0.54031168
76	Circadian entrainment_Homo sapiens_hsa04713	0.53242902
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52450082
78	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.52436864
79	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.52276312
80	Homologous recombination_Homo sapiens_hsa03440	0.51646357
81	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.48719146
82	RNA degradation_Homo sapiens_hsa03018	0.48351366
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48079783
84	GABAergic synapse_Homo sapiens_hsa04727	0.47878729
85	Pyruvate metabolism_Homo sapiens_hsa00620	0.47535184
86	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.45471772
87	Collecting duct acid secretion_Homo sapiens_hsa04966	0.43918701
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.43352991
89	Regulation of autophagy_Homo sapiens_hsa04140	0.42854706
90	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.40453200
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.38851895
92	Serotonergic synapse_Homo sapiens_hsa04726	0.34205418
93	PPAR signaling pathway_Homo sapiens_hsa03320	0.33942878
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.33459997
95	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.33265969
96	Adherens junction_Homo sapiens_hsa04520	0.32102298
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31278338
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31069278
99	Ether lipid metabolism_Homo sapiens_hsa00565	0.30780724
100	Glutamatergic synapse_Homo sapiens_hsa04724	0.29020930

C6ORF118

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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