C6orf141

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.46667883
2fucose catabolic process (GO:0019317)4.61156740
3L-fucose metabolic process (GO:0042354)4.61156740
4L-fucose catabolic process (GO:0042355)4.61156740
5kynurenine metabolic process (GO:0070189)4.11544299
6DNA deamination (GO:0045006)4.03516764
7indole-containing compound catabolic process (GO:0042436)3.75496522
8indolalkylamine catabolic process (GO:0046218)3.75496522
9tryptophan catabolic process (GO:0006569)3.75496522
10preassembly of GPI anchor in ER membrane (GO:0016254)3.75480181
11negative regulation of telomere maintenance (GO:0032205)3.68630152
12regulation of nuclear cell cycle DNA replication (GO:0033262)3.67634660
13piRNA metabolic process (GO:0034587)3.53577475
14water-soluble vitamin biosynthetic process (GO:0042364)3.45765094
15respiratory chain complex IV assembly (GO:0008535)3.45407127
16indolalkylamine metabolic process (GO:0006586)3.36053833
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.30988079
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.24874680
19pseudouridine synthesis (GO:0001522)3.22408730
20tryptophan metabolic process (GO:0006568)3.22405404
21protein complex biogenesis (GO:0070271)3.20988264
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.16517249
23NADH dehydrogenase complex assembly (GO:0010257)3.16517249
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16517249
25mannosylation (GO:0097502)3.16179641
26cellular ketone body metabolic process (GO:0046950)3.14382504
27mitochondrial respiratory chain complex assembly (GO:0033108)3.06640148
28response to pheromone (GO:0019236)3.03526132
29protein-cofactor linkage (GO:0018065)2.99450812
30cytochrome complex assembly (GO:0017004)2.96224480
31ubiquinone biosynthetic process (GO:0006744)2.91167213
32nephron tubule morphogenesis (GO:0072078)2.88495945
33nephron epithelium morphogenesis (GO:0072088)2.88495945
34kidney morphogenesis (GO:0060993)2.83438106
35RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83368200
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83368200
37recombinational repair (GO:0000725)2.82679748
38regulation of mesoderm development (GO:2000380)2.82663258
39cornea development in camera-type eye (GO:0061303)2.80040976
40regulation of hippo signaling (GO:0035330)2.79276303
41ubiquinone metabolic process (GO:0006743)2.78989898
42double-strand break repair via homologous recombination (GO:0000724)2.78618643
43nonmotile primary cilium assembly (GO:0035058)2.78401810
44ketone body metabolic process (GO:1902224)2.77062096
45platelet dense granule organization (GO:0060155)2.76334075
46DNA methylation involved in gamete generation (GO:0043046)2.76067987
47GPI anchor metabolic process (GO:0006505)2.74535704
48tRNA modification (GO:0006400)2.71357914
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.70652300
50axoneme assembly (GO:0035082)2.69232066
51amine catabolic process (GO:0009310)2.68080047
52cellular biogenic amine catabolic process (GO:0042402)2.68080047
53peptidyl-histidine modification (GO:0018202)2.67783700
54tRNA processing (GO:0008033)2.67766581
55replication fork processing (GO:0031297)2.66247531
56DNA double-strand break processing (GO:0000729)2.65880584
57energy coupled proton transport, down electrochemical gradient (GO:0015985)2.63728700
58ATP synthesis coupled proton transport (GO:0015986)2.63728700
59negative regulation of DNA-dependent DNA replication (GO:2000104)2.61531790
60reflex (GO:0060004)2.60538198
61epithelial cilium movement (GO:0003351)2.59335865
62regulation of action potential (GO:0098900)2.58188499
63regulation of gene silencing by RNA (GO:0060966)2.57170321
64regulation of posttranscriptional gene silencing (GO:0060147)2.57170321
65regulation of gene silencing by miRNA (GO:0060964)2.57170321
66protein K6-linked ubiquitination (GO:0085020)2.57128677
67glycerophospholipid catabolic process (GO:0046475)2.57100279
68reciprocal DNA recombination (GO:0035825)2.57037285
69reciprocal meiotic recombination (GO:0007131)2.57037285
70indole-containing compound metabolic process (GO:0042430)2.54695688
71cilium morphogenesis (GO:0060271)2.54497462
72photoreceptor cell maintenance (GO:0045494)2.52252217
73neuronal action potential (GO:0019228)2.51267280
74L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51052372
75regulation of cilium movement (GO:0003352)2.50671276
76male meiosis I (GO:0007141)2.50544840
77phosphatidylinositol acyl-chain remodeling (GO:0036149)2.50237561
78maturation of 5.8S rRNA (GO:0000460)2.48635887
79C-terminal protein amino acid modification (GO:0018410)2.48429481
80regulation of telomere maintenance (GO:0032204)2.48122324
81multicellular organism reproduction (GO:0032504)2.46856629
82C-terminal protein lipidation (GO:0006501)2.46568165
83regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45443650
84cardiac right ventricle morphogenesis (GO:0003215)2.45355558
85GPI anchor biosynthetic process (GO:0006506)2.43079999
86auditory receptor cell stereocilium organization (GO:0060088)2.42474747
87somatic diversification of immune receptors via somatic mutation (GO:0002566)2.41768350
88somatic hypermutation of immunoglobulin genes (GO:0016446)2.41768350
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.41402981
90cilium organization (GO:0044782)2.39682226
91behavioral response to ethanol (GO:0048149)2.39411371
92regulation of hexokinase activity (GO:1903299)2.38979222
93regulation of glucokinase activity (GO:0033131)2.38979222
94fucosylation (GO:0036065)2.37695774
95detection of light stimulus involved in visual perception (GO:0050908)2.35907731
96detection of light stimulus involved in sensory perception (GO:0050962)2.35907731
97rhodopsin mediated signaling pathway (GO:0016056)2.35783293
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.35771844
99negative regulation of transcription regulatory region DNA binding (GO:2000678)2.35191206
100keratinocyte development (GO:0003334)2.35131717

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.80164348
2VDR_22108803_ChIP-Seq_LS180_Human3.40098349
3HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89318661
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.57591319
5IGF1R_20145208_ChIP-Seq_DFB_Human2.50924148
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44601432
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.40442389
8GBX2_23144817_ChIP-Seq_PC3_Human2.33275450
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32494920
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31092837
11ER_23166858_ChIP-Seq_MCF-7_Human2.27991777
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18514942
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.15341272
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10670302
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07948534
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.05731675
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04765673
18EWS_26573619_Chip-Seq_HEK293_Human2.04201309
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.02723765
20MYC_18940864_ChIP-ChIP_HL60_Human1.94057652
21FUS_26573619_Chip-Seq_HEK293_Human1.92986794
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90028822
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86709060
24IRF1_19129219_ChIP-ChIP_H3396_Human1.75475566
25TP53_22573176_ChIP-Seq_HFKS_Human1.75297652
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74992511
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71766889
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70279008
29P300_19829295_ChIP-Seq_ESCs_Human1.68970833
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.58693649
31ELK1_19687146_ChIP-ChIP_HELA_Human1.55114128
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53976879
33TAF15_26573619_Chip-Seq_HEK293_Human1.52881873
34FOXA1_25329375_ChIP-Seq_VCAP_Human1.51232230
35FOXA1_27270436_Chip-Seq_PROSTATE_Human1.51232230
36HOXB7_26014856_ChIP-Seq_BT474_Human1.49432991
37VDR_23849224_ChIP-Seq_CD4+_Human1.47119457
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46036597
39GATA3_21878914_ChIP-Seq_MCF-7_Human1.44771415
40BCAT_22108803_ChIP-Seq_LS180_Human1.39343522
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.35139123
42* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34225038
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33681037
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29927266
45AR_20517297_ChIP-Seq_VCAP_Human1.28263885
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27866150
47AR_25329375_ChIP-Seq_VCAP_Human1.26396604
48CBP_20019798_ChIP-Seq_JUKART_Human1.25582672
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25582672
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24536287
51SOX2_19829295_ChIP-Seq_ESCs_Human1.23894630
52NANOG_19829295_ChIP-Seq_ESCs_Human1.23894630
53* ESR1_21235772_ChIP-Seq_MCF-7_Human1.21946251
54* ERA_21632823_ChIP-Seq_H3396_Human1.21183933
55TCF4_23295773_ChIP-Seq_U87_Human1.19862822
56TCF4_22108803_ChIP-Seq_LS180_Human1.19542269
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19540326
58EZH2_22144423_ChIP-Seq_EOC_Human1.19503446
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17812480
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16105789
61STAT3_23295773_ChIP-Seq_U87_Human1.15951037
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14477947
63NCOR_22424771_ChIP-Seq_293T_Human1.13262120
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12244409
65TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12235369
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.11464689
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10833124
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10790947
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10367617
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10367617
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09161571
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09091960
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08593742
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.08534631
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07137724
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.06573947
77RNF2_27304074_Chip-Seq_NSC_Mouse1.05977230
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05709551
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.05260174
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04147492
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03511395
82REST_21632747_ChIP-Seq_MESCs_Mouse1.03486521
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03256176
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02634422
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02191755
86SMAD4_21799915_ChIP-Seq_A2780_Human1.01548336
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.01004147
88FOXP3_21729870_ChIP-Seq_TREG_Human0.99429749
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98599367
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98329913
91RUNX2_22187159_ChIP-Seq_PCA_Human0.98092311
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.95208571
93P53_21459846_ChIP-Seq_SAOS-2_Human0.94387704
94* ARNT_22903824_ChIP-Seq_MCF-7_Human0.94382584
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94253071
96MYC_19829295_ChIP-Seq_ESCs_Human0.93835731
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93496723
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92282477
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.91471036
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91469940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.23524656
2MP0008877_abnormal_DNA_methylation2.98227053
3MP0000427_abnormal_hair_cycle2.60120545
4MP0003195_calcinosis2.51546121
5MP0008875_abnormal_xenobiotic_pharmacok2.42399769
6MP0000383_abnormal_hair_follicle2.20269906
7MP0001968_abnormal_touch/_nociception2.18140001
8MP0005551_abnormal_eye_electrophysiolog2.10847779
9MP0002102_abnormal_ear_morphology2.08870726
10MP0002876_abnormal_thyroid_physiology2.07189022
11MP0000566_synostosis2.05988194
12MP0008872_abnormal_physiological_respon2.02033429
13MP0002736_abnormal_nociception_after1.95784675
14MP0002938_white_spotting1.88917049
15MP0003011_delayed_dark_adaptation1.88237644
16MP0003880_abnormal_central_pattern1.83812981
17MP0002837_dystrophic_cardiac_calcinosis1.83762444
18MP0003136_yellow_coat_color1.76647795
19MP0004133_heterotaxia1.74538116
20MP0006072_abnormal_retinal_apoptosis1.72369322
21MP0009046_muscle_twitch1.71578093
22MP0005377_hearing/vestibular/ear_phenot1.67603662
23MP0003878_abnormal_ear_physiology1.67603662
24MP0005646_abnormal_pituitary_gland1.67057350
25MP0002653_abnormal_ependyma_morphology1.66847273
26MP0000647_abnormal_sebaceous_gland1.65287911
27MP0003787_abnormal_imprinting1.61002999
28MP0001529_abnormal_vocalization1.58200608
29MP0004885_abnormal_endolymph1.52749580
30MP0000579_abnormal_nail_morphology1.52103587
31MP0001485_abnormal_pinna_reflex1.51464406
32MP0010678_abnormal_skin_adnexa1.46957554
33MP0005253_abnormal_eye_physiology1.46344115
34MP0000569_abnormal_digit_pigmentation1.46020652
35MP0004147_increased_porphyrin_level1.45514902
36MP0004043_abnormal_pH_regulation1.44879141
37MP0002160_abnormal_reproductive_system1.44523763
38MP0002234_abnormal_pharynx_morphology1.40523851
39MP0005645_abnormal_hypothalamus_physiol1.36695073
40MP0008058_abnormal_DNA_repair1.36428182
41MP0003646_muscle_fatigue1.36283471
42MP0002277_abnormal_respiratory_mucosa1.33745482
43MP0004142_abnormal_muscle_tone1.33201018
44MP0000372_irregular_coat_pigmentation1.32174979
45MP0009745_abnormal_behavioral_response1.29182033
46MP0002751_abnormal_autonomic_nervous1.28844990
47MP0002163_abnormal_gland_morphology1.28438227
48MP0001919_abnormal_reproductive_system1.27901778
49MP0009780_abnormal_chondrocyte_physiolo1.27156031
50MP0000631_abnormal_neuroendocrine_gland1.25618346
51MP0005389_reproductive_system_phenotype1.24374636
52MP0001293_anophthalmia1.24200326
53MP0008995_early_reproductive_senescence1.22610337
54MP0002098_abnormal_vibrissa_morphology1.21337680
55MP0003937_abnormal_limbs/digits/tail_de1.19716124
56MP0008789_abnormal_olfactory_epithelium1.12642477
57MP0010030_abnormal_orbit_morphology1.11881170
58MP0001986_abnormal_taste_sensitivity1.11291931
59MP0005084_abnormal_gallbladder_morpholo1.11181959
60MP0002272_abnormal_nervous_system1.09759526
61MP0001984_abnormal_olfaction1.08031531
62MP0002638_abnormal_pupillary_reflex1.07943478
63MP0003718_maternal_effect1.07030009
64MP0006276_abnormal_autonomic_nervous1.04321156
65MP0003890_abnormal_embryonic-extraembry1.03316535
66MP0003119_abnormal_digestive_system1.03029780
67MP0002254_reproductive_system_inflammat0.99089120
68MP0005379_endocrine/exocrine_gland_phen0.98334561
69MP0003938_abnormal_ear_development0.97352774
70MP0005195_abnormal_posterior_eye0.97158706
71MP0005410_abnormal_fertilization0.95512524
72MP0003121_genomic_imprinting0.94745691
73MP0000049_abnormal_middle_ear0.94507277
74MP0008775_abnormal_heart_ventricle0.94382034
75MP0002928_abnormal_bile_duct0.94327476
76MP0000538_abnormal_urinary_bladder0.92532528
77MP0002184_abnormal_innervation0.91745209
78MP0001905_abnormal_dopamine_level0.90811505
79MP0003122_maternal_imprinting0.90733348
80MP0001486_abnormal_startle_reflex0.89978196
81MP0001502_abnormal_circadian_rhythm0.89622364
82MP0000026_abnormal_inner_ear0.89299060
83MP0001873_stomach_inflammation0.86333583
84MP0002210_abnormal_sex_determination0.86104893
85MP0005075_abnormal_melanosome_morpholog0.86011259
86MP0002752_abnormal_somatic_nervous0.84378403
87MP0002572_abnormal_emotion/affect_behav0.83523445
88MP0002138_abnormal_hepatobiliary_system0.83184228
89MP0003936_abnormal_reproductive_system0.83011410
90MP0004742_abnormal_vestibular_system0.82231506
91MP0003786_premature_aging0.81427596
92MP0003283_abnormal_digestive_organ0.81373997
93MP0001929_abnormal_gametogenesis0.81257735
94MP0003698_abnormal_male_reproductive0.81027738
95MP0002557_abnormal_social/conspecific_i0.80597125
96MP0002095_abnormal_skin_pigmentation0.80467006
97MP0010094_abnormal_chromosome_stability0.80108992
98MP0005386_behavior/neurological_phenoty0.79394479
99MP0004924_abnormal_behavior0.79394479
100MP0005220_abnormal_exocrine_pancreas0.79304755

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.58119518
2Pancreatic fibrosis (HP:0100732)3.90173915
3True hermaphroditism (HP:0010459)3.83816745
4Abnormality of midbrain morphology (HP:0002418)3.81748815
5Molar tooth sign on MRI (HP:0002419)3.81748815
6Type II lissencephaly (HP:0007260)3.74606680
7Congenital stationary night blindness (HP:0007642)3.51061857
8Nephronophthisis (HP:0000090)3.26275352
9Cystic liver disease (HP:0006706)3.12391339
10Pendular nystagmus (HP:0012043)3.11844434
11Concave nail (HP:0001598)2.88661869
12Abnormality of the renal medulla (HP:0100957)2.83399719
13Abnormality of the renal cortex (HP:0011035)2.68883244
14Cerebellar dysplasia (HP:0007033)2.68091983
15Sclerocornea (HP:0000647)2.58254705
16Aplasia/Hypoplasia of the tongue (HP:0010295)2.52750982
17Chronic hepatic failure (HP:0100626)2.51261904
18Medial flaring of the eyebrow (HP:0010747)2.51126609
19Tubular atrophy (HP:0000092)2.50529571
20Furrowed tongue (HP:0000221)2.48846056
21Congenital, generalized hypertrichosis (HP:0004540)2.47867136
22Large for gestational age (HP:0001520)2.47680231
23Patellar aplasia (HP:0006443)2.45960704
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41429855
25Abnormality of alanine metabolism (HP:0010916)2.41429855
26Hyperalaninemia (HP:0003348)2.41429855
27Lissencephaly (HP:0001339)2.40375763
28Hyperventilation (HP:0002883)2.36780102
29Attenuation of retinal blood vessels (HP:0007843)2.35670694
30Severe muscular hypotonia (HP:0006829)2.33463945
31Abnormality of the labia minora (HP:0012880)2.32527283
32Mitochondrial inheritance (HP:0001427)2.31637222
33Aplasia/Hypoplasia of the patella (HP:0006498)2.31195056
34Hyperglycinuria (HP:0003108)2.29847597
35Abolished electroretinogram (ERG) (HP:0000550)2.27514163
36Increased CSF lactate (HP:0002490)2.23561924
37Polydipsia (HP:0001959)2.23153854
38Abnormal drinking behavior (HP:0030082)2.23153854
39Acute necrotizing encephalopathy (HP:0006965)2.22660445
40Aplasia/hypoplasia of the uterus (HP:0008684)2.22653191
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.20285698
42Inability to walk (HP:0002540)2.20270412
43Abnormality of the pons (HP:0007361)2.19617287
44Abnormal biliary tract physiology (HP:0012439)2.17037825
45Bile duct proliferation (HP:0001408)2.17037825
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16328807
47Optic nerve hypoplasia (HP:0000609)2.14188768
48Congenital hepatic fibrosis (HP:0002612)2.12555034
49Bilateral microphthalmos (HP:0007633)2.12515542
50Amelogenesis imperfecta (HP:0000705)2.11669141
513-Methylglutaconic aciduria (HP:0003535)2.09423668
52Keratoconus (HP:0000563)2.09029050
53Increased corneal curvature (HP:0100692)2.09029050
54Anencephaly (HP:0002323)2.07348355
55Postaxial foot polydactyly (HP:0001830)2.05608780
56Abnormal rod and cone electroretinograms (HP:0008323)2.05110901
57Acute encephalopathy (HP:0006846)2.04899592
58Abnormality of the ileum (HP:0001549)2.04861910
59Progressive inability to walk (HP:0002505)2.04080558
60Meckel diverticulum (HP:0002245)2.03721983
61Hypoplasia of the pons (HP:0012110)2.01021772
62Hepatocellular necrosis (HP:0001404)2.00725147
63Decreased central vision (HP:0007663)1.99248022
64Lipid accumulation in hepatocytes (HP:0006561)1.98214437
65Stomach cancer (HP:0012126)1.97707507
66Progressive macrocephaly (HP:0004481)1.94707258
67Gait imbalance (HP:0002141)1.93152708
68Absent thumb (HP:0009777)1.92593867
69Retinal dysplasia (HP:0007973)1.91538207
70Congenital primary aphakia (HP:0007707)1.91448980
71Preaxial hand polydactyly (HP:0001177)1.89279848
72Male pseudohermaphroditism (HP:0000037)1.89043479
73Increased hepatocellular lipid droplets (HP:0006565)1.89016781
74Anophthalmia (HP:0000528)1.88707114
75Dandy-Walker malformation (HP:0001305)1.87905895
76Abnormal mitochondria in muscle tissue (HP:0008316)1.86690539
77Hepatic necrosis (HP:0002605)1.86016576
78Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85980698
79Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84694654
80Chromsome breakage (HP:0040012)1.84511624
81Abnormal number of erythroid precursors (HP:0012131)1.83878613
82Chorioretinal atrophy (HP:0000533)1.83675577
83Hypothermia (HP:0002045)1.83462930
84Hypoplasia of the uterus (HP:0000013)1.82743440
85Colon cancer (HP:0003003)1.80687930
86Aplasia/Hypoplasia of the tibia (HP:0005772)1.80306364
87Duplicated collecting system (HP:0000081)1.79929626
88Birth length less than 3rd percentile (HP:0003561)1.79887298
89Occipital encephalocele (HP:0002085)1.79622875
90Nephrogenic diabetes insipidus (HP:0009806)1.78751529
91Genital tract atresia (HP:0001827)1.78712628
92Abnormality of glycine metabolism (HP:0010895)1.78666641
93Abnormality of serine family amino acid metabolism (HP:0010894)1.78666641
94Vaginal atresia (HP:0000148)1.78282572
95Increased serum lactate (HP:0002151)1.75860152
96Methylmalonic acidemia (HP:0002912)1.75521663
97Polyuria (HP:0000103)1.74395404
98Renal cortical cysts (HP:0000803)1.72926890
99Tachypnea (HP:0002789)1.72111557
100Optic disc pallor (HP:0000543)1.71335768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.95264889
2BMPR1B3.27625553
3ADRBK23.26959220
4ZAK3.14008731
5TLK12.72298156
6WNK42.63454252
7WNK32.61618148
8GRK12.51737167
9MAP4K22.38461964
10MAPKAPK32.11570396
11TAOK31.96124792
12NUAK11.95034972
13ACVR1B1.90403787
14PIK3CA1.81847170
15CASK1.74004833
16MUSK1.69927627
17INSRR1.67843067
18TRIM281.66618877
19FGFR21.56497273
20MKNK21.45429518
21PINK11.43964375
22OXSR11.41991203
23EPHA21.40868791
24STK391.37751702
25VRK21.37588017
26DAPK21.35106091
27MAPK131.31754237
28MAP3K41.22986078
29PHKG11.19257808
30PHKG21.19257808
31BCKDK1.15821583
32PRKCI1.12708632
33EPHA41.12027012
34BCR1.11426266
35PRKCE1.08918644
36NME11.08103545
37CHUK1.07831511
38STK38L1.06471183
39PAK31.04809748
40ADRBK11.04566763
41DYRK21.02639624
42TGFBR11.02373383
43MST41.01113056
44MAP2K71.00843510
45CSNK1G10.95044071
46TNIK0.92253753
47CSNK1G30.91407309
48TIE10.89669589
49MKNK10.85863238
50IKBKB0.80453254
51CSNK1G20.80407549
52NEK20.78774334
53VRK10.78495878
54CSNK1A1L0.77731556
55PNCK0.77410592
56SRPK10.76733598
57MAPK150.76598683
58PRKCG0.76135481
59EIF2AK30.74686635
60BRSK20.73435050
61MET0.67610285
62STK160.66003394
63PLK30.64855390
64PLK10.61789737
65CHEK20.59949787
66ATR0.58380810
67PLK20.57014205
68LMTK20.56604104
69TXK0.55995725
70IRAK10.55764265
71RPS6KB20.55505870
72MAPKAPK50.51278869
73CSNK1A10.51234279
74WEE10.50965480
75CSNK1D0.49431250
76RPS6KA50.49246266
77MARK10.46568597
78EPHB20.46062926
79MAP2K20.43520986
80EIF2AK20.41937113
81MST1R0.41104260
82FLT30.39634858
83ERBB30.38526988
84BUB10.37435040
85PRKCZ0.37167155
86CDC70.36194481
87ATM0.35855973
88DYRK30.34982792
89TSSK60.34942255
90CAMK2D0.34824572
91SIK20.34562068
92PRKACA0.34561130
93TAF10.34202710
94LIMK10.34034986
95FER0.32772358
96PTK2B0.32148127
97CAMK2A0.32030901
98IKBKE0.31895329
99PRKCQ0.29911606
100NTRK20.29748303

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.85490348
2Phototransduction_Homo sapiens_hsa047442.70022721
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.69009367
4Homologous recombination_Homo sapiens_hsa034402.60302327
5Oxidative phosphorylation_Homo sapiens_hsa001902.53712453
6Linoleic acid metabolism_Homo sapiens_hsa005912.52636696
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.49448288
8Caffeine metabolism_Homo sapiens_hsa002322.49332896
9Nitrogen metabolism_Homo sapiens_hsa009102.43220014
10Selenocompound metabolism_Homo sapiens_hsa004502.41933593
11Protein export_Homo sapiens_hsa030602.39530142
12RNA polymerase_Homo sapiens_hsa030202.31568234
13Fanconi anemia pathway_Homo sapiens_hsa034602.23668906
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.17331985
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.10066271
16Butanoate metabolism_Homo sapiens_hsa006501.97248702
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.88797934
18Basal transcription factors_Homo sapiens_hsa030221.86577615
19Parkinsons disease_Homo sapiens_hsa050121.82986421
20Ether lipid metabolism_Homo sapiens_hsa005651.74779097
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72836511
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67244210
23Proteasome_Homo sapiens_hsa030501.52918521
24Tryptophan metabolism_Homo sapiens_hsa003801.51318311
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39483597
26RNA degradation_Homo sapiens_hsa030181.37942096
27Huntingtons disease_Homo sapiens_hsa050161.37288486
28Nicotine addiction_Homo sapiens_hsa050331.37061431
29One carbon pool by folate_Homo sapiens_hsa006701.36335894
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35277763
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32890387
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25569174
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22643822
34Taste transduction_Homo sapiens_hsa047421.20528013
35Ribosome_Homo sapiens_hsa030101.19757910
36Propanoate metabolism_Homo sapiens_hsa006401.17141807
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13813183
38Alzheimers disease_Homo sapiens_hsa050101.12328286
39Chemical carcinogenesis_Homo sapiens_hsa052041.08050428
40Olfactory transduction_Homo sapiens_hsa047401.05256455
41Pyrimidine metabolism_Homo sapiens_hsa002401.02682503
42Cardiac muscle contraction_Homo sapiens_hsa042601.02105845
43Peroxisome_Homo sapiens_hsa041461.00395827
44Nucleotide excision repair_Homo sapiens_hsa034200.95728489
45ABC transporters_Homo sapiens_hsa020100.95352404
46Retinol metabolism_Homo sapiens_hsa008300.94053437
47Arachidonic acid metabolism_Homo sapiens_hsa005900.92980958
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89746660
49Mismatch repair_Homo sapiens_hsa034300.87001193
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.86249362
51Morphine addiction_Homo sapiens_hsa050320.86122554
52beta-Alanine metabolism_Homo sapiens_hsa004100.84953802
53Purine metabolism_Homo sapiens_hsa002300.84351602
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84310176
55Ovarian steroidogenesis_Homo sapiens_hsa049130.80634633
56Sulfur metabolism_Homo sapiens_hsa009200.80308608
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78840886
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78423822
59Non-homologous end-joining_Homo sapiens_hsa034500.78185769
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.76048265
61Metabolic pathways_Homo sapiens_hsa011000.75311565
62Steroid biosynthesis_Homo sapiens_hsa001000.75125821
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73926334
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.73293932
65Sulfur relay system_Homo sapiens_hsa041220.71697229
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71572578
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71473864
68RNA transport_Homo sapiens_hsa030130.70093100
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69933388
70Regulation of autophagy_Homo sapiens_hsa041400.66971199
71Vitamin digestion and absorption_Homo sapiens_hsa049770.65949539
72Collecting duct acid secretion_Homo sapiens_hsa049660.65383534
73Insulin secretion_Homo sapiens_hsa049110.65070232
74Histidine metabolism_Homo sapiens_hsa003400.64723770
75Fat digestion and absorption_Homo sapiens_hsa049750.64071718
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63329882
77Basal cell carcinoma_Homo sapiens_hsa052170.62914146
78Serotonergic synapse_Homo sapiens_hsa047260.61344013
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60154314
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.58532584
81Glutamatergic synapse_Homo sapiens_hsa047240.55687433
82Circadian entrainment_Homo sapiens_hsa047130.51693050
83GABAergic synapse_Homo sapiens_hsa047270.51665268
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51436746
85Glycerolipid metabolism_Homo sapiens_hsa005610.48380059
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46922854
87Hedgehog signaling pathway_Homo sapiens_hsa043400.44634576
88Salivary secretion_Homo sapiens_hsa049700.43654134
89DNA replication_Homo sapiens_hsa030300.42931672
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.39810425
91Hippo signaling pathway_Homo sapiens_hsa043900.39497958
92Mineral absorption_Homo sapiens_hsa049780.39303596
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39294594
94Fatty acid elongation_Homo sapiens_hsa000620.39008428
95Base excision repair_Homo sapiens_hsa034100.38548310
96Spliceosome_Homo sapiens_hsa030400.37891054
97Arginine and proline metabolism_Homo sapiens_hsa003300.32977887
98Vitamin B6 metabolism_Homo sapiens_hsa007500.31254258
99Circadian rhythm_Homo sapiens_hsa047100.30651449
100p53 signaling pathway_Homo sapiens_hsa041150.27597495

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