C7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucocorticoid metabolic process (GO:0008211)9.76475527
2C21-steroid hormone biosynthetic process (GO:0006700)7.75091966
3androgen biosynthetic process (GO:0006702)7.30240454
4keratan sulfate catabolic process (GO:0042340)6.47985290
5cellular response to follicle-stimulating hormone stimulus (GO:0071372)6.23656654
6cellular response to antibiotic (GO:0071236)5.84050017
7cellular response to epinephrine stimulus (GO:0071872)5.79320482
8C21-steroid hormone metabolic process (GO:0008207)5.57189443
9response to follicle-stimulating hormone (GO:0032354)5.47463343
10cellular response to gonadotropin stimulus (GO:0071371)5.25913560
11progesterone metabolic process (GO:0042448)5.23821971
12extracellular matrix assembly (GO:0085029)5.17059987
13response to epinephrine (GO:0071871)5.02965569
14low-density lipoprotein particle clearance (GO:0034383)4.99720496
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.85913910
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.85913910
17regulation of apoptotic cell clearance (GO:2000425)4.78151688
18negative regulation of Rho protein signal transduction (GO:0035024)4.60400548
19skeletal muscle adaptation (GO:0043501)4.59418475
20surfactant homeostasis (GO:0043129)4.58683696
21fusion of sperm to egg plasma membrane (GO:0007342)4.46194672
22negative regulation of stress fiber assembly (GO:0051497)4.43816256
23blood vessel maturation (GO:0001955)4.40261144
24estrogen biosynthetic process (GO:0006703)4.38254940
25* regulation of complement activation (GO:0030449)4.33565046
26cellular response to toxic substance (GO:0097237)4.27527016
27response to insecticide (GO:0017085)4.26513412
28protein heterotrimerization (GO:0070208)4.20942904
29hormone biosynthetic process (GO:0042446)4.18308719
30* regulation of protein activation cascade (GO:2000257)4.13935636
31Leydig cell differentiation (GO:0033327)4.10127840
32antigen processing and presentation of endogenous antigen (GO:0019883)4.08628066
33retina vasculature morphogenesis in camera-type eye (GO:0061299)4.00644324
34regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.91366818
35androgen metabolic process (GO:0008209)3.91028595
36antigen processing and presentation via MHC class Ib (GO:0002475)3.89023890
37positive regulation of hormone biosynthetic process (GO:0046886)3.88298776
38response to gonadotropin (GO:0034698)3.86884158
39plasma membrane fusion (GO:0045026)3.77790051
40cardiac myofibril assembly (GO:0055003)3.74971639
41cellular response to cadmium ion (GO:0071276)3.72426778
42myelination in peripheral nervous system (GO:0022011)3.70356866
43peripheral nervous system axon ensheathment (GO:0032292)3.70356866
44regulation of cardioblast differentiation (GO:0051890)3.69727632
45epithelial cell-cell adhesion (GO:0090136)3.65438793
46response to methylmercury (GO:0051597)3.62244597
47regulation of endothelial cell differentiation (GO:0045601)3.56210816
48* complement activation, alternative pathway (GO:0006957)3.52870105
49benzene-containing compound metabolic process (GO:0042537)3.51094373
50regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.50319813
51chemical homeostasis within a tissue (GO:0048875)3.50047140
52positive regulation of p38MAPK cascade (GO:1900745)3.49494303
53glomerular filtration (GO:0003094)3.46367883
54response to water (GO:0009415)3.45670616
55positive regulation of endothelial cell differentiation (GO:0045603)3.44102126
56cellular response to nitric oxide (GO:0071732)3.42691029
57endothelial cell morphogenesis (GO:0001886)3.41458970
58* complement activation, classical pathway (GO:0006958)3.40115844
59response to corticosterone (GO:0051412)3.39177513
60fatty acid transmembrane transport (GO:1902001)3.38786871
61renal filtration (GO:0097205)3.38284879
62myoblast migration (GO:0051451)3.33594559
63cardiac muscle hypertrophy (GO:0003300)3.31699296
64ketone biosynthetic process (GO:0042181)3.30360447
65valine metabolic process (GO:0006573)3.29981497
66extracellular fibril organization (GO:0043206)3.24641830
67negative regulation of protein activation cascade (GO:2000258)3.23281384
68opsonization (GO:0008228)3.21479504
69regulation of p38MAPK cascade (GO:1900744)3.20342593
70myofibril assembly (GO:0030239)3.18803182
71hormone catabolic process (GO:0042447)3.18703819
72mating behavior (GO:0007617)3.18350972
73apoptotic cell clearance (GO:0043277)3.17903860
74* complement activation (GO:0006956)3.17867957
75striated muscle hypertrophy (GO:0014897)3.16282894
76negative regulation of actin filament bundle assembly (GO:0032232)3.15896163
77brown fat cell differentiation (GO:0050873)3.15558375
78negative regulation of protein autophosphorylation (GO:0031953)3.13227202
79cellular response to catecholamine stimulus (GO:0071870)3.12924155
80cellular response to monoamine stimulus (GO:0071868)3.12924155
81cornea development in camera-type eye (GO:0061303)3.11255089
82peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.08903452
83vascular endothelial growth factor signaling pathway (GO:0038084)3.07373687
84ethanol oxidation (GO:0006069)3.05242218
85positive regulation of hormone metabolic process (GO:0032352)3.05239425
86regulation of steroid hormone biosynthetic process (GO:0090030)3.04982193
87positive regulation of digestive system process (GO:0060456)3.04561152
88intracellular lipid transport (GO:0032365)3.03352181
89triglyceride catabolic process (GO:0019433)3.02456907
90ovulation (GO:0030728)3.01218795
91collagen fibril organization (GO:0030199)2.97884784
92lymphangiogenesis (GO:0001946)2.96677542
93regulation of sequestering of triglyceride (GO:0010889)2.96373131
94positive regulation of fatty acid beta-oxidation (GO:0032000)2.94867991
95morphogenesis of an endothelium (GO:0003159)2.93515331
96endothelial tube morphogenesis (GO:0061154)2.93515331
97muscle hypertrophy (GO:0014896)2.93131671
98response to mercury ion (GO:0046689)2.92113227
99multicellular organismal macromolecule metabolic process (GO:0044259)2.91751631
100adrenal gland development (GO:0030325)2.91091290
101response to monoamine (GO:0071867)2.90545419
102response to catecholamine (GO:0071869)2.90545419
103growth hormone receptor signaling pathway (GO:0060396)2.90530242
104carnitine shuttle (GO:0006853)2.89835364
105negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89072242
106regulation of cholesterol storage (GO:0010885)2.88791789
107* protein activation cascade (GO:0072376)2.88109195
108positive regulation of steroid biosynthetic process (GO:0010893)2.87736836
109carnitine transmembrane transport (GO:1902603)2.87683529
110regulation of vasculogenesis (GO:2001212)2.86605049
111negative regulation of complement activation (GO:0045916)2.86037942
112detection of molecule of bacterial origin (GO:0032490)2.85957209
113regulation of female receptivity (GO:0045924)2.85231655
114fibril organization (GO:0097435)2.84995975
115positive regulation of fatty acid oxidation (GO:0046321)2.84595546
116potassium ion export (GO:0071435)2.84354591
117multicellular organismal metabolic process (GO:0044236)2.83052246
118endothelium development (GO:0003158)2.82749953
119regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.81691051
120metanephric tubule development (GO:0072170)2.80955684
121metanephric nephron tubule development (GO:0072234)2.80955684
122negative regulation of heart growth (GO:0061117)2.80445133
123negative regulation of cardiac muscle tissue growth (GO:0055022)2.80445133
124alpha-linolenic acid metabolic process (GO:0036109)2.79988592
125collagen metabolic process (GO:0032963)2.79845393
126carnitine transport (GO:0015879)2.79746612
127amino-acid betaine transport (GO:0015838)2.79746612
128endocrine hormone secretion (GO:0060986)2.78991764
129cellular response to reactive nitrogen species (GO:1902170)2.78018330
130cardiac muscle contraction (GO:0060048)2.76432642
131cardiac muscle adaptation (GO:0014887)2.74392663
132cardiac muscle hypertrophy in response to stress (GO:0014898)2.74392663
133muscle hypertrophy in response to stress (GO:0003299)2.74392663
134positive regulation of male gonad development (GO:2000020)2.73702769
135barbed-end actin filament capping (GO:0051016)2.72529414
136neutral lipid catabolic process (GO:0046461)2.71765356
137acylglycerol catabolic process (GO:0046464)2.71765356
138homocysteine metabolic process (GO:0050667)2.70699721
139fibroblast migration (GO:0010761)2.70600361
140positive regulation of focal adhesion assembly (GO:0051894)2.70549961
141positive regulation of cell junction assembly (GO:1901890)2.70549961
142response to mineralocorticoid (GO:0051385)2.70488156
143cellular response to dexamethasone stimulus (GO:0071549)2.68462208
144hypotonic response (GO:0006971)2.68376995
145sarcomere organization (GO:0045214)2.67239823
146multicellular organismal catabolic process (GO:0044243)2.66847756
147collagen catabolic process (GO:0030574)2.66394648
148negative regulation of endothelial cell proliferation (GO:0001937)2.66024060
149lipid particle organization (GO:0034389)2.65019460
150cell migration involved in heart development (GO:0060973)2.64708307
151sulfur compound catabolic process (GO:0044273)2.64607125
152artery development (GO:0060840)2.64044132
153metanephric nephron epithelium development (GO:0072243)2.62857734
154cellular response to growth hormone stimulus (GO:0071378)2.62800735
155glomerular basement membrane development (GO:0032836)2.62323315
156cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.61318800
157positive regulation of adherens junction organization (GO:1903393)2.60467513
158response to folic acid (GO:0051593)2.60252403
159regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.59356462
160positive regulation of macrophage cytokine production (GO:0060907)2.58939114
161growth hormone secretion (GO:0030252)2.58461572
162metanephric epithelium development (GO:0072207)2.57677420
163keratan sulfate biosynthetic process (GO:0018146)2.57317039
164response to nitric oxide (GO:0071731)2.57209747
165regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57046631
166regulation of transforming growth factor beta2 production (GO:0032909)2.56514095
167negative regulation of humoral immune response (GO:0002921)2.56441179
168toxin metabolic process (GO:0009404)2.55319299
169positive regulation of renal sodium excretion (GO:0035815)2.54813416
170muscle cell migration (GO:0014812)2.54006426
171response to growth hormone (GO:0060416)2.53970497
172neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.53714150
173ventricular cardiac muscle cell action potential (GO:0086005)2.53172233
174negative regulation of cell-matrix adhesion (GO:0001953)2.53116384
175estrogen metabolic process (GO:0008210)2.52341593
176response to dexamethasone (GO:0071548)2.51927154
177regulation of Rho protein signal transduction (GO:0035023)2.51509103
178membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.51113046
179fatty acid beta-oxidation (GO:0006635)2.49795058
180negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.48916763
181basement membrane organization (GO:0071711)2.48844464
182positive regulation of steroid metabolic process (GO:0045940)2.47744226
183cGMP-mediated signaling (GO:0019934)2.47526645
184adhesion of symbiont to host (GO:0044406)2.47500050
185regulation of plasminogen activation (GO:0010755)2.47303569
186atrioventricular valve morphogenesis (GO:0003181)2.46929952
187white fat cell differentiation (GO:0050872)2.45529634
188glucocorticoid biosynthetic process (GO:0006704)13.5220355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.77978570
2GATA1_22025678_ChIP-Seq_K562_Human4.91342423
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.84688261
4CLOCK_20551151_ChIP-Seq_293T_Human3.47087584
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54221954
6ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.32215846
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.23514972
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20620773
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.15217843
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.13827782
11TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.11337171
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.07766033
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06974502
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.00963093
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.95709576
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88812406
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86561368
18BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.82420498
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79328071
20RXR_22158963_ChIP-Seq_LIVER_Mouse1.78387286
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.75189078
22TBX20_22080862_ChIP-Seq_HEART_Mouse1.70218778
23TBX20_22328084_ChIP-Seq_HEART_Mouse1.70218778
24* CJUN_26792858_Chip-Seq_BT549_Human1.66776458
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.65219688
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.63772328
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61317538
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.53400675
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51846241
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51014585
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.47378006
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46445889
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42638911
34PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.41779679
35GBX2_23144817_ChIP-Seq_PC3_Human1.35338739
36SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34827067
37RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31806532
38ZNF263_19887448_ChIP-Seq_K562_Human1.30652928
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28230077
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27605716
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.27528709
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26169514
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24589971
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22930695
45AHR_22903824_ChIP-Seq_MCF-7_Human1.19531655
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19460573
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19452136
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19344614
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17502182
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13895944
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.11892834
52BCAT_22108803_ChIP-Seq_LS180_Human1.08281067
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.06842270
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06216336
55SOX2_20726797_ChIP-Seq_SW620_Human1.05908727
56SMAD3_21741376_ChIP-Seq_HESCs_Human1.05806671
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05697737
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03664964
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03452891
60DROSHA_22980978_ChIP-Seq_HELA_Human1.03168862
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03115948
62* SMAD4_21799915_ChIP-Seq_A2780_Human1.02566578
63JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02281418
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01844352
65ARNT_22903824_ChIP-Seq_MCF-7_Human0.99849618
66ELK3_25401928_ChIP-Seq_HUVEC_Human0.99757348
67SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99735864
68ISL1_27105846_Chip-Seq_CPCs_Mouse0.98714461
69FOXA2_19822575_ChIP-Seq_HepG2_Human0.98355342
70MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97233765
71EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97169070
72RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97169070
73EGR1_19032775_ChIP-ChIP_M12_Human0.96010530
74LXR_22292898_ChIP-Seq_THP-1_Human0.95191164
75AR_21572438_ChIP-Seq_LNCaP_Human0.95070657
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94959044
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93373428
78JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93372511
79NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93324283
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93324283
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93078327
82HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92265688
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92176160
84EZH2_22144423_ChIP-Seq_EOC_Human0.91831725
85NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91528298
86NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90612817
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90253507
88TP53_16413492_ChIP-PET_HCT116_Human0.90021339
89GF1_26923725_Chip-Seq_HPCs_Mouse0.90015788
90SMAD4_21741376_ChIP-Seq_HESCs_Human0.89684711
91CDX2_20551321_ChIP-Seq_CACO-2_Human0.89679830
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89601817
93WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89428130
94RUNX1_27514584_Chip-Seq_MCF-7_Human0.88793453
95KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88705123
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88325441
97PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88160792
98WT1_19549856_ChIP-ChIP_CCG9911_Human0.87096765
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86959829
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86886266
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85646570
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85005072
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84618137
104SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84073313
105YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83642442
106PIAS1_25552417_ChIP-Seq_VCAP_Human0.83625232
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83322725
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83253352
109EZH2_27304074_Chip-Seq_ESCs_Mouse0.83059173
110SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83039222
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82942271
112KDM2B_26808549_Chip-Seq_K562_Human0.81742833
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81589326
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81532029
115SMAD_19615063_ChIP-ChIP_OVARY_Human0.81347470
116RACK7_27058665_Chip-Seq_MCF-7_Human0.81260973
117RNF2_27304074_Chip-Seq_ESCs_Mouse0.80916850
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80853187
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.80779884
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80649432
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80614514
122GATA1_19941826_ChIP-Seq_K562_Human0.80255117
123BRD4_25478319_ChIP-Seq_HGPS_Human0.79124025
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78820002
125* VDR_24787735_ChIP-Seq_THP-1_Human0.78747942
126P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77605359
127TP53_18474530_ChIP-ChIP_U2OS_Human0.77409271
128CSB_26484114_Chip-Seq_FIBROBLAST_Human0.77275222
129* TP63_23658742_ChIP-Seq_EP156T_Human0.76538477
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.76348328
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75079525
132SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75079525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.18108856
2MP0005275_abnormal_skin_tensile5.62581527
3MP0005503_abnormal_tendon_morphology4.53561085
4MP0001958_emphysema3.95856162
5MP0005257_abnormal_intraocular_pressure3.36647663
6MP0005670_abnormal_white_adipose3.05900428
7MP0000639_abnormal_adrenal_gland3.02240193
8MP0002909_abnormal_adrenal_gland2.79636026
9MP0004272_abnormal_basement_membrane2.67506099
10MP0000751_myopathy2.54214903
11MP0010368_abnormal_lymphatic_system2.45989720
12MP0002837_dystrophic_cardiac_calcinosis2.43231371
13MP0003705_abnormal_hypodermis_morpholog2.41171402
14MP0004130_abnormal_muscle_cell2.38031489
15MP0005666_abnormal_adipose_tissue2.23679685
16MP0003724_increased_susceptibility_to2.12680311
17MP0009840_abnormal_foam_cell2.07448756
18MP0004185_abnormal_adipocyte_glucose1.94136441
19MP0002138_abnormal_hepatobiliary_system1.92291915
20MP0001879_abnormal_lymphatic_vessel1.91017042
21MP0002108_abnormal_muscle_morphology1.87042990
22MP0003191_abnormal_cellular_cholesterol1.84247790
23MP0000013_abnormal_adipose_tissue1.78048530
24MP0002295_abnormal_pulmonary_circulatio1.77574127
25MP0005375_adipose_tissue_phenotype1.76127888
26MP0002127_abnormal_cardiovascular_syste1.75105500
27MP0004782_abnormal_surfactant_physiolog1.74470753
28MP0003279_aneurysm1.67925117
29MP0003566_abnormal_cell_adhesion1.61600086
30MP0005410_abnormal_fertilization1.60933601
31MP0000343_altered_response_to1.59612223
32MP0006054_spinal_hemorrhage1.56577880
33MP0003045_fibrosis1.52080805
34MP0004085_abnormal_heartbeat1.52072403
35MP0002166_altered_tumor_susceptibility1.51778944
36MP0000750_abnormal_muscle_regeneration1.47240036
37MP0004036_abnormal_muscle_relaxation1.47121943
38MP0006138_congestive_heart_failure1.44506287
39MP0003137_abnormal_impulse_conducting1.42505081
40MP0002060_abnormal_skin_morphology1.41012999
41MP0002254_reproductive_system_inflammat1.40003350
42MP0005167_abnormal_blood-brain_barrier1.37388924
43MP0005388_respiratory_system_phenotype1.37212230
44MP0002133_abnormal_respiratory_system1.37212230
45MP0004084_abnormal_cardiac_muscle1.34553674
46MP0003828_pulmonary_edema1.31540297
47MP0000003_abnormal_adipose_tissue1.25697354
48MP0009780_abnormal_chondrocyte_physiolo1.24198481
49MP0010329_abnormal_lipoprotein_level1.22463065
50MP0003300_gastrointestinal_ulcer1.19911828
51MP0005508_abnormal_skeleton_morphology1.17958176
52MP0002269_muscular_atrophy1.17601917
53MP0002971_abnormal_brown_adipose1.16098440
54MP0010386_abnormal_urinary_bladder1.15136722
55MP0001756_abnormal_urination1.14266881
56MP0004087_abnormal_muscle_fiber1.13047602
57MP0008004_abnormal_stomach_pH1.12635910
58MP0005330_cardiomyopathy1.10728594
59MP0003303_peritoneal_inflammation1.10657992
60MP0005164_abnormal_response_to1.10222532
61MP0005385_cardiovascular_system_phenoty1.10133259
62MP0001544_abnormal_cardiovascular_syste1.10133259
63MP0003075_altered_response_to1.05537126
64MP0002168_other_aberrant_phenotype1.03985424
65MP0001661_extended_life_span1.03528392
66MP0001765_abnormal_ion_homeostasis1.01511198
67MP0003195_calcinosis1.00423664
68MP0005620_abnormal_muscle_contractility1.00178650
69MP0000249_abnormal_blood_vessel0.99742188
70MP0002006_tumorigenesis0.99383792
71MP0005023_abnormal_wound_healing0.97758450
72MP0003950_abnormal_plasma_membrane0.97242587
73MP0009115_abnormal_fat_cell0.96044095
74MP0005595_abnormal_vascular_smooth0.94985061
75MP0002139_abnormal_hepatobiliary_system0.93489015
76MP0000767_abnormal_smooth_muscle0.92954887
77MP0005369_muscle_phenotype0.91999312
78MP0005334_abnormal_fat_pad0.91502481
79MP0002118_abnormal_lipid_homeostasis0.91340054
80MP0005332_abnormal_amino_acid0.91154719
81MP0008875_abnormal_xenobiotic_pharmacok0.91153271
82MP0001984_abnormal_olfaction0.90722901
83MP0005165_increased_susceptibility_to0.90140637
84MP0000749_muscle_degeneration0.89964791
85MP0002896_abnormal_bone_mineralization0.88487080
86MP0003646_muscle_fatigue0.88129088
87MP0001533_abnormal_skeleton_physiology0.86074775
88MP0000230_abnormal_systemic_arterial0.84898206
89MP0005636_abnormal_mineral_homeostasis0.82802870
90MP0009384_cardiac_valve_regurgitation0.82068284
91MP0001177_atelectasis0.81985427
92MP0003690_abnormal_glial_cell0.80097873
93MP0004019_abnormal_vitamin_homeostasis0.79922348
94MP0004215_abnormal_myocardial_fiber0.78988760
95MP0005365_abnormal_bile_salt0.77965483
96MP0008775_abnormal_heart_ventricle0.77801361
97MP0005360_urolithiasis0.77586156
98MP0002106_abnormal_muscle_physiology0.76289756
99MP0004883_abnormal_blood_vessel0.75893226
100MP0010630_abnormal_cardiac_muscle0.74829370
101MP0000759_abnormal_skeletal_muscle0.74802347
102MP0005390_skeleton_phenotype0.74414598
103MP0000266_abnormal_heart_morphology0.73910081
104MP0002972_abnormal_cardiac_muscle0.72518500
105MP0003329_amyloid_beta_deposits0.71928305
106MP0000462_abnormal_digestive_system0.71837553
107MP0004484_altered_response_of0.71658313
108MP0003252_abnormal_bile_duct0.71434168
109MP0002128_abnormal_blood_circulation0.71419417
110MP0001542_abnormal_bone_strength0.70926776
111MP0000747_muscle_weakness0.70590389
112MP0002933_joint_inflammation0.70519166
113MP0009643_abnormal_urine_homeostasis0.69804654
114MP0003941_abnormal_skin_development0.69572042
115MP0003091_abnormal_cell_migration0.68503681
116MP0005058_abnormal_lysosome_morphology0.66944387
117MP0000534_abnormal_ureter_morphology0.65868996
118MP0002796_impaired_skin_barrier0.65601938
119MP0008995_early_reproductive_senescence0.65325656
120MP0004510_myositis0.65090179
121MP0000604_amyloidosis0.63970047
122MP0001614_abnormal_blood_vessel0.63775635
123MP0004043_abnormal_pH_regulation0.63685550
124MP0003567_abnormal_fetal_cardiomyocyte0.63157216
125MP0002998_abnormal_bone_remodeling0.62966937
126MP0005623_abnormal_meninges_morphology0.62730073
127MP0002136_abnormal_kidney_physiology0.62728582
128MP0001175_abnormal_lung_morphology0.62673818

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)6.84814635
2Hyperaldosteronism (HP:0000859)6.25843130
3Renal salt wasting (HP:0000127)6.22456432
4* Abnormality of complement system (HP:0005339)5.15327987
5Hypokalemic alkalosis (HP:0001949)5.13460134
6Glomerulonephritis (HP:0000099)5.12510096
7Increased connective tissue (HP:0009025)5.02048857
8Enlarged penis (HP:0000040)4.96490645
9Ankle contracture (HP:0006466)4.74575649
10Broad metatarsal (HP:0001783)4.74259337
11Aortic aneurysm (HP:0004942)4.72838290
12Abnormality of renin-angiotensin system (HP:0000847)4.54432870
13Protrusio acetabuli (HP:0003179)4.53170017
14Muscle fiber splitting (HP:0003555)4.40806541
15Aortic dissection (HP:0002647)4.32517884
16Type 1 muscle fiber predominance (HP:0003803)4.14806238
17Abnormality of the nasal mucosa (HP:0000433)4.00777217
18Cerebral aneurysm (HP:0004944)3.83169299
19Facial diplegia (HP:0001349)3.78902596
20Atrial fibrillation (HP:0005110)3.75688675
21Adrenal overactivity (HP:0002717)3.72974083
22Papilledema (HP:0001085)3.68897578
23Hematochezia (HP:0002573)3.68660328
24Polycythemia (HP:0001901)3.66582851
25Nephritis (HP:0000123)3.65118822
26Syncope (HP:0001279)3.63863285
27Hypokalemia (HP:0002900)3.57148903
28Rectal prolapse (HP:0002035)3.46253746
29Facial shape deformation (HP:0011334)3.45210872
30Potter facies (HP:0002009)3.45210872
31Spinal rigidity (HP:0003306)3.35329441
32Primary atrial arrhythmia (HP:0001692)3.33694239
33Flat cornea (HP:0007720)3.29032824
34Premature rupture of membranes (HP:0001788)3.28369430
35Hypoplasia of the uterus (HP:0000013)3.27182362
36Increased variability in muscle fiber diameter (HP:0003557)3.26248012
37Follicular hyperkeratosis (HP:0007502)3.22749417
38Supraventricular tachycardia (HP:0004755)3.15590810
39Ventricular fibrillation (HP:0001663)3.14890534
40Supraventricular arrhythmia (HP:0005115)3.13218833
41Prolonged QT interval (HP:0001657)3.10580675
42Amyloidosis (HP:0011034)3.06451004
43Chronic bronchitis (HP:0004469)3.04312064
44Lymphangioma (HP:0100764)3.02760676
45Hyporeflexia of lower limbs (HP:0002600)3.00573696
46Acanthosis nigricans (HP:0000956)3.00084343
47Interstitial pulmonary disease (HP:0006530)2.98349182
48Pulmonary artery stenosis (HP:0004415)2.96259320
49Wrist flexion contracture (HP:0001239)2.92866416
50Spontaneous hematomas (HP:0007420)2.90845478
51Soft skin (HP:0000977)2.89296638
52Abnormality of skeletal muscle fiber size (HP:0012084)2.87193335
53Oligomenorrhea (HP:0000876)2.85944927
54Striae distensae (HP:0001065)2.85019103
55Growth hormone excess (HP:0000845)2.84347379
56Atrioventricular block (HP:0001678)2.82468586
57Round ear (HP:0100830)2.81285735
58Increased circulating renin level (HP:0000848)2.79690747
59Alkalosis (HP:0001948)2.79046017
60Mitral valve prolapse (HP:0001634)2.78439149
61Aneurysm (HP:0002617)2.75566006
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.74023895
63Osteolytic defects of the hand bones (HP:0009699)2.74023895
64Right ventricular cardiomyopathy (HP:0011663)2.72994936
65Systemic lupus erythematosus (HP:0002725)2.68052230
66Abnormality of potassium homeostasis (HP:0011042)2.66584106
67Bundle branch block (HP:0011710)2.65779451
68Slender build (HP:0001533)2.62773182
69Metabolic alkalosis (HP:0200114)2.59238743
70Mildly elevated creatine phosphokinase (HP:0008180)2.51354708
71Shallow orbits (HP:0000586)2.49529204
72Persistence of primary teeth (HP:0006335)2.47042598
73Abnormal atrioventricular conduction (HP:0005150)2.44272285
74Camptodactyly of toe (HP:0001836)2.44161669
75Heart block (HP:0012722)2.43924279
76Tubulointerstitial fibrosis (HP:0005576)2.43517541
77* Complement deficiency (HP:0004431)2.39612395
78Hyperkalemia (HP:0002153)2.37682538
79Mesangial abnormality (HP:0001966)2.37524498
80Sudden death (HP:0001699)2.37335041
81Testicular neoplasm (HP:0010788)2.36857820
82Broad ribs (HP:0000885)2.36714377
83Ventricular arrhythmia (HP:0004308)2.36378147
84Bladder diverticulum (HP:0000015)2.35431117
85Long toe (HP:0010511)2.34413611
86Patent foramen ovale (HP:0001655)2.34217558
87Metaphyseal dysplasia (HP:0100255)2.32443507
88Bronchomalacia (HP:0002780)2.31336297
89Abnormality of the fingertips (HP:0001211)2.30771199
90Dilatation of the ascending aorta (HP:0005111)2.29592005
91Congenital sensorineural hearing impairment (HP:0008527)2.28172522
92Esophageal varix (HP:0002040)2.26534230
93Neonatal onset (HP:0003623)2.26432932
94Nasal polyposis (HP:0100582)2.24340862
95Hyperactive renin-angiotensin system (HP:0000841)2.24195390
96Abnormality of monocarboxylic acid metabolism (HP:0010996)2.23954554
97Difficulty running (HP:0009046)2.19589518
98Increased density of long bones (HP:0006392)2.19213669
99Vascular tortuosity (HP:0004948)2.18164520
100Accelerated skeletal maturation (HP:0005616)2.16667670
101Cervical subluxation (HP:0003308)2.15730007
102Abnormal EKG (HP:0003115)2.13666388
103Aplasia/hypoplasia of the uterus (HP:0008684)2.12208540
104Hemorrhage of the eye (HP:0011885)2.11550253
105Joint hemorrhage (HP:0005261)2.11409431
106Visceral angiomatosis (HP:0100761)2.11188448
107Exercise-induced myalgia (HP:0003738)2.10179443
108Bilateral sensorineural hearing impairment (HP:0008619)2.08493656
109Aortic regurgitation (HP:0001659)2.07278103
110Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.07229754
111Bulbar palsy (HP:0001283)2.05570458
112Skin nodule (HP:0200036)2.02944615
113Venous abnormality (HP:0002624)2.02120632
114Deep venous thrombosis (HP:0002625)2.01196890
115Proximal amyotrophy (HP:0007126)1.99908666
116Cerebral hemorrhage (HP:0001342)1.99409760
117Atrophic scars (HP:0001075)1.98378568
118Hypoplasia of the iris (HP:0007676)1.97869854
119Limited hip movement (HP:0008800)1.97813270
120Lipoatrophy (HP:0100578)1.97137539
121Xanthomatosis (HP:0000991)1.96736132
122Hypertriglyceridemia (HP:0002155)1.96663338
123Hyperextensible skin (HP:0000974)1.94646260
124Abnormality of chloride homeostasis (HP:0011422)1.93689764
125Venous insufficiency (HP:0005293)1.93670817
126Overgrowth (HP:0001548)1.93247238
127Myoglobinuria (HP:0002913)1.92935469
128Gastrointestinal dysmotility (HP:0002579)1.90472785
129Hemangiomatosis (HP:0007461)1.89345555
130Abnormal urine output (HP:0012590)1.88545859
131Abnormality of the axillary hair (HP:0100134)1.88068703
132Abnormality of secondary sexual hair (HP:0009888)1.88068703
133Stroke (HP:0001297)1.87348832
134Male pseudohermaphroditism (HP:0000037)1.86379687
135Disproportionate tall stature (HP:0001519)1.86264789
136Wormian bones (HP:0002645)1.86094579
137Subcapsular cataract (HP:0000523)1.86025545
138Ventricular tachycardia (HP:0004756)1.85276427
139Joint laxity (HP:0001388)1.84202946
140Conjunctival telangiectasia (HP:0000524)1.81039761
141Bronchitis (HP:0012387)1.80838932
142Abnormality of the vasculature of the conjunctiva (HP:0008054)1.80764590
143Polyuria (HP:0000103)1.79751395
144Hip contracture (HP:0003273)1.78062015
145Mitral stenosis (HP:0001718)1.76913170
146Gonadal dysgenesis (HP:0000133)1.75958689
147Flexion contracture of toe (HP:0005830)1.74455577
148Joint contractures involving the joints of the feet (HP:0100492)1.74455577
149Joint stiffness (HP:0001387)1.73827123
150Hypercortisolism (HP:0001578)1.73661949
151Cardiovascular calcification (HP:0011915)1.73173006
152Clitoromegaly (HP:0000057)1.72544966
153Abnormal cartilage morphology (HP:0002763)1.72261164
154Aplasia of the musculature (HP:0100854)1.71748532
155Dilated cardiomyopathy (HP:0001644)1.71593234
156Asymmetric septal hypertrophy (HP:0001670)1.70967092
157Abnormality of renal excretion (HP:0011036)1.70548928
158Ulnar bowing (HP:0003031)1.70411614
159Arterial tortuosity (HP:0005116)1.70236399
160Abnormality of the calf musculature (HP:0001430)1.69634314
161Short hallux (HP:0010109)1.69416147
162Abnormal sex determination (HP:0012244)1.67904687
163Sex reversal (HP:0012245)1.67904687
164Pulmonary hypertension (HP:0002092)1.66637340
165Distal lower limb muscle weakness (HP:0009053)1.64619968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.30057035
2MYLK4.15475690
3TRIB33.43951687
4TTN3.17665114
5TGFBR23.06636713
6PDK32.90174599
7PDK42.90174599
8RIPK12.81304850
9ERN12.70861133
10WNK32.56115511
11CAMK1D2.42869663
12LMTK22.34958134
13SIK12.12274057
14DDR22.09473508
15PDGFRA2.07640263
16PDK22.03370055
17DMPK1.99767746
18CAMK1G1.97273690
19NLK1.83300433
20EPHB21.68433846
21PRKD31.65177214
22FGFR21.63624861
23FGFR41.62689515
24EPHB11.62380165
25LATS11.60927943
26MELK1.60640852
27FER1.53273880
28CSK1.48961014
29OXSR11.48056414
30MST1R1.47420180
31MAP3K51.46434607
32SGK21.46052766
33FRK1.38216147
34STK38L1.32389838
35PTK2B1.30632972
36PAK21.27242410
37TRPM71.22574293
38PHKG11.18738795
39PHKG21.18738795
40BCKDK1.18152173
41MAP3K31.17913180
42SGK4941.17125095
43SGK2231.17125095
44TESK11.16973625
45FGFR31.16540533
46EPHA31.12886482
47SGK31.12854231
48LRRK21.09075612
49PDGFRB1.04329938
50PRKCH0.99733087
51PIK3CG0.97097302
52MAP3K60.95879797
53MAP2K30.92500910
54GSK3A0.90660284
55MET0.90447843
56INSRR0.88213936
57AKT30.87940470
58PTK60.86753119
59DAPK20.85803460
60JAK10.85142361
61MAPK70.83315741
62ICK0.79215531
63OBSCN0.76611486
64NTRK10.76089563
65ILK0.75706006
66PRPF4B0.74965191
67MAPKAPK30.74834843
68PRKD10.74452505
69TGFBR10.73481865
70JAK20.73062887
71PKN20.72862617
72MAPK150.72584571
73PIK3CA0.71358494
74MAP3K20.70937667
75PRKAA20.69308579
76KIT0.67503602
77CAMK40.66677420
78PAK40.65331463
79PDPK10.63182816
80IRAK10.62496152
81RPS6KA20.61317394
82RET0.60445595
83TAOK30.58731038
84MAP3K70.56924902
85PRKCE0.56252892
86ROCK20.55336788
87ROCK10.55040486
88KDR0.52255772
89MUSK0.50737607
90MAP2K10.50350310
91STK390.50348448
92WNK40.50326566
93RPS6KC10.48516012
94RPS6KL10.48516012
95GRK10.47706801
96MTOR0.47243488
97MAPK30.46670417
98NTRK30.46519356
99STK380.45664783
100STK30.45353395
101PTK20.45343511
102AKT20.44808196
103PRKD20.44679874
104SGK10.44626631
105CAMK2D0.43709559
106WNK10.43132474
107PRKACA0.42655487
108DAPK30.41977520
109HIPK20.41926866
110EEF2K0.41858196
111LATS20.40731458
112TYK20.39961700
113PDK10.39473858
114MARK20.39423436
115NEK90.39313938
116RPS6KA60.39290254
117SRC0.38204999
118CDC42BPA0.36618288
119STK100.36238491
120PRKAA10.35735129
121MAPK120.34317105
122EGFR0.33931779
123PINK10.33909625
124MAPK40.32086291
125PRKG10.31829493
126BMX0.31686342
127CDK60.31109137
128PAK30.30789952
129PRKACG0.30557246
130TYRO30.30426885
131ZAP700.28726847
132INSR0.28206167
133IGF1R0.27338953
134CAMK10.25239030

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid hormone biosynthesis_Homo sapiens_hsa001403.53969608
2ECM-receptor interaction_Homo sapiens_hsa045123.39220825
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.72821528
4PPAR signaling pathway_Homo sapiens_hsa033202.68710381
5Fatty acid biosynthesis_Homo sapiens_hsa000612.56992577
6Propanoate metabolism_Homo sapiens_hsa006402.45386657
7Fatty acid degradation_Homo sapiens_hsa000712.26340002
8Fatty acid metabolism_Homo sapiens_hsa012122.16004675
9Protein digestion and absorption_Homo sapiens_hsa049742.10650635
10Focal adhesion_Homo sapiens_hsa045102.07625561
11Nitrogen metabolism_Homo sapiens_hsa009101.96376675
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82524146
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81633864
14Caffeine metabolism_Homo sapiens_hsa002321.77247739
15Adipocytokine signaling pathway_Homo sapiens_hsa049201.68160151
16Histidine metabolism_Homo sapiens_hsa003401.67255898
17Glycerolipid metabolism_Homo sapiens_hsa005611.56477907
18Malaria_Homo sapiens_hsa051441.46522990
19Renin secretion_Homo sapiens_hsa049241.45467584
20ABC transporters_Homo sapiens_hsa020101.42941169
21Retinol metabolism_Homo sapiens_hsa008301.40434925
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38734522
23Pyruvate metabolism_Homo sapiens_hsa006201.38450058
24* Complement and coagulation cascades_Homo sapiens_hsa046101.37145862
25Tryptophan metabolism_Homo sapiens_hsa003801.35568295
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33698584
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33286817
28Staphylococcus aureus infection_Homo sapiens_hsa051501.32378025
29Dilated cardiomyopathy_Homo sapiens_hsa054141.30867898
30Insulin resistance_Homo sapiens_hsa049311.28762241
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23441735
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.20084871
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19576933
34Amoebiasis_Homo sapiens_hsa051461.16892072
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13076273
36AMPK signaling pathway_Homo sapiens_hsa041521.09504955
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05304824
38Fat digestion and absorption_Homo sapiens_hsa049750.96742665
39* Prion diseases_Homo sapiens_hsa050200.95935509
40beta-Alanine metabolism_Homo sapiens_hsa004100.94277089
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89686598
42Carbon metabolism_Homo sapiens_hsa012000.87941096
43Glucagon signaling pathway_Homo sapiens_hsa049220.86548860
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86240091
45Renin-angiotensin system_Homo sapiens_hsa046140.85707513
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83144764
47Circadian rhythm_Homo sapiens_hsa047100.81236317
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81144693
49Adherens junction_Homo sapiens_hsa045200.80923133
50Bile secretion_Homo sapiens_hsa049760.80497826
51Platelet activation_Homo sapiens_hsa046110.80429739
52Selenocompound metabolism_Homo sapiens_hsa004500.78616226
53Insulin signaling pathway_Homo sapiens_hsa049100.77856302
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.77820711
55PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76462117
56Proteoglycans in cancer_Homo sapiens_hsa052050.76316108
57Linoleic acid metabolism_Homo sapiens_hsa005910.75482034
58Toxoplasmosis_Homo sapiens_hsa051450.74900815
59Small cell lung cancer_Homo sapiens_hsa052220.74260391
60Phenylalanine metabolism_Homo sapiens_hsa003600.73421630
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73417602
62Dorso-ventral axis formation_Homo sapiens_hsa043200.72446327
63Vitamin B6 metabolism_Homo sapiens_hsa007500.72059891
64Pancreatic secretion_Homo sapiens_hsa049720.70731731
65Thyroid hormone synthesis_Homo sapiens_hsa049180.69957918
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68279088
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67785348
68Type II diabetes mellitus_Homo sapiens_hsa049300.67108264
69Pertussis_Homo sapiens_hsa051330.65965499
70Gastric acid secretion_Homo sapiens_hsa049710.65687031
71Viral myocarditis_Homo sapiens_hsa054160.64632744
72Tight junction_Homo sapiens_hsa045300.64581800
73Chemical carcinogenesis_Homo sapiens_hsa052040.63995741
74Tyrosine metabolism_Homo sapiens_hsa003500.63934149
75Arginine biosynthesis_Homo sapiens_hsa002200.62719295
76Prolactin signaling pathway_Homo sapiens_hsa049170.61325920
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61248662
78Ovarian steroidogenesis_Homo sapiens_hsa049130.60780534
79Estrogen signaling pathway_Homo sapiens_hsa049150.60689099
80Peroxisome_Homo sapiens_hsa041460.60215925
81Lysosome_Homo sapiens_hsa041420.59921621
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.59823832
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.58451901
84Sulfur metabolism_Homo sapiens_hsa009200.57851146
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57577233
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55746685
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.54230163
88Salivary secretion_Homo sapiens_hsa049700.54153952
89TGF-beta signaling pathway_Homo sapiens_hsa043500.52911971
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52803465
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.52353276
92Gap junction_Homo sapiens_hsa045400.52258675
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52155214
94Steroid biosynthesis_Homo sapiens_hsa001000.51207549
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50673447
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49666775
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49535316
98Phagosome_Homo sapiens_hsa041450.49527609
99Vitamin digestion and absorption_Homo sapiens_hsa049770.49137962
100cAMP signaling pathway_Homo sapiens_hsa040240.47481916
101Starch and sucrose metabolism_Homo sapiens_hsa005000.46423208
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.46285867
103VEGF signaling pathway_Homo sapiens_hsa043700.44060149
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43271911
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43191549
106Choline metabolism in cancer_Homo sapiens_hsa052310.41585798
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40997911
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40725349
109Butanoate metabolism_Homo sapiens_hsa006500.40561732
110Lysine degradation_Homo sapiens_hsa003100.40550716
111Arachidonic acid metabolism_Homo sapiens_hsa005900.40260671
112Cardiac muscle contraction_Homo sapiens_hsa042600.40044834
113Other glycan degradation_Homo sapiens_hsa005110.39731562
114Oxytocin signaling pathway_Homo sapiens_hsa049210.39514908
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38809383
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38539148
117Arginine and proline metabolism_Homo sapiens_hsa003300.37607474
118Calcium signaling pathway_Homo sapiens_hsa040200.32705382
119Rap1 signaling pathway_Homo sapiens_hsa040150.32602417
120Endocytosis_Homo sapiens_hsa041440.31928504
121Bladder cancer_Homo sapiens_hsa052190.31311644
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31264828
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31148565
124Mineral absorption_Homo sapiens_hsa049780.29846164
125Circadian entrainment_Homo sapiens_hsa047130.28364234
126HIF-1 signaling pathway_Homo sapiens_hsa040660.27932802

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