ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	keratinization (GO:0031424)	8.27473440
2	desmosome organization (GO:0002934)	7.73824503
3	establishment of skin barrier (GO:0061436)	6.72151918
4	regulation of water loss via skin (GO:0033561)	6.27038629
5	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.88920025
6	keratinocyte differentiation (GO:0030216)	5.08555346
7	regulation of hippo signaling (GO:0035330)	5.05029830
8	regulation of gene silencing by RNA (GO:0060966)	4.99655189
9	regulation of posttranscriptional gene silencing (GO:0060147)	4.99655189
10	regulation of gene silencing by miRNA (GO:0060964)	4.99655189
11	hemidesmosome assembly (GO:0031581)	4.66214435
12	multicellular organismal water homeostasis (GO:0050891)	4.62842940
13	intestinal epithelial cell development (GO:0060576)	4.48289924
14	keratinocyte development (GO:0003334)	4.25451484
15	hair cycle (GO:0042633)	4.21568300
16	molting cycle (GO:0042303)	4.21568300
17	epidermal cell differentiation (GO:0009913)	4.19169987
18	keratinocyte proliferation (GO:0043616)	4.19078115
19	gap junction assembly (GO:0016264)	4.09050972
20	negative regulation of keratinocyte proliferation (GO:0010839)	4.04085186
21	peptide cross-linking (GO:0018149)	4.01984490
22	epidermis development (GO:0008544)	3.94439595
23	water homeostasis (GO:0030104)	3.91033437
24	lateral sprouting from an epithelium (GO:0060601)	3.85349255
25	establishment of tissue polarity (GO:0007164)	3.81740161
26	establishment of planar polarity (GO:0001736)	3.81740161
27	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.71140984
28	regulation of mesoderm development (GO:2000380)	3.57387950
29	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	3.56506510
30	regulation of keratinocyte proliferation (GO:0010837)	3.52404675
31	polarized epithelial cell differentiation (GO:0030859)	3.51017437
32	axonemal dynein complex assembly (GO:0070286)	3.43623273
33	establishment of apical/basal cell polarity (GO:0035089)	3.38002431
34	cardiac right ventricle morphogenesis (GO:0003215)	3.34754495
35	kidney morphogenesis (GO:0060993)	3.21542825
36	water-soluble vitamin biosynthetic process (GO:0042364)	3.20262893
37	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.17397913
38	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.16112624
39	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.15768060
40	establishment of monopolar cell polarity (GO:0061162)	3.15768060
41	apical protein localization (GO:0045176)	3.15309376
42	pseudouridine synthesis (GO:0001522)	3.15199188
43	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.13778323
44	negative regulation of telomerase activity (GO:0051974)	3.06298706
45	L-fucose catabolic process (GO:0042355)	2.98422955
46	fucose catabolic process (GO:0019317)	2.98422955
47	L-fucose metabolic process (GO:0042354)	2.98422955
48	regulation of cell fate specification (GO:0042659)	2.96332477
49	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.94728076
50	tight junction assembly (GO:0070830)	2.92382202
51	cilium movement (GO:0003341)	2.91079702
52	negative regulation of cell fate commitment (GO:0010454)	2.88033699
53	epithelial cilium movement (GO:0003351)	2.85287904
54	ectoderm development (GO:0007398)	2.81393270
55	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.79839276
56	behavioral response to nicotine (GO:0035095)	2.71705945
57	nodal signaling pathway (GO:0038092)	2.71004853
58	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	2.70578746
59	cornea development in camera-type eye (GO:0061303)	2.70529072
60	negative regulation of cell fate specification (GO:0009996)	2.64172383
61	epithelial cell maturation (GO:0002070)	2.63671122
62	nucleoside transmembrane transport (GO:1901642)	2.62933507
63	regulation of cell fate commitment (GO:0010453)	2.62919095
64	O-glycan processing (GO:0016266)	2.59705617
65	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.58650828
66	lung-associated mesenchyme development (GO:0060484)	2.58179412
67	cilium or flagellum-dependent cell motility (GO:0001539)	2.58176857
68	axoneme assembly (GO:0035082)	2.52954865
69	negative regulation of T cell differentiation in thymus (GO:0033085)	2.48029462
70	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.47519489
71	branching involved in labyrinthine layer morphogenesis (GO:0060670)	2.46737651
72	asymmetric protein localization (GO:0008105)	2.44255449
73	telomere maintenance via telomerase (GO:0007004)	2.43524818
74	transepithelial transport (GO:0070633)	2.43384253
75	sulfation (GO:0051923)	2.42964425
76	vitamin transmembrane transport (GO:0035461)	2.42588379
77	negative regulation of epidermis development (GO:0045683)	2.41655162
78	positive regulation of fatty acid oxidation (GO:0046321)	2.41122132
79	DNA deamination (GO:0045006)	2.36662782
80	intermediate filament organization (GO:0045109)	2.36007117
81	anterior/posterior axis specification, embryo (GO:0008595)	2.35488223
82	dorsal/ventral axis specification (GO:0009950)	2.34026069
83	primary alcohol catabolic process (GO:0034310)	2.33150405
84	notochord development (GO:0030903)	2.32784357
85	motile cilium assembly (GO:0044458)	2.32557160
86	chaperone-mediated protein transport (GO:0072321)	2.32161366
87	lung lobe morphogenesis (GO:0060463)	2.31719376
88	intermediate filament cytoskeleton organization (GO:0045104)	2.31009767
89	regulation of heart rate by cardiac conduction (GO:0086091)	2.30460434
90	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.29402870
91	branching involved in salivary gland morphogenesis (GO:0060445)	2.28573426
92	negative regulation of gene silencing (GO:0060969)	2.27602510
93	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.27480164
94	regulation of cell proliferation involved in kidney development (GO:1901722)	2.27010161
95	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.26686592
96	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.26686592
97	intermediate filament-based process (GO:0045103)	2.26301269
98	cell-cell junction assembly (GO:0007043)	2.25318399
99	epithelium development (GO:0060429)	2.23541073
100	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.22052623

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	5.85070193
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.10174272
3	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.71325236
4	ESR1_21235772_ChIP-Seq_MCF-7_Human	3.56276742
5	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	3.13448016
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.66952813
7	VDR_22108803_ChIP-Seq_LS180_Human	2.51578497
8	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.32189540
9	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	2.18994494
10	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.00648065
11	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.96171639
12	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.94054446
13	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.93115448
14	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.88971320
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.82199879
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.80739502
17	* GATA4_25053715_ChIP-Seq_YYC3_Human	1.78038142
18	* AHR_22903824_ChIP-Seq_MCF-7_Human	1.63895917
19	* GATA3_24758297_ChIP-Seq_MCF-7_Human	1.63641540
20	* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.62298259
21	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.56459324
22	GATA6_25053715_ChIP-Seq_YYC3_Human	1.47933392
23	* KLF5_25053715_ChIP-Seq_YYC3_Human	1.47642992
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45123203
25	HOXB7_26014856_ChIP-Seq_BT474_Human	1.42044662
26	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.39926231
27	SOX2_20726797_ChIP-Seq_SW620_Human	1.39544504
28	* RUNX1_27514584_Chip-Seq_MCF-7_Human	1.39330717
29	* ARNT_22903824_ChIP-Seq_MCF-7_Human	1.32504055
30	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.31575983
31	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.31575983
32	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.30923187
33	* AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.29404448
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26520939
35	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.25233192
36	* TP63_22573176_ChIP-Seq_HFKS_Human	1.24794200
37	* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.22502302
38	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.22220605
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22059942
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20788423
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20788423
42	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.20608762
43	TP63_23658742_ChIP-Seq_EP156T_Human	1.16747703
44	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.16436313
45	RXR_22108803_ChIP-Seq_LS180_Human	1.15503714
46	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.15166595
47	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.14385529
48	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.13565717
49	P53_21459846_ChIP-Seq_SAOS-2_Human	1.13508348
50	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.13319820
51	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.13225503
52	ERG_20517297_ChIP-Seq_VCAP_Human	1.10067538
53	ERA_21632823_ChIP-Seq_H3396_Human	1.09883226
54	CTCF_27219007_Chip-Seq_Bcells_Human	1.09451982
55	AR_20517297_ChIP-Seq_VCAP_Human	1.06961462
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05502063
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.05114703
58	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03319219
59	* ELF5_23300383_ChIP-Seq_T47D_Human	1.02998920
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98997360
61	CTCF_20526341_ChIP-Seq_ESCs_Human	0.98149577
62	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.97923324
63	BCAT_22108803_ChIP-Seq_LS180_Human	0.97758491
64	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.97659931
65	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.97075705
66	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.97050921
67	RBPJ_21746931_ChIP-Seq_IB4_Human	0.95855569
68	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.94612334
69	PRDM14_21183938_ChIP-Seq_MESCs_Mouse	0.94395139
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.93955401
71	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.93852952
72	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.92944719
73	CDX2_22108803_ChIP-Seq_LS180_Human	0.92801037
74	* FOXH1_21741376_ChIP-Seq_ESCs_Human	0.92523282
75	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.91151615
76	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.90927064
77	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.90309207
78	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.89092591
79	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.88260523
80	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.87825060
81	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.87504816
82	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.86974744
83	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.86831526
84	* ATF3_27146783_Chip-Seq_COLON_Human	0.86219108
85	RACK7_27058665_Chip-Seq_MCF-7_Human	0.85519716
86	ETV1_20927104_ChIP-Seq_GIST48_Human	0.85423635
87	NCOR_22424771_ChIP-Seq_293T_Human	0.85388712
88	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.84875209
89	* MYC_19829295_ChIP-Seq_ESCs_Human	0.84683237
90	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.83460593
91	E2F1_20622854_ChIP-Seq_HELA_Human	0.82734717
92	CJUN_26792858_Chip-Seq_BT549_Human	0.81915484
93	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.81164221
94	AR_21572438_ChIP-Seq_LNCaP_Human	0.80641504
95	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.80237164
96	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.80150232
97	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.78953383
98	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.78733557
99	AR_25329375_ChIP-Seq_VCAP_Human	0.78370905
100	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.77925667

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	5.17652763
2	MP0002796_impaired_skin_barrier	4.97238855
3	MP0000579_abnormal_nail_morphology	3.97551568
4	MP0002254_reproductive_system_inflammat	3.58849219
5	MP0000566_synostosis	3.11151321
6	MP0010678_abnormal_skin_adnexa	3.09042241
7	MP0000383_abnormal_hair_follicle	2.96524525
8	MP0003941_abnormal_skin_development	2.84393873
9	MP0005501_abnormal_skin_physiology	2.81327165
10	MP0005275_abnormal_skin_tensile	2.80966203
11	MP0009379_abnormal_foot_pigmentation	2.67893658
12	MP0002098_abnormal_vibrissa_morphology	2.60619696
13	MP0004043_abnormal_pH_regulation	2.50173083
14	MP0000467_abnormal_esophagus_morphology	2.24607210
15	MP0003878_abnormal_ear_physiology	2.20585171
16	MP0005377_hearing/vestibular/ear_phenot	2.20585171
17	MP0004264_abnormal_extraembryonic_tissu	2.17850559
18	MP0001216_abnormal_epidermal_layer	2.05040137
19	MP0000762_abnormal_tongue_morphology	1.92995191
20	MP0010771_integument_phenotype	1.83039646
21	MP0000427_abnormal_hair_cycle	1.80839336
22	MP0004885_abnormal_endolymph	1.68747529
23	MP0004133_heterotaxia	1.65155177
24	MP0010030_abnormal_orbit_morphology	1.64160279
25	MP0000377_abnormal_hair_follicle	1.61025846
26	MP0000647_abnormal_sebaceous_gland	1.59194171
27	MP0004782_abnormal_surfactant_physiolog	1.57808580
28	MP0004019_abnormal_vitamin_homeostasis	1.56170039
29	MP0000537_abnormal_urethra_morphology	1.55590544
30	MP0003693_abnormal_embryo_hatching	1.52039217
31	MP0003937_abnormal_limbs/digits/tail_de	1.45017807
32	MP0002060_abnormal_skin_morphology	1.44559298
33	MP0002876_abnormal_thyroid_physiology	1.38050543
34	MP0001485_abnormal_pinna_reflex	1.36796856
35	MP0008872_abnormal_physiological_respon	1.35973988
36	MP0009780_abnormal_chondrocyte_physiolo	1.35837497
37	MP0003718_maternal_effect	1.35814077
38	MP0006292_abnormal_olfactory_placode	1.33954543
39	MP0003453_abnormal_keratinocyte_physiol	1.32834690
40	MP0002653_abnormal_ependyma_morphology	1.32155442
41	MP0008875_abnormal_xenobiotic_pharmacok	1.30340517
42	MP0002234_abnormal_pharynx_morphology	1.28865988
43	MP0000678_abnormal_parathyroid_gland	1.26785427
44	MP0003119_abnormal_digestive_system	1.18928506
45	MP0003890_abnormal_embryonic-extraembry	1.16787342
46	MP0003011_delayed_dark_adaptation	1.14881087
47	MP0000470_abnormal_stomach_morphology	1.14514446
48	MP0000049_abnormal_middle_ear	1.12667163
49	MP0001188_hyperpigmentation	1.09734669
50	MP0003315_abnormal_perineum_morphology	1.08844883
51	MP0002160_abnormal_reproductive_system	1.07369380
52	MP0010352_gastrointestinal_tract_polyps	1.03691535
53	MP0009053_abnormal_anal_canal	1.01587416
54	MP0001765_abnormal_ion_homeostasis	0.98367679
55	MP0003646_muscle_fatigue	0.97859813
56	MP0004185_abnormal_adipocyte_glucose	0.97791363
57	MP0002938_white_spotting	0.97374097
58	MP0002111_abnormal_tail_morphology	0.94398688
59	MP0003755_abnormal_palate_morphology	0.92388504
60	MP0008789_abnormal_olfactory_epithelium	0.91808505
61	MP0003638_abnormal_response/metabolism_	0.91452923
62	MP0005670_abnormal_white_adipose	0.89633123
63	MP0005083_abnormal_biliary_tract	0.88027546
64	MP0000631_abnormal_neuroendocrine_gland	0.86290767
65	MP0002282_abnormal_trachea_morphology	0.84646895
66	MP0000627_abnormal_mammary_gland	0.83257889
67	MP0000367_abnormal_coat/_hair	0.81626129
68	MP0005389_reproductive_system_phenotype	0.79819077
69	MP0003936_abnormal_reproductive_system	0.79582021
70	MP0002277_abnormal_respiratory_mucosa	0.77055278
71	MP0005551_abnormal_eye_electrophysiolog	0.76836522
72	MP0003938_abnormal_ear_development	0.76378045
73	MP0009384_cardiac_valve_regurgitation	0.76344639
74	MP0005645_abnormal_hypothalamus_physiol	0.75533469
75	MP0003566_abnormal_cell_adhesion	0.74279411
76	MP0005646_abnormal_pituitary_gland	0.74152284
77	MP0009931_abnormal_skin_appearance	0.74088703
78	MP0001293_anophthalmia	0.73898285
79	MP0000538_abnormal_urinary_bladder	0.73875323
80	MP0003195_calcinosis	0.73814155
81	MP0000613_abnormal_salivary_gland	0.73550499
82	MP0004381_abnormal_hair_follicle	0.71147857
83	MP0004957_abnormal_blastocyst_morpholog	0.69587475
84	MP0000462_abnormal_digestive_system	0.68573753
85	MP0005360_urolithiasis	0.67736011
86	MP0002249_abnormal_larynx_morphology	0.67351275
87	MP0005636_abnormal_mineral_homeostasis	0.65152269
88	MP0001919_abnormal_reproductive_system	0.63572084
89	MP0001849_ear_inflammation	0.62956716
90	MP0008877_abnormal_DNA_methylation	0.61937439
91	MP0002233_abnormal_nose_morphology	0.61318170
92	MP0001346_abnormal_lacrimal_gland	0.60650500
93	MP0002736_abnormal_nociception_after	0.59622292
94	MP0002697_abnormal_eye_size	0.59521861
95	MP0001873_stomach_inflammation	0.58995515
96	MP0001286_abnormal_eye_development	0.58371077
97	MP0000432_abnormal_head_morphology	0.57882817
98	MP0002085_abnormal_embryonic_tissue	0.57659606
99	MP0001881_abnormal_mammary_gland	0.57406417
100	MP0001664_abnormal_digestion	0.55059602

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of nail color (HP:0100643)	4.12691623
2	Fragile nails (HP:0001808)	4.10187868
3	Chronic bronchitis (HP:0004469)	3.89065831
4	Plantar hyperkeratosis (HP:0007556)	3.88168091
5	Oral leukoplakia (HP:0002745)	3.83019715
6	Palmoplantar hyperkeratosis (HP:0000972)	3.77467804
7	Congenital ichthyosiform erythroderma (HP:0007431)	3.71927794
8	Right ventricular cardiomyopathy (HP:0011663)	3.56288872
9	Palmar hyperkeratosis (HP:0010765)	3.54243847
10	Woolly hair (HP:0002224)	3.45155483
11	Erythroderma (HP:0001019)	3.34300807
12	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.34280876
13	Alopecia of scalp (HP:0002293)	3.27256812
14	Lip pit (HP:0100267)	3.22088393
15	Amelogenesis imperfecta (HP:0000705)	3.07667727
16	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.05722629
17	Onycholysis (HP:0001806)	3.04782149
18	Parakeratosis (HP:0001036)	2.89382233
19	Pili torti (HP:0003777)	2.86385800
20	Sparse eyelashes (HP:0000653)	2.85732639
21	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.76269259
22	Absent/shortened dynein arms (HP:0200106)	2.76269259
23	Milia (HP:0001056)	2.69850392
24	Abnormal respiratory motile cilium morphology (HP:0005938)	2.69584683
25	Abnormal respiratory epithelium morphology (HP:0012253)	2.69584683
26	Decreased circulating renin level (HP:0003351)	2.67999701
27	Hyperactive renin-angiotensin system (HP:0000841)	2.66643940
28	Hypotrichosis (HP:0001006)	2.59748131
29	Hypoplastic labia majora (HP:0000059)	2.58702695
30	Pendular nystagmus (HP:0012043)	2.56280715
31	Sparse scalp hair (HP:0002209)	2.55324631
32	Abnormal respiratory motile cilium physiology (HP:0012261)	2.52263128
33	Abnormality of the axillary hair (HP:0100134)	2.50639444
34	Abnormality of secondary sexual hair (HP:0009888)	2.50639444
35	Thick nail (HP:0001805)	2.49376327
36	Furrowed tongue (HP:0000221)	2.47414427
37	Pancreatic cysts (HP:0001737)	2.44422129
38	Abnormality of renin-angiotensin system (HP:0000847)	2.43723978
39	Breast hypoplasia (HP:0003187)	2.41444785
40	Rhinitis (HP:0012384)	2.36871499
41	Abnormal ciliary motility (HP:0012262)	2.35734696
42	Pancreatic fibrosis (HP:0100732)	2.35589229
43	Abnormality of the labia majora (HP:0012881)	2.30882022
44	Abnormality of midbrain morphology (HP:0002418)	2.30411235
45	Molar tooth sign on MRI (HP:0002419)	2.30411235
46	Abnormal hair laboratory examination (HP:0003328)	2.24604398
47	Tubular atrophy (HP:0000092)	2.20987679
48	Nail dystrophy (HP:0008404)	2.19912828
49	Birth length less than 3rd percentile (HP:0003561)	2.17599022
50	Congenital, generalized hypertrichosis (HP:0004540)	2.17521582
51	Corneal erosion (HP:0200020)	2.15132290
52	True hermaphroditism (HP:0010459)	2.13947022
53	Congenital stationary night blindness (HP:0007642)	2.13682087
54	Depressed nasal tip (HP:0000437)	2.06869950
55	Nephronophthisis (HP:0000090)	2.02675852
56	Aplasia/hypoplasia of the uterus (HP:0008684)	2.02351458
57	Oligodontia (HP:0000677)	2.01190119
58	Abnormality of the renal collecting system (HP:0004742)	1.99203104
59	Abnormality of the salivary glands (HP:0010286)	1.98980182
60	Labial hypoplasia (HP:0000066)	1.98202940
61	Abnormal drinking behavior (HP:0030082)	1.96526687
62	Polydipsia (HP:0001959)	1.96526687
63	Abnormality of the renal medulla (HP:0100957)	1.95980060
64	Duplicated collecting system (HP:0000081)	1.95006511
65	Absent eyelashes (HP:0000561)	1.93352163
66	Hypoplasia of the uterus (HP:0000013)	1.92533067
67	Brittle hair (HP:0002299)	1.90354274
68	Hypoplastic female external genitalia (HP:0012815)	1.89657991
69	Hypoplasia of dental enamel (HP:0006297)	1.88013056
70	Type II lissencephaly (HP:0007260)	1.87338242
71	Chorioretinal atrophy (HP:0000533)	1.84781320
72	Bilateral microphthalmos (HP:0007633)	1.82826374
73	Stenosis of the external auditory canal (HP:0000402)	1.82190939
74	Abnormality of the nasal septum (HP:0000419)	1.82178197
75	Concave nail (HP:0001598)	1.82111828
76	Absent hair (HP:0002298)	1.81016953
77	Abnormality of permanent molar morphology (HP:0011071)	1.80650590
78	Abnormality of the dental root (HP:0006486)	1.80650590
79	Taurodontia (HP:0000679)	1.80650590
80	Nasolacrimal duct obstruction (HP:0000579)	1.80371517
81	Short 1st metacarpal (HP:0010034)	1.78174681
82	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.78174681
83	Bronchiectasis (HP:0002110)	1.78169157
84	Short hallux (HP:0010109)	1.77461768
85	Abnormality of the lacrimal duct (HP:0011481)	1.76726133
86	Hypomagnesemia (HP:0002917)	1.76656273
87	Increased IgE level (HP:0003212)	1.76266462
88	Hyperkalemia (HP:0002153)	1.75833560
89	Abnormality of magnesium homeostasis (HP:0004921)	1.75806299
90	Esophageal atresia (HP:0002032)	1.73874663
91	Hypoplasia of the pons (HP:0012110)	1.72744260
92	Erythema (HP:0010783)	1.72196398
93	Abnormality of the 1st metacarpal (HP:0010009)	1.71144429
94	Abnormality of molar morphology (HP:0011070)	1.70042560
95	Abnormality of molar (HP:0011077)	1.70042560
96	Aplasia/Hypoplasia of the patella (HP:0006498)	1.69939200
97	Chronic hepatic failure (HP:0100626)	1.69912918
98	Non-midline cleft lip (HP:0100335)	1.69801658
99	Pustule (HP:0200039)	1.69580996
100	Renal salt wasting (HP:0000127)	1.68905872

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	5.91688125
2	WNK4	4.07202911
3	STK39	3.67945629
4	MST4	3.26544586
5	MST1R	3.05582597
6	OXSR1	2.52090950
7	NME1	2.47127348
8	ACVR1B	2.45341936
9	GRK1	2.29835816
10	BMPR1B	2.20239077
11	MET	2.07903522
12	PBK	2.05081531
13	FRK	2.04359407
14	STK38L	1.94837208
15	ADRBK2	1.90601841
16	VRK2	1.83062648
17	MAPK15	1.79223309
18	TLK1	1.65036447
19	LATS1	1.61424016
20	ZAK	1.60960646
21	MAPKAPK3	1.58759364
22	CAMK1D	1.54407808
23	PRKCI	1.51414919
24	STK24	1.35804689
25	TGFBR1	1.34645065
26	NUAK1	1.33247208
27	TNIK	1.28888040
28	TAF1	1.25686752
29	LMTK2	1.25507793
30	MAP3K9	1.22392928
31	WNK3	1.15874634
32	FER	1.15299044
33	EPHB2	1.14402285
34	CAMK1G	1.11806759
35	STK3	1.11514702
36	PRKD2	1.09611777
37	MUSK	1.05720119
38	MAP4K2	0.96445383
39	CASK	0.92938026
40	ADRBK1	0.90901985
41	PTK2	0.87578520
42	BRSK2	0.86963724
43	MAP2K6	0.86617989
44	MKNK2	0.84944760
45	NEK2	0.84063168
46	INSRR	0.82268562
47	DAPK2	0.80680205
48	TTK	0.79616492
49	PRKG2	0.78616127
50	DYRK2	0.74076189
51	PINK1	0.71378742
52	RPS6KB2	0.71027251
53	FGFR1	0.70501757
54	PRKCE	0.68263468
55	PLK1	0.62844086
56	BMX	0.61225729
57	MAP2K2	0.61163062
58	WNK1	0.60240681
59	STK16	0.58678372
60	STK38	0.57218758
61	CSNK1A1	0.56605408
62	ERBB2	0.52572291
63	CHEK2	0.51480420
64	VRK1	0.51006065
65	MAP2K1	0.50441877
66	ERBB4	0.50304251
67	FGFR2	0.47313890
68	PTK6	0.46761243
69	MAP3K2	0.46748287
70	PRKAA2	0.46425949
71	AURKB	0.44315189
72	PAK3	0.43265833
73	CHUK	0.42400100
74	SIK1	0.41906542
75	TAOK1	0.40887577
76	BUB1	0.39944220
77	MAPKAPK5	0.39678382
78	NLK	0.39257395
79	CDK7	0.38118698
80	FLT3	0.37672073
81	CSNK1E	0.37613908
82	AURKA	0.36574873
83	RPS6KA2	0.36053979
84	PIK3CA	0.35863839
85	RPS6KA6	0.35760037
86	SMG1	0.33272059
87	LATS2	0.32256055
88	PLK3	0.31937205
89	BCR	0.30535921
90	PRKCH	0.27505557
91	PRKCZ	0.26160044
92	IRAK1	0.25653101
93	MTOR	0.25426642
94	CSNK1G1	0.25118023
95	ABL2	0.24969498
96	PTK2B	0.23330930
97	MELK	0.22036570
98	PRKCA	0.21696716
99	CDC7	0.21035259
100	IGF1R	0.20683403

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.33457705
2	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.14480623
3	Linoleic acid metabolism_Homo sapiens_hsa00591	3.13138090
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.80913293
5	Phototransduction_Homo sapiens_hsa04744	2.31230819
6	RNA polymerase_Homo sapiens_hsa03020	2.19203801
7	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.17005968
8	Ether lipid metabolism_Homo sapiens_hsa00565	2.05091494
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.03095236
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.02302759
11	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.95569484
12	Histidine metabolism_Homo sapiens_hsa00340	1.88043408
13	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.85324617
14	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.82062663
15	Chemical carcinogenesis_Homo sapiens_hsa05204	1.71130711
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.68988193
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.66407412
18	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.64241991
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.61435567
20	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.60928534
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.57733233
22	Retinol metabolism_Homo sapiens_hsa00830	1.51825906
23	Basal transcription factors_Homo sapiens_hsa03022	1.51301138
24	Ribosome_Homo sapiens_hsa03010	1.48486251
25	Caffeine metabolism_Homo sapiens_hsa00232	1.47073669
26	Tight junction_Homo sapiens_hsa04530	1.43341527
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.43009590
28	Basal cell carcinoma_Homo sapiens_hsa05217	1.40015632
29	Fat digestion and absorption_Homo sapiens_hsa04975	1.39090619
30	Huntingtons disease_Homo sapiens_hsa05016	1.38230323
31	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.31595187
32	Homologous recombination_Homo sapiens_hsa03440	1.28716654
33	Sulfur metabolism_Homo sapiens_hsa00920	1.23226777
34	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.22311793
35	One carbon pool by folate_Homo sapiens_hsa00670	1.21317917
36	Hippo signaling pathway_Homo sapiens_hsa04390	1.19980746
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.19781071
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.19005878
39	Mineral absorption_Homo sapiens_hsa04978	1.18400955
40	Sulfur relay system_Homo sapiens_hsa04122	1.14044134
41	Folate biosynthesis_Homo sapiens_hsa00790	1.09718093
42	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.08852067
43	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.06059045
44	beta-Alanine metabolism_Homo sapiens_hsa00410	1.03896579
45	Glutathione metabolism_Homo sapiens_hsa00480	1.01975454
46	Steroid biosynthesis_Homo sapiens_hsa00100	0.98885367
47	Glycerolipid metabolism_Homo sapiens_hsa00561	0.95983503
48	Parkinsons disease_Homo sapiens_hsa05012	0.91110328
49	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.90807488
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.89628622
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86534451
52	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.85001192
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84254327
54	Arginine and proline metabolism_Homo sapiens_hsa00330	0.81778054
55	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.81273519
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.78174323
57	Protein export_Homo sapiens_hsa03060	0.77631464
58	RNA degradation_Homo sapiens_hsa03018	0.77562344
59	Sphingolipid metabolism_Homo sapiens_hsa00600	0.75590770
60	ECM-receptor interaction_Homo sapiens_hsa04512	0.75533247
61	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.74877798
62	Metabolic pathways_Homo sapiens_hsa01100	0.74202639
63	Pyrimidine metabolism_Homo sapiens_hsa00240	0.74185407
64	Taste transduction_Homo sapiens_hsa04742	0.73609031
65	Serotonergic synapse_Homo sapiens_hsa04726	0.73364941
66	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.72217117
67	Protein digestion and absorption_Homo sapiens_hsa04974	0.71384960
68	Alzheimers disease_Homo sapiens_hsa05010	0.71282441
69	Salivary secretion_Homo sapiens_hsa04970	0.70516332
70	Tyrosine metabolism_Homo sapiens_hsa00350	0.70379628
71	Proteasome_Homo sapiens_hsa03050	0.70270189
72	Phenylalanine metabolism_Homo sapiens_hsa00360	0.69988437
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.67703460
74	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.67673822
75	Circadian rhythm_Homo sapiens_hsa04710	0.67066619
76	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.64059065
77	Fanconi anemia pathway_Homo sapiens_hsa03460	0.63789192
78	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.63689411
79	RNA transport_Homo sapiens_hsa03013	0.63191740
80	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.62890297
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.56635611
82	ABC transporters_Homo sapiens_hsa02010	0.55928654
83	Arginine biosynthesis_Homo sapiens_hsa00220	0.55600219
84	Adherens junction_Homo sapiens_hsa04520	0.55330688
85	Renin-angiotensin system_Homo sapiens_hsa04614	0.54674173
86	Wnt signaling pathway_Homo sapiens_hsa04310	0.51844676
87	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.51422204
88	Cardiac muscle contraction_Homo sapiens_hsa04260	0.51392970
89	Axon guidance_Homo sapiens_hsa04360	0.50634652
90	p53 signaling pathway_Homo sapiens_hsa04115	0.48144203
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.47960987
92	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.47581337
93	Purine metabolism_Homo sapiens_hsa00230	0.46898162
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.45903520
95	Butanoate metabolism_Homo sapiens_hsa00650	0.44624411
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.43497189
97	Peroxisome_Homo sapiens_hsa04146	0.43105837
98	Lysine degradation_Homo sapiens_hsa00310	0.42899652
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38615752
100	Pancreatic secretion_Homo sapiens_hsa04972	0.34379836

C6ORF132

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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