C7ORF49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)4.25042522
2positive regulation by symbiont of host defense response (GO:0052509)4.00968657
3modulation by symbiont of host defense response (GO:0052031)4.00968657
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.00968657
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.00968657
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.00968657
7modulation by symbiont of host immune response (GO:0052553)4.00968657
8response to peptidoglycan (GO:0032494)3.88142665
9positive regulation of gamma-delta T cell activation (GO:0046645)3.77949457
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.57290041
11immunoglobulin mediated immune response (GO:0016064)3.48298283
12detection of other organism (GO:0098543)3.20281321
13negative regulation of interleukin-12 production (GO:0032695)3.19980816
14antigen processing and presentation of endogenous antigen (GO:0019883)3.18271791
15B cell mediated immunity (GO:0019724)3.18200309
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.15282485
17positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.14385273
18response to host immune response (GO:0052572)3.14295410
19response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.14295410
20detection of bacterium (GO:0016045)3.06684033
21pinocytosis (GO:0006907)2.96894705
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96642288
23negative regulation of cell killing (GO:0031342)2.96642288
24regulation of B cell receptor signaling pathway (GO:0050855)2.96010713
25positive regulation of B cell differentiation (GO:0045579)2.94847813
26regulation of interferon-beta biosynthetic process (GO:0045357)2.91817744
27response to host (GO:0075136)2.88484523
28response to host defenses (GO:0052200)2.88484523
29response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.88484523
30macrophage activation involved in immune response (GO:0002281)2.83944765
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80055059
32detection of molecule of bacterial origin (GO:0032490)2.77719189
33detection of external biotic stimulus (GO:0098581)2.77709191
34neutrophil activation (GO:0042119)2.76564749
35regulation of mast cell degranulation (GO:0043304)2.73945578
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71549095
37cellular response to type I interferon (GO:0071357)2.71472364
38type I interferon signaling pathway (GO:0060337)2.71472364
39myeloid cell activation involved in immune response (GO:0002275)2.69232503
40pentose-phosphate shunt (GO:0006098)2.67839270
41regulation of gamma-delta T cell activation (GO:0046643)2.67144435
42response to type I interferon (GO:0034340)2.66934270
43granulocyte activation (GO:0036230)2.65796872
44regulation of superoxide anion generation (GO:0032928)2.59562483
45negative regulation of myeloid cell apoptotic process (GO:0033033)2.59198775
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.59037314
47cellular extravasation (GO:0045123)2.57294725
48NADPH regeneration (GO:0006740)2.55427370
49positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.54332576
50NIK/NF-kappaB signaling (GO:0038061)2.54021913
51lipopolysaccharide-mediated signaling pathway (GO:0031663)2.50205487
52positive regulation of interferon-alpha production (GO:0032727)2.48938917
53response to interferon-beta (GO:0035456)2.47349145
54negative regulation of erythrocyte differentiation (GO:0045647)2.44505725
55antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.42987158
56regulation of mast cell activation involved in immune response (GO:0033006)2.42333234
57regulation of myeloid leukocyte mediated immunity (GO:0002886)2.39467613
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.39431011
59regulation of interferon-alpha production (GO:0032647)2.38556265
60B cell receptor signaling pathway (GO:0050853)2.36123618
61respiratory burst (GO:0045730)2.34574353
62positive regulation of macrophage differentiation (GO:0045651)2.34284370
63detection of biotic stimulus (GO:0009595)2.34171804
64leukocyte degranulation (GO:0043299)2.33903003
65N-acetylneuraminate metabolic process (GO:0006054)2.33685568
66regulation of gamma-delta T cell differentiation (GO:0045586)2.31623349
67protoporphyrinogen IX metabolic process (GO:0046501)2.31392966
68regulation of B cell apoptotic process (GO:0002902)2.31279622
69pentose metabolic process (GO:0019321)2.30683638
70regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.30458000
71negative regulation of innate immune response (GO:0045824)2.30187873
72amino sugar catabolic process (GO:0046348)2.29580375
73regulation of leukocyte degranulation (GO:0043300)2.29542240
74defense response to protozoan (GO:0042832)2.29409607
75regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.28793478
76pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.28547372
77negative regulation of B cell apoptotic process (GO:0002903)2.27978598
78mitochondrial calcium ion transport (GO:0006851)2.27972971
79response to muramyl dipeptide (GO:0032495)2.26837693
80leukocyte migration involved in inflammatory response (GO:0002523)2.26235889
81positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.25823431
82positive regulation of Cdc42 GTPase activity (GO:0043089)2.24705110
83G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.23910809
84regulation of B cell differentiation (GO:0045577)2.23590610
853-UTR-mediated mRNA stabilization (GO:0070935)2.22571124
86interferon-gamma-mediated signaling pathway (GO:0060333)2.21838677
87negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.21394806
88positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.21224415
89positive regulation of mast cell activation (GO:0033005)2.20803450
90antigen processing and presentation via MHC class Ib (GO:0002475)2.20459273
91cellular response to interferon-beta (GO:0035458)2.20321892
92protein maturation by protein folding (GO:0022417)2.17964445
93response to protozoan (GO:0001562)2.17784303
94positive regulation of interferon-beta production (GO:0032728)2.17291913
95Arp2/3 complex-mediated actin nucleation (GO:0034314)2.16987458
96positive regulation of interleukin-10 production (GO:0032733)2.16427139
97positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.15953731
98purine nucleotide salvage (GO:0032261)2.15398968
99cell wall macromolecule catabolic process (GO:0016998)2.15025456
100cellular response to arsenic-containing substance (GO:0071243)2.14886505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.74841486
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.00204090
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.60846885
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41892993
5VDR_21846776_ChIP-Seq_THP-1_Human2.27207537
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21880225
7* MYC_22102868_ChIP-Seq_BL_Human2.20185966
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15141625
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14513566
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14346536
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.08865946
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.06562804
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02775061
14SPI1_23547873_ChIP-Seq_NB4_Human1.99610793
15IRF8_21731497_ChIP-ChIP_J774_Mouse1.97310075
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.92377573
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92362555
18SCL_19346495_ChIP-Seq_HPC-7_Human1.89175583
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88057966
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87755628
21MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87214635
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85356411
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.80837189
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78360966
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78019910
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.76716572
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76003326
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69768011
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68876716
30SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.67797449
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67758445
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64920345
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63403090
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61641503
35MAF_26560356_Chip-Seq_TH1_Human1.60225540
36VDR_24763502_ChIP-Seq_THP-1_Human1.58823226
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58273115
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56162604
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.54283270
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53664459
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50326268
42CIITA_25753668_ChIP-Seq_RAJI_Human1.47413049
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.45592059
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44745291
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43786253
46UTX_26944678_Chip-Seq_JUKART_Human1.43628079
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43514692
48TFEB_21752829_ChIP-Seq_HELA_Human1.43257809
49GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43089187
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43051899
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41753769
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41022406
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40506192
54MYB_26560356_Chip-Seq_TH2_Human1.40064658
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.39075785
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38275896
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37843672
58DCP1A_22483619_ChIP-Seq_HELA_Human1.37190685
59SPI1_23127762_ChIP-Seq_K562_Human1.34826571
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34675824
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33798024
62FOXP3_21729870_ChIP-Seq_TREG_Human1.33692061
63MYB_26560356_Chip-Seq_TH1_Human1.33349590
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.32531382
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32405435
66* GABP_19822575_ChIP-Seq_HepG2_Human1.31080808
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29658718
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.28953361
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.28840054
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27747401
71MAF_26560356_Chip-Seq_TH2_Human1.27627060
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27256103
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26000987
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25883513
75XRN2_22483619_ChIP-Seq_HELA_Human1.24495503
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23043016
77NCOR1_26117541_ChIP-Seq_K562_Human1.22265438
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19462335
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18491453
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17801935
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17656704
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.17266129
83EST1_17652178_ChIP-ChIP_JURKAT_Human1.17085526
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16782588
85VDR_23849224_ChIP-Seq_CD4+_Human1.16398407
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14809772
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12654666
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12236063
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11087034
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10392176
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10049765
92TCF7_22412390_ChIP-Seq_EML_Mouse1.09376747
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09227482
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09020587
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08812841
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08764568
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08573709
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08000043
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06634037
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06616472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology3.29413166
2MP0003724_increased_susceptibility_to2.99184622
3MP0003303_peritoneal_inflammation2.98225655
4MP0001835_abnormal_antigen_presentation2.95733552
5MP0008260_abnormal_autophagy2.75041190
6MP0003436_decreased_susceptibility_to2.74707589
7MP0005451_abnormal_body_composition2.65765078
8MP0003191_abnormal_cellular_cholesterol2.63498455
9MP0003806_abnormal_nucleotide_metabolis2.28353761
10MP0002419_abnormal_innate_immunity2.23032811
11MP0002132_abnormal_respiratory_system2.18702843
12MP0005058_abnormal_lysosome_morphology2.17506816
13MP0005000_abnormal_immune_tolerance2.11023431
14MP0009333_abnormal_splenocyte_physiolog2.06312526
15MP0005671_abnormal_response_to2.05986321
16MP0005025_abnormal_response_to2.05592281
17MP0000685_abnormal_immune_system2.05447191
18MP0002148_abnormal_hypersensitivity_rea2.03902560
19MP0001800_abnormal_humoral_immune2.01078707
20MP0009785_altered_susceptibility_to2.00410447
21MP0003300_gastrointestinal_ulcer2.00047496
22MP0002452_abnormal_antigen_presenting1.95643708
23MP0002723_abnormal_immune_serum1.93895145
24MP0003763_abnormal_thymus_physiology1.90898930
25MP0009278_abnormal_bone_marrow1.88645946
26MP0002420_abnormal_adaptive_immunity1.84738212
27MP0002398_abnormal_bone_marrow1.83622805
28MP0001819_abnormal_immune_cell1.83551515
29MP0005397_hematopoietic_system_phenotyp1.77416509
30MP0001545_abnormal_hematopoietic_system1.77416509
31MP0003172_abnormal_lysosome_physiology1.77131119
32MP0005387_immune_system_phenotype1.74400375
33MP0001790_abnormal_immune_system1.74400375
34MP0002396_abnormal_hematopoietic_system1.73656999
35MP0009840_abnormal_foam_cell1.66843383
36MP0003656_abnormal_erythrocyte_physiolo1.63661047
37MP0000716_abnormal_immune_system1.59845266
38MP0000689_abnormal_spleen_morphology1.56128368
39MP0002722_abnormal_immune_system1.55323930
40MP0002429_abnormal_blood_cell1.54866344
41MP0000858_altered_metastatic_potential1.52083106
42MP0003111_abnormal_nucleus_morphology1.47853032
43MP0004947_skin_inflammation1.46757548
44MP0001853_heart_inflammation1.43487861
45MP0001845_abnormal_inflammatory_respons1.40903269
46MP0002405_respiratory_system_inflammati1.40761738
47MP0000465_gastrointestinal_hemorrhage1.39500126
48MP0008004_abnormal_stomach_pH1.39079291
49MP0010094_abnormal_chromosome_stability1.37808019
50MP0000703_abnormal_thymus_morphology1.34621429
51MP0001533_abnormal_skeleton_physiology1.34036060
52MP0009764_decreased_sensitivity_to1.32378081
53MP0008469_abnormal_protein_level1.31830143
54MP0010155_abnormal_intestine_physiology1.31391446
55MP0006082_CNS_inflammation1.30890814
56MP0004381_abnormal_hair_follicle1.27995238
57MP0003183_abnormal_peptide_metabolism1.26854398
58MP0008057_abnormal_DNA_replication1.25525167
59MP0006035_abnormal_mitochondrial_morpho1.22041235
60MP0003693_abnormal_embryo_hatching1.21505896
61MP0003186_abnormal_redox_activity1.20777482
62MP0004808_abnormal_hematopoietic_stem1.19182775
63MP0003077_abnormal_cell_cycle1.17227718
64MP0000343_altered_response_to1.14930658
65MP0004510_myositis1.13773130
66MP0004957_abnormal_blastocyst_morpholog1.12742133
67MP0006036_abnormal_mitochondrial_physio1.09654276
68MP0002019_abnormal_tumor_incidence1.08218113
69MP0000490_abnormal_crypts_of1.06742975
70MP0009763_increased_sensitivity_to1.03297507
71MP0005075_abnormal_melanosome_morpholog1.02324402
72MP0003075_altered_response_to0.99624988
73MP0000313_abnormal_cell_death0.97126695
74MP0002877_abnormal_melanocyte_morpholog0.96973321
75MP0003866_abnormal_defecation0.96325500
76MP0001851_eye_inflammation0.95131928
77MP0003566_abnormal_cell_adhesion0.91454627
78MP0003828_pulmonary_edema0.91288832
79MP0008058_abnormal_DNA_repair0.90730368
80MP0000015_abnormal_ear_pigmentation0.90562755
81MP0003786_premature_aging0.90239803
82MP0008007_abnormal_cellular_replicative0.85861685
83MP0004185_abnormal_adipocyte_glucose0.84588986
84MP0000372_irregular_coat_pigmentation0.82398158
85MP0000609_abnormal_liver_physiology0.81063764
86MP0003221_abnormal_cardiomyocyte_apopto0.79879846
87MP0005319_abnormal_enzyme/_coenzyme0.79788343
88MP0002139_abnormal_hepatobiliary_system0.79408488
89MP0005310_abnormal_salivary_gland0.79370604
90MP0009765_abnormal_xenobiotic_induced0.78981837
91MP0001661_extended_life_span0.78169349
92MP0002166_altered_tumor_susceptibility0.77599136
93MP0000350_abnormal_cell_proliferation0.77176380
94MP0001730_embryonic_growth_arrest0.76912190
95MP0002998_abnormal_bone_remodeling0.76445514
96MP0005666_abnormal_adipose_tissue0.76102845
97MP0000358_abnormal_cell_content/0.75966720
98MP0000598_abnormal_liver_morphology0.73763968
99MP0001764_abnormal_homeostasis0.73324731
100MP0005621_abnormal_cell_physiology0.73157733

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)4.82450134
2Recurrent abscess formation (HP:0002722)4.31383177
3Eczematoid dermatitis (HP:0000976)4.18859617
4Prolonged bleeding time (HP:0003010)4.12884599
5Recurrent bacterial skin infections (HP:0005406)4.06938258
6Abnormality of macrophages (HP:0004311)3.91007132
7Purpura (HP:0000979)3.78548613
8Gingival bleeding (HP:0000225)3.63529106
9Epistaxis (HP:0000421)3.61736926
10Obstructive lung disease (HP:0006536)3.46231149
11Chronic obstructive pulmonary disease (HP:0006510)3.46231149
12Abnormal platelet volume (HP:0011876)3.27248887
13Mediastinal lymphadenopathy (HP:0100721)3.22974420
14Recurrent fungal infections (HP:0002841)3.06353227
15Hepatosplenomegaly (HP:0001433)3.00964195
16Myositis (HP:0100614)2.98059262
17Increased mean platelet volume (HP:0011877)2.97125617
18Menorrhagia (HP:0000132)2.90479457
19Elevated erythrocyte sedimentation rate (HP:0003565)2.90110338
20Abnormality of glycolipid metabolism (HP:0010969)2.85944733
21Abnormality of liposaccharide metabolism (HP:0010968)2.85944733
22Abnormality of glycosphingolipid metabolism (HP:0004343)2.85944733
23Orchitis (HP:0100796)2.84306351
24Recurrent viral infections (HP:0004429)2.82622802
25Stomatitis (HP:0010280)2.77840869
26Impaired platelet aggregation (HP:0003540)2.75732529
27Abnormal platelet function (HP:0011869)2.75732529
28Meningitis (HP:0001287)2.74689809
29Abnormality of the heme biosynthetic pathway (HP:0010472)2.73546634
30Recurrent skin infections (HP:0001581)2.71093806
31Colitis (HP:0002583)2.70337312
32Acute hepatic failure (HP:0006554)2.67716059
33Urticaria (HP:0001025)2.63630795
34Gastrointestinal infarctions (HP:0005244)2.61260873
35Recurrent gram-negative bacterial infections (HP:0005420)2.60204925
36Increased IgM level (HP:0003496)2.60140818
37Increased serum ferritin (HP:0003281)2.57464528
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.54099713
39Gastrointestinal inflammation (HP:0004386)2.52698645
40Cellulitis (HP:0100658)2.49771232
41Inflammation of the large intestine (HP:0002037)2.48215948
42Recurrent cutaneous fungal infections (HP:0011370)2.46323730
43Chronic mucocutaneous candidiasis (HP:0002728)2.46323730
44Retrobulbar optic neuritis (HP:0100654)2.44739652
45Optic neuritis (HP:0100653)2.44739652
46Spontaneous hematomas (HP:0007420)2.44156966
47Encephalitis (HP:0002383)2.42401754
48Autoimmune hemolytic anemia (HP:0001890)2.39238841
49Vasculitis (HP:0002633)2.38641180
50Anorexia (HP:0002039)2.37463736
51Hypertensive crisis (HP:0100735)2.36404296
52Fatigue (HP:0012378)2.34615962
53Increased cerebral lipofuscin (HP:0011813)2.34455335
54Arterial thrombosis (HP:0004420)2.32243188
55Loss of speech (HP:0002371)2.31982786
56Abnormality of iron homeostasis (HP:0011031)2.31060707
57Ragged-red muscle fibers (HP:0003200)2.26783417
58Panhypogammaglobulinemia (HP:0003139)2.24217590
59Abnormality of T cell physiology (HP:0011840)2.21619797
60Chest pain (HP:0100749)2.17627419
61IgM deficiency (HP:0002850)2.11877460
62Abnormality of T cells (HP:0002843)2.10953772
63Granulocytopenia (HP:0001913)2.10404546
64Progressive muscle weakness (HP:0003323)2.09994293
65Agammaglobulinemia (HP:0004432)2.07487135
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.07483398
67Increased IgE level (HP:0003212)2.04789980
68Osteomyelitis (HP:0002754)2.04071440
69Cholecystitis (HP:0001082)2.03665863
70Abnormal gallbladder physiology (HP:0012438)2.03665863
71Myocardial infarction (HP:0001658)2.01033478
72Pustule (HP:0200039)2.00907884
73Joint swelling (HP:0001386)2.00386724
74Vacuolated lymphocytes (HP:0001922)1.99951449
75Aplasia/Hypoplasia of the thymus (HP:0010515)1.98418646
76Viral hepatitis (HP:0006562)1.93849075
77Abnormality of transition element cation homeostasis (HP:0011030)1.93826380
78Gingivitis (HP:0000230)1.91919892
79Aplastic anemia (HP:0001915)1.90585620
80Prolonged neonatal jaundice (HP:0006579)1.88358259
81T lymphocytopenia (HP:0005403)1.87630113
82Progressive neurologic deterioration (HP:0002344)1.85438944
83Rough bone trabeculation (HP:0100670)1.84894675
84Amyloidosis (HP:0011034)1.83942651
85Nausea (HP:0002018)1.82158345
86Keratoconjunctivitis sicca (HP:0001097)1.81921997
87Polycythemia (HP:0001901)1.81377162
88Abnormality of the vasculature of the conjunctiva (HP:0008054)1.80948498
89Thrombophlebitis (HP:0004418)1.80858864
90Paralysis (HP:0003470)1.78764093
91Skin rash (HP:0000988)1.78435340
92Splenomegaly (HP:0001744)1.77343472
93Leukocytosis (HP:0001974)1.77130978
94Systemic lupus erythematosus (HP:0002725)1.76577361
95Seborrheic dermatitis (HP:0001051)1.76062173
96Abnormality of T cell number (HP:0011839)1.75944551
97Microvesicular hepatic steatosis (HP:0001414)1.75142143
98Skin ulcer (HP:0200042)1.74521178
99Amaurosis fugax (HP:0100576)1.74112533
100Dysostosis multiplex (HP:0000943)1.73391318

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K33.19132187
2RIPK43.00215266
3NME22.84667844
4ERN12.68186277
5IRAK42.64386840
6MAP4K12.60334480
7BLK2.34422996
8IRAK32.30109728
9TESK22.26037224
10EIF2AK12.11723799
11TYK21.98798135
12BUB11.97273508
13MAP3K31.94636377
14MAP3K111.94578293
15SMG11.94144161
16TAOK21.66741136
17PRPF4B1.66350988
18JAK31.64485403
19TXK1.63737603
20TBK11.59309892
21STK101.58772752
22BTK1.52509521
23ZAP701.50993756
24MAP3K141.42841773
25GRK61.37838999
26FGR1.32275315
27TRIB31.29212181
28PIM21.27640479
29KDR1.27570157
30CSF1R1.23304468
31IKBKE1.21284246
32CSK1.20227228
33SYK1.17753467
34IKBKB1.15494737
35VRK21.14428938
36SCYL21.13649920
37BCKDK1.11462463
38EPHB11.09145935
39HCK1.08602222
40MAP3K11.08397815
41TAOK31.06778417
42FES1.06217303
43MAP3K81.05686563
44STK41.02978572
45TNK21.01353109
46MARK30.99008005
47LYN0.98543742
48PAK40.98458393
49SIK30.95761138
50CDK120.95541784
51IRAK10.94610330
52PBK0.94419481
53BMX0.93440228
54IRAK20.93397201
55JAK20.92676283
56MATK0.92333140
57TAOK10.85480270
58LRRK20.80774581
59SRPK10.79361226
60MAPK110.77866841
61MAP3K50.77275734
62CDK40.76608410
63MAP3K130.75133457
64MST40.73689960
65FGFR40.72813455
66RAF10.67415143
67PAK10.62599523
68PIM10.62129100
69STK160.61811534
70EIF2AK30.61723888
71CDK70.60310399
72SIK10.59833982
73CCNB10.56217863
74TGFBR20.55962315
75LCK0.54149531
76JAK10.53352975
77KSR20.52826423
78TEC0.52125356
79CDC70.51168636
80PRKD20.50691447
81AURKA0.49401790
82CLK10.49306347
83DAPK10.49007070
84RPS6KA40.48977171
85MAPKAPK20.46783792
86PIK3CG0.45768460
87KIT0.44841400
88ABL20.44658065
89HIPK20.44393049
90GRK70.44129173
91PDPK10.40554056
92PTK60.39579625
93ITK0.39540212
94ILK0.38546479
95RPS6KA50.38439670
96NME10.37478273
97CDK60.36875923
98ATR0.35950811
99BRSK20.34808722
100MOS0.34581226

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.54285513
2Other glycan degradation_Homo sapiens_hsa005112.33030872
3Proteasome_Homo sapiens_hsa030502.22594872
4Leishmaniasis_Homo sapiens_hsa051402.05082409
5Staphylococcus aureus infection_Homo sapiens_hsa051501.90596142
6Base excision repair_Homo sapiens_hsa034101.87423646
7Allograft rejection_Homo sapiens_hsa053301.81727441
8Osteoclast differentiation_Homo sapiens_hsa043801.79349000
9Primary immunodeficiency_Homo sapiens_hsa053401.76849106
10Mismatch repair_Homo sapiens_hsa034301.76728042
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70126507
12Graft-versus-host disease_Homo sapiens_hsa053321.67851591
13Antigen processing and presentation_Homo sapiens_hsa046121.63765179
14Autoimmune thyroid disease_Homo sapiens_hsa053201.61113087
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59071435
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.57097178
17Pentose phosphate pathway_Homo sapiens_hsa000301.56313563
18Herpes simplex infection_Homo sapiens_hsa051681.54631473
19Galactose metabolism_Homo sapiens_hsa000521.50753594
20B cell receptor signaling pathway_Homo sapiens_hsa046621.48378368
21Legionellosis_Homo sapiens_hsa051341.45951082
22Measles_Homo sapiens_hsa051621.43386416
23Acute myeloid leukemia_Homo sapiens_hsa052211.39288577
24Tuberculosis_Homo sapiens_hsa051521.38384913
25Influenza A_Homo sapiens_hsa051641.34664583
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.34048920
27Pyrimidine metabolism_Homo sapiens_hsa002401.33305140
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32632242
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31275814
30Epstein-Barr virus infection_Homo sapiens_hsa051691.27637657
31Hematopoietic cell lineage_Homo sapiens_hsa046401.26996152
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.21427587
33Malaria_Homo sapiens_hsa051441.21361466
34Viral myocarditis_Homo sapiens_hsa054161.20573357
35Systemic lupus erythematosus_Homo sapiens_hsa053221.18104740
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17739042
37Shigellosis_Homo sapiens_hsa051311.17252307
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16984707
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16573673
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16205029
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12162440
42Toxoplasmosis_Homo sapiens_hsa051451.11510725
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10397120
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10232331
45Asthma_Homo sapiens_hsa053101.08328041
46Apoptosis_Homo sapiens_hsa042101.07822860
47Viral carcinogenesis_Homo sapiens_hsa052031.06942603
48Non-small cell lung cancer_Homo sapiens_hsa052231.06345837
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05741369
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04468416
51Type I diabetes mellitus_Homo sapiens_hsa049401.04219713
52Hepatitis B_Homo sapiens_hsa051611.03673669
53Pancreatic cancer_Homo sapiens_hsa052121.02138181
54Fatty acid elongation_Homo sapiens_hsa000621.01973090
55NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01498028
56Biosynthesis of amino acids_Homo sapiens_hsa012300.99367831
57Lysosome_Homo sapiens_hsa041420.98095437
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97882128
59Hepatitis C_Homo sapiens_hsa051600.97066303
60One carbon pool by folate_Homo sapiens_hsa006700.95686554
61Platelet activation_Homo sapiens_hsa046110.93700599
62Spliceosome_Homo sapiens_hsa030400.93292868
63Homologous recombination_Homo sapiens_hsa034400.91142733
64Phagosome_Homo sapiens_hsa041450.90598628
65TNF signaling pathway_Homo sapiens_hsa046680.88041920
66Rheumatoid arthritis_Homo sapiens_hsa053230.86678412
67Chronic myeloid leukemia_Homo sapiens_hsa052200.85944067
68Carbon metabolism_Homo sapiens_hsa012000.84645315
69Nucleotide excision repair_Homo sapiens_hsa034200.77977084
70RNA polymerase_Homo sapiens_hsa030200.77185911
71Fructose and mannose metabolism_Homo sapiens_hsa000510.76284029
72Sulfur relay system_Homo sapiens_hsa041220.75198634
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.73735466
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73655806
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.72030545
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71777344
77Glutathione metabolism_Homo sapiens_hsa004800.71664635
78Chemokine signaling pathway_Homo sapiens_hsa040620.71458466
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69953093
80Non-homologous end-joining_Homo sapiens_hsa034500.67401730
81Bladder cancer_Homo sapiens_hsa052190.65976543
82African trypanosomiasis_Homo sapiens_hsa051430.64393464
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62577863
84Cell cycle_Homo sapiens_hsa041100.62162089
85Salmonella infection_Homo sapiens_hsa051320.61943944
86HTLV-I infection_Homo sapiens_hsa051660.61691853
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.60095858
88Pertussis_Homo sapiens_hsa051330.58692254
89Small cell lung cancer_Homo sapiens_hsa052220.55304861
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53888221
91T cell receptor signaling pathway_Homo sapiens_hsa046600.53058296
92p53 signaling pathway_Homo sapiens_hsa041150.51002208
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.50926228
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50164757
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49891020
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49717937
97Thyroid cancer_Homo sapiens_hsa052160.46667689
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43654307
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42286297
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.41958279

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