ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oxidative phosphorylation (GO:0006119)	5.10585931
2	creatine metabolic process (GO:0006600)	4.45605116
3	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.43380084
4	respiratory electron transport chain (GO:0022904)	4.13933683
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.10158048
6	GDP-mannose metabolic process (GO:0019673)	4.04664173
7	electron transport chain (GO:0022900)	4.01499302
8	aerobic respiration (GO:0009060)	3.92864785
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.84255179
10	ATP synthesis coupled proton transport (GO:0015986)	3.84255179
11	male meiosis I (GO:0007141)	3.83448058
12	piRNA metabolic process (GO:0034587)	3.78170176
13	respiratory chain complex IV assembly (GO:0008535)	3.68031446
14	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.66933699
15	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.57517980
16	potassium ion export (GO:0071435)	3.53342497
17	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.50699402
18	ATP biosynthetic process (GO:0006754)	3.42609166
19	oxaloacetate metabolic process (GO:0006107)	3.35665752
20	synapsis (GO:0007129)	3.35064093
21	meiosis I (GO:0007127)	3.34500343
22	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.33558369
23	metallo-sulfur cluster assembly (GO:0031163)	3.31202169
24	iron-sulfur cluster assembly (GO:0016226)	3.31202169
25	cellular potassium ion homeostasis (GO:0030007)	3.29658455
26	positive regulation of synapse maturation (GO:0090129)	3.25296049
27	DNA methylation involved in gamete generation (GO:0043046)	3.24927533
28	NADH metabolic process (GO:0006734)	3.23973475
29	cytochrome complex assembly (GO:0017004)	3.20958691
30	regulation of oxidative phosphorylation (GO:0002082)	3.18883432
31	succinate metabolic process (GO:0006105)	3.17447375
32	synaptic vesicle maturation (GO:0016188)	3.12615180
33	sodium ion export (GO:0071436)	3.10797832
34	receptor catabolic process (GO:0032801)	3.08418710
35	glutathione biosynthetic process (GO:0006750)	3.04790129
36	ribosomal small subunit biogenesis (GO:0042274)	3.04614521
37	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.03577778
38	adenine nucleotide transport (GO:0051503)	3.02405683
39	protein complex biogenesis (GO:0070271)	3.02400814
40	DNA replication checkpoint (GO:0000076)	3.00446118
41	mitotic nuclear envelope reassembly (GO:0007084)	2.98476001
42	nuclear envelope reassembly (GO:0031468)	2.98476001
43	synaptonemal complex assembly (GO:0007130)	2.97840631
44	synaptic vesicle exocytosis (GO:0016079)	2.97716483
45	tricarboxylic acid cycle (GO:0006099)	2.95716757
46	mitochondrial fusion (GO:0008053)	2.94462054
47	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.94346323
48	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.93277828
49	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.93277828
50	NADH dehydrogenase complex assembly (GO:0010257)	2.93277828
51	gluconeogenesis (GO:0006094)	2.87997607
52	sleep (GO:0030431)	2.87806617
53	ATP hydrolysis coupled proton transport (GO:0015991)	2.86790076
54	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.86790076
55	hydrogen ion transmembrane transport (GO:1902600)	2.85805721
56	neurotransmitter catabolic process (GO:0042135)	2.84770719
57	membrane repolarization (GO:0086009)	2.84534591
58	potassium ion homeostasis (GO:0055075)	2.83418296
59	mitochondrial respiratory chain complex assembly (GO:0033108)	2.81541693
60	protein targeting to mitochondrion (GO:0006626)	2.80093193
61	glutamate secretion (GO:0014047)	2.79141266
62	hexose biosynthetic process (GO:0019319)	2.76920173
63	chromosome organization involved in meiosis (GO:0070192)	2.74797610
64	regulation of mitochondrial translation (GO:0070129)	2.74047636
65	synaptonemal complex organization (GO:0070193)	2.73313536
66	nucleoside transport (GO:0015858)	2.72871578
67	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.71049330
68	regulation of cellular respiration (GO:0043457)	2.71041627
69	establishment of protein localization to mitochondrion (GO:0072655)	2.70471195
70	granulocyte differentiation (GO:0030851)	2.70284997
71	nucleoside transmembrane transport (GO:1901642)	2.69470637
72	nonribosomal peptide biosynthetic process (GO:0019184)	2.69269496
73	mitochondrial calcium ion transport (GO:0006851)	2.67832321
74	chaperone-mediated protein transport (GO:0072321)	2.66922145
75	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	2.66868300
76	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.66778370
77	cellular response to thyroid hormone stimulus (GO:0097067)	2.65833165
78	neuronal action potential propagation (GO:0019227)	2.64701757
79	purine nucleotide transport (GO:0015865)	2.63727143
80	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.63586213
81	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.63586213
82	mitochondrion transport along microtubule (GO:0047497)	2.62663674
83	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.62663674
84	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	2.60220050
85	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.60169021
86	L-phenylalanine metabolic process (GO:0006558)	2.60169021
87	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.59328038
88	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.58260887
89	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.56344946
90	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.54164123
91	ncRNA 3-end processing (GO:0043628)	2.53548119
92	potassium ion import (GO:0010107)	2.53420774
93	RNA localization (GO:0006403)	2.53117548
94	cellular respiration (GO:0045333)	2.52182002
95	positive regulation of TOR signaling (GO:0032008)	2.51787108
96	erythrocyte development (GO:0048821)	2.47307755
97	regulation of relaxation of muscle (GO:1901077)	2.46730223
98	cerebellar Purkinje cell layer development (GO:0021680)	2.46451675
99	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.45469152
100	nucleoside monophosphate biosynthetic process (GO:0009124)	2.45408036

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.23302361
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.01389240
3	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.85947754
4	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.80076405
5	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.64991348
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.63868679
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.41807846
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.40681104
9	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	2.39712644
10	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.37287416
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.30129081
12	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.29164616
13	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.23696913
14	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.08029598
15	LXR_22292898_ChIP-Seq_THP-1_Human	2.04935303
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.02099868
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.98976494
18	P68_20966046_ChIP-Seq_HELA_Human	1.97399766
19	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.92659621
20	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.90708782
21	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.88343256
22	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.86545059
23	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.81983137
24	XRN2_22483619_ChIP-Seq_HELA_Human	1.81135292
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.81116290
26	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.76579485
27	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.75455148
28	ZNF263_19887448_ChIP-Seq_K562_Human	1.71090822
29	* GABP_19822575_ChIP-Seq_HepG2_Human	1.67400898
30	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.65666855
31	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.65439335
32	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.63032351
33	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.62666241
34	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.62051942
35	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.61240337
36	BCL6_27268052_Chip-Seq_Bcells_Human	1.58095108
37	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.58043961
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.57021181
39	VDR_21846776_ChIP-Seq_THP-1_Human	1.56351251
40	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.54387011
41	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.53353518
42	BCOR_27268052_Chip-Seq_Bcells_Human	1.53199050
43	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.50377517
44	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.49307213
45	E2F1_20622854_ChIP-Seq_HELA_Human	1.45012586
46	DCP1A_22483619_ChIP-Seq_HELA_Human	1.44968542
47	PHF8_20622854_ChIP-Seq_HELA_Human	1.43663629
48	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.40093615
49	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.38994934
50	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.38726735
51	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.36596186
52	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.36324430
53	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.36208481
54	* SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.34402429
55	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.34373834
56	RACK7_27058665_Chip-Seq_MCF-7_Human	1.34038812
57	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.32057566
58	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.31529879
59	SA1_27219007_Chip-Seq_Bcells_Human	1.30523244
60	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.29279578
61	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.29037030
62	SMC4_20622854_ChIP-Seq_HELA_Human	1.28068848
63	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.26718947
64	CREB1_26743006_Chip-Seq_LNCaP_Human	1.25964663
65	TTF2_22483619_ChIP-Seq_HELA_Human	1.25894237
66	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.23052169
67	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.22362598
68	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.21532395
69	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.20781829
70	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.17936836
71	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.16449347
72	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.13266728
73	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.12324248
74	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.10695636
75	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.10422399
76	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.10225107
77	CTCF_27219007_Chip-Seq_Bcells_Human	1.09942106
78	CTCF_21964334_Chip-Seq_Bcells_Human	1.09194429
79	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.08617775
80	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.08360834
81	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.07057315
82	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.06878535
83	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.06453592
84	NCOR1_26117541_ChIP-Seq_K562_Human	1.06193024
85	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.04634141
86	KDM5A_27292631_Chip-Seq_BREAST_Human	1.03814259
87	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.03337401
88	* CTCF_20526341_ChIP-Seq_ESCs_Human	1.02395367
89	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.02249232
90	MAF_26560356_Chip-Seq_TH2_Human	1.01559298
91	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.01051547
92	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.00928595
93	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.00818174
94	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.00209173
95	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.00039617
96	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.99680703
97	VDR_23849224_ChIP-Seq_CD4+_Human	0.99379612
98	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97621013
99	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.96695132
100	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.96076480

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	3.78870502
2	MP0006292_abnormal_olfactory_placode	3.34412402
3	MP0005360_urolithiasis	3.06014728
4	MP0004859_abnormal_synaptic_plasticity	3.02416979
5	MP0006036_abnormal_mitochondrial_physio	2.99913396
6	MP0003806_abnormal_nucleotide_metabolis	2.92215649
7	MP0003879_abnormal_hair_cell	2.68988751
8	MP0005423_abnormal_somatic_nervous	2.48694609
9	MP0003880_abnormal_central_pattern	2.17842507
10	MP0004270_analgesia	2.17094848
11	MP0002064_seizures	2.15482660
12	MP0008877_abnormal_DNA_methylation	2.07099960
13	MP0009745_abnormal_behavioral_response	2.06474078
14	MP0003635_abnormal_synaptic_transmissio	1.97701329
15	MP0000678_abnormal_parathyroid_gland	1.97639922
16	MP0002272_abnormal_nervous_system	1.97261914
17	MP0009840_abnormal_foam_cell	1.93794310
18	MP0009046_muscle_twitch	1.91002870
19	MP0002139_abnormal_hepatobiliary_system	1.84219636
20	MP0002638_abnormal_pupillary_reflex	1.81246663
21	MP0002132_abnormal_respiratory_system	1.80490412
22	MP0003787_abnormal_imprinting	1.79856685
23	MP0006035_abnormal_mitochondrial_morpho	1.65608672
24	MP0003123_paternal_imprinting	1.64856377
25	MP0004145_abnormal_muscle_electrophysio	1.61246758
26	MP0003646_muscle_fatigue	1.57229514
27	MP0001968_abnormal_touch/_nociception	1.55546825
28	MP0002063_abnormal_learning/memory/cond	1.52948540
29	MP0001986_abnormal_taste_sensitivity	1.52271179
30	MP0004885_abnormal_endolymph	1.51991166
31	MP0003693_abnormal_embryo_hatching	1.49203407
32	MP0002822_catalepsy	1.43614957
33	MP0001661_extended_life_span	1.42994320
34	MP0008569_lethality_at_weaning	1.41255467
35	MP0005330_cardiomyopathy	1.37762797
36	MP0000747_muscle_weakness	1.37699421
37	MP0008789_abnormal_olfactory_epithelium	1.37159123
38	MP0005636_abnormal_mineral_homeostasis	1.37075920
39	MP0003718_maternal_effect	1.32740970
40	MP0002249_abnormal_larynx_morphology	1.31187065
41	MP0005451_abnormal_body_composition	1.30040741
42	MP0005394_taste/olfaction_phenotype	1.28487227
43	MP0005499_abnormal_olfactory_system	1.28487227
44	MP0002837_dystrophic_cardiac_calcinosis	1.27512231
45	MP0002572_abnormal_emotion/affect_behav	1.26600730
46	MP0001529_abnormal_vocalization	1.25935456
47	MP0001502_abnormal_circadian_rhythm	1.24283434
48	MP0004019_abnormal_vitamin_homeostasis	1.22292575
49	MP0005332_abnormal_amino_acid	1.22020587
50	MP0001764_abnormal_homeostasis	1.20835261
51	MP0002160_abnormal_reproductive_system	1.19764356
52	MP0002734_abnormal_mechanical_nocicepti	1.15324361
53	MP0005365_abnormal_bile_salt	1.13752758
54	MP0001905_abnormal_dopamine_level	1.13683101
55	MP0002210_abnormal_sex_determination	1.12841572
56	MP0000751_myopathy	1.11731460
57	MP0001486_abnormal_startle_reflex	1.11001833
58	MP0008872_abnormal_physiological_respon	1.09724135
59	MP0005535_abnormal_body_temperature	1.07402682
60	MP0001501_abnormal_sleep_pattern	1.07099016
61	MP0001929_abnormal_gametogenesis	1.06752657
62	MP0002736_abnormal_nociception_after	1.06562410
63	MP0002066_abnormal_motor_capabilities/c	1.01645416
64	MP0001970_abnormal_pain_threshold	1.01325268
65	MP0004043_abnormal_pH_regulation	1.01296425
66	MP0001765_abnormal_ion_homeostasis	0.98577915
67	MP0008875_abnormal_xenobiotic_pharmacok	0.97159043
68	MP0001664_abnormal_digestion	0.96049763
69	MP0003111_abnormal_nucleus_morphology	0.95519593
70	MP0005058_abnormal_lysosome_morphology	0.94488678
71	MP0003698_abnormal_male_reproductive	0.93872202
72	MP0005584_abnormal_enzyme/coenzyme_acti	0.91175503
73	MP0002234_abnormal_pharynx_morphology	0.89612618
74	MP0002733_abnormal_thermal_nociception	0.88671349
75	MP0001188_hyperpigmentation	0.87005874
76	MP0003137_abnormal_impulse_conducting	0.86697845
77	MP0009379_abnormal_foot_pigmentation	0.85662061
78	MP0004811_abnormal_neuron_physiology	0.85521861
79	MP0002067_abnormal_sensory_capabilities	0.85303979
80	MP0002876_abnormal_thyroid_physiology	0.85040205
81	MP0001944_abnormal_pancreas_morphology	0.82683299
82	MP0010329_abnormal_lipoprotein_level	0.82031336
83	MP0008874_decreased_physiological_sensi	0.81834879
84	MP0008260_abnormal_autophagy	0.81602016
85	MP0002971_abnormal_brown_adipose	0.81055347
86	MP0002229_neurodegeneration	0.79404227
87	MP0008058_abnormal_DNA_repair	0.78819410
88	MP0003656_abnormal_erythrocyte_physiolo	0.78151482
89	MP0002106_abnormal_muscle_physiology	0.77553907
90	MP0009780_abnormal_chondrocyte_physiolo	0.76229210
91	MP0000681_abnormal_thyroid_gland	0.76104436
92	MP0001145_abnormal_male_reproductive	0.75265039
93	MP0002735_abnormal_chemical_nociception	0.73434211
94	MP0002557_abnormal_social/conspecific_i	0.72298690
95	MP0000749_muscle_degeneration	0.71709744
96	MP0000750_abnormal_muscle_regeneration	0.71579758
97	MP0001666_abnormal_nutrient_absorption	0.71266896
98	MP0004036_abnormal_muscle_relaxation	0.70691700
99	MP0005257_abnormal_intraocular_pressure	0.70545094
100	MP0002118_abnormal_lipid_homeostasis	0.69669615

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal mitochondria in muscle tissue (HP:0008316)	4.12211712
2	Acute necrotizing encephalopathy (HP:0006965)	4.04084927
3	Hepatic necrosis (HP:0002605)	3.79989848
4	Mitochondrial inheritance (HP:0001427)	3.60045638
5	Hepatocellular necrosis (HP:0001404)	3.59685446
6	Acute encephalopathy (HP:0006846)	3.42895806
7	Myokymia (HP:0002411)	3.30738387
8	Reticulocytosis (HP:0001923)	3.29067985
9	Increased CSF lactate (HP:0002490)	3.19969270
10	Testicular atrophy (HP:0000029)	3.14937993
11	Progressive macrocephaly (HP:0004481)	3.10651871
12	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.07092870
13	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.07092870
14	Truncus arteriosus (HP:0001660)	3.03837126
15	Hypoplasia of the fovea (HP:0007750)	2.99285459
16	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.99285459
17	Myopathic facies (HP:0002058)	2.91382732
18	Congenital malformation of the right heart (HP:0011723)	2.80656861
19	Double outlet right ventricle (HP:0001719)	2.80656861
20	Abnormal gallbladder physiology (HP:0012438)	2.78187786
21	Cholecystitis (HP:0001082)	2.78187786
22	Gout (HP:0001997)	2.78132653
23	Hyperthyroidism (HP:0000836)	2.74713867
24	Increased intramyocellular lipid droplets (HP:0012240)	2.73032316
25	Abnormality of reticulocytes (HP:0004312)	2.72840745
26	Exercise-induced myalgia (HP:0003738)	2.64564942
27	Ventricular fibrillation (HP:0001663)	2.62070084
28	Acanthocytosis (HP:0001927)	2.58120857
29	Lactic acidosis (HP:0003128)	2.57545800
30	Abnormality of the aortic arch (HP:0012303)	2.53607006
31	Cerebral edema (HP:0002181)	2.46840587
32	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.45349891
33	Increased muscle lipid content (HP:0009058)	2.42119383
34	Ragged-red muscle fibers (HP:0003200)	2.39513248
35	Rhabdomyolysis (HP:0003201)	2.39304611
36	Short middle phalanx of the 5th finger (HP:0004220)	2.35281342
37	Type I transferrin isoform profile (HP:0003642)	2.34388712
38	Exercise intolerance (HP:0003546)	2.33884608
39	Bundle branch block (HP:0011710)	2.32761464
40	Generalized aminoaciduria (HP:0002909)	2.31034951
41	Brushfield spots (HP:0001088)	2.30056612
42	Petechiae (HP:0000967)	2.29239514
43	Proximal tubulopathy (HP:0000114)	2.28881236
44	Supranuclear gaze palsy (HP:0000605)	2.28540111
45	Muscle fiber inclusion bodies (HP:0100299)	2.27912088
46	Progressive muscle weakness (HP:0003323)	2.27327353
47	Emotional lability (HP:0000712)	2.27110407
48	Abnormality of the fovea (HP:0000493)	2.26086176
49	Respiratory failure (HP:0002878)	2.22154368
50	Polycythemia (HP:0001901)	2.20333394
51	Abnormality of glycolysis (HP:0004366)	2.19222117
52	Increased serum lactate (HP:0002151)	2.18942282
53	Abnormality of lateral ventricle (HP:0030047)	2.11173729
54	Visual hallucinations (HP:0002367)	2.11053590
55	Increased serum pyruvate (HP:0003542)	2.06263979
56	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.06135247
57	Macrocytic anemia (HP:0001972)	2.05267768
58	Poikilocytosis (HP:0004447)	1.98907694
59	Nemaline bodies (HP:0003798)	1.98746756
60	Hyperalaninemia (HP:0003348)	1.97465449
61	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.97465449
62	Abnormality of alanine metabolism (HP:0010916)	1.97465449
63	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.97197284
64	Myoglobinuria (HP:0002913)	1.94773613
65	Delusions (HP:0000746)	1.94640276
66	Aplasia/Hypoplasia of the macula (HP:0008059)	1.94181949
67	Epileptic encephalopathy (HP:0200134)	1.91667760
68	Focal motor seizures (HP:0011153)	1.90316013
69	Ankle clonus (HP:0011448)	1.89922695
70	Deep palmar crease (HP:0006191)	1.89804363
71	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.89443953
72	Cerebral hypomyelination (HP:0006808)	1.88082281
73	Status epilepticus (HP:0002133)	1.87130811
74	Abnormality of urine glucose concentration (HP:0011016)	1.87092329
75	Glycosuria (HP:0003076)	1.87092329
76	Neoplasm of head and neck (HP:0012288)	1.86797788
77	Esophageal neoplasm (HP:0100751)	1.86797788
78	Abnormal gallbladder morphology (HP:0012437)	1.86230815
79	Gliosis (HP:0002171)	1.86106787
80	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.85555157
81	Mask-like facies (HP:0000298)	1.84151165
82	Late onset (HP:0003584)	1.84138627
83	Hyperinsulinemic hypoglycemia (HP:0000825)	1.82887815
84	Limb dystonia (HP:0002451)	1.81964778
85	Abnormality of fatty-acid metabolism (HP:0004359)	1.81635211
86	Abnormal number of erythroid precursors (HP:0012131)	1.81238363
87	Tetraplegia (HP:0002445)	1.80880330
88	Leukodystrophy (HP:0002415)	1.79184278
89	Abnormality of cells of the erythroid lineage (HP:0012130)	1.78163096
90	Dicarboxylic aciduria (HP:0003215)	1.78048236
91	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.78048236
92	Delayed myelination (HP:0012448)	1.76835625
93	Cholelithiasis (HP:0001081)	1.76520172
94	Renal Fanconi syndrome (HP:0001994)	1.76072016
95	Ileus (HP:0002595)	1.74926825
96	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.74771099
97	Febrile seizures (HP:0002373)	1.74578760
98	Reduced antithrombin III activity (HP:0001976)	1.71919588
99	Abnormal glycosylation (HP:0012345)	1.70530485
100	Abnormal protein N-linked glycosylation (HP:0012347)	1.70530485

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	3.84271734
2	PDK2	2.97777723
3	CDK19	2.71757417
4	PHKG2	2.67881894
5	PHKG1	2.67881894
6	SIK2	2.62088702
7	ARAF	2.57922570
8	MAPKAPK3	2.31474076
9	ERN1	2.31035960
10	KSR2	2.29259837
11	CDK12	2.27290559
12	NTRK3	2.25023534
13	MAPK13	2.18037271
14	MAP3K9	2.17973172
15	OBSCN	1.93288215
16	BRAF	1.89857896
17	TAOK3	1.83490870
18	EPHA4	1.80055798
19	MAPK12	1.75062551
20	RIPK4	1.72642506
21	NME2	1.69541823
22	PINK1	1.66327277
23	TESK1	1.66055815
24	TRIB3	1.56349655
25	NME1	1.47721614
26	TAOK1	1.44992389
27	PRKCI	1.42459936
28	ICK	1.40759051
29	MARK2	1.39059317
30	BRSK1	1.33322369
31	VRK2	1.33318522
32	IRAK3	1.28794668
33	CDK8	1.26016496
34	MAP2K6	1.23271371
35	PAK6	1.21936942
36	DAPK1	1.18916650
37	PDPK1	1.15568554
38	TNK2	1.13620370
39	DMPK	1.10396695
40	DAPK2	1.06874102
41	PTK2B	1.06429558
42	MARK1	1.03016754
43	UHMK1	1.01574886
44	RAF1	0.97136154
45	MAPK11	0.93864780
46	PDK1	0.89671291
47	IRAK2	0.84947246
48	STK16	0.84882321
49	AURKA	0.82041921
50	EEF2K	0.80592841
51	WNK4	0.80508296
52	CAMK2G	0.80064983
53	CAMKK1	0.79672830
54	CDC7	0.74623359
55	KSR1	0.74364736
56	EIF2AK1	0.74286581
57	MAP3K1	0.71574530
58	CCNB1	0.69910844
59	HIPK2	0.69224707
60	MUSK	0.67810445
61	LIMK1	0.66553248
62	MAP3K13	0.65500272
63	ABL2	0.65472898
64	CAMK2B	0.64229865
65	PRKD3	0.62674038
66	BCKDK	0.62326368
67	CDK11A	0.62257899
68	ALK	0.62153259
69	MINK1	0.61587141
70	PRPF4B	0.57404948
71	RPS6KB2	0.57166728
72	MAP3K2	0.56856281
73	PRKG2	0.52549781
74	ACVR1B	0.51358405
75	CAMK2D	0.50741626
76	NEK1	0.48240736
77	CDK15	0.48208451
78	CDK14	0.47731491
79	AKT2	0.47302548
80	CAMK1	0.46514234
81	MAP2K4	0.45485438
82	PAK1	0.45039041
83	BMX	0.44313307
84	CDK7	0.43243613
85	GRK5	0.41056861
86	MAP2K3	0.40725513
87	MAP3K11	0.39544079
88	TAOK2	0.39501209
89	CDK18	0.39428602
90	PRKCG	0.37843714
91	STK38	0.36921603
92	CAMK2A	0.36681527
93	PRKD1	0.36283177
94	TTK	0.34080774
95	NTRK2	0.33908532
96	CSNK1E	0.33857796
97	MAP3K8	0.32346727
98	CDK5	0.32034597
99	CHEK1	0.31491223
100	ADRBK2	0.31044326

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.16322129
2	Sulfur relay system_Homo sapiens_hsa04122	2.87683266
3	Parkinsons disease_Homo sapiens_hsa05012	2.77854096
4	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.72961087
5	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.55338855
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.41977410
7	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.31059629
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.30544126
9	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.24833401
10	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.24660887
11	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.13142029
12	Alzheimers disease_Homo sapiens_hsa05010	1.94960671
13	Ribosome_Homo sapiens_hsa03010	1.90770773
14	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.90342472
15	Huntingtons disease_Homo sapiens_hsa05016	1.77645056
16	Folate biosynthesis_Homo sapiens_hsa00790	1.77439866
17	Collecting duct acid secretion_Homo sapiens_hsa04966	1.69647018
18	Pentose phosphate pathway_Homo sapiens_hsa00030	1.68225060
19	Insulin secretion_Homo sapiens_hsa04911	1.64123611
20	Base excision repair_Homo sapiens_hsa03410	1.63220463
21	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.54766711
22	Carbon metabolism_Homo sapiens_hsa01200	1.48566533
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.36333459
24	Nicotine addiction_Homo sapiens_hsa05033	1.34092328
25	Arginine and proline metabolism_Homo sapiens_hsa00330	1.30956446
26	DNA replication_Homo sapiens_hsa03030	1.29153540
27	GABAergic synapse_Homo sapiens_hsa04727	1.27519876
28	Pyruvate metabolism_Homo sapiens_hsa00620	1.17921735
29	Mineral absorption_Homo sapiens_hsa04978	1.16339682
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.16299698
31	Fatty acid elongation_Homo sapiens_hsa00062	1.15895230
32	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.15821349
33	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.12337044
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.11747877
35	Arginine biosynthesis_Homo sapiens_hsa00220	1.06682248
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.06266164
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.02921536
38	Mismatch repair_Homo sapiens_hsa03430	1.02354602
39	Long-term potentiation_Homo sapiens_hsa04720	1.01058999
40	Other glycan degradation_Homo sapiens_hsa00511	1.00907040
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00872146
42	Regulation of autophagy_Homo sapiens_hsa04140	1.00202226
43	Oocyte meiosis_Homo sapiens_hsa04114	0.99949028
44	RNA polymerase_Homo sapiens_hsa03020	0.99861594
45	Proteasome_Homo sapiens_hsa03050	0.97592311
46	Amphetamine addiction_Homo sapiens_hsa05031	0.96983161
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.95810901
48	Phenylalanine metabolism_Homo sapiens_hsa00360	0.95042255
49	Morphine addiction_Homo sapiens_hsa05032	0.92641642
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.90611805
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90173445
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.85827049
53	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.83649723
54	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.83605539
55	Galactose metabolism_Homo sapiens_hsa00052	0.83582970
56	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.80515930
57	Basal transcription factors_Homo sapiens_hsa03022	0.80400441
58	Purine metabolism_Homo sapiens_hsa00230	0.80394665
59	Circadian entrainment_Homo sapiens_hsa04713	0.80278680
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.79721318
61	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.74888945
62	Vibrio cholerae infection_Homo sapiens_hsa05110	0.74729617
63	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.74163852
64	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.70603174
65	Glucagon signaling pathway_Homo sapiens_hsa04922	0.70596760
66	Metabolic pathways_Homo sapiens_hsa01100	0.70369490
67	Dopaminergic synapse_Homo sapiens_hsa04728	0.70264722
68	Calcium signaling pathway_Homo sapiens_hsa04020	0.69974563
69	Bile secretion_Homo sapiens_hsa04976	0.69165649
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.68764626
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.67614527
72	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.67281350
73	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.65352860
74	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.65275789
75	Sulfur metabolism_Homo sapiens_hsa00920	0.63414802
76	Gastric acid secretion_Homo sapiens_hsa04971	0.61117767
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.59433358
78	Cholinergic synapse_Homo sapiens_hsa04725	0.59303772
79	mRNA surveillance pathway_Homo sapiens_hsa03015	0.58554568
80	RNA transport_Homo sapiens_hsa03013	0.57607951
81	Fatty acid metabolism_Homo sapiens_hsa01212	0.53602926
82	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.53024270
83	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52255254
84	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.52159138
85	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51906819
86	Homologous recombination_Homo sapiens_hsa03440	0.51691090
87	Olfactory transduction_Homo sapiens_hsa04740	0.51121670
88	Glutathione metabolism_Homo sapiens_hsa00480	0.47713240
89	Nitrogen metabolism_Homo sapiens_hsa00910	0.47688662
90	Insulin signaling pathway_Homo sapiens_hsa04910	0.45728116
91	Fanconi anemia pathway_Homo sapiens_hsa03460	0.44778362
92	Taste transduction_Homo sapiens_hsa04742	0.44320566
93	Spliceosome_Homo sapiens_hsa03040	0.42152263
94	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.41501251
95	Circadian rhythm_Homo sapiens_hsa04710	0.41333427
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.40720813
97	Pancreatic secretion_Homo sapiens_hsa04972	0.38908815
98	mTOR signaling pathway_Homo sapiens_hsa04150	0.38751720
99	Cocaine addiction_Homo sapiens_hsa05030	0.37480076
100	RNA degradation_Homo sapiens_hsa03018	0.37161225

C6ORF136

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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