

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.27842863 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.51968217 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 6.51968217 |
| 4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.86353364 |
| 5 | respiratory electron transport chain (GO:0022904) | 5.43605540 |
| 6 | electron transport chain (GO:0022900) | 5.38609473 |
| 7 | protein complex biogenesis (GO:0070271) | 5.23839065 |
| 8 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.13774085 |
| 9 | chaperone-mediated protein transport (GO:0072321) | 4.98495943 |
| 10 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.88584745 |
| 11 | NADH dehydrogenase complex assembly (GO:0010257) | 4.68047675 |
| 12 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.68047675 |
| 13 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.68047675 |
| 14 | viral transcription (GO:0019083) | 4.45890721 |
| 15 | translational termination (GO:0006415) | 4.35572622 |
| 16 | ribosomal small subunit assembly (GO:0000028) | 4.32766145 |
| 17 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.14614020 |
| 18 | cotranslational protein targeting to membrane (GO:0006613) | 4.13582501 |
| 19 | protein targeting to ER (GO:0045047) | 4.06953119 |
| 20 | respiratory chain complex IV assembly (GO:0008535) | 3.99384640 |
| 21 | cytochrome complex assembly (GO:0017004) | 3.99378438 |
| 22 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.89207542 |
| 23 | protein-cofactor linkage (GO:0018065) | 3.85079205 |
| 24 | protein localization to endoplasmic reticulum (GO:0070972) | 3.84048442 |
| 25 | hydrogen ion transmembrane transport (GO:1902600) | 3.79829257 |
| 26 | ATP biosynthetic process (GO:0006754) | 3.79139194 |
| 27 | translational elongation (GO:0006414) | 3.75804061 |
| 28 | protein neddylation (GO:0045116) | 3.72785517 |
| 29 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.72768082 |
| 30 | proteasome assembly (GO:0043248) | 3.66091600 |
| 31 | behavioral response to nicotine (GO:0035095) | 3.65098123 |
| 32 | termination of RNA polymerase III transcription (GO:0006386) | 3.62960111 |
| 33 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.62960111 |
| 34 | regulation of mitochondrial translation (GO:0070129) | 3.62407588 |
| 35 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.62380861 |
| 36 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.60181356 |
| 37 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.60146723 |
| 38 | proton transport (GO:0015992) | 3.54251310 |
| 39 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.49833288 |
| 40 | hydrogen transport (GO:0006818) | 3.48087506 |
| 41 | inner mitochondrial membrane organization (GO:0007007) | 3.47739330 |
| 42 | platelet dense granule organization (GO:0060155) | 3.44390786 |
| 43 | cullin deneddylation (GO:0010388) | 3.39559271 |
| 44 | maturation of SSU-rRNA (GO:0030490) | 3.37494436 |
| 45 | DNA deamination (GO:0045006) | 3.37167880 |
| 46 | ribosomal small subunit biogenesis (GO:0042274) | 3.34180920 |
| 47 | viral life cycle (GO:0019058) | 3.27404703 |
| 48 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.27344907 |
| 49 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.27344907 |
| 50 | cellular protein complex disassembly (GO:0043624) | 3.26096247 |
| 51 | translation (GO:0006412) | 3.22334563 |
| 52 | sequestering of actin monomers (GO:0042989) | 3.21758278 |
| 53 | protein deneddylation (GO:0000338) | 3.18319659 |
| 54 | intracellular protein transmembrane import (GO:0044743) | 3.15882319 |
| 55 | oxidative phosphorylation (GO:0006119) | 3.14639187 |
| 56 | mannosylation (GO:0097502) | 3.13484786 |
| 57 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.13251278 |
| 58 | translational initiation (GO:0006413) | 3.09065155 |
| 59 | pseudouridine synthesis (GO:0001522) | 3.08914711 |
| 60 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.04278597 |
| 61 | GTP biosynthetic process (GO:0006183) | 3.00003900 |
| 62 | DNA double-strand break processing (GO:0000729) | 2.96861336 |
| 63 | peptidyl-histidine modification (GO:0018202) | 2.93739238 |
| 64 | epithelial cilium movement (GO:0003351) | 2.92593522 |
| 65 | ribosomal large subunit biogenesis (GO:0042273) | 2.90333696 |
| 66 | protein targeting to mitochondrion (GO:0006626) | 2.89112170 |
| 67 | establishment of protein localization to mitochondrion (GO:0072655) | 2.88387283 |
| 68 | rRNA modification (GO:0000154) | 2.87631649 |
| 69 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.85892243 |
| 70 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.83602273 |
| 71 | ubiquinone biosynthetic process (GO:0006744) | 2.80079855 |
| 72 | nonmotile primary cilium assembly (GO:0035058) | 2.79695164 |
| 73 | protein localization to mitochondrion (GO:0070585) | 2.79239102 |
| 74 | cellular component biogenesis (GO:0044085) | 2.76885469 |
| 75 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.75819878 |
| 76 | mitochondrial transport (GO:0006839) | 2.75594645 |
| 77 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.73844617 |
| 78 | cellular ketone body metabolic process (GO:0046950) | 2.71906508 |
| 79 | DNA damage response, detection of DNA damage (GO:0042769) | 2.71390836 |
| 80 | protein complex disassembly (GO:0043241) | 2.67914702 |
| 81 | regulation of cilium movement (GO:0003352) | 2.66249361 |
| 82 | macromolecular complex disassembly (GO:0032984) | 2.62628357 |
| 83 | GPI anchor metabolic process (GO:0006505) | 2.62428071 |
| 84 | base-excision repair, AP site formation (GO:0006285) | 2.61110713 |
| 85 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.60595231 |
| 86 | ubiquinone metabolic process (GO:0006743) | 2.59398150 |
| 87 | protein targeting to membrane (GO:0006612) | 2.58745190 |
| 88 | tRNA processing (GO:0008033) | 2.57012631 |
| 89 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.57003690 |
| 90 | spliceosomal snRNP assembly (GO:0000387) | 2.55423829 |
| 91 | aldehyde catabolic process (GO:0046185) | 2.52485246 |
| 92 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.51363058 |
| 93 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.50833007 |
| 94 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.50833007 |
| 95 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.50740543 |
| 96 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.50740543 |
| 97 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.50283050 |
| 98 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.48801221 |
| 99 | organelle disassembly (GO:1903008) | 2.48415775 |
| 100 | ketone body metabolic process (GO:1902224) | 2.46970972 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.35663781 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.16616204 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.96675489 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.67845814 |
| 5 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.49016026 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.95240549 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.84509930 |
| 8 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.71779230 |
| 9 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.57918272 |
| 10 | VDR_22108803_ChIP-Seq_LS180_Human | 2.49215832 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.42489554 |
| 12 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.41508166 |
| 13 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.39828438 |
| 14 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.35196166 |
| 15 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.34013879 |
| 16 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.31420372 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.29345678 |
| 18 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.22166585 |
| 19 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.17274098 |
| 20 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.14355563 |
| 21 | MYC_18940864_ChIP-ChIP_HL60_Human | 2.08173930 |
| 22 | FUS_26573619_Chip-Seq_HEK293_Human | 2.01213797 |
| 23 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.94347403 |
| 24 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.91051974 |
| 25 | EWS_26573619_Chip-Seq_HEK293_Human | 1.90256027 |
| 26 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.88103883 |
| 27 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.78405026 |
| 28 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.77219593 |
| 29 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.69182346 |
| 30 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.67631001 |
| 31 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.58771196 |
| 32 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.56827329 |
| 33 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.53092094 |
| 34 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.52339441 |
| 35 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.51868317 |
| 36 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.49795568 |
| 37 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.48708194 |
| 38 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.46140705 |
| 39 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.46055418 |
| 40 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.45439226 |
| 41 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.41217708 |
| 42 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.40726291 |
| 43 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.38965222 |
| 44 | P300_19829295_ChIP-Seq_ESCs_Human | 1.38552229 |
| 45 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.38145567 |
| 46 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.38140263 |
| 47 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.37483771 |
| 48 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.36532753 |
| 49 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.36396349 |
| 50 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.34531848 |
| 51 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.33482450 |
| 52 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.31790115 |
| 53 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.28632943 |
| 54 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.27021081 |
| 55 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.26505198 |
| 56 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.24965403 |
| 57 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.24614278 |
| 58 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.23310783 |
| 59 | * XRN2_22483619_ChIP-Seq_HELA_Human | 1.20216783 |
| 60 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.18986447 |
| 61 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.18140864 |
| 62 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.14647170 |
| 63 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.13981739 |
| 64 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.12807704 |
| 65 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.12379191 |
| 66 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.11916410 |
| 67 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.11798448 |
| 68 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.11798448 |
| 69 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.11251779 |
| 70 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.11241151 |
| 71 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.10904813 |
| 72 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.10904813 |
| 73 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.09994007 |
| 74 | AR_20517297_ChIP-Seq_VCAP_Human | 1.06172703 |
| 75 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.05185501 |
| 76 | * ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.02759235 |
| 77 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.02537436 |
| 78 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.01680880 |
| 79 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.01371999 |
| 80 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.00577924 |
| 81 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.97879518 |
| 82 | NCOR_22424771_ChIP-Seq_293T_Human | 0.97687614 |
| 83 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.96558385 |
| 84 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.96558385 |
| 85 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.92779289 |
| 86 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.91358950 |
| 87 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.88630844 |
| 88 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.88030654 |
| 89 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.87883565 |
| 90 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.87580226 |
| 91 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.86649561 |
| 92 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.86465146 |
| 93 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.84608342 |
| 94 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.84275278 |
| 95 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.83788777 |
| 96 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.83456503 |
| 97 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.83100480 |
| 98 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.82787556 |
| 99 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.81072434 |
| 100 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.80898945 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006292_abnormal_olfactory_placode | 3.04457936 |
| 2 | MP0009379_abnormal_foot_pigmentation | 2.82752664 |
| 3 | MP0002102_abnormal_ear_morphology | 2.37852805 |
| 4 | MP0006072_abnormal_retinal_apoptosis | 2.37661683 |
| 5 | MP0003136_yellow_coat_color | 2.34447955 |
| 6 | MP0002638_abnormal_pupillary_reflex | 2.33688615 |
| 7 | MP0003880_abnormal_central_pattern | 2.32111801 |
| 8 | MP0002837_dystrophic_cardiac_calcinosis | 2.29081694 |
| 9 | MP0000372_irregular_coat_pigmentation | 2.25987299 |
| 10 | MP0002938_white_spotting | 2.19072677 |
| 11 | MP0001529_abnormal_vocalization | 2.17604340 |
| 12 | MP0008058_abnormal_DNA_repair | 1.95193275 |
| 13 | MP0003011_delayed_dark_adaptation | 1.93846574 |
| 14 | MP0003806_abnormal_nucleotide_metabolis | 1.91511870 |
| 15 | MP0005551_abnormal_eye_electrophysiolog | 1.90257340 |
| 16 | MP0008877_abnormal_DNA_methylation | 1.89449702 |
| 17 | MP0004142_abnormal_muscle_tone | 1.86770829 |
| 18 | MP0001968_abnormal_touch/_nociception | 1.86606602 |
| 19 | MP0004145_abnormal_muscle_electrophysio | 1.82327741 |
| 20 | MP0005253_abnormal_eye_physiology | 1.80524080 |
| 21 | MP0005645_abnormal_hypothalamus_physiol | 1.77231511 |
| 22 | MP0002736_abnormal_nociception_after | 1.76444966 |
| 23 | MP0005084_abnormal_gallbladder_morpholo | 1.74232469 |
| 24 | MP0005646_abnormal_pituitary_gland | 1.70871370 |
| 25 | MP0006036_abnormal_mitochondrial_physio | 1.67631689 |
| 26 | MP0001905_abnormal_dopamine_level | 1.66503770 |
| 27 | MP0008875_abnormal_xenobiotic_pharmacok | 1.66237237 |
| 28 | MP0003186_abnormal_redox_activity | 1.66023569 |
| 29 | MP0003195_calcinosis | 1.63945500 |
| 30 | MP0009046_muscle_twitch | 1.63201109 |
| 31 | MP0002234_abnormal_pharynx_morphology | 1.60546013 |
| 32 | MP0003718_maternal_effect | 1.59236588 |
| 33 | MP0004133_heterotaxia | 1.57119919 |
| 34 | MP0001984_abnormal_olfaction | 1.55077805 |
| 35 | MP0000631_abnormal_neuroendocrine_gland | 1.53920478 |
| 36 | MP0006276_abnormal_autonomic_nervous | 1.53413783 |
| 37 | MP0002272_abnormal_nervous_system | 1.51339428 |
| 38 | MP0009745_abnormal_behavioral_response | 1.45524469 |
| 39 | MP0008789_abnormal_olfactory_epithelium | 1.42663365 |
| 40 | MP0001485_abnormal_pinna_reflex | 1.41393300 |
| 41 | MP0005174_abnormal_tail_pigmentation | 1.39245923 |
| 42 | MP0002277_abnormal_respiratory_mucosa | 1.38948454 |
| 43 | MP0008995_early_reproductive_senescence | 1.38540219 |
| 44 | MP0008872_abnormal_physiological_respon | 1.37500113 |
| 45 | MP0002653_abnormal_ependyma_morphology | 1.33369000 |
| 46 | MP0002160_abnormal_reproductive_system | 1.31891723 |
| 47 | MP0010386_abnormal_urinary_bladder | 1.30614272 |
| 48 | MP0006035_abnormal_mitochondrial_morpho | 1.27358319 |
| 49 | MP0002095_abnormal_skin_pigmentation | 1.26030209 |
| 50 | MP0002822_catalepsy | 1.23445049 |
| 51 | MP0001764_abnormal_homeostasis | 1.23342899 |
| 52 | MP0004147_increased_porphyrin_level | 1.23032125 |
| 53 | MP0003787_abnormal_imprinting | 1.22045771 |
| 54 | MP0002876_abnormal_thyroid_physiology | 1.18988421 |
| 55 | MP0002163_abnormal_gland_morphology | 1.16434099 |
| 56 | MP0001293_anophthalmia | 1.15746139 |
| 57 | MP0005075_abnormal_melanosome_morpholog | 1.13432543 |
| 58 | MP0001986_abnormal_taste_sensitivity | 1.12736985 |
| 59 | MP0002735_abnormal_chemical_nociception | 1.12629665 |
| 60 | MP0005389_reproductive_system_phenotype | 1.11020698 |
| 61 | MP0002557_abnormal_social/conspecific_i | 1.10584412 |
| 62 | MP0005379_endocrine/exocrine_gland_phen | 1.08247325 |
| 63 | MP0003283_abnormal_digestive_organ | 1.07337811 |
| 64 | MP0003121_genomic_imprinting | 1.05563458 |
| 65 | MP0001486_abnormal_startle_reflex | 1.03235576 |
| 66 | MP0004885_abnormal_endolymph | 1.00437395 |
| 67 | MP0002928_abnormal_bile_duct | 0.99739905 |
| 68 | MP0001970_abnormal_pain_threshold | 0.99734424 |
| 69 | MP0005332_abnormal_amino_acid | 0.99524998 |
| 70 | MP0003786_premature_aging | 0.99491711 |
| 71 | MP0002572_abnormal_emotion/affect_behav | 0.97914434 |
| 72 | MP0000049_abnormal_middle_ear | 0.97903839 |
| 73 | MP0002064_seizures | 0.97075238 |
| 74 | MP0003646_muscle_fatigue | 0.96164578 |
| 75 | MP0002751_abnormal_autonomic_nervous | 0.95840958 |
| 76 | MP0002733_abnormal_thermal_nociception | 0.95234392 |
| 77 | MP0009697_abnormal_copulation | 0.93287756 |
| 78 | MP0005195_abnormal_posterior_eye | 0.92569484 |
| 79 | MP0000026_abnormal_inner_ear | 0.92458606 |
| 80 | MP0004742_abnormal_vestibular_system | 0.92412735 |
| 81 | MP0003122_maternal_imprinting | 0.90891969 |
| 82 | MP0005423_abnormal_somatic_nervous | 0.90292732 |
| 83 | MP0005394_taste/olfaction_phenotype | 0.89609746 |
| 84 | MP0005499_abnormal_olfactory_system | 0.89609746 |
| 85 | MP0003938_abnormal_ear_development | 0.88546115 |
| 86 | MP0002752_abnormal_somatic_nervous | 0.88504237 |
| 87 | MP0005171_absent_coat_pigmentation | 0.87943374 |
| 88 | MP0000569_abnormal_digit_pigmentation | 0.85544474 |
| 89 | MP0001324_abnormal_eye_pigmentation | 0.84810380 |
| 90 | MP0002734_abnormal_mechanical_nocicepti | 0.83730338 |
| 91 | MP0002210_abnormal_sex_determination | 0.83387192 |
| 92 | MP0004924_abnormal_behavior | 0.82203200 |
| 93 | MP0005386_behavior/neurological_phenoty | 0.82203200 |
| 94 | MP0005391_vision/eye_phenotype | 0.82101231 |
| 95 | MP0002184_abnormal_innervation | 0.82000276 |
| 96 | MP0002067_abnormal_sensory_capabilities | 0.79906996 |
| 97 | MP0002282_abnormal_trachea_morphology | 0.79630895 |
| 98 | MP0005410_abnormal_fertilization | 0.78495152 |
| 99 | MP0003137_abnormal_impulse_conducting | 0.77783309 |
| 100 | MP0001919_abnormal_reproductive_system | 0.76716699 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.02725928 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.75307192 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.53994735 |
| 4 | Increased hepatocellular lipid droplets (HP:0006565) | 4.43602900 |
| 5 | Acute encephalopathy (HP:0006846) | 4.43388038 |
| 6 | Progressive macrocephaly (HP:0004481) | 4.27978654 |
| 7 | Increased CSF lactate (HP:0002490) | 4.21524356 |
| 8 | Lipid accumulation in hepatocytes (HP:0006561) | 4.19583407 |
| 9 | Hepatocellular necrosis (HP:0001404) | 3.90398311 |
| 10 | Renal Fanconi syndrome (HP:0001994) | 3.82465975 |
| 11 | 3-Methylglutaconic aciduria (HP:0003535) | 3.72881215 |
| 12 | Hepatic necrosis (HP:0002605) | 3.69178423 |
| 13 | Pancreatic cysts (HP:0001737) | 3.53089907 |
| 14 | Abnormal number of erythroid precursors (HP:0012131) | 3.39987216 |
| 15 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.33157764 |
| 16 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.33157764 |
| 17 | Abnormality of midbrain morphology (HP:0002418) | 3.27015376 |
| 18 | Molar tooth sign on MRI (HP:0002419) | 3.27015376 |
| 19 | Increased intramyocellular lipid droplets (HP:0012240) | 3.26771471 |
| 20 | Cerebral edema (HP:0002181) | 3.26612883 |
| 21 | Pancreatic fibrosis (HP:0100732) | 3.24719019 |
| 22 | True hermaphroditism (HP:0010459) | 3.19331768 |
| 23 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.17553318 |
| 24 | Nephronophthisis (HP:0000090) | 3.01309742 |
| 25 | Exertional dyspnea (HP:0002875) | 2.93244122 |
| 26 | Lactic acidosis (HP:0003128) | 2.85461461 |
| 27 | Methylmalonic acidemia (HP:0002912) | 2.85426710 |
| 28 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.81208292 |
| 29 | Optic disc pallor (HP:0000543) | 2.77607854 |
| 30 | Congenital, generalized hypertrichosis (HP:0004540) | 2.77383565 |
| 31 | Medial flaring of the eyebrow (HP:0010747) | 2.77057242 |
| 32 | Increased muscle lipid content (HP:0009058) | 2.76195562 |
| 33 | Increased serum lactate (HP:0002151) | 2.70852269 |
| 34 | Methylmalonic aciduria (HP:0012120) | 2.68346268 |
| 35 | Reticulocytopenia (HP:0001896) | 2.64709504 |
| 36 | Respiratory failure (HP:0002878) | 2.58717421 |
| 37 | Abnormality of renal resorption (HP:0011038) | 2.55286006 |
| 38 | Macrocytic anemia (HP:0001972) | 2.54093433 |
| 39 | Type II lissencephaly (HP:0007260) | 2.45344249 |
| 40 | Exercise intolerance (HP:0003546) | 2.43470428 |
| 41 | Abnormality of urine glucose concentration (HP:0011016) | 2.41802228 |
| 42 | Glycosuria (HP:0003076) | 2.41802228 |
| 43 | Congenital stationary night blindness (HP:0007642) | 2.39091648 |
| 44 | Abnormality of the renal medulla (HP:0100957) | 2.35413133 |
| 45 | Sclerocornea (HP:0000647) | 2.33983157 |
| 46 | Type I transferrin isoform profile (HP:0003642) | 2.30628155 |
| 47 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.30506562 |
| 48 | Lethargy (HP:0001254) | 2.27569769 |
| 49 | Hypothermia (HP:0002045) | 2.23350925 |
| 50 | Leukodystrophy (HP:0002415) | 2.21381655 |
| 51 | Gait imbalance (HP:0002141) | 2.20698991 |
| 52 | Respiratory difficulties (HP:0002880) | 2.17368936 |
| 53 | Congenital primary aphakia (HP:0007707) | 2.15591835 |
| 54 | Abnormality of the renal cortex (HP:0011035) | 2.11061054 |
| 55 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.07468506 |
| 56 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.06451096 |
| 57 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.06451096 |
| 58 | Pendular nystagmus (HP:0012043) | 2.05574959 |
| 59 | Large for gestational age (HP:0001520) | 2.01457388 |
| 60 | Renal cortical cysts (HP:0000803) | 2.00928461 |
| 61 | Colon cancer (HP:0003003) | 2.00104937 |
| 62 | Hyperglycinemia (HP:0002154) | 1.99481574 |
| 63 | Nephrogenic diabetes insipidus (HP:0009806) | 1.98537127 |
| 64 | Abnormal protein glycosylation (HP:0012346) | 1.98259505 |
| 65 | Abnormal glycosylation (HP:0012345) | 1.98259505 |
| 66 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.98259505 |
| 67 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.98259505 |
| 68 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.98148112 |
| 69 | Generalized aminoaciduria (HP:0002909) | 1.97699558 |
| 70 | Abnormality of the pons (HP:0007361) | 1.97605596 |
| 71 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.97171891 |
| 72 | Anencephaly (HP:0002323) | 1.96838700 |
| 73 | Hypoplasia of the pons (HP:0012110) | 1.96689188 |
| 74 | Cystic liver disease (HP:0006706) | 1.92460792 |
| 75 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.91903632 |
| 76 | Abnormality of alanine metabolism (HP:0010916) | 1.91903632 |
| 77 | Hyperalaninemia (HP:0003348) | 1.91903632 |
| 78 | Abnormal ciliary motility (HP:0012262) | 1.89943467 |
| 79 | Male pseudohermaphroditism (HP:0000037) | 1.89521747 |
| 80 | Hyperphosphaturia (HP:0003109) | 1.88951496 |
| 81 | Absent thumb (HP:0009777) | 1.81197680 |
| 82 | Abolished electroretinogram (ERG) (HP:0000550) | 1.80022458 |
| 83 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.79476385 |
| 84 | Absent/shortened dynein arms (HP:0200106) | 1.79476385 |
| 85 | Attenuation of retinal blood vessels (HP:0007843) | 1.79238264 |
| 86 | Retinal dysplasia (HP:0007973) | 1.79064888 |
| 87 | Rhinitis (HP:0012384) | 1.77799983 |
| 88 | CNS demyelination (HP:0007305) | 1.77640434 |
| 89 | Genital tract atresia (HP:0001827) | 1.77095045 |
| 90 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.76801955 |
| 91 | Dicarboxylic aciduria (HP:0003215) | 1.76801955 |
| 92 | Septo-optic dysplasia (HP:0100842) | 1.76271355 |
| 93 | Concave nail (HP:0001598) | 1.76206730 |
| 94 | Vaginal atresia (HP:0000148) | 1.75877907 |
| 95 | Focal motor seizures (HP:0011153) | 1.74353474 |
| 96 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.73547541 |
| 97 | Pallor (HP:0000980) | 1.72983302 |
| 98 | X-linked dominant inheritance (HP:0001423) | 1.72529361 |
| 99 | Furrowed tongue (HP:0000221) | 1.71916563 |
| 100 | Abnormality of vitamin B metabolism (HP:0004340) | 1.70173452 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 3.93993491 |
| 2 | ZAK | 3.24675708 |
| 3 | MAP4K2 | 2.99689912 |
| 4 | FRK | 2.65444768 |
| 5 | STK16 | 2.46568735 |
| 6 | TLK1 | 2.46324581 |
| 7 | NUAK1 | 2.42593071 |
| 8 | VRK1 | 2.25698007 |
| 9 | WNK3 | 2.21919315 |
| 10 | ADRBK2 | 2.19028155 |
| 11 | BUB1 | 2.16612703 |
| 12 | BCKDK | 2.13475116 |
| 13 | BMPR1B | 2.06106554 |
| 14 | GRK1 | 1.88062532 |
| 15 | TNIK | 1.82626950 |
| 16 | CASK | 1.75579712 |
| 17 | NME1 | 1.75429196 |
| 18 | DYRK2 | 1.62509190 |
| 19 | PINK1 | 1.54869666 |
| 20 | MAP3K4 | 1.53107988 |
| 21 | WNK4 | 1.51942974 |
| 22 | SRPK1 | 1.46553456 |
| 23 | MAPK13 | 1.38155967 |
| 24 | MAP2K7 | 1.37386489 |
| 25 | MST4 | 1.35046583 |
| 26 | PHKG2 | 1.34933410 |
| 27 | PHKG1 | 1.34933410 |
| 28 | TRIM28 | 1.34193217 |
| 29 | TAF1 | 1.29307578 |
| 30 | INSRR | 1.26853138 |
| 31 | PLK3 | 1.16654230 |
| 32 | TXK | 1.15263285 |
| 33 | PNCK | 1.14099240 |
| 34 | MARK1 | 1.13022857 |
| 35 | CDC7 | 1.11669727 |
| 36 | TAOK3 | 1.11357981 |
| 37 | OBSCN | 1.03394143 |
| 38 | PBK | 0.98812820 |
| 39 | DYRK3 | 0.97783782 |
| 40 | CCNB1 | 0.97405084 |
| 41 | WEE1 | 0.96752393 |
| 42 | CSNK1G2 | 0.96066203 |
| 43 | OXSR1 | 0.94206805 |
| 44 | CSNK1G3 | 0.92820271 |
| 45 | PRKCG | 0.90581964 |
| 46 | PLK4 | 0.89243381 |
| 47 | TIE1 | 0.86343381 |
| 48 | BRSK2 | 0.85249705 |
| 49 | PLK2 | 0.84043160 |
| 50 | MAPK15 | 0.83289816 |
| 51 | RPS6KA5 | 0.83135879 |
| 52 | ACVR1B | 0.81728163 |
| 53 | NEK1 | 0.81637650 |
| 54 | CSNK1G1 | 0.81221520 |
| 55 | LIMK1 | 0.80599495 |
| 56 | PDK2 | 0.79786158 |
| 57 | MKNK1 | 0.78827652 |
| 58 | MUSK | 0.78527529 |
| 59 | STK39 | 0.78397780 |
| 60 | CDK8 | 0.78200651 |
| 61 | PAK3 | 0.77895362 |
| 62 | EIF2AK3 | 0.76743597 |
| 63 | ADRBK1 | 0.73054347 |
| 64 | PIM2 | 0.72518990 |
| 65 | MAPKAPK5 | 0.72477797 |
| 66 | PRKCE | 0.70184049 |
| 67 | CDK19 | 0.69693311 |
| 68 | MKNK2 | 0.68838955 |
| 69 | PLK1 | 0.68805131 |
| 70 | PASK | 0.68615053 |
| 71 | MAP2K6 | 0.68411908 |
| 72 | MAP3K12 | 0.62475478 |
| 73 | ERBB3 | 0.59674212 |
| 74 | FGFR2 | 0.59052949 |
| 75 | PRKCI | 0.58717512 |
| 76 | CSNK1A1L | 0.58474167 |
| 77 | CHEK2 | 0.55519834 |
| 78 | TGFBR1 | 0.54177154 |
| 79 | PKN1 | 0.53061283 |
| 80 | CSNK2A1 | 0.50808726 |
| 81 | CSNK2A2 | 0.49324074 |
| 82 | CAMKK2 | 0.48360359 |
| 83 | EIF2AK2 | 0.47928780 |
| 84 | AURKB | 0.47683522 |
| 85 | DAPK2 | 0.47583895 |
| 86 | PRKACA | 0.46921220 |
| 87 | ATR | 0.46769747 |
| 88 | GRK5 | 0.44637172 |
| 89 | CDK3 | 0.42962618 |
| 90 | NME2 | 0.42202260 |
| 91 | CAMK2A | 0.41964217 |
| 92 | KDR | 0.41756579 |
| 93 | CSNK1A1 | 0.41621465 |
| 94 | EPHB2 | 0.41170515 |
| 95 | AURKA | 0.40907835 |
| 96 | STK38L | 0.40793348 |
| 97 | TTK | 0.40711961 |
| 98 | IKBKB | 0.38082057 |
| 99 | EPHA4 | 0.36706999 |
| 100 | EIF2AK1 | 0.36027849 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.84263003 |
| 2 | Parkinsons disease_Homo sapiens_hsa05012 | 4.08731413 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 4.02928634 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 3.04162876 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.99579330 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 2.83838987 |
| 7 | Alzheimers disease_Homo sapiens_hsa05010 | 2.74875364 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.67514497 |
| 9 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.42573312 |
| 10 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.18019010 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.17963217 |
| 12 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.99283232 |
| 13 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.91310065 |
| 14 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.84507243 |
| 15 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.55897999 |
| 16 | Mismatch repair_Homo sapiens_hsa03430 | 1.53700410 |
| 17 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.52809370 |
| 18 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.51576650 |
| 19 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.48695622 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.45899079 |
| 21 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.43903848 |
| 22 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.41610842 |
| 23 | Phototransduction_Homo sapiens_hsa04744 | 1.34199245 |
| 24 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.32947818 |
| 25 | RNA degradation_Homo sapiens_hsa03018 | 1.32166092 |
| 26 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.30543087 |
| 27 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.28955385 |
| 28 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.26443099 |
| 29 | DNA replication_Homo sapiens_hsa03030 | 1.19965119 |
| 30 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.18554475 |
| 31 | Peroxisome_Homo sapiens_hsa04146 | 1.12962979 |
| 32 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.10488460 |
| 33 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.10328184 |
| 34 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.10322933 |
| 35 | Spliceosome_Homo sapiens_hsa03040 | 1.09995140 |
| 36 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.09682493 |
| 37 | Base excision repair_Homo sapiens_hsa03410 | 1.08279988 |
| 38 | Purine metabolism_Homo sapiens_hsa00230 | 1.07970531 |
| 39 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.06579018 |
| 40 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.05442424 |
| 41 | Sulfur relay system_Homo sapiens_hsa04122 | 1.05408343 |
| 42 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.00994018 |
| 43 | Nicotine addiction_Homo sapiens_hsa05033 | 0.97702253 |
| 44 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.91419357 |
| 45 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.89962800 |
| 46 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.89437452 |
| 47 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.89373616 |
| 48 | Metabolic pathways_Homo sapiens_hsa01100 | 0.88626743 |
| 49 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.88301224 |
| 50 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.86489779 |
| 51 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.84165459 |
| 52 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.82861736 |
| 53 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.82788024 |
| 54 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.80861232 |
| 55 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.80644120 |
| 56 | RNA transport_Homo sapiens_hsa03013 | 0.79221279 |
| 57 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.78776962 |
| 58 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.77539073 |
| 59 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.77228380 |
| 60 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.77209184 |
| 61 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.73210336 |
| 62 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.71817484 |
| 63 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.70235749 |
| 64 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.67627761 |
| 65 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.67275464 |
| 66 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.66730451 |
| 67 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.64808587 |
| 68 | Retinol metabolism_Homo sapiens_hsa00830 | 0.62537387 |
| 69 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.61618576 |
| 70 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.60059149 |
| 71 | Olfactory transduction_Homo sapiens_hsa04740 | 0.59685686 |
| 72 | Taste transduction_Homo sapiens_hsa04742 | 0.56527359 |
| 73 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.55717334 |
| 74 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.54950116 |
| 75 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.53125619 |
| 76 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.50662522 |
| 77 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.48218519 |
| 78 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.47589062 |
| 79 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.47275893 |
| 80 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.46387639 |
| 81 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.43278955 |
| 82 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.42806631 |
| 83 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.40402156 |
| 84 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.39361840 |
| 85 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.37101587 |
| 86 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.34405692 |
| 87 | GABAergic synapse_Homo sapiens_hsa04727 | 0.33760647 |
| 88 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.32122324 |
| 89 | Morphine addiction_Homo sapiens_hsa05032 | 0.31209189 |
| 90 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.30330516 |
| 91 | Asthma_Homo sapiens_hsa05310 | 0.30209254 |
| 92 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.28126819 |
| 93 | Mineral absorption_Homo sapiens_hsa04978 | 0.27624548 |
| 94 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.26386332 |
| 95 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.25121142 |
| 96 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.24303593 |
| 97 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.23754969 |
| 98 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.23034865 |
| 99 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.22047650 |
| 100 | Circadian rhythm_Homo sapiens_hsa04710 | 0.19868688 |

