ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of somitogenesis (GO:0014807)	8.82276785
2	viral mRNA export from host cell nucleus (GO:0046784)	8.61870711
3	regulation of DNA damage checkpoint (GO:2000001)	7.54214633
4	prenylation (GO:0097354)	7.49933527
5	protein prenylation (GO:0018342)	7.49933527
6	DNA replication-dependent nucleosome assembly (GO:0006335)	7.42184504
7	DNA replication-dependent nucleosome organization (GO:0034723)	7.42184504
8	mesonephros development (GO:0001823)	6.24326343
9	sulfation (GO:0051923)	5.65635313
10	viral transcription (GO:0019083)	5.24294132
11	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.97760384
12	positive regulation of RNA splicing (GO:0033120)	4.82167437
13	translational termination (GO:0006415)	4.78974638
14	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	4.69475453
15	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	4.63531799
16	membrane protein ectodomain proteolysis (GO:0006509)	4.63299797
17	otic vesicle formation (GO:0030916)	4.46127691
18	lymphangiogenesis (GO:0001946)	4.23211812
19	regulation of histone H3-K27 methylation (GO:0061085)	4.16831623
20	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	4.14670863
21	peristalsis (GO:0030432)	4.11758886
22	eyelid development in camera-type eye (GO:0061029)	4.05333185
23	replicative senescence (GO:0090399)	3.96960243
24	post-anal tail morphogenesis (GO:0036342)	3.95784115
25	regulation of apoptotic process involved in morphogenesis (GO:1902337)	3.94270656
26	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	3.91657218
27	leukotriene biosynthetic process (GO:0019370)	3.89947218
28	thyroid gland development (GO:0030878)	3.85430906
29	innate immune response in mucosa (GO:0002227)	3.84313067
30	definitive hemopoiesis (GO:0060216)	3.84236060
31	lung morphogenesis (GO:0060425)	3.81966669
32	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	3.76785497
33	translational elongation (GO:0006414)	3.63826983
34	DNA integration (GO:0015074)	3.58365157
35	venous blood vessel morphogenesis (GO:0048845)	3.54092537
36	cellular protein complex disassembly (GO:0043624)	3.50197917
37	embryonic hindlimb morphogenesis (GO:0035116)	3.49185502
38	pharyngeal system development (GO:0060037)	3.42405722
39	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.36782122
40	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.36560929
41	regulation of megakaryocyte differentiation (GO:0045652)	3.32738562
42	membrane protein intracellular domain proteolysis (GO:0031293)	3.30737304
43	histone lysine demethylation (GO:0070076)	3.28792634
44	viral life cycle (GO:0019058)	3.28197490
45	translational initiation (GO:0006413)	3.25867299
46	cotranslational protein targeting to membrane (GO:0006613)	3.23434321
47	embryonic forelimb morphogenesis (GO:0035115)	3.22454752
48	mucosal immune response (GO:0002385)	3.21516228
49	protein targeting to ER (GO:0045047)	3.20229300
50	histone demethylation (GO:0016577)	3.20063887
51	trophoblast giant cell differentiation (GO:0060707)	3.19120506
52	hematopoietic stem cell proliferation (GO:0071425)	3.17607695
53	embryonic skeletal joint morphogenesis (GO:0060272)	3.12254377
54	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	3.06277456
55	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.06228490
56	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.04347607
57	oogenesis (GO:0048477)	3.03186638
58	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	3.02624503
59	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	3.01162863
60	regulation of skeletal muscle contraction (GO:0014819)	3.00233840
61	negative regulation of cardiac muscle tissue development (GO:0055026)	2.99858346
62	membrane protein proteolysis (GO:0033619)	2.97200695
63	positive regulation of DNA-templated transcription, elongation (GO:0032786)	2.94450861
64	dermatan sulfate biosynthetic process (GO:0030208)	2.93973007
65	protein dealkylation (GO:0008214)	2.92846158
66	protein demethylation (GO:0006482)	2.92846158
67	forelimb morphogenesis (GO:0035136)	2.91876671
68	organ or tissue specific immune response (GO:0002251)	2.91770269
69	protein localization to endoplasmic reticulum (GO:0070972)	2.90939148
70	protein complex disassembly (GO:0043241)	2.90578005
71	morphogenesis of embryonic epithelium (GO:0016331)	2.88119406
72	protein K11-linked deubiquitination (GO:0035871)	2.87379296
73	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	2.85110891
74	hindlimb morphogenesis (GO:0035137)	2.84976356
75	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.84667198
76	negative regulation of T-helper cell differentiation (GO:0045623)	2.84667198
77	cell proliferation in forebrain (GO:0021846)	2.83174416
78	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.82618154
79	antibacterial humoral response (GO:0019731)	2.80502754
80	forebrain neuron development (GO:0021884)	2.76903591
81	cAMP biosynthetic process (GO:0006171)	2.76198490
82	embryonic skeletal system morphogenesis (GO:0048704)	2.76012387
83	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.75949817
84	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.75949817
85	NADH dehydrogenase complex assembly (GO:0010257)	2.75949817
86	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.71766651
87	histone H3-K36 demethylation (GO:0070544)	2.71497870
88	dermatan sulfate metabolic process (GO:0030205)	2.69076875
89	cardiac muscle hypertrophy in response to stress (GO:0014898)	2.66172769
90	muscle hypertrophy in response to stress (GO:0003299)	2.66172769
91	cardiac muscle adaptation (GO:0014887)	2.66172769
92	macromolecular complex disassembly (GO:0032984)	2.65592032
93	positive regulation of odontogenesis (GO:0042482)	2.65288564
94	branching involved in salivary gland morphogenesis (GO:0060445)	2.65237286
95	dopamine transport (GO:0015872)	2.65089395
96	outer ear morphogenesis (GO:0042473)	2.63401222
97	aorta morphogenesis (GO:0035909)	2.62836677
98	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.62421038
99	nucleosome assembly (GO:0006334)	2.61717707
100	grooming behavior (GO:0007625)	2.61666626

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	6.47009221
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	6.04228516
3	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.68596896
4	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.81663641
5	VDR_21846776_ChIP-Seq_THP-1_Human	2.55377199
6	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.33376664
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.30644364
8	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	2.13483015
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	16.9508660
10	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.90556986
11	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.90162164
12	GATA1_22025678_ChIP-Seq_K562_Human	1.90088053
13	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.69348982
14	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.67982779
15	VDR_24763502_ChIP-Seq_THP-1_Human	1.59403590
16	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.48790001
17	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.48790001
18	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.48790001
19	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.37724999
20	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.37594255
21	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.35091154
22	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.34794337
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.28782782
24	AR_21572438_ChIP-Seq_LNCaP_Human	1.28113437
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.26414991
26	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.24848053
27	XRN2_22483619_ChIP-Seq_HELA_Human	1.22316906
28	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.19867847
29	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.13462685
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12404208
31	SCL_19346495_ChIP-Seq_HPC-7_Human	1.12182263
32	GATA1_19941826_ChIP-Seq_K562_Human	1.11718038
33	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.11329188
34	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.11123637
35	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.10561867
36	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.08536051
37	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.07252746
38	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.06961708
39	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.06872712
40	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.06687792
41	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.06083705
42	TTF2_22483619_ChIP-Seq_HELA_Human	1.04304228
43	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.03532508
44	BRD4_27068464_Chip-Seq_AML-cells_Mouse	0.99346202
45	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99215455
46	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.98099149
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.97485911
48	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.97394759
49	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.96741061
50	TCF7_22412390_ChIP-Seq_EML_Mouse	0.95113809
51	UTX_26944678_Chip-Seq_JUKART_Human	0.87832220
52	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.86620323
53	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.86342882
54	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.86104603
55	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.84814299
56	MAF_26560356_Chip-Seq_TH1_Human	0.84526076
57	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.83900972
58	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.83900972
59	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.83539641
60	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.82553045
61	KDM2B_26808549_Chip-Seq_DND41_Human	0.80776495
62	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.80672083
63	ATF3_27146783_Chip-Seq_COLON_Human	0.80037269
64	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.79479877
65	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.78923717
66	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.78686185
67	GATA2_19941826_ChIP-Seq_K562_Human	0.77652429
68	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.77082479
69	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.76879016
70	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	0.73137724
71	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.72991718
72	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.71688580
73	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.70244487
74	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.69374659
75	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.68416455
76	ETS1_22383799_ChIP-Seq_G1ME_Mouse	0.67877468
77	DCP1A_22483619_ChIP-Seq_HELA_Human	0.67856399
78	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.67207323
79	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.64659870
80	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.64571295
81	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.64472635
82	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.63179778
83	RACK7_27058665_Chip-Seq_MCF-7_Human	0.63008553
84	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.62942950
85	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.62869187
86	AHR_22903824_ChIP-Seq_MCF-7_Human	0.62155815
87	SA1_22415368_ChIP-Seq_MEFs_Mouse	0.61535611
88	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.61311252
89	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.59426302
90	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.58573823
91	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.58502281
92	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.57951306
93	CREB1_26743006_Chip-Seq_LNCaP_Human	0.57394212
94	* VDR_23849224_ChIP-Seq_CD4+_Human	0.57310603
95	TP53_16413492_ChIP-PET_HCT116_Human	0.56921686
96	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.56011062
97	MYB_26560356_Chip-Seq_TH1_Human	0.55034475
98	CIITA_25753668_ChIP-Seq_RAJI_Human	0.53591853
99	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.52986505
100	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.52880369

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	5.08874915
2	MP0002138_abnormal_hepatobiliary_system	4.41155980
3	MP0005083_abnormal_biliary_tract	4.11543025
4	MP0002163_abnormal_gland_morphology	3.93236066
5	MP0002160_abnormal_reproductive_system	3.61986332
6	MP0000678_abnormal_parathyroid_gland	3.22359530
7	MP0003693_abnormal_embryo_hatching	3.14883708
8	MP0005171_absent_coat_pigmentation	3.06824789
9	MP0005409_darkened_coat_color	2.45257166
10	MP0005503_abnormal_tendon_morphology	2.45210934
11	MP0000750_abnormal_muscle_regeneration	2.42681563
12	MP0002089_abnormal_postnatal_growth/wei	2.22638046
13	MP0005389_reproductive_system_phenotype	2.18893848
14	MP0005379_endocrine/exocrine_gland_phen	2.04031467
15	MP0000569_abnormal_digit_pigmentation	2.02236025
16	MP0002254_reproductive_system_inflammat	1.99823449
17	MP0000613_abnormal_salivary_gland	1.99012175
18	MP0009379_abnormal_foot_pigmentation	1.96082941
19	MP0005423_abnormal_somatic_nervous	1.83588465
20	MP0002928_abnormal_bile_duct	1.79925875
21	MP0010368_abnormal_lymphatic_system	1.79767812
22	MP0003252_abnormal_bile_duct	1.78592152
23	MP0000371_diluted_coat_color	1.75595611
24	MP0005076_abnormal_cell_differentiation	1.68937123
25	MP0003656_abnormal_erythrocyte_physiolo	1.67910375
26	MP0000733_abnormal_muscle_development	1.60665375
27	MP0009250_abnormal_appendicular_skeleto	1.56597418
28	MP0000049_abnormal_middle_ear	1.55939246
29	MP0002877_abnormal_melanocyte_morpholog	1.54355386
30	MP0002108_abnormal_muscle_morphology	1.54225959
31	MP0002127_abnormal_cardiovascular_syste	1.53051828
32	MP0000372_irregular_coat_pigmentation	1.43643407
33	MP0005174_abnormal_tail_pigmentation	1.42408079
34	MP0003942_abnormal_urinary_system	1.40195863
35	MP0004272_abnormal_basement_membrane	1.39493408
36	MP0003828_pulmonary_edema	1.38676218
37	MP0004134_abnormal_chest_morphology	1.35395604
38	MP0005275_abnormal_skin_tensile	1.35124433
39	MP0002009_preneoplasia	1.33054504
40	MP0002822_catalepsy	1.30150521
41	MP0001270_distended_abdomen	1.29102222
42	MP0003959_abnormal_lean_body	1.27890239
43	MP0009384_cardiac_valve_regurgitation	1.27373212
44	MP0003279_aneurysm	1.27102109
45	MP0005220_abnormal_exocrine_pancreas	1.23789890
46	MP0000163_abnormal_cartilage_morphology	1.23688838
47	MP0001986_abnormal_taste_sensitivity	1.22289141
48	MP0004264_abnormal_extraembryonic_tissu	1.19472958
49	MP0001348_abnormal_lacrimal_gland	1.17169141
50	MP0008995_early_reproductive_senescence	1.10814605
51	MP0002971_abnormal_brown_adipose	1.10174475
52	MP0001661_extended_life_span	1.09875954
53	MP0008438_abnormal_cutaneous_collagen	1.06035093
54	MP0001879_abnormal_lymphatic_vessel	1.05257296
55	MP0002249_abnormal_larynx_morphology	1.04065631
56	MP0002932_abnormal_joint_morphology	1.03956345
57	MP0002095_abnormal_skin_pigmentation	1.03810191
58	MP0009780_abnormal_chondrocyte_physiolo	1.01627798
59	MP0004957_abnormal_blastocyst_morpholog	1.01092276
60	MP0004381_abnormal_hair_follicle	1.00644295
61	MP0004808_abnormal_hematopoietic_stem	0.99039103
62	MP0009840_abnormal_foam_cell	0.98565832
63	MP0003111_abnormal_nucleus_morphology	0.97907299
64	MP0000681_abnormal_thyroid_gland	0.97841561
65	MP0009278_abnormal_bone_marrow	0.92805639
66	MP0000762_abnormal_tongue_morphology	0.92209668
67	MP0002075_abnormal_coat/hair_pigmentati	0.89701814
68	MP0005508_abnormal_skeleton_morphology	0.84778263
69	MP0000534_abnormal_ureter_morphology	0.84271142
70	MP0002638_abnormal_pupillary_reflex	0.82859144
71	MP0001542_abnormal_bone_strength	0.82215301
72	MP0003221_abnormal_cardiomyocyte_apopto	0.81647748
73	MP0006138_congestive_heart_failure	0.81324307
74	MP0000751_myopathy	0.78954498
75	MP0003077_abnormal_cell_cycle	0.78686208
76	MP0001119_abnormal_female_reproductive	0.77679814
77	MP0002139_abnormal_hepatobiliary_system	0.76264614
78	MP0000759_abnormal_skeletal_muscle	0.75677065
79	MP0001502_abnormal_circadian_rhythm	0.75648745
80	MP0001340_abnormal_eyelid_morphology	0.74005394
81	MP0002060_abnormal_skin_morphology	0.73826842
82	MP0005385_cardiovascular_system_phenoty	0.73727381
83	MP0001544_abnormal_cardiovascular_syste	0.73727381
84	MP0002114_abnormal_axial_skeleton	0.70629632
85	MP0005084_abnormal_gallbladder_morpholo	0.69412768
86	MP0000428_abnormal_craniofacial_morphol	0.67713169
87	MP0003935_abnormal_craniofacial_develop	0.64551325
88	MP0000749_muscle_degeneration	0.64372440
89	MP0002116_abnormal_craniofacial_bone	0.63347717
90	MP0004087_abnormal_muscle_fiber	0.62290258
91	MP0001784_abnormal_fluid_regulation	0.61841559
92	MP0000767_abnormal_smooth_muscle	0.60753971
93	MP0001145_abnormal_male_reproductive	0.60547596
94	MP0002111_abnormal_tail_morphology	0.60206268
95	MP0005334_abnormal_fat_pad	0.58261597
96	MP0000631_abnormal_neuroendocrine_gland	0.58127474
97	MP0000358_abnormal_cell_content/	0.57787806
98	MP0002086_abnormal_extraembryonic_tissu	0.57636687
99	MP0000350_abnormal_cell_proliferation	0.56062471
100	MP0000467_abnormal_esophagus_morphology	0.55456253

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Anomalous pulmonary venous return (HP:0010772)	7.60063527
2	Slow saccadic eye movements (HP:0000514)	6.84984723
3	Abnormality of the pulmonary veins (HP:0011718)	6.79546801
4	Tongue fasciculations (HP:0001308)	6.56135345
5	Muscle fibrillation (HP:0010546)	5.78797800
6	Oral leukoplakia (HP:0002745)	5.61211658
7	J-shaped sella turcica (HP:0002680)	5.17351975
8	Diastasis recti (HP:0001540)	4.66521357
9	Vertebral arch anomaly (HP:0008438)	4.63411925
10	Aortic regurgitation (HP:0001659)	4.47433500
11	Abnormality of the odontoid process (HP:0003310)	4.29064461
12	Deformed sella turcica (HP:0002681)	4.18149758
13	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	4.02840909
14	Carpal bone hypoplasia (HP:0001498)	3.88822715
15	Thoracolumbar scoliosis (HP:0002944)	3.85525364
16	Impaired smooth pursuit (HP:0007772)	3.82945986
17	Broad ribs (HP:0000885)	3.73351618
18	Premature graying of hair (HP:0002216)	3.62239649
19	Abnormality of the lumbar spine (HP:0100712)	3.58597675
20	Abnormal number of erythroid precursors (HP:0012131)	3.35634534
21	Rectal prolapse (HP:0002035)	3.26487771
22	Abnormality of ocular smooth pursuit (HP:0000617)	3.22993801
23	Progressive muscle weakness (HP:0003323)	3.15296247
24	Abnormality of the sella turcica (HP:0002679)	2.97406158
25	Flared iliac wings (HP:0002869)	2.94637974
26	Thoracic kyphosis (HP:0002942)	2.84395308
27	Coronal craniosynostosis (HP:0004440)	2.84129648
28	Abnormality of cells of the erythroid lineage (HP:0012130)	2.83033135
29	Beaking of vertebral bodies (HP:0004568)	2.80775342
30	Abnormality of liposaccharide metabolism (HP:0010968)	2.80737079
31	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.80737079
32	Abnormality of glycolipid metabolism (HP:0010969)	2.80737079
33	Lip pit (HP:0100267)	2.77440259
34	Rough bone trabeculation (HP:0100670)	2.76793158
35	Prominent occiput (HP:0000269)	2.74779443
36	Abnormality of the intervertebral disk (HP:0005108)	2.70220866
37	Flat acetabular roof (HP:0003180)	2.69175113
38	Genetic anticipation (HP:0003743)	2.68192190
39	Periauricular skin pits (HP:0100277)	2.62796342
40	Preauricular pit (HP:0004467)	2.62796342
41	Lymphangioma (HP:0100764)	2.57871284
42	Sparse lateral eyebrow (HP:0005338)	2.54613827
43	Abnormality of the thoracic spine (HP:0100711)	2.47793141
44	Vertebral fusion (HP:0002948)	2.46701545
45	Abnormality of saccadic eye movements (HP:0000570)	2.46038836
46	Increased serum ferritin (HP:0003281)	2.45117656
47	Myelomeningocele (HP:0002475)	2.42138488
48	Urethral obstruction (HP:0000796)	2.39350176
49	Gonadotropin excess (HP:0000837)	2.35514762
50	Squamous cell carcinoma (HP:0002860)	2.34325843
51	Skin pits (HP:0100276)	2.29781091
52	Limb ataxia (HP:0002070)	2.29656894
53	Mucopolysacchariduria (HP:0008155)	2.26923079
54	Urinary glycosaminoglycan excretion (HP:0003541)	2.26923079
55	Severe visual impairment (HP:0001141)	2.23266638
56	Dysostosis multiplex (HP:0000943)	2.20674876
57	Broad alveolar ridges (HP:0000187)	2.20524345
58	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.12947188
59	Morphological abnormality of the middle ear (HP:0008609)	2.09913965
60	Abnormality of the nasal septum (HP:0000419)	2.09867658
61	Death in childhood (HP:0003819)	2.09774028
62	Abnormal trabecular bone morphology (HP:0100671)	2.08215614
63	Decreased central vision (HP:0007663)	2.04851348
64	Wide intermamillary distance (HP:0006610)	2.02921834
65	Abnormality of the 2nd finger (HP:0004100)	2.02281474
66	Thickened calvaria (HP:0002684)	1.96841486
67	Hypoplastic pelvis (HP:0008839)	1.95757643
68	Abnormality of the preputium (HP:0100587)	1.93357785
69	Ectopic kidney (HP:0000086)	1.92508864
70	Hemiplegia (HP:0002301)	1.89293997
71	Ovoid vertebral bodies (HP:0003300)	1.87866026
72	Abnormality of the frontal sinuses (HP:0002687)	1.85084905
73	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.84217872
74	Abnormality of polysaccharide metabolism (HP:0011012)	1.84217872
75	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.84217872
76	Bone marrow hypocellularity (HP:0005528)	1.83940590
77	Pathologic fracture (HP:0002756)	1.83097852
78	Abnormality of iron homeostasis (HP:0011031)	1.81643538
79	Abnormality of the wing of the ilium (HP:0011867)	1.81446150
80	Spina bifida occulta (HP:0003298)	1.81242226
81	Abnormal pancreas size (HP:0012094)	1.79993413
82	Hemivertebrae (HP:0002937)	1.79731642
83	Fibular aplasia (HP:0002990)	1.75579578
84	Short femoral neck (HP:0100864)	1.75513845
85	Small hand (HP:0200055)	1.75050071
86	Oligodontia (HP:0000677)	1.75044168
87	Hypochromic anemia (HP:0001931)	1.74150435
88	Recurrent bronchitis (HP:0002837)	1.72199138
89	Congenital, generalized hypertrichosis (HP:0004540)	1.71563153
90	Abnormality of the columella (HP:0009929)	1.70359697
91	Hypoplasia of the odontoid process (HP:0003311)	1.70254887
92	Meningocele (HP:0002435)	1.69460856
93	Narrow palate (HP:0000189)	1.68354123
94	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.63232030
95	Pendular nystagmus (HP:0012043)	1.63033174
96	Dysautonomia (HP:0002459)	1.62147761
97	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.61748936
98	White forelock (HP:0002211)	1.61675171
99	Syringomyelia (HP:0003396)	1.61674873
100	Spinal cord lesions (HP:0100561)	1.61674873

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	7.99216461
2	BLK	7.22198165
3	ZAK	7.10286910
4	RIPK1	2.52246637
5	VRK1	2.26667252
6	STK4	2.02470642
7	TAOK3	1.79258602
8	MAP3K3	1.66833670
9	MAP3K2	1.63472394
10	MAP2K3	1.56028885
11	GRK6	1.48820339
12	MAP3K9	1.45877988
13	CAMK4	1.44052566
14	MAP3K6	1.41005880
15	PIM1	1.31087540
16	GRK7	1.30333648
17	RPS6KA5	1.29915345
18	MAPK7	1.28802384
19	PRPF4B	1.26908197
20	HIPK2	1.19041942
21	DAPK3	1.05626329
22	SIK1	1.03288972
23	INSRR	1.00916556
24	PDK2	0.98335069
25	MAP3K7	0.98313136
26	CAMKK2	0.91883728
27	TRIB3	0.91789242
28	TAF1	0.89479244
29	AURKA	0.86773237
30	GRK5	0.86726125
31	SGK2	0.86145348
32	TGFBR2	0.84897259
33	RPS6KA6	0.82292671
34	SYK	0.81866781
35	RPS6KC1	0.81289255
36	RPS6KL1	0.81289255
37	BRSK2	0.78147355
38	SGK3	0.74845801
39	PKN1	0.72843989
40	IKBKB	0.69724127
41	CDK12	0.69042818
42	RIPK4	0.65817895
43	ERN1	0.65697142
44	BRSK1	0.63216507
45	KDR	0.57431868
46	IRAK2	0.57120709
47	MELK	0.57052293
48	ADRBK1	0.55893810
49	GRK1	0.54064317
50	SGK223	0.48885377
51	SGK494	0.48885377
52	AKT2	0.48127523
53	IKBKE	0.47919603
54	NEK6	0.44872498
55	PRKAA1	0.44415830
56	CLK1	0.43786747
57	MAP3K8	0.43511699
58	ABL2	0.43493093
59	MAPK12	0.42525946
60	PKN2	0.42416090
61	STK38	0.42169738
62	AURKB	0.41587959
63	BRD4	0.41469788
64	STK16	0.41434172
65	FGFR1	0.41343734
66	EPHA2	0.40719310
67	CAMK1D	0.38083828
68	MOS	0.37750626
69	NME2	0.37336768
70	PDGFRB	0.37141884
71	TBK1	0.35081867
72	JAK2	0.34704721
73	MATK	0.34202443
74	SCYL2	0.33564677
75	LYN	0.33487659
76	CAMK2B	0.33111322
77	ADRBK2	0.32954379
78	WNK1	0.32445032
79	MTOR	0.32266395
80	STK11	0.30475254
81	MAPK11	0.30342592
82	PTK2B	0.30017014
83	AKT3	0.28763252
84	BMPR2	0.27469191
85	MAP3K1	0.26828431
86	ICK	0.25720634
87	WNK4	0.25669786
88	MAPK15	0.25014283
89	SGK1	0.24661156
90	MARK2	0.24464695
91	DYRK3	0.23867708
92	MAPK1	0.23549160
93	IRAK1	0.23332370
94	RAF1	0.23080599
95	TEC	0.21401566
96	PIM2	0.21217797
97	MAP3K5	0.21023648
98	MAPK8	0.20920793
99	HCK	0.20715255
100	RPS6KB1	0.20566760

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	7.83318827
2	Alcoholism_Homo sapiens_hsa05034	5.43891489
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.25883073
4	Viral carcinogenesis_Homo sapiens_hsa05203	2.89465018
5	Ribosome_Homo sapiens_hsa03010	2.68800795
6	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.64702931
7	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.96558930
8	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.78680572
9	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.60590619
10	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.46913178
11	Melanoma_Homo sapiens_hsa05218	1.39519241
12	mTOR signaling pathway_Homo sapiens_hsa04150	1.34991664
13	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.18215623
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.15719012
15	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.15016995
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.07662876
17	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.06968482
18	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.02797858
19	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.01894473
20	MicroRNAs in cancer_Homo sapiens_hsa05206	0.99537236
21	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.97527114
22	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.95875251
23	Basal cell carcinoma_Homo sapiens_hsa05217	0.93761124
24	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.93612240
25	Acute myeloid leukemia_Homo sapiens_hsa05221	0.92514341
26	Basal transcription factors_Homo sapiens_hsa03022	0.92102677
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.90988777
28	TNF signaling pathway_Homo sapiens_hsa04668	0.90912512
29	Non-small cell lung cancer_Homo sapiens_hsa05223	0.90529657
30	HTLV-I infection_Homo sapiens_hsa05166	0.88990598
31	MAPK signaling pathway_Homo sapiens_hsa04010	0.88468593
32	Gap junction_Homo sapiens_hsa04540	0.84916418
33	Osteoclast differentiation_Homo sapiens_hsa04380	0.83713755
34	Leishmaniasis_Homo sapiens_hsa05140	0.82269389
35	Bladder cancer_Homo sapiens_hsa05219	0.82016243
36	Prolactin signaling pathway_Homo sapiens_hsa04917	0.81688486
37	Influenza A_Homo sapiens_hsa05164	0.81261933
38	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.80400358
39	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.80105896
40	GnRH signaling pathway_Homo sapiens_hsa04912	0.79805109
41	Small cell lung cancer_Homo sapiens_hsa05222	0.79473223
42	Taste transduction_Homo sapiens_hsa04742	0.73819300
43	Circadian rhythm_Homo sapiens_hsa04710	0.70826619
44	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.70248334
45	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.69645099
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.69603487
47	Melanogenesis_Homo sapiens_hsa04916	0.68899853
48	Platelet activation_Homo sapiens_hsa04611	0.67055545
49	ErbB signaling pathway_Homo sapiens_hsa04012	0.66063128
50	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.64661717
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64113028
52	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.63738041
53	Cholinergic synapse_Homo sapiens_hsa04725	0.63044787
54	Glioma_Homo sapiens_hsa05214	0.62397155
55	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.61477928
56	Prostate cancer_Homo sapiens_hsa05215	0.60275372
57	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.59036481
58	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.58286180
59	FoxO signaling pathway_Homo sapiens_hsa04068	0.58263723
60	Morphine addiction_Homo sapiens_hsa05032	0.55572078
61	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.55194332
62	Insulin resistance_Homo sapiens_hsa04931	0.54370776
63	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.53848115
64	Pathways in cancer_Homo sapiens_hsa05200	0.53295363
65	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.52895588
66	Herpes simplex infection_Homo sapiens_hsa05168	0.52771760
67	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.52357756
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51992988
69	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.50962838
70	Estrogen signaling pathway_Homo sapiens_hsa04915	0.50829518
71	Apoptosis_Homo sapiens_hsa04210	0.50672189
72	VEGF signaling pathway_Homo sapiens_hsa04370	0.50182529
73	Calcium signaling pathway_Homo sapiens_hsa04020	0.50121075
74	Spliceosome_Homo sapiens_hsa03040	0.49780856
75	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.47310269
76	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.46667739
77	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.45598237
78	Hepatitis C_Homo sapiens_hsa05160	0.45558959
79	Measles_Homo sapiens_hsa05162	0.45506753
80	Type II diabetes mellitus_Homo sapiens_hsa04930	0.43829788
81	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.42828604
82	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.41869913
83	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.40047028
84	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.39140960
85	Wnt signaling pathway_Homo sapiens_hsa04310	0.37260673
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.37230581
87	Renin secretion_Homo sapiens_hsa04924	0.36943273
88	Renal cell carcinoma_Homo sapiens_hsa05211	0.36832304
89	Olfactory transduction_Homo sapiens_hsa04740	0.35476144
90	RNA transport_Homo sapiens_hsa03013	0.34827219
91	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.34638750
92	Choline metabolism in cancer_Homo sapiens_hsa05231	0.34540495
93	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.34404648
94	Regulation of autophagy_Homo sapiens_hsa04140	0.33868617
95	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.32185615
96	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.31306773
97	Tuberculosis_Homo sapiens_hsa05152	0.31247713
98	p53 signaling pathway_Homo sapiens_hsa04115	0.31013477
99	Salivary secretion_Homo sapiens_hsa04970	0.29630511
100	Toxoplasmosis_Homo sapiens_hsa05145	0.28435907

C6ORF48

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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