ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.46667883
2	L-fucose catabolic process (GO:0042355)	4.61156740
3	fucose catabolic process (GO:0019317)	4.61156740
4	L-fucose metabolic process (GO:0042354)	4.61156740
5	kynurenine metabolic process (GO:0070189)	4.11544299
6	DNA deamination (GO:0045006)	4.03516764
7	indole-containing compound catabolic process (GO:0042436)	3.75496522
8	indolalkylamine catabolic process (GO:0046218)	3.75496522
9	tryptophan catabolic process (GO:0006569)	3.75496522
10	preassembly of GPI anchor in ER membrane (GO:0016254)	3.75480181
11	negative regulation of telomere maintenance (GO:0032205)	3.68630152
12	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.67634660
13	piRNA metabolic process (GO:0034587)	3.53577475
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.45765094
15	respiratory chain complex IV assembly (GO:0008535)	3.45407127
16	indolalkylamine metabolic process (GO:0006586)	3.36053833
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.30988079
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.24874680
19	pseudouridine synthesis (GO:0001522)	3.22408730
20	tryptophan metabolic process (GO:0006568)	3.22405404
21	protein complex biogenesis (GO:0070271)	3.20988264
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.16517249
23	NADH dehydrogenase complex assembly (GO:0010257)	3.16517249
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.16517249
25	mannosylation (GO:0097502)	3.16179641
26	cellular ketone body metabolic process (GO:0046950)	3.14382504
27	mitochondrial respiratory chain complex assembly (GO:0033108)	3.06640148
28	response to pheromone (GO:0019236)	3.03526132
29	protein-cofactor linkage (GO:0018065)	2.99450812
30	cytochrome complex assembly (GO:0017004)	2.96224480
31	ubiquinone biosynthetic process (GO:0006744)	2.91167213
32	nephron epithelium morphogenesis (GO:0072088)	2.88495945
33	nephron tubule morphogenesis (GO:0072078)	2.88495945
34	kidney morphogenesis (GO:0060993)	2.83438106
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.83368200
36	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.83368200
37	recombinational repair (GO:0000725)	2.82679748
38	regulation of mesoderm development (GO:2000380)	2.82663258
39	cornea development in camera-type eye (GO:0061303)	2.80040976
40	regulation of hippo signaling (GO:0035330)	2.79276303
41	ubiquinone metabolic process (GO:0006743)	2.78989898
42	double-strand break repair via homologous recombination (GO:0000724)	2.78618643
43	nonmotile primary cilium assembly (GO:0035058)	2.78401810
44	ketone body metabolic process (GO:1902224)	2.77062096
45	platelet dense granule organization (GO:0060155)	2.76334075
46	DNA methylation involved in gamete generation (GO:0043046)	2.76067987
47	GPI anchor metabolic process (GO:0006505)	2.74535704
48	tRNA modification (GO:0006400)	2.71357914
49	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.70652300
50	axoneme assembly (GO:0035082)	2.69232066
51	cellular biogenic amine catabolic process (GO:0042402)	2.68080047
52	amine catabolic process (GO:0009310)	2.68080047
53	peptidyl-histidine modification (GO:0018202)	2.67783700
54	tRNA processing (GO:0008033)	2.67766581
55	replication fork processing (GO:0031297)	2.66247531
56	DNA double-strand break processing (GO:0000729)	2.65880584
57	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.63728700
58	ATP synthesis coupled proton transport (GO:0015986)	2.63728700
59	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.61531790
60	reflex (GO:0060004)	2.60538198
61	epithelial cilium movement (GO:0003351)	2.59335865
62	regulation of action potential (GO:0098900)	2.58188499
63	regulation of posttranscriptional gene silencing (GO:0060147)	2.57170321
64	regulation of gene silencing by miRNA (GO:0060964)	2.57170321
65	regulation of gene silencing by RNA (GO:0060966)	2.57170321
66	protein K6-linked ubiquitination (GO:0085020)	2.57128677
67	glycerophospholipid catabolic process (GO:0046475)	2.57100279
68	reciprocal meiotic recombination (GO:0007131)	2.57037285
69	reciprocal DNA recombination (GO:0035825)	2.57037285
70	indole-containing compound metabolic process (GO:0042430)	2.54695688
71	cilium morphogenesis (GO:0060271)	2.54497462
72	photoreceptor cell maintenance (GO:0045494)	2.52252217
73	neuronal action potential (GO:0019228)	2.51267280
74	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.51052372
75	regulation of cilium movement (GO:0003352)	2.50671276
76	male meiosis I (GO:0007141)	2.50544840
77	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.50237561
78	maturation of 5.8S rRNA (GO:0000460)	2.48635887
79	C-terminal protein amino acid modification (GO:0018410)	2.48429481
80	regulation of telomere maintenance (GO:0032204)	2.48122324
81	multicellular organism reproduction (GO:0032504)	2.46856629
82	C-terminal protein lipidation (GO:0006501)	2.46568165
83	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.45443650
84	cardiac right ventricle morphogenesis (GO:0003215)	2.45355558
85	GPI anchor biosynthetic process (GO:0006506)	2.43079999
86	auditory receptor cell stereocilium organization (GO:0060088)	2.42474747
87	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.41768350
88	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.41768350
89	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.41402981
90	cilium organization (GO:0044782)	2.39682226
91	behavioral response to ethanol (GO:0048149)	2.39411371
92	regulation of hexokinase activity (GO:1903299)	2.38979222
93	regulation of glucokinase activity (GO:0033131)	2.38979222
94	fucosylation (GO:0036065)	2.37695774
95	detection of light stimulus involved in sensory perception (GO:0050962)	2.35907731
96	detection of light stimulus involved in visual perception (GO:0050908)	2.35907731
97	rhodopsin mediated signaling pathway (GO:0016056)	2.35783293
98	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.35771844
99	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.35191206
100	keratinocyte development (GO:0003334)	2.35131717

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.80164348
2	VDR_22108803_ChIP-Seq_LS180_Human	3.40098349
3	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.89318661
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.57591319
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.50924148
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.44601432
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.40442389
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.33275450
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.32494920
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.31092837
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.27991777
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.18514942
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.15341272
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.10670302
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.07948534
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.05731675
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04765673
18	EWS_26573619_Chip-Seq_HEK293_Human	2.04201309
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.02723765
20	MYC_18940864_ChIP-ChIP_HL60_Human	1.94057652
21	FUS_26573619_Chip-Seq_HEK293_Human	1.92986794
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90028822
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.86709060
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.75475566
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.75297652
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.74992511
27	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.71766889
28	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.70279008
29	P300_19829295_ChIP-Seq_ESCs_Human	1.68970833
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.58693649
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.55114128
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53976879
33	TAF15_26573619_Chip-Seq_HEK293_Human	1.52881873
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.51232230
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.51232230
36	HOXB7_26014856_ChIP-Seq_BT474_Human	1.49432991
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.47119457
38	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.46036597
39	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.44771415
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.39343522
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35139123
42	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34225038
43	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.33681037
44	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.29927266
45	AR_20517297_ChIP-Seq_VCAP_Human	1.28263885
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27866150
47	AR_25329375_ChIP-Seq_VCAP_Human	1.26396604
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25582672
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.25582672
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24536287
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23894630
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23894630
53	* ESR1_21235772_ChIP-Seq_MCF-7_Human	1.21946251
54	* ERA_21632823_ChIP-Seq_H3396_Human	1.21183933
55	TCF4_23295773_ChIP-Seq_U87_Human	1.19862822
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.19542269
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19540326
58	EZH2_22144423_ChIP-Seq_EOC_Human	1.19503446
59	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.17812480
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16105789
61	STAT3_23295773_ChIP-Seq_U87_Human	1.15951037
62	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14477947
63	NCOR_22424771_ChIP-Seq_293T_Human	1.13262120
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12244409
65	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.12235369
66	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.11464689
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10833124
68	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10790947
69	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10367617
70	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.10367617
71	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.09161571
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.09091960
73	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.08593742
74	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.08534631
75	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.07137724
76	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.06573947
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05977230
78	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.05709551
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.05260174
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04147492
81	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.03511395
82	REST_21632747_ChIP-Seq_MESCs_Mouse	1.03486521
83	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.03256176
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02634422
85	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02191755
86	SMAD4_21799915_ChIP-Seq_A2780_Human	1.01548336
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01004147
88	FOXP3_21729870_ChIP-Seq_TREG_Human	0.99429749
89	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98599367
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98329913
91	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98092311
92	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.95208571
93	P53_21459846_ChIP-Seq_SAOS-2_Human	0.94387704
94	* ARNT_22903824_ChIP-Seq_MCF-7_Human	0.94382584
95	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.94253071
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.93835731
97	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.93496723
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.92282477
99	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.91471036
100	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.91469940

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.23524656
2	MP0008877_abnormal_DNA_methylation	2.98227053
3	MP0000427_abnormal_hair_cycle	2.60120545
4	MP0003195_calcinosis	2.51546121
5	MP0008875_abnormal_xenobiotic_pharmacok	2.42399769
6	MP0000383_abnormal_hair_follicle	2.20269906
7	MP0001968_abnormal_touch/_nociception	2.18140001
8	MP0005551_abnormal_eye_electrophysiolog	2.10847779
9	MP0002102_abnormal_ear_morphology	2.08870726
10	MP0002876_abnormal_thyroid_physiology	2.07189022
11	MP0000566_synostosis	2.05988194
12	MP0008872_abnormal_physiological_respon	2.02033429
13	MP0002736_abnormal_nociception_after	1.95784675
14	MP0002938_white_spotting	1.88917049
15	MP0003011_delayed_dark_adaptation	1.88237644
16	MP0003880_abnormal_central_pattern	1.83812981
17	MP0002837_dystrophic_cardiac_calcinosis	1.83762444
18	MP0003136_yellow_coat_color	1.76647795
19	MP0004133_heterotaxia	1.74538116
20	MP0006072_abnormal_retinal_apoptosis	1.72369322
21	MP0009046_muscle_twitch	1.71578093
22	MP0003878_abnormal_ear_physiology	1.67603662
23	MP0005377_hearing/vestibular/ear_phenot	1.67603662
24	MP0005646_abnormal_pituitary_gland	1.67057350
25	MP0002653_abnormal_ependyma_morphology	1.66847273
26	MP0000647_abnormal_sebaceous_gland	1.65287911
27	MP0003787_abnormal_imprinting	1.61002999
28	MP0001529_abnormal_vocalization	1.58200608
29	MP0004885_abnormal_endolymph	1.52749580
30	MP0000579_abnormal_nail_morphology	1.52103587
31	MP0001485_abnormal_pinna_reflex	1.51464406
32	MP0010678_abnormal_skin_adnexa	1.46957554
33	MP0005253_abnormal_eye_physiology	1.46344115
34	MP0000569_abnormal_digit_pigmentation	1.46020652
35	MP0004147_increased_porphyrin_level	1.45514902
36	MP0004043_abnormal_pH_regulation	1.44879141
37	MP0002160_abnormal_reproductive_system	1.44523763
38	MP0002234_abnormal_pharynx_morphology	1.40523851
39	MP0005645_abnormal_hypothalamus_physiol	1.36695073
40	MP0008058_abnormal_DNA_repair	1.36428182
41	MP0003646_muscle_fatigue	1.36283471
42	MP0002277_abnormal_respiratory_mucosa	1.33745482
43	MP0004142_abnormal_muscle_tone	1.33201018
44	MP0000372_irregular_coat_pigmentation	1.32174979
45	MP0009745_abnormal_behavioral_response	1.29182033
46	MP0002751_abnormal_autonomic_nervous	1.28844990
47	MP0002163_abnormal_gland_morphology	1.28438227
48	MP0001919_abnormal_reproductive_system	1.27901778
49	MP0009780_abnormal_chondrocyte_physiolo	1.27156031
50	MP0000631_abnormal_neuroendocrine_gland	1.25618346
51	MP0005389_reproductive_system_phenotype	1.24374636
52	MP0001293_anophthalmia	1.24200326
53	MP0008995_early_reproductive_senescence	1.22610337
54	MP0002098_abnormal_vibrissa_morphology	1.21337680
55	MP0003937_abnormal_limbs/digits/tail_de	1.19716124
56	MP0008789_abnormal_olfactory_epithelium	1.12642477
57	MP0010030_abnormal_orbit_morphology	1.11881170
58	MP0001986_abnormal_taste_sensitivity	1.11291931
59	MP0005084_abnormal_gallbladder_morpholo	1.11181959
60	MP0002272_abnormal_nervous_system	1.09759526
61	MP0001984_abnormal_olfaction	1.08031531
62	MP0002638_abnormal_pupillary_reflex	1.07943478
63	MP0003718_maternal_effect	1.07030009
64	MP0006276_abnormal_autonomic_nervous	1.04321156
65	MP0003890_abnormal_embryonic-extraembry	1.03316535
66	MP0003119_abnormal_digestive_system	1.03029780
67	MP0002254_reproductive_system_inflammat	0.99089120
68	MP0005379_endocrine/exocrine_gland_phen	0.98334561
69	MP0003938_abnormal_ear_development	0.97352774
70	MP0005195_abnormal_posterior_eye	0.97158706
71	MP0005410_abnormal_fertilization	0.95512524
72	MP0003121_genomic_imprinting	0.94745691
73	MP0000049_abnormal_middle_ear	0.94507277
74	MP0008775_abnormal_heart_ventricle	0.94382034
75	MP0002928_abnormal_bile_duct	0.94327476
76	MP0000538_abnormal_urinary_bladder	0.92532528
77	MP0002184_abnormal_innervation	0.91745209
78	MP0001905_abnormal_dopamine_level	0.90811505
79	MP0003122_maternal_imprinting	0.90733348
80	MP0001486_abnormal_startle_reflex	0.89978196
81	MP0001502_abnormal_circadian_rhythm	0.89622364
82	MP0000026_abnormal_inner_ear	0.89299060
83	MP0001873_stomach_inflammation	0.86333583
84	MP0002210_abnormal_sex_determination	0.86104893
85	MP0005075_abnormal_melanosome_morpholog	0.86011259
86	MP0002752_abnormal_somatic_nervous	0.84378403
87	MP0002572_abnormal_emotion/affect_behav	0.83523445
88	MP0002138_abnormal_hepatobiliary_system	0.83184228
89	MP0003936_abnormal_reproductive_system	0.83011410
90	MP0004742_abnormal_vestibular_system	0.82231506
91	MP0003786_premature_aging	0.81427596
92	MP0003283_abnormal_digestive_organ	0.81373997
93	MP0001929_abnormal_gametogenesis	0.81257735
94	MP0003698_abnormal_male_reproductive	0.81027738
95	MP0002557_abnormal_social/conspecific_i	0.80597125
96	MP0002095_abnormal_skin_pigmentation	0.80467006
97	MP0010094_abnormal_chromosome_stability	0.80108992
98	MP0004924_abnormal_behavior	0.79394479
99	MP0005386_behavior/neurological_phenoty	0.79394479
100	MP0005220_abnormal_exocrine_pancreas	0.79304755

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.58119518
2	Pancreatic fibrosis (HP:0100732)	3.90173915
3	True hermaphroditism (HP:0010459)	3.83816745
4	Molar tooth sign on MRI (HP:0002419)	3.81748815
5	Abnormality of midbrain morphology (HP:0002418)	3.81748815
6	Type II lissencephaly (HP:0007260)	3.74606680
7	Congenital stationary night blindness (HP:0007642)	3.51061857
8	Nephronophthisis (HP:0000090)	3.26275352
9	Cystic liver disease (HP:0006706)	3.12391339
10	Pendular nystagmus (HP:0012043)	3.11844434
11	Concave nail (HP:0001598)	2.88661869
12	Abnormality of the renal medulla (HP:0100957)	2.83399719
13	Abnormality of the renal cortex (HP:0011035)	2.68883244
14	Cerebellar dysplasia (HP:0007033)	2.68091983
15	Sclerocornea (HP:0000647)	2.58254705
16	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.52750982
17	Chronic hepatic failure (HP:0100626)	2.51261904
18	Medial flaring of the eyebrow (HP:0010747)	2.51126609
19	Tubular atrophy (HP:0000092)	2.50529571
20	Furrowed tongue (HP:0000221)	2.48846056
21	Congenital, generalized hypertrichosis (HP:0004540)	2.47867136
22	Large for gestational age (HP:0001520)	2.47680231
23	Patellar aplasia (HP:0006443)	2.45960704
24	Abnormality of alanine metabolism (HP:0010916)	2.41429855
25	Hyperalaninemia (HP:0003348)	2.41429855
26	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.41429855
27	Lissencephaly (HP:0001339)	2.40375763
28	Hyperventilation (HP:0002883)	2.36780102
29	Attenuation of retinal blood vessels (HP:0007843)	2.35670694
30	Severe muscular hypotonia (HP:0006829)	2.33463945
31	Abnormality of the labia minora (HP:0012880)	2.32527283
32	Mitochondrial inheritance (HP:0001427)	2.31637222
33	Aplasia/Hypoplasia of the patella (HP:0006498)	2.31195056
34	Hyperglycinuria (HP:0003108)	2.29847597
35	Abolished electroretinogram (ERG) (HP:0000550)	2.27514163
36	Increased CSF lactate (HP:0002490)	2.23561924
37	Abnormal drinking behavior (HP:0030082)	2.23153854
38	Polydipsia (HP:0001959)	2.23153854
39	Acute necrotizing encephalopathy (HP:0006965)	2.22660445
40	Aplasia/hypoplasia of the uterus (HP:0008684)	2.22653191
41	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.20285698
42	Inability to walk (HP:0002540)	2.20270412
43	Abnormality of the pons (HP:0007361)	2.19617287
44	Abnormal biliary tract physiology (HP:0012439)	2.17037825
45	Bile duct proliferation (HP:0001408)	2.17037825
46	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.16328807
47	Optic nerve hypoplasia (HP:0000609)	2.14188768
48	Congenital hepatic fibrosis (HP:0002612)	2.12555034
49	Bilateral microphthalmos (HP:0007633)	2.12515542
50	Amelogenesis imperfecta (HP:0000705)	2.11669141
51	3-Methylglutaconic aciduria (HP:0003535)	2.09423668
52	Increased corneal curvature (HP:0100692)	2.09029050
53	Keratoconus (HP:0000563)	2.09029050
54	Anencephaly (HP:0002323)	2.07348355
55	Postaxial foot polydactyly (HP:0001830)	2.05608780
56	Abnormal rod and cone electroretinograms (HP:0008323)	2.05110901
57	Acute encephalopathy (HP:0006846)	2.04899592
58	Abnormality of the ileum (HP:0001549)	2.04861910
59	Progressive inability to walk (HP:0002505)	2.04080558
60	Meckel diverticulum (HP:0002245)	2.03721983
61	Hypoplasia of the pons (HP:0012110)	2.01021772
62	Hepatocellular necrosis (HP:0001404)	2.00725147
63	Decreased central vision (HP:0007663)	1.99248022
64	Lipid accumulation in hepatocytes (HP:0006561)	1.98214437
65	Stomach cancer (HP:0012126)	1.97707507
66	Progressive macrocephaly (HP:0004481)	1.94707258
67	Gait imbalance (HP:0002141)	1.93152708
68	Absent thumb (HP:0009777)	1.92593867
69	Retinal dysplasia (HP:0007973)	1.91538207
70	Congenital primary aphakia (HP:0007707)	1.91448980
71	Preaxial hand polydactyly (HP:0001177)	1.89279848
72	Male pseudohermaphroditism (HP:0000037)	1.89043479
73	Increased hepatocellular lipid droplets (HP:0006565)	1.89016781
74	Anophthalmia (HP:0000528)	1.88707114
75	Dandy-Walker malformation (HP:0001305)	1.87905895
76	Abnormal mitochondria in muscle tissue (HP:0008316)	1.86690539
77	Hepatic necrosis (HP:0002605)	1.86016576
78	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.85980698
79	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.84694654
80	Chromsome breakage (HP:0040012)	1.84511624
81	Abnormal number of erythroid precursors (HP:0012131)	1.83878613
82	Chorioretinal atrophy (HP:0000533)	1.83675577
83	Hypothermia (HP:0002045)	1.83462930
84	Hypoplasia of the uterus (HP:0000013)	1.82743440
85	Colon cancer (HP:0003003)	1.80687930
86	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.80306364
87	Duplicated collecting system (HP:0000081)	1.79929626
88	Birth length less than 3rd percentile (HP:0003561)	1.79887298
89	Occipital encephalocele (HP:0002085)	1.79622875
90	Nephrogenic diabetes insipidus (HP:0009806)	1.78751529
91	Genital tract atresia (HP:0001827)	1.78712628
92	Abnormality of glycine metabolism (HP:0010895)	1.78666641
93	Abnormality of serine family amino acid metabolism (HP:0010894)	1.78666641
94	Vaginal atresia (HP:0000148)	1.78282572
95	Increased serum lactate (HP:0002151)	1.75860152
96	Methylmalonic acidemia (HP:0002912)	1.75521663
97	Polyuria (HP:0000103)	1.74395404
98	Renal cortical cysts (HP:0000803)	1.72926890
99	Tachypnea (HP:0002789)	1.72111557
100	Optic disc pallor (HP:0000543)	1.71335768

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.95264889
2	BMPR1B	3.27625553
3	ADRBK2	3.26959220
4	ZAK	3.14008731
5	TLK1	2.72298156
6	WNK4	2.63454252
7	WNK3	2.61618148
8	GRK1	2.51737167
9	MAP4K2	2.38461964
10	MAPKAPK3	2.11570396
11	TAOK3	1.96124792
12	NUAK1	1.95034972
13	ACVR1B	1.90403787
14	PIK3CA	1.81847170
15	CASK	1.74004833
16	MUSK	1.69927627
17	INSRR	1.67843067
18	TRIM28	1.66618877
19	FGFR2	1.56497273
20	MKNK2	1.45429518
21	PINK1	1.43964375
22	OXSR1	1.41991203
23	EPHA2	1.40868791
24	STK39	1.37751702
25	VRK2	1.37588017
26	DAPK2	1.35106091
27	MAPK13	1.31754237
28	MAP3K4	1.22986078
29	PHKG1	1.19257808
30	PHKG2	1.19257808
31	BCKDK	1.15821583
32	PRKCI	1.12708632
33	EPHA4	1.12027012
34	BCR	1.11426266
35	PRKCE	1.08918644
36	NME1	1.08103545
37	CHUK	1.07831511
38	STK38L	1.06471183
39	PAK3	1.04809748
40	ADRBK1	1.04566763
41	DYRK2	1.02639624
42	TGFBR1	1.02373383
43	MST4	1.01113056
44	MAP2K7	1.00843510
45	CSNK1G1	0.95044071
46	TNIK	0.92253753
47	CSNK1G3	0.91407309
48	TIE1	0.89669589
49	MKNK1	0.85863238
50	IKBKB	0.80453254
51	CSNK1G2	0.80407549
52	NEK2	0.78774334
53	VRK1	0.78495878
54	CSNK1A1L	0.77731556
55	PNCK	0.77410592
56	SRPK1	0.76733598
57	MAPK15	0.76598683
58	PRKCG	0.76135481
59	EIF2AK3	0.74686635
60	BRSK2	0.73435050
61	MET	0.67610285
62	STK16	0.66003394
63	PLK3	0.64855390
64	PLK1	0.61789737
65	CHEK2	0.59949787
66	ATR	0.58380810
67	PLK2	0.57014205
68	LMTK2	0.56604104
69	TXK	0.55995725
70	IRAK1	0.55764265
71	RPS6KB2	0.55505870
72	MAPKAPK5	0.51278869
73	CSNK1A1	0.51234279
74	WEE1	0.50965480
75	CSNK1D	0.49431250
76	RPS6KA5	0.49246266
77	MARK1	0.46568597
78	EPHB2	0.46062926
79	MAP2K2	0.43520986
80	EIF2AK2	0.41937113
81	MST1R	0.41104260
82	FLT3	0.39634858
83	ERBB3	0.38526988
84	BUB1	0.37435040
85	PRKCZ	0.37167155
86	CDC7	0.36194481
87	ATM	0.35855973
88	DYRK3	0.34982792
89	TSSK6	0.34942255
90	CAMK2D	0.34824572
91	SIK2	0.34562068
92	PRKACA	0.34561130
93	TAF1	0.34202710
94	LIMK1	0.34034986
95	FER	0.32772358
96	PTK2B	0.32148127
97	CAMK2A	0.32030901
98	IKBKE	0.31895329
99	PRKCQ	0.29911606
100	NTRK2	0.29748303

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.85490348
2	Phototransduction_Homo sapiens_hsa04744	2.70022721
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.69009367
4	Homologous recombination_Homo sapiens_hsa03440	2.60302327
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.53712453
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.52636696
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.49448288
8	Caffeine metabolism_Homo sapiens_hsa00232	2.49332896
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.43220014
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.41933593
11	Protein export_Homo sapiens_hsa03060	2.39530142
12	RNA polymerase_Homo sapiens_hsa03020	2.31568234
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.23668906
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.17331985
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.10066271
16	Butanoate metabolism_Homo sapiens_hsa00650	1.97248702
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.88797934
18	Basal transcription factors_Homo sapiens_hsa03022	1.86577615
19	Parkinsons disease_Homo sapiens_hsa05012	1.82986421
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.74779097
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.72836511
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.67244210
23	Proteasome_Homo sapiens_hsa03050	1.52918521
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.51318311
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39483597
26	RNA degradation_Homo sapiens_hsa03018	1.37942096
27	Huntingtons disease_Homo sapiens_hsa05016	1.37288486
28	Nicotine addiction_Homo sapiens_hsa05033	1.37061431
29	One carbon pool by folate_Homo sapiens_hsa00670	1.36335894
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.35277763
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32890387
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.25569174
33	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.22643822
34	Taste transduction_Homo sapiens_hsa04742	1.20528013
35	Ribosome_Homo sapiens_hsa03010	1.19757910
36	Propanoate metabolism_Homo sapiens_hsa00640	1.17141807
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.13813183
38	Alzheimers disease_Homo sapiens_hsa05010	1.12328286
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.08050428
40	Olfactory transduction_Homo sapiens_hsa04740	1.05256455
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.02682503
42	Cardiac muscle contraction_Homo sapiens_hsa04260	1.02105845
43	Peroxisome_Homo sapiens_hsa04146	1.00395827
44	Nucleotide excision repair_Homo sapiens_hsa03420	0.95728489
45	ABC transporters_Homo sapiens_hsa02010	0.95352404
46	Retinol metabolism_Homo sapiens_hsa00830	0.94053437
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92980958
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89746660
49	Mismatch repair_Homo sapiens_hsa03430	0.87001193
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86249362
51	Morphine addiction_Homo sapiens_hsa05032	0.86122554
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84953802
53	Purine metabolism_Homo sapiens_hsa00230	0.84351602
54	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.84310176
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.80634633
56	Sulfur metabolism_Homo sapiens_hsa00920	0.80308608
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78840886
58	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.78423822
59	Non-homologous end-joining_Homo sapiens_hsa03450	0.78185769
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.76048265
61	Metabolic pathways_Homo sapiens_hsa01100	0.75311565
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.75125821
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73926334
64	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.73293932
65	Sulfur relay system_Homo sapiens_hsa04122	0.71697229
66	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.71572578
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.71473864
68	RNA transport_Homo sapiens_hsa03013	0.70093100
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.69933388
70	Regulation of autophagy_Homo sapiens_hsa04140	0.66971199
71	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.65949539
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65383534
73	Insulin secretion_Homo sapiens_hsa04911	0.65070232
74	Histidine metabolism_Homo sapiens_hsa00340	0.64723770
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.64071718
76	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63329882
77	Basal cell carcinoma_Homo sapiens_hsa05217	0.62914146
78	Serotonergic synapse_Homo sapiens_hsa04726	0.61344013
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60154314
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58532584
81	Glutamatergic synapse_Homo sapiens_hsa04724	0.55687433
82	Circadian entrainment_Homo sapiens_hsa04713	0.51693050
83	GABAergic synapse_Homo sapiens_hsa04727	0.51665268
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51436746
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48380059
86	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.46922854
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44634576
88	Salivary secretion_Homo sapiens_hsa04970	0.43654134
89	DNA replication_Homo sapiens_hsa03030	0.42931672
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39810425
91	Hippo signaling pathway_Homo sapiens_hsa04390	0.39497958
92	Mineral absorption_Homo sapiens_hsa04978	0.39303596
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39294594
94	Fatty acid elongation_Homo sapiens_hsa00062	0.39008428
95	Base excision repair_Homo sapiens_hsa03410	0.38548310
96	Spliceosome_Homo sapiens_hsa03040	0.37891054
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32977887
98	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.31254258
99	Circadian rhythm_Homo sapiens_hsa04710	0.30651449
100	p53 signaling pathway_Homo sapiens_hsa04115	0.27597495

C6ORF141

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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