ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	9.05493257
2	microtubule depolymerization (GO:0007019)	8.30622458
3	sperm capacitation (GO:0048240)	8.25181757
4	chromosome condensation (GO:0030261)	8.15321998
5	DNA packaging (GO:0006323)	8.11894354
6	single strand break repair (GO:0000012)	7.86386064
7	spermatid development (GO:0007286)	7.80920154
8	protein polyglutamylation (GO:0018095)	7.40995512
9	protein targeting to Golgi (GO:0000042)	7.32875317
10	microtubule polymerization or depolymerization (GO:0031109)	7.27236413
11	establishment of protein localization to Golgi (GO:0072600)	7.16922968
12	spermatid nucleus differentiation (GO:0007289)	6.98053874
13	plasma membrane fusion (GO:0045026)	6.87775226
14	rRNA methylation (GO:0031167)	6.74074103
15	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.73195542
16	regulation of cilium movement (GO:0003352)	6.71177227
17	sperm-egg recognition (GO:0035036)	6.53726211
18	negative regulation of inclusion body assembly (GO:0090084)	6.51862719
19	centriole replication (GO:0007099)	6.41467077
20	response to pheromone (GO:0019236)	6.28969391
21	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.13356716
22	multicellular organism reproduction (GO:0032504)	6.07836111
23	spermatogenesis (GO:0007283)	6.03361870
24	male gamete generation (GO:0048232)	6.01677997
25	binding of sperm to zona pellucida (GO:0007339)	5.93329353
26	axonemal dynein complex assembly (GO:0070286)	5.93165521
27	cilium or flagellum-dependent cell motility (GO:0001539)	5.78330467
28	phosphatidylethanolamine metabolic process (GO:0046337)	5.70334648
29	regulation of centriole replication (GO:0046599)	5.68915159
30	microtubule severing (GO:0051013)	5.67191628
31	reproduction (GO:0000003)	5.58688656
32	gamete generation (GO:0007276)	5.57573974
33	centriole assembly (GO:0098534)	5.52265909
34	rRNA modification (GO:0000154)	5.51968000
35	calcium ion-dependent exocytosis (GO:0017156)	5.37877686
36	seminiferous tubule development (GO:0072520)	5.35435021
37	protein localization to Golgi apparatus (GO:0034067)	5.34259325
38	cell-cell recognition (GO:0009988)	5.30023486
39	epithelial cilium movement (GO:0003351)	5.08657927
40	sexual reproduction (GO:0019953)	5.07778549
41	RNA destabilization (GO:0050779)	4.96679747
42	motile cilium assembly (GO:0044458)	4.91409866
43	germ cell development (GO:0007281)	4.60592334
44	single fertilization (GO:0007338)	4.60305868
45	cilium movement (GO:0003341)	4.58671535
46	piRNA metabolic process (GO:0034587)	4.55081144
47	regulation of inclusion body assembly (GO:0090083)	4.53000226
48	regulation of microtubule-based movement (GO:0060632)	4.52333105
49	multicellular organismal reproductive process (GO:0048609)	4.43203165
50	fertilization (GO:0009566)	4.42007861
51	cellular ketone body metabolic process (GO:0046950)	4.35928885
52	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.32943841
53	nucleus organization (GO:0006997)	4.21643417
54	DNA methylation involved in gamete generation (GO:0043046)	4.16163895
55	positive regulation of Rab GTPase activity (GO:0032851)	4.06649168
56	regulation of Rab GTPase activity (GO:0032313)	4.06649168
57	cell wall macromolecule catabolic process (GO:0016998)	4.02011027
58	ketone body metabolic process (GO:1902224)	3.89162994
59	microtubule nucleation (GO:0007020)	3.82242210
60	cell wall macromolecule metabolic process (GO:0044036)	3.80365576
61	male meiosis (GO:0007140)	3.80059163
62	male meiosis I (GO:0007141)	3.79337732
63	nuclear pore complex assembly (GO:0051292)	3.77010512
64	axoneme assembly (GO:0035082)	3.66009601
65	regulation of transcription involved in cell fate commitment (GO:0060850)	3.53549955
66	chromatin silencing (GO:0006342)	3.40939462
67	glomerular visceral epithelial cell development (GO:0072015)	3.34859196
68	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.31703312
69	musculoskeletal movement (GO:0050881)	3.28043399
70	multicellular organismal movement (GO:0050879)	3.28043399
71	glomerular epithelial cell development (GO:0072310)	3.16065469
72	organic cation transport (GO:0015695)	3.15821056
73	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.15347518
74	ventricular system development (GO:0021591)	3.11566462
75	mitochondrial fission (GO:0000266)	3.08429397
76	nucleosome disassembly (GO:0006337)	3.02942376
77	protein-DNA complex disassembly (GO:0032986)	3.02942376
78	histone exchange (GO:0043486)	2.99943671
79	microtubule bundle formation (GO:0001578)	2.99563128
80	cerebral cortex neuron differentiation (GO:0021895)	2.96846901
81	multicellular organismal development (GO:0007275)	2.96556730
82	RNA localization (GO:0006403)	2.96531877
83	cilium organization (GO:0044782)	2.96238906
84	intra-Golgi vesicle-mediated transport (GO:0006891)	2.95257818
85	protein depolymerization (GO:0051261)	2.94738456
86	meiosis I (GO:0007127)	2.94396102
87	centrosome duplication (GO:0051298)	2.93707582
88	glycerol ether metabolic process (GO:0006662)	2.92739272
89	cilium assembly (GO:0042384)	2.92166222
90	regulation of meiosis I (GO:0060631)	2.90555587
91	chromosome organization involved in meiosis (GO:0070192)	2.87306023
92	Golgi to endosome transport (GO:0006895)	2.86088840
93	nuclear pore organization (GO:0006999)	2.85626554
94	genitalia morphogenesis (GO:0035112)	2.83567781
95	DNA conformation change (GO:0071103)	2.83467688
96	homeostasis of number of cells within a tissue (GO:0048873)	2.82549645
97	synaptonemal complex assembly (GO:0007130)	2.81381897
98	polyamine biosynthetic process (GO:0006596)	2.81016179
99	sperm motility (GO:0030317)	11.2601689
100	acrosome reaction (GO:0007340)	10.3299895

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.57806900
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.11082253
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.02489768
4	FUS_26573619_Chip-Seq_HEK293_Human	2.81763634
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.74156195
6	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.54056344
7	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.54056344
8	CBP_20019798_ChIP-Seq_JUKART_Human	2.53248943
9	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.53248943
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.52246403
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.51191934
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.44725883
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.19192916
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.14951475
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.13732422
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.10906274
17	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.10218427
18	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	2.03160952
19	P300_19829295_ChIP-Seq_ESCs_Human	1.99883682
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.97006892
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.96522909
22	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.89645432
23	VDR_22108803_ChIP-Seq_LS180_Human	1.74876932
24	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.73343015
25	AR_25329375_ChIP-Seq_VCAP_Human	1.72430594
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67555186
27	STAT3_23295773_ChIP-Seq_U87_Human	1.67448778
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66419221
29	GBX2_23144817_ChIP-Seq_PC3_Human	1.64216850
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.63541571
31	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.62327872
32	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.60668612
33	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.60060279
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.55184986
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53848636
36	TP53_18474530_ChIP-ChIP_U2OS_Human	1.50957955
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.49973879
38	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.48785071
39	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.47386702
40	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.47333995
41	ETV1_20927104_ChIP-Seq_GIST48_Human	1.46890585
42	* ERA_21632823_ChIP-Seq_H3396_Human	1.46185887
43	RBPJ_21746931_ChIP-Seq_IB4_Human	1.43239163
44	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.41945138
45	DROSHA_22980978_ChIP-Seq_HELA_Human	1.41810434
46	MYC_19829295_ChIP-Seq_ESCs_Human	1.41203671
47	RUNX2_22187159_ChIP-Seq_PCA_Human	1.41017184
48	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.39917959
49	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.39767755
50	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.38863273
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36736092
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36736092
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35181201
54	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.34967616
55	TBL1_22424771_ChIP-Seq_293T_Human	1.34680324
56	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.33482262
57	NFYB_21822215_ChIP-Seq_K562_Human	1.33304908
58	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.32883799
59	ERG_20517297_ChIP-Seq_VCAP_Human	1.32664858
60	AR_21572438_ChIP-Seq_LNCaP_Human	1.26814378
61	PHF8_20622853_ChIP-Seq_HELA_Human	1.26761732
62	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.25112575
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24720772
64	OCT4_20526341_ChIP-Seq_ESCs_Human	1.23138521
65	* RAC3_21632823_ChIP-Seq_H3396_Human	1.22443371
66	TCF4_23295773_ChIP-Seq_U87_Human	1.22325458
67	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.21955187
68	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.21954303
69	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21034984
70	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.19893034
71	* TAF2_19829295_ChIP-Seq_ESCs_Human	1.18414423
72	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18214064
73	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.17757324
74	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.17539979
75	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.15137115
76	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14745111
77	CEBPB_22108803_ChIP-Seq_LS180_Human	1.14678969
78	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14272976
79	NFYA_21822215_ChIP-Seq_K562_Human	1.14123566
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13886809
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12486806
82	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.10497540
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.08852806
84	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.08048017
85	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05537515
86	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.05187676
87	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.04415869
88	KDM2B_26808549_Chip-Seq_REH_Human	1.04079377
89	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.03220825
90	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02350864
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02350864
92	CTCF_27219007_Chip-Seq_Bcells_Human	1.02335008
93	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01906519
94	CJUN_26792858_Chip-Seq_BT549_Human	1.00982067
95	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.00939008
96	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.00884103
97	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.00177889
98	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99110758
99	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.99013163
100	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.98762788

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	4.45694487
2	MP0003878_abnormal_ear_physiology	4.36445495
3	MP0005377_hearing/vestibular/ear_phenot	4.36445495
4	MP0001929_abnormal_gametogenesis	4.18987992
5	MP0005670_abnormal_white_adipose	3.96032555
6	MP0008877_abnormal_DNA_methylation	2.88842279
7	MP0003646_muscle_fatigue	2.79553592
8	MP0003718_maternal_effect	2.60072009
9	MP0002161_abnormal_fertility/fecundity	2.48855212
10	MP0002210_abnormal_sex_determination	2.35174276
11	MP0001348_abnormal_lacrimal_gland	2.03512310
12	MP0005410_abnormal_fertilization	10.8098609
13	MP0001145_abnormal_male_reproductive	1.87341760
14	MP0001485_abnormal_pinna_reflex	1.82956922
15	MP0000653_abnormal_sex_gland	1.82130819
16	MP0001486_abnormal_startle_reflex	1.76866892
17	MP0002282_abnormal_trachea_morphology	1.67960992
18	MP0002132_abnormal_respiratory_system	1.65139809
19	MP0005551_abnormal_eye_electrophysiolog	1.57999547
20	MP0005253_abnormal_eye_physiology	1.52735957
21	MP0003011_delayed_dark_adaptation	1.50976954
22	MP0005379_endocrine/exocrine_gland_phen	1.49722723
23	MP0005423_abnormal_somatic_nervous	1.40896529
24	MP0005310_abnormal_salivary_gland	1.40562853
25	MP0008789_abnormal_olfactory_epithelium	1.36896577
26	MP0008995_early_reproductive_senescence	1.31347585
27	MP0005395_other_phenotype	1.30227876
28	MP0000534_abnormal_ureter_morphology	1.24773536
29	MP0002735_abnormal_chemical_nociception	1.23938850
30	MP0002234_abnormal_pharynx_morphology	1.23061163
31	MP0001963_abnormal_hearing_physiology	1.18619771
32	MP0002127_abnormal_cardiovascular_syste	1.17026984
33	MP0009053_abnormal_anal_canal	1.15641809
34	MP0005248_abnormal_Harderian_gland	1.14077243
35	MP0004742_abnormal_vestibular_system	1.13705784
36	MP0000516_abnormal_urinary_system	1.09916125
37	MP0005367_renal/urinary_system_phenotyp	1.09916125
38	MP0005451_abnormal_body_composition	1.09873857
39	MP0000678_abnormal_parathyroid_gland	1.07573301
40	MP0002928_abnormal_bile_duct	1.05708045
41	MP0001968_abnormal_touch/_nociception	1.03667057
42	MP0002138_abnormal_hepatobiliary_system	1.03107099
43	MP0006292_abnormal_olfactory_placode	1.00921239
44	MP0001984_abnormal_olfaction	0.98280110
45	MP0000026_abnormal_inner_ear	0.98032786
46	MP0003077_abnormal_cell_cycle	0.94573787
47	MP0003787_abnormal_imprinting	0.92737116
48	MP0008058_abnormal_DNA_repair	0.92473956
49	MP0002229_neurodegeneration	0.91815360
50	MP0000955_abnormal_spinal_cord	0.89344300
51	MP0005394_taste/olfaction_phenotype	0.88749515
52	MP0005499_abnormal_olfactory_system	0.88749515
53	MP0002249_abnormal_larynx_morphology	0.88603094
54	MP0009697_abnormal_copulation	0.86695728
55	MP0009115_abnormal_fat_cell	0.86404181
56	MP0000049_abnormal_middle_ear	0.86196581
57	MP0001270_distended_abdomen	0.83549445
58	MP0002822_catalepsy	0.82648477
59	MP0005083_abnormal_biliary_tract	0.81016913
60	MP0005084_abnormal_gallbladder_morpholo	0.79044715
61	MP0002557_abnormal_social/conspecific_i	0.77541651
62	MP0005391_vision/eye_phenotype	0.75968855
63	MP0010329_abnormal_lipoprotein_level	0.74084027
64	MP0001765_abnormal_ion_homeostasis	0.73846027
65	MP0001666_abnormal_nutrient_absorption	0.69265203
66	MP0002067_abnormal_sensory_capabilities	0.68239219
67	MP0010386_abnormal_urinary_bladder	0.67775619
68	MP0003880_abnormal_central_pattern	0.67459032
69	MP0003136_yellow_coat_color	0.64855194
70	MP0003879_abnormal_hair_cell	0.64016331
71	MP0004085_abnormal_heartbeat	0.62661714
72	MP0000613_abnormal_salivary_gland	0.58177869
73	MP0001119_abnormal_female_reproductive	0.57217141
74	MP0006276_abnormal_autonomic_nervous	0.55693584
75	MP0003699_abnormal_female_reproductive	0.55647539
76	MP0003119_abnormal_digestive_system	0.54937649
77	MP0010094_abnormal_chromosome_stability	0.53174483
78	MP0004957_abnormal_blastocyst_morpholog	0.52474686
79	MP0008569_lethality_at_weaning	0.52101868
80	MP0003950_abnormal_plasma_membrane	0.51588082
81	MP0003861_abnormal_nervous_system	0.50954839
82	MP0004859_abnormal_synaptic_plasticity	0.48759927
83	MP0003385_abnormal_body_wall	0.48733054
84	MP0002168_other_aberrant_phenotype	0.48664070
85	MP0005666_abnormal_adipose_tissue	0.46066601
86	MP0002572_abnormal_emotion/affect_behav	0.46063483
87	MP0004036_abnormal_muscle_relaxation	0.45055014
88	MP0004043_abnormal_pH_regulation	0.44276492
89	MP0005195_abnormal_posterior_eye	0.43839749
90	MP0009745_abnormal_behavioral_response	0.43705133
91	MP0002752_abnormal_somatic_nervous	0.43460409
92	MP0002272_abnormal_nervous_system	0.43393029
93	MP0004484_altered_response_of	0.42308128
94	MP0005623_abnormal_meninges_morphology	0.42114622
95	MP0005636_abnormal_mineral_homeostasis	0.41587217
96	MP0002734_abnormal_mechanical_nocicepti	0.41412747
97	MP0003935_abnormal_craniofacial_develop	0.41340184
98	MP0001299_abnormal_eye_distance/	0.39910084
99	MP0000778_abnormal_nervous_system	0.38967398
100	MP0003755_abnormal_palate_morphology	0.38902818

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	7.47581903
2	Chronic hepatic failure (HP:0100626)	7.13483358
3	Absent/shortened dynein arms (HP:0200106)	6.06573698
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.06573698
5	Severe visual impairment (HP:0001141)	5.74171272
6	Abnormal ciliary motility (HP:0012262)	4.64969454
7	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.47093945
8	Abnormal respiratory motile cilium physiology (HP:0012261)	4.44517400
9	Hypoalphalipoproteinemia (HP:0003233)	4.28475398
10	Male infertility (HP:0003251)	4.24867427
11	Bony spicule pigmentary retinopathy (HP:0007737)	4.23376745
12	Abnormal respiratory epithelium morphology (HP:0012253)	4.22705367
13	Abnormal respiratory motile cilium morphology (HP:0005938)	4.22705367
14	Cone-rod dystrophy (HP:0000548)	4.13550578
15	Attenuation of retinal blood vessels (HP:0007843)	4.01900423
16	Hyperkalemia (HP:0002153)	3.79418175
17	Asymmetric septal hypertrophy (HP:0001670)	3.68980444
18	Nephronophthisis (HP:0000090)	3.52874403
19	Abnormality of macular pigmentation (HP:0008002)	3.51403957
20	Infertility (HP:0000789)	3.48277861
21	Tubulointerstitial abnormality (HP:0001969)	3.47838990
22	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.38270616
23	Truncal obesity (HP:0001956)	3.36993403
24	Hypoplasia of the thymus (HP:0000778)	3.28252157
25	Nasal polyposis (HP:0100582)	3.24825955
26	Resting tremor (HP:0002322)	3.21247296
27	Bell-shaped thorax (HP:0001591)	3.19621559
28	Menstrual irregularities (HP:0000858)	3.17283675
29	Abnormality of the renal medulla (HP:0100957)	3.13718660
30	Abnormal rod and cone electroretinograms (HP:0008323)	3.12509754
31	Stage 5 chronic kidney disease (HP:0003774)	3.07317948
32	Abnormal spermatogenesis (HP:0008669)	3.03624512
33	Azoospermia (HP:0000027)	2.99285255
34	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.97836124
35	Progressive sensorineural hearing impairment (HP:0000408)	2.97674624
36	Impulsivity (HP:0100710)	2.92088135
37	Rhinitis (HP:0012384)	2.84323660
38	Potter facies (HP:0002009)	2.73639583
39	Facial shape deformation (HP:0011334)	2.73639583
40	Portal hypertension (HP:0001409)	2.66493428
41	Volvulus (HP:0002580)	2.63214766
42	Progressive cerebellar ataxia (HP:0002073)	2.61161062
43	Intellectual disability, moderate (HP:0002342)	2.58211744
44	Renovascular hypertension (HP:0100817)	2.50841592
45	True hermaphroditism (HP:0010459)	2.49748112
46	Insulin-resistant diabetes mellitus (HP:0000831)	2.49020003
47	Abnormality of the hepatic vasculature (HP:0006707)	2.46037524
48	Postural instability (HP:0002172)	2.44812817
49	Hypolipoproteinemia (HP:0010981)	2.44592838
50	Abnormality of the nasal mucosa (HP:0000433)	2.44491329
51	Hypoplastic ischia (HP:0003175)	2.43665541
52	Abnormality of the ischium (HP:0003174)	2.43644362
53	Amelogenesis imperfecta (HP:0000705)	2.38139629
54	Hyperuricemia (HP:0002149)	2.37726240
55	Increased purine levels (HP:0004368)	2.37726240
56	Occipital encephalocele (HP:0002085)	2.34848868
57	Abnormality of dental color (HP:0011073)	2.30055038
58	Enlarged epiphyses (HP:0010580)	2.26380059
59	Pancreatic fibrosis (HP:0100732)	2.20346523
60	Chronic bronchitis (HP:0004469)	2.16897794
61	Tubular atrophy (HP:0000092)	2.16787787
62	Abnormal urine output (HP:0012590)	2.16611094
63	Osteomalacia (HP:0002749)	2.14767319
64	Abnormal drinking behavior (HP:0030082)	2.09353788
65	Polydipsia (HP:0001959)	2.09353788
66	Bronchiectasis (HP:0002110)	2.08593487
67	Abnormality of potassium homeostasis (HP:0011042)	2.00591260
68	Optic nerve hypoplasia (HP:0000609)	1.96908215
69	Pancreatic cysts (HP:0001737)	1.91957884
70	Subcapsular cataract (HP:0000523)	1.90576368
71	Abnormality of renal excretion (HP:0011036)	1.89385543
72	Obsessive-compulsive behavior (HP:0000722)	1.89361266
73	Decreased central vision (HP:0007663)	1.87086917
74	Renal dysplasia (HP:0000110)	1.84606063
75	Progressive hearing impairment (HP:0001730)	1.83534450
76	Polyuria (HP:0000103)	1.82441762
77	Focal segmental glomerulosclerosis (HP:0000097)	1.77103990
78	Hypophosphatemic rickets (HP:0004912)	1.76914440
79	Sandal gap (HP:0001852)	1.76516151
80	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.74805953
81	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.72741780
82	Horizontal nystagmus (HP:0000666)	1.71007955
83	Generalized aminoaciduria (HP:0002909)	1.70603654
84	Abnormality of the renal cortex (HP:0011035)	1.70484054
85	Median cleft lip (HP:0000161)	1.69001035
86	Molar tooth sign on MRI (HP:0002419)	1.68495837
87	Abnormality of midbrain morphology (HP:0002418)	1.68495837
88	Abnormality of the costochondral junction (HP:0000919)	1.68086453
89	Photophobia (HP:0000613)	1.67200406
90	Sex reversal (HP:0012245)	1.67150686
91	Abnormal sex determination (HP:0012244)	1.67150686
92	Gonadal dysgenesis (HP:0000133)	1.66030563
93	Abnormal ventriculo-arterial connection (HP:0011563)	1.65088691
94	Transposition of the great arteries (HP:0001669)	1.65088691
95	Abnormal connection of the cardiac segments (HP:0011545)	1.65088691
96	Small intestinal stenosis (HP:0012848)	1.64332159
97	Duodenal stenosis (HP:0100867)	1.64332159
98	Congenital sensorineural hearing impairment (HP:0008527)	1.64289463
99	Renal Fanconi syndrome (HP:0001994)	1.63268728
100	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.63199791

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.45734935
2	BRD4	4.44099826
3	PNCK	3.92351767
4	INSRR	3.36469006
5	PLK2	3.35579492
6	TESK1	3.00582502
7	STK38	2.67008527
8	STK38L	2.54279563
9	MAP4K2	2.53956421
10	DDR2	2.44521354
11	CAMK1G	2.42980066
12	MAPK15	2.24511125
13	PRKD3	2.06947628
14	BMPR1B	1.89852713
15	AKT3	1.74291362
16	WNK3	1.71345623
17	PIK3CG	1.68699062
18	LMTK2	1.67514230
19	NEK6	1.57256633
20	STK39	1.52854261
21	ACVR1B	1.44012761
22	BRSK2	1.43973226
23	FRK	1.22525575
24	DYRK1B	1.16457924
25	PINK1	0.99881741
26	TNIK	0.99221400
27	PTK2B	0.98911389
28	PDK1	0.96021257
29	WNK1	0.94158308
30	MARK1	0.92755490
31	TYRO3	0.90181866
32	MKNK2	0.87632407
33	PDPK1	0.84210045
34	MUSK	0.83610862
35	CAMK1D	0.81533644
36	WNK4	0.81436930
37	MST1R	0.81270821
38	OXSR1	0.80875292
39	MAP3K4	0.78178824
40	CDK12	0.73717565
41	BRSK1	0.73013540
42	CDK7	0.70457810
43	NTRK2	0.67827541
44	CASK	0.66082964
45	CDK3	0.64590647
46	PDK2	0.63927409
47	TIE1	0.63784096
48	PBK	0.61967091
49	PRKG1	0.60034589
50	ROCK1	0.59971394
51	DYRK3	0.58991185
52	SGK223	0.58703322
53	SGK494	0.58703322
54	PKN1	0.56901068
55	CCNB1	0.55530580
56	MAPK13	0.55306225
57	PLK1	0.52062960
58	KSR2	0.51867830
59	PRKG2	0.51860931
60	NTRK3	0.50948234
61	NUAK1	0.50152091
62	SGK2	0.46666930
63	MARK3	0.46270472
64	CHEK1	0.44429337
65	CDK1	0.44286639
66	BRAF	0.43810427
67	TGFBR1	0.43791273
68	CDK2	0.43568526
69	SIK2	0.42302287
70	CAMK1	0.42130025
71	SGK1	0.40729543
72	WEE1	0.40497114
73	GSK3B	0.38818550
74	EIF2AK3	0.38382811
75	MAP3K2	0.37699820
76	PRKAA2	0.35723106
77	NEK2	0.34809956
78	RIPK1	0.34544520
79	PLK3	0.34528706
80	RPS6KA1	0.34514426
81	MAPK1	0.34111601
82	LATS1	0.32995758
83	MINK1	0.30485707
84	PRKCE	0.30415976
85	MAP2K7	0.30344444
86	TSSK6	0.29493005
87	ATM	0.29473169
88	TTK	0.28965844
89	MKNK1	0.28420054
90	MAP3K8	0.27367432
91	DYRK1A	0.26415184
92	PRKCG	0.26131385
93	ZAK	0.25235243
94	MAPK8	0.24841134
95	MAPK14	0.24135807
96	RPS6KA2	0.23452738
97	VRK1	0.21687936
98	UHMK1	0.20993618
99	PRKCB	0.20795850
100	CAMK4	0.18824828

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.00058360
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	6.30017375
3	Olfactory transduction_Homo sapiens_hsa04740	3.24201493
4	Butanoate metabolism_Homo sapiens_hsa00650	3.09439077
5	Fatty acid degradation_Homo sapiens_hsa00071	2.31425460
6	RNA transport_Homo sapiens_hsa03013	2.21944503
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.21593795
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.15980981
9	Fatty acid metabolism_Homo sapiens_hsa01212	1.87972649
10	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.81530028
11	ABC transporters_Homo sapiens_hsa02010	1.67406830
12	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.65215632
13	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.65144246
14	Phototransduction_Homo sapiens_hsa04744	1.49231705
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.48072488
16	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.45161809
17	Taste transduction_Homo sapiens_hsa04742	1.44071629
18	Propanoate metabolism_Homo sapiens_hsa00640	1.33261877
19	Circadian rhythm_Homo sapiens_hsa04710	1.31574527
20	Oocyte meiosis_Homo sapiens_hsa04114	1.25659252
21	Basal transcription factors_Homo sapiens_hsa03022	1.24668975
22	Non-homologous end-joining_Homo sapiens_hsa03450	1.15351191
23	Lysine degradation_Homo sapiens_hsa00310	1.13045307
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.10155269
25	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.06854768
26	Retinol metabolism_Homo sapiens_hsa00830	1.05560552
27	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.05253651
28	Arginine and proline metabolism_Homo sapiens_hsa00330	1.03157408
29	PPAR signaling pathway_Homo sapiens_hsa03320	1.02869038
30	Glycerolipid metabolism_Homo sapiens_hsa00561	1.01668118
31	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.01312073
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.00660497
33	Phenylalanine metabolism_Homo sapiens_hsa00360	0.91656486
34	Fat digestion and absorption_Homo sapiens_hsa04975	0.87026063
35	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.87011272
36	Type II diabetes mellitus_Homo sapiens_hsa04930	0.82482667
37	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82370417
38	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.82139660
39	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.79031597
40	Homologous recombination_Homo sapiens_hsa03440	0.77344468
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75722569
42	Selenocompound metabolism_Homo sapiens_hsa00450	0.75675655
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.75387973
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.74146636
45	Calcium signaling pathway_Homo sapiens_hsa04020	0.72926273
46	Salivary secretion_Homo sapiens_hsa04970	0.70778395
47	One carbon pool by folate_Homo sapiens_hsa00670	0.70390561
48	Peroxisome_Homo sapiens_hsa04146	0.68841979
49	Protein digestion and absorption_Homo sapiens_hsa04974	0.68718744
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67179941
51	Nicotine addiction_Homo sapiens_hsa05033	0.66650407
52	cAMP signaling pathway_Homo sapiens_hsa04024	0.66093815
53	Morphine addiction_Homo sapiens_hsa05032	0.61829978
54	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.60064731
55	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.59956529
56	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56718851
57	mRNA surveillance pathway_Homo sapiens_hsa03015	0.55259827
58	Arginine biosynthesis_Homo sapiens_hsa00220	0.53963100
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53885319
60	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.53716847
61	Pancreatic secretion_Homo sapiens_hsa04972	0.53475193
62	Tight junction_Homo sapiens_hsa04530	0.53201102
63	Circadian entrainment_Homo sapiens_hsa04713	0.53181336
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52622098
65	Endocytosis_Homo sapiens_hsa04144	0.51762890
66	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.48855555
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48526382
68	Cell cycle_Homo sapiens_hsa04110	0.47463663
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47258961
70	Tyrosine metabolism_Homo sapiens_hsa00350	0.47170035
71	Glutamatergic synapse_Homo sapiens_hsa04724	0.46715425
72	Linoleic acid metabolism_Homo sapiens_hsa00591	0.46433588
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.45963590
74	Nitrogen metabolism_Homo sapiens_hsa00910	0.45730880
75	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.45243831
76	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.45091291
77	Base excision repair_Homo sapiens_hsa03410	0.44662690
78	Purine metabolism_Homo sapiens_hsa00230	0.41660736
79	Adherens junction_Homo sapiens_hsa04520	0.40077110
80	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39050015
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38865851
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.37559254
83	Estrogen signaling pathway_Homo sapiens_hsa04915	0.37098797
84	Huntingtons disease_Homo sapiens_hsa05016	0.36595699
85	Bile secretion_Homo sapiens_hsa04976	0.36282159
86	Serotonergic synapse_Homo sapiens_hsa04726	0.35463790
87	Tryptophan metabolism_Homo sapiens_hsa00380	0.34577440
88	Regulation of autophagy_Homo sapiens_hsa04140	0.34163286
89	Carbon metabolism_Homo sapiens_hsa01200	0.33396108
90	Metabolic pathways_Homo sapiens_hsa01100	0.33339309
91	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.32274543
92	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.28885041
93	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.28755055
94	Gastric acid secretion_Homo sapiens_hsa04971	0.28338010
95	Antigen processing and presentation_Homo sapiens_hsa04612	0.26621964
96	Influenza A_Homo sapiens_hsa05164	0.26332864
97	Renin secretion_Homo sapiens_hsa04924	0.25962121
98	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.24765305
99	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.23863406
100	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.22975562

C6ORF201

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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