ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chromosome condensation (GO:0030261)	9.27929529
2	DNA packaging (GO:0006323)	8.91045798
3	sperm capacitation (GO:0048240)	8.69379690
4	protein targeting to Golgi (GO:0000042)	8.13776070
5	microtubule depolymerization (GO:0007019)	8.04426799
6	plasma membrane fusion (GO:0045026)	7.83408039
7	establishment of protein localization to Golgi (GO:0072600)	7.76886471
8	retrograde transport, vesicle recycling within Golgi (GO:0000301)	7.61275846
9	spermatid nucleus differentiation (GO:0007289)	7.48292266
10	spermatid development (GO:0007286)	7.47659627
11	single strand break repair (GO:0000012)	7.40758992
12	protein polyglutamylation (GO:0018095)	7.19497577
13	microtubule polymerization or depolymerization (GO:0031109)	7.05900671
14	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.90830743
15	rRNA methylation (GO:0031167)	6.86528807
16	sperm-egg recognition (GO:0035036)	6.74751175
17	response to pheromone (GO:0019236)	6.59347740
18	centriole replication (GO:0007099)	6.41702531
19	phosphatidylethanolamine metabolic process (GO:0046337)	6.38085515
20	multicellular organism reproduction (GO:0032504)	6.33317904
21	spermatogenesis (GO:0007283)	6.15011214
22	male gamete generation (GO:0048232)	6.12923324
23	sexual reproduction (GO:0019953)	6.08672270
24	binding of sperm to zona pellucida (GO:0007339)	6.07012207
25	reproduction (GO:0000003)	6.04320996
26	negative regulation of inclusion body assembly (GO:0090084)	6.02988155
27	calcium ion-dependent exocytosis (GO:0017156)	5.96429375
28	protein localization to Golgi apparatus (GO:0034067)	5.71964658
29	centriole assembly (GO:0098534)	5.71633141
30	rRNA modification (GO:0000154)	5.63244812
31	gamete generation (GO:0007276)	5.61484577
32	axonemal dynein complex assembly (GO:0070286)	5.59043873
33	microtubule severing (GO:0051013)	5.58419805
34	cell-cell recognition (GO:0009988)	5.55223597
35	regulation of centriole replication (GO:0046599)	5.36510966
36	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	5.33635684
37	seminiferous tubule development (GO:0072520)	5.26538363
38	RNA destabilization (GO:0050779)	5.23171000
39	positive regulation of Rab GTPase activity (GO:0032851)	4.97402690
40	regulation of Rab GTPase activity (GO:0032313)	4.97402690
41	motile cilium assembly (GO:0044458)	4.79343950
42	single fertilization (GO:0007338)	4.75288570
43	regulation of cilium movement (GO:0003352)	4.62604589
44	cilium or flagellum-dependent cell motility (GO:0001539)	4.60751716
45	cell wall macromolecule catabolic process (GO:0016998)	4.60392091
46	multicellular organismal reproductive process (GO:0048609)	4.49597513
47	cell wall macromolecule metabolic process (GO:0044036)	4.36198144
48	regulation of inclusion body assembly (GO:0090083)	4.30470233
49	germ cell development (GO:0007281)	4.28528965
50	chromatin silencing (GO:0006342)	4.28087228
51	nucleus organization (GO:0006997)	4.22062989
52	fertilization (GO:0009566)	4.16626245
53	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.14620746
54	microtubule nucleation (GO:0007020)	4.12581105
55	regulation of transcription involved in cell fate commitment (GO:0060850)	4.01920575
56	glomerular visceral epithelial cell development (GO:0072015)	4.00113962
57	musculoskeletal movement (GO:0050881)	3.93438913
58	multicellular organismal movement (GO:0050879)	3.93438913
59	cellular ketone body metabolic process (GO:0046950)	3.93362133
60	nuclear pore complex assembly (GO:0051292)	3.88716169
61	epithelial cilium movement (GO:0003351)	3.80586653
62	glomerular epithelial cell development (GO:0072310)	3.75630867
63	regulation of T-helper 2 cell differentiation (GO:0045628)	3.71413681
64	glycerol ether metabolic process (GO:0006662)	3.58532145
65	negative regulation of Rho protein signal transduction (GO:0035024)	3.55454024
66	ketone body metabolic process (GO:1902224)	3.43688526
67	organic cation transport (GO:0015695)	3.42199676
68	membrane protein intracellular domain proteolysis (GO:0031293)	3.34135494
69	histone H3-K9 demethylation (GO:0033169)	3.31582723
70	cilium movement (GO:0003341)	3.30231507
71	ether metabolic process (GO:0018904)	3.28809187
72	homeostasis of number of cells within a tissue (GO:0048873)	3.24432364
73	protein-DNA complex disassembly (GO:0032986)	3.16739346
74	nucleosome disassembly (GO:0006337)	3.16739346
75	protein depolymerization (GO:0051261)	3.15569562
76	intra-Golgi vesicle-mediated transport (GO:0006891)	3.13968063
77	Golgi to endosome transport (GO:0006895)	3.08844084
78	regulation of ARF GTPase activity (GO:0032312)	3.06350296
79	regulation of interleukin-13 production (GO:0032656)	3.05964480
80	negative regulation of gene expression, epigenetic (GO:0045814)	3.04902256
81	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.02353194
82	regulation of microtubule-based movement (GO:0060632)	3.01720980
83	response to acidic pH (GO:0010447)	3.01172854
84	cerebral cortex neuron differentiation (GO:0021895)	2.98843061
85	polyamine biosynthetic process (GO:0006596)	2.98197821
86	ventricular system development (GO:0021591)	2.97154029
87	peptidyl-threonine dephosphorylation (GO:0035970)	2.94723258
88	cellular response to pH (GO:0071467)	2.94173279
89	pore complex assembly (GO:0046931)	2.90841759
90	DNA conformation change (GO:0071103)	2.90813098
91	multicellular organismal development (GO:0007275)	2.89076005
92	nuclear pore organization (GO:0006999)	2.84420562
93	negative regulation of histone methylation (GO:0031061)	2.82490904
94	RNA localization (GO:0006403)	2.81469722
95	actin filament capping (GO:0051693)	2.79677246
96	receptor recycling (GO:0001881)	2.71979926
97	centrosome duplication (GO:0051298)	2.67678505
98	sperm motility (GO:0030317)	11.4873095
99	acrosome reaction (GO:0007340)	10.8222443
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.4301564

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.59196596
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.58767861
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.55419026
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35644575
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.35644575
6	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.31602500
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.27909373
8	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.20926363
9	GATA1_19941826_ChIP-Seq_K562_Human	2.08141721
10	RAC3_21632823_ChIP-Seq_H3396_Human	1.98659910
11	CBP_20019798_ChIP-Seq_JUKART_Human	1.97367602
12	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.97367602
13	BCL6_27268052_Chip-Seq_Bcells_Human	1.85328747
14	ERA_21632823_ChIP-Seq_H3396_Human	1.84058494
15	DROSHA_22980978_ChIP-Seq_HELA_Human	1.82757436
16	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.81899419
17	NANOG_20526341_ChIP-Seq_ESCs_Human	1.75838572
18	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.75697404
19	BCOR_27268052_Chip-Seq_Bcells_Human	1.74967293
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.73745044
21	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.72801260
22	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.72466819
23	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.68331502
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.67402442
25	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.66408905
26	SMC4_20622854_ChIP-Seq_HELA_Human	1.64239422
27	P68_20966046_ChIP-Seq_HELA_Human	1.63090885
28	LXR_22292898_ChIP-Seq_THP-1_Human	1.59744071
29	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.58875361
30	FUS_26573619_Chip-Seq_HEK293_Human	1.58389219
31	RUNX_20019798_ChIP-Seq_JUKART_Human	1.57027699
32	CTCF_27219007_Chip-Seq_Bcells_Human	1.56084108
33	TAF2_19829295_ChIP-Seq_ESCs_Human	1.56002159
34	E2F1_20622854_ChIP-Seq_HELA_Human	1.52749954
35	PHF8_20622854_ChIP-Seq_HELA_Human	1.52054652
36	MYC_19829295_ChIP-Seq_ESCs_Human	1.51367559
37	EZH2_22144423_ChIP-Seq_EOC_Human	1.50680479
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.48931965
39	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.48351916
40	CTCF_20526341_ChIP-Seq_ESCs_Human	1.46193533
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45495850
42	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.45315332
43	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.43529012
44	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.43372223
45	TP63_22573176_ChIP-Seq_HFKS_Human	1.43266665
46	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.42856126
47	RBPJ_21746931_ChIP-Seq_IB4_Human	1.42471530
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.42306066
49	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.42082539
50	OCT4_20526341_ChIP-Seq_ESCs_Human	1.41559840
51	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.40840247
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38559856
53	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.37909384
54	P300_27268052_Chip-Seq_Bcells_Human	1.37662795
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34790471
56	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34454532
57	CEBPB_22108803_ChIP-Seq_LS180_Human	1.34155456
58	ETV1_20927104_ChIP-Seq_GIST48_Human	1.32914492
59	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.32556668
60	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.32533523
61	ERG_20517297_ChIP-Seq_VCAP_Human	1.31858613
62	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.28402001
63	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.26069219
64	SA1_27219007_Chip-Seq_Bcells_Human	1.25765182
65	SPI1_23127762_ChIP-Seq_K562_Human	1.23282339
66	NFYB_21822215_ChIP-Seq_K562_Human	1.23227874
67	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.23109700
68	GATA2_19941826_ChIP-Seq_K562_Human	1.22201015
69	VDR_24787735_ChIP-Seq_THP-1_Human	1.18901741
70	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.18533618
71	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.18347313
72	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.17788817
73	SMRT_27268052_Chip-Seq_Bcells_Human	1.17585790
74	TBL1_22424771_ChIP-Seq_293T_Human	1.17327975
75	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.16619429
76	SPI1_20517297_ChIP-Seq_HL60_Human	1.14671611
77	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.14149071
78	PHF8_20622853_ChIP-Seq_HELA_Human	1.13647026
79	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.12457367
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10929936
81	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.09820572
82	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.06548894
83	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.05641951
84	AR_25329375_ChIP-Seq_VCAP_Human	1.05607697
85	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04746673
86	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.04586558
87	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.04539017
88	OCT4_19829295_ChIP-Seq_ESCs_Human	1.02837198
89	KLF4_19829295_ChIP-Seq_ESCs_Human	1.02440864
90	NFYA_21822215_ChIP-Seq_K562_Human	1.02217467
91	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.01895601
92	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.00881948
93	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.00114938
94	P53_21459846_ChIP-Seq_SAOS-2_Human	0.98682062
95	KLF5_25053715_ChIP-Seq_YYC3_Human	0.98347483
96	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.98125863
97	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98045638
98	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.97119826
99	GF1_26923725_Chip-Seq_HPCs_Mouse	0.94313519
100	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.93777527

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	6.04271632
2	MP0005377_hearing/vestibular/ear_phenot	6.04271632
3	MP0005670_abnormal_white_adipose	4.21978782
4	MP0003698_abnormal_male_reproductive	4.16066702
5	MP0001929_abnormal_gametogenesis	3.67217329
6	MP0001348_abnormal_lacrimal_gland	3.31991243
7	MP0005451_abnormal_body_composition	2.88307378
8	MP0002132_abnormal_respiratory_system	2.41146334
9	MP0002161_abnormal_fertility/fecundity	2.28859386
10	MP0005083_abnormal_biliary_tract	2.08042555
11	MP0003646_muscle_fatigue	2.06647599
12	MP0005310_abnormal_salivary_gland	2.06535360
13	MP0000678_abnormal_parathyroid_gland	2.03482135
14	MP0005410_abnormal_fertilization	11.3370459
15	MP0003879_abnormal_hair_cell	1.73468018
16	MP0003011_delayed_dark_adaptation	1.70052658
17	MP0003718_maternal_effect	1.69971931
18	MP0001485_abnormal_pinna_reflex	1.62488932
19	MP0002210_abnormal_sex_determination	1.58299151
20	MP0005379_endocrine/exocrine_gland_phen	1.54271749
21	MP0003656_abnormal_erythrocyte_physiolo	1.52670131
22	MP0004510_myositis	1.42205111
23	MP0001545_abnormal_hematopoietic_system	1.42095783
24	MP0005397_hematopoietic_system_phenotyp	1.42095783
25	MP0001486_abnormal_startle_reflex	1.40679010
26	MP0004742_abnormal_vestibular_system	1.31134737
27	MP0001145_abnormal_male_reproductive	1.28809131
28	MP0005423_abnormal_somatic_nervous	1.22795566
29	MP0000653_abnormal_sex_gland	1.20350724
30	MP0002138_abnormal_hepatobiliary_system	1.18201415
31	MP0009278_abnormal_bone_marrow	1.11950503
32	MP0009115_abnormal_fat_cell	1.11856834
33	MP0004859_abnormal_synaptic_plasticity	1.11363932
34	MP0002282_abnormal_trachea_morphology	1.07745795
35	MP0001765_abnormal_ion_homeostasis	1.06194183
36	MP0002249_abnormal_larynx_morphology	1.04002021
37	MP0005666_abnormal_adipose_tissue	0.97998472
38	MP0001963_abnormal_hearing_physiology	0.97895871
39	MP0002822_catalepsy	0.94843739
40	MP0005248_abnormal_Harderian_gland	0.91921050
41	MP0003436_decreased_susceptibility_to	0.91515163
42	MP0005636_abnormal_mineral_homeostasis	0.89371850
43	MP0008995_early_reproductive_senescence	0.88876624
44	MP0003172_abnormal_lysosome_physiology	0.88650001
45	MP0009764_decreased_sensitivity_to	0.85952379
46	MP0002127_abnormal_cardiovascular_syste	0.85710013
47	MP0009053_abnormal_anal_canal	0.83622967
48	MP0002229_neurodegeneration	0.83192985
49	MP0001835_abnormal_antigen_presentation	0.80039310
50	MP0009697_abnormal_copulation	0.79678834
51	MP0005167_abnormal_blood-brain_barrier	0.77737244
52	MP0005395_other_phenotype	0.76611665
53	MP0004147_increased_porphyrin_level	0.76033075
54	MP0002419_abnormal_innate_immunity	0.74254512
55	MP0003303_peritoneal_inflammation	0.70665807
56	MP0009785_altered_susceptibility_to	0.70189188
57	MP0002735_abnormal_chemical_nociception	0.68993731
58	MP0005025_abnormal_response_to	0.67807096
59	MP0003724_increased_susceptibility_to	0.66275652
60	MP0000534_abnormal_ureter_morphology	0.64525108
61	MP0004233_abnormal_muscle_weight	0.64525042
62	MP0000026_abnormal_inner_ear	0.64492184
63	MP0005375_adipose_tissue_phenotype	0.62679080
64	MP0008569_lethality_at_weaning	0.62382117
65	MP0000955_abnormal_spinal_cord	0.62213958
66	MP0002067_abnormal_sensory_capabilities	0.59320559
67	MP0000681_abnormal_thyroid_gland	0.58951225
68	MP0001968_abnormal_touch/_nociception	0.58253820
69	MP0008877_abnormal_DNA_methylation	0.57871867
70	MP0005535_abnormal_body_temperature	0.56676460
71	MP0005253_abnormal_eye_physiology	0.56660132
72	MP0002653_abnormal_ependyma_morphology	0.54742485
73	MP0002234_abnormal_pharynx_morphology	0.54629720
74	MP0003077_abnormal_cell_cycle	0.53897083
75	MP0001533_abnormal_skeleton_physiology	0.53382087
76	MP0005551_abnormal_eye_electrophysiolog	0.51950571
77	MP0002723_abnormal_immune_serum	0.50390781
78	MP0010307_abnormal_tumor_latency	0.46968521
79	MP0002733_abnormal_thermal_nociception	0.44028955
80	MP0004085_abnormal_heartbeat	0.43202662
81	MP0003828_pulmonary_edema	0.42943943
82	MP0000249_abnormal_blood_vessel	0.42096612
83	MP0003329_amyloid_beta_deposits	0.41364908
84	MP0002928_abnormal_bile_duct	0.41074273
85	MP0003631_nervous_system_phenotype	0.40857539
86	MP0002398_abnormal_bone_marrow	0.40289366
87	MP0008874_decreased_physiological_sensi	0.40151459
88	MP0004484_altered_response_of	0.39789639
89	MP0005000_abnormal_immune_tolerance	0.39716543
90	MP0002722_abnormal_immune_system	0.39627957
91	MP0001873_stomach_inflammation	0.38543271
92	MP0001905_abnormal_dopamine_level	0.38471229
93	MP0000685_abnormal_immune_system	0.38405184
94	MP0009765_abnormal_xenobiotic_induced	0.37986590
95	MP0001800_abnormal_humoral_immune	0.37522418
96	MP0008469_abnormal_protein_level	0.36290581
97	MP0000703_abnormal_thymus_morphology	0.35894617
98	MP0002452_abnormal_antigen_presenting	0.35714617
99	MP0002405_respiratory_system_inflammati	0.35462659
100	MP0004036_abnormal_muscle_relaxation	0.35228524

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.60757106
2	Absent/shortened dynein arms (HP:0200106)	5.86773600
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.86773600
4	Asymmetric septal hypertrophy (HP:0001670)	5.84394026
5	Tubulointerstitial nephritis (HP:0001970)	5.75024532
6	Chronic hepatic failure (HP:0100626)	5.27102411
7	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	5.21145409
8	Nasal polyposis (HP:0100582)	4.90072201
9	Resting tremor (HP:0002322)	4.54953681
10	Male infertility (HP:0003251)	4.41381870
11	Cone-rod dystrophy (HP:0000548)	4.38333038
12	Hyperkalemia (HP:0002153)	4.33393504
13	Attenuation of retinal blood vessels (HP:0007843)	4.23419301
14	Bony spicule pigmentary retinopathy (HP:0007737)	4.20614657
15	Abnormal ciliary motility (HP:0012262)	4.17436035
16	Aplasia/Hypoplasia of the earlobes (HP:0009906)	4.12952181
17	Abnormal respiratory motile cilium physiology (HP:0012261)	4.10889625
18	Abnormality of the nasal mucosa (HP:0000433)	4.01272427
19	Abnormal respiratory motile cilium morphology (HP:0005938)	3.81735883
20	Abnormal respiratory epithelium morphology (HP:0012253)	3.81735883
21	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.81632500
22	Abnormality of macular pigmentation (HP:0008002)	3.77259521
23	Infertility (HP:0000789)	3.73144574
24	Hypoalphalipoproteinemia (HP:0003233)	3.53409882
25	Menstrual irregularities (HP:0000858)	3.50793094
26	Postural instability (HP:0002172)	3.47581770
27	Hypoplasia of the thymus (HP:0000778)	3.44542951
28	Hypochromic microcytic anemia (HP:0004840)	3.40572545
29	Bell-shaped thorax (HP:0001591)	3.35104329
30	Impulsivity (HP:0100710)	3.33822772
31	Progressive sensorineural hearing impairment (HP:0000408)	3.29946545
32	Abnormality of dental color (HP:0011073)	3.28365451
33	Amelogenesis imperfecta (HP:0000705)	3.21504794
34	Truncal obesity (HP:0001956)	3.12717427
35	Abnormal rod and cone electroretinograms (HP:0008323)	3.10421709
36	Potter facies (HP:0002009)	3.09392248
37	Facial shape deformation (HP:0011334)	3.09392248
38	Osteomalacia (HP:0002749)	3.01787676
39	Enlarged epiphyses (HP:0010580)	2.92014586
40	Poikilocytosis (HP:0004447)	2.86796112
41	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.81744780
42	Portal hypertension (HP:0001409)	2.79479043
43	Renovascular hypertension (HP:0100817)	2.76736635
44	Abnormal spermatogenesis (HP:0008669)	2.74259572
45	Progressive cerebellar ataxia (HP:0002073)	2.69145260
46	Hypoplastic ischia (HP:0003175)	2.68802134
47	Gastrointestinal infarctions (HP:0005244)	2.67334904
48	Gingivitis (HP:0000230)	2.66168548
49	Insulin-resistant diabetes mellitus (HP:0000831)	2.65977616
50	Abnormality of the hepatic vasculature (HP:0006707)	2.56867683
51	Abnormality of the costochondral junction (HP:0000919)	2.55656315
52	Tubulointerstitial abnormality (HP:0001969)	2.53444151
53	Stage 5 chronic kidney disease (HP:0003774)	2.52627498
54	Abnormality of the ischium (HP:0003174)	2.42288850
55	Recurrent pneumonia (HP:0006532)	2.36845021
56	Subcapsular cataract (HP:0000523)	2.35593127
57	Abnormal urine output (HP:0012590)	2.29533904
58	Azoospermia (HP:0000027)	2.29192670
59	Reticulocytosis (HP:0001923)	2.29170570
60	Abnormality of potassium homeostasis (HP:0011042)	2.26245288
61	Abnormality of the aortic arch (HP:0012303)	2.23682981
62	Rhinitis (HP:0012384)	2.22650708
63	Progressive hearing impairment (HP:0001730)	2.22361652
64	Ventricular tachycardia (HP:0004756)	2.21331188
65	Increased purine levels (HP:0004368)	2.14623084
66	Hyperuricemia (HP:0002149)	2.14623084
67	Generalized aminoaciduria (HP:0002909)	2.14594919
68	Hyponatremia (HP:0002902)	2.14406469
69	Nephronophthisis (HP:0000090)	2.12441264
70	Hypochromic anemia (HP:0001931)	2.12338392
71	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.03919997
72	Focal segmental glomerulosclerosis (HP:0000097)	2.03368685
73	Polydipsia (HP:0001959)	2.03310925
74	Abnormal drinking behavior (HP:0030082)	2.03310925
75	Intellectual disability, moderate (HP:0002342)	1.99188455
76	Peritonitis (HP:0002586)	1.97632494
77	Unilateral renal agenesis (HP:0000122)	1.96341827
78	Widely patent fontanelles and sutures (HP:0004492)	1.96018167
79	Abnormality of renal excretion (HP:0011036)	1.95149159
80	Hypoparathyroidism (HP:0000829)	1.91326846
81	Double outlet right ventricle (HP:0001719)	1.85507558
82	Congenital malformation of the right heart (HP:0011723)	1.85507558
83	Peripheral hypomyelination (HP:0007182)	1.85474369
84	Sandal gap (HP:0001852)	1.84371545
85	Bronchiectasis (HP:0002110)	1.82747715
86	Chronic bronchitis (HP:0004469)	1.82659453
87	Flattened epiphyses (HP:0003071)	1.81894997
88	Abnormality of the renal medulla (HP:0100957)	1.80019680
89	Polyuria (HP:0000103)	1.79147600
90	Polycythemia (HP:0001901)	1.78857676
91	Hypertriglyceridemia (HP:0002155)	1.76854094
92	Cholelithiasis (HP:0001081)	1.76837491
93	Hypophosphatemic rickets (HP:0004912)	1.76511543
94	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.76257626
95	Bowel incontinence (HP:0002607)	1.75889212
96	Chronic obstructive pulmonary disease (HP:0006510)	1.72523021
97	Obstructive lung disease (HP:0006536)	1.72523021
98	Tetany (HP:0001281)	1.71915291
99	Abnormality of the parathyroid morphology (HP:0011766)	1.70797083
100	Hypolipoproteinemia (HP:0010981)	1.67380509

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	9.37710811
2	TESK1	4.49959436
3	BRD4	4.11068690
4	INSRR	4.07290870
5	DDR2	3.36085500
6	PLK2	3.33238317
7	STK38	2.84723046
8	PNCK	2.69220862
9	CAMK1G	2.56494894
10	MAP4K2	2.25662500
11	PIK3CG	2.25352350
12	PRKD3	1.98994780
13	RIPK4	1.84810006
14	WNK1	1.81473518
15	CDK12	1.77571742
16	PDPK1	1.70760746
17	PDK1	1.69567014
18	STK38L	1.59983837
19	KSR2	1.55470462
20	MAP3K11	1.51504003
21	MAPK15	1.51455833
22	DYRK1B	1.48516735
23	PTK2B	1.40141889
24	NEK6	1.36796004
25	TYRO3	1.30141872
26	CAMK1D	1.22113782
27	SIK2	1.08524457
28	CDK7	1.06855896
29	BLK	0.96964945
30	MST1R	0.89773906
31	MAP3K1	0.83120485
32	BRAF	0.82073913
33	MAP3K2	0.81054044
34	PRKG2	0.80693364
35	AKT3	0.76083898
36	MAP3K8	0.74181758
37	JAK3	0.71698384
38	PRKAA2	0.67629832
39	RPS6KA2	0.65334505
40	MAP2K2	0.63140591
41	MARK2	0.57153021
42	RPS6KA1	0.56761519
43	GRK6	0.55046665
44	CAMK1	0.53894301
45	TNK2	0.52930586
46	RPS6KC1	0.51246170
47	RPS6KL1	0.51246170
48	SGK223	0.50663292
49	SGK494	0.50663292
50	PRKG1	0.49735436
51	JAK2	0.48869811
52	MAP2K3	0.48081841
53	UHMK1	0.44430229
54	RPS6KA6	0.43214072
55	DYRK3	0.42672131
56	CAMK4	0.42109054
57	SGK1	0.41703226
58	MAPK1	0.41647629
59	TESK2	0.40127212
60	CDK2	0.39298187
61	MAP3K9	0.39159203
62	MAP3K3	0.38604186
63	TAOK1	0.38430981
64	SGK2	0.37925096
65	PRKCZ	0.37145207
66	NTRK3	0.36844786
67	GSK3B	0.36058520
68	CDK3	0.35233098
69	CDK1	0.34820659
70	IRAK4	0.33657517
71	SGK3	0.33107468
72	SYK	0.33085585
73	MTOR	0.32095805
74	CSK	0.32076390
75	MAPK8	0.30554969
76	ROCK1	0.29882773
77	MAP4K1	0.29824433
78	BRSK1	0.28780288
79	CDK4	0.27932846
80	MAP3K7	0.25878592
81	TIE1	0.24931768
82	AKT1	0.22141471
83	HCK	0.21964204
84	MAPK10	0.20503101
85	LATS2	0.19277940
86	MAP2K1	0.18418961
87	ERN1	0.18031464
88	PRKCB	0.17942531
89	CHEK1	0.17585829
90	MAPK14	0.17286305
91	MARK3	0.17238625
92	ICK	0.16350661
93	ZAP70	0.15877896
94	MAPK11	0.14798125
95	IKBKB	0.13437699
96	BRSK2	0.10630802
97	MAP3K13	0.10373331
98	LYN	0.10353331
99	KIT	0.09210033
100	BTK	0.08755401

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	6.25212034
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.99279569
3	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.73522892
4	Olfactory transduction_Homo sapiens_hsa04740	3.39201662
5	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.17425306
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.85012091
7	Type II diabetes mellitus_Homo sapiens_hsa04930	1.82569933
8	Allograft rejection_Homo sapiens_hsa05330	1.73975166
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.68098976
10	Antigen processing and presentation_Homo sapiens_hsa04612	1.65739836
11	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.65649096
12	Type I diabetes mellitus_Homo sapiens_hsa04940	1.63263172
13	Graft-versus-host disease_Homo sapiens_hsa05332	1.62847868
14	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.61895275
15	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.57213680
16	Influenza A_Homo sapiens_hsa05164	1.46515734
17	Acute myeloid leukemia_Homo sapiens_hsa05221	1.41889616
18	RNA transport_Homo sapiens_hsa03013	1.36528261
19	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.29498498
20	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.29391896
21	Butanoate metabolism_Homo sapiens_hsa00650	1.27639648
22	Endocytosis_Homo sapiens_hsa04144	1.26013005
23	Viral myocarditis_Homo sapiens_hsa05416	1.22745744
24	Taste transduction_Homo sapiens_hsa04742	1.22156283
25	VEGF signaling pathway_Homo sapiens_hsa04370	1.15014275
26	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.14865258
27	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.12604196
28	Fatty acid metabolism_Homo sapiens_hsa01212	1.12529808
29	Fatty acid degradation_Homo sapiens_hsa00071	1.11001813
30	Osteoclast differentiation_Homo sapiens_hsa04380	1.07985519
31	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.03121789
32	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.00223791
33	Leishmaniasis_Homo sapiens_hsa05140	0.98536191
34	Malaria_Homo sapiens_hsa05144	0.96891877
35	Phenylalanine metabolism_Homo sapiens_hsa00360	0.96758434
36	ABC transporters_Homo sapiens_hsa02010	0.95366552
37	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.95120982
38	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.95104905
39	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.93654648
40	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.91701747
41	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.91210098
42	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.87496275
43	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.86047145
44	Herpes simplex infection_Homo sapiens_hsa05168	0.83688568
45	Non-small cell lung cancer_Homo sapiens_hsa05223	0.79426909
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78976028
47	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.78587052
48	Chemokine signaling pathway_Homo sapiens_hsa04062	0.72022250
49	cAMP signaling pathway_Homo sapiens_hsa04024	0.71550987
50	Estrogen signaling pathway_Homo sapiens_hsa04915	0.70479862
51	Measles_Homo sapiens_hsa05162	0.70427420
52	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.69651213
53	Legionellosis_Homo sapiens_hsa05134	0.67795369
54	Prolactin signaling pathway_Homo sapiens_hsa04917	0.67318917
55	Morphine addiction_Homo sapiens_hsa05032	0.66803201
56	Toxoplasmosis_Homo sapiens_hsa05145	0.66122000
57	PPAR signaling pathway_Homo sapiens_hsa03320	0.65711957
58	Long-term potentiation_Homo sapiens_hsa04720	0.65687452
59	African trypanosomiasis_Homo sapiens_hsa05143	0.64247997
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.62607219
61	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.62297967
62	Protein digestion and absorption_Homo sapiens_hsa04974	0.61317155
63	Tuberculosis_Homo sapiens_hsa05152	0.60550019
64	MAPK signaling pathway_Homo sapiens_hsa04010	0.59326893
65	Viral carcinogenesis_Homo sapiens_hsa05203	0.58708575
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.58393049
67	Salivary secretion_Homo sapiens_hsa04970	0.56807910
68	Oocyte meiosis_Homo sapiens_hsa04114	0.55960039
69	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.54600308
70	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.53748681
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53136148
72	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.52964081
73	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.52325004
74	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.51139743
75	mTOR signaling pathway_Homo sapiens_hsa04150	0.48359924
76	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.47515954
77	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.46932786
78	Phototransduction_Homo sapiens_hsa04744	0.43280713
79	Choline metabolism in cancer_Homo sapiens_hsa05231	0.42594334
80	Arginine biosynthesis_Homo sapiens_hsa00220	0.41500261
81	Circadian entrainment_Homo sapiens_hsa04713	0.40036864
82	Hepatitis B_Homo sapiens_hsa05161	0.38057223
83	Gastric acid secretion_Homo sapiens_hsa04971	0.36759181
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.35407850
85	Cholinergic synapse_Homo sapiens_hsa04725	0.35232059
86	FoxO signaling pathway_Homo sapiens_hsa04068	0.34053791
87	Prostate cancer_Homo sapiens_hsa05215	0.33870608
88	Phagosome_Homo sapiens_hsa04145	0.33709740
89	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.32780324
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.32458487
91	Renin-angiotensin system_Homo sapiens_hsa04614	0.31819899
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.31711394
93	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.30235576
94	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.29541607
95	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.28937863
96	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.28843802
97	Renin secretion_Homo sapiens_hsa04924	0.28443385
98	mRNA surveillance pathway_Homo sapiens_hsa03015	0.28419552
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.28313650
100	Serotonergic synapse_Homo sapiens_hsa04726	0.28259123

C7ORF34

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »