C7ORF31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)8.55674282
2acrosome reaction (GO:0007340)8.04128881
3fusion of sperm to egg plasma membrane (GO:0007342)7.32087242
4rRNA methylation (GO:0031167)7.03576265
5chromosome condensation (GO:0030261)6.99768122
6DNA packaging (GO:0006323)6.90636989
7piRNA metabolic process (GO:0034587)6.86923557
8protein targeting to Golgi (GO:0000042)6.51124865
9establishment of protein localization to Golgi (GO:0072600)6.19422087
10spermatid development (GO:0007286)6.14136543
11retrograde transport, vesicle recycling within Golgi (GO:0000301)6.05505520
12sperm capacitation (GO:0048240)6.00755398
13rRNA modification (GO:0000154)5.79431868
14protein polyglutamylation (GO:0018095)5.70562183
15DNA methylation involved in gamete generation (GO:0043046)5.42981688
16sperm-egg recognition (GO:0035036)5.41249630
17plasma membrane fusion (GO:0045026)5.33571958
18microtubule depolymerization (GO:0007019)5.29663444
19single strand break repair (GO:0000012)5.27672124
20centriole replication (GO:0007099)5.22902861
21seminiferous tubule development (GO:0072520)5.13891473
22spermatogenesis (GO:0007283)5.11727744
23spermatid nucleus differentiation (GO:0007289)5.11564945
24male gamete generation (GO:0048232)5.11056604
25phosphatidylethanolamine biosynthetic process (GO:0006646)5.02780463
26microtubule severing (GO:0051013)4.96718245
27centriole assembly (GO:0098534)4.94067992
28binding of sperm to zona pellucida (GO:0007339)4.88782364
29protein localization to Golgi apparatus (GO:0034067)4.75466108
30multicellular organism reproduction (GO:0032504)4.74174716
31gamete generation (GO:0007276)4.73770978
32phosphatidylethanolamine metabolic process (GO:0046337)4.65153371
33male meiosis I (GO:0007141)4.61500909
34cell-cell recognition (GO:0009988)4.58222769
35microtubule polymerization or depolymerization (GO:0031109)4.54675318
36reproduction (GO:0000003)4.47789145
37cell wall macromolecule catabolic process (GO:0016998)4.42912191
38sexual reproduction (GO:0019953)4.40703477
39response to pheromone (GO:0019236)4.23976084
40calcium ion-dependent exocytosis (GO:0017156)4.13533881
41negative regulation of inclusion body assembly (GO:0090084)4.06856391
42cell wall macromolecule metabolic process (GO:0044036)4.01438613
43male meiosis (GO:0007140)3.97637443
44RNA destabilization (GO:0050779)3.95816364
45histone H3-K9 demethylation (GO:0033169)3.93274674
46microtubule nucleation (GO:0007020)3.91925665
47single fertilization (GO:0007338)3.83170668
48fertilization (GO:0009566)3.82911151
49germ cell development (GO:0007281)3.82387977
50multicellular organismal reproductive process (GO:0048609)3.81065083
51regulation of meiosis I (GO:0060631)3.77135861
52nuclear pore complex assembly (GO:0051292)3.73811741
53nucleus organization (GO:0006997)3.72958000
54positive regulation of Rab GTPase activity (GO:0032851)3.63069074
55regulation of Rab GTPase activity (GO:0032313)3.63069074
56meiosis I (GO:0007127)3.54068620
57cellular process involved in reproduction in multicellular organism (GO:0022412)3.54020093
58synapsis (GO:0007129)3.53719970
59chromosome organization involved in meiosis (GO:0070192)3.51475998
60cilium or flagellum-dependent cell motility (GO:0001539)3.50861852
61regulation of cilium movement (GO:0003352)3.45714238
62axonemal dynein complex assembly (GO:0070286)3.45235499
63motile cilium assembly (GO:0044458)3.36932070
64pore complex assembly (GO:0046931)3.36813472
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.36177608
66synaptonemal complex assembly (GO:0007130)3.34396566
67meiotic nuclear division (GO:0007126)3.32787525
68regulation of T-helper 2 cell differentiation (GO:0045628)3.32511156
69nuclear pore organization (GO:0006999)3.20282148
70regulation of microtubule-based movement (GO:0060632)3.09095377
71regulation of centriole replication (GO:0046599)3.05443581
72regulation of histone H3-K9 methylation (GO:0051570)3.05052211
73macrophage activation involved in immune response (GO:0002281)3.04263212
74membrane protein intracellular domain proteolysis (GO:0031293)3.03868433
75positive regulation of type 2 immune response (GO:0002830)3.03331712
76neutrophil activation involved in immune response (GO:0002283)3.03079578
77intra-Golgi vesicle-mediated transport (GO:0006891)3.01410790
78negative regulation of granulocyte differentiation (GO:0030853)2.87461561
79positive regulation of gamma-delta T cell activation (GO:0046645)2.86704546
80negative regulation of Rho protein signal transduction (GO:0035024)2.85465046
81positive regulation by organism of defense response of other organism involved in symbiotic interact2.84928405
82modulation by symbiont of host immune response (GO:0052553)2.84928405
83positive regulation by symbiont of host defense response (GO:0052509)2.84928405
84modulation by symbiont of host defense response (GO:0052031)2.84928405
85modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84928405
86modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84928405
87resolution of meiotic recombination intermediates (GO:0000712)2.84265964
88cellular ketone body metabolic process (GO:0046950)2.80315230
89regulation of B cell receptor signaling pathway (GO:0050855)2.79180931
90homeostasis of number of cells within a tissue (GO:0048873)2.79102156
91histone H3-K36 demethylation (GO:0070544)2.78735879
92epithelial cilium movement (GO:0003351)2.77920475
93synaptonemal complex organization (GO:0070193)2.76812739
94meiotic cell cycle process (GO:1903046)2.74868716
95polyamine biosynthetic process (GO:0006596)2.73953250
96myeloid cell activation involved in immune response (GO:0002275)2.72495497
97definitive hemopoiesis (GO:0060216)2.72316307
98response to peptidoglycan (GO:0032494)2.62711825
99positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.60758020
100meiotic cell cycle (GO:0051321)2.60631706

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.22521301
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.00935036
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.81691798
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.36997033
5VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.64813042
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.29482748
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.23021650
8RUNX_20019798_ChIP-Seq_JUKART_Human2.19187235
9ELF1_20517297_ChIP-Seq_JURKAT_Human2.14025596
10MYB_26560356_Chip-Seq_TH2_Human2.03813475
11TP63_19390658_ChIP-ChIP_HaCaT_Human1.98848755
12* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92283896
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86721357
14BCL6_27268052_Chip-Seq_Bcells_Human1.79003910
15YY1_22570637_ChIP-Seq_MALME-3M_Human1.69555896
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68814168
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.68814168
18RAC3_21632823_ChIP-Seq_H3396_Human1.68642229
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66507180
20SCL_19346495_ChIP-Seq_HPC-7_Human1.66030387
21NANOG_20526341_ChIP-Seq_ESCs_Human1.62934112
22RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.60048019
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59589479
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57474182
25VDR_24787735_ChIP-Seq_THP-1_Human1.57043698
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.56664221
27CBP_20019798_ChIP-Seq_JUKART_Human1.56413393
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56413393
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55130978
30BCOR_27268052_Chip-Seq_Bcells_Human1.53503432
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53417586
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.52854542
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.51447335
34FUS_26573619_Chip-Seq_HEK293_Human1.50879092
35P300_27268052_Chip-Seq_Bcells_Human1.50633864
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47900789
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44747541
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43748060
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43204127
40MYC_19829295_ChIP-Seq_ESCs_Human1.42887281
41CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.42024228
42PHF8_20622854_ChIP-Seq_HELA_Human1.41982511
43SMRT_27268052_Chip-Seq_Bcells_Human1.40446065
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40186625
45ERA_21632823_ChIP-Seq_H3396_Human1.39958087
46GATA3_27048872_Chip-Seq_THYMUS_Human1.37893598
47MYB_26560356_Chip-Seq_TH1_Human1.37668544
48GATA3_26560356_Chip-Seq_TH2_Human1.37369908
49EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.37248578
50SPI1_23127762_ChIP-Seq_K562_Human1.37154515
51TAF2_19829295_ChIP-Seq_ESCs_Human1.36522681
52ERG_20517297_ChIP-Seq_VCAP_Human1.35263603
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33873689
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27519558
55E2F1_20622854_ChIP-Seq_HELA_Human1.27314960
56GATA3_26560356_Chip-Seq_TH1_Human1.26310879
57* SPI1_23547873_ChIP-Seq_NB4_Human1.20545019
58P68_20966046_ChIP-Seq_HELA_Human1.19666497
59* CEBPB_22108803_ChIP-Seq_LS180_Human1.19057589
60* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.17425561
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17299758
62MAF_26560356_Chip-Seq_TH2_Human1.16864721
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.16814778
64SMC4_20622854_ChIP-Seq_HELA_Human1.16201527
65RBPJ_21746931_ChIP-Seq_IB4_Human1.15636315
66IGF1R_20145208_ChIP-Seq_DFB_Human1.15146723
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14410866
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13422543
69VDR_24763502_ChIP-Seq_THP-1_Human1.12978893
70WDR5_24793694_ChIP-Seq_LNCAP_Human1.11344672
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11032940
72P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.09655338
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08895658
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06747188
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06602442
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06464799
77CTCF_20526341_ChIP-Seq_ESCs_Human1.06263826
78HNFA_21074721_ChIP-Seq_CACO-2_Human1.06212844
79UTX_26944678_Chip-Seq_JUKART_Human1.05658401
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05630191
81ETV1_20927104_ChIP-Seq_GIST48_Human1.05140117
82OCT4_20526341_ChIP-Seq_ESCs_Human1.04608948
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03310233
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03263293
85TP63_22573176_ChIP-Seq_HFKS_Human1.02431673
86CBX2_22325352_ChIP-Seq_293T-Rex_Human1.01980883
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01778774
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00946159
89ER_23166858_ChIP-Seq_MCF-7_Human1.00873409
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00278382
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00206944
92EZH2_22144423_ChIP-Seq_EOC_Human0.98718575
93PRDM14_20953172_ChIP-Seq_ESCs_Human0.98682345
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.98301824
95SMAD4_21741376_ChIP-Seq_EPCs_Human0.97685332
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97607589
97GATA6_21074721_ChIP-Seq_CACO-2_Human0.97437176
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.97143650
99FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96758119
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96636174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.16526043
2MP0003698_abnormal_male_reproductive3.46127288
3MP0001929_abnormal_gametogenesis3.41443263
4MP0005451_abnormal_body_composition3.37580680
5MP0003878_abnormal_ear_physiology3.19855361
6MP0005377_hearing/vestibular/ear_phenot3.19855361
7MP0005670_abnormal_white_adipose2.98884359
8MP0001835_abnormal_antigen_presentation2.69655879
9MP0005671_abnormal_response_to2.32236856
10MP0005310_abnormal_salivary_gland2.27877292
11MP0001800_abnormal_humoral_immune2.20145063
12MP0003436_decreased_susceptibility_to2.18645230
13MP0002132_abnormal_respiratory_system2.16928761
14MP0002210_abnormal_sex_determination2.16764617
15MP0008877_abnormal_DNA_methylation2.11091936
16MP0003303_peritoneal_inflammation2.07828226
17MP0000685_abnormal_immune_system2.04460796
18MP0005379_endocrine/exocrine_gland_phen2.03487656
19MP0002723_abnormal_immune_serum1.92178754
20MP0005000_abnormal_immune_tolerance1.89913720
21MP0002161_abnormal_fertility/fecundity1.88908824
22MP0000678_abnormal_parathyroid_gland1.84627307
23MP0009785_altered_susceptibility_to1.80234183
24MP0005387_immune_system_phenotype1.79440371
25MP0001790_abnormal_immune_system1.79440371
26MP0002452_abnormal_antigen_presenting1.77414028
27MP0002148_abnormal_hypersensitivity_rea1.77005188
28MP0001145_abnormal_male_reproductive1.74916010
29MP0005397_hematopoietic_system_phenotyp1.73423977
30MP0001545_abnormal_hematopoietic_system1.73423977
31MP0000653_abnormal_sex_gland1.60826632
32MP0003646_muscle_fatigue1.60327516
33MP0002420_abnormal_adaptive_immunity1.56276831
34MP0005084_abnormal_gallbladder_morpholo1.55916893
35MP0002398_abnormal_bone_marrow1.55218812
36MP0001819_abnormal_immune_cell1.54541284
37MP0002419_abnormal_innate_immunity1.53894453
38MP0005025_abnormal_response_to1.52779267
39MP0003718_maternal_effect1.51773164
40MP0003172_abnormal_lysosome_physiology1.46717114
41MP0005464_abnormal_platelet_physiology1.44705173
42MP0002138_abnormal_hepatobiliary_system1.37234108
43MP0000716_abnormal_immune_system1.33039436
44MP0006082_CNS_inflammation1.32596914
45MP0009764_decreased_sensitivity_to1.27950035
46MP0000015_abnormal_ear_pigmentation1.27718146
47MP0001348_abnormal_lacrimal_gland1.27544963
48MP0003763_abnormal_thymus_physiology1.26478760
49MP0009278_abnormal_bone_marrow1.25656001
50MP0002405_respiratory_system_inflammati1.25580820
51MP0002163_abnormal_gland_morphology1.22946585
52MP0002722_abnormal_immune_system1.22649520
53MP0000689_abnormal_spleen_morphology1.20042293
54MP0000703_abnormal_thymus_morphology1.16980108
55MP0004947_skin_inflammation1.08844780
56MP0002429_abnormal_blood_cell1.07966026
57MP0004808_abnormal_hematopoietic_stem1.06865467
58MP0003724_increased_susceptibility_to1.06620984
59MP0001853_heart_inflammation1.05802044
60MP0010307_abnormal_tumor_latency1.03032508
61MP0000681_abnormal_thyroid_gland1.02852119
62MP0009333_abnormal_splenocyte_physiolog0.99688909
63MP0008469_abnormal_protein_level0.98293070
64MP0004510_myositis0.96894549
65MP0009115_abnormal_fat_cell0.95529766
66MP0001845_abnormal_inflammatory_respons0.92137563
67MP0008004_abnormal_stomach_pH0.91928598
68MP0001533_abnormal_skeleton_physiology0.90119042
69MP0005058_abnormal_lysosome_morphology0.88237427
70MP0005174_abnormal_tail_pigmentation0.87398302
71MP0001873_stomach_inflammation0.84273952
72MP0003879_abnormal_hair_cell0.80564845
73MP0009765_abnormal_xenobiotic_induced0.77307772
74MP0008995_early_reproductive_senescence0.76112802
75MP0005666_abnormal_adipose_tissue0.73853830
76MP0001765_abnormal_ion_homeostasis0.71698641
77MP0010155_abnormal_intestine_physiology0.71000577
78MP0001188_hyperpigmentation0.69169663
79MP0002998_abnormal_bone_remodeling0.67811715
80MP0003693_abnormal_embryo_hatching0.65563754
81MP0005535_abnormal_body_temperature0.64861307
82MP0008058_abnormal_DNA_repair0.64682872
83MP0002166_altered_tumor_susceptibility0.64473060
84MP0003077_abnormal_cell_cycle0.63781690
85MP0005075_abnormal_melanosome_morpholog0.63701663
86MP0003656_abnormal_erythrocyte_physiolo0.63378507
87MP0005167_abnormal_blood-brain_barrier0.63318663
88MP0000313_abnormal_cell_death0.61313921
89MP0004957_abnormal_blastocyst_morpholog0.61299745
90MP0003011_delayed_dark_adaptation0.58581541
91MP0003959_abnormal_lean_body0.58118325
92MP0004742_abnormal_vestibular_system0.55918949
93MP0002019_abnormal_tumor_incidence0.54545811
94MP0003699_abnormal_female_reproductive0.54210950
95MP0001764_abnormal_homeostasis0.54064458
96MP0000249_abnormal_blood_vessel0.53561035
97MP0002928_abnormal_bile_duct0.52310904
98MP0002693_abnormal_pancreas_physiology0.51981343
99MP0001485_abnormal_pinna_reflex0.50803146
100MP0006292_abnormal_olfactory_placode0.49313253

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.72741326
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.69229843
3Tubulointerstitial nephritis (HP:0001970)5.14852325
4Hypoplasia of the thymus (HP:0000778)4.63728013
5Asymmetric septal hypertrophy (HP:0001670)4.25671221
6Absent/shortened dynein arms (HP:0200106)4.22978823
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.22978823
8Menstrual irregularities (HP:0000858)4.21966726
9Chronic hepatic failure (HP:0100626)3.92446636
10Male infertility (HP:0003251)3.50039523
11Hyperkalemia (HP:0002153)3.39287032
12Resting tremor (HP:0002322)3.32795749
13Abnormal spermatogenesis (HP:0008669)3.21587316
14Cone-rod dystrophy (HP:0000548)3.20955980
15Gastrointestinal infarctions (HP:0005244)3.17681073
16Abnormality of macular pigmentation (HP:0008002)3.15753063
17Azoospermia (HP:0000027)3.08000771
18Abnormality of dental color (HP:0011073)3.05420601
19Nasal polyposis (HP:0100582)3.05254308
20Aplasia/Hypoplasia of the earlobes (HP:0009906)3.01554015
21Attenuation of retinal blood vessels (HP:0007843)2.90435847
22Impulsivity (HP:0100710)2.89344839
23Truncal obesity (HP:0001956)2.89253128
24Recurrent pneumonia (HP:0006532)2.88287683
25Chronic obstructive pulmonary disease (HP:0006510)2.88141513
26Obstructive lung disease (HP:0006536)2.88141513
27Abnormal ciliary motility (HP:0012262)2.86661064
28Bony spicule pigmentary retinopathy (HP:0007737)2.83139162
29Abnormal respiratory motile cilium physiology (HP:0012261)2.79508693
30Infertility (HP:0000789)2.77624175
31Aplasia/Hypoplasia of the thymus (HP:0010515)2.76539418
32Abnormal respiratory epithelium morphology (HP:0012253)2.64470440
33Abnormal respiratory motile cilium morphology (HP:0005938)2.64470440
34Abnormality of the costochondral junction (HP:0000919)2.54844901
35Vasculitis (HP:0002633)2.45418160
36Abnormality of macrophages (HP:0004311)2.43553603
37Hypoalphalipoproteinemia (HP:0003233)2.41794316
38Abnormality of the nasal mucosa (HP:0000433)2.40849079
39Osteomalacia (HP:0002749)2.40573626
40Progressive sensorineural hearing impairment (HP:0000408)2.40484071
41Abnormality of DNA repair (HP:0003254)2.39064286
42Nephronophthisis (HP:0000090)2.38097070
43Pulmonary fibrosis (HP:0002206)2.38031391
44Stomatitis (HP:0010280)2.37664042
45Failure to thrive in infancy (HP:0001531)2.36910967
46Gingivitis (HP:0000230)2.36808809
47Enlarged epiphyses (HP:0010580)2.36265560
48Tubulointerstitial abnormality (HP:0001969)2.35168667
49Abnormal rod and cone electroretinograms (HP:0008323)2.33474329
50Meningitis (HP:0001287)2.30551353
51Portal hypertension (HP:0001409)2.26781533
52T lymphocytopenia (HP:0005403)2.25467903
53Abnormality of the hepatic vasculature (HP:0006707)2.24357288
54Amelogenesis imperfecta (HP:0000705)2.23668154
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19508096
56Bell-shaped thorax (HP:0001591)2.17348752
57Recurrent fungal infections (HP:0002841)2.17219840
58Inflammation of the large intestine (HP:0002037)2.16763097
59Hypergonadotropic hypogonadism (HP:0000815)2.15780640
60Gastrointestinal stroma tumor (HP:0100723)2.15196131
61Postural instability (HP:0002172)2.14945655
62Gastrointestinal inflammation (HP:0004386)2.13533710
63Recurrent bacterial skin infections (HP:0005406)2.11083975
64Panhypogammaglobulinemia (HP:0003139)2.10604883
65Agammaglobulinemia (HP:0004432)2.09933607
66Renal Fanconi syndrome (HP:0001994)2.08620585
67Abnormality of T cell number (HP:0011839)2.08483107
68Recurrent lower respiratory tract infections (HP:0002783)2.07156883
69Generalized aminoaciduria (HP:0002909)2.05852584
70Recurrent abscess formation (HP:0002722)2.05434994
71Retrobulbar optic neuritis (HP:0100654)2.05100983
72Optic neuritis (HP:0100653)2.05100983
73Abnormality of the thymus (HP:0000777)2.05061876
74Unilateral renal agenesis (HP:0000122)2.01718119
75Abnormality of T cells (HP:0002843)2.01604950
76Peritonitis (HP:0002586)2.00544458
77Acute hepatic failure (HP:0006554)2.00487203
78Colitis (HP:0002583)1.99367508
79Horizontal nystagmus (HP:0000666)1.98945812
80Elevated erythrocyte sedimentation rate (HP:0003565)1.98888517
81Mediastinal lymphadenopathy (HP:0100721)1.98435469
82Pulmonary infiltrates (HP:0002113)1.98012217
83Subcapsular cataract (HP:0000523)1.94487740
84Stage 5 chronic kidney disease (HP:0003774)1.93157436
85Abnormality of the renal medulla (HP:0100957)1.91749704
86Chest pain (HP:0100749)1.91228906
87Glomerulopathy (HP:0100820)1.89089855
88Fatigue (HP:0012378)1.88788916
89Recurrent viral infections (HP:0004429)1.88342695
90Progressive hearing impairment (HP:0001730)1.87765337
91Facial shape deformation (HP:0011334)1.86146389
92Potter facies (HP:0002009)1.86146389
93Progressive cerebellar ataxia (HP:0002073)1.86046170
94Leukocytosis (HP:0001974)1.84473920
95Abnormality of lateral ventricle (HP:0030047)1.83065999
96Hypertensive crisis (HP:0100735)1.82604929
97Insulin-resistant diabetes mellitus (HP:0000831)1.81608031
98Thrombocytosis (HP:0001894)1.81378156
99Orchitis (HP:0100796)1.81328023
100Myositis (HP:0100614)1.81030112

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.13095903
2BRD43.91107539
3RIPK43.72231874
4PNCK2.80023253
5CDK192.75700008
6DDR22.57033093
7PIK3CG2.46701792
8TESK12.46624308
9INSRR2.36459524
10STK382.30283872
11PLK22.23196732
12TXK2.11169669
13CAMK1G1.88955667
14CDK121.79432696
15TYRO31.74907332
16MAP4K11.74226989
17MATK1.67382285
18JAK31.51996364
19PDK11.50560785
20PDPK11.41153795
21KIT1.40957256
22MAP3K141.34513528
23SYK1.34289944
24MAP4K21.31542311
25PRPF4B1.30258519
26BMPR21.29848914
27DYRK1B1.28732839
28BLK1.28053283
29STK38L1.27790616
30TAOK31.26792352
31MAP3K131.25926275
32TAF11.24779112
33TEC1.23832532
34PRKD31.18084886
35PTK2B1.16246317
36MAP3K21.08836555
37MAP3K111.08610681
38CSF1R1.07266515
39CSK1.00240658
40CDK70.92847206
41BTK0.86410977
42KSR20.86150900
43IRAK40.83919159
44TYK20.81775703
45ACVR1B0.80545808
46FGFR30.80075306
47IKBKB0.79523497
48WNK10.79297471
49TBK10.78873234
50MAP3K10.74147016
51GRK70.72489690
52CDK30.70478236
53MAP2K30.69726096
54STK30.67151880
55TIE10.65630479
56SIK20.64282783
57MAPK150.60581722
58PRKCQ0.59655223
59LYN0.58548296
60CDK40.58129229
61ZAP700.57509419
62MAP3K70.56561185
63NEK60.55635869
64MARK30.54547811
65JAK20.54121977
66TAOK20.53231738
67HCK0.51501186
68STK240.51251745
69CDK90.49679083
70ERN10.49640421
71ITK0.49605372
72LCK0.49520448
73WNK40.47542161
74RPS6KC10.46653418
75RPS6KL10.46653418
76MAP3K40.44909259
77MST1R0.42419811
78FES0.42004067
79NUAK10.41132397
80RPS6KA10.40625855
81PRKD20.39401055
82IKBKE0.38829387
83RPS6KA60.37304394
84PRKG10.36666788
85YES10.36434083
86MAPK10.36170545
87CHEK10.35796210
88MARK20.35504160
89AKT30.34604139
90CDK20.34032946
91MAPK70.33973071
92TNK20.33240605
93PINK10.33169709
94CAMK10.30530183
95CAMK1D0.30347029
96SGK10.29676460
97IRAK30.29080595
98PASK0.28234226
99MAP3K50.28141039
100MAP3K80.27942685

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.07937071
2Allograft rejection_Homo sapiens_hsa053303.37074427
3Autoimmune thyroid disease_Homo sapiens_hsa053203.19039049
4Graft-versus-host disease_Homo sapiens_hsa053323.10502503
5Type I diabetes mellitus_Homo sapiens_hsa049402.80894714
6Asthma_Homo sapiens_hsa053102.60031534
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.59962847
8Leishmaniasis_Homo sapiens_hsa051402.45473722
9Primary immunodeficiency_Homo sapiens_hsa053402.43211485
10Antigen processing and presentation_Homo sapiens_hsa046122.34261205
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27743327
12Dorso-ventral axis formation_Homo sapiens_hsa043202.25712139
13B cell receptor signaling pathway_Homo sapiens_hsa046622.12440929
14Influenza A_Homo sapiens_hsa051641.96342941
15Herpes simplex infection_Homo sapiens_hsa051681.85285194
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75666464
17Osteoclast differentiation_Homo sapiens_hsa043801.74380803
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72114651
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.61936055
20Staphylococcus aureus infection_Homo sapiens_hsa051501.60588661
21Viral myocarditis_Homo sapiens_hsa054161.58958974
22Rheumatoid arthritis_Homo sapiens_hsa053231.53347709
23RNA transport_Homo sapiens_hsa030131.53328525
24Olfactory transduction_Homo sapiens_hsa047401.51314562
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.48205588
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46673570
27Hematopoietic cell lineage_Homo sapiens_hsa046401.42104837
28Tuberculosis_Homo sapiens_hsa051521.38002907
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36977807
30T cell receptor signaling pathway_Homo sapiens_hsa046601.34988846
31Other glycan degradation_Homo sapiens_hsa005111.30781163
32Toxoplasmosis_Homo sapiens_hsa051451.30599416
33Measles_Homo sapiens_hsa051621.27043045
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.25584036
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23168898
36Acute myeloid leukemia_Homo sapiens_hsa052211.13236652
37Type II diabetes mellitus_Homo sapiens_hsa049301.12757584
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08862873
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.06854985
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05716295
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04279030
42Chemokine signaling pathway_Homo sapiens_hsa040621.02508194
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01446300
44Regulation of autophagy_Homo sapiens_hsa041400.99451590
45Epstein-Barr virus infection_Homo sapiens_hsa051690.97252357
46Base excision repair_Homo sapiens_hsa034100.96754746
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.93908864
48Fanconi anemia pathway_Homo sapiens_hsa034600.93326350
49Legionellosis_Homo sapiens_hsa051340.90569858
50TNF signaling pathway_Homo sapiens_hsa046680.88424782
51mRNA surveillance pathway_Homo sapiens_hsa030150.87038291
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84374957
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84126175
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83477284
55African trypanosomiasis_Homo sapiens_hsa051430.80457314
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80429076
57Fatty acid degradation_Homo sapiens_hsa000710.79428796
58Endocytosis_Homo sapiens_hsa041440.78375525
59Non-homologous end-joining_Homo sapiens_hsa034500.74424007
60Hepatitis B_Homo sapiens_hsa051610.74373650
61VEGF signaling pathway_Homo sapiens_hsa043700.69895051
62Inositol phosphate metabolism_Homo sapiens_hsa005620.68915050
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67482837
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67457434
65Basal transcription factors_Homo sapiens_hsa030220.65604416
66HTLV-I infection_Homo sapiens_hsa051660.65008579
67Lysosome_Homo sapiens_hsa041420.62460743
68Phagosome_Homo sapiens_hsa041450.61553661
69Fatty acid metabolism_Homo sapiens_hsa012120.61447021
70Prolactin signaling pathway_Homo sapiens_hsa049170.58866068
71mTOR signaling pathway_Homo sapiens_hsa041500.58291911
72MAPK signaling pathway_Homo sapiens_hsa040100.54145652
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53334822
74Butanoate metabolism_Homo sapiens_hsa006500.53259217
75Viral carcinogenesis_Homo sapiens_hsa052030.50244046
76Malaria_Homo sapiens_hsa051440.49427955
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47947625
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.47904047
79Shigellosis_Homo sapiens_hsa051310.46114889
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45309179
81Nucleotide excision repair_Homo sapiens_hsa034200.43416164
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43186582
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42959405
84Non-small cell lung cancer_Homo sapiens_hsa052230.38926367
85Platelet activation_Homo sapiens_hsa046110.38072540
86Homologous recombination_Homo sapiens_hsa034400.37932842
87Chronic myeloid leukemia_Homo sapiens_hsa052200.37308641
88Pancreatic cancer_Homo sapiens_hsa052120.35406188
89Pertussis_Homo sapiens_hsa051330.35360049
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35248830
91Salmonella infection_Homo sapiens_hsa051320.33809719
92Sulfur relay system_Homo sapiens_hsa041220.31161565
93Cell cycle_Homo sapiens_hsa041100.29868900
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27831160
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.25833762
96Oocyte meiosis_Homo sapiens_hsa041140.24920757
97Hepatitis C_Homo sapiens_hsa051600.24848646
98ErbB signaling pathway_Homo sapiens_hsa040120.23750507
99Ribosome_Homo sapiens_hsa030100.22846861
100Pyrimidine metabolism_Homo sapiens_hsa002400.22174823

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