C6ORF62

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.67328955
2proteasome assembly (GO:0043248)4.89130270
3response to pheromone (GO:0019236)4.02395968
4replication fork processing (GO:0031297)3.93003019
5cullin deneddylation (GO:0010388)3.91889041
6negative regulation of DNA-dependent DNA replication (GO:2000104)3.83331020
7DNA deamination (GO:0045006)3.80125578
8platelet dense granule organization (GO:0060155)3.76382665
9RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.67071504
10protein deneddylation (GO:0000338)3.61895928
11histone H2A acetylation (GO:0043968)3.54220024
12lactate metabolic process (GO:0006089)3.52821366
13respiratory chain complex IV assembly (GO:0008535)3.47675335
14somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.46219496
15isotype switching (GO:0045190)3.46219496
16somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.46219496
17synapsis (GO:0007129)3.27455797
18DNA catabolic process, exonucleolytic (GO:0000738)3.26938293
19regulation of mitotic spindle checkpoint (GO:1903504)3.18653732
20regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18653732
21exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16282010
22cell wall macromolecule catabolic process (GO:0016998)3.14872868
23histone exchange (GO:0043486)3.13828280
24cytochrome complex assembly (GO:0017004)3.12847223
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11979897
26positive regulation of protein autophosphorylation (GO:0031954)3.11340860
27histone mRNA catabolic process (GO:0071044)3.07900866
28recombinational repair (GO:0000725)3.07848503
29double-strand break repair via homologous recombination (GO:0000724)3.07495792
30attachment of spindle microtubules to kinetochore (GO:0008608)3.06086023
31regulation of meiosis I (GO:0060631)3.04527790
32keratinocyte development (GO:0003334)3.03604400
33regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99846603
34DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95824074
35branched-chain amino acid catabolic process (GO:0009083)2.94468946
36cell wall macromolecule metabolic process (GO:0044036)2.94245557
37inositol phosphate catabolic process (GO:0071545)2.93606554
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91116411
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91116411
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91116411
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86916679
42protein K6-linked ubiquitination (GO:0085020)2.86770725
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86562554
44intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.86489552
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.86489552
46regulation of DNA endoreduplication (GO:0032875)2.85923496
47chromatin remodeling at centromere (GO:0031055)2.85200463
48prenylation (GO:0097354)2.84846928
49protein prenylation (GO:0018342)2.84846928
50female gonad development (GO:0008585)2.83353356
51signal peptide processing (GO:0006465)2.81245003
52DNA replication-dependent nucleosome assembly (GO:0006335)2.81211301
53DNA replication-dependent nucleosome organization (GO:0034723)2.81211301
54maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80653024
55non-recombinational repair (GO:0000726)2.79091684
56double-strand break repair via nonhomologous end joining (GO:0006303)2.79091684
57regulation of cellular amino acid metabolic process (GO:0006521)2.78908707
58CENP-A containing nucleosome assembly (GO:0034080)2.77817726
59positive regulation of glycoprotein biosynthetic process (GO:0010560)2.77453259
60ribosome assembly (GO:0042255)2.75046984
61regulation of cilium movement (GO:0003352)2.74613373
62signal transduction involved in cell cycle checkpoint (GO:0072395)2.74465740
63mannosylation (GO:0097502)2.71346157
64detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.71005835
65regulation of acyl-CoA biosynthetic process (GO:0050812)2.70999501
66S-adenosylmethionine metabolic process (GO:0046500)2.70005440
67signal transduction involved in DNA integrity checkpoint (GO:0072401)2.69478449
68signal transduction involved in DNA damage checkpoint (GO:0072422)2.69478449
69histone mRNA metabolic process (GO:0008334)2.68216115
70protein neddylation (GO:0045116)2.67679676
71preassembly of GPI anchor in ER membrane (GO:0016254)2.66031576
72response to X-ray (GO:0010165)2.65475182
73resolution of meiotic recombination intermediates (GO:0000712)2.64506406
74retinal rod cell development (GO:0046548)2.64426668
75regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.62371643
76negative regulation of translation, ncRNA-mediated (GO:0040033)2.61935674
77regulation of translation, ncRNA-mediated (GO:0045974)2.61935674
78negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61935674
79mitochondrial DNA replication (GO:0006264)2.61164315
80anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.60219590
81water-soluble vitamin biosynthetic process (GO:0042364)2.60152537
82postreplication repair (GO:0006301)2.60085644
83metaphase plate congression (GO:0051310)2.58936231
84regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.58711966
85L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.58558632
86regulation of nuclear cell cycle DNA replication (GO:0033262)2.58007801
87protein K11-linked deubiquitination (GO:0035871)2.55289529
88polyol catabolic process (GO:0046174)2.55117460
89histone H2A ubiquitination (GO:0033522)2.55025443
90spindle checkpoint (GO:0031577)2.54841835
91regulation of sulfur metabolic process (GO:0042762)2.52925140
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.51939367
93somatic hypermutation of immunoglobulin genes (GO:0016446)2.51939367
94maturation of 5.8S rRNA (GO:0000460)2.50558653
95negative regulation of ligase activity (GO:0051352)2.50017797
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.50017797
97fucose catabolic process (GO:0019317)2.50010613
98L-fucose metabolic process (GO:0042354)2.50010613
99L-fucose catabolic process (GO:0042355)2.50010613
100negative regulation of DNA recombination (GO:0045910)2.49753712

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.46691429
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42678544
3ZNF274_21170338_ChIP-Seq_K562_Hela3.14223639
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.88744280
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.85480707
6VDR_22108803_ChIP-Seq_LS180_Human2.66917680
7* EST1_17652178_ChIP-ChIP_JURKAT_Human2.61475107
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.52293518
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48063516
10* ELK1_19687146_ChIP-ChIP_HELA_Human2.47173397
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33740068
12EWS_26573619_Chip-Seq_HEK293_Human2.19145792
13GBX2_23144817_ChIP-Seq_PC3_Human2.18315749
14FUS_26573619_Chip-Seq_HEK293_Human2.16650490
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15748915
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12198524
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09506071
18P300_19829295_ChIP-Seq_ESCs_Human2.05792288
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04074063
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03982329
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97766483
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93171701
23TAF15_26573619_Chip-Seq_HEK293_Human1.88842928
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85638876
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80576369
26EZH2_27294783_Chip-Seq_NPCs_Mouse1.79266111
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78810389
28IGF1R_20145208_ChIP-Seq_DFB_Human1.77685650
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.75446403
30* VDR_23849224_ChIP-Seq_CD4+_Human1.72267386
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66279845
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.64895469
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62880323
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62223378
35ER_23166858_ChIP-Seq_MCF-7_Human1.52390416
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51567519
37* SMAD_19615063_ChIP-ChIP_OVARY_Human1.49233918
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.46408273
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44374571
40CRX_20693478_ChIP-Seq_RETINA_Mouse1.42975447
41BCAT_22108803_ChIP-Seq_LS180_Human1.42679167
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42064690
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39332861
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38801769
45CBP_20019798_ChIP-Seq_JUKART_Human1.37185252
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37185252
47CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36954516
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36687983
49* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35795891
50FOXP3_21729870_ChIP-Seq_TREG_Human1.35571762
51E2F7_22180533_ChIP-Seq_HELA_Human1.35394758
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35087819
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32643278
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31873367
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31762894
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.31403292
57SMAD4_21799915_ChIP-Seq_A2780_Human1.31401520
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.30652154
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.30004119
60NANOG_19829295_ChIP-Seq_ESCs_Human1.28943360
61SOX2_19829295_ChIP-Seq_ESCs_Human1.28943360
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28814312
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26806593
64P53_22387025_ChIP-Seq_ESCs_Mouse1.25293046
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25179221
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24452522
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23125343
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22124278
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21482152
70* CDX2_22108803_ChIP-Seq_LS180_Human1.21429309
71* TCF4_22108803_ChIP-Seq_LS180_Human1.21132661
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.20699432
73* MYC_18940864_ChIP-ChIP_HL60_Human1.20665519
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20502215
75OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20415002
76SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.20145037
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19248210
78P300_18555785_Chip-Seq_ESCs_Mouse1.18485718
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17822214
80AR_25329375_ChIP-Seq_VCAP_Human1.16662411
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.15236085
82* ETS1_20019798_ChIP-Seq_JURKAT_Human1.13794909
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.13305248
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.12085508
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10970246
86JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10632367
87STAT3_23295773_ChIP-Seq_U87_Human1.10173014
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08569181
89TP53_22573176_ChIP-Seq_HFKS_Human1.07187975
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05651451
91OCT4_18555785_Chip-Seq_ESCs_Mouse1.04860141
92SOX2_18555785_Chip-Seq_ESCs_Mouse1.04451249
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02966924
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02790857
95TCF4_23295773_ChIP-Seq_U87_Human1.02358032
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01946162
97* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01465351
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.99569928
99SALL4_22934838_ChIP-ChIP_CD34+_Human0.98325543
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96995838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.95089067
2MP0002102_abnormal_ear_morphology3.89187028
3MP0005171_absent_coat_pigmentation3.07022749
4MP0006054_spinal_hemorrhage2.85634335
5MP0008058_abnormal_DNA_repair2.79917386
6MP0005075_abnormal_melanosome_morpholog2.79813297
7MP0008877_abnormal_DNA_methylation2.78880514
8MP0003195_calcinosis2.64517762
9MP0010094_abnormal_chromosome_stability2.63029801
10MP0002938_white_spotting2.41766163
11MP0005367_renal/urinary_system_phenotyp2.36528679
12MP0000516_abnormal_urinary_system2.36528679
13MP0003136_yellow_coat_color2.36209172
14MP0005174_abnormal_tail_pigmentation2.19037032
15MP0000015_abnormal_ear_pigmentation2.02400183
16MP0000569_abnormal_digit_pigmentation2.02059161
17MP0005408_hypopigmentation2.01132793
18MP0001984_abnormal_olfaction1.94309700
19MP0005253_abnormal_eye_physiology1.92015024
20MP0003718_maternal_effect1.91318982
21MP0002837_dystrophic_cardiac_calcinosis1.87785999
22MP0005551_abnormal_eye_electrophysiolog1.87324297
23MP0003786_premature_aging1.85879247
24MP0004147_increased_porphyrin_level1.80382104
25MP0003806_abnormal_nucleotide_metabolis1.77892372
26MP0006072_abnormal_retinal_apoptosis1.75543753
27MP0002736_abnormal_nociception_after1.71785253
28MP0001324_abnormal_eye_pigmentation1.55583054
29MP0002095_abnormal_skin_pigmentation1.50631140
30MP0002254_reproductive_system_inflammat1.49668528
31MP0003880_abnormal_central_pattern1.48886075
32MP0009697_abnormal_copulation1.44953814
33MP0003787_abnormal_imprinting1.44911438
34MP0004215_abnormal_myocardial_fiber1.44487092
35MP0001485_abnormal_pinna_reflex1.44294072
36MP0000427_abnormal_hair_cycle1.43959897
37MP0002751_abnormal_autonomic_nervous1.41484922
38MP0003890_abnormal_embryonic-extraembry1.39361208
39MP0008872_abnormal_physiological_respon1.36441701
40MP0005084_abnormal_gallbladder_morpholo1.35683605
41MP0002090_abnormal_vision1.32284559
42MP0008057_abnormal_DNA_replication1.31911921
43MP0006036_abnormal_mitochondrial_physio1.28943414
44MP0003011_delayed_dark_adaptation1.28931366
45MP0000371_diluted_coat_color1.25574713
46MP0002638_abnormal_pupillary_reflex1.24451137
47MP0001968_abnormal_touch/_nociception1.22709416
48MP0008789_abnormal_olfactory_epithelium1.22456784
49MP0000647_abnormal_sebaceous_gland1.20675878
50MP0004381_abnormal_hair_follicle1.19387024
51MP0003950_abnormal_plasma_membrane1.15206477
52MP0005248_abnormal_Harderian_gland1.14013578
53MP0008007_abnormal_cellular_replicative1.13206814
54MP0003693_abnormal_embryo_hatching1.11675185
55MP0004957_abnormal_blastocyst_morpholog1.07919527
56MP0003137_abnormal_impulse_conducting1.07441435
57MP0003567_abnormal_fetal_cardiomyocyte1.07198474
58MP0001529_abnormal_vocalization1.05888793
59MP0003186_abnormal_redox_activity1.03138081
60MP0005395_other_phenotype1.02011983
61MP0003111_abnormal_nucleus_morphology1.01243670
62MP0010234_abnormal_vibrissa_follicle0.99119446
63MP0001764_abnormal_homeostasis0.97931597
64MP0001929_abnormal_gametogenesis0.95981501
65MP0008775_abnormal_heart_ventricle0.94658410
66MP0005332_abnormal_amino_acid0.89936680
67MP0006035_abnormal_mitochondrial_morpho0.89796615
68MP0003121_genomic_imprinting0.87943593
69MP0008875_abnormal_xenobiotic_pharmacok0.85648214
70MP0001293_anophthalmia0.85511648
71MP0001119_abnormal_female_reproductive0.83667665
72MP0003646_muscle_fatigue0.83496403
73MP0005646_abnormal_pituitary_gland0.81994166
74MP0001486_abnormal_startle_reflex0.80911692
75MP0002233_abnormal_nose_morphology0.80673266
76MP0003077_abnormal_cell_cycle0.80646732
77MP0000653_abnormal_sex_gland0.78653912
78MP0006292_abnormal_olfactory_placode0.77312340
79MP0000538_abnormal_urinary_bladder0.76489226
80MP0005645_abnormal_hypothalamus_physiol0.76139697
81MP0009046_muscle_twitch0.74259280
82MP0008932_abnormal_embryonic_tissue0.71715539
83MP0010307_abnormal_tumor_latency0.70217225
84MP0005394_taste/olfaction_phenotype0.69598227
85MP0005499_abnormal_olfactory_system0.69598227
86MP0002210_abnormal_sex_determination0.69113952
87MP0001986_abnormal_taste_sensitivity0.68310014
88MP0000613_abnormal_salivary_gland0.67412990
89MP0005187_abnormal_penis_morphology0.66669457
90MP0005379_endocrine/exocrine_gland_phen0.66580242
91MP0002876_abnormal_thyroid_physiology0.66304572
92MP0002272_abnormal_nervous_system0.63702921
93MP0005389_reproductive_system_phenotype0.63337352
94MP0000631_abnormal_neuroendocrine_gland0.63158556
95MP0003943_abnormal_hepatobiliary_system0.63129418
96MP0005391_vision/eye_phenotype0.62911142
97MP0002163_abnormal_gland_morphology0.62342011
98MP0005386_behavior/neurological_phenoty0.62289652
99MP0004924_abnormal_behavior0.62289652
100MP0004043_abnormal_pH_regulation0.62184353

Predicted human phenotypes

RankGene SetZ-score
1Intestinal atresia (HP:0011100)3.26014967
2Pancreatic cysts (HP:0001737)3.14993604
3Methylmalonic acidemia (HP:0002912)3.08448536
4Aplasia/Hypoplasia of the fovea (HP:0008060)2.98206552
5Hypoplasia of the fovea (HP:0007750)2.98206552
6Neoplasm of the adrenal cortex (HP:0100641)2.98069334
7Volvulus (HP:0002580)2.87083928
8Ependymoma (HP:0002888)2.85274559
9Abnormality of midbrain morphology (HP:0002418)2.78790617
10Molar tooth sign on MRI (HP:0002419)2.78790617
11Neoplasm of the adrenal gland (HP:0100631)2.76776250
12Abnormality of chromosome stability (HP:0003220)2.70965573
13Pancreatic fibrosis (HP:0100732)2.68876146
14Thyroiditis (HP:0100646)2.66174748
15Progressive inability to walk (HP:0002505)2.65170315
16Abnormality of the fovea (HP:0000493)2.63509382
17Patchy hypopigmentation of hair (HP:0011365)2.60673352
18Methylmalonic aciduria (HP:0012120)2.58946655
19True hermaphroditism (HP:0010459)2.57599784
20Abnormality of the renal cortex (HP:0011035)2.52829040
21Congenital stationary night blindness (HP:0007642)2.51075609
22Renal cortical cysts (HP:0000803)2.50675717
23Abnormality of aspartate family amino acid metabolism (HP:0010899)2.50628785
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.49250807
25Hypothermia (HP:0002045)2.48170667
26Meckel diverticulum (HP:0002245)2.47317669
27Medial flaring of the eyebrow (HP:0010747)2.45364923
28Glioma (HP:0009733)2.44333966
29Astrocytoma (HP:0009592)2.43214482
30Abnormality of the astrocytes (HP:0100707)2.43214482
31Abnormality of the labia minora (HP:0012880)2.42653043
32Albinism (HP:0001022)2.42038908
33Abnormality of the ileum (HP:0001549)2.41818144
34Progressive macrocephaly (HP:0004481)2.30712308
35Abnormality of vitamin B metabolism (HP:0004340)2.25009931
36Abnormality of methionine metabolism (HP:0010901)2.24807085
37White forelock (HP:0002211)2.23603169
38Increased CSF lactate (HP:0002490)2.20435969
39Aplasia/Hypoplasia of the macula (HP:0008059)2.20242149
40Nephronophthisis (HP:0000090)2.19701671
41Abolished electroretinogram (ERG) (HP:0000550)2.17593574
42Cutaneous melanoma (HP:0012056)2.17376799
43Colon cancer (HP:0003003)2.17189044
44Acute encephalopathy (HP:0006846)2.15512123
45Acute necrotizing encephalopathy (HP:0006965)2.14025893
46Abnormality of the preputium (HP:0100587)2.09716647
47Abnormality of the vitamin B12 metabolism (HP:0004341)2.06931617
48Abnormality of the duodenum (HP:0002246)2.06637703
49Aplasia/Hypoplasia affecting the retina (HP:0008061)2.05212856
50Hypoproteinemia (HP:0003075)2.05071240
51Small intestinal stenosis (HP:0012848)2.04756618
52Duodenal stenosis (HP:0100867)2.04756618
53Tongue fasciculations (HP:0001308)2.02316261
54Congenital sensorineural hearing impairment (HP:0008527)2.02201871
55Bifid tongue (HP:0010297)2.00558180
56Abnormal lung lobation (HP:0002101)2.00067044
57Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96094983
58Gaze-evoked nystagmus (HP:0000640)1.95364288
59Mitochondrial inheritance (HP:0001427)1.92806834
60Abnormality of the renal medulla (HP:0100957)1.92389648
61Sloping forehead (HP:0000340)1.89728049
62Small hand (HP:0200055)1.86357704
63Gastrointestinal atresia (HP:0002589)1.84601977
64Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84587181
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.84372659
66Posterior subcapsular cataract (HP:0007787)1.83387385
67Clubbing of toes (HP:0100760)1.83010585
68Abnormality of serum amino acid levels (HP:0003112)1.82889486
69Pancreatic islet-cell hyperplasia (HP:0004510)1.81970614
70Abnormality of glycolysis (HP:0004366)1.79820900
71Chromsome breakage (HP:0040012)1.79689722
72Increased hepatocellular lipid droplets (HP:0006565)1.77736660
73Type I transferrin isoform profile (HP:0003642)1.77197400
74Nephrogenic diabetes insipidus (HP:0009806)1.76797451
75Congenital primary aphakia (HP:0007707)1.76436431
76Hyperglycinemia (HP:0002154)1.76429609
77Congenital, generalized hypertrichosis (HP:0004540)1.75989858
78Hyperventilation (HP:0002883)1.75773619
79Astigmatism (HP:0000483)1.75617553
80Generalized hypopigmentation (HP:0007513)1.74935331
81Genital tract atresia (HP:0001827)1.74311107
82Inability to walk (HP:0002540)1.73485437
83Aplasia/Hypoplasia of the tibia (HP:0005772)1.71944155
84Rhabdomyosarcoma (HP:0002859)1.70755914
85Aqueductal stenosis (HP:0002410)1.69465774
86Abnormality of B cell number (HP:0010975)1.68990815
87Adrenal hypoplasia (HP:0000835)1.68501308
88Attenuation of retinal blood vessels (HP:0007843)1.66574437
89Gait imbalance (HP:0002141)1.66436269
90Abnormal protein glycosylation (HP:0012346)1.66409020
91Abnormal glycosylation (HP:0012345)1.66409020
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66409020
93Abnormal protein N-linked glycosylation (HP:0012347)1.66409020
94Lipid accumulation in hepatocytes (HP:0006561)1.66269073
95Hepatocellular necrosis (HP:0001404)1.64311879
96Short tibia (HP:0005736)1.64169977
97Breast carcinoma (HP:0003002)1.63301266
98Median cleft lip (HP:0000161)1.62934920
99Disproportionate short-trunk short stature (HP:0003521)1.62539510
100B lymphocytopenia (HP:0010976)1.62472775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.28817520
2FRK3.94146372
3EIF2AK33.49921664
4WNK33.22148698
5ACVR1B2.93686586
6NUAK12.77639845
7BMPR1B2.70826288
8EIF2AK12.53450487
9ERBB32.50656027
10MST42.45959289
11SIK32.35641171
12BUB12.28729653
13MAP4K22.28320510
14MKNK22.24859555
15NEK12.22458590
16WEE12.11020862
17BCR2.02007617
18PLK32.01832916
19PLK21.98185888
20BRSK21.76399460
21TNIK1.73028565
22TSSK61.65810615
23MKNK11.56954509
24MAPK131.54076398
25ZAK1.45285526
26PLK41.35313922
27GRK11.30495668
28PAK31.28116738
29STK391.22284216
30SRPK11.20968830
31FER1.16542333
32OXSR11.11370999
33TGFBR11.04007919
34FGFR21.03832188
35TTK1.03415480
36CSNK1G10.99766944
37ADRBK20.98310539
38EIF2AK20.97750094
39VRK20.95184685
40PDK20.93258315
41CSNK1G20.92206326
42CASK0.90938800
43VRK10.87307138
44CSNK1G30.86499735
45PBK0.84035300
46INSRR0.82772669
47CCNB10.81553001
48PNCK0.77901140
49PLK10.76088297
50STK30.76063120
51STK38L0.75420803
52PRKCE0.71722177
53CSNK1A1L0.67036315
54MINK10.65151548
55MARK30.64840086
56BRSK10.62294063
57TAF10.60798358
58PINK10.59862411
59NLK0.54903795
60ATM0.52847379
61STK160.52408840
62MUSK0.51585955
63PRKD30.50735357
64TXK0.50170552
65BCKDK0.49807149
66TGFBR20.46983414
67FGFR10.45101406
68EPHA40.44581636
69TAOK30.43845682
70MAP3K120.41646149
71STK100.41161133
72MAP3K40.38877023
73ATR0.38224318
74PRKCG0.37897505
75KSR10.37696509
76ADRBK10.37449935
77GRK50.36959082
78PRKCI0.36173560
79PTK2B0.35247867
80ERBB40.34616059
81MAPKAPK50.34577467
82TEC0.30867005
83MAPKAPK30.30814399
84GRK70.30505063
85IGF1R0.29766279
86ABL10.29759463
87CSNK1A10.28599078
88FLT30.28263387
89PKN10.27998117
90MARK10.26734377
91CAMK2A0.26583650
92DYRK20.26219128
93PHKG20.25493404
94PHKG10.25493404
95PRKCQ0.24519980
96ROCK10.24468489
97CSNK2A10.24118858
98CSNK1D0.24085469
99YES10.23199747
100DAPK10.22790165

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.96108958
2Protein export_Homo sapiens_hsa030603.75206219
3Non-homologous end-joining_Homo sapiens_hsa034503.19727044
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.88900758
5Propanoate metabolism_Homo sapiens_hsa006402.81034302
6Homologous recombination_Homo sapiens_hsa034402.41691735
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.38100105
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33774668
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29401412
10Fanconi anemia pathway_Homo sapiens_hsa034602.28931095
11Basal transcription factors_Homo sapiens_hsa030222.27208677
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22270405
13RNA degradation_Homo sapiens_hsa030181.95781505
14Steroid biosynthesis_Homo sapiens_hsa001001.95471781
15Butanoate metabolism_Homo sapiens_hsa006501.92342668
16Caffeine metabolism_Homo sapiens_hsa002321.90415228
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85349361
18Mismatch repair_Homo sapiens_hsa034301.81826125
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81546310
20Selenocompound metabolism_Homo sapiens_hsa004501.79750584
21Fatty acid elongation_Homo sapiens_hsa000621.69749263
22RNA polymerase_Homo sapiens_hsa030201.68489591
23Phototransduction_Homo sapiens_hsa047441.45704458
24Vitamin B6 metabolism_Homo sapiens_hsa007501.43096811
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34788282
26Sulfur metabolism_Homo sapiens_hsa009201.31615927
27Nitrogen metabolism_Homo sapiens_hsa009101.31173757
28RNA transport_Homo sapiens_hsa030131.29640950
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28289176
30Tryptophan metabolism_Homo sapiens_hsa003801.24514755
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.22873567
32Oxidative phosphorylation_Homo sapiens_hsa001901.20153160
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18352050
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.16768349
35Peroxisome_Homo sapiens_hsa041461.16756515
36Parkinsons disease_Homo sapiens_hsa050121.10717802
37One carbon pool by folate_Homo sapiens_hsa006701.09989707
38Nucleotide excision repair_Homo sapiens_hsa034201.08662462
39Oocyte meiosis_Homo sapiens_hsa041141.06011768
40p53 signaling pathway_Homo sapiens_hsa041151.01681419
41Ether lipid metabolism_Homo sapiens_hsa005651.01077074
42Glutathione metabolism_Homo sapiens_hsa004800.97732471
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94833556
44Collecting duct acid secretion_Homo sapiens_hsa049660.94336079
45Fatty acid metabolism_Homo sapiens_hsa012120.94036253
46Fatty acid degradation_Homo sapiens_hsa000710.92268329
47Regulation of autophagy_Homo sapiens_hsa041400.88398914
48Cell cycle_Homo sapiens_hsa041100.86964011
49beta-Alanine metabolism_Homo sapiens_hsa004100.84034037
50Purine metabolism_Homo sapiens_hsa002300.80145385
51Pyruvate metabolism_Homo sapiens_hsa006200.79910956
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79193989
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77541049
54Linoleic acid metabolism_Homo sapiens_hsa005910.77398194
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77250663
56Chemical carcinogenesis_Homo sapiens_hsa052040.76339125
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74929322
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73321276
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73236540
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72441956
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72376334
62Base excision repair_Homo sapiens_hsa034100.71172472
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70191740
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69435438
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67065744
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66853511
67Retinol metabolism_Homo sapiens_hsa008300.64353034
68DNA replication_Homo sapiens_hsa030300.63858206
69Metabolic pathways_Homo sapiens_hsa011000.63143178
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61242979
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60539904
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.60278908
73Spliceosome_Homo sapiens_hsa030400.58273868
74Pyrimidine metabolism_Homo sapiens_hsa002400.57835551
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55276239
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52941104
77Legionellosis_Homo sapiens_hsa051340.52938585
78Huntingtons disease_Homo sapiens_hsa050160.52260761
79Olfactory transduction_Homo sapiens_hsa047400.45718827
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44980661
81Circadian rhythm_Homo sapiens_hsa047100.44357486
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43738785
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42029187
84TGF-beta signaling pathway_Homo sapiens_hsa043500.41116539
85Alzheimers disease_Homo sapiens_hsa050100.40587869
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.38843724
87mRNA surveillance pathway_Homo sapiens_hsa030150.38653475
88Sphingolipid metabolism_Homo sapiens_hsa006000.36670065
89Fat digestion and absorption_Homo sapiens_hsa049750.36487535
90Arachidonic acid metabolism_Homo sapiens_hsa005900.35763508
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.34537927
92Mineral absorption_Homo sapiens_hsa049780.33537255
93N-Glycan biosynthesis_Homo sapiens_hsa005100.32946849
94Glycerolipid metabolism_Homo sapiens_hsa005610.32137458
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31478763
96Type I diabetes mellitus_Homo sapiens_hsa049400.31269394
97Carbon metabolism_Homo sapiens_hsa012000.26492752
98Asthma_Homo sapiens_hsa053100.25243429
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25203721
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22911230

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