C6ORF58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to microtubule (GO:0035372)6.84055392
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.86399471
3attachment of spindle microtubules to kinetochore (GO:0008608)5.66867776
4icosanoid secretion (GO:0032309)5.59732686
5arachidonic acid secretion (GO:0050482)5.59732686
6protein localization to kinetochore (GO:0034501)5.44703618
7sequestering of actin monomers (GO:0042989)4.94573650
8ganglion development (GO:0061548)4.86285821
9ribonucleoprotein complex disassembly (GO:0032988)4.53062942
10icosanoid transport (GO:0071715)4.49878807
11fatty acid derivative transport (GO:1901571)4.49878807
12glycerophospholipid catabolic process (GO:0046475)4.46775256
13organelle disassembly (GO:1903008)4.42507314
14protein polyglutamylation (GO:0018095)4.41173610
15response to histamine (GO:0034776)4.33776302
16sphingosine metabolic process (GO:0006670)3.95843175
17protein localization to microtubule cytoskeleton (GO:0072698)3.87979011
18pyrimidine nucleobase catabolic process (GO:0006208)3.82206828
19DNA double-strand break processing (GO:0000729)3.71601632
20regulation of phospholipase A2 activity (GO:0032429)3.69989824
21protein localization to chromosome, centromeric region (GO:0071459)3.66334759
22chemosensory behavior (GO:0007635)3.58280206
23behavioral response to ethanol (GO:0048149)3.52698805
24diol metabolic process (GO:0034311)3.48134097
25grooming behavior (GO:0007625)3.41677323
26negative regulation of telomere maintenance (GO:0032205)3.40766811
27intracellular protein transmembrane import (GO:0044743)3.39755993
28microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.37957368
29acrosome reaction (GO:0007340)3.30749237
30spermatid nucleus differentiation (GO:0007289)3.29394098
31protein targeting to Golgi (GO:0000042)3.29327080
32dopamine biosynthetic process (GO:0042416)3.27374452
33microtubule depolymerization (GO:0007019)3.22835611
34positive regulation of mitochondrial fission (GO:0090141)3.22246284
35positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.21497615
36seminiferous tubule development (GO:0072520)3.19851826
37sympathetic nervous system development (GO:0048485)3.18208677
38protein-chromophore linkage (GO:0018298)3.15677950
39nucleobase catabolic process (GO:0046113)3.14925608
40auditory behavior (GO:0031223)3.13867189
41substrate-independent telencephalic tangential migration (GO:0021826)3.10402039
42substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.10402039
43keratinization (GO:0031424)3.08536779
44establishment of protein localization to Golgi (GO:0072600)3.07895064
45regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.05313732
46synaptic transmission, dopaminergic (GO:0001963)3.02234293
47axon extension involved in axon guidance (GO:0048846)3.01774853
48neuron projection extension involved in neuron projection guidance (GO:1902284)3.01774853
49sphingoid metabolic process (GO:0046519)3.00962732
50protein localization to cytoskeleton (GO:0044380)3.00769022
51protein K11-linked ubiquitination (GO:0070979)2.94769721
52regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.93117038
53chaperone-mediated protein transport (GO:0072321)2.89021600
54pseudouridine synthesis (GO:0001522)2.88640130
55axonal fasciculation (GO:0007413)2.88408113
56inositol phosphate-mediated signaling (GO:0048016)2.87527728
57lipopolysaccharide biosynthetic process (GO:0009103)2.87327248
58retrograde transport, vesicle recycling within Golgi (GO:0000301)2.86644282
59primary amino compound metabolic process (GO:1901160)2.85663239
60epithelial cilium movement (GO:0003351)2.84371979
61positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.83184456
62mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.83184456
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82507968
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82507968
65cell morphogenesis involved in neuron differentiation (GO:0048667)2.82268448
66response to auditory stimulus (GO:0010996)2.80540699
67regulation of male gonad development (GO:2000018)2.79314038
68forebrain neuron differentiation (GO:0021879)2.78680600
69reflex (GO:0060004)2.78210147
70protein retention in ER lumen (GO:0006621)2.78117819
71natural killer cell mediated immunity (GO:0002228)2.74684073
72natural killer cell mediated cytotoxicity (GO:0042267)2.74684073
73cellular biogenic amine biosynthetic process (GO:0042401)2.71188863
74negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.69880930
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.69121119
76regulation of double-strand break repair via homologous recombination (GO:0010569)2.67345090
77lung secretory cell differentiation (GO:0061140)2.65537112
78cullin deneddylation (GO:0010388)2.63810590
79long-chain fatty acid biosynthetic process (GO:0042759)2.62614902
80sensory perception of smell (GO:0007608)2.62088290
81paraxial mesoderm development (GO:0048339)2.61066917
82cilium or flagellum-dependent cell motility (GO:0001539)2.61010482
83negative chemotaxis (GO:0050919)2.58528218
84hippocampus development (GO:0021766)2.56506691
85startle response (GO:0001964)2.55072001
86pantothenate metabolic process (GO:0015939)2.54723882
87pyrimidine dimer repair (GO:0006290)2.53315137
88facial nerve structural organization (GO:0021612)2.53208353
89mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.52524047
90gamma-aminobutyric acid transport (GO:0015812)2.52496645
91positive regulation of protein depolymerization (GO:1901881)2.50340218
92rRNA catabolic process (GO:0016075)2.50325166
93positive regulation of microtubule polymerization (GO:0031116)2.49474497
94protein localization to synapse (GO:0035418)2.48815965
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.48198082
96negative regulation of oligodendrocyte differentiation (GO:0048715)2.47849392
97protein localization to chromosome (GO:0034502)2.45801510
98serotonin metabolic process (GO:0042428)2.45218259
99cilium movement (GO:0003341)2.44382419
100negative regulation of microtubule polymerization (GO:0031115)2.44264639

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.47208495
2IGF1R_20145208_ChIP-Seq_DFB_Human3.14094936
3ZNF274_21170338_ChIP-Seq_K562_Hela3.00564888
4FUS_26573619_Chip-Seq_HEK293_Human2.97943574
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.93832797
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.92323179
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.90298205
8EZH2_22144423_ChIP-Seq_EOC_Human2.83102257
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.75192656
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.70051991
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54062604
12P300_19829295_ChIP-Seq_ESCs_Human2.49140157
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47845497
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29064490
15TAF15_26573619_Chip-Seq_HEK293_Human2.17921719
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01604634
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95798054
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.95438248
19GBX2_23144817_ChIP-Seq_PC3_Human1.95024959
20SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.92635456
21EWS_26573619_Chip-Seq_HEK293_Human1.89264710
22SMAD3_21741376_ChIP-Seq_EPCs_Human1.86079542
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82911285
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.81814674
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74913412
26CBP_20019798_ChIP-Seq_JUKART_Human1.72905985
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.72905985
28TOP2B_26459242_ChIP-Seq_MCF-7_Human1.71765261
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.63973241
30TP53_18474530_ChIP-ChIP_U2OS_Human1.62211419
31VDR_22108803_ChIP-Seq_LS180_Human1.58270409
32AR_21572438_ChIP-Seq_LNCaP_Human1.54004556
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53973372
34AR_25329375_ChIP-Seq_VCAP_Human1.53443739
35SOX2_16153702_ChIP-ChIP_HESCs_Human1.53060546
36* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51614030
37P53_22127205_ChIP-Seq_FIBROBLAST_Human1.51345780
38RNF2_27304074_Chip-Seq_NSC_Mouse1.51220721
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49865314
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49057518
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.47903866
42SMAD4_21799915_ChIP-Seq_A2780_Human1.47838489
43STAT3_23295773_ChIP-Seq_U87_Human1.45513010
44IRF1_19129219_ChIP-ChIP_H3396_Human1.44743100
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.43507207
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43051111
47* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.42012498
48SMAD4_21741376_ChIP-Seq_EPCs_Human1.41823881
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39840488
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36705768
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35779756
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.35058623
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34347796
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31351458
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30299239
56NANOG_19829295_ChIP-Seq_ESCs_Human1.28858343
57SOX2_19829295_ChIP-Seq_ESCs_Human1.28858343
58KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27457279
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25400460
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24406600
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22758335
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21973673
63FLI1_21867929_ChIP-Seq_TH2_Mouse1.21965267
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.21248912
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.20676361
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19786638
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18834802
68EGR1_19032775_ChIP-ChIP_M12_Human1.18058682
69TCF4_22108803_ChIP-Seq_LS180_Human1.16918041
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.16621905
71ER_23166858_ChIP-Seq_MCF-7_Human1.16503246
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16165956
73TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14924930
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14648931
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14648931
76ERG_20517297_ChIP-Seq_VCAP_Human1.11522461
77RUNX2_22187159_ChIP-Seq_PCA_Human1.11349638
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10043722
79FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09592848
80TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07101417
81* CJUN_26792858_Chip-Seq_BT549_Human1.06535826
82TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05519829
83REST_21632747_ChIP-Seq_MESCs_Mouse1.04794922
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04195548
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.03980007
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03655933
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02548676
88REST_18959480_ChIP-ChIP_MESCs_Mouse1.01477994
89FOXA1_25329375_ChIP-Seq_VCAP_Human0.99825057
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99825057
91TP53_22573176_ChIP-Seq_HFKS_Human0.99666199
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.99613519
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99560535
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98453085
95TCF4_23295773_ChIP-Seq_U87_Human0.97947311
96STAT3_18555785_ChIP-Seq_MESCs_Mouse0.97494383
97CBP_21632823_ChIP-Seq_H3396_Human0.97376837
98SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97303426
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97042638
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96350495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.48640595
2MP0000569_abnormal_digit_pigmentation3.91677996
3MP0002837_dystrophic_cardiac_calcinosis3.81028853
4MP0001529_abnormal_vocalization3.17586987
5MP0002822_catalepsy3.01932464
6MP0006276_abnormal_autonomic_nervous2.51188445
7MP0001188_hyperpigmentation2.48786702
8MP0006072_abnormal_retinal_apoptosis2.41959719
9MP0005499_abnormal_olfactory_system2.41336781
10MP0005394_taste/olfaction_phenotype2.41336781
11MP0009046_muscle_twitch2.39208059
12MP0008789_abnormal_olfactory_epithelium2.29545834
13MP0004742_abnormal_vestibular_system2.09161536
14MP0000778_abnormal_nervous_system2.06527576
15MP0001501_abnormal_sleep_pattern1.99866595
16MP0003136_yellow_coat_color1.96076930
17MP0003879_abnormal_hair_cell1.90615595
18MP0002735_abnormal_chemical_nociception1.86949669
19MP0000049_abnormal_middle_ear1.86214005
20MP0003890_abnormal_embryonic-extraembry1.79960508
21MP0004043_abnormal_pH_regulation1.78734905
22MP0001440_abnormal_grooming_behavior1.68625064
23MP0000013_abnormal_adipose_tissue1.67226456
24MP0002234_abnormal_pharynx_morphology1.60633202
25MP0005253_abnormal_eye_physiology1.58011177
26MP0002733_abnormal_thermal_nociception1.57424719
27MP0008058_abnormal_DNA_repair1.55199203
28MP0005171_absent_coat_pigmentation1.52788611
29MP0001905_abnormal_dopamine_level1.52427543
30MP0003646_muscle_fatigue1.49999786
31MP0002272_abnormal_nervous_system1.47962382
32MP0004142_abnormal_muscle_tone1.45710077
33MP0008569_lethality_at_weaning1.45286457
34MP0003880_abnormal_central_pattern1.38513682
35MP0002233_abnormal_nose_morphology1.37659353
36MP0003045_fibrosis1.37588697
37MP0002572_abnormal_emotion/affect_behav1.36938591
38MP0001486_abnormal_startle_reflex1.35781359
39MP0005670_abnormal_white_adipose1.33878371
40MP0003329_amyloid_beta_deposits1.32815947
41MP0001984_abnormal_olfaction1.32670376
42MP0002067_abnormal_sensory_capabilities1.26658131
43MP0000026_abnormal_inner_ear1.26580674
44MP0002557_abnormal_social/conspecific_i1.26163587
45MP0002938_white_spotting1.25157479
46MP0001485_abnormal_pinna_reflex1.22081997
47MP0004811_abnormal_neuron_physiology1.18778342
48MP0003567_abnormal_fetal_cardiomyocyte1.15775958
49MP0002095_abnormal_skin_pigmentation1.15393198
50MP0002751_abnormal_autonomic_nervous1.13882821
51MP0002064_seizures1.12407099
52MP0000631_abnormal_neuroendocrine_gland1.12352885
53MP0002102_abnormal_ear_morphology1.11103139
54MP0003137_abnormal_impulse_conducting1.09217277
55MP0002876_abnormal_thyroid_physiology1.08399949
56MP0001963_abnormal_hearing_physiology1.07961213
57MP0009745_abnormal_behavioral_response1.06310211
58MP0005275_abnormal_skin_tensile1.05823208
59MP0004859_abnormal_synaptic_plasticity1.04891235
60MP0002184_abnormal_innervation1.03972420
61MP0008872_abnormal_physiological_respon1.03107442
62MP0005085_abnormal_gallbladder_physiolo1.03101754
63MP0002229_neurodegeneration1.02558439
64MP0002909_abnormal_adrenal_gland1.02215652
65MP0002882_abnormal_neuron_morphology1.01502223
66MP0003878_abnormal_ear_physiology1.00302736
67MP0005377_hearing/vestibular/ear_phenot1.00302736
68MP0008961_abnormal_basal_metabolism0.98972593
69MP0005423_abnormal_somatic_nervous0.98849731
70MP0005365_abnormal_bile_salt0.97959986
71MP0003937_abnormal_limbs/digits/tail_de0.97514617
72MP0008995_early_reproductive_senescence0.93128252
73MP0003635_abnormal_synaptic_transmissio0.92134914
74MP0002332_abnormal_exercise_endurance0.90485105
75MP0002638_abnormal_pupillary_reflex0.90278133
76MP0002063_abnormal_learning/memory/cond0.89260098
77MP0001970_abnormal_pain_threshold0.88821895
78MP0002752_abnormal_somatic_nervous0.88173032
79MP0003755_abnormal_palate_morphology0.86073319
80MP0004272_abnormal_basement_membrane0.84704673
81MP0008775_abnormal_heart_ventricle0.84221166
82MP0003693_abnormal_embryo_hatching0.81928652
83MP0002736_abnormal_nociception_after0.81839604
84MP0001293_anophthalmia0.81645300
85MP0003315_abnormal_perineum_morphology0.81065035
86MP0002152_abnormal_brain_morphology0.80081909
87MP0001666_abnormal_nutrient_absorption0.80057732
88MP0005551_abnormal_eye_electrophysiolog0.79881500
89MP0003861_abnormal_nervous_system0.78919982
90MP0004085_abnormal_heartbeat0.77649166
91MP0001270_distended_abdomen0.76408475
92MP0003941_abnormal_skin_development0.73064460
93MP0005645_abnormal_hypothalamus_physiol0.72489328
94MP0004145_abnormal_muscle_electrophysio0.71900450
95MP0003698_abnormal_male_reproductive0.71371215
96MP0003638_abnormal_response/metabolism_0.70827117
97MP0003942_abnormal_urinary_system0.68890145
98MP0002210_abnormal_sex_determination0.67471062
99MP0005187_abnormal_penis_morphology0.67308345
100MP0006036_abnormal_mitochondrial_physio0.65378172

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.74583584
2Limb dystonia (HP:0002451)4.10616635
3True hermaphroditism (HP:0010459)4.04365613
4Abnormal biliary tract physiology (HP:0012439)4.02035282
5Bile duct proliferation (HP:0001408)4.02035282
6Pancreatic cysts (HP:0001737)3.78687640
7Parakeratosis (HP:0001036)3.71337927
8Pancreatic fibrosis (HP:0100732)3.69760058
9Nephronophthisis (HP:0000090)3.40453995
10Abnormality of midbrain morphology (HP:0002418)3.39667970
11Molar tooth sign on MRI (HP:0002419)3.39667970
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.38720426
13Amelogenesis imperfecta (HP:0000705)3.23142202
14Focal motor seizures (HP:0011153)3.19493410
15Pendular nystagmus (HP:0012043)3.18557306
16Acanthocytosis (HP:0001927)3.15040319
17Abnormality of the renal medulla (HP:0100957)3.13019476
18Cortical dysplasia (HP:0002539)3.02864641
19Aplasia/Hypoplasia of the tongue (HP:0010295)2.96181094
20Congenital ichthyosiform erythroderma (HP:0007431)2.91207877
21Bifid tongue (HP:0010297)2.88765073
22Erythroderma (HP:0001019)2.82949875
23Febrile seizures (HP:0002373)2.76580858
24Abnormal number of erythroid precursors (HP:0012131)2.75566234
25Thyroid-stimulating hormone excess (HP:0002925)2.73313449
26Congenital stationary night blindness (HP:0007642)2.72120833
27Aplasia/Hypoplasia of the brainstem (HP:0007362)2.70759010
28Hypoplasia of the brainstem (HP:0002365)2.70759010
29Dialeptic seizures (HP:0011146)2.55711734
30Dyskinesia (HP:0100660)2.52955563
31Abnormality of cells of the erythroid lineage (HP:0012130)2.46005485
32Cutaneous melanoma (HP:0012056)2.45785954
33Cystic liver disease (HP:0006706)2.44037013
34Furrowed tongue (HP:0000221)2.43917505
35Absence seizures (HP:0002121)2.43809581
36Atrophy/Degeneration involving motor neurons (HP:0007373)2.41128308
37Tubulointerstitial nephritis (HP:0001970)2.40031202
383-Methylglutaconic aciduria (HP:0003535)2.32782749
39Hypoplastic ischia (HP:0003175)2.30661421
40Amyotrophic lateral sclerosis (HP:0007354)2.28930177
41Abnormality of the lower motor neuron (HP:0002366)2.28573926
42Optic nerve coloboma (HP:0000588)2.28381125
43Anencephaly (HP:0002323)2.28299503
44Acute necrotizing encephalopathy (HP:0006965)2.26064610
45Abnormality of the renal collecting system (HP:0004742)2.23470925
46Aplastic anemia (HP:0001915)2.20079137
47Meckel diverticulum (HP:0002245)2.19851670
48Severe Myopia (HP:0011003)2.16431419
49Chronic hepatic failure (HP:0100626)2.13894126
50Abnormality of the ileum (HP:0001549)2.13050760
51Esotropia (HP:0000565)2.11723400
52Abnormal mitochondria in muscle tissue (HP:0008316)2.09690031
53Reticulocytopenia (HP:0001896)2.07852176
54Stenosis of the external auditory canal (HP:0000402)2.07166554
55Abnormality of the anterior horn cell (HP:0006802)2.05980984
56Degeneration of anterior horn cells (HP:0002398)2.05980984
57Sclerocornea (HP:0000647)2.04212170
58Duplicated collecting system (HP:0000081)2.04110201
59Gonadotropin excess (HP:0000837)2.01933959
60Clubbing of toes (HP:0100760)2.01544643
61Progressive inability to walk (HP:0002505)2.00307564
62Abnormality of the labia minora (HP:0012880)2.00214882
63Abnormal ciliary motility (HP:0012262)1.95077594
64Amblyopia (HP:0000646)1.93073015
65Chorioretinal coloboma (HP:0000567)1.92012009
66Congenital hepatic fibrosis (HP:0002612)1.90752108
67Abnormal pupillary function (HP:0007686)1.89021347
68Vacuolated lymphocytes (HP:0001922)1.87946566
69Tubulointerstitial abnormality (HP:0001969)1.87257476
70Atonic seizures (HP:0010819)1.86943804
71Morphological abnormality of the inner ear (HP:0011390)1.85723140
72Progressive macrocephaly (HP:0004481)1.85714444
73Abnormality of the preputium (HP:0100587)1.85023342
74Thyroid carcinoma (HP:0002890)1.82737495
75Exotropia (HP:0000577)1.82302594
76Aplasia/hypoplasia of the uterus (HP:0008684)1.81689296
77Incomplete penetrance (HP:0003829)1.80739605
78Postaxial foot polydactyly (HP:0001830)1.80650348
79Papillary thyroid carcinoma (HP:0002895)1.80551039
80Delayed gross motor development (HP:0002194)1.80289242
81Abnormal respiratory epithelium morphology (HP:0012253)1.79807149
82Abnormal respiratory motile cilium morphology (HP:0005938)1.79807149
83Abnormality of the ischium (HP:0003174)1.79620329
84Agitation (HP:0000713)1.78612284
85Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78386842
86Male pseudohermaphroditism (HP:0000037)1.77332246
87Decreased muscle mass (HP:0003199)1.77049999
88Oligohydramnios (HP:0001562)1.75458470
89Neoplasm of head and neck (HP:0012288)1.74416815
90Esophageal neoplasm (HP:0100751)1.74416815
91Poikilocytosis (HP:0004447)1.74319972
92Abnormality of the renal cortex (HP:0011035)1.73396293
93Failure to thrive in infancy (HP:0001531)1.73180606
94Hemiparesis (HP:0001269)1.73083425
95Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72805364
96Focal dystonia (HP:0004373)1.71147915
97Abnormal neuron morphology (HP:0012757)1.70779030
98Abnormality of the motor neurons (HP:0002450)1.70779030
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.70679370
100Acute encephalopathy (HP:0006846)1.70518943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.53365481
2STK38L3.52688380
3MARK13.01047860
4MAP3K42.87182957
5TRIM282.81773457
6GRK12.78209809
7SIK32.50480438
8ADRBK22.50419599
9BCR2.44962092
10LIMK12.42906519
11PINK12.38966223
12BMPR1B2.34087274
13WNK31.83951894
14ERBB31.83057485
15MAP3K121.82469845
16LATS21.71621682
17TESK21.59666183
18FRK1.54558531
19CSNK1A1L1.48036021
20CSNK1G31.45717395
21EPHA41.42018844
22MAP2K71.41335844
23CDC71.39902732
24PIK3CA1.39808846
25STK381.36424633
26BUB11.25722514
27DYRK31.22077916
28BRD41.21206436
29MAPK131.20894260
30CSNK1G11.17019286
31ADRBK11.14127214
32CSNK1G21.10328406
33DYRK21.08949122
34STK31.08619068
35EIF2AK31.03162472
36EPHB21.03055426
37NME11.01586068
38MST1R1.01071701
39DYRK1A1.00532248
40CASK0.98192854
41CCNB10.97612570
42PRKCE0.97435151
43TESK10.89692606
44CLK10.84291645
45MKNK10.83953262
46PRKD30.83269131
47DDR20.81925754
48PLK10.81812107
49CAMK2B0.77629257
50SRPK10.71582544
51CAMK2A0.71360558
52MKNK20.71352513
53PLK20.71022705
54SIK20.69720506
55INSRR0.68884349
56DAPK20.66571397
57PRKCG0.65861584
58MAP4K20.62455354
59LMTK20.62445081
60MYLK0.60320565
61UHMK10.59482605
62EPHA20.57223479
63SIK10.55394686
64CDK30.54619202
65TGFBR10.54544127
66FGFR30.51513223
67PKN10.51355543
68CDK50.51090550
69BRSK10.50089935
70PTK2B0.49981370
71GRK70.49959965
72MAP2K40.48059659
73EIF2AK20.47354914
74TNIK0.47061584
75NTRK20.45296568
76TIE10.44848261
77TGFBR20.44431472
78KSR10.44120139
79MAP3K110.42880800
80PAK30.42666421
81NEK20.42321643
82CDK180.42096420
83MARK30.41438098
84FGFR20.41102382
85PRKACB0.40895036
86OXSR10.39493097
87NUAK10.39388915
88BCKDK0.39219422
89CAMK2G0.38834227
90BRSK20.38457554
91VRK10.38331079
92CDK11A0.35930915
93FGFR10.35338690
94PIM20.34205743
95PRKACA0.33822368
96ROCK20.33792616
97MINK10.33486898
98ZAK0.33333414
99GRK50.33272194
100CSNK1A10.33030006

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.65980617
2Phototransduction_Homo sapiens_hsa047443.18039528
3Vitamin B6 metabolism_Homo sapiens_hsa007502.96315463
4Oxidative phosphorylation_Homo sapiens_hsa001902.72954926
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.48064928
6Protein export_Homo sapiens_hsa030602.41709045
7GABAergic synapse_Homo sapiens_hsa047272.25628274
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.20705413
9Parkinsons disease_Homo sapiens_hsa050122.16878326
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11890427
11Fanconi anemia pathway_Homo sapiens_hsa034602.06766048
12Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.00887564
13Serotonergic synapse_Homo sapiens_hsa047262.00604086
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98234975
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.96039370
16Collecting duct acid secretion_Homo sapiens_hsa049661.84976637
17Butanoate metabolism_Homo sapiens_hsa006501.81001303
18Nitrogen metabolism_Homo sapiens_hsa009101.80200742
19Sphingolipid metabolism_Homo sapiens_hsa006001.77990093
20Olfactory transduction_Homo sapiens_hsa047401.77531350
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.72255821
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71372499
23Proteasome_Homo sapiens_hsa030501.71267012
24Morphine addiction_Homo sapiens_hsa050321.70583264
25Huntingtons disease_Homo sapiens_hsa050161.65934062
26Taste transduction_Homo sapiens_hsa047421.64561942
27Sulfur metabolism_Homo sapiens_hsa009201.57227956
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48732252
29Basal transcription factors_Homo sapiens_hsa030221.42256671
30Alzheimers disease_Homo sapiens_hsa050101.40444596
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38852061
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38216520
33Synaptic vesicle cycle_Homo sapiens_hsa047211.35665861
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29172580
35Hedgehog signaling pathway_Homo sapiens_hsa043401.22638358
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20204007
37Tryptophan metabolism_Homo sapiens_hsa003801.19770997
38RNA degradation_Homo sapiens_hsa030181.16331496
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14171336
40Cardiac muscle contraction_Homo sapiens_hsa042601.10801598
41beta-Alanine metabolism_Homo sapiens_hsa004101.06821165
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04828267
43Glutathione metabolism_Homo sapiens_hsa004801.04071637
44Glutamatergic synapse_Homo sapiens_hsa047240.99130398
45RNA polymerase_Homo sapiens_hsa030200.99063143
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97699827
47Histidine metabolism_Homo sapiens_hsa003400.95960323
48Vibrio cholerae infection_Homo sapiens_hsa051100.93314135
49Glycerolipid metabolism_Homo sapiens_hsa005610.92079251
50Ribosome_Homo sapiens_hsa030100.91744976
51Propanoate metabolism_Homo sapiens_hsa006400.87748579
52Basal cell carcinoma_Homo sapiens_hsa052170.87196781
53Peroxisome_Homo sapiens_hsa041460.86157615
54Cocaine addiction_Homo sapiens_hsa050300.85332011
55Nucleotide excision repair_Homo sapiens_hsa034200.83273236
56Circadian entrainment_Homo sapiens_hsa047130.82317865
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.78779399
58Pyrimidine metabolism_Homo sapiens_hsa002400.77939326
59Base excision repair_Homo sapiens_hsa034100.77547048
60Chemical carcinogenesis_Homo sapiens_hsa052040.75740724
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74123532
62Axon guidance_Homo sapiens_hsa043600.73631453
63Gap junction_Homo sapiens_hsa045400.73406781
64Hippo signaling pathway_Homo sapiens_hsa043900.72435812
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71513713
66Oocyte meiosis_Homo sapiens_hsa041140.69577280
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67946039
68Dopaminergic synapse_Homo sapiens_hsa047280.67680001
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66465950
70N-Glycan biosynthesis_Homo sapiens_hsa005100.65568489
71Metabolic pathways_Homo sapiens_hsa011000.64751989
72Spliceosome_Homo sapiens_hsa030400.64155303
73Alcoholism_Homo sapiens_hsa050340.63114774
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.61294028
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60943301
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59241942
77Salivary secretion_Homo sapiens_hsa049700.55068706
78Arginine and proline metabolism_Homo sapiens_hsa003300.51113769
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49924277
80Pyruvate metabolism_Homo sapiens_hsa006200.48882811
81Folate biosynthesis_Homo sapiens_hsa007900.45849212
82Retinol metabolism_Homo sapiens_hsa008300.44016312
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43296811
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.42533789
85Calcium signaling pathway_Homo sapiens_hsa040200.42402135
86Cell cycle_Homo sapiens_hsa041100.42125404
87Phenylalanine metabolism_Homo sapiens_hsa003600.41645576
88TGF-beta signaling pathway_Homo sapiens_hsa043500.41148398
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40503086
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39357898
91Phagosome_Homo sapiens_hsa041450.39141230
92RNA transport_Homo sapiens_hsa030130.38418404
93Fatty acid degradation_Homo sapiens_hsa000710.37784541
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37398836
95Tyrosine metabolism_Homo sapiens_hsa003500.36266487
96Arachidonic acid metabolism_Homo sapiens_hsa005900.33382860
97Homologous recombination_Homo sapiens_hsa034400.32502419
98Ether lipid metabolism_Homo sapiens_hsa005650.31648347
99Dilated cardiomyopathy_Homo sapiens_hsa054140.31382471
100Purine metabolism_Homo sapiens_hsa002300.31277899

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