ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.78821233
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.33809953
3	fucose catabolic process (GO:0019317)	4.28041947
4	L-fucose metabolic process (GO:0042354)	4.28041947
5	L-fucose catabolic process (GO:0042355)	4.28041947
6	response to pheromone (GO:0019236)	4.19392951
7	neural tube formation (GO:0001841)	3.95259430
8	epithelial cilium movement (GO:0003351)	3.88956663
9	protein K11-linked deubiquitination (GO:0035871)	3.78024930
10	DNA double-strand break processing (GO:0000729)	3.77949293
11	multicellular organism reproduction (GO:0032504)	3.74762663
12	platelet dense granule organization (GO:0060155)	3.74561335
13	sperm motility (GO:0030317)	3.71807591
14	rRNA catabolic process (GO:0016075)	3.68930871
15	protein polyglutamylation (GO:0018095)	3.65658264
16	cellular ketone body metabolic process (GO:0046950)	3.64028100
17	regulation of cilium movement (GO:0003352)	3.63723355
18	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.52714684
19	acrosome reaction (GO:0007340)	3.49619473
20	axoneme assembly (GO:0035082)	3.38258078
21	centriole replication (GO:0007099)	3.37478777
22	DNA deamination (GO:0045006)	3.33156271
23	ketone body metabolic process (GO:1902224)	3.32767708
24	organic cation transport (GO:0015695)	3.26671281
25	water-soluble vitamin biosynthetic process (GO:0042364)	3.21424620
26	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.19492518
27	cilium movement (GO:0003341)	3.11747238
28	indolalkylamine metabolic process (GO:0006586)	3.09012630
29	establishment of protein localization to Golgi (GO:0072600)	3.07658827
30	respiratory chain complex IV assembly (GO:0008535)	3.06738890
31	indole-containing compound catabolic process (GO:0042436)	3.04829817
32	indolalkylamine catabolic process (GO:0046218)	3.04829817
33	tryptophan catabolic process (GO:0006569)	3.04829817
34	regulation of action potential (GO:0098900)	3.02486624
35	mannosylation (GO:0097502)	2.97655522
36	cilium morphogenesis (GO:0060271)	2.96779050
37	detection of light stimulus involved in sensory perception (GO:0050962)	2.96699898
38	detection of light stimulus involved in visual perception (GO:0050908)	2.96699898
39	intraciliary transport (GO:0042073)	2.90655740
40	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.90578731
41	piRNA metabolic process (GO:0034587)	2.90074525
42	DNA methylation involved in gamete generation (GO:0043046)	2.88137394
43	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.86908617
44	protein targeting to Golgi (GO:0000042)	2.85944963
45	synapsis (GO:0007129)	2.85770163
46	cilium organization (GO:0044782)	2.85293732
47	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.83274042
48	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.83274042
49	regulation of translation, ncRNA-mediated (GO:0045974)	2.83274042
50	somite development (GO:0061053)	2.83063848
51	fusion of sperm to egg plasma membrane (GO:0007342)	2.80566122
52	retinal cone cell development (GO:0046549)	2.79695260
53	cilium assembly (GO:0042384)	2.78694422
54	protein-cofactor linkage (GO:0018065)	2.76235699
55	cell wall macromolecule catabolic process (GO:0016998)	2.73895273
56	protein complex biogenesis (GO:0070271)	2.73490062
57	tryptophan metabolic process (GO:0006568)	2.73375663
58	embryonic epithelial tube formation (GO:0001838)	2.72900160
59	sperm-egg recognition (GO:0035036)	2.72121556
60	male meiosis I (GO:0007141)	2.72020928
61	replication fork processing (GO:0031297)	2.70867129
62	cornea development in camera-type eye (GO:0061303)	2.70712811
63	protein K6-linked ubiquitination (GO:0085020)	2.67561551
64	dopamine transport (GO:0015872)	2.67413903
65	photoreceptor cell maintenance (GO:0045494)	2.67278133
66	recombinational repair (GO:0000725)	2.65276289
67	cytochrome complex assembly (GO:0017004)	2.65197355
68	double-strand break repair via homologous recombination (GO:0000724)	2.63049948
69	protein localization to Golgi apparatus (GO:0034067)	2.62698295
70	male meiosis (GO:0007140)	2.61489216
71	regulation of hexokinase activity (GO:1903299)	2.60932679
72	regulation of glucokinase activity (GO:0033131)	2.60932679
73	nonmotile primary cilium assembly (GO:0035058)	2.58553573
74	kynurenine metabolic process (GO:0070189)	2.58188535
75	spermatid development (GO:0007286)	2.58000352
76	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.57140583
77	NADH dehydrogenase complex assembly (GO:0010257)	2.57140583
78	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.57140583
79	reflex (GO:0060004)	2.55779194
80	nephron tubule morphogenesis (GO:0072078)	2.55300344
81	nephron epithelium morphogenesis (GO:0072088)	2.55300344
82	cilium or flagellum-dependent cell motility (GO:0001539)	2.54875585
83	cell wall macromolecule metabolic process (GO:0044036)	2.54566287
84	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.53920089
85	protein localization to cilium (GO:0061512)	2.53802535
86	mitochondrial respiratory chain complex assembly (GO:0033108)	2.53571887
87	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.52920467
88	left/right axis specification (GO:0070986)	2.52187978
89	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.51577960
90	negative regulation of telomere maintenance (GO:0032205)	2.49409966
91	epithelial tube formation (GO:0072175)	2.49105020
92	reciprocal DNA recombination (GO:0035825)	2.48916464
93	reciprocal meiotic recombination (GO:0007131)	2.48916464
94	somite rostral/caudal axis specification (GO:0032525)	2.47313085
95	resolution of meiotic recombination intermediates (GO:0000712)	2.47007958
96	proteasome assembly (GO:0043248)	2.46998809
97	amine catabolic process (GO:0009310)	2.45327664
98	cellular biogenic amine catabolic process (GO:0042402)	2.45327664
99	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.44841604
100	photoreceptor cell development (GO:0042461)	2.43933367

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.87470804
2	VDR_22108803_ChIP-Seq_LS180_Human	3.00868350
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.70069572
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.64291291
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.61820161
6	FUS_26573619_Chip-Seq_HEK293_Human	2.58576190
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.55684530
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.47535778
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.43913053
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.34914052
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.24447956
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21540077
13	P300_19829295_ChIP-Seq_ESCs_Human	2.15078627
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.10559695
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.06573099
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.96417793
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96025522
18	EZH2_22144423_ChIP-Seq_EOC_Human	1.95848320
19	EWS_26573619_Chip-Seq_HEK293_Human	1.94983722
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.90638384
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.83820545
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.83014752
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.82439631
24	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79914932
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.79844917
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.76107834
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.73091084
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.70149983
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.70149983
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.66270692
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.54636421
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54636421
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.52645479
34	AR_25329375_ChIP-Seq_VCAP_Human	1.52544673
35	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.52257530
36	STAT3_23295773_ChIP-Seq_U87_Human	1.50813429
37	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.50542718
38	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.47157942
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.46264307
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.46264307
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45604217
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.45458867
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.45195571
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45165668
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45165668
46	TCF4_23295773_ChIP-Seq_U87_Human	1.45011699
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.43708308
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.42439561
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41788226
50	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41767805
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.39659887
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.38457769
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33593081
54	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33097168
55	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31951003
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31532774
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31325133
58	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31185288
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30473890
60	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.29570092
61	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.29334925
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.28993484
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27778669
64	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.25984005
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25507326
66	AR_20517297_ChIP-Seq_VCAP_Human	1.22359744
67	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.21403269
68	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.20841101
69	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.19639731
70	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.19447976
71	* NCOR_22424771_ChIP-Seq_293T_Human	1.19002843
72	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18159608
73	ELK1_19687146_ChIP-ChIP_HELA_Human	1.18023450
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17616611
75	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17040991
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16881377
77	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16779086
78	MYC_18940864_ChIP-ChIP_HL60_Human	1.16736750
79	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.16086667
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15949277
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.11811027
82	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11678769
83	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11322454
84	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10485831
85	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09821766
86	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09520451
87	CDX2_22108803_ChIP-Seq_LS180_Human	1.09139313
88	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.08786025
89	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08561881
90	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08153895
91	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07303449
92	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.06797370
93	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.06289903
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.06171520
95	P300_18555785_Chip-Seq_ESCs_Mouse	1.04424098
96	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04157068
97	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03854177
98	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03078453
99	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.01238326
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.01041935

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.00021700
2	MP0000372_irregular_coat_pigmentation	2.84281873
3	MP0003787_abnormal_imprinting	2.55209207
4	MP0003195_calcinosis	2.53305585
5	MP0002102_abnormal_ear_morphology	2.50310464
6	MP0006292_abnormal_olfactory_placode	2.46587914
7	MP0005410_abnormal_fertilization	2.36152002
8	MP0002638_abnormal_pupillary_reflex	2.26859387
9	MP0005551_abnormal_eye_electrophysiolog	2.21614487
10	MP0005646_abnormal_pituitary_gland	2.08695657
11	MP0003646_muscle_fatigue	2.05420775
12	MP0001968_abnormal_touch/_nociception	2.04006201
13	MP0005645_abnormal_hypothalamus_physiol	2.01298335
14	MP0003136_yellow_coat_color	1.97956387
15	MP0005253_abnormal_eye_physiology	1.89105697
16	MP0002837_dystrophic_cardiac_calcinosis	1.86456621
17	MP0004147_increased_porphyrin_level	1.77408796
18	MP0002736_abnormal_nociception_after	1.76614641
19	MP0008872_abnormal_physiological_respon	1.76353434
20	MP0006072_abnormal_retinal_apoptosis	1.69508798
21	MP0006276_abnormal_autonomic_nervous	1.68752661
22	MP0002234_abnormal_pharynx_morphology	1.67897773
23	MP0001486_abnormal_startle_reflex	1.65450344
24	MP0001485_abnormal_pinna_reflex	1.63994964
25	MP0002876_abnormal_thyroid_physiology	1.59546630
26	MP0001986_abnormal_taste_sensitivity	1.57833909
27	MP0004145_abnormal_muscle_electrophysio	1.54056880
28	MP0003880_abnormal_central_pattern	1.53789478
29	MP0003878_abnormal_ear_physiology	1.53682213
30	MP0005377_hearing/vestibular/ear_phenot	1.53682213
31	MP0000569_abnormal_digit_pigmentation	1.53213938
32	MP0010386_abnormal_urinary_bladder	1.52991915
33	MP0000383_abnormal_hair_follicle	1.51675908
34	MP0004142_abnormal_muscle_tone	1.50246527
35	MP0001529_abnormal_vocalization	1.49686702
36	MP0005084_abnormal_gallbladder_morpholo	1.48645748
37	MP0002138_abnormal_hepatobiliary_system	1.48234516
38	MP0002938_white_spotting	1.47807933
39	MP0003121_genomic_imprinting	1.47103328
40	MP0002163_abnormal_gland_morphology	1.39431850
41	MP0000427_abnormal_hair_cycle	1.38167539
42	MP0002735_abnormal_chemical_nociception	1.37796291
43	MP0008995_early_reproductive_senescence	1.36771659
44	MP0004885_abnormal_endolymph	1.35081789
45	MP0009745_abnormal_behavioral_response	1.34197391
46	MP0005379_endocrine/exocrine_gland_phen	1.33957839
47	MP0003011_delayed_dark_adaptation	1.33718805
48	MP0001984_abnormal_olfaction	1.30233783
49	MP0003698_abnormal_male_reproductive	1.29564773
50	MP0009046_muscle_twitch	1.26150768
51	MP0001929_abnormal_gametogenesis	1.24915880
52	MP0008875_abnormal_xenobiotic_pharmacok	1.22764976
53	MP0002160_abnormal_reproductive_system	1.21401596
54	MP0002095_abnormal_skin_pigmentation	1.20315841
55	MP0000631_abnormal_neuroendocrine_gland	1.20100629
56	MP0002272_abnormal_nervous_system	1.18725251
57	MP0004484_altered_response_of	1.17209322
58	MP0005075_abnormal_melanosome_morpholog	1.14582230
59	MP0003950_abnormal_plasma_membrane	1.13672127
60	MP0003252_abnormal_bile_duct	1.12625002
61	MP0005389_reproductive_system_phenotype	1.11029322
62	MP0003718_maternal_effect	1.09026646
63	MP0008789_abnormal_olfactory_epithelium	1.08867439
64	MP0005670_abnormal_white_adipose	1.07876936
65	MP0001293_anophthalmia	1.04899617
66	MP0002928_abnormal_bile_duct	1.03846586
67	MP0001501_abnormal_sleep_pattern	1.01593860
68	MP0005174_abnormal_tail_pigmentation	0.99725629
69	MP0002132_abnormal_respiratory_system	0.99680595
70	MP0001970_abnormal_pain_threshold	0.99657674
71	MP0004215_abnormal_myocardial_fiber	0.99119974
72	MP0002733_abnormal_thermal_nociception	0.99074107
73	MP0004133_heterotaxia	0.96380254
74	MP0003137_abnormal_impulse_conducting	0.93781064
75	MP0005083_abnormal_biliary_tract	0.93008309
76	MP0003786_premature_aging	0.92786030
77	MP0000647_abnormal_sebaceous_gland	0.92710276
78	MP0002653_abnormal_ependyma_morphology	0.91460767
79	MP0008058_abnormal_DNA_repair	0.90436171
80	MP0001963_abnormal_hearing_physiology	0.89493080
81	MP0002067_abnormal_sensory_capabilities	0.89086692
82	MP0001502_abnormal_circadian_rhythm	0.88349821
83	MP0005195_abnormal_posterior_eye	0.88101119
84	MP0002557_abnormal_social/conspecific_i	0.86806161
85	MP0005171_absent_coat_pigmentation	0.85429426
86	MP0002229_neurodegeneration	0.84977074
87	MP0002210_abnormal_sex_determination	0.84306557
88	MP0002751_abnormal_autonomic_nervous	0.82737392
89	MP0000230_abnormal_systemic_arterial	0.82652443
90	MP0001764_abnormal_homeostasis	0.82419799
91	MP0002752_abnormal_somatic_nervous	0.79932767
92	MP0003283_abnormal_digestive_organ	0.79893763
93	MP0000026_abnormal_inner_ear	0.79569374
94	MP0005391_vision/eye_phenotype	0.79535573
95	MP0008775_abnormal_heart_ventricle	0.79466729
96	MP0000653_abnormal_sex_gland	0.78613591
97	MP0002572_abnormal_emotion/affect_behav	0.78332627
98	MP0001145_abnormal_male_reproductive	0.77913019
99	MP0002282_abnormal_trachea_morphology	0.76675958
100	MP0004742_abnormal_vestibular_system	0.76169364

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.40198989
2	Abnormality of midbrain morphology (HP:0002418)	4.37155698
3	Molar tooth sign on MRI (HP:0002419)	4.37155698
4	Pancreatic fibrosis (HP:0100732)	3.86799846
5	True hermaphroditism (HP:0010459)	3.80677870
6	Nephronophthisis (HP:0000090)	3.73750256
7	Congenital stationary night blindness (HP:0007642)	3.50845603
8	Chronic hepatic failure (HP:0100626)	3.32237824
9	Abnormality of the renal medulla (HP:0100957)	3.24181311
10	Attenuation of retinal blood vessels (HP:0007843)	3.03377857
11	Abnormal rod and cone electroretinograms (HP:0008323)	2.99668688
12	Abnormality of the renal cortex (HP:0011035)	2.96891643
13	Stomach cancer (HP:0012126)	2.92044143
14	Medial flaring of the eyebrow (HP:0010747)	2.91807461
15	Type II lissencephaly (HP:0007260)	2.89890637
16	Intestinal atresia (HP:0011100)	2.64477338
17	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.62960233
18	Absent/shortened dynein arms (HP:0200106)	2.62960233
19	Tubular atrophy (HP:0000092)	2.62780844
20	Cystic liver disease (HP:0006706)	2.58980470
21	Gaze-evoked nystagmus (HP:0000640)	2.55946215
22	Pendular nystagmus (HP:0012043)	2.53983392
23	Abnormality of macular pigmentation (HP:0008002)	2.48538911
24	Oligodactyly (hands) (HP:0001180)	2.48295636
25	Abolished electroretinogram (ERG) (HP:0000550)	2.43387427
26	Cerebellar dysplasia (HP:0007033)	2.38063203
27	Severe visual impairment (HP:0001141)	2.37712140
28	3-Methylglutaconic aciduria (HP:0003535)	2.36519557
29	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.32822241
30	Abnormality of alanine metabolism (HP:0010916)	2.32822241
31	Hyperalaninemia (HP:0003348)	2.32822241
32	Hypoproteinemia (HP:0003075)	2.32243737
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.30944516
34	Anencephaly (HP:0002323)	2.29528055
35	Decreased central vision (HP:0007663)	2.27573525
36	Abnormal drinking behavior (HP:0030082)	2.26349575
37	Polydipsia (HP:0001959)	2.26349575
38	Congenital primary aphakia (HP:0007707)	2.23831013
39	Bony spicule pigmentary retinopathy (HP:0007737)	2.23728713
40	Abnormal respiratory motile cilium morphology (HP:0005938)	2.20646804
41	Abnormal respiratory epithelium morphology (HP:0012253)	2.20646804
42	Congenital hepatic fibrosis (HP:0002612)	2.19915658
43	Gait imbalance (HP:0002141)	2.19362259
44	Broad-based gait (HP:0002136)	2.11738544
45	Concave nail (HP:0001598)	2.11568846
46	Large for gestational age (HP:0001520)	2.11284007
47	Genetic anticipation (HP:0003743)	2.11043566
48	Keratoconus (HP:0000563)	2.10994637
49	Increased corneal curvature (HP:0100692)	2.10994637
50	Hyperventilation (HP:0002883)	2.09338968
51	Sclerocornea (HP:0000647)	2.08571916
52	Postaxial foot polydactyly (HP:0001830)	2.08435353
53	Abnormality of B cell number (HP:0010975)	2.06596872
54	Progressive cerebellar ataxia (HP:0002073)	2.05937970
55	Hypoplasia of the fovea (HP:0007750)	2.04787852
56	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.04787852
57	Genital tract atresia (HP:0001827)	2.04294394
58	Abnormality of the labia minora (HP:0012880)	2.03617921
59	Hypothermia (HP:0002045)	2.03509445
60	Renal cortical cysts (HP:0000803)	2.02736909
61	Febrile seizures (HP:0002373)	2.01528072
62	Polyuria (HP:0000103)	2.00428233
63	Hyperglycinemia (HP:0002154)	2.00394523
64	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.99242424
65	Nephrogenic diabetes insipidus (HP:0009806)	1.98686863
66	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.95759863
67	Vaginal atresia (HP:0000148)	1.94877642
68	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.93883174
69	Abnormal ciliary motility (HP:0012262)	1.93259330
70	Inability to walk (HP:0002540)	1.92742271
71	Dandy-Walker malformation (HP:0001305)	1.89277832
72	Abnormality of the renal collecting system (HP:0004742)	1.85395568
73	Increased CSF lactate (HP:0002490)	1.85209101
74	Methylmalonic acidemia (HP:0002912)	1.84668686
75	Median cleft lip (HP:0000161)	1.84468257
76	Thyroiditis (HP:0100646)	1.84398240
77	Male pseudohermaphroditism (HP:0000037)	1.84015616
78	Mitochondrial inheritance (HP:0001427)	1.84010889
79	Postaxial hand polydactyly (HP:0001162)	1.83570267
80	Furrowed tongue (HP:0000221)	1.83433532
81	Optic disc pallor (HP:0000543)	1.82510201
82	Acute necrotizing encephalopathy (HP:0006965)	1.82409457
83	Lissencephaly (HP:0001339)	1.81377711
84	Abnormality of the pons (HP:0007361)	1.79315957
85	Constricted visual fields (HP:0001133)	1.75144855
86	Progressive macrocephaly (HP:0004481)	1.75091602
87	Small hand (HP:0200055)	1.74963956
88	Volvulus (HP:0002580)	1.74721064
89	Abnormality of the fovea (HP:0000493)	1.74600829
90	Stomatitis (HP:0010280)	1.73862644
91	Abnormal hemoglobin (HP:0011902)	1.70387839
92	Abnormality of the ileum (HP:0001549)	1.69518784
93	Oculomotor apraxia (HP:0000657)	1.69120127
94	Neonatal respiratory distress (HP:0002643)	1.68074076
95	Occipital encephalocele (HP:0002085)	1.67943344
96	Sloping forehead (HP:0000340)	1.67484141
97	Retinal dysplasia (HP:0007973)	1.67389149
98	Preaxial hand polydactyly (HP:0001177)	1.66777252
99	Astigmatism (HP:0000483)	1.65724309
100	Abnormal respiratory motile cilium physiology (HP:0012261)	1.65415459

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.89223541
2	BMPR1B	3.17400156
3	MAP4K2	2.88504160
4	ZAK	2.86903766
5	NUAK1	2.72715970
6	ADRBK2	2.65818117
7	GRK1	2.51711747
8	MAP3K4	2.49034580
9	TAOK3	2.42023434
10	PINK1	2.35846515
11	WNK3	2.10464630
12	PLK4	2.01635483
13	MKNK2	1.94551550
14	ACVR1B	1.84050625
15	TLK1	1.83499238
16	TXK	1.78829761
17	OXSR1	1.68097696
18	MAP2K7	1.60023247
19	STK39	1.52084043
20	INSRR	1.48106218
21	MAPK13	1.46422081
22	WNK4	1.37207216
23	BRSK2	1.37017718
24	CASK	1.30550525
25	PLK2	1.29006505
26	EPHA4	1.28751703
27	TEC	1.19345302
28	CAMKK2	1.11106635
29	MKNK1	1.08893485
30	TRIM28	1.08382823
31	TAF1	1.06292033
32	PAK3	1.05098773
33	STK38L	1.04427157
34	TNIK	1.03120154
35	VRK1	1.01155290
36	OBSCN	1.00452100
37	TGFBR1	0.97009492
38	PRKCE	0.95132926
39	TIE1	0.92776868
40	EIF2AK3	0.91875549
41	NTRK3	0.91040244
42	ADRBK1	0.88418594
43	BCR	0.85276162
44	CSNK1G1	0.85174317
45	ERBB3	0.85033718
46	PBK	0.83446929
47	MAP2K6	0.80570485
48	FGFR2	0.76736060
49	PHKG1	0.71263233
50	PHKG2	0.71263233
51	PLK3	0.70349848
52	AKT3	0.69546045
53	CSNK1G3	0.68652821
54	TNK2	0.68470349
55	PRKCG	0.67297638
56	DYRK2	0.67137377
57	DAPK2	0.67121635
58	CSNK1G2	0.64069641
59	BCKDK	0.63920714
60	PRKCQ	0.63729104
61	CSNK1A1L	0.62374350
62	MUSK	0.62040999
63	PTK2B	0.61548281
64	CAMK1G	0.61262612
65	BMPR2	0.60665185
66	WEE1	0.59328044
67	CAMK1D	0.55878646
68	KIT	0.55446589
69	PNCK	0.53148189
70	PLK1	0.52849206
71	GRK7	0.52150851
72	MST4	0.51692569
73	MAP2K4	0.51630350
74	IKBKB	0.48936418
75	ITK	0.48639396
76	PRKG1	0.47315333
77	EIF2AK2	0.47087367
78	SGK2	0.46527870
79	CSNK1D	0.46357381
80	PKN1	0.45319794
81	PIK3CA	0.43741660
82	MARK3	0.42803980
83	PIK3CG	0.42553773
84	MARK1	0.42523741
85	ATR	0.40477680
86	CHEK2	0.39333328
87	STK3	0.39187203
88	SYK	0.39069021
89	PRKACA	0.39001310
90	NLK	0.38843331
91	ATM	0.37845038
92	CAMK1	0.34910293
93	CSNK1A1	0.34150958
94	CDK19	0.33518181
95	GRK5	0.33302407
96	CDK3	0.33026885
97	CAMK2A	0.32731290
98	EIF2AK1	0.31885994
99	RPS6KA5	0.31813891
100	FLT3	0.30724692

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.98170883
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.72586054
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.61163791
4	Phototransduction_Homo sapiens_hsa04744	2.56538360
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.52630324
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.42570602
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.41951122
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.39419116
9	Butanoate metabolism_Homo sapiens_hsa00650	2.31242675
10	Propanoate metabolism_Homo sapiens_hsa00640	2.09541136
11	Caffeine metabolism_Homo sapiens_hsa00232	2.07195374
12	Oxidative phosphorylation_Homo sapiens_hsa00190	2.02664555
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.98341912
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.93519582
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.91361924
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.89166835
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.86991105
18	Homologous recombination_Homo sapiens_hsa03440	1.79282406
19	Basal transcription factors_Homo sapiens_hsa03022	1.77460284
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.76195655
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.72358907
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.67171597
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.64668631
24	Olfactory transduction_Homo sapiens_hsa04740	1.61875961
25	RNA degradation_Homo sapiens_hsa03018	1.61786361
26	Protein export_Homo sapiens_hsa03060	1.57074977
27	RNA polymerase_Homo sapiens_hsa03020	1.50672460
28	Peroxisome_Homo sapiens_hsa04146	1.40442649
29	Parkinsons disease_Homo sapiens_hsa05012	1.39708836
30	Nicotine addiction_Homo sapiens_hsa05033	1.33240012
31	Taste transduction_Homo sapiens_hsa04742	1.32765756
32	Retinol metabolism_Homo sapiens_hsa00830	1.22370314
33	One carbon pool by folate_Homo sapiens_hsa00670	1.19785194
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.18357713
35	Non-homologous end-joining_Homo sapiens_hsa03450	1.16163025
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.14164266
37	Proteasome_Homo sapiens_hsa03050	1.10899112
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10635765
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.05681640
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.02010860
41	Regulation of autophagy_Homo sapiens_hsa04140	0.99440605
42	Cardiac muscle contraction_Homo sapiens_hsa04260	0.97995079
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.96732603
44	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.95630689
45	Huntingtons disease_Homo sapiens_hsa05016	0.95564979
46	ABC transporters_Homo sapiens_hsa02010	0.93900897
47	Fat digestion and absorption_Homo sapiens_hsa04975	0.89260836
48	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.88093124
49	Fatty acid degradation_Homo sapiens_hsa00071	0.86104057
50	Purine metabolism_Homo sapiens_hsa00230	0.84933157
51	Graft-versus-host disease_Homo sapiens_hsa05332	0.84887894
52	Morphine addiction_Homo sapiens_hsa05032	0.84063693
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.82971648
54	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.82853090
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81892875
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81517636
57	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.79495118
58	Alzheimers disease_Homo sapiens_hsa05010	0.78671681
59	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77317801
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77180634
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.77010364
62	Salivary secretion_Homo sapiens_hsa04970	0.73766800
63	Mineral absorption_Homo sapiens_hsa04978	0.73528139
64	Primary immunodeficiency_Homo sapiens_hsa05340	0.72276479
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.71709083
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71441603
67	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.69254042
68	Circadian rhythm_Homo sapiens_hsa04710	0.68065000
69	Metabolic pathways_Homo sapiens_hsa01100	0.65099726
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.64970260
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62824778
72	Serotonergic synapse_Homo sapiens_hsa04726	0.62752912
73	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.61929845
74	Type I diabetes mellitus_Homo sapiens_hsa04940	0.60752441
75	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.60342141
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.59604661
77	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.56081551
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55479630
79	Circadian entrainment_Homo sapiens_hsa04713	0.54279697
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53685005
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.53403610
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52650186
83	Insulin secretion_Homo sapiens_hsa04911	0.51462325
84	Asthma_Homo sapiens_hsa05310	0.50704489
85	GABAergic synapse_Homo sapiens_hsa04727	0.49069450
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.48648060
87	RNA transport_Homo sapiens_hsa03013	0.45375370
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43230369
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.40943078
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40651204
91	Allograft rejection_Homo sapiens_hsa05330	0.40143960
92	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.40052538
93	Fatty acid elongation_Homo sapiens_hsa00062	0.39909150
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.39194614
95	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.37924514
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37015143
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36966583
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36952500
99	Base excision repair_Homo sapiens_hsa03410	0.35446281
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.34985916

C6ORF163

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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