C6ORF25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)8.50437768
2protein neddylation (GO:0045116)7.40217651
3neutrophil activation involved in immune response (GO:0002283)7.09178685
4regulation of platelet aggregation (GO:0090330)6.11649600
5regulation of platelet activation (GO:0010543)5.90020132
6blood coagulation, intrinsic pathway (GO:0007597)5.71693265
7platelet aggregation (GO:0070527)5.42833074
8leukocyte migration involved in inflammatory response (GO:0002523)5.12325420
9positive regulation of mast cell activation (GO:0033005)4.81764607
10adenosine receptor signaling pathway (GO:0001973)4.75718126
11angiogenesis involved in wound healing (GO:0060055)4.68757885
12positive regulation of endothelial cell differentiation (GO:0045603)4.68396663
13negative regulation of thymocyte apoptotic process (GO:0070244)4.62592062
14negative regulation of platelet activation (GO:0010544)4.62551685
15regulation of integrin-mediated signaling pathway (GO:2001044)4.61965393
16negative regulation of homotypic cell-cell adhesion (GO:0034111)4.61715925
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.58991887
18lipoxygenase pathway (GO:0019372)4.57775149
19purinergic nucleotide receptor signaling pathway (GO:0035590)4.55297983
20negative regulation of norepinephrine secretion (GO:0010700)4.52199605
21negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.45813477
22neutrophil activation (GO:0042119)4.42968583
23regulation of integrin activation (GO:0033623)4.39641612
24negative regulation of heart rate (GO:0010459)4.39586799
25megakaryocyte development (GO:0035855)4.29962007
26G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.29747419
27positive regulation of cAMP-mediated signaling (GO:0043950)4.02590770
28regulation of lipoprotein metabolic process (GO:0050746)3.95073389
29fusion of sperm to egg plasma membrane (GO:0007342)3.86673852
30polyamine biosynthetic process (GO:0006596)3.83693790
31granulocyte activation (GO:0036230)3.81513267
32platelet degranulation (GO:0002576)3.76845067
33homotypic cell-cell adhesion (GO:0034109)3.76760775
34negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.75267718
35platelet formation (GO:0030220)3.70306023
36regulation of MHC class II biosynthetic process (GO:0045346)3.67809306
37negative regulation of response to food (GO:0032096)3.65524045
38negative regulation of appetite (GO:0032099)3.65524045
39purinergic receptor signaling pathway (GO:0035587)3.65450934
40low-density lipoprotein particle remodeling (GO:0034374)3.62635423
41regulation of Golgi to plasma membrane protein transport (GO:0042996)3.60548620
42positive regulation of macrophage differentiation (GO:0045651)3.54436036
43platelet activation (GO:0030168)3.53447132
44negative regulation of T-helper cell differentiation (GO:0045623)3.52749988
45negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.52749988
46regulation of homotypic cell-cell adhesion (GO:0034110)3.51210042
47regulation of memory T cell differentiation (GO:0043380)3.49608390
48autophagic vacuole fusion (GO:0000046)3.46011652
49regulation of mast cell activation (GO:0033003)3.42160090
50positive regulation of blood coagulation (GO:0030194)3.41189404
51positive regulation of hemostasis (GO:1900048)3.41189404
52regulation of macrophage derived foam cell differentiation (GO:0010743)3.39317429
53positive regulation of granulocyte differentiation (GO:0030854)3.34937724
54negative regulation of protein localization to cell surface (GO:2000009)3.33847678
55regulation of endothelial cell differentiation (GO:0045601)3.30507064
56negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.27133455
57regulation of female receptivity (GO:0045924)3.24292950
58negative regulation of T cell apoptotic process (GO:0070233)3.21895997
59positive regulation of mast cell activation involved in immune response (GO:0033008)3.19112201
60positive regulation of mast cell degranulation (GO:0043306)3.19112201
61leukocyte degranulation (GO:0043299)3.18038092
62termination of G-protein coupled receptor signaling pathway (GO:0038032)3.17400035
63positive regulation of systemic arterial blood pressure (GO:0003084)3.16897482
64positive regulation of Rho protein signal transduction (GO:0035025)3.13911366
65regulation of mast cell degranulation (GO:0043304)3.13624218
66negative regulation of neural precursor cell proliferation (GO:2000178)3.13350018
67regulation of norepinephrine secretion (GO:0014061)3.09819070
68monoamine transport (GO:0015844)3.08693018
69regulation of mast cell activation involved in immune response (GO:0033006)3.07998071
70mitochondrial calcium ion transport (GO:0006851)3.06101873
71G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.04558307
72positive regulation of coagulation (GO:0050820)3.03975332
73negative regulation of heart contraction (GO:0045822)3.03972700
74termination of signal transduction (GO:0023021)3.03808899
75cellular biogenic amine biosynthetic process (GO:0042401)3.03691427
76positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.03140939
77cyclooxygenase pathway (GO:0019371)3.01526423
78pyrimidine nucleoside catabolic process (GO:0046135)2.99081763
79endothelium development (GO:0003158)2.98720845
80regulation of regulatory T cell differentiation (GO:0045589)2.97498991
81long-chain fatty acid biosynthetic process (GO:0042759)2.97217753
82fatty acid elongation (GO:0030497)2.95630067
83phagocytosis, engulfment (GO:0006911)2.94900504
84negative regulation of calcium ion transport into cytosol (GO:0010523)2.94157789
85regulation of megakaryocyte differentiation (GO:0045652)2.87946942
86amine biosynthetic process (GO:0009309)2.87559954
87plasma membrane fusion (GO:0045026)2.83943506
88regulation of hemostasis (GO:1900046)2.83427461
89regulation of blood coagulation (GO:0030193)2.83427461
90dopamine transport (GO:0015872)2.82250460
91regulation of T-helper 1 cell differentiation (GO:0045625)2.82018168
92Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81843550
93regulation of inositol phosphate biosynthetic process (GO:0010919)2.79742759
94negative regulation of catecholamine secretion (GO:0033604)2.79114713
95beta-amyloid metabolic process (GO:0050435)2.77420491
96relaxation of smooth muscle (GO:0044557)2.76481680
97superoxide anion generation (GO:0042554)2.76171623
98female mating behavior (GO:0060180)2.75389522
99regulation of mitochondrial depolarization (GO:0051900)2.74934951
100organelle membrane fusion (GO:0090174)2.72995204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.61570599
2SCL_19346495_ChIP-Seq_HPC-7_Human4.60398415
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.35281471
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.26224065
5GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.16990482
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.14411282
7GATA1_19941826_ChIP-Seq_K562_Human2.97172242
8LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.89084824
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.64011857
10EZH2_22144423_ChIP-Seq_EOC_Human2.61783255
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.53321753
12GATA1_19941827_ChIP-Seq_MEL_Mouse2.42679851
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42671502
14GATA2_19941826_ChIP-Seq_K562_Human2.42550662
15GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.25701330
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24182104
17SPI1_23127762_ChIP-Seq_K562_Human2.20766278
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.17430460
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.13668673
20GBX2_23144817_ChIP-Seq_PC3_Human2.12085646
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.11569810
22GATA2_21666600_ChIP-Seq_HMVEC_Human2.02704443
23GATA1_22025678_ChIP-Seq_K562_Human2.02508576
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.96296714
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95904126
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.94596996
27TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.91655946
28HTT_18923047_ChIP-ChIP_STHdh_Human1.87142986
29GATA1_22383799_ChIP-Seq_G1ME_Mouse1.86615533
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.85518745
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.83134572
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.72822227
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.68504089
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.68012469
35VDR_22108803_ChIP-Seq_LS180_Human1.61740685
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.57419495
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56554236
38RUNX_20019798_ChIP-Seq_JUKART_Human1.48223928
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46367218
40TAF15_26573619_Chip-Seq_HEK293_Human1.44319134
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43546868
42GATA1_19941827_ChIP-Seq_MEL86_Mouse1.42416785
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42358296
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37699276
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37621568
46KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.33262224
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32320389
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29864262
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.21844917
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21742364
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.20920685
52SALL4_22934838_ChIP-ChIP_CD34+_Human1.17186512
53EWS_26573619_Chip-Seq_HEK293_Human1.15930242
54GATA3_26560356_Chip-Seq_TH2_Human1.15117578
55SPI1_23547873_ChIP-Seq_NB4_Human1.14009718
56GATA3_27048872_Chip-Seq_THYMUS_Human1.13994375
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13266036
58IRF1_19129219_ChIP-ChIP_H3396_Human1.12746953
59ETS1_22383799_ChIP-Seq_G1ME_Mouse1.11586904
60SPI1_20517297_ChIP-Seq_HL60_Human1.09254156
61STAT1_20625510_ChIP-Seq_HELA_Human1.07371677
62MYB_26560356_Chip-Seq_TH2_Human1.07116685
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06788840
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05391650
65PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03852919
66NANOG_20526341_ChIP-Seq_ESCs_Human1.01098221
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00756579
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00703360
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00703360
70IGF1R_20145208_ChIP-Seq_DFB_Human1.00127599
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99790684
72FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97355965
73STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96991032
74NANOG_19829295_ChIP-Seq_ESCs_Human0.96033032
75SOX2_19829295_ChIP-Seq_ESCs_Human0.96033032
76ER_23166858_ChIP-Seq_MCF-7_Human0.94528816
77AR_20517297_ChIP-Seq_VCAP_Human0.93273512
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93138836
79SMRT_27268052_Chip-Seq_Bcells_Human0.92685907
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91897956
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91809218
82CEBPB_22108803_ChIP-Seq_LS180_Human0.89369303
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89103153
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.87229730
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87229730
86BCAT_22108803_ChIP-Seq_LS180_Human0.86638606
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86003750
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.84859395
89ERG_20517297_ChIP-Seq_VCAP_Human0.84587171
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84285477
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83494471
92AR_25329375_ChIP-Seq_VCAP_Human0.82859570
93TDRD3_21172665_ChIP-Seq_MCF-7_Human0.82243666
94SMAD4_21799915_ChIP-Seq_A2780_Human0.81497854
95NCOR1_26117541_ChIP-Seq_K562_Human0.81480026
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81404862
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80486992
98UTX_26944678_Chip-Seq_JUKART_Human0.79755331
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.79646941
100LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79396100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.31946467
2MP0008004_abnormal_stomach_pH5.08257794
3MP0003724_increased_susceptibility_to4.02920294
4MP0000465_gastrointestinal_hemorrhage3.97038166
5MP0001835_abnormal_antigen_presentation2.58546770
6MP0004510_myositis2.53588321
7MP0003303_peritoneal_inflammation2.41623460
8MP0002736_abnormal_nociception_after2.30214859
9MP0005083_abnormal_biliary_tract2.24259986
10MP0000230_abnormal_systemic_arterial2.14663286
11MP0000343_altered_response_to2.03664805
12MP0004084_abnormal_cardiac_muscle2.01097330
13MP0008775_abnormal_heart_ventricle1.92606434
14MP0005084_abnormal_gallbladder_morpholo1.92595392
15MP0005410_abnormal_fertilization1.91998960
16MP0005646_abnormal_pituitary_gland1.91608596
17MP0005167_abnormal_blood-brain_barrier1.89520952
18MP0002148_abnormal_hypersensitivity_rea1.86918161
19MP0008872_abnormal_physiological_respon1.86091896
20MP0005671_abnormal_response_to1.76713431
21MP0001968_abnormal_touch/_nociception1.75788880
22MP0005000_abnormal_immune_tolerance1.65252471
23MP0003638_abnormal_response/metabolism_1.64233495
24MP0001545_abnormal_hematopoietic_system1.57920609
25MP0005397_hematopoietic_system_phenotyp1.57920609
26MP0010155_abnormal_intestine_physiology1.57021446
27MP0002398_abnormal_bone_marrow1.53156161
28MP0003436_decreased_susceptibility_to1.52691110
29MP0002132_abnormal_respiratory_system1.47561743
30MP0003828_pulmonary_edema1.47362549
31MP0002733_abnormal_thermal_nociception1.46050275
32MP0001851_eye_inflammation1.44273996
33MP0003566_abnormal_cell_adhesion1.41464178
34MP0001663_abnormal_digestive_system1.37808070
35MP0001800_abnormal_humoral_immune1.36655037
36MP0004130_abnormal_muscle_cell1.35720504
37MP0002723_abnormal_immune_serum1.35132199
38MP0004036_abnormal_muscle_relaxation1.34650431
39MP0009764_decreased_sensitivity_to1.27035687
40MP0003879_abnormal_hair_cell1.26368615
41MP0002452_abnormal_antigen_presenting1.24752439
42MP0001879_abnormal_lymphatic_vessel1.21604693
43MP0001533_abnormal_skeleton_physiology1.20814207
44MP0000249_abnormal_blood_vessel1.20454241
45MP0000689_abnormal_spleen_morphology1.20366529
46MP0009763_increased_sensitivity_to1.17354608
47MP0006276_abnormal_autonomic_nervous1.15192489
48MP0004947_skin_inflammation1.15042759
49MP0003866_abnormal_defecation1.13077815
50MP0002420_abnormal_adaptive_immunity1.12475409
51MP0001819_abnormal_immune_cell1.10936185
52MP0002429_abnormal_blood_cell1.10503946
53MP0010329_abnormal_lipoprotein_level1.04881531
54MP0000015_abnormal_ear_pigmentation1.03666835
55MP0001970_abnormal_pain_threshold1.02333348
56MP0002419_abnormal_innate_immunity1.01862616
57MP0002722_abnormal_immune_system1.01053816
58MP0005387_immune_system_phenotype1.00646975
59MP0001790_abnormal_immune_system1.00646975
60MP0009765_abnormal_xenobiotic_induced0.98631430
61MP0005025_abnormal_response_to0.97790705
62MP0003656_abnormal_erythrocyte_physiolo0.97667012
63MP0005058_abnormal_lysosome_morphology0.97595659
64MP0000716_abnormal_immune_system0.97198579
65MP0004215_abnormal_myocardial_fiber0.95849730
66MP0001765_abnormal_ion_homeostasis0.95563180
67MP0003718_maternal_effect0.95239903
68MP0005174_abnormal_tail_pigmentation0.94571161
69MP0001845_abnormal_inflammatory_respons0.93579168
70MP0000685_abnormal_immune_system0.93215065
71MP0009642_abnormal_blood_homeostasis0.93196734
72MP0005535_abnormal_body_temperature0.91094108
73MP0004142_abnormal_muscle_tone0.90485944
74MP0002735_abnormal_chemical_nociception0.88408577
75MP0006054_spinal_hemorrhage0.87925565
76MP0008874_decreased_physiological_sensi0.87828281
77MP0009333_abnormal_splenocyte_physiolog0.87823737
78MP0009697_abnormal_copulation0.86137788
79MP0006036_abnormal_mitochondrial_physio0.85779559
80MP0004484_altered_response_of0.85456724
81MP0001664_abnormal_digestion0.84742311
82MP0005381_digestive/alimentary_phenotyp0.80660892
83MP0002653_abnormal_ependyma_morphology0.79929091
84MP0005165_increased_susceptibility_to0.76946776
85MP0003300_gastrointestinal_ulcer0.76122060
86MP0004808_abnormal_hematopoietic_stem0.74844343
87MP0003011_delayed_dark_adaptation0.67050676
88MP0009785_altered_susceptibility_to0.65592451
89MP0001756_abnormal_urination0.64523418
90MP0000858_altered_metastatic_potential0.63377818
91MP0004147_increased_porphyrin_level0.63271430
92MP0000703_abnormal_thymus_morphology0.62179169
93MP0002118_abnormal_lipid_homeostasis0.61938411
94MP0001544_abnormal_cardiovascular_syste0.61734685
95MP0005385_cardiovascular_system_phenoty0.61734685
96MP0004085_abnormal_heartbeat0.60159130
97MP0002405_respiratory_system_inflammati0.59916158
98MP0006035_abnormal_mitochondrial_morpho0.58715867
99MP0003186_abnormal_redox_activity0.58514055
100MP0002998_abnormal_bone_remodeling0.57881523

Predicted human phenotypes

RankGene SetZ-score
1Abnormal platelet volume (HP:0011876)9.83545586
2Purpura (HP:0000979)8.84532805
3Epistaxis (HP:0000421)7.60851151
4Gingival bleeding (HP:0000225)6.79218778
5Impaired platelet aggregation (HP:0003540)5.59095711
6Abnormal platelet function (HP:0011869)5.59095711
7Hyperlipoproteinemia (HP:0010980)5.10706757
8Poikilocytosis (HP:0004447)4.15380951
9Spontaneous hematomas (HP:0007420)4.10601448
10Acanthocytosis (HP:0001927)3.94994365
11Abnormality of the heme biosynthetic pathway (HP:0010472)3.65878777
12Dyschromatopsia (HP:0007641)3.64280030
13Bruising susceptibility (HP:0000978)3.35137971
14Abnormal pupillary function (HP:0007686)3.31040765
15Stomatitis (HP:0010280)3.22061752
16Conjunctival telangiectasia (HP:0000524)3.08002936
17Abnormality of the common coagulation pathway (HP:0010990)2.97241007
18Abnormality of the vasculature of the conjunctiva (HP:0008054)2.85957300
19Paralysis (HP:0003470)2.82269480
20Decreased central vision (HP:0007663)2.80810479
21Increased density of long bones (HP:0006392)2.67974630
22Abnormality of lateral ventricle (HP:0030047)2.60991827
23Tinnitus (HP:0000360)2.38937625
24Abnormality of iron homeostasis (HP:0011031)2.34066199
25Hepatosplenomegaly (HP:0001433)2.32348225
26Increased IgM level (HP:0003496)2.31461179
27Joint swelling (HP:0001386)2.31264448
28Elevated erythrocyte sedimentation rate (HP:0003565)2.22475247
29Abnormality of transition element cation homeostasis (HP:0011030)2.22407563
30Hyperthyroidism (HP:0000836)2.19848205
31Joint hemorrhage (HP:0005261)2.17484631
32Obstructive lung disease (HP:0006536)2.17306954
33Chronic obstructive pulmonary disease (HP:0006510)2.17306954
34Encephalitis (HP:0002383)2.15265754
35Spontaneous abortion (HP:0005268)2.14482036
36Generalized aminoaciduria (HP:0002909)2.11833407
37Abnormal auditory evoked potentials (HP:0006958)2.11516339
38Abnormality of macrophages (HP:0004311)2.09262680
39Arterial thrombosis (HP:0004420)2.07507518
40Thyroid-stimulating hormone excess (HP:0002925)2.04654999
41Episodic fever (HP:0001954)2.00148642
42Prolonged bleeding time (HP:0003010)11.6931790
43Increased mean platelet volume (HP:0011877)10.3977582
44Menorrhagia (HP:0000132)10.2791398
45Petechiae (HP:0000967)10.1314770
463-Methylglutaconic aciduria (HP:0003535)1.99224097
47Dynein arm defect of respiratory motile cilia (HP:0012255)1.93896926
48Absent/shortened dynein arms (HP:0200106)1.93896926
49Autoimmune hemolytic anemia (HP:0001890)1.93145899
50Nausea (HP:0002018)1.92792478
51Abnormal ciliary motility (HP:0012262)1.91261614
52Abnormality of the prostate (HP:0008775)1.88748226
53Chronic otitis media (HP:0000389)1.85293343
54Xanthomatosis (HP:0000991)1.83585705
55Increased serum ferritin (HP:0003281)1.83560013
56Upper limb muscle weakness (HP:0003484)1.80300349
57Vertigo (HP:0002321)1.80076515
58Abnormal respiratory motile cilium morphology (HP:0005938)1.77058904
59Abnormal respiratory epithelium morphology (HP:0012253)1.77058904
60Chest pain (HP:0100749)1.75298584
61Male infertility (HP:0003251)1.73719982
62Ventricular fibrillation (HP:0001663)1.70764599
63Tongue fasciculations (HP:0001308)1.66567652
64Panhypogammaglobulinemia (HP:0003139)1.65176180
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.63218568
66Abnormality of alanine metabolism (HP:0010916)1.63218568
67Hyperalaninemia (HP:0003348)1.63218568
68Thrombocytosis (HP:0001894)1.61987536
69Polyphagia (HP:0002591)1.60219804
70Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.59419464
71Leukocytosis (HP:0001974)1.56185677
72Hypophosphatemic rickets (HP:0004912)1.55677553
73Muscle fibrillation (HP:0010546)1.55288081
74Dysautonomia (HP:0002459)1.54760054
75Renal Fanconi syndrome (HP:0001994)1.54434044
76Basal ganglia calcification (HP:0002135)1.52766708
77Papillary thyroid carcinoma (HP:0002895)1.52590709
78Diplopia (HP:0000651)1.52506596
79Abnormality of binocular vision (HP:0011514)1.52506596
80Central scotoma (HP:0000603)1.51535907
81Exertional dyspnea (HP:0002875)1.51303639
82Polycythemia (HP:0001901)1.50176811
83Abolished electroretinogram (ERG) (HP:0000550)1.44904429
84Amaurosis fugax (HP:0100576)1.44157764
85Visual hallucinations (HP:0002367)1.40452677
86Thrombophlebitis (HP:0004418)1.39868211
87Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.38612364
88Arthropathy (HP:0003040)1.38279268
89Eczematoid dermatitis (HP:0000976)1.36090132
90Renal cortical cysts (HP:0000803)1.35743796
91Granulocytopenia (HP:0001913)1.35197790
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.34175000
93Hypomagnesemia (HP:0002917)1.33680096
94Recurrent abscess formation (HP:0002722)1.33046577
95Inflammation of the large intestine (HP:0002037)1.32661285
96Biliary tract neoplasm (HP:0100574)1.32621585
97Thyroid carcinoma (HP:0002890)1.31712713
98Clumsiness (HP:0002312)1.31499071
99Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.31283001
100Increased neuronal autofluorescent lipopigment (HP:0002074)1.29420461

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.94176738
2MST44.41279527
3BMX3.62795590
4TEC3.44061867
5TAOK33.43474170
6MYLK3.09015231
7BTK2.95367625
8EIF2AK12.59838710
9SYK2.49950228
10PTK2B2.43166195
11PIK3CG2.15195291
12CSF1R2.06163468
13ADRBK22.04915347
14GRK51.92257030
15GRK61.86384089
16ZAP701.83413482
17BMPR21.66928175
18FES1.61978771
19TXK1.57052563
20NUAK11.53520735
21HCK1.52490259
22ILK1.52341046
23STK31.48705079
24TNK21.41000136
25MAPKAPK31.36406501
26IKBKB1.35994218
27ACVR1B1.34168224
28FGR1.30797316
29ITK1.23058534
30LYN1.22269993
31MAP2K31.19544591
32FRK1.14987253
33IRAK11.13202417
34MATK1.06432918
35DAPK21.05852274
36TLK11.05339921
37MAP4K21.04045924
38PNCK1.03955321
39BMPR1B1.03199314
40PLK21.01438555
41ADRBK11.01277346
42BLK1.00740895
43TNIK0.96980388
44PIM20.94967748
45PAK10.93387026
46DAPK30.90292766
47MAP3K50.86992750
48EPHA30.85975156
49SIK30.79603318
50MAP4K10.79403473
51MARK30.78987883
52PDK10.76729945
53TRIM280.73196547
54PKN10.72161862
55LMTK20.71622354
56MAPK130.71285172
57ZAK0.71255182
58FER0.69391458
59GRK10.68230216
60JAK30.66445680
61LCK0.64865081
62ERBB20.64544320
63CSK0.61679434
64CAMKK20.60850261
65PDPK10.57876575
66PRKD10.55493846
67PRKACG0.54910520
68PRKCQ0.54478544
69MAP2K10.54025864
70STK240.51984864
71MAPK120.50299690
72TESK20.49765626
73DAPK10.49487774
74MAP3K110.48059866
75DYRK20.47359439
76TAOK20.45554905
77JAK20.43600511
78PRKG10.43463612
79PAK30.41804018
80BCKDK0.41773966
81RET0.41659129
82VRK10.40575275
83STK40.40521370
84PRKCD0.39697683
85IRAK40.37776147
86MINK10.37336077
87FYN0.36984295
88PRKCA0.36349305
89PIM10.34974986
90PRKCB0.32115508
91TAOK10.31173493
92KIT0.31012562
93CAMK10.30611381
94IGF1R0.29108080
95JAK10.26117379
96PRKCE0.25954893
97ABL10.24163670
98PRKACA0.24007044
99DYRK1A0.23202549
100YES10.22760117

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.67270605
2SNARE interactions in vesicular transport_Homo sapiens_hsa041303.15267009
3Hematopoietic cell lineage_Homo sapiens_hsa046402.89357167
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.78018058
5Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.72561061
6Nitrogen metabolism_Homo sapiens_hsa009102.60324200
7Arachidonic acid metabolism_Homo sapiens_hsa005902.45471212
8ECM-receptor interaction_Homo sapiens_hsa045121.99124155
9Serotonergic synapse_Homo sapiens_hsa047261.81277366
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75713262
11Chemokine signaling pathway_Homo sapiens_hsa040621.75536542
12Systemic lupus erythematosus_Homo sapiens_hsa053221.74428289
13Vascular smooth muscle contraction_Homo sapiens_hsa042701.61600660
14Linoleic acid metabolism_Homo sapiens_hsa005911.48825130
15Gap junction_Homo sapiens_hsa045401.48561757
16Primary immunodeficiency_Homo sapiens_hsa053401.44666044
17Collecting duct acid secretion_Homo sapiens_hsa049661.43622887
18Alcoholism_Homo sapiens_hsa050341.42293834
19Asthma_Homo sapiens_hsa053101.41470693
20Olfactory transduction_Homo sapiens_hsa047401.35784877
21Allograft rejection_Homo sapiens_hsa053301.27574679
22Graft-versus-host disease_Homo sapiens_hsa053321.26047989
23B cell receptor signaling pathway_Homo sapiens_hsa046621.25676777
24Glycerolipid metabolism_Homo sapiens_hsa005611.24615294
25Fatty acid elongation_Homo sapiens_hsa000621.19546055
26Pancreatic secretion_Homo sapiens_hsa049721.15117444
27Long-term depression_Homo sapiens_hsa047301.12180589
28Staphylococcus aureus infection_Homo sapiens_hsa051501.11341448
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10040647
30Autoimmune thyroid disease_Homo sapiens_hsa053201.09538574
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.06685773
32Phototransduction_Homo sapiens_hsa047441.05432023
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04810510
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01796000
35Circadian entrainment_Homo sapiens_hsa047131.00410723
36Malaria_Homo sapiens_hsa051440.99814028
37Endocytosis_Homo sapiens_hsa041440.99586973
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99016093
39Shigellosis_Homo sapiens_hsa051310.98179706
40T cell receptor signaling pathway_Homo sapiens_hsa046600.97953605
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97297765
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97069967
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96178946
44Morphine addiction_Homo sapiens_hsa050320.95232559
45Sulfur metabolism_Homo sapiens_hsa009200.92611018
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92292959
47Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91043864
48Phagosome_Homo sapiens_hsa041450.84571823
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83752109
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81653872
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80202942
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78996338
53Osteoclast differentiation_Homo sapiens_hsa043800.78978805
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.78904363
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78643650
56Glutathione metabolism_Homo sapiens_hsa004800.77243296
57Type I diabetes mellitus_Homo sapiens_hsa049400.76171490
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.75868089
59Calcium signaling pathway_Homo sapiens_hsa040200.73374036
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72049924
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.71260395
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.68545391
63Leishmaniasis_Homo sapiens_hsa051400.66517668
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62742332
65Rap1 signaling pathway_Homo sapiens_hsa040150.62161589
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62125147
67Viral carcinogenesis_Homo sapiens_hsa052030.60613641
68Rheumatoid arthritis_Homo sapiens_hsa053230.59786424
69Fat digestion and absorption_Homo sapiens_hsa049750.59432463
70Renin secretion_Homo sapiens_hsa049240.59220288
71Regulation of autophagy_Homo sapiens_hsa041400.59173263
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57365874
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.56194327
74Chemical carcinogenesis_Homo sapiens_hsa052040.55134620
75Choline metabolism in cancer_Homo sapiens_hsa052310.55126958
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54835497
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52904199
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51210402
79GABAergic synapse_Homo sapiens_hsa047270.50042020
80Renin-angiotensin system_Homo sapiens_hsa046140.49670535
81Starch and sucrose metabolism_Homo sapiens_hsa005000.49338779
82Legionellosis_Homo sapiens_hsa051340.48690440
83Ras signaling pathway_Homo sapiens_hsa040140.47815227
84ABC transporters_Homo sapiens_hsa020100.45449029
85Salivary secretion_Homo sapiens_hsa049700.44970633
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44659445
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44437856
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42655693
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.41650475
90Tuberculosis_Homo sapiens_hsa051520.40553687
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40511973
92Cholinergic synapse_Homo sapiens_hsa047250.38734225
93Mismatch repair_Homo sapiens_hsa034300.38684664
94Focal adhesion_Homo sapiens_hsa045100.38249861
95Oxytocin signaling pathway_Homo sapiens_hsa049210.38216605
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36629345
97beta-Alanine metabolism_Homo sapiens_hsa004100.36286981
98Gastric acid secretion_Homo sapiens_hsa049710.34982323
99Viral myocarditis_Homo sapiens_hsa054160.34235863
100Dilated cardiomyopathy_Homo sapiens_hsa054140.33477065

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