ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	4.81439889
2	urea cycle (GO:0000050)	4.63455878
3	regulation of apoptotic process involved in morphogenesis (GO:1902337)	4.61940088
4	T-helper 1 type immune response (GO:0042088)	4.57895674
5	low-density lipoprotein particle clearance (GO:0034383)	4.31681060
6	GDP-mannose metabolic process (GO:0019673)	4.21920495
7	diaphragm development (GO:0060539)	4.11285577
8	activation of Rac GTPase activity (GO:0032863)	4.04678172
9	urea metabolic process (GO:0019627)	4.03306569
10	protein localization to chromosome, centromeric region (GO:0071459)	3.90664198
11	regulation of spindle checkpoint (GO:0090231)	3.88352174
12	T cell lineage commitment (GO:0002360)	3.85573536
13	positive regulation of cell cycle checkpoint (GO:1901978)	3.82117646
14	citrulline metabolic process (GO:0000052)	3.81710588
15	regulation of cholesterol homeostasis (GO:2000188)	3.78082416
16	atrioventricular valve morphogenesis (GO:0003181)	3.77741879
17	mitotic chromosome condensation (GO:0007076)	3.72477315
18	innate immune response in mucosa (GO:0002227)	3.70135267
19	cellular response to arsenic-containing substance (GO:0071243)	3.59249124
20	nitrogen cycle metabolic process (GO:0071941)	3.55720178
21	regulation of vitamin D biosynthetic process (GO:0060556)	3.54488494
22	activation of MAPKKK activity (GO:0000185)	3.53541380
23	skeletal muscle organ development (GO:0060538)	3.47775756
24	folic acid metabolic process (GO:0046655)	3.46939286
25	NIK/NF-kappaB signaling (GO:0038061)	3.45106522
26	regulation of translational fidelity (GO:0006450)	3.44082684
27	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	3.37832052
28	germinal center formation (GO:0002467)	3.35125325
29	snRNA metabolic process (GO:0016073)	3.30850335
30	proline biosynthetic process (GO:0006561)	3.30010199
31	DNA unwinding involved in DNA replication (GO:0006268)	3.26431894
32	endothelial cell chemotaxis (GO:0035767)	3.21020223
33	response to laminar fluid shear stress (GO:0034616)	3.20821224
34	DNA strand elongation involved in DNA replication (GO:0006271)	3.20255992
35	midgut development (GO:0007494)	3.19244858
36	mitotic sister chromatid cohesion (GO:0007064)	3.18252798
37	positive regulation of protein kinase C signaling (GO:0090037)	3.11978691
38	nuclear envelope reassembly (GO:0031468)	3.10706352
39	mitotic nuclear envelope reassembly (GO:0007084)	3.10706352
40	mRNA cleavage (GO:0006379)	3.09140570
41	antimicrobial humoral response (GO:0019730)	3.07562959
42	DNA strand elongation (GO:0022616)	3.06179692
43	positive regulation of p38MAPK cascade (GO:1900745)	3.03370167
44	proline metabolic process (GO:0006560)	3.01501777
45	telomere maintenance via semi-conservative replication (GO:0032201)	3.00182088
46	organ or tissue specific immune response (GO:0002251)	2.97158921
47	homocysteine metabolic process (GO:0050667)	2.96523677
48	mucosal immune response (GO:0002385)	2.96422485
49	ribosomal small subunit biogenesis (GO:0042274)	2.95454376
50	positive regulation of lipid storage (GO:0010884)	2.93813124
51	mitochondrial DNA metabolic process (GO:0032042)	2.91756857
52	negative regulation of gluconeogenesis (GO:0045721)	2.90125474
53	mitotic sister chromatid segregation (GO:0000070)	2.88303735
54	tRNA methylation (GO:0030488)	2.86779138
55	regulation of vitamin metabolic process (GO:0030656)	2.85991834
56	regulation of chromatin binding (GO:0035561)	2.85449403
57	embryonic process involved in female pregnancy (GO:0060136)	2.84743545
58	regulation of triglyceride biosynthetic process (GO:0010866)	2.84710719
59	antibacterial humoral response (GO:0019731)	2.84319243
60	regulation of interferon-gamma biosynthetic process (GO:0045072)	2.79211284
61	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.74814635
62	positive regulation of vascular permeability (GO:0043117)	2.73057697
63	modulation by symbiont of host cellular process (GO:0044068)	2.71839666
64	glutamine family amino acid biosynthetic process (GO:0009084)	2.71353617
65	COPI coating of Golgi vesicle (GO:0048205)	2.70956677
66	Golgi transport vesicle coating (GO:0048200)	2.70956677
67	activation of NF-kappaB-inducing kinase activity (GO:0007250)	2.70541247
68	surfactant homeostasis (GO:0043129)	2.69502465
69	regulation of anoikis (GO:2000209)	2.69069317
70	glucose 6-phosphate metabolic process (GO:0051156)	2.68179224
71	snRNA processing (GO:0016180)	2.66514534
72	regulation of cell cycle checkpoint (GO:1901976)	2.66029088
73	negative regulation of viral release from host cell (GO:1902187)	2.63942365
74	tricarboxylic acid metabolic process (GO:0072350)	2.62179432
75	glycolytic process (GO:0006096)	2.59855314
76	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.58859547
77	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.57394310
78	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	2.57331495
79	DNA replication-dependent nucleosome organization (GO:0034723)	2.56617722
80	DNA replication-dependent nucleosome assembly (GO:0006335)	2.56617722
81	meiotic chromosome segregation (GO:0045132)	2.55144227
82	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	2.54991410
83	regulation of cell migration involved in sprouting angiogenesis (GO:0090049)	2.52812037
84	lung vasculature development (GO:0060426)	2.51925754
85	apoptotic process involved in morphogenesis (GO:0060561)	2.50511283
86	immunoglobulin mediated immune response (GO:0016064)	2.48797870
87	ncRNA 3-end processing (GO:0043628)	2.46381063
88	folic acid-containing compound biosynthetic process (GO:0009396)	2.45811133
89	entrainment of circadian clock by photoperiod (GO:0043153)	2.45732062
90	regulation of histone H3-K27 methylation (GO:0061085)	2.45435071
91	mature B cell differentiation involved in immune response (GO:0002313)	2.44344786
92	rRNA methylation (GO:0031167)	2.44316937
93	regulation of cholesterol storage (GO:0010885)	2.43117293
94	response to arsenic-containing substance (GO:0046685)	2.41346926
95	response to peptidoglycan (GO:0032494)	2.41005179
96	mitotic nuclear envelope disassembly (GO:0007077)	2.40761772
97	histone phosphorylation (GO:0016572)	2.37909264
98	telomere maintenance via recombination (GO:0000722)	2.37653451
99	DNA replication initiation (GO:0006270)	2.36873180
100	positive regulation of odontogenesis (GO:0042482)	2.35307398

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.22523204
2	E2F7_22180533_ChIP-Seq_HELA_Human	3.75773070
3	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.17073101
4	MYC_22102868_ChIP-Seq_BL_Human	3.08228824
5	ZNF263_19887448_ChIP-Seq_K562_Human	3.00593331
6	* VDR_21846776_ChIP-Seq_THP-1_Human	2.76505240
7	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.69310094
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.39056202
9	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.24378359
10	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.16128837
11	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.03071794
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.02418621
13	LXR_22292898_ChIP-Seq_THP-1_Human	1.98080347
14	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.94632528
15	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.89238127
16	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.88498083
17	XRN2_22483619_ChIP-Seq_HELA_Human	1.87766208
18	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.81072474
19	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.80849943
20	RACK7_27058665_Chip-Seq_MCF-7_Human	1.76496042
21	MAF_26560356_Chip-Seq_TH1_Human	1.75298363
22	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.72588619
23	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.70553807
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.65019129
25	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.62518618
26	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.58490972
27	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.57330183
28	ATF3_27146783_Chip-Seq_COLON_Human	1.56205162
29	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.55788584
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.53418152
31	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.53139034
32	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.48369363
33	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.47980160
34	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.46980468
35	P68_20966046_ChIP-Seq_HELA_Human	1.41209310
36	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.40471914
37	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.39188296
38	UTX_26944678_Chip-Seq_JUKART_Human	1.38965445
39	MAF_26560356_Chip-Seq_TH2_Human	1.37635522
40	TCF7_22412390_ChIP-Seq_EML_Mouse	1.37318451
41	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.35962373
42	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.35101512
43	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.33285676
44	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.33056513
45	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.30875429
46	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.30578975
47	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.30484616
48	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.30134956
49	* VDR_24763502_ChIP-Seq_THP-1_Human	1.27659434
50	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.26712283
51	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.25983767
52	KDM2B_26808549_Chip-Seq_DND41_Human	1.25546955
53	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.25386051
54	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.25237506
55	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.25132237
56	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.24098175
57	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.23517916
58	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.22598695
59	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.22154291
60	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.22067582
61	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.19244502
62	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.18076678
63	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.17901618
64	BCOR_27268052_Chip-Seq_Bcells_Human	1.17865846
65	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.17418769
66	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.14455604
67	CIITA_25753668_ChIP-Seq_RAJI_Human	1.14405314
68	NCOR1_26117541_ChIP-Seq_K562_Human	1.13745885
69	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13424506
70	CREB1_26743006_Chip-Seq_LNCaP_Human	1.12366864
71	SMC4_20622854_ChIP-Seq_HELA_Human	1.12081856
72	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.11878797
73	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.11609023
74	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.09657669
75	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.08578570
76	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.08291186
77	TP53_22127205_ChIP-Seq_IMR90_Human	1.07993346
78	* UBF1/2_26484160_Chip-Seq_HMECs_Human	1.07910853
79	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.07178026
80	TTF2_22483619_ChIP-Seq_HELA_Human	1.07058434
81	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.06414152
82	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.06031078
83	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.05105880
84	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.04734822
85	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.04473840
86	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.04015046
87	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.03171817
88	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.01522480
89	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.01406212
90	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.00390952
91	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.00320195
92	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.99581142
93	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.99304678
94	GABP_19822575_ChIP-Seq_HepG2_Human	0.99029825
95	CLOCK_20551151_ChIP-Seq_293T_Human	0.98115862
96	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.96554247
97	BRD4_27068464_Chip-Seq_AML-cells_Mouse	0.96387229
98	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.96252096
99	* CTCF_21964334_Chip-Seq_Bcells_Human	0.94966645
100	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.94710510

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005076_abnormal_cell_differentiation	3.26718628
2	MP0005083_abnormal_biliary_tract	3.17813690
3	MP0010234_abnormal_vibrissa_follicle	3.15389325
4	MP0005623_abnormal_meninges_morphology	3.11520514
5	MP0005451_abnormal_body_composition	2.87010294
6	MP0004808_abnormal_hematopoietic_stem	2.78378917
7	MP0002877_abnormal_melanocyte_morpholog	2.69200972
8	MP0010094_abnormal_chromosome_stability	2.65425757
9	MP0003111_abnormal_nucleus_morphology	2.62682895
10	MP0003693_abnormal_embryo_hatching	2.54594240
11	MP0000490_abnormal_crypts_of	2.50233416
12	MP0000685_abnormal_immune_system	2.43464383
13	MP0002139_abnormal_hepatobiliary_system	2.39539754
14	MP0009840_abnormal_foam_cell	2.25689092
15	MP0010030_abnormal_orbit_morphology	2.18104480
16	MP0003077_abnormal_cell_cycle	2.16816469
17	MP0003763_abnormal_thymus_physiology	2.01139081
18	MP0003303_peritoneal_inflammation	1.99282777
19	MP0004233_abnormal_muscle_weight	1.98275941
20	MP0004957_abnormal_blastocyst_morpholog	1.97152669
21	MP0003705_abnormal_hypodermis_morpholog	1.84011402
22	MP0003453_abnormal_keratinocyte_physiol	1.83756465
23	MP0002396_abnormal_hematopoietic_system	1.81783854
24	MP0008057_abnormal_DNA_replication	1.81453265
25	MP0001790_abnormal_immune_system	1.62464936
26	MP0005387_immune_system_phenotype	1.62464936
27	MP0004947_skin_inflammation	1.61245836
28	MP0001661_extended_life_span	1.60258704
29	MP0004185_abnormal_adipocyte_glucose	1.59979941
30	MP0001800_abnormal_humoral_immune	1.58847602
31	MP0005501_abnormal_skin_physiology	1.51260559
32	MP0010352_gastrointestinal_tract_polyps	1.48829709
33	MP0005000_abnormal_immune_tolerance	1.45563565
34	MP0001849_ear_inflammation	1.39343683
35	MP0008058_abnormal_DNA_repair	1.39123352
36	MP0000350_abnormal_cell_proliferation	1.38641697
37	MP0000003_abnormal_adipose_tissue	1.37021041
38	MP0009333_abnormal_splenocyte_physiolog	1.35022416
39	MP0002398_abnormal_bone_marrow	1.34779890
40	MP0003123_paternal_imprinting	1.34673845
41	MP0003436_decreased_susceptibility_to	1.33329798
42	MP0001348_abnormal_lacrimal_gland	1.31488641
43	MP0002452_abnormal_antigen_presenting	1.31310645
44	MP0008007_abnormal_cellular_replicative	1.26419208
45	MP0004264_abnormal_extraembryonic_tissu	1.26103573
46	MP0002796_impaired_skin_barrier	1.24838582
47	MP0002723_abnormal_immune_serum	1.24397656
48	MP0002019_abnormal_tumor_incidence	1.21057468
49	MP0010307_abnormal_tumor_latency	1.20423645
50	MP0005666_abnormal_adipose_tissue	1.18960504
51	MP0002722_abnormal_immune_system	1.18515491
52	MP0002166_altered_tumor_susceptibility	1.14876696
53	MP0010155_abnormal_intestine_physiology	1.14572333
54	MP0001835_abnormal_antigen_presentation	1.11229822
55	MP0003091_abnormal_cell_migration	1.11111949
56	MP0002006_tumorigenesis	1.09828168
57	MP0002429_abnormal_blood_cell	1.09558400
58	MP0008932_abnormal_embryonic_tissue	1.09498392
59	MP0000313_abnormal_cell_death	1.08735574
60	MP0005621_abnormal_cell_physiology	1.08478204
61	MP0003959_abnormal_lean_body	1.08216079
62	MP0005375_adipose_tissue_phenotype	1.07863855
63	MP0000716_abnormal_immune_system	1.04684893
64	MP0002970_abnormal_white_adipose	1.03762882
65	MP0000858_altered_metastatic_potential	1.03742841
66	MP0000689_abnormal_spleen_morphology	1.02729976
67	MP0002089_abnormal_postnatal_growth/wei	1.02029035
68	MP0002420_abnormal_adaptive_immunity	1.01233205
69	MP0009278_abnormal_bone_marrow	1.00761821
70	MP0001819_abnormal_immune_cell	1.00514893
71	MP0001216_abnormal_epidermal_layer	0.99971903
72	MP0000703_abnormal_thymus_morphology	0.98983147
73	MP0005671_abnormal_response_to	0.94231004
74	MP0005332_abnormal_amino_acid	0.92866041
75	MP0002060_abnormal_skin_morphology	0.92649119
76	MP0009931_abnormal_skin_appearance	0.92429276
77	MP0000609_abnormal_liver_physiology	0.91590226
78	MP0003300_gastrointestinal_ulcer	0.91257315
79	MP0003984_embryonic_growth_retardation	0.91111021
80	MP0002086_abnormal_extraembryonic_tissu	0.91082349
81	MP0002080_prenatal_lethality	0.89401997
82	MP0002148_abnormal_hypersensitivity_rea	0.88469541
83	MP0002009_preneoplasia	0.87040783
84	MP0003566_abnormal_cell_adhesion	0.86289352
85	MP0005384_cellular_phenotype	0.85615510
86	MP0002088_abnormal_embryonic_growth/wei	0.85199420
87	MP0002405_respiratory_system_inflammati	0.84510552
88	MP0005058_abnormal_lysosome_morphology	0.84129706
89	MP0005220_abnormal_exocrine_pancreas	0.84016959
90	MP0002163_abnormal_gland_morphology	0.83125998
91	MP0002971_abnormal_brown_adipose	0.82908956
92	MP0001730_embryonic_growth_arrest	0.81147261
93	MP0002332_abnormal_exercise_endurance	0.80419125
94	MP0005670_abnormal_white_adipose	0.78923770
95	MP0005025_abnormal_response_to	0.78471336
96	MP0010678_abnormal_skin_adnexa	0.77259228
97	MP0000358_abnormal_cell_content/	0.76215013
98	MP0005584_abnormal_enzyme/coenzyme_acti	0.74376874
99	MP0001853_heart_inflammation	0.73714590
100	MP0000477_abnormal_intestine_morphology	0.73554279

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Squamous cell carcinoma (HP:0002860)	5.42922016
2	Hemorrhage of the eye (HP:0011885)	3.97856279
3	Renal duplication (HP:0000075)	3.93452130
4	Gastrointestinal stroma tumor (HP:0100723)	3.80024077
5	Abnormality of pyrimidine metabolism (HP:0004353)	3.40807965
6	Malnutrition (HP:0004395)	3.37366185
7	Hyperacusis (HP:0010780)	3.35527867
8	Microvesicular hepatic steatosis (HP:0001414)	3.25171650
9	IgA deficiency (HP:0002720)	3.19991968
10	Ragged-red muscle fibers (HP:0003200)	3.16992418
11	Progressive muscle weakness (HP:0003323)	3.15091288
12	Colitis (HP:0002583)	3.03870753
13	Long palpebral fissure (HP:0000637)	3.00212866
14	Poikiloderma (HP:0001029)	2.86626177
15	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.84158128
16	Abnormality of glycolysis (HP:0004366)	2.79151707
17	Progressive external ophthalmoplegia (HP:0000590)	2.78588215
18	Dyschromatopsia (HP:0007641)	2.74589569
19	Distal lower limb amyotrophy (HP:0008944)	2.72678276
20	Flat cornea (HP:0007720)	2.70283997
21	Abnormality of the nasal septum (HP:0000419)	2.61320306
22	Insomnia (HP:0100785)	2.53870973
23	Sparse lateral eyebrow (HP:0005338)	2.47396038
24	Abnormality of placental membranes (HP:0011409)	2.47050783
25	Amniotic constriction ring (HP:0009775)	2.47050783
26	Emphysema (HP:0002097)	2.45408346
27	Milia (HP:0001056)	2.40528202
28	Breast hypoplasia (HP:0003187)	2.32923378
29	Popliteal pterygium (HP:0009756)	2.25110903
30	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.24983692
31	Rough bone trabeculation (HP:0100670)	2.20172723
32	Basal cell carcinoma (HP:0002671)	2.19189908
33	Abnormality of the intrinsic pathway (HP:0010989)	2.17796802
34	Cellulitis (HP:0100658)	2.17178232
35	Villous atrophy (HP:0011473)	2.15132983
36	Abnormality of small intestinal villus morphology (HP:0011472)	2.15132983
37	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.15021958
38	Progressive hearing impairment (HP:0001730)	2.12594345
39	Abnormal trabecular bone morphology (HP:0100671)	2.12019284
40	Hypertensive crisis (HP:0100735)	2.09450390
41	Agammaglobulinemia (HP:0004432)	2.07831943
42	Fatigue (HP:0012378)	2.02326740
43	Overriding aorta (HP:0002623)	1.99708394
44	Increased serum pyruvate (HP:0003542)	1.99281878
45	Chromsome breakage (HP:0040012)	1.98986311
46	Premature graying of hair (HP:0002216)	1.98462239
47	Cheilitis (HP:0100825)	1.96545844
48	Proximal placement of thumb (HP:0009623)	1.94685250
49	Abnormal hair laboratory examination (HP:0003328)	1.94086400
50	Deviation of the thumb (HP:0009603)	1.92143232
51	Ankyloglossia (HP:0010296)	1.91189543
52	Unilateral renal agenesis (HP:0000122)	1.90085771
53	Elfin facies (HP:0004428)	1.89656671
54	Cholecystitis (HP:0001082)	1.89457782
55	Abnormal gallbladder physiology (HP:0012438)	1.89457782
56	Broad face (HP:0000283)	1.89018182
57	Alkalosis (HP:0001948)	1.88048750
58	Lymphoma (HP:0002665)	1.87291060
59	Premature ovarian failure (HP:0008209)	1.86931229
60	Aplasia cutis congenita (HP:0001057)	1.86374783
61	Gastrointestinal inflammation (HP:0004386)	1.86225123
62	Testicular atrophy (HP:0000029)	1.85493411
63	Prominent nose (HP:0000448)	1.84570841
64	Focal segmental glomerulosclerosis (HP:0000097)	1.83557477
65	Lymphopenia (HP:0001888)	1.83457992
66	Rib fusion (HP:0000902)	1.83326112
67	IgM deficiency (HP:0002850)	1.83249408
68	Fragile skin (HP:0001030)	1.83234720
69	Choroideremia (HP:0001139)	1.81737476
70	Recurrent viral infections (HP:0004429)	1.81270518
71	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.81173449
72	Lip pit (HP:0100267)	1.80342193
73	Inflammation of the large intestine (HP:0002037)	1.80278367
74	Trismus (HP:0000211)	1.80057578
75	Upper limb amyotrophy (HP:0009129)	1.79241166
76	Distal upper limb amyotrophy (HP:0007149)	1.79241166
77	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.78483541
78	Micronodular cirrhosis (HP:0001413)	1.77892382
79	Hepatitis (HP:0012115)	1.77735531
80	Ectopia lentis (HP:0001083)	1.76752856
81	Entropion (HP:0000621)	1.76325697
82	Progressive sensorineural hearing impairment (HP:0000408)	1.75564635
83	Elbow flexion contracture (HP:0002987)	1.75067185
84	Hyperammonemia (HP:0001987)	1.72439424
85	Recurrent sinusitis (HP:0011108)	1.70565089
86	Birth length less than 3rd percentile (HP:0003561)	1.68389007
87	Abnormality of the fingertips (HP:0001211)	1.68143919
88	Esophageal neoplasm (HP:0100751)	1.67924715
89	Neoplasm of head and neck (HP:0012288)	1.67924715
90	Reduced antithrombin III activity (HP:0001976)	1.64993626
91	Neonatal onset (HP:0003623)	1.64066634
92	Recurrent corneal erosions (HP:0000495)	1.62391103
93	Thin bony cortex (HP:0002753)	1.62037847
94	Impaired proprioception (HP:0010831)	1.61837078
95	Axonal loss (HP:0003447)	1.61740983
96	Abnormal ossification of hand bones (HP:0005921)	1.61720967
97	Viral hepatitis (HP:0006562)	1.59858549
98	Abnormality of the gastric mucosa (HP:0004295)	1.58997414
99	Leukopenia (HP:0001882)	1.58753064
100	Pili torti (HP:0003777)	1.58444436

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.70459760
2	ZAK	3.99964757
3	MST1R	3.93291547
4	ICK	3.93023788
5	EPHA2	3.60623928
6	PDK2	3.48362914
7	IRAK3	3.35238019
8	STK16	2.76747476
9	PIM2	2.69521822
10	SMG1	2.55176884
11	NME2	2.26092756
12	EEF2K	2.22036502
13	ERN1	2.21719696
14	SIK1	2.19733802
15	CDK12	2.08950722
16	PRPF4B	1.93360924
17	MAPK11	1.93267704
18	MAP4K1	1.73356376
19	TRIB3	1.61001859
20	VRK1	1.55267371
21	RPS6KA5	1.51287531
22	TESK2	1.50649215
23	TAOK2	1.47784500
24	NME1	1.47011290
25	LATS2	1.46300462
26	MAP3K14	1.40263423
27	MET	1.39035073
28	MAP3K13	1.09132229
29	BUB1	1.05071897
30	ARAF	1.02817656
31	FGFR4	1.01818371
32	MTOR	0.98732367
33	MAP3K10	0.96874519
34	IKBKB	0.96242107
35	SIK2	0.95981526
36	AURKA	0.88795555
37	MAP3K11	0.86824960
38	MAP3K9	0.86711656
39	PDPK1	0.84493723
40	PIM1	0.82073174
41	NEK9	0.82070868
42	MAP3K8	0.81983378
43	CDC7	0.81454920
44	CDK4	0.80711842
45	RPS6KB2	0.79982737
46	IRAK4	0.78165851
47	RAF1	0.75241102
48	LMTK2	0.73102169
49	MAP2K2	0.69736191
50	CHEK2	0.69641053
51	MAP3K1	0.69602726
52	STK24	0.68956053
53	VRK2	0.68119653
54	BRAF	0.66963945
55	BLK	0.66121613
56	AURKB	0.65600830
57	CDK6	0.64472390
58	TBK1	0.64009972
59	WEE1	0.60978205
60	SIK3	0.57894803
61	CDK8	0.56792452
62	SRPK1	0.56319886
63	CDK7	0.56279557
64	AKT2	0.55308416
65	TAOK1	0.53285350
66	MAPKAPK5	0.52495106
67	PDK1	0.50243757
68	NEK1	0.50004120
69	MELK	0.49765392
70	MAPKAPK3	0.45763314
71	MAPK12	0.45268058
72	WNK4	0.44503672
73	CHUK	0.44232192
74	MAP2K3	0.43591987
75	DAPK3	0.43226025
76	PDGFRA	0.42933006
77	CHEK1	0.41250339
78	CCNB1	0.40270124
79	CDK9	0.37277709
80	STK10	0.37224988
81	MAP3K3	0.36614554
82	ATR	0.36044337
83	PRKCI	0.32398123
84	NEK6	0.32197801
85	NEK2	0.31557095
86	RIPK4	0.31509872
87	PKN2	0.31476135
88	RPS6KL1	0.29672436
89	RPS6KC1	0.29672436
90	HIPK2	0.27840812
91	PRKAA1	0.26826354
92	RPS6KA1	0.26656345
93	BCKDK	0.24519656
94	EIF2AK3	0.24363088
95	IRAK2	0.24303275
96	MAPK7	0.23893079
97	TTK	0.22779667
98	PKN1	0.21015636
99	BRD4	0.20875928
100	PBK	0.20492451

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	6.04168803
2	Alcoholism_Homo sapiens_hsa05034	4.00549863
3	Sulfur relay system_Homo sapiens_hsa04122	3.35792042
4	DNA replication_Homo sapiens_hsa03030	2.84310633
5	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.77658131
6	Viral carcinogenesis_Homo sapiens_hsa05203	2.41807084
7	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.36119277
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.18946073
9	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.02682516
10	Arginine biosynthesis_Homo sapiens_hsa00220	1.88921118
11	Folate biosynthesis_Homo sapiens_hsa00790	1.81370768
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.78290381
13	Base excision repair_Homo sapiens_hsa03410	1.73367143
14	Bladder cancer_Homo sapiens_hsa05219	1.64191475
15	Pentose phosphate pathway_Homo sapiens_hsa00030	1.62371791
16	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.57557238
17	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.45557358
18	Mismatch repair_Homo sapiens_hsa03430	1.37272062
19	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.33878979
20	Primary immunodeficiency_Homo sapiens_hsa05340	1.32190154
21	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.31796268
22	Carbon metabolism_Homo sapiens_hsa01200	1.28922234
23	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.27335407
24	Cell cycle_Homo sapiens_hsa04110	1.26463484
25	Allograft rejection_Homo sapiens_hsa05330	1.26259381
26	Herpes simplex infection_Homo sapiens_hsa05168	1.21251486
27	Galactose metabolism_Homo sapiens_hsa00052	1.20914930
28	Small cell lung cancer_Homo sapiens_hsa05222	1.19942396
29	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.17246693
30	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.15348002
31	Graft-versus-host disease_Homo sapiens_hsa05332	1.15282815
32	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.13875578
33	Influenza A_Homo sapiens_hsa05164	1.07824103
34	One carbon pool by folate_Homo sapiens_hsa00670	1.06356569
35	Apoptosis_Homo sapiens_hsa04210	1.03852195
36	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.02220902
37	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.02092530
38	Ribosome_Homo sapiens_hsa03010	0.98830808
39	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.98727118
40	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.98563657
41	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.98153352
42	Homologous recombination_Homo sapiens_hsa03440	0.96466838
43	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.95312136
44	Nucleotide excision repair_Homo sapiens_hsa03420	0.93849464
45	TNF signaling pathway_Homo sapiens_hsa04668	0.93471962
46	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.93441530
47	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.92279998
48	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.91456122
49	Pyruvate metabolism_Homo sapiens_hsa00620	0.90014594
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.88233828
51	HTLV-I infection_Homo sapiens_hsa05166	0.84209442
52	Hepatitis B_Homo sapiens_hsa05161	0.82661099
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.82250639
54	Thyroid cancer_Homo sapiens_hsa05216	0.81406356
55	Asthma_Homo sapiens_hsa05310	0.79426956
56	Phenylalanine metabolism_Homo sapiens_hsa00360	0.77353417
57	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.77175143
58	Viral myocarditis_Homo sapiens_hsa05416	0.76676362
59	Toxoplasmosis_Homo sapiens_hsa05145	0.75606568
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.71564142
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.71491182
62	Acute myeloid leukemia_Homo sapiens_hsa05221	0.70965505
63	Pancreatic cancer_Homo sapiens_hsa05212	0.68972079
64	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.68350989
65	Measles_Homo sapiens_hsa05162	0.67531260
66	p53 signaling pathway_Homo sapiens_hsa04115	0.67218419
67	Spliceosome_Homo sapiens_hsa03040	0.67088212
68	RNA transport_Homo sapiens_hsa03013	0.67063857
69	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.65705972
70	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.65527145
71	MicroRNAs in cancer_Homo sapiens_hsa05206	0.64605643
72	mTOR signaling pathway_Homo sapiens_hsa04150	0.64529911
73	Leishmaniasis_Homo sapiens_hsa05140	0.64326142
74	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.63722391
75	Hepatitis C_Homo sapiens_hsa05160	0.63349176
76	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.62407226
77	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.57954165
78	Fanconi anemia pathway_Homo sapiens_hsa03460	0.57327822
79	Other glycan degradation_Homo sapiens_hsa00511	0.55932570
80	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.55640765
81	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.55130073
82	Lysine degradation_Homo sapiens_hsa00310	0.54023062
83	Legionellosis_Homo sapiens_hsa05134	0.52582093
84	Non-small cell lung cancer_Homo sapiens_hsa05223	0.51922226
85	mRNA surveillance pathway_Homo sapiens_hsa03015	0.49688470
86	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.46774836
87	Insulin resistance_Homo sapiens_hsa04931	0.44672696
88	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.43150632
89	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.42369386
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.37272126
91	Antigen processing and presentation_Homo sapiens_hsa04612	0.35312022
92	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.33797940
93	Insulin signaling pathway_Homo sapiens_hsa04910	0.33308892
94	VEGF signaling pathway_Homo sapiens_hsa04370	0.33237313
95	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.33023132
96	Prion diseases_Homo sapiens_hsa05020	0.32611165
97	Osteoclast differentiation_Homo sapiens_hsa04380	0.32380436
98	Notch signaling pathway_Homo sapiens_hsa04330	0.31794616
99	RNA polymerase_Homo sapiens_hsa03020	0.29666947
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.28216301

C6ORF223

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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