ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	5.57984509
2	regulation of meiosis I (GO:0060631)	4.61424229
3	mannosylation (GO:0097502)	4.40220221
4	DNA double-strand break processing (GO:0000729)	4.22303190
5	water-soluble vitamin biosynthetic process (GO:0042364)	4.11547213
6	resolution of meiotic recombination intermediates (GO:0000712)	3.81173324
7	ubiquinone biosynthetic process (GO:0006744)	3.80800799
8	adenosine metabolic process (GO:0046085)	3.71867548
9	xenobiotic catabolic process (GO:0042178)	3.71140447
10	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.67921512
11	negative regulation of response to food (GO:0032096)	3.66425743
12	negative regulation of appetite (GO:0032099)	3.66425743
13	piRNA metabolic process (GO:0034587)	3.63858859
14	regulation of response to food (GO:0032095)	3.63273857
15	negative regulation of thymocyte apoptotic process (GO:0070244)	3.57533227
16	replication fork processing (GO:0031297)	3.55225317
17	proteasome assembly (GO:0043248)	3.54543661
18	centriole assembly (GO:0098534)	3.49456951
19	toxin transport (GO:1901998)	3.48391836
20	protein polyglutamylation (GO:0018095)	3.47208810
21	ubiquinone metabolic process (GO:0006743)	3.43569406
22	centriole replication (GO:0007099)	3.33822446
23	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.29813317
24	negative regulation of heart rate (GO:0010459)	3.28791102
25	response to nitrosative stress (GO:0051409)	3.23488967
26	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.21910907
27	cellular ketone body metabolic process (GO:0046950)	3.21556053
28	inositol phosphate catabolic process (GO:0071545)	3.19304230
29	regulation of protein glycosylation (GO:0060049)	3.17341351
30	amino acid salvage (GO:0043102)	3.17004533
31	L-methionine salvage (GO:0071267)	3.17004533
32	L-methionine biosynthetic process (GO:0071265)	3.17004533
33	respiratory chain complex IV assembly (GO:0008535)	3.15669750
34	male meiosis I (GO:0007141)	3.14607812
35	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.12773796
36	inositol phosphate dephosphorylation (GO:0046855)	3.12773796
37	ketone body metabolic process (GO:1902224)	3.12547033
38	protein complex biogenesis (GO:0070271)	3.11715272
39	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.06492661
40	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.06288369
41	protein deneddylation (GO:0000338)	2.96515963
42	negative regulation of neurological system process (GO:0031645)	2.94308303
43	protein K11-linked ubiquitination (GO:0070979)	2.91744382
44	regulation of cilium movement (GO:0003352)	2.91216715
45	protein-cofactor linkage (GO:0018065)	2.91060209
46	aggressive behavior (GO:0002118)	2.85894425
47	positive regulation of digestive system process (GO:0060456)	2.85346355
48	cytochrome complex assembly (GO:0017004)	2.84761552
49	labyrinthine layer development (GO:0060711)	2.82333072
50	quinone biosynthetic process (GO:1901663)	2.81357835
51	platelet dense granule organization (GO:0060155)	2.81262483
52	NADH dehydrogenase complex assembly (GO:0010257)	2.79345713
53	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.79345713
54	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.79345713
55	negative regulation of membrane potential (GO:0045837)	2.78336742
56	fatty acid elongation (GO:0030497)	2.77741505
57	protein K6-linked ubiquitination (GO:0085020)	2.74127092
58	regulation of transmission of nerve impulse (GO:0051969)	2.73477309
59	axoneme assembly (GO:0035082)	2.73217774
60	acrosome reaction (GO:0007340)	2.72054825
61	regulation of feeding behavior (GO:0060259)	2.71631928
62	DNA methylation involved in gamete generation (GO:0043046)	2.71512440
63	ATP hydrolysis coupled proton transport (GO:0015991)	2.66137661
64	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.66137661
65	organelle membrane fusion (GO:0090174)	2.63409210
66	regulation of female gonad development (GO:2000194)	2.62382522
67	microtubule depolymerization (GO:0007019)	2.60296804
68	methionine biosynthetic process (GO:0009086)	2.59279165
69	epithelial cilium movement (GO:0003351)	2.58940463
70	behavioral response to nicotine (GO:0035095)	2.58765810
71	keratinocyte development (GO:0003334)	2.58452333
72	mitochondrial respiratory chain complex assembly (GO:0033108)	2.57577466
73	endosome to pigment granule transport (GO:0043485)	2.56507579
74	endosome to melanosome transport (GO:0035646)	2.56507579
75	meiosis I (GO:0007127)	2.56409399
76	C-terminal protein lipidation (GO:0006501)	2.56179388
77	detection of light stimulus involved in visual perception (GO:0050908)	2.55059623
78	detection of light stimulus involved in sensory perception (GO:0050962)	2.55059623
79	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.53310044
80	C-terminal protein amino acid modification (GO:0018410)	2.51045354
81	male meiosis (GO:0007140)	2.48707663
82	regulation of appetite (GO:0032098)	2.48555193
83	cornea development in camera-type eye (GO:0061303)	2.48444675
84	cullin deneddylation (GO:0010388)	2.48085564
85	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.47501155
86	protein K48-linked ubiquitination (GO:0070936)	2.46506096
87	nucleotide transmembrane transport (GO:1901679)	2.46195165
88	regulation of skeletal muscle contraction (GO:0014819)	2.46004104
89	methionine metabolic process (GO:0006555)	2.44849391
90	intraciliary transport (GO:0042073)	2.44281443
91	rRNA modification (GO:0000154)	2.43837702
92	negative regulation of DNA recombination (GO:0045910)	2.43566353
93	brain morphogenesis (GO:0048854)	2.41703328
94	motile cilium assembly (GO:0044458)	2.40897457
95	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.40554154
96	isotype switching (GO:0045190)	2.40554154
97	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.40554154
98	regulation of acrosome reaction (GO:0060046)	2.40349993
99	dopamine transport (GO:0015872)	2.38083677
100	coenzyme catabolic process (GO:0009109)	2.37550584

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.97843783
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.41947181
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.21229795
4	* POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.20010365
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.04715071
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.79330911
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44446796
8	VDR_22108803_ChIP-Seq_LS180_Human	2.41243750
9	EWS_26573619_Chip-Seq_HEK293_Human	2.40540740
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.37255790
11	FUS_26573619_Chip-Seq_HEK293_Human	2.34015694
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.31100250
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30318002
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22740784
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.13695105
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.10595556
17	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.06468277
18	P300_19829295_ChIP-Seq_ESCs_Human	2.04697932
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.96109761
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.95471730
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.74469926
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.74469926
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.73964751
24	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.72846555
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.71202650
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68539269
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.68144177
28	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.63631692
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62101234
30	HTT_18923047_ChIP-ChIP_STHdh_Human	1.60281384
31	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.57948561
32	NANOG_19829295_ChIP-Seq_ESCs_Human	1.57489306
33	SOX2_19829295_ChIP-Seq_ESCs_Human	1.57489306
34	EZH2_22144423_ChIP-Seq_EOC_Human	1.57418855
35	* AR_25329375_ChIP-Seq_VCAP_Human	1.57391413
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.57198364
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.56983323
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56132488
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.55292600
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.51420115
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50577973
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.46193042
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43679069
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43679069
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.40191466
46	STAT3_23295773_ChIP-Seq_U87_Human	1.37092464
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37044679
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.35905673
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.35514633
50	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.33608586
51	VDR_23849224_ChIP-Seq_CD4+_Human	1.33229996
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.32604947
53	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31868323
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.31442259
55	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.28484938
56	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.28126107
57	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.27747490
58	TCF4_23295773_ChIP-Seq_U87_Human	1.25152728
59	* JUN_21703547_ChIP-Seq_K562_Human	1.23714516
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22135976
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21878700
62	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21752616
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20117855
64	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.19887423
65	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16492253
66	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.15517949
67	AR_20517297_ChIP-Seq_VCAP_Human	1.14422688
68	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.13849661
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13099594
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11425164
71	* TCF4_22108803_ChIP-Seq_LS180_Human	1.11046749
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10796519
73	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09604353
74	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.09542361
75	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.09334928
76	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.09127382
77	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09101429
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08449798
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07559346
80	* SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06910985
81	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.06517116
82	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.06272834
83	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.06225854
84	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04189878
85	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.03507212
86	FOXP3_21729870_ChIP-Seq_TREG_Human	1.03325900
87	IRF1_19129219_ChIP-ChIP_H3396_Human	1.03255134
88	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01604478
89	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01134216
90	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.99940175
91	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98686127
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97876838
93	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97313620
94	* SALL4_22934838_ChIP-ChIP_CD34+_Human	0.96235971
95	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.95658312
96	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.94385909
97	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.93294566
98	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.93226799
99	PHF8_20622853_ChIP-Seq_HELA_Human	0.92658798
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.92433695

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.85388920
2	MP0005646_abnormal_pituitary_gland	3.46906162
3	MP0003123_paternal_imprinting	3.41793386
4	MP0003121_genomic_imprinting	2.92844360
5	MP0009697_abnormal_copulation	2.85301838
6	MP0003646_muscle_fatigue	2.73595470
7	MP0003122_maternal_imprinting	2.64889468
8	MP0005083_abnormal_biliary_tract	2.53279803
9	MP0001984_abnormal_olfaction	2.49275085
10	MP0003195_calcinosis	2.47678056
11	MP0003787_abnormal_imprinting	2.39466968
12	MP0002837_dystrophic_cardiac_calcinosis	2.39233955
13	MP0008058_abnormal_DNA_repair	2.30508765
14	MP0003718_maternal_effect	2.25369802
15	MP0005084_abnormal_gallbladder_morpholo	2.08134016
16	MP0005551_abnormal_eye_electrophysiolog	1.95625095
17	MP0003950_abnormal_plasma_membrane	1.93019015
18	MP0009780_abnormal_chondrocyte_physiolo	1.84105877
19	MP0009046_muscle_twitch	1.83705215
20	MP0000569_abnormal_digit_pigmentation	1.81295067
21	MP0006072_abnormal_retinal_apoptosis	1.74959710
22	MP0008789_abnormal_olfactory_epithelium	1.68132166
23	MP0003786_premature_aging	1.68130652
24	MP0004142_abnormal_muscle_tone	1.55246262
25	MP0001529_abnormal_vocalization	1.54803606
26	MP0005645_abnormal_hypothalamus_physiol	1.54736141
27	MP0004484_altered_response_of	1.52692030
28	MP0006292_abnormal_olfactory_placode	1.50790177
29	MP0002102_abnormal_ear_morphology	1.47416695
30	MP0002736_abnormal_nociception_after	1.45380681
31	MP0005167_abnormal_blood-brain_barrier	1.41028038
32	MP0000015_abnormal_ear_pigmentation	1.39918159
33	MP0010368_abnormal_lymphatic_system	1.34938004
34	MP0002090_abnormal_vision	1.34574498
35	MP0000372_irregular_coat_pigmentation	1.34408791
36	MP0002272_abnormal_nervous_system	1.34388294
37	MP0002234_abnormal_pharynx_morphology	1.29099768
38	MP0005187_abnormal_penis_morphology	1.28432919
39	MP0001968_abnormal_touch/_nociception	1.28317659
40	MP0000631_abnormal_neuroendocrine_gland	1.26526749
41	MP0006276_abnormal_autonomic_nervous	1.25719773
42	MP0003186_abnormal_redox_activity	1.24357153
43	MP0005410_abnormal_fertilization	1.19150724
44	MP0005464_abnormal_platelet_physiology	1.17628971
45	MP0010386_abnormal_urinary_bladder	1.16401456
46	MP0004043_abnormal_pH_regulation	1.15587584
47	MP0006035_abnormal_mitochondrial_morpho	1.14996179
48	MP0005647_abnormal_sex_gland	1.14506602
49	MP0008872_abnormal_physiological_respon	1.14247369
50	MP0006036_abnormal_mitochondrial_physio	1.11602438
51	MP0005253_abnormal_eye_physiology	1.11575752
52	MP0004134_abnormal_chest_morphology	1.10876859
53	MP0005367_renal/urinary_system_phenotyp	1.10594854
54	MP0000516_abnormal_urinary_system	1.10594854
55	MP0004215_abnormal_myocardial_fiber	1.10355973
56	MP0001661_extended_life_span	1.09654114
57	MP0003880_abnormal_central_pattern	1.08287440
58	MP0002909_abnormal_adrenal_gland	1.07524832
59	MP0001929_abnormal_gametogenesis	1.05112987
60	MP0002160_abnormal_reproductive_system	1.04648843
61	MP0009745_abnormal_behavioral_response	1.02230289
62	MP0000613_abnormal_salivary_gland	1.00931491
63	MP0005499_abnormal_olfactory_system	1.00638428
64	MP0005394_taste/olfaction_phenotype	1.00638428
65	MP0002210_abnormal_sex_determination	1.00554239
66	MP0002638_abnormal_pupillary_reflex	0.97108972
67	MP0005174_abnormal_tail_pigmentation	0.93659843
68	MP0000639_abnormal_adrenal_gland	0.93123897
69	MP0000427_abnormal_hair_cycle	0.93021765
70	MP0000230_abnormal_systemic_arterial	0.92685299
71	MP0002132_abnormal_respiratory_system	0.92435979
72	MP0005332_abnormal_amino_acid	0.92270851
73	MP0002572_abnormal_emotion/affect_behav	0.92236733
74	MP0001324_abnormal_eye_pigmentation	0.91196950
75	MP0005389_reproductive_system_phenotype	0.90956905
76	MP0002095_abnormal_skin_pigmentation	0.89718178
77	MP0000653_abnormal_sex_gland	0.89663600
78	MP0010678_abnormal_skin_adnexa	0.89297690
79	MP0003806_abnormal_nucleotide_metabolis	0.89197997
80	MP0008775_abnormal_heart_ventricle	0.88200514
81	MP0004924_abnormal_behavior	0.87776779
82	MP0005386_behavior/neurological_phenoty	0.87776779
83	MP0000358_abnormal_cell_content/	0.87712747
84	MP0009764_decreased_sensitivity_to	0.87468893
85	MP0002229_neurodegeneration	0.87462718
86	MP0001756_abnormal_urination	0.87367336
87	MP0000013_abnormal_adipose_tissue	0.85327098
88	MP0002138_abnormal_hepatobiliary_system	0.85082325
89	MP0003698_abnormal_male_reproductive	0.83753069
90	MP0005379_endocrine/exocrine_gland_phen	0.83343129
91	MP0010094_abnormal_chromosome_stability	0.83153457
92	MP0008875_abnormal_xenobiotic_pharmacok	0.82767516
93	MP0001145_abnormal_male_reproductive	0.82572056
94	MP0004145_abnormal_muscle_electrophysio	0.80983149
95	MP0005395_other_phenotype	0.80546684
96	MP0002064_seizures	0.79054861
97	MP0002653_abnormal_ependyma_morphology	0.78308619
98	MP0001970_abnormal_pain_threshold	0.77308388
99	MP0001119_abnormal_female_reproductive	0.76850349
100	MP0002163_abnormal_gland_morphology	0.76718937

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	3.39107192
2	Hyperalaninemia (HP:0003348)	3.39107192
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.39107192
4	Progressive macrocephaly (HP:0004481)	3.28675298
5	Renal Fanconi syndrome (HP:0001994)	3.28314433
6	Lipid accumulation in hepatocytes (HP:0006561)	3.18620705
7	Acute necrotizing encephalopathy (HP:0006965)	3.17921103
8	Neoplasm of the adrenal cortex (HP:0100641)	3.13707750
9	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.12344196
10	Abnormal protein N-linked glycosylation (HP:0012347)	3.12344196
11	Abnormal protein glycosylation (HP:0012346)	3.12344196
12	Abnormal glycosylation (HP:0012345)	3.12344196
13	Increased intramyocellular lipid droplets (HP:0012240)	3.12060827
14	Acute encephalopathy (HP:0006846)	3.11429178
15	Increased hepatocellular lipid droplets (HP:0006565)	3.09954318
16	Methylmalonic acidemia (HP:0002912)	2.97144535
17	Mitochondrial inheritance (HP:0001427)	2.92580095
18	Exertional dyspnea (HP:0002875)	2.92362624
19	Type I transferrin isoform profile (HP:0003642)	2.92073903
20	Medial flaring of the eyebrow (HP:0010747)	2.88172619
21	Abnormal mitochondria in muscle tissue (HP:0008316)	2.82469502
22	Increased CSF lactate (HP:0002490)	2.80139968
23	Dry hair (HP:0011359)	2.76634320
24	Abnormality of urine glucose concentration (HP:0011016)	2.76506678
25	Glycosuria (HP:0003076)	2.76506678
26	Pancreatic cysts (HP:0001737)	2.68490765
27	Increased muscle lipid content (HP:0009058)	2.67240387
28	Abnormality of renal resorption (HP:0011038)	2.59358421
29	Renal cortical cysts (HP:0000803)	2.56764079
30	3-Methylglutaconic aciduria (HP:0003535)	2.54467744
31	Hepatic necrosis (HP:0002605)	2.50607394
32	Congenital, generalized hypertrichosis (HP:0004540)	2.50360089
33	Nephronophthisis (HP:0000090)	2.50119318
34	Congenital primary aphakia (HP:0007707)	2.50101981
35	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.47087347
36	Methylmalonic aciduria (HP:0012120)	2.46103669
37	Generalized aminoaciduria (HP:0002909)	2.44327064
38	Polyphagia (HP:0002591)	2.42744531
39	Gait imbalance (HP:0002141)	2.41567871
40	Pancreatic fibrosis (HP:0100732)	2.41269787
41	True hermaphroditism (HP:0010459)	2.40479264
42	Hypothermia (HP:0002045)	2.37802376
43	Congenital stationary night blindness (HP:0007642)	2.32995210
44	Abnormality of the renal medulla (HP:0100957)	2.29765463
45	Hypoplasia of the fovea (HP:0007750)	2.29110347
46	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.29110347
47	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.28876525
48	Nephrogenic diabetes insipidus (HP:0009806)	2.27206945
49	Type II lissencephaly (HP:0007260)	2.26099975
50	Fair hair (HP:0002286)	2.21149711
51	Abnormality of the renal cortex (HP:0011035)	2.20497773
52	Hypoglycemic coma (HP:0001325)	2.18482695
53	Reduced antithrombin III activity (HP:0001976)	2.17738590
54	Hyperglycinemia (HP:0002154)	2.13356044
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.11530335
56	Increased serum lactate (HP:0002151)	2.10377260
57	Abnormality of the axillary hair (HP:0100134)	2.08536741
58	Abnormality of secondary sexual hair (HP:0009888)	2.08536741
59	Hypomagnesemia (HP:0002917)	2.07218874
60	Azoospermia (HP:0000027)	2.04647761
61	Abolished electroretinogram (ERG) (HP:0000550)	2.02276669
62	Sensory axonal neuropathy (HP:0003390)	2.01343201
63	Limb dystonia (HP:0002451)	2.01173766
64	Abnormal spermatogenesis (HP:0008669)	2.00264144
65	Cerebral edema (HP:0002181)	1.98805643
66	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.98652392
67	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.98652392
68	Hepatocellular necrosis (HP:0001404)	1.98212052
69	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.95361558
70	Dicarboxylic aciduria (HP:0003215)	1.95361558
71	Severe visual impairment (HP:0001141)	1.94379917
72	Thyroid carcinoma (HP:0002890)	1.92711700
73	Molar tooth sign on MRI (HP:0002419)	1.92600807
74	Abnormality of midbrain morphology (HP:0002418)	1.92600807
75	Neoplasm of the adrenal gland (HP:0100631)	1.92437315
76	Abnormality of the fovea (HP:0000493)	1.92241435
77	Cutaneous melanoma (HP:0012056)	1.91936673
78	Dyschromatopsia (HP:0007641)	1.91351058
79	Cerebellar dysplasia (HP:0007033)	1.91331185
80	Growth hormone deficiency (HP:0000824)	1.90965395
81	Pendular nystagmus (HP:0012043)	1.90841147
82	Lethargy (HP:0001254)	1.90608784
83	Lactic acidosis (HP:0003128)	1.89241034
84	Congenital sensorineural hearing impairment (HP:0008527)	1.88603329
85	Generalized hypopigmentation of hair (HP:0011358)	1.87154884
86	Pachygyria (HP:0001302)	1.84320233
87	Tongue fasciculations (HP:0001308)	1.84123340
88	Specific learning disability (HP:0001328)	1.83384616
89	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.81895854
90	Poor suck (HP:0002033)	1.80542582
91	Confusion (HP:0001289)	1.77315779
92	Amblyopia (HP:0000646)	1.76746239
93	Delusions (HP:0000746)	1.76540773
94	Exercise intolerance (HP:0003546)	1.76382978
95	Abnormality of serum amino acid levels (HP:0003112)	1.74230595
96	Aplasia/hypoplasia of the uterus (HP:0008684)	1.73437036
97	Abnormality of vitamin B metabolism (HP:0004340)	1.72839019
98	Papillary thyroid carcinoma (HP:0002895)	1.71965186
99	Ketoacidosis (HP:0001993)	1.71861346
100	Male pseudohermaphroditism (HP:0000037)	1.71115481

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.53994493
2	ZAK	3.35998416
3	NUAK1	3.24784004
4	PLK2	2.97545254
5	MST4	2.83396564
6	TAOK3	2.76114579
7	PBK	2.62338826
8	TRIM28	2.61292533
9	LATS1	2.60553825
10	BMPR1B	1.95965246
11	PLK4	1.91274770
12	STK38L	1.69174286
13	PDK2	1.64103249
14	MAP3K4	1.62591286
15	PLK3	1.62498893
16	CSNK1G3	1.62044654
17	CSNK1G1	1.59678834
18	ERBB3	1.58951740
19	CSNK1G2	1.54073860
20	ADRBK2	1.51357003
21	ACVR1B	1.48169847
22	TTK	1.43075420
23	CDC7	1.34987446
24	MAP3K6	1.31114852
25	CSNK1A1L	1.21983380
26	PINK1	1.21368304
27	GRK1	1.19920697
28	PAK3	1.18411371
29	TNIK	1.15857833
30	MKNK2	1.05607394
31	AKT3	1.05408073
32	NEK1	1.04747912
33	PNCK	1.03168903
34	ADRBK1	1.02365182
35	TAF1	0.96522124
36	CASK	0.95886924
37	FGFR2	0.95544035
38	BUB1	0.95419584
39	EIF2AK1	0.92652840
40	GRK5	0.92260330
41	MAPK13	0.89846881
42	PLK1	0.88921332
43	MAP2K7	0.88450384
44	BCKDK	0.86825752
45	MINK1	0.86761232
46	WNK3	0.83229230
47	CAMKK2	0.82667849
48	MAP2K4	0.82235496
49	STK3	0.81114947
50	CAMK1G	0.81084844
51	PRKCI	0.80722146
52	MAP3K9	0.79300988
53	MARK1	0.78923461
54	SCYL2	0.77643003
55	PTK2B	0.73830644
56	WEE1	0.72144907
57	BCR	0.71883944
58	VRK1	0.68533916
59	OXSR1	0.68518304
60	MKNK1	0.67454787
61	PRKCE	0.67299071
62	CCNB1	0.66490380
63	BRSK2	0.60333502
64	MYLK	0.60102558
65	MAP3K12	0.60000338
66	GRK7	0.59978160
67	PRKCG	0.58182748
68	PHKG2	0.56366317
69	PHKG1	0.56366317
70	NEK9	0.56324936
71	NTRK3	0.55536151
72	MAP2K6	0.54177683
73	FER	0.52118997
74	SRPK1	0.50248611
75	CAMK1D	0.50218857
76	IRAK1	0.49560231
77	DAPK2	0.47858336
78	MAP4K2	0.47142580
79	TNK2	0.46289810
80	DYRK2	0.45115355
81	CAMK2A	0.44836537
82	CDK19	0.44076996
83	DAPK1	0.42390158
84	MAP3K5	0.41562748
85	TIE1	0.40672255
86	ATR	0.39151172
87	EPHB2	0.37718904
88	EIF2AK3	0.37322915
89	STK16	0.35428238
90	PRKACA	0.34434510
91	MAPK7	0.33438655
92	PRKCA	0.33038118
93	CDK3	0.32196112
94	ATM	0.31309954
95	CSNK1A1	0.30566904
96	BMPR2	0.30422661
97	INSRR	0.29571301
98	PRKG1	0.29317853
99	CSF1R	0.28161691
100	PIK3CG	0.27964266

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.43669890
2	Fatty acid elongation_Homo sapiens_hsa00062	3.25028994
3	Collecting duct acid secretion_Homo sapiens_hsa04966	2.93535938
4	Protein export_Homo sapiens_hsa03060	2.90457780
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.53516551
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.33540304
7	Basal transcription factors_Homo sapiens_hsa03022	2.24226946
8	Proteasome_Homo sapiens_hsa03050	2.20120666
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.17720791
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.06920182
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.92022780
12	Butanoate metabolism_Homo sapiens_hsa00650	1.86044961
13	Parkinsons disease_Homo sapiens_hsa05012	1.82029944
14	Homologous recombination_Homo sapiens_hsa03440	1.73116352
15	Peroxisome_Homo sapiens_hsa04146	1.70748756
16	Phototransduction_Homo sapiens_hsa04744	1.70650544
17	RNA degradation_Homo sapiens_hsa03018	1.64587093
18	Mismatch repair_Homo sapiens_hsa03430	1.62652820
19	Sulfur metabolism_Homo sapiens_hsa00920	1.60017658
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59685565
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.58552552
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.52948032
23	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.50064267
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.48210635
25	Propanoate metabolism_Homo sapiens_hsa00640	1.44465856
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.41230940
27	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.36981976
28	RNA polymerase_Homo sapiens_hsa03020	1.35673027
29	Folate biosynthesis_Homo sapiens_hsa00790	1.34277123
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.31599350
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.29924535
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28552432
33	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.25946213
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.25646786
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.24342118
36	Caffeine metabolism_Homo sapiens_hsa00232	1.19019764
37	Base excision repair_Homo sapiens_hsa03410	1.18900008
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.18088136
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17584749
40	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.16939973
41	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.13891243
42	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.13492718
43	Olfactory transduction_Homo sapiens_hsa04740	1.12624751
44	Huntingtons disease_Homo sapiens_hsa05016	1.11195317
45	Nicotine addiction_Homo sapiens_hsa05033	1.09022714
46	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.07603144
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06957266
48	Vibrio cholerae infection_Homo sapiens_hsa05110	1.04470442
49	Alzheimers disease_Homo sapiens_hsa05010	1.04072705
50	Purine metabolism_Homo sapiens_hsa00230	1.02691547
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99607976
52	Glutathione metabolism_Homo sapiens_hsa00480	0.99447122
53	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.96796699
54	Rheumatoid arthritis_Homo sapiens_hsa05323	0.94928160
55	Oocyte meiosis_Homo sapiens_hsa04114	0.93882317
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.91374161
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.91091606
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.88174965
59	Metabolic pathways_Homo sapiens_hsa01100	0.86406542
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85838150
61	Retinol metabolism_Homo sapiens_hsa00830	0.84209641
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.80466127
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80296705
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79617036
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79382128
66	Fatty acid degradation_Homo sapiens_hsa00071	0.78592846
67	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.77978142
68	Tryptophan metabolism_Homo sapiens_hsa00380	0.77312577
69	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.74937010
70	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.72102879
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67989926
72	Taste transduction_Homo sapiens_hsa04742	0.67203432
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.66886736
74	Nitrogen metabolism_Homo sapiens_hsa00910	0.64407587
75	One carbon pool by folate_Homo sapiens_hsa00670	0.63241236
76	DNA replication_Homo sapiens_hsa03030	0.62888680
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60312665
78	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58356904
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.57557805
80	Cardiac muscle contraction_Homo sapiens_hsa04260	0.57065031
81	Sphingolipid metabolism_Homo sapiens_hsa00600	0.56562212
82	p53 signaling pathway_Homo sapiens_hsa04115	0.53388010
83	Morphine addiction_Homo sapiens_hsa05032	0.52197308
84	Serotonergic synapse_Homo sapiens_hsa04726	0.51758699
85	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.50674646
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.50096812
87	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.50043462
88	Regulation of autophagy_Homo sapiens_hsa04140	0.48355559
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46901824
90	RNA transport_Homo sapiens_hsa03013	0.45716997
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42513479
92	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.39742932
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.39554716
94	Mineral absorption_Homo sapiens_hsa04978	0.39444182
95	Cell cycle_Homo sapiens_hsa04110	0.38352106
96	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37402626
97	Insulin secretion_Homo sapiens_hsa04911	0.35610645
98	GABAergic synapse_Homo sapiens_hsa04727	0.35499310
99	Melanoma_Homo sapiens_hsa05218	0.32586481
100	Glutamatergic synapse_Homo sapiens_hsa04724	0.30833243

C7ORF25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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