C6ORF15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.14613330
2positive regulation of p38MAPK cascade (GO:1900745)6.88609139
3negative regulation of keratinocyte proliferation (GO:0010839)6.46999437
4establishment of skin barrier (GO:0061436)6.37355963
5regulation of water loss via skin (GO:0033561)6.32576428
6negative regulation of complement activation (GO:0045916)5.31359609
7regulation of p38MAPK cascade (GO:1900744)5.17462589
8activation of Rac GTPase activity (GO:0032863)4.96248262
9natural killer cell mediated immunity (GO:0002228)4.89902806
10natural killer cell mediated cytotoxicity (GO:0042267)4.89902806
11keratinocyte proliferation (GO:0043616)4.65375035
12cell-substrate junction assembly (GO:0007044)4.62831821
13negative regulation of protein activation cascade (GO:2000258)4.60963731
14positive regulation of epidermis development (GO:0045684)4.57687269
15negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)4.50998564
16regulation of transforming growth factor beta2 production (GO:0032909)4.48148385
17keratinocyte development (GO:0003334)4.46563207
18positive regulation of epidermal cell differentiation (GO:0045606)4.36115386
19keratinocyte differentiation (GO:0030216)4.22851107
20multicellular organismal water homeostasis (GO:0050891)4.19073811
21regulation of keratinocyte proliferation (GO:0010837)4.16102853
22fatty acid elongation (GO:0030497)4.11222964
23cytokine production involved in immune response (GO:0002367)4.11015938
24regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.10185401
25ectoderm development (GO:0007398)4.04015248
26epidermis development (GO:0008544)3.97178291
27COPI coating of Golgi vesicle (GO:0048205)3.93425594
28Golgi transport vesicle coating (GO:0048200)3.93425594
29negative regulation of humoral immune response (GO:0002921)3.89753676
30regulation of hair follicle development (GO:0051797)3.87959343
31keratinization (GO:0031424)3.79023326
32establishment of apical/basal cell polarity (GO:0035089)3.72149301
33cell adhesion mediated by integrin (GO:0033627)3.61443037
34mammary gland epithelial cell proliferation (GO:0033598)3.60537177
35positive regulation of hair cycle (GO:0042635)3.54680052
36positive regulation of hair follicle development (GO:0051798)3.54680052
37ephrin receptor signaling pathway (GO:0048013)3.53799313
38regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.49389076
39epidermal cell differentiation (GO:0009913)3.48818351
40negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.48721363
41negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.41552487
42receptor catabolic process (GO:0032801)3.41539062
43branching involved in mammary gland duct morphogenesis (GO:0060444)3.40984794
44dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.37554472
45regulation of sister chromatid cohesion (GO:0007063)3.37111731
46positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.36814026
47regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.34332910
48protein autoprocessing (GO:0016540)3.32518844
49regulation of cardioblast differentiation (GO:0051890)3.28665374
50water homeostasis (GO:0030104)3.27964992
51secondary heart field specification (GO:0003139)3.27177925
52heart field specification (GO:0003128)3.27177925
53respiratory tube development (GO:0030323)3.24265643
54hair follicle development (GO:0001942)3.18475907
55positive regulation of keratinocyte differentiation (GO:0045618)3.17323059
56negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.12308661
57regulation of epidermis development (GO:0045682)3.11807976
58negative regulation of epidermis development (GO:0045683)3.10495565
59gap junction assembly (GO:0016264)3.09783328
60skin morphogenesis (GO:0043589)3.08686418
61cytoskeletal anchoring at plasma membrane (GO:0007016)3.07121397
62intestinal epithelial cell development (GO:0060576)3.02084245
63negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.01964180
64hair cycle (GO:0042633)2.98328644
65molting cycle (GO:0042303)2.98328644
66dorsal/ventral axis specification (GO:0009950)2.97828807
67regulation of cholesterol biosynthetic process (GO:0045540)2.97081459
68tight junction assembly (GO:0070830)2.96937527
69glial cell proliferation (GO:0014009)2.95593057
70negative regulation of transcription by competitive promoter binding (GO:0010944)2.95255316
71cellular copper ion homeostasis (GO:0006878)2.91019160
72epithelial cell-cell adhesion (GO:0090136)2.89605514
73lipopolysaccharide biosynthetic process (GO:0009103)2.88659791
74establishment or maintenance of monopolar cell polarity (GO:0061339)2.88599328
75establishment of monopolar cell polarity (GO:0061162)2.88599328
76negative regulation of stem cell proliferation (GO:2000647)2.86695964
77regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.85290735
78negative regulation of cell fate specification (GO:0009996)2.84897188
79regulation of hair cycle (GO:0042634)2.83569686
80regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.80292674
81negative regulation of chondrocyte differentiation (GO:0032331)2.79494294
82cell communication involved in cardiac conduction (GO:0086065)2.78074349
83maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.77524899
84plasma membrane fusion (GO:0045026)2.76916635
85notochord development (GO:0030903)2.76667719
86L-serine transport (GO:0015825)2.76408345
87endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.75316800
88ventricular cardiac muscle cell action potential (GO:0086005)2.74117974
89bone remodeling (GO:0046849)2.74037174
90amyloid precursor protein metabolic process (GO:0042982)2.73974528
91proteasome assembly (GO:0043248)2.73800003
92establishment of epithelial cell polarity (GO:0090162)2.73355652
93regulation of keratinocyte differentiation (GO:0045616)2.70756677
94intermediate filament organization (GO:0045109)2.69547388
95asymmetric protein localization (GO:0008105)2.69180532
96establishment of tissue polarity (GO:0007164)2.65641916
97establishment of planar polarity (GO:0001736)2.65641916
98regulation of translational fidelity (GO:0006450)2.64909547
99hemidesmosome assembly (GO:0031581)11.3867512
100bundle of His cell to Purkinje myocyte communication (GO:0086069)10.1854946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.84499236
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human5.34946770
3ZNF263_19887448_ChIP-Seq_K562_Human3.88994145
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.75520402
5SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.10494819
6SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.10494819
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.44335333
8P63_26484246_Chip-Seq_KERATINOCYTES_Human2.22251641
9ATF3_27146783_Chip-Seq_COLON_Human2.04025518
10CDX2_20551321_ChIP-Seq_CACO-2_Human2.01104567
11SOX9_24532713_ChIP-Seq_HFSC_Mouse2.00836516
12TP63_17297297_ChIP-ChIP_HaCaT_Human11.8108345
13RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99823566
14PPAR_26484153_Chip-Seq_NCI-H1993_Human1.92161715
15TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.91757320
16KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.91281495
17GATA1_22025678_ChIP-Seq_K562_Human1.85607337
18KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.82637004
19AR_21909140_ChIP-Seq_LNCAP_Human1.81193155
20SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.79821622
21CLOCK_20551151_ChIP-Seq_293T_Human1.71772763
22RUNX1_27514584_Chip-Seq_MCF-7_Human1.69109412
23ELK1_22589737_ChIP-Seq_MCF10A_Human1.67726651
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65637130
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.63824997
26GATA4_25053715_ChIP-Seq_YYC3_Human1.62658258
27ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.62251425
28PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.57081021
29GATA6_25053715_ChIP-Seq_YYC3_Human1.53232599
30KLF5_25053715_ChIP-Seq_YYC3_Human1.52989935
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.52531625
32FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.52413130
33GATA3_24758297_ChIP-Seq_MCF-7_Human1.50235717
34RACK7_27058665_Chip-Seq_MCF-7_Human1.49256974
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48405829
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47966612
37EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.47707975
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.46013889
39* SOX2_20726797_ChIP-Seq_SW620_Human1.45896823
40HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43238643
41DCP1A_22483619_ChIP-Seq_HELA_Human1.43044935
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40457806
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40259377
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.38251540
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.36296940
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34420788
47UBF1/2_26484160_Chip-Seq_HMECs_Human1.33596134
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31139069
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28496204
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.28054193
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27353822
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.23169998
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18753970
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17651617
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15666348
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14936625
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11136386
58TP63_23658742_ChIP-Seq_EP156T_Human1.11128688
59JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10782690
60TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10448388
61XRN2_22483619_ChIP-Seq_HELA_Human1.07545281
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06299872
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05547063
64TP53_22127205_ChIP-Seq_IMR90_Human1.05503395
65PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01368843
66GABP_17652178_ChIP-ChIP_JURKAT_Human1.01351314
67ELF5_23300383_ChIP-Seq_T47D_Human0.95706434
68TP63_22573176_ChIP-Seq_HFKS_Human0.95442702
69KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94123781
70CJUN_26792858_Chip-Seq_BT549_Human0.92119175
71JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91137988
72STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89867059
73MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89336877
74JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88530142
75BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88097450
76MYC_19030024_ChIP-ChIP_MESCs_Mouse0.87647443
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87547796
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.86202824
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85113265
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84977235
81E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84241923
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83723920
83CREB1_15753290_ChIP-ChIP_HEK293T_Human0.82496427
84EP300_21415370_ChIP-Seq_HL-1_Mouse0.81265403
85TBX20_22328084_ChIP-Seq_HEART_Mouse0.80921597
86TBX20_22080862_ChIP-Seq_HEART_Mouse0.80921597
87TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79108696
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78297202
89ELK1_19687146_ChIP-ChIP_HELA_Human0.78085668
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75423802
91ZFX_18555785_ChIP-Seq_MESCs_Mouse0.75262839
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.74747057
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.73089368
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.72759301
95NANOG_18692474_ChIP-Seq_MEFs_Mouse0.72287564
96TET1_21490601_ChIP-Seq_MESCs_Mouse0.71493854
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.69737161
98MYC_18358816_ChIP-ChIP_MESCs_Mouse0.69396848
99SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68577082
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.67786109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology6.39224732
2MP0010234_abnormal_vibrissa_follicle5.93167136
3MP0002796_impaired_skin_barrier4.04160863
4MP0005275_abnormal_skin_tensile3.67505994
5MP0010678_abnormal_skin_adnexa3.65374841
6MP0002098_abnormal_vibrissa_morphology3.61363477
7MP0001986_abnormal_taste_sensitivity3.33233672
8MP0000383_abnormal_hair_follicle3.13100714
9MP0005501_abnormal_skin_physiology2.91162972
10MP0002060_abnormal_skin_morphology2.76303209
11MP0004264_abnormal_extraembryonic_tissu2.68537511
12MP0000762_abnormal_tongue_morphology2.63318498
13MP0001881_abnormal_mammary_gland2.62998403
14MP0003566_abnormal_cell_adhesion2.51318423
15MP0010771_integument_phenotype2.49265321
16MP0000427_abnormal_hair_cycle2.47784218
17MP0001216_abnormal_epidermal_layer2.45356622
18MP0002254_reproductive_system_inflammat2.44530907
19MP0000377_abnormal_hair_follicle2.38585776
20MP0004272_abnormal_basement_membrane2.16644523
21MP0005451_abnormal_body_composition2.12108834
22MP0009053_abnormal_anal_canal2.11143384
23MP0000537_abnormal_urethra_morphology2.07742616
24MP0008260_abnormal_autophagy2.07223134
25MP0000467_abnormal_esophagus_morphology2.06556286
26MP0003941_abnormal_skin_development2.05600322
27MP0003453_abnormal_keratinocyte_physiol2.02766413
28MP0002234_abnormal_pharynx_morphology1.97137854
29MP0003705_abnormal_hypodermis_morpholog1.93434923
30MP0000627_abnormal_mammary_gland1.86688875
31MP0000647_abnormal_sebaceous_gland1.83583810
32MP0003693_abnormal_embryo_hatching1.76438904
33MP0001661_extended_life_span1.72326710
34MP0001849_ear_inflammation1.63760649
35MP0000566_synostosis1.55870904
36MP0003950_abnormal_plasma_membrane1.53928864
37MP0010352_gastrointestinal_tract_polyps1.36732086
38MP0004957_abnormal_blastocyst_morpholog1.34702446
39MP0005023_abnormal_wound_healing1.30251657
40MP0003806_abnormal_nucleotide_metabolis1.28280243
41MP0004381_abnormal_hair_follicle1.26866408
42MP0004947_skin_inflammation1.17830570
43MP0003315_abnormal_perineum_morphology1.14678683
44MP0002736_abnormal_nociception_after1.12611414
45MP0000749_muscle_degeneration1.12380485
46MP0005257_abnormal_intraocular_pressure1.11232109
47MP0009931_abnormal_skin_appearance1.10690131
48MP0000678_abnormal_parathyroid_gland1.07955850
49MP0002282_abnormal_trachea_morphology1.07232118
50MP0005408_hypopigmentation1.00664058
51MP0000858_altered_metastatic_potential0.97846030
52MP0004782_abnormal_surfactant_physiolog0.93795876
53MP0000367_abnormal_coat/_hair0.92633666
54MP0001191_abnormal_skin_condition0.89075686
55MP0003786_premature_aging0.89018479
56MP0003755_abnormal_palate_morphology0.86106011
57MP0000538_abnormal_urinary_bladder0.79945596
58MP0008932_abnormal_embryonic_tissue0.78654341
59MP0002111_abnormal_tail_morphology0.77472371
60MP0005076_abnormal_cell_differentiation0.77314258
61MP0002697_abnormal_eye_size0.77000082
62MP0009780_abnormal_chondrocyte_physiolo0.76478977
63MP0001727_abnormal_embryo_implantation0.76099023
64MP0000733_abnormal_muscle_development0.74325433
65MP0002877_abnormal_melanocyte_morpholog0.74100639
66MP0001243_abnormal_dermal_layer0.73664605
67MP0003385_abnormal_body_wall0.68660348
68MP0000747_muscle_weakness0.67857830
69MP0003111_abnormal_nucleus_morphology0.66708782
70MP0001851_eye_inflammation0.65688823
71MP0002089_abnormal_postnatal_growth/wei0.64659032
72MP0009379_abnormal_foot_pigmentation0.63383434
73MP0003718_maternal_effect0.62611258
74MP0002136_abnormal_kidney_physiology0.60207896
75MP0003077_abnormal_cell_cycle0.59603523
76MP0005360_urolithiasis0.59543160
77MP0000358_abnormal_cell_content/0.59522392
78MP0010030_abnormal_orbit_morphology0.59292569
79MP0000751_myopathy0.57499760
80MP0001968_abnormal_touch/_nociception0.57067725
81MP0003936_abnormal_reproductive_system0.56616328
82MP0001340_abnormal_eyelid_morphology0.56579800
83MP0005197_abnormal_uvea_morphology0.55735802
84MP0008057_abnormal_DNA_replication0.54982446
85MP0002396_abnormal_hematopoietic_system0.51825300
86MP0004233_abnormal_muscle_weight0.51062412
87MP0002084_abnormal_developmental_patter0.51059217
88MP0001672_abnormal_embryogenesis/_devel0.50550444
89MP0005380_embryogenesis_phenotype0.50550444
90MP0001730_embryonic_growth_arrest0.50189918
91MP0000432_abnormal_head_morphology0.49437989
92MP0001853_heart_inflammation0.47966465
93MP0004185_abnormal_adipocyte_glucose0.46621043
94MP0009643_abnormal_urine_homeostasis0.46081750
95MP0008775_abnormal_heart_ventricle0.46080827
96MP0003984_embryonic_growth_retardation0.45906090
97MP0005621_abnormal_cell_physiology0.45455709
98MP0002177_abnormal_outer_ear0.45451494
99MP0002086_abnormal_extraembryonic_tissu0.45018788
100MP0002088_abnormal_embryonic_growth/wei0.43140744

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.41880823
2Onycholysis (HP:0001806)7.85283692
3Milia (HP:0001056)6.40605674
4Fragile nails (HP:0001808)6.09584891
5Abnormal hair laboratory examination (HP:0003328)5.98735323
6Plantar hyperkeratosis (HP:0007556)5.59514597
7Follicular hyperkeratosis (HP:0007502)5.32849465
8Right ventricular cardiomyopathy (HP:0011663)5.29973630
9Abnormality of nail color (HP:0100643)5.12735832
10Atrophic scars (HP:0001075)5.08325214
11Sparse eyelashes (HP:0000653)4.80293603
12Aplasia cutis congenita (HP:0001057)4.40878420
13Hypotrichosis (HP:0001006)4.20933768
14Woolly hair (HP:0002224)4.15838769
15Amniotic constriction ring (HP:0009775)4.12482484
16Abnormality of placental membranes (HP:0011409)4.12482484
17Popliteal pterygium (HP:0009756)3.92619992
18Congenital, generalized hypertrichosis (HP:0004540)3.87107303
19Nail dystrophy (HP:0008404)3.77457807
20Palmoplantar hyperkeratosis (HP:0000972)3.44683883
21Palmar hyperkeratosis (HP:0010765)3.33464082
22Pterygium (HP:0001059)3.33052712
23Alopecia of scalp (HP:0002293)3.19510299
24Sparse scalp hair (HP:0002209)3.15600625
25Insomnia (HP:0100785)3.01343235
26Abnormal blistering of the skin (HP:0008066)2.99452973
27Hypoplasia of dental enamel (HP:0006297)2.98571519
28Ridged nail (HP:0001807)2.96755275
29Selective tooth agenesis (HP:0001592)2.91611570
30Erythema (HP:0010783)2.90653335
31Thick nail (HP:0001805)2.89862741
32Brittle hair (HP:0002299)2.78539456
33Ankyloglossia (HP:0010296)2.73836974
34Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.69271631
35Absent epiphyses (HP:0010577)2.69271631
36Hyperacusis (HP:0010780)2.66767072
37Slow-growing hair (HP:0002217)2.64107745
38Abnormality of hair growth rate (HP:0011363)2.64107745
39Lip pit (HP:0100267)2.60373481
40Distal lower limb amyotrophy (HP:0008944)2.49897281
41Focal segmental glomerulosclerosis (HP:0000097)2.49593399
42Oligodontia (HP:0000677)2.46587868
43Abnormality of the gastric mucosa (HP:0004295)2.40963356
44Fragile skin (HP:0001030)2.40834029
45Hypoplasia of the capital femoral epiphysis (HP:0003090)2.39855907
46Amelogenesis imperfecta (HP:0000705)2.39524433
47Trismus (HP:0000211)2.38675207
48Congenital ichthyosiform erythroderma (HP:0007431)2.36840180
49Fatigable weakness (HP:0003473)2.34963782
50Abnormality of the neuromuscular junction (HP:0003398)2.34963782
51Adrenal hypoplasia (HP:0000835)2.31278810
52Advanced eruption of teeth (HP:0006288)2.27729006
53Glomerulosclerosis (HP:0000096)2.27317134
54Abnormality of oral frenula (HP:0000190)2.26100623
55Natal tooth (HP:0000695)2.17266582
56Squamous cell carcinoma (HP:0002860)2.14713128
57Oral leukoplakia (HP:0002745)2.10565642
58Short nail (HP:0001799)2.08749162
59Malignant hyperthermia (HP:0002047)2.04081399
60Carious teeth (HP:0000670)2.03783534
61Broad face (HP:0000283)2.02960168
62Cervical subluxation (HP:0003308)1.98333567
63Hypodontia (HP:0000668)1.97861960
64Septate vagina (HP:0001153)1.88541637
65Weak cry (HP:0001612)1.86571726
66Palmoplantar keratoderma (HP:0000982)1.86354140
67Abnormalities of placenta or umbilical cord (HP:0001194)1.85605423
68Anonychia (HP:0001798)1.81124768
69Poikiloderma (HP:0001029)1.80464779
70Premature loss of primary teeth (HP:0006323)1.78541681
71Cone-rod dystrophy (HP:0000548)1.76186687
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.72843144
73Ectropion (HP:0000656)1.71102100
74Elfin facies (HP:0004428)1.70339931
75Entropion (HP:0000621)1.70265005
76Dehydration (HP:0001944)1.70005587
77Horizontal nystagmus (HP:0000666)1.67106667
78Abnormality of the distal phalanges of the toes (HP:0010182)1.66479382
79Overriding aorta (HP:0002623)1.65948299
80Sudden death (HP:0001699)1.65078132
81Fine hair (HP:0002213)1.64622751
82Curly hair (HP:0002212)1.63804950
83Microdontia (HP:0000691)1.62307251
84Hypokinesia (HP:0002375)1.58955152
85Lower limb amyotrophy (HP:0007210)1.58775056
86Dry hair (HP:0011359)1.58764840
87Esophageal atresia (HP:0002032)1.54520721
88Abnormality of the salivary glands (HP:0010286)1.51657124
89Corneal erosion (HP:0200020)1.50948600
90Exercise-induced myalgia (HP:0003738)1.50846813
91Hyperhidrosis (HP:0000975)1.50429983
92Abnormality of the fingernails (HP:0001231)1.50276231
93Upper limb amyotrophy (HP:0009129)1.49645686
94Distal upper limb amyotrophy (HP:0007149)1.49645686
95Ventricular tachycardia (HP:0004756)1.48381190
96Disproportionate short-trunk short stature (HP:0003521)1.47937587
97Short clavicles (HP:0000894)1.46658468
98Death in infancy (HP:0001522)1.46507585
99Deviation of the thumb (HP:0009603)1.46385508
100Flat acetabular roof (HP:0003180)1.44868143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA28.72106210
2MST1R5.63659536
3PDK24.85605996
4MST43.77541497
5LMTK22.81133907
6MET2.70186149
7LATS22.45727854
8ARAF2.25658428
9MAP3K92.23454594
10NME22.09912153
11NEK61.88604863
12SIK11.87623169
13LATS11.86399077
14MAP3K21.72539728
15EIF2AK11.72201815
16PBK1.68678329
17STK241.57999169
18EPHB21.55844427
19STK38L1.55412773
20EIF2AK31.34321504
21MAP3K31.33675861
22FER1.31007152
23PTK21.28243294
24IRAK31.19631747
25STK381.19186143
26MAP3K121.17658962
27PRKCI1.17510998
28PAK41.16573736
29CDK81.09312834
30KSR21.01654540
31SCYL20.98311045
32PHKG20.96472684
33PHKG10.96472684
34RPS6KA40.89431856
35SRPK10.87494763
36EEF2K0.81100749
37LRRK20.75954561
38MUSK0.74194193
39STK100.71149416
40PIM20.67399948
41BRAF0.65824471
42STK30.64805692
43KSR10.61978768
44NME10.61022094
45ERBB30.60505424
46TRPM70.60403486
47PTK60.58936923
48PDGFRB0.58720308
49ILK0.58331093
50CSNK1G10.57718785
51TRIB30.57350134
52TESK20.51315491
53CDK70.50525819
54MAP3K80.50320077
55MAP3K130.49916438
56TTK0.49366137
57CHEK20.49012561
58BUB10.48249024
59CSNK1A1L0.47289753
60MAP2K60.46786732
61SMG10.46311476
62ABL20.45869880
63ERBB40.45527034
64CSNK1G30.44475837
65ERBB20.44351712
66PRKG20.43924363
67BRD40.42971120
68DDR20.42302453
69RAF10.41480188
70MELK0.39197252
71STK160.38023172
72CAMK2G0.37516588
73NEK10.36871872
74ICK0.36192055
75NTRK10.32619259
76GRK10.31920149
77CCNB10.31441159
78RPS6KB20.30942199
79EPHB10.29010801
80BMX0.28404762
81AURKB0.27664710
82MAP2K10.27146590
83STK390.26068827
84MTOR0.25676362
85ROCK20.25072152
86PLK10.24523167
87ADRBK10.23931739
88EIF2AK20.23381326
89CDK120.21366124
90ROCK10.20760679
91CSNK1G20.20721840
92PTK2B0.20454705
93TSSK60.19599844
94PKN20.18346598
95MAPK150.18327574
96EGFR0.17902477
97GSK3A0.16684207
98CSNK1E0.15289899
99NEK20.14953908
100CSNK1A10.14633784

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.04540653
2Fatty acid biosynthesis_Homo sapiens_hsa000613.45780576
3Caffeine metabolism_Homo sapiens_hsa002323.21199719
4ECM-receptor interaction_Homo sapiens_hsa045122.94647127
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.65318397
6Fatty acid elongation_Homo sapiens_hsa000622.63352232
7Vibrio cholerae infection_Homo sapiens_hsa051102.38766817
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36334900
9Steroid biosynthesis_Homo sapiens_hsa001002.26611487
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18442975
11Hippo signaling pathway_Homo sapiens_hsa043902.02140456
12Small cell lung cancer_Homo sapiens_hsa052221.88668299
13N-Glycan biosynthesis_Homo sapiens_hsa005101.78656456
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.55567857
15Bladder cancer_Homo sapiens_hsa052191.50537672
16Basal transcription factors_Homo sapiens_hsa030221.46271950
17Thyroid cancer_Homo sapiens_hsa052161.45123482
18Tight junction_Homo sapiens_hsa045301.44143778
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37296779
20Collecting duct acid secretion_Homo sapiens_hsa049661.35518439
21Adherens junction_Homo sapiens_hsa045201.34210353
22Sphingolipid metabolism_Homo sapiens_hsa006001.34136893
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30719557
24Focal adhesion_Homo sapiens_hsa045101.29350702
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28197084
26Galactose metabolism_Homo sapiens_hsa000521.27737584
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26770292
28Basal cell carcinoma_Homo sapiens_hsa052171.24942851
29Notch signaling pathway_Homo sapiens_hsa043301.24936187
30p53 signaling pathway_Homo sapiens_hsa041151.22290234
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22051507
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20202034
33Endometrial cancer_Homo sapiens_hsa052131.17869219
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17445710
35Cell cycle_Homo sapiens_hsa041101.09747415
36Dilated cardiomyopathy_Homo sapiens_hsa054141.05305809
37Proteoglycans in cancer_Homo sapiens_hsa052051.01411040
38Mismatch repair_Homo sapiens_hsa034300.97621113
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95305581
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95173298
41Pyruvate metabolism_Homo sapiens_hsa006200.94762511
42Fatty acid metabolism_Homo sapiens_hsa012120.90434159
43Bile secretion_Homo sapiens_hsa049760.88309081
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82836819
45Axon guidance_Homo sapiens_hsa043600.82631843
46Propanoate metabolism_Homo sapiens_hsa006400.80740352
47Melanoma_Homo sapiens_hsa052180.79895684
48Other glycan degradation_Homo sapiens_hsa005110.78231026
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77058178
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75387878
51Ribosome_Homo sapiens_hsa030100.74320658
52Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69715895
53Sulfur metabolism_Homo sapiens_hsa009200.69143008
54Lysine degradation_Homo sapiens_hsa003100.66143015
55Folate biosynthesis_Homo sapiens_hsa007900.65140913
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64990406
57MicroRNAs in cancer_Homo sapiens_hsa052060.64826318
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.64546022
59TGF-beta signaling pathway_Homo sapiens_hsa043500.63750728
60Oocyte meiosis_Homo sapiens_hsa041140.62447673
61One carbon pool by folate_Homo sapiens_hsa006700.59242053
62ErbB signaling pathway_Homo sapiens_hsa040120.57978417
63Nucleotide excision repair_Homo sapiens_hsa034200.57973159
64RNA transport_Homo sapiens_hsa030130.56697272
65Homologous recombination_Homo sapiens_hsa034400.54541708
66RNA polymerase_Homo sapiens_hsa030200.53760628
67Pathways in cancer_Homo sapiens_hsa052000.51367932
68Glioma_Homo sapiens_hsa052140.51259299
69Apoptosis_Homo sapiens_hsa042100.50937332
70Chronic myeloid leukemia_Homo sapiens_hsa052200.50741133
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50675351
72Pancreatic cancer_Homo sapiens_hsa052120.48379260
73Protein digestion and absorption_Homo sapiens_hsa049740.47642356
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47276283
75Carbon metabolism_Homo sapiens_hsa012000.46782090
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.45715293
77Wnt signaling pathway_Homo sapiens_hsa043100.45662602
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.43759823
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.43216726
80Peroxisome_Homo sapiens_hsa041460.41520189
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39557293
82PPAR signaling pathway_Homo sapiens_hsa033200.39031950
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.38889692
84Biosynthesis of amino acids_Homo sapiens_hsa012300.37766281
85Starch and sucrose metabolism_Homo sapiens_hsa005000.36743071
86Colorectal cancer_Homo sapiens_hsa052100.36727575
87Pentose phosphate pathway_Homo sapiens_hsa000300.36336711
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36048164
89Glycerolipid metabolism_Homo sapiens_hsa005610.35826260
90Viral carcinogenesis_Homo sapiens_hsa052030.35370750
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.35172725
92Metabolic pathways_Homo sapiens_hsa011000.34062895
93Pyrimidine metabolism_Homo sapiens_hsa002400.31378523
94Arginine biosynthesis_Homo sapiens_hsa002200.30486241
95mRNA surveillance pathway_Homo sapiens_hsa030150.30483525
96Renal cell carcinoma_Homo sapiens_hsa052110.28824175
97Amoebiasis_Homo sapiens_hsa051460.28642605
98Oxidative phosphorylation_Homo sapiens_hsa001900.28631531
99Non-small cell lung cancer_Homo sapiens_hsa052230.27784730
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25820961

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