C7ORF43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.03387537
2negative regulation of cell killing (GO:0031342)6.03387537
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.63116014
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.43142875
5positive regulation of gamma-delta T cell activation (GO:0046645)5.32958282
6antigen processing and presentation of endogenous antigen (GO:0019883)5.19346282
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.16982335
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.16982335
9modulation by symbiont of host immune response (GO:0052553)5.16982335
10positive regulation by symbiont of host defense response (GO:0052509)5.16982335
11modulation by symbiont of host defense response (GO:0052031)5.16982335
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.16982335
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.99063753
14detection of other organism (GO:0098543)4.66208023
15detection of bacterium (GO:0016045)4.57185838
16neutrophil activation involved in immune response (GO:0002283)4.52694485
17macrophage activation involved in immune response (GO:0002281)4.48650353
18leukocyte aggregation (GO:0070486)4.41549258
19response to peptidoglycan (GO:0032494)4.36872586
20negative regulation of erythrocyte differentiation (GO:0045647)4.29777556
21regulation of B cell receptor signaling pathway (GO:0050855)4.06483322
22detection of external biotic stimulus (GO:0098581)3.97886153
23regulation of gamma-delta T cell activation (GO:0046643)3.94407877
24regulation of interferon-beta biosynthetic process (GO:0045357)3.82392512
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.81671917
26cellular extravasation (GO:0045123)3.74941942
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.73009136
28negative regulation of interleukin-12 production (GO:0032695)3.72656782
29detection of molecule of bacterial origin (GO:0032490)3.68269235
30regulation of gamma-delta T cell differentiation (GO:0045586)3.54478436
31response to interleukin-15 (GO:0070672)3.48263305
32negative regulation of leukocyte mediated immunity (GO:0002704)3.47890691
33respiratory burst (GO:0045730)3.46725699
34neutrophil activation (GO:0042119)3.45875165
35regulation of mast cell degranulation (GO:0043304)3.45325423
36immunoglobulin mediated immune response (GO:0016064)3.44484119
37detection of biotic stimulus (GO:0009595)3.43489903
38positive thymic T cell selection (GO:0045059)3.42610068
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.40188416
40response to host immune response (GO:0052572)3.40188416
41response to muramyl dipeptide (GO:0032495)3.39741786
42positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.38193046
43negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.33322251
44regulation of leukocyte degranulation (GO:0043300)3.32964612
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.32665983
46B cell receptor signaling pathway (GO:0050853)3.32457737
47regulation of myeloid leukocyte mediated immunity (GO:0002886)3.32418281
48granulocyte activation (GO:0036230)3.27368344
49antigen processing and presentation via MHC class Ib (GO:0002475)3.26700824
50germinal center formation (GO:0002467)3.25835250
51response to host (GO:0075136)3.25306660
52response to host defenses (GO:0052200)3.25306660
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.25306660
54cellular response to type I interferon (GO:0071357)3.23189910
55type I interferon signaling pathway (GO:0060337)3.23189910
56response to type I interferon (GO:0034340)3.22493323
57myeloid cell activation involved in immune response (GO:0002275)3.22040497
58regulation of T-helper 2 cell differentiation (GO:0045628)3.21028218
59negative thymic T cell selection (GO:0045060)3.17759367
60leukocyte migration involved in inflammatory response (GO:0002523)3.15797905
61negative regulation of T cell mediated immunity (GO:0002710)3.13753161
62regulation of T cell tolerance induction (GO:0002664)3.12749320
63thymic T cell selection (GO:0045061)3.11840335
64mannose metabolic process (GO:0006013)3.11163787
65macrophage activation (GO:0042116)3.08681250
66regulation of mast cell activation involved in immune response (GO:0033006)3.08026538
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.08001098
68T cell selection (GO:0045058)3.06021637
69negative T cell selection (GO:0043383)3.04112522
70NIK/NF-kappaB signaling (GO:0038061)3.04040542
71cellular response to interleukin-15 (GO:0071350)3.01659478
72production of molecular mediator involved in inflammatory response (GO:0002532)2.98693031
73negative regulation of phagocytosis (GO:0050765)2.98349670
74lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97273987
75regulation of regulated secretory pathway (GO:1903305)2.93141818
76positive regulation of Cdc42 GTPase activity (GO:0043089)2.88054065
77tolerance induction (GO:0002507)2.87822761
78negative regulation of innate immune response (GO:0045824)2.87440155
79regulation of tolerance induction (GO:0002643)2.85788405
80positive T cell selection (GO:0043368)2.83801377
81microglial cell activation (GO:0001774)2.82830880
82defense response to protozoan (GO:0042832)2.82038471
83regulation of B cell differentiation (GO:0045577)2.81616461
84interferon-gamma-mediated signaling pathway (GO:0060333)2.81074922
85positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80459768
86negative regulation of interleukin-6 production (GO:0032715)2.80053103
87regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76668364
88positive regulation of B cell differentiation (GO:0045579)2.75600603
89positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.75143756
90negative regulation of type 2 immune response (GO:0002829)2.74969827
91negative regulation of toll-like receptor signaling pathway (GO:0034122)2.74365089
92positive regulation of mast cell activation (GO:0033005)2.71872201
93negative regulation of cytokine production involved in immune response (GO:0002719)2.70780378
94leukocyte degranulation (GO:0043299)2.70194099
95neutrophil mediated immunity (GO:0002446)2.69648000
96positive regulation of cellular amide metabolic process (GO:0034250)2.69505252
97regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.69199666
98regulation of natural killer cell mediated immunity (GO:0002715)2.69199666
99T cell migration (GO:0072678)2.67340415
100regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.66872525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.54489106
2VDR_21846776_ChIP-Seq_THP-1_Human3.36361840
3MYC_22102868_ChIP-Seq_BL_Human2.94000655
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82677559
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.60845352
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.60425229
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.53816870
8VDR_24763502_ChIP-Seq_THP-1_Human2.49894692
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.47611056
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.47149901
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45383938
12TCF7_22412390_ChIP-Seq_EML_Mouse2.44663102
13LXR_22292898_ChIP-Seq_THP-1_Human2.40264218
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.37149546
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.36676272
16* MAF_26560356_Chip-Seq_TH1_Human2.34067006
17KDM2B_26808549_Chip-Seq_DND41_Human2.28966522
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28559079
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28034007
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.24045770
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.21451498
22UTX_26944678_Chip-Seq_JUKART_Human2.11956199
23RUNX1_22412390_ChIP-Seq_EML_Mouse2.11929495
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.09480375
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08206857
26* SPI1_23127762_ChIP-Seq_K562_Human1.99882226
27MAF_26560356_Chip-Seq_TH2_Human1.99660126
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.99252576
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97091850
30* SPI1_23547873_ChIP-Seq_NB4_Human1.97079895
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96165342
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.95515489
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91263354
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89943332
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88277420
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88194124
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.86119214
38RACK7_27058665_Chip-Seq_MCF-7_Human1.75487824
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74900927
40RUNX_20019798_ChIP-Seq_JUKART_Human1.69646083
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68622816
42SCL_19346495_ChIP-Seq_HPC-7_Human1.67898582
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66564639
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65959457
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63301149
46MYB_26560356_Chip-Seq_TH1_Human1.57451824
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.55823863
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54808099
49MYB_26560356_Chip-Seq_TH2_Human1.54801712
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53478365
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49336986
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.47413665
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47139201
54KDM2B_26808549_Chip-Seq_K562_Human1.42563854
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40884824
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40512466
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38991556
58P68_20966046_ChIP-Seq_HELA_Human1.38119822
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37423982
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37335171
61BCOR_27268052_Chip-Seq_Bcells_Human1.36006232
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35601636
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.34500682
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.30633985
65BCL6_27268052_Chip-Seq_Bcells_Human1.29724609
66PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28308543
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27753028
68NCOR1_26117541_ChIP-Seq_K562_Human1.27127421
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26433724
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23891826
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21470376
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21457202
73* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17873476
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17190420
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.16719254
76SMC4_20622854_ChIP-Seq_HELA_Human1.16268736
77GATA1_19941826_ChIP-Seq_K562_Human1.15934931
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15085446
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13633569
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10034596
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09967052
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.07569703
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07369305
84* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07054777
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06700986
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05718128
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04439052
88GATA3_27048872_Chip-Seq_THYMUS_Human1.04151732
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03833545
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03096647
91PU_27001747_Chip-Seq_BMDM_Mouse1.01772397
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01297501
93CREB1_26743006_Chip-Seq_LNCaP_Human1.00795712
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00688107
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00646741
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00106202
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98613028
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.97712212
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97414948
100PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94700398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.22482325
2MP0003724_increased_susceptibility_to3.84472890
3MP0003303_peritoneal_inflammation3.71044656
4MP0001835_abnormal_antigen_presentation3.08831224
5MP0002419_abnormal_innate_immunity2.80568572
6MP0005025_abnormal_response_to2.63773021
7MP0005000_abnormal_immune_tolerance2.63219468
8MP0005387_immune_system_phenotype2.62005628
9MP0001790_abnormal_immune_system2.62005628
10MP0001800_abnormal_humoral_immune2.60964779
11MP0000685_abnormal_immune_system2.58919870
12MP0003300_gastrointestinal_ulcer2.55759444
13MP0003172_abnormal_lysosome_physiology2.53022858
14MP0005671_abnormal_response_to2.45688386
15MP0008260_abnormal_autophagy2.45213795
16MP0003191_abnormal_cellular_cholesterol2.39802082
17MP0003763_abnormal_thymus_physiology2.38939666
18MP0009785_altered_susceptibility_to2.36146230
19MP0002723_abnormal_immune_serum2.35121709
20MP0006082_CNS_inflammation2.31291204
21MP0002420_abnormal_adaptive_immunity2.29986415
22MP0001819_abnormal_immune_cell2.27908598
23MP0002452_abnormal_antigen_presenting2.25592325
24MP0005058_abnormal_lysosome_morphology2.20225161
25MP0005451_abnormal_body_composition2.15632677
26MP0001533_abnormal_skeleton_physiology2.03090009
27MP0004947_skin_inflammation1.98164002
28MP0003705_abnormal_hypodermis_morpholog1.96752517
29MP0009333_abnormal_splenocyte_physiolog1.89718539
30MP0010155_abnormal_intestine_physiology1.89680655
31MP0009278_abnormal_bone_marrow1.88942596
32MP0002148_abnormal_hypersensitivity_rea1.88081959
33MP0002398_abnormal_bone_marrow1.84594467
34MP0005464_abnormal_platelet_physiology1.83817057
35MP0002405_respiratory_system_inflammati1.83801285
36MP0002132_abnormal_respiratory_system1.79469908
37MP0000716_abnormal_immune_system1.78513176
38MP0002396_abnormal_hematopoietic_system1.74672056
39MP0003183_abnormal_peptide_metabolism1.69985866
40MP0004381_abnormal_hair_follicle1.65554566
41MP0001845_abnormal_inflammatory_respons1.62323245
42MP0000858_altered_metastatic_potential1.59526486
43MP0003866_abnormal_defecation1.57572978
44MP0002722_abnormal_immune_system1.49745282
45MP0000703_abnormal_thymus_morphology1.48724674
46MP0004510_myositis1.48165784
47MP0009840_abnormal_foam_cell1.45821278
48MP0002429_abnormal_blood_cell1.44434037
49MP0000689_abnormal_spleen_morphology1.42676119
50MP0005310_abnormal_salivary_gland1.39857359
51MP0001873_stomach_inflammation1.36854363
52MP0008469_abnormal_protein_level1.34769637
53MP0003828_pulmonary_edema1.34562746
54MP0002998_abnormal_bone_remodeling1.31369145
55MP0005076_abnormal_cell_differentiation1.24807950
56MP0005397_hematopoietic_system_phenotyp1.24332903
57MP0001545_abnormal_hematopoietic_system1.24332903
58MP0003075_altered_response_to1.22676848
59MP0001851_eye_inflammation1.22383731
60MP0000465_gastrointestinal_hemorrhage1.17643862
61MP0003453_abnormal_keratinocyte_physiol1.17042143
62MP0004883_abnormal_blood_vessel1.10138706
63MP0000490_abnormal_crypts_of1.06918066
64MP0001849_ear_inflammation1.06659707
65MP0003690_abnormal_glial_cell1.02512957
66MP0003091_abnormal_cell_migration0.99644662
67MP0005166_decreased_susceptibility_to0.99622278
68MP0009764_decreased_sensitivity_to0.98897633
69MP0002277_abnormal_respiratory_mucosa0.95527390
70MP0000604_amyloidosis0.94286122
71MP0003448_altered_tumor_morphology0.90230094
72MP0002933_joint_inflammation0.88750284
73MP0001853_heart_inflammation0.87625197
74MP0004185_abnormal_adipocyte_glucose0.87587638
75MP0004808_abnormal_hematopoietic_stem0.86950350
76MP0005164_abnormal_response_to0.86435452
77MP0005390_skeleton_phenotype0.86255668
78MP0001663_abnormal_digestive_system0.85321495
79MP0004858_abnormal_nervous_system0.84366769
80MP0008874_decreased_physiological_sensi0.83567549
81MP0003566_abnormal_cell_adhesion0.80868695
82MP0002166_altered_tumor_susceptibility0.80559290
83MP0005409_darkened_coat_color0.75827297
84MP0003045_fibrosis0.75607517
85MP0003329_amyloid_beta_deposits0.73622198
86MP0003795_abnormal_bone_structure0.70382871
87MP0008004_abnormal_stomach_pH0.68584245
88MP0000678_abnormal_parathyroid_gland0.67858959
89MP0000343_altered_response_to0.67116648
90MP0000015_abnormal_ear_pigmentation0.66381753
91MP0002138_abnormal_hepatobiliary_system0.66251272
92MP0000249_abnormal_blood_vessel0.63419412
93MP0009763_increased_sensitivity_to0.62769793
94MP0001348_abnormal_lacrimal_gland0.61642259
95MP0001986_abnormal_taste_sensitivity0.60955829
96MP0010234_abnormal_vibrissa_follicle0.60617094
97MP0001958_emphysema0.58029757
98MP0003279_aneurysm0.57512198
99MP0005083_abnormal_biliary_tract0.57496706
100MP0003656_abnormal_erythrocyte_physiolo0.57065609

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.22652421
2Recurrent abscess formation (HP:0002722)5.16416344
3Recurrent bacterial skin infections (HP:0005406)5.03181440
4Abnormality of macrophages (HP:0004311)4.80590058
5Myositis (HP:0100614)4.57026142
6Orchitis (HP:0100796)4.14274034
7Recurrent gram-negative bacterial infections (HP:0005420)4.00142692
8Retrobulbar optic neuritis (HP:0100654)3.65132014
9Optic neuritis (HP:0100653)3.65132014
10Gastrointestinal infarctions (HP:0005244)3.62496427
11Chronic obstructive pulmonary disease (HP:0006510)3.60790188
12Obstructive lung disease (HP:0006536)3.60790188
13Recurrent fungal infections (HP:0002841)3.60737109
14Spontaneous hematomas (HP:0007420)3.59672272
15Elevated erythrocyte sedimentation rate (HP:0003565)3.54197428
16Mediastinal lymphadenopathy (HP:0100721)3.50492882
17Increased IgE level (HP:0003212)3.46832347
18Stomatitis (HP:0010280)3.44652637
19Meningitis (HP:0001287)3.40229309
20Recurrent skin infections (HP:0001581)3.33087019
21Gingivitis (HP:0000230)3.25810430
22Cellulitis (HP:0100658)3.22516089
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.17602148
24Chronic mucocutaneous candidiasis (HP:0002728)2.97091099
25Recurrent cutaneous fungal infections (HP:0011370)2.97091099
26Prolonged bleeding time (HP:0003010)2.93637068
27Vasculitis (HP:0002633)2.90380808
28Pustule (HP:0200039)2.86940279
29Urticaria (HP:0001025)2.85832044
30Gastrointestinal inflammation (HP:0004386)2.80677516
31Encephalitis (HP:0002383)2.74143597
32Hypochromic anemia (HP:0001931)2.72414358
33Inflammation of the large intestine (HP:0002037)2.71588657
34Petechiae (HP:0000967)2.68157004
35Chest pain (HP:0100749)2.66091703
36Recurrent viral infections (HP:0004429)2.58174907
37Keratoconjunctivitis sicca (HP:0001097)2.57803274
38Epistaxis (HP:0000421)2.54555545
39Colitis (HP:0002583)2.53847036
40Hemoptysis (HP:0002105)2.47073558
41Hypochromic microcytic anemia (HP:0004840)2.44854062
42Increased cerebral lipofuscin (HP:0011813)2.44174407
43Gingival bleeding (HP:0000225)2.41566305
44Dysostosis multiplex (HP:0000943)2.38015685
45Peritonitis (HP:0002586)2.37702525
46Pulmonary infiltrates (HP:0002113)2.37343152
47Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.34858464
48Keratoconjunctivitis (HP:0001096)2.32490821
49Loss of speech (HP:0002371)2.31588356
50Osteomyelitis (HP:0002754)2.31442728
51Episodic fever (HP:0001954)2.28491721
52Anorexia (HP:0002039)2.27857464
53Arterial thrombosis (HP:0004420)2.26531428
54Abnormality of glycolipid metabolism (HP:0010969)2.25979101
55Abnormality of liposaccharide metabolism (HP:0010968)2.25979101
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.25979101
57Panhypogammaglobulinemia (HP:0003139)2.25788989
58T lymphocytopenia (HP:0005403)2.25638999
59Pulmonary embolism (HP:0002204)2.25565111
60Slow saccadic eye movements (HP:0000514)2.24750418
61Purpura (HP:0000979)2.18080450
62Amyloidosis (HP:0011034)2.17447871
63Malnutrition (HP:0004395)2.15018844
64Lymphopenia (HP:0001888)2.13706856
65Thin bony cortex (HP:0002753)2.09652509
66Sepsis (HP:0100806)2.07916260
67Obstructive sleep apnea (HP:0002870)2.07398893
68Gastrointestinal stroma tumor (HP:0100723)2.06660010
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.05434927
70Abnormality of polysaccharide metabolism (HP:0011012)2.05044993
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05044993
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05044993
73Abnormality of T cell number (HP:0011839)2.04462900
74Granulocytopenia (HP:0001913)2.01413277
75Hemorrhage of the eye (HP:0011885)2.00364863
76Increased serum ferritin (HP:0003281)1.99481137
77Abnormality of cells of the lymphoid lineage (HP:0012140)1.98561287
78Hypergammaglobulinemia (HP:0010702)1.97368106
79Mucopolysacchariduria (HP:0008155)1.96842040
80Urinary glycosaminoglycan excretion (HP:0003541)1.96842040
81Premature loss of primary teeth (HP:0006323)1.96483101
82Increased IgM level (HP:0003496)1.96323099
83Hepatosplenomegaly (HP:0001433)1.95999588
84Leukocytosis (HP:0001974)1.95950184
85Microcytic anemia (HP:0001935)1.95623976
86Metaphyseal cupping (HP:0003021)1.94092061
87Abnormality of T cells (HP:0002843)1.91712216
88Segmental peripheral demyelination/remyelination (HP:0003481)1.91707639
89Abnormality of the peritoneum (HP:0002585)1.91436763
90Polygenic inheritance (HP:0010982)1.89388357
91Systemic lupus erythematosus (HP:0002725)1.88368450
92Emphysema (HP:0002097)1.88098604
93Skin ulcer (HP:0200042)1.87410316
94Polycythemia (HP:0001901)1.87397979
95Abnormality of the fingertips (HP:0001211)1.87198040
96Neuronal loss in central nervous system (HP:0002529)1.85771694
97Restrictive lung disease (HP:0002091)1.85656951
98Acne (HP:0001061)1.83458760
99Papilloma (HP:0012740)1.82114936
100Verrucae (HP:0200043)1.82114936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.97046207
2ERN13.65814356
3MAP4K13.44882715
4TRIB33.17729882
5PRPF4B3.06000616
6MAP2K32.88747139
7IRAK42.54601678
8BLK2.50870319
9TYK22.40301144
10TNK22.05443391
11CSK2.04206252
12SIK11.98583157
13SMG11.98026488
14MAP3K31.96217256
15GRK61.95856909
16EPHB11.90243494
17ZAP701.86590678
18TAOK11.80216766
19FES1.75273165
20MAP3K111.74413171
21JAK31.59596193
22SIK31.58032430
23MAP3K131.57190211
24BTK1.44775105
25MAP3K141.44365283
26FGFR41.36855059
27FGR1.35148899
28HCK1.35118653
29KSR21.34060799
30MAP3K11.33419857
31TBK11.32299402
32MARK21.30974506
33SIK21.30379660
34PTK61.24126707
35PRKD21.20188564
36CDK121.16967570
37SYK1.16352481
38TAOK21.12348776
39IKBKE1.10411134
40MAP3K101.10391947
41IRAK31.08062887
42JAK11.07351312
43PKN21.05694743
44JAK21.02321563
45RIPK10.98861240
46ICK0.97997160
47CDC42BPA0.97514488
48PDPK10.97033026
49IRAK20.95381186
50LYN0.93038763
51TXK0.90341301
52CSF1R0.90324933
53PDK10.88668240
54TESK20.88105488
55LCK0.86844882
56MAP3K60.83913440
57ITK0.82361685
58YES10.75682353
59MAPK120.75066455
60CAMKK10.74696032
61HIPK20.74220666
62FGFR30.73802857
63MAP3K70.71653146
64MARK30.66483179
65MAP3K20.65758418
66LRRK20.65723633
67IKBKB0.63208474
68RET0.62642188
69STK380.59315309
70RPS6KC10.58338650
71RPS6KL10.58338650
72MATK0.57304449
73STK100.57252711
74DYRK1B0.56896474
75IRAK10.56215210
76PAK40.54564022
77SGK30.53043054
78FYN0.51847285
79RPS6KA20.50229528
80MAP2K60.49238945
81BMX0.48747470
82MAPK70.48532394
83PRKG20.48513721
84TGFBR20.47301762
85KIT0.43860878
86RPS6KA60.42695072
87TTN0.42120577
88MAPK110.41544298
89STK110.39609846
90MAPKAPK20.39373239
91MAP2K20.38857779
92CDK40.37775960
93EEF2K0.37108586
94MAP3K80.36236051
95MAP2K40.32374023
96PRKCH0.31856693
97BMPR20.31307328
98PRKD10.30694731
99PTK2B0.28923984
100RAF10.28835264

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.71579964
2Leishmaniasis_Homo sapiens_hsa051402.45724465
3B cell receptor signaling pathway_Homo sapiens_hsa046622.30608789
4Other glycan degradation_Homo sapiens_hsa005112.28992852
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.13146410
6Staphylococcus aureus infection_Homo sapiens_hsa051502.09025229
7Acute myeloid leukemia_Homo sapiens_hsa052212.05220856
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89929536
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89573220
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.87801234
11Tuberculosis_Homo sapiens_hsa051521.84254561
12Graft-versus-host disease_Homo sapiens_hsa053321.71171689
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.70591288
14Allograft rejection_Homo sapiens_hsa053301.69106770
15Primary immunodeficiency_Homo sapiens_hsa053401.67298357
16T cell receptor signaling pathway_Homo sapiens_hsa046601.62397272
17Autoimmune thyroid disease_Homo sapiens_hsa053201.57960919
18Non-small cell lung cancer_Homo sapiens_hsa052231.53931229
19Chemokine signaling pathway_Homo sapiens_hsa040621.52202877
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.49751966
21Measles_Homo sapiens_hsa051621.48167684
22Toxoplasmosis_Homo sapiens_hsa051451.45585106
23Influenza A_Homo sapiens_hsa051641.39975304
24VEGF signaling pathway_Homo sapiens_hsa043701.39609427
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39540877
26Chronic myeloid leukemia_Homo sapiens_hsa052201.38471389
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37357489
28Malaria_Homo sapiens_hsa051441.36201765
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33770444
30TNF signaling pathway_Homo sapiens_hsa046681.28399812
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26806713
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25719179
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.22537740
34Pancreatic cancer_Homo sapiens_hsa052121.22189603
35Viral myocarditis_Homo sapiens_hsa054161.21261864
36Hepatitis C_Homo sapiens_hsa051601.20713181
37Type I diabetes mellitus_Homo sapiens_hsa049401.19302328
38Hematopoietic cell lineage_Homo sapiens_hsa046401.19186429
39Hepatitis B_Homo sapiens_hsa051611.18843462
40Antigen processing and presentation_Homo sapiens_hsa046121.18321187
41Herpes simplex infection_Homo sapiens_hsa051681.17313457
42Phagosome_Homo sapiens_hsa041451.13040833
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.10387327
44Notch signaling pathway_Homo sapiens_hsa043301.08393802
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.07221827
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.04654228
47Legionellosis_Homo sapiens_hsa051341.04445061
48Renal cell carcinoma_Homo sapiens_hsa052111.03852911
49Lysosome_Homo sapiens_hsa041421.03697307
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01333208
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00010543
52Endometrial cancer_Homo sapiens_hsa052130.99815995
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97616425
54Platelet activation_Homo sapiens_hsa046110.97285028
55Shigellosis_Homo sapiens_hsa051310.97036530
56Apoptosis_Homo sapiens_hsa042100.96884326
57Prolactin signaling pathway_Homo sapiens_hsa049170.95755137
58Salmonella infection_Homo sapiens_hsa051320.95449616
59African trypanosomiasis_Homo sapiens_hsa051430.94576085
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.93661389
61Endocytosis_Homo sapiens_hsa041440.93610652
62Pertussis_Homo sapiens_hsa051330.92592059
63mTOR signaling pathway_Homo sapiens_hsa041500.91753239
64GnRH signaling pathway_Homo sapiens_hsa049120.90211151
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.90058130
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.85608025
67Choline metabolism in cancer_Homo sapiens_hsa052310.85025920
68Inositol phosphate metabolism_Homo sapiens_hsa005620.82096999
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79198506
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.75519628
71ErbB signaling pathway_Homo sapiens_hsa040120.72155299
72Viral carcinogenesis_Homo sapiens_hsa052030.71273810
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70157509
74Rheumatoid arthritis_Homo sapiens_hsa053230.69429356
75Colorectal cancer_Homo sapiens_hsa052100.69008381
76Amoebiasis_Homo sapiens_hsa051460.68836495
77Insulin resistance_Homo sapiens_hsa049310.68154935
78Glioma_Homo sapiens_hsa052140.68134812
79FoxO signaling pathway_Homo sapiens_hsa040680.67910182
80Epstein-Barr virus infection_Homo sapiens_hsa051690.65980408
81Bladder cancer_Homo sapiens_hsa052190.64523685
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64310032
83Insulin signaling pathway_Homo sapiens_hsa049100.63542694
84HTLV-I infection_Homo sapiens_hsa051660.63154613
85Estrogen signaling pathway_Homo sapiens_hsa049150.63045819
86Thyroid cancer_Homo sapiens_hsa052160.61494104
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61173108
88Asthma_Homo sapiens_hsa053100.58741440
89HIF-1 signaling pathway_Homo sapiens_hsa040660.57350898
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56207756
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56114228
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56056355
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.55515659
94MAPK signaling pathway_Homo sapiens_hsa040100.54660231
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.54440859
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53935375
97Prostate cancer_Homo sapiens_hsa052150.53405209
98Prion diseases_Homo sapiens_hsa050200.52828571
99Long-term potentiation_Homo sapiens_hsa047200.51689209
100Type II diabetes mellitus_Homo sapiens_hsa049300.51602819

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