ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of cell aging (GO:0090344)	8.69271618
2	cellular response to ATP (GO:0071318)	8.46491839
3	regulation of skeletal muscle contraction (GO:0014819)	8.39280462
4	GDP-mannose metabolic process (GO:0019673)	7.89648789
5	DNA strand renaturation (GO:0000733)	7.88879709
6	regulation of synapse structural plasticity (GO:0051823)	7.00390896
7	adenosine receptor signaling pathway (GO:0001973)	6.95672397
8	mitotic cell cycle arrest (GO:0071850)	6.39204934
9	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	6.37874143
10	meiotic chromosome segregation (GO:0045132)	6.35275865
11	purinergic nucleotide receptor signaling pathway (GO:0035590)	6.27230317
12	protein carboxylation (GO:0018214)	6.22584582
13	peptidyl-glutamic acid carboxylation (GO:0017187)	6.22584582
14	lens fiber cell differentiation (GO:0070306)	5.94835245
15	rRNA methylation (GO:0031167)	5.67003268
16	regulation of cytokine production involved in inflammatory response (GO:1900015)	5.43141061
17	rRNA modification (GO:0000154)	5.40601155
18	transepithelial transport (GO:0070633)	5.35785928
19	detection of light stimulus involved in sensory perception (GO:0050962)	5.29075143
20	detection of light stimulus involved in visual perception (GO:0050908)	5.29075143
21	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	4.91718880
22	behavioral response to nicotine (GO:0035095)	4.91200391
23	response to ATP (GO:0033198)	4.85239120
24	positive regulation of heat generation (GO:0031652)	4.64674989
25	purine ribonucleotide transport (GO:0015868)	4.61503378
26	estrogen biosynthetic process (GO:0006703)	4.61218845
27	nucleotide transmembrane transport (GO:1901679)	4.60943359
28	purinergic receptor signaling pathway (GO:0035587)	4.59321426
29	adenine nucleotide transport (GO:0051503)	4.56899878
30	nucleoside transmembrane transport (GO:1901642)	4.49063352
31	sensory perception of taste (GO:0050909)	4.44556069
32	positive regulation of protein kinase C signaling (GO:0090037)	4.32764924
33	phosphatidylglycerol biosynthetic process (GO:0006655)	4.29808027
34	melanin biosynthetic process (GO:0042438)	4.19607905
35	regulation of protein kinase A signaling (GO:0010738)	4.08734309
36	regulation of cell aging (GO:0090342)	4.03648691
37	purine deoxyribonucleotide catabolic process (GO:0009155)	3.83755399
38	sulfur amino acid catabolic process (GO:0000098)	3.82049738
39	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	3.82019371
40	secondary metabolite biosynthetic process (GO:0044550)	3.80171221
41	urinary tract smooth muscle contraction (GO:0014848)	3.78219851
42	respiratory chain complex IV assembly (GO:0008535)	3.77817875
43	grooming behavior (GO:0007625)	3.75128802
44	base-excision repair, AP site formation (GO:0006285)	3.74695171
45	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.73367695
46	melanin metabolic process (GO:0006582)	3.70274961
47	cellular anion homeostasis (GO:0030002)	3.67820752
48	peptidyl-glutamic acid modification (GO:0018200)	3.65686072
49	peristalsis (GO:0030432)	3.62899631
50	nucleotide-sugar biosynthetic process (GO:0009226)	3.59179294
51	regulation of heat generation (GO:0031650)	3.57265500
52	UV protection (GO:0009650)	3.55280172
53	sialylation (GO:0097503)	3.53169611
54	regulation of phospholipid biosynthetic process (GO:0071071)	3.44250260
55	purine nucleotide transport (GO:0015865)	3.44047605
56	phosphate ion homeostasis (GO:0055062)	3.42515532
57	trivalent inorganic anion homeostasis (GO:0072506)	3.42515532
58	granulocyte differentiation (GO:0030851)	3.41945166
59	cardiolipin metabolic process (GO:0032048)	3.41277171
60	cytochrome complex assembly (GO:0017004)	3.36579951
61	sphingomyelin metabolic process (GO:0006684)	3.35564280
62	deoxyribonucleotide catabolic process (GO:0009264)	3.33339891
63	protein insertion into membrane (GO:0051205)	3.31562183
64	cilium or flagellum-dependent cell motility (GO:0001539)	3.30327483
65	negative regulation of interleukin-8 production (GO:0032717)	3.29248063
66	neuromuscular synaptic transmission (GO:0007274)	3.23791656
67	positive regulation of TOR signaling (GO:0032008)	3.22551897
68	nucleoside transport (GO:0015858)	3.22044429
69	inositol phosphate dephosphorylation (GO:0046855)	3.20625369
70	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.20625369
71	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.20144918
72	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.20144918
73	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.19151987
74	tRNA modification (GO:0006400)	3.18978942
75	iron-sulfur cluster assembly (GO:0016226)	3.15951856
76	metallo-sulfur cluster assembly (GO:0031163)	3.15951856
77	response to gravity (GO:0009629)	3.14913380
78	deoxyribose phosphate catabolic process (GO:0046386)	3.11523034
79	piRNA metabolic process (GO:0034587)	3.10828989
80	activation of adenylate cyclase activity (GO:0007190)	3.09882201
81	sex determination (GO:0007530)	3.09263031
82	protein K11-linked ubiquitination (GO:0070979)	3.08349596
83	interferon-gamma production (GO:0032609)	3.03389264
84	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.99594207
85	preassembly of GPI anchor in ER membrane (GO:0016254)	2.99538300
86	type B pancreatic cell proliferation (GO:0044342)	2.95919377
87	DNA replication checkpoint (GO:0000076)	2.93497769
88	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	2.92282644
89	regulation of feeding behavior (GO:0060259)	2.91687317
90	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.89332228
91	gonadal mesoderm development (GO:0007506)	2.84456059
92	iron coordination entity transport (GO:1901678)	2.84102654
93	DNA deamination (GO:0045006)	2.83907948
94	inositol phosphate catabolic process (GO:0071545)	2.82328372
95	mannosylation (GO:0097502)	2.79719239
96	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	2.77909909
97	nucleoside bisphosphate biosynthetic process (GO:0033866)	2.77909909
98	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	2.77909909
99	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.75498098
100	C-terminal protein lipidation (GO:0006501)	2.75027540

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_21846776_ChIP-Seq_THP-1_Human	3.88685690
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.22785091
3	* P68_20966046_ChIP-Seq_HELA_Human	3.01640274
4	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.95739653
5	* XRN2_22483619_ChIP-Seq_HELA_Human	2.88533176
6	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.87733459
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.70682589
8	* BCL6_27268052_Chip-Seq_Bcells_Human	2.55382684
9	* LXR_22292898_ChIP-Seq_THP-1_Human	2.48399479
10	* MAF_26560356_Chip-Seq_TH2_Human	2.45028197
11	* E2F1_20622854_ChIP-Seq_HELA_Human	2.44779124
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.39230812
13	* BCOR_27268052_Chip-Seq_Bcells_Human	2.32829477
14	PHF8_20622854_ChIP-Seq_HELA_Human	2.31366434
15	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.30938015
16	CTCF_27219007_Chip-Seq_Bcells_Human	2.19816545
17	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.18113449
18	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.14272338
19	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.13582110
20	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.13264019
21	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	2.09841881
22	RARB_24833708_ChIP-Seq_LIVER_Mouse	2.07663609
23	TET1_21451524_ChIP-Seq_MESCs_Mouse	2.01927051
24	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.99777015
25	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.99189858
26	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.88649033
27	* SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.87195042
28	VDR_24763502_ChIP-Seq_THP-1_Human	1.87007340
29	MAF_26560356_Chip-Seq_TH1_Human	1.85533926
30	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.85295638
31	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.84557407
32	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.83910124
33	CTCF_20526341_ChIP-Seq_ESCs_Human	1.81752931
34	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.81546710
35	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.79651547
36	CTCF_21964334_Chip-Seq_Bcells_Human	1.77970734
37	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.77649690
38	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.74664752
39	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.72515835
40	* YY1_22570637_ChIP-Seq_MALME-3M_Human	1.71062872
41	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.67955889
42	ERA_21632823_ChIP-Seq_H3396_Human	1.67447717
43	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.67131235
44	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.66142082
45	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.65632207
46	RACK7_27058665_Chip-Seq_MCF-7_Human	1.64330881
47	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.63308995
48	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61769841
49	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.61496505
50	GABP_19822575_ChIP-Seq_HepG2_Human	1.60684404
51	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.60413094
52	UTX_26944678_Chip-Seq_JUKART_Human	1.53943042
53	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.53578167
54	SMC4_20622854_ChIP-Seq_HELA_Human	1.51542623
55	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.51281047
56	CIITA_25753668_ChIP-Seq_RAJI_Human	1.47540925
57	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.46548979
58	SA1_27219007_Chip-Seq_Bcells_Human	1.46171673
59	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.46038160
60	DCP1A_22483619_ChIP-Seq_HELA_Human	1.45399026
61	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.42835109
62	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.41186586
63	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.41145872
64	NANOG_20526341_ChIP-Seq_ESCs_Human	1.40719839
65	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.39850407
66	TP53_22127205_ChIP-Seq_IMR90_Human	1.39407846
67	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.36165001
68	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.34927882
69	TAF2_19829295_ChIP-Seq_ESCs_Human	1.33805238
70	P300_27268052_Chip-Seq_Bcells_Human	1.32489145
71	* VDR_23849224_ChIP-Seq_CD4+_Human	1.31081771
72	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.30702220
73	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.27693966
74	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.27504993
75	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.22615227
76	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.22546511
77	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.21854316
78	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.21841340
79	* P53_21459846_ChIP-Seq_SAOS-2_Human	1.21274578
80	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.20288956
81	OCT4_20526341_ChIP-Seq_ESCs_Human	1.16840869
82	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.16644749
83	CREB1_26743006_Chip-Seq_LNCaP_Human	1.16417021
84	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.15278851
85	MYC_19829295_ChIP-Seq_ESCs_Human	1.14236697
86	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.13769592
87	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11429149
88	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.09551806
89	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.08949755
90	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.08736232
91	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.08457262
92	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.08319516
93	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.07944636
94	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.07906662
95	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.07276888
96	TP53_22573176_ChIP-Seq_HFKS_Human	1.07014808
97	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.05847762
98	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.05732706
99	KDM2B_26808549_Chip-Seq_DND41_Human	1.05019976
100	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.03060859

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	7.35947764
2	MP0001986_abnormal_taste_sensitivity	6.42352723
3	MP0005423_abnormal_somatic_nervous	6.13527394
4	MP0005174_abnormal_tail_pigmentation	5.67821723
5	MP0003136_yellow_coat_color	5.33827876
6	MP0008875_abnormal_xenobiotic_pharmacok	3.23370343
7	MP0001968_abnormal_touch/_nociception	3.22672133
8	MP0001188_hyperpigmentation	2.95098104
9	MP0002638_abnormal_pupillary_reflex	2.55366451
10	MP0001756_abnormal_urination	2.55278092
11	MP0005083_abnormal_biliary_tract	2.53443472
12	MP0002736_abnormal_nociception_after	2.47094921
13	MP0001502_abnormal_circadian_rhythm	2.34128853
14	MP0000751_myopathy	2.26681533
15	MP0002160_abnormal_reproductive_system	2.06354515
16	MP0005409_darkened_coat_color	2.03773942
17	MP0000015_abnormal_ear_pigmentation	1.99186647
18	MP0004381_abnormal_hair_follicle	1.90299523
19	MP0000750_abnormal_muscle_regeneration	1.87055900
20	MP0001661_extended_life_span	1.85052091
21	MP0005551_abnormal_eye_electrophysiolog	1.73471137
22	MP0005332_abnormal_amino_acid	1.61673165
23	MP0002735_abnormal_chemical_nociception	1.60200810
24	MP0000538_abnormal_urinary_bladder	1.57408055
25	MP0001905_abnormal_dopamine_level	1.53152574
26	MP0005330_cardiomyopathy	1.47054281
27	MP0000013_abnormal_adipose_tissue	1.44875814
28	MP0003806_abnormal_nucleotide_metabolis	1.42193758
29	MP0005410_abnormal_fertilization	1.42035090
30	MP0001919_abnormal_reproductive_system	1.34490062
31	MP0005084_abnormal_gallbladder_morpholo	1.29696619
32	MP0010386_abnormal_urinary_bladder	1.25775057
33	MP0005253_abnormal_eye_physiology	1.24297290
34	MP0004130_abnormal_muscle_cell	1.24156441
35	MP0002909_abnormal_adrenal_gland	1.22599927
36	MP0003011_delayed_dark_adaptation	1.19736177
37	MP0003453_abnormal_keratinocyte_physiol	1.14278497
38	MP0004019_abnormal_vitamin_homeostasis	1.10378801
39	MP0001765_abnormal_ion_homeostasis	1.10376168
40	MP0005389_reproductive_system_phenotype	1.09630788
41	MP0004043_abnormal_pH_regulation	1.08505773
42	MP0001970_abnormal_pain_threshold	1.08043312
43	MP0003137_abnormal_impulse_conducting	1.04611818
44	MP0005365_abnormal_bile_salt	1.02717024
45	MP0005584_abnormal_enzyme/coenzyme_acti	1.00181126
46	MP0005501_abnormal_skin_physiology	0.85380265
47	MP0002933_joint_inflammation	0.84541776
48	MP0006276_abnormal_autonomic_nervous	0.83836135
49	MP0003878_abnormal_ear_physiology	0.82474884
50	MP0005377_hearing/vestibular/ear_phenot	0.82474884
51	MP0001664_abnormal_digestion	0.82161710
52	MP0001324_abnormal_eye_pigmentation	0.81958765
53	MP0000358_abnormal_cell_content/	0.81437609
54	MP0006036_abnormal_mitochondrial_physio	0.80988330
55	MP0003111_abnormal_nucleus_morphology	0.79891964
56	MP0009643_abnormal_urine_homeostasis	0.77530302
57	MP0002254_reproductive_system_inflammat	0.76940223
58	MP0000003_abnormal_adipose_tissue	0.76699621
59	MP0000367_abnormal_coat/_hair	0.71342095
60	MP0000470_abnormal_stomach_morphology	0.71155841
61	MP0004215_abnormal_myocardial_fiber	0.69166983
62	MP0000747_muscle_weakness	0.67142330
63	MP0001873_stomach_inflammation	0.65609832
64	MP0002928_abnormal_bile_duct	0.57398107
65	MP0002210_abnormal_sex_determination	0.57209838
66	MP0004142_abnormal_muscle_tone	0.55360628
67	MP0003448_altered_tumor_morphology	0.54416347
68	MP0006082_CNS_inflammation	0.53319340
69	MP0002136_abnormal_kidney_physiology	0.52082620
70	MP0001958_emphysema	0.52020456
71	MP0005058_abnormal_lysosome_morphology	0.51901831
72	MP0001191_abnormal_skin_condition	0.50892055
73	MP0008872_abnormal_physiological_respon	0.49776895
74	MP0002019_abnormal_tumor_incidence	0.48988774
75	MP0010771_integument_phenotype	0.46670404
76	MP0002277_abnormal_respiratory_mucosa	0.45451789
77	MP0002118_abnormal_lipid_homeostasis	0.45025652
78	MP0005195_abnormal_posterior_eye	0.44384371
79	MP0002075_abnormal_coat/hair_pigmentati	0.42135084
80	MP0001764_abnormal_homeostasis	0.41574227
81	MP0002572_abnormal_emotion/affect_behav	0.40979249
82	MP0004924_abnormal_behavior	0.40420396
83	MP0005386_behavior/neurological_phenoty	0.40420396
84	MP0000026_abnormal_inner_ear	0.39947063
85	MP0005257_abnormal_intraocular_pressure	0.39544131
86	MP0005448_abnormal_energy_balance	0.39522659
87	MP0009931_abnormal_skin_appearance	0.39363049
88	MP0003635_abnormal_synaptic_transmissio	0.39337339
89	MP0008789_abnormal_olfactory_epithelium	0.39169641
90	MP0009745_abnormal_behavioral_response	0.38713844
91	MP0006035_abnormal_mitochondrial_morpho	0.38245182
92	MP0005535_abnormal_body_temperature	0.38080952
93	MP0003698_abnormal_male_reproductive	0.37992937
94	MP0005636_abnormal_mineral_homeostasis	0.37332321
95	MP0005220_abnormal_exocrine_pancreas	0.37189003
96	MP0002095_abnormal_skin_pigmentation	0.36581478
97	MP0009384_cardiac_valve_regurgitation	0.35261546
98	MP0000230_abnormal_systemic_arterial	0.35134010
99	MP0008874_decreased_physiological_sensi	0.34161595
100	MP0003880_abnormal_central_pattern	0.34016867

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Testicular atrophy (HP:0000029)	6.37032797
2	Rib fusion (HP:0000902)	6.05733644
3	Attenuation of retinal blood vessels (HP:0007843)	5.49171223
4	Dyschromatopsia (HP:0007641)	5.29564799
5	Rectovaginal fistula (HP:0000143)	5.17644629
6	Rectal fistula (HP:0100590)	5.17644629
7	Mesangial abnormality (HP:0001966)	5.10173792
8	Poikiloderma (HP:0001029)	4.84382318
9	Increased hepatocellular lipid droplets (HP:0006565)	4.77779056
10	Vaginal fistula (HP:0004320)	4.67387761
11	Congenital stationary night blindness (HP:0007642)	4.66741616
12	Renal Fanconi syndrome (HP:0001994)	4.60665423
13	Intestinal fistula (HP:0100819)	4.59075172
14	Lipid accumulation in hepatocytes (HP:0006561)	4.52583770
15	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	4.51302726
16	Facial diplegia (HP:0001349)	4.27846842
17	Popliteal pterygium (HP:0009756)	4.16350091
18	Thin bony cortex (HP:0002753)	4.02375440
19	Akinesia (HP:0002304)	3.99929439
20	Abnormality of the intrinsic pathway (HP:0010989)	3.97157609
21	Annular pancreas (HP:0001734)	3.93064459
22	Facial hemangioma (HP:0000329)	3.80382986
23	Bony spicule pigmentary retinopathy (HP:0007737)	3.79467697
24	Prolonged partial thromboplastin time (HP:0003645)	3.75405593
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.69156128
26	Joint hemorrhage (HP:0005261)	3.68465364
27	Fetal akinesia sequence (HP:0001989)	3.66331693
28	Chorioretinal atrophy (HP:0000533)	3.62545569
29	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.54630485
30	Aplasia of the musculature (HP:0100854)	3.50224513
31	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.48618578
32	Choroideremia (HP:0001139)	3.45022796
33	Increased intramyocellular lipid droplets (HP:0012240)	3.44434776
34	Hypoalbuminemia (HP:0003073)	3.40360506
35	Abnormal albumin level (HP:0012116)	3.40360506
36	Turricephaly (HP:0000262)	3.34629290
37	Ulnar bowing (HP:0003031)	3.30828574
38	Squamous cell carcinoma (HP:0002860)	3.28256172
39	Delayed epiphyseal ossification (HP:0002663)	3.26117366
40	Exertional dyspnea (HP:0002875)	3.25896210
41	Decreased central vision (HP:0007663)	3.21572725
42	Increased muscle lipid content (HP:0009058)	3.19466427
43	Abnormality of placental membranes (HP:0011409)	3.17308018
44	Amniotic constriction ring (HP:0009775)	3.17308018
45	Hemorrhage of the eye (HP:0011885)	3.10017168
46	Coronal craniosynostosis (HP:0004440)	3.01191261
47	Atrioventricular block (HP:0001678)	2.95052188
48	Abnormality of the costochondral junction (HP:0000919)	2.94651753
49	Patellar aplasia (HP:0006443)	2.94550619
50	Myotonia (HP:0002486)	2.94424256
51	Enlarged epiphyses (HP:0010580)	2.80822346
52	Abnormality of renal resorption (HP:0011038)	2.80780912
53	Hypophosphatemic rickets (HP:0004912)	2.79734543
54	Aplasia/Hypoplasia of the patella (HP:0006498)	2.77184761
55	Anteriorly placed anus (HP:0001545)	2.68889915
56	Absent thumb (HP:0009777)	2.67670917
57	Respiratory difficulties (HP:0002880)	2.59780433
58	Short chin (HP:0000331)	2.58349919
59	Neonatal respiratory distress (HP:0002643)	2.52761754
60	Premature graying of hair (HP:0002216)	2.48063679
61	Abnormal urine phosphate concentration (HP:0012599)	2.43228849
62	Type 2 muscle fiber atrophy (HP:0003554)	2.43177665
63	Widely patent fontanelles and sutures (HP:0004492)	2.40727981
64	Neonatal onset (HP:0003623)	2.32789098
65	Polydipsia (HP:0001959)	2.31879586
66	Abnormal drinking behavior (HP:0030082)	2.31879586
67	Mitochondrial inheritance (HP:0001427)	2.31079920
68	Muscle fiber atrophy (HP:0100295)	2.29001246
69	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.28786418
70	Joint stiffness (HP:0001387)	2.26750727
71	Zonular cataract (HP:0010920)	2.22568666
72	Pendular nystagmus (HP:0012043)	2.19711222
73	Abnormal epiphyseal ossification (HP:0010656)	2.17300550
74	Capillary hemangiomas (HP:0005306)	2.08612666
75	Hypoplasia of the pons (HP:0012110)	2.07610827
76	Diminished movement (HP:0002374)	2.06675654
77	Narrow nasal bridge (HP:0000446)	2.04140151
78	Basal cell carcinoma (HP:0002671)	2.02934629
79	Choanal stenosis (HP:0000452)	2.02825379
80	Malignant hyperthermia (HP:0002047)	2.01629285
81	Glycosuria (HP:0003076)	2.00759605
82	Abnormality of urine glucose concentration (HP:0011016)	2.00759605
83	Abnormality of the common coagulation pathway (HP:0010990)	2.00230069
84	Flat occiput (HP:0005469)	1.99190286
85	Increased CSF lactate (HP:0002490)	1.98768864
86	Birth length less than 3rd percentile (HP:0003561)	1.95100666
87	Male infertility (HP:0003251)	1.94477626
88	Bowing of the arm (HP:0006488)	1.91534527
89	Bowed forearm bones (HP:0003956)	1.91534527
90	Heart block (HP:0012722)	1.89026233
91	Epiphyseal stippling (HP:0010655)	1.88798799
92	Hepatocellular necrosis (HP:0001404)	1.86752968
93	Renal tubular dysfunction (HP:0000124)	1.85865994
94	Abnormality of the pons (HP:0007361)	1.85562231
95	Hyperphosphaturia (HP:0003109)	1.82721446
96	Optic disc pallor (HP:0000543)	1.81714865
97	Reduced antithrombin III activity (HP:0001976)	1.81170976
98	Macular degeneration (HP:0000608)	1.80056953
99	Abnormality of the neuromuscular junction (HP:0003398)	1.79926462
100	Fatigable weakness (HP:0003473)	1.79926462

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	9.72609560
2	WNK4	4.58781101
3	MUSK	3.56707385
4	TESK2	3.14118565
5	TLK1	2.86806126
6	STK16	2.86697037
7	BLK	2.56322040
8	ZAK	2.55459873
9	ADRBK2	2.35605817
10	ADRBK1	1.73314687
11	GRK6	1.67111746
12	BCKDK	1.66077788
13	MAP4K2	1.57659281
14	SIK2	1.53641833
15	TRIM28	1.51768391
16	NUAK1	1.43925951
17	DYRK1B	1.34338953
18	CCNB1	1.20148329
19	PIM2	1.15477451
20	DYRK2	1.13200858
21	CSK	1.12083330
22	VRK2	1.09048257
23	MAP3K11	1.07559405
24	IRAK2	0.99329499
25	TBK1	0.91510251
26	DAPK2	0.88757991
27	ZAP70	0.88104881
28	WNK3	0.86447039
29	GRK1	0.85854398
30	CDK15	0.85630900
31	BMPR1B	0.85375418
32	MAP2K6	0.83710264
33	RPS6KA5	0.83447838
34	CDK11A	0.82955452
35	CDK18	0.82458797
36	PDK2	0.82366712
37	WNK1	0.81775331
38	DAPK1	0.81731699
39	ACVR1B	0.81383957
40	TAOK3	0.80100181
41	MAP2K3	0.79937750
42	STK39	0.78526765
43	OXSR1	0.78190062
44	IKBKE	0.75421798
45	CSNK1G3	0.75357491
46	CAMKK2	0.73342030
47	CDK14	0.71179234
48	PDPK1	0.71158790
49	PAK1	0.71112079
50	IKBKB	0.70341754
51	ARAF	0.69759344
52	DYRK3	0.68910343
53	CSNK1A1L	0.68369289
54	PRKCH	0.68307283
55	PRKD1	0.67411788
56	AURKA	0.67111171
57	PINK1	0.63073110
58	MAP4K1	0.62850372
59	NME2	0.62144058
60	LIMK1	0.62114599
61	STK11	0.56228530
62	PRKCQ	0.54814059
63	VRK1	0.54514251
64	FRK	0.54432103
65	CSNK1D	0.54329334
66	CSNK1G2	0.53973102
67	BMX	0.52810840
68	PLK1	0.50806592
69	MAPK13	0.50528379
70	ERN1	0.49911758
71	TESK1	0.49441445
72	MAP2K7	0.48453780
73	PRKD2	0.46713693
74	CSNK1G1	0.45829327
75	MAPK11	0.42480727
76	FES	0.41865351
77	TIE1	0.41203714
78	KDR	0.41202116
79	DAPK3	0.41148534
80	PHKG2	0.41004152
81	PHKG1	0.41004152
82	SIK3	0.40445407
83	ABL2	0.38295034
84	RPS6KA6	0.37288128
85	RPS6KA2	0.37282050
86	CHEK2	0.36612654
87	ATR	0.34724354
88	PRKCG	0.33859795
89	PRKACA	0.33392242
90	PRKCD	0.32734200
91	LYN	0.31081118
92	SIK1	0.30391120
93	MAPK12	0.29402232
94	MAPKAPK3	0.28746260
95	TXK	0.28118945
96	CDK4	0.27619349
97	SYK	0.27022391
98	PRKCA	0.26908494
99	TAF1	0.26889647
100	TAOK2	0.25119578

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	7.09988978
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	7.01152593
3	Sulfur relay system_Homo sapiens_hsa04122	5.17504305
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.40865163
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.26806272
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.87763564
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.61604310
8	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.45310549
9	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.99719337
10	RNA polymerase_Homo sapiens_hsa03020	1.87218357
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.74509642
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.66490527
13	Circadian rhythm_Homo sapiens_hsa04710	1.65040385
14	Sphingolipid metabolism_Homo sapiens_hsa00600	1.64839239
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.55015082
16	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.47531829
17	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.31187954
18	Parkinsons disease_Homo sapiens_hsa05012	1.29830001
19	Taste transduction_Homo sapiens_hsa04742	1.26237559
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.25968568
21	Phototransduction_Homo sapiens_hsa04744	1.21680705
22	Nicotine addiction_Homo sapiens_hsa05033	1.20807190
23	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.20460565
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.05062932
25	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.01943275
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94215373
27	Huntingtons disease_Homo sapiens_hsa05016	0.92766256
28	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91646807
29	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89992894
30	Basal transcription factors_Homo sapiens_hsa03022	0.88537656
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.87131987
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.85806235
33	Primary immunodeficiency_Homo sapiens_hsa05340	0.85158970
34	Glutathione metabolism_Homo sapiens_hsa00480	0.81593608
35	Base excision repair_Homo sapiens_hsa03410	0.80850616
36	Alzheimers disease_Homo sapiens_hsa05010	0.76654116
37	Lysosome_Homo sapiens_hsa04142	0.72018108
38	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.70386755
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.70237573
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69514196
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69034679
42	Pyruvate metabolism_Homo sapiens_hsa00620	0.68128946
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.67534684
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.67315117
45	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.67142585
46	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.61824158
47	Sulfur metabolism_Homo sapiens_hsa00920	0.59379568
48	Metabolic pathways_Homo sapiens_hsa01100	0.57897800
49	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.56108927
50	Linoleic acid metabolism_Homo sapiens_hsa00591	0.55907610
51	Homologous recombination_Homo sapiens_hsa03440	0.55606035
52	Cocaine addiction_Homo sapiens_hsa05030	0.55462734
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.54084042
54	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.52927247
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49092534
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48554613
57	Purine metabolism_Homo sapiens_hsa00230	0.48378625
58	Cardiac muscle contraction_Homo sapiens_hsa04260	0.47600826
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46460453
60	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.44939098
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.44062206
62	Proteasome_Homo sapiens_hsa03050	0.43069365
63	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.41722429
64	Allograft rejection_Homo sapiens_hsa05330	0.41396679
65	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.40614848
66	Peroxisome_Homo sapiens_hsa04146	0.39893536
67	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38993527
68	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.37893998
69	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.36574384
70	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.36343927
71	Ribosome_Homo sapiens_hsa03010	0.34652046
72	Asthma_Homo sapiens_hsa05310	0.33874404
73	Regulation of autophagy_Homo sapiens_hsa04140	0.31635428
74	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.30975530
75	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.30344569
76	Alcoholism_Homo sapiens_hsa05034	0.28700487
77	Type I diabetes mellitus_Homo sapiens_hsa04940	0.27780235
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.27276006
79	Morphine addiction_Homo sapiens_hsa05032	0.27146749
80	Graft-versus-host disease_Homo sapiens_hsa05332	0.21887728
81	Nitrogen metabolism_Homo sapiens_hsa00910	0.21670523
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.21036461
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.19765759
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.19258189
85	Other glycan degradation_Homo sapiens_hsa00511	0.18991407
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.18877766
87	Ether lipid metabolism_Homo sapiens_hsa00565	0.18060865
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.17931101
89	Mineral absorption_Homo sapiens_hsa04978	0.16908273
90	One carbon pool by folate_Homo sapiens_hsa00670	0.15702703
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.15682944
92	Endocytosis_Homo sapiens_hsa04144	0.14445291
93	Fatty acid degradation_Homo sapiens_hsa00071	0.12955165
94	RNA degradation_Homo sapiens_hsa03018	0.09830763
95	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.09758926
96	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.09533695
97	Protein export_Homo sapiens_hsa03060	0.08675514
98	mTOR signaling pathway_Homo sapiens_hsa04150	0.08172466
99	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.08034819
100	Melanogenesis_Homo sapiens_hsa04916	0.07691237

C6ORF226

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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