C7ORF55-LUC7L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring readthrough transcription between the neighboring C7orf55 (chromosome 7 open reading frame 55) and LUC7L2 (LUC7-like 2) genes on chromosome 7. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.77815012
2COPI coating of Golgi vesicle (GO:0048205)5.29217299
3Golgi transport vesicle coating (GO:0048200)5.29217299
4proline biosynthetic process (GO:0006561)5.04864929
5nuclear pore complex assembly (GO:0051292)4.81616305
6regulation of translational fidelity (GO:0006450)4.63794953
7mitotic chromosome condensation (GO:0007076)4.53673218
8DNA strand elongation involved in DNA replication (GO:0006271)4.44874136
9DNA strand elongation (GO:0022616)4.38052158
10peptidyl-arginine omega-N-methylation (GO:0035247)4.19417347
11NADH metabolic process (GO:0006734)4.18283651
12nuclear pore organization (GO:0006999)4.14971199
13spliceosomal tri-snRNP complex assembly (GO:0000244)3.94630114
14telomere maintenance via semi-conservative replication (GO:0032201)3.84831552
15DNA replication initiation (GO:0006270)3.84504177
16formation of translation preinitiation complex (GO:0001731)3.84295900
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.70396170
18pore complex assembly (GO:0046931)3.69857918
19negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.69675167
20protein maturation by protein folding (GO:0022417)3.68778588
21establishment of integrated proviral latency (GO:0075713)3.66660172
22mitotic nuclear envelope disassembly (GO:0007077)3.60543062
23pentose-phosphate shunt (GO:0006098)3.55171290
24mitochondrial fusion (GO:0008053)3.49371817
25nucleobase-containing small molecule interconversion (GO:0015949)3.47190301
26folic acid-containing compound biosynthetic process (GO:0009396)3.43546494
27peptidyl-arginine N-methylation (GO:0035246)3.43374651
28peptidyl-arginine methylation (GO:0018216)3.43374651
29mitotic sister chromatid segregation (GO:0000070)3.40652949
30nuclear envelope disassembly (GO:0051081)3.39040374
31membrane disassembly (GO:0030397)3.39040374
32regulation of mammary gland epithelial cell proliferation (GO:0033599)3.32468343
33regulation of translational termination (GO:0006449)3.31579983
34tricarboxylic acid cycle (GO:0006099)3.29720740
35DNA topological change (GO:0006265)3.26025897
36proline metabolic process (GO:0006560)3.23055433
37protein localization to chromosome, centromeric region (GO:0071459)3.19758234
38IMP metabolic process (GO:0046040)3.15928778
39histone arginine methylation (GO:0034969)3.15173645
40sister chromatid segregation (GO:0000819)3.14516292
41negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.14212555
42NADPH regeneration (GO:0006740)3.13823021
43ribosome assembly (GO:0042255)3.13017834
44negative regulation of cell size (GO:0045792)3.11788450
45telomere maintenance via recombination (GO:0000722)3.11482653
46IMP biosynthetic process (GO:0006188)3.06914007
47DNA duplex unwinding (GO:0032508)3.06316490
48glucose catabolic process (GO:0006007)3.03790066
49negative regulation of mRNA processing (GO:0050686)3.00001321
50nucleosome disassembly (GO:0006337)2.97067322
51protein-DNA complex disassembly (GO:0032986)2.97067322
52chromosome condensation (GO:0030261)2.95193632
53establishment of viral latency (GO:0019043)2.91780469
54DNA geometric change (GO:0032392)2.88955930
55regulation of RNA export from nucleus (GO:0046831)2.88905633
56nuclear envelope organization (GO:0006998)2.88447072
57regulation of mitotic spindle organization (GO:0060236)2.87815167
58ribosome biogenesis (GO:0042254)2.86712863
593-UTR-mediated mRNA stabilization (GO:0070935)2.85235033
60mitotic recombination (GO:0006312)2.85153511
61oxaloacetate metabolic process (GO:0006107)2.84737505
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.83413804
63viral mRNA export from host cell nucleus (GO:0046784)2.81757203
64gluconeogenesis (GO:0006094)2.80692037
65tRNA aminoacylation for protein translation (GO:0006418)2.80619272
66negative regulation of mRNA metabolic process (GO:1903312)2.76350614
67folic acid metabolic process (GO:0046655)2.76268606
68DNA conformation change (GO:0071103)2.76053969
69monosaccharide biosynthetic process (GO:0046364)2.75536735
70protein retention in ER lumen (GO:0006621)2.73238730
71dosage compensation (GO:0007549)2.69920851
72snRNA metabolic process (GO:0016073)2.69147483
73mitotic metaphase plate congression (GO:0007080)2.68415130
74mitotic sister chromatid cohesion (GO:0007064)2.68309519
75protein localization to kinetochore (GO:0034501)2.68165767
76protein complex localization (GO:0031503)2.67667419
77tricarboxylic acid metabolic process (GO:0072350)2.66946332
78tRNA aminoacylation (GO:0043039)2.66425631
79amino acid activation (GO:0043038)2.66425631
80maturation of SSU-rRNA (GO:0030490)2.65967822
81glycolytic process (GO:0006096)2.65596921
82hexose biosynthetic process (GO:0019319)2.65176257
83protein export from nucleus (GO:0006611)2.64469422
84histone H2B ubiquitination (GO:0033523)2.64181154
85cellular hyperosmotic response (GO:0071474)2.63729779
86nuclear envelope reassembly (GO:0031468)2.62916317
87mitotic nuclear envelope reassembly (GO:0007084)2.62916317
88cellular protein complex localization (GO:0034629)2.61774225
89positive regulation of nuclease activity (GO:0032075)2.59824152
90regulation of nucleobase-containing compound transport (GO:0032239)2.58840998
91peptidyl-lysine dimethylation (GO:0018027)2.58108634
92ribonucleoprotein complex biogenesis (GO:0022613)2.56983677
93regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.55241178
94RNA stabilization (GO:0043489)2.54543044
95mRNA stabilization (GO:0048255)2.54543044
96regulation of glucose import in response to insulin stimulus (GO:2001273)2.52882092
97activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.52399909
98positive regulation of DNA-dependent DNA replication (GO:2000105)2.51874063
99tetrahydrofolate metabolic process (GO:0046653)2.51388494
100negative regulation of RNA splicing (GO:0033119)2.50897654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.59691679
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82003312
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.32478829
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.15237587
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.75507217
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.64240010
7MYC_22102868_ChIP-Seq_BL_Human2.60070736
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.56937044
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42849352
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.24718741
11ZNF263_19887448_ChIP-Seq_K562_Human2.21705992
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20827326
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15421190
14XRN2_22483619_ChIP-Seq_HELA_Human2.15268623
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.12061030
16ZFX_18555785_ChIP-Seq_MESCs_Mouse2.06694487
17CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.04392342
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02517827
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01539164
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01374633
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98422726
22AR_21909140_ChIP-Seq_LNCAP_Human1.95408050
23VDR_21846776_ChIP-Seq_THP-1_Human1.91501874
24CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.88838100
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87124199
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86958561
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.86820703
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85584307
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69618034
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68006412
31DCP1A_22483619_ChIP-Seq_HELA_Human1.67373412
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59927672
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.59759471
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59224195
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57689963
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55873835
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.54078137
38KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50956188
39CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50239435
40CLOCK_20551151_ChIP-Seq_293T_Human1.50093750
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48051933
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47392581
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46697826
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.46294118
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44518774
46GABP_19822575_ChIP-Seq_HepG2_Human1.43350684
47TTF2_22483619_ChIP-Seq_HELA_Human1.40055036
48KDM5A_27292631_Chip-Seq_BREAST_Human1.39021228
49HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.38038233
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37824921
51LXR_22292898_ChIP-Seq_THP-1_Human1.36983597
52TFEB_21752829_ChIP-Seq_HELA_Human1.36912137
53BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36601454
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35949115
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34393269
56CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.34195106
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33046366
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33045093
59CIITA_25753668_ChIP-Seq_RAJI_Human1.33017357
60RACK7_27058665_Chip-Seq_MCF-7_Human1.32884988
61ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30830203
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29834469
63SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.29101253
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24890081
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24436972
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.23475376
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20998475
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17640112
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16891812
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16535041
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16421339
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15958828
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15955246
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.15306011
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15023226
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14573601
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13593264
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12127157
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09523161
80CHD1_26751641_Chip-Seq_LNCaP_Human1.09476783
81TCF7_22412390_ChIP-Seq_EML_Mouse1.09390598
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09388338
83FOXP3_21729870_ChIP-Seq_TREG_Human1.07058508
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06992459
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06825057
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.06337268
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05438200
88TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05143110
89NCOR1_26117541_ChIP-Seq_K562_Human1.03158154
90ATF3_27146783_Chip-Seq_COLON_Human1.02664778
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.02645586
92NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99687444
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98608578
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98163240
95EST1_17652178_ChIP-ChIP_JURKAT_Human0.98013289
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97861395
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96321789
98MAF_26560356_Chip-Seq_TH1_Human0.94895178
99SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94426109
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92713542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.71131218
2MP0010094_abnormal_chromosome_stability3.44266393
3MP0003111_abnormal_nucleus_morphology3.30954406
4MP0003693_abnormal_embryo_hatching2.95907079
5MP0003705_abnormal_hypodermis_morpholog2.87071869
6MP0004233_abnormal_muscle_weight2.75840196
7MP0002877_abnormal_melanocyte_morpholog2.71235491
8MP0004957_abnormal_blastocyst_morpholog2.69454370
9MP0003077_abnormal_cell_cycle2.61275749
10MP0000751_myopathy2.48635825
11MP0001730_embryonic_growth_arrest2.35192534
12MP0000747_muscle_weakness2.16180078
13MP0004185_abnormal_adipocyte_glucose2.12739121
14MP0008932_abnormal_embryonic_tissue2.04538778
15MP0008057_abnormal_DNA_replication2.01858589
16MP0008058_abnormal_DNA_repair1.91780804
17MP0000350_abnormal_cell_proliferation1.87517661
18MP0010234_abnormal_vibrissa_follicle1.87020088
19MP0001661_extended_life_span1.81206822
20MP0002009_preneoplasia1.80063742
21MP0002396_abnormal_hematopoietic_system1.79535647
22MP0005058_abnormal_lysosome_morphology1.77083884
23MP0000759_abnormal_skeletal_muscle1.74075720
24MP0005330_cardiomyopathy1.73861842
25MP0000749_muscle_degeneration1.72500501
26MP0004087_abnormal_muscle_fiber1.70411171
27MP0005623_abnormal_meninges_morphology1.67848772
28MP0002269_muscular_atrophy1.64733585
29MP0008007_abnormal_cellular_replicative1.60866559
30MP0003566_abnormal_cell_adhesion1.59892846
31MP0002080_prenatal_lethality1.59357458
32MP0009672_abnormal_birth_weight1.55855063
33MP0005076_abnormal_cell_differentiation1.52943900
34MP0010352_gastrointestinal_tract_polyps1.51287985
35MP0000003_abnormal_adipose_tissue1.48255320
36MP0003221_abnormal_cardiomyocyte_apopto1.45016409
37MP0001672_abnormal_embryogenesis/_devel1.44911534
38MP0005380_embryogenesis_phenotype1.44911534
39MP0000733_abnormal_muscle_development1.42075818
40MP0003984_embryonic_growth_retardation1.41771007
41MP0008260_abnormal_autophagy1.37886057
42MP0000313_abnormal_cell_death1.35947340
43MP0004808_abnormal_hematopoietic_stem1.35478714
44MP0000537_abnormal_urethra_morphology1.34012607
45MP0004036_abnormal_muscle_relaxation1.33268012
46MP0004145_abnormal_muscle_electrophysio1.30834441
47MP0002088_abnormal_embryonic_growth/wei1.30713417
48MP0001697_abnormal_embryo_size1.29674833
49MP0009697_abnormal_copulation1.29628084
50MP0008438_abnormal_cutaneous_collagen1.29506896
51MP0001849_ear_inflammation1.29499380
52MP0006036_abnormal_mitochondrial_physio1.28910183
53MP0010630_abnormal_cardiac_muscle1.24721013
54MP0005666_abnormal_adipose_tissue1.23933728
55MP0002166_altered_tumor_susceptibility1.16772636
56MP0001727_abnormal_embryo_implantation1.16136884
57MP0000750_abnormal_muscle_regeneration1.15133625
58MP0003656_abnormal_erythrocyte_physiolo1.14622361
59MP0005375_adipose_tissue_phenotype1.14208865
60MP0005621_abnormal_cell_physiology1.10681784
61MP0001348_abnormal_lacrimal_gland1.08552664
62MP0003806_abnormal_nucleotide_metabolis1.07805348
63MP0001346_abnormal_lacrimal_gland1.07662369
64MP0002106_abnormal_muscle_physiology1.05798763
65MP0002086_abnormal_extraembryonic_tissu1.05410778
66MP0010307_abnormal_tumor_latency1.00120237
67MP0002085_abnormal_embryonic_tissue0.99886645
68MP0003315_abnormal_perineum_morphology0.99794507
69MP0005384_cellular_phenotype0.97925250
70MP0006035_abnormal_mitochondrial_morpho0.96998469
71MP0000358_abnormal_cell_content/0.96788189
72MP0000678_abnormal_parathyroid_gland0.96558502
73MP0004272_abnormal_basement_membrane0.93008941
74MP0002084_abnormal_developmental_patter0.92140813
75MP0002019_abnormal_tumor_incidence0.90904804
76MP0004197_abnormal_fetal_growth/weight/0.90136867
77MP0000490_abnormal_crypts_of0.89490681
78MP0004858_abnormal_nervous_system0.89032535
79MP0005369_muscle_phenotype0.87544607
80MP0009333_abnormal_splenocyte_physiolog0.87234728
81MP0009840_abnormal_foam_cell0.85867255
82MP0003786_premature_aging0.84128753
83MP0005220_abnormal_exocrine_pancreas0.81813731
84MP0000013_abnormal_adipose_tissue0.81034555
85MP0005501_abnormal_skin_physiology0.80948238
86MP0002006_tumorigenesis0.78295485
87MP0004084_abnormal_cardiac_muscle0.76592171
88MP0006138_congestive_heart_failure0.75790981
89MP0001915_intracranial_hemorrhage0.75716745
90MP0009278_abnormal_bone_marrow0.75140640
91MP0002060_abnormal_skin_morphology0.73627508
92MP0001881_abnormal_mammary_gland0.71371380
93MP0002089_abnormal_postnatal_growth/wei0.70427240
94MP0002970_abnormal_white_adipose0.69987439
95MP0003191_abnormal_cellular_cholesterol0.68602930
96MP0009703_decreased_birth_body0.67305774
97MP0003646_muscle_fatigue0.67264976
98MP0005257_abnormal_intraocular_pressure0.67063085
99MP0003091_abnormal_cell_migration0.65384226
100MP0000598_abnormal_liver_morphology0.64285649

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)3.88766535
2Progressive muscle weakness (HP:0003323)3.78952239
3Centrally nucleated skeletal muscle fibers (HP:0003687)3.67000508
4Nemaline bodies (HP:0003798)3.55968940
5Muscle fiber inclusion bodies (HP:0100299)3.53094191
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.49738625
7Hyperacusis (HP:0010780)3.42320721
8Myopathic facies (HP:0002058)3.37019462
9Rhabdomyolysis (HP:0003201)3.23585965
10Increased connective tissue (HP:0009025)3.23355248
11Ragged-red muscle fibers (HP:0003200)3.19216071
12Abnormal gallbladder physiology (HP:0012438)3.01028913
13Cholecystitis (HP:0001082)3.01028913
14Myoglobinuria (HP:0002913)2.92838320
15Type 1 muscle fiber predominance (HP:0003803)2.83229014
16Abnormality of glycolysis (HP:0004366)2.78705396
17Distal lower limb amyotrophy (HP:0008944)2.77388482
18Achilles tendon contracture (HP:0001771)2.74875135
19Abnormality of skeletal muscle fiber size (HP:0012084)2.71828605
20Back pain (HP:0003418)2.69966322
21Insomnia (HP:0100785)2.63537122
22Abnormality of the Achilles tendon (HP:0005109)2.61089893
23Exercise-induced muscle cramps (HP:0003710)2.60594780
24Distal lower limb muscle weakness (HP:0009053)2.60325682
25Vertebral compression fractures (HP:0002953)2.50404604
26Increased variability in muscle fiber diameter (HP:0003557)2.47908680
27Abnormality of the calcaneus (HP:0008364)2.42232717
28Calcaneovalgus deformity (HP:0001848)2.41588958
29Trismus (HP:0000211)2.38587233
30Spinal rigidity (HP:0003306)2.33810570
31EMG: myopathic abnormalities (HP:0003458)2.32443285
32Microvesicular hepatic steatosis (HP:0001414)2.30917265
33Orthostatic hypotension (HP:0001278)2.30323637
34Progressive external ophthalmoplegia (HP:0000590)2.28596310
35Increased serum pyruvate (HP:0003542)2.27101342
36Muscle stiffness (HP:0003552)2.25104757
37Reticulocytosis (HP:0001923)2.24013644
38Septate vagina (HP:0001153)2.23394730
39Dysmetric saccades (HP:0000641)2.22034153
40Cholelithiasis (HP:0001081)2.18053212
41Round ear (HP:0100830)2.14009900
42Ulnar deviation of the wrist (HP:0003049)2.13586021
43Deformed tarsal bones (HP:0008119)2.05223339
44Abnormality of the umbilical cord (HP:0010881)1.96103492
45Fatigue (HP:0012378)1.95868116
46Rimmed vacuoles (HP:0003805)1.95685172
47Abnormality of the tricuspid valve (HP:0001702)1.94504767
48Termporal pattern (HP:0011008)1.91133060
49Insidious onset (HP:0003587)1.91133060
50Overriding aorta (HP:0002623)1.90544587
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.90423440
52Abnormal gallbladder morphology (HP:0012437)1.90196529
53Premature rupture of membranes (HP:0001788)1.89723612
54Shoulder girdle muscle weakness (HP:0003547)1.89114490
55Ulnar bowing (HP:0003031)1.88712614
56Breech presentation (HP:0001623)1.87675547
57Abnormality of the gallbladder (HP:0005264)1.85789068
58Athetosis (HP:0002305)1.85627243
59Increased nuchal translucency (HP:0010880)1.83402230
60Pelvic girdle muscle weakness (HP:0003749)1.82419682
61Sparse lateral eyebrow (HP:0005338)1.80195340
62Neck muscle weakness (HP:0000467)1.79520160
63Progressive hearing impairment (HP:0001730)1.78435334
64Protrusio acetabuli (HP:0003179)1.77983591
65Metatarsus adductus (HP:0001840)1.77473868
66Asymmetry of the thorax (HP:0001555)1.76717587
67Hyporeflexia of lower limbs (HP:0002600)1.76435833
68Abnormality of the left ventricular outflow tract (HP:0011103)1.76334108
69Subaortic stenosis (HP:0001682)1.76334108
70Broad distal phalanx of finger (HP:0009836)1.75752390
71Generalized amyotrophy (HP:0003700)1.74322082
72Difficulty climbing stairs (HP:0003551)1.73506582
73Multiple enchondromatosis (HP:0005701)1.73451853
74Deviation of the thumb (HP:0009603)1.72278077
75Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72267255
76Abnormality of reticulocytes (HP:0004312)1.71766979
77Long palpebral fissure (HP:0000637)1.71046611
78Proximal placement of thumb (HP:0009623)1.70622877
79Broad face (HP:0000283)1.70320220
80Impaired pain sensation (HP:0007328)1.69457303
81Abnormality of pain sensation (HP:0010832)1.69457303
82Flat acetabular roof (HP:0003180)1.67031588
83Unilateral renal agenesis (HP:0000122)1.66116621
84Elfin facies (HP:0004428)1.65055787
85Truncus arteriosus (HP:0001660)1.64301821
86Adducted thumb (HP:0001181)1.63872094
87Premature skin wrinkling (HP:0100678)1.63802833
88Distal arthrogryposis (HP:0005684)1.63743479
89Patellar dislocation (HP:0002999)1.63254687
90Lower limb amyotrophy (HP:0007210)1.62944675
91Hypokinesia (HP:0002375)1.61769708
92Asymmetric septal hypertrophy (HP:0001670)1.60915893
93Abnormality of the distal phalanges of the toes (HP:0010182)1.58893648
94Mildly elevated creatine phosphokinase (HP:0008180)1.58662435
95Abnormal umbilical cord blood vessels (HP:0011403)1.58363509
96Single umbilical artery (HP:0001195)1.58363509
97Abnormality of the fetal cardiovascular system (HP:0010948)1.58363509
98Testicular atrophy (HP:0000029)1.58176019
99Selective tooth agenesis (HP:0001592)1.58077933
100Abnormalities of placenta or umbilical cord (HP:0001194)1.57168569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.09715788
2EEF2K3.92438572
3SMG13.90892665
4ICK2.72388608
5IRAK32.71601646
6CDK122.61043827
7SCYL22.60817759
8TTN2.43570973
9EIF2AK12.39668885
10NME22.36396542
11PRPF4B2.01531500
12NEK12.01100285
13ERN11.96321532
14TESK21.86784809
15VRK21.86265599
16BUB11.80238803
17CDC71.71539432
18TTK1.70557736
19SRPK11.63728301
20MAP3K101.56283205
21RPS6KB21.45569396
22PIM21.39050022
23ARAF1.37071559
24CDK71.26772615
25PAK41.23251683
26TSSK61.20286538
27SIK11.19151450
28TESK11.14432966
29MAP2K31.10545857
30OBSCN1.08897842
31BCKDK1.06602746
32FGFR41.05708516
33MAP3K81.05464561
34CDK41.05091404
35EPHA21.04336969
36PKN21.03523235
37AURKA0.99670273
38BRAF0.99556258
39MTOR0.99431957
40TAOK20.97963801
41PHKG20.95293314
42PHKG10.95293314
43CCNB10.94459234
44CHEK20.92685134
45PBK0.92543174
46MAPK110.88938915
47AKT20.88526338
48KSR20.87416447
49NEK90.85974738
50AURKB0.83566545
51ATR0.82787204
52CHEK10.81866464
53PRKD30.78079923
54RAF10.77660918
55CDK60.77609061
56MAP3K130.76820281
57PDGFRA0.74713153
58RIPK10.71949579
59ILK0.70894100
60LRRK20.67378910
61CLK10.67086773
62BRSK10.65025817
63CAMK1G0.61304483
64CDK80.60274360
65LATS20.58117480
66CAMK1D0.57734624
67PAK20.57638066
68PASK0.56565682
69KDR0.55974161
70CDK90.55016591
71CDK20.54871003
72BRD40.54738497
73LMTK20.54543162
74DAPK10.54084040
75MAP2K20.53083477
76EIF2AK30.50783108
77STK40.50502135
78PLK40.48528337
79RPS6KA40.48353111
80VRK10.47877657
81PLK10.47212155
82CDK10.46381831
83NEK20.46026046
84MAPKAPK30.45830677
85DAPK30.45330779
86TBK10.42889543
87PTK60.42744271
88STK100.42606847
89ALK0.42449585
90MST1R0.40445399
91MOS0.38648496
92CDK11A0.38108477
93CDK150.37809265
94PDPK10.37420407
95ATM0.37135006
96TAOK10.36943399
97MAP3K110.35916588
98CSNK2A20.35807560
99BMX0.34022187
100PAK10.33590350

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.05547181
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.62921129
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.04360844
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.95175575
5Biosynthesis of amino acids_Homo sapiens_hsa012302.60350443
6Base excision repair_Homo sapiens_hsa034102.55909971
7Pentose phosphate pathway_Homo sapiens_hsa000302.49553803
8Mismatch repair_Homo sapiens_hsa034302.37843227
9Carbon metabolism_Homo sapiens_hsa012002.36847017
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.19600704
11Spliceosome_Homo sapiens_hsa030402.14729787
12One carbon pool by folate_Homo sapiens_hsa006701.91689035
13Fructose and mannose metabolism_Homo sapiens_hsa000511.87121868
14Nucleotide excision repair_Homo sapiens_hsa034201.81395969
15Non-homologous end-joining_Homo sapiens_hsa034501.81288165
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77959343
17Cell cycle_Homo sapiens_hsa041101.76902141
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.71934945
19RNA transport_Homo sapiens_hsa030131.70763917
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.54924941
21Pyruvate metabolism_Homo sapiens_hsa006201.48219948
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44900905
23Chronic myeloid leukemia_Homo sapiens_hsa052201.40142849
24Pyrimidine metabolism_Homo sapiens_hsa002401.38294999
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34372950
26Other glycan degradation_Homo sapiens_hsa005111.32402438
27Bladder cancer_Homo sapiens_hsa052191.31967762
28Non-small cell lung cancer_Homo sapiens_hsa052231.26596732
29mRNA surveillance pathway_Homo sapiens_hsa030151.26362942
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25139827
31Sulfur relay system_Homo sapiens_hsa041221.22320354
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.20301735
33Thyroid cancer_Homo sapiens_hsa052161.13135234
34Acute myeloid leukemia_Homo sapiens_hsa052211.07358843
35Pancreatic cancer_Homo sapiens_hsa052121.04695383
36Proteasome_Homo sapiens_hsa030501.02098270
37Fatty acid elongation_Homo sapiens_hsa000621.01560906
38N-Glycan biosynthesis_Homo sapiens_hsa005100.99508238
39Lysine degradation_Homo sapiens_hsa003100.99499858
40Galactose metabolism_Homo sapiens_hsa000520.99175281
41Viral carcinogenesis_Homo sapiens_hsa052030.97934849
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.95657067
43Arginine and proline metabolism_Homo sapiens_hsa003300.93705571
44Fatty acid metabolism_Homo sapiens_hsa012120.93206043
45Insulin signaling pathway_Homo sapiens_hsa049100.93107404
46Arginine biosynthesis_Homo sapiens_hsa002200.91167437
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88894668
48AMPK signaling pathway_Homo sapiens_hsa041520.86490838
49Endometrial cancer_Homo sapiens_hsa052130.86301817
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83826546
51Ribosome_Homo sapiens_hsa030100.83640798
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83177184
53Systemic lupus erythematosus_Homo sapiens_hsa053220.78319363
54Small cell lung cancer_Homo sapiens_hsa052220.78262911
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77355299
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75855240
57Prion diseases_Homo sapiens_hsa050200.75108648
58Prostate cancer_Homo sapiens_hsa052150.68917888
59mTOR signaling pathway_Homo sapiens_hsa041500.67325938
60Phenylalanine metabolism_Homo sapiens_hsa003600.66821617
61Epstein-Barr virus infection_Homo sapiens_hsa051690.66559327
62Homologous recombination_Homo sapiens_hsa034400.65023930
63Glioma_Homo sapiens_hsa052140.64925183
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64742292
65Purine metabolism_Homo sapiens_hsa002300.63436168
66Alcoholism_Homo sapiens_hsa050340.61167729
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59599618
68Apoptosis_Homo sapiens_hsa042100.56830383
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56825329
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55778276
71HTLV-I infection_Homo sapiens_hsa051660.54598589
72Vibrio cholerae infection_Homo sapiens_hsa051100.54149277
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54100170
74Hepatitis B_Homo sapiens_hsa051610.52781598
75Glucagon signaling pathway_Homo sapiens_hsa049220.52465699
76Folate biosynthesis_Homo sapiens_hsa007900.52248652
77RNA polymerase_Homo sapiens_hsa030200.51933264
78Notch signaling pathway_Homo sapiens_hsa043300.50236848
79VEGF signaling pathway_Homo sapiens_hsa043700.49865504
80Glutathione metabolism_Homo sapiens_hsa004800.49415820
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49200614
82MicroRNAs in cancer_Homo sapiens_hsa052060.48920064
83Colorectal cancer_Homo sapiens_hsa052100.48555793
84B cell receptor signaling pathway_Homo sapiens_hsa046620.48197454
85Fatty acid biosynthesis_Homo sapiens_hsa000610.47830671
86Renal cell carcinoma_Homo sapiens_hsa052110.45774893
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45774804
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39427931
89Herpes simplex infection_Homo sapiens_hsa051680.39425970
90Shigellosis_Homo sapiens_hsa051310.38871604
91Insulin resistance_Homo sapiens_hsa049310.38795115
92HIF-1 signaling pathway_Homo sapiens_hsa040660.37650504
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35093766
94Oocyte meiosis_Homo sapiens_hsa041140.34763791
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.34732564
96Propanoate metabolism_Homo sapiens_hsa006400.34270723
97p53 signaling pathway_Homo sapiens_hsa041150.33227755
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.32707993
99Selenocompound metabolism_Homo sapiens_hsa004500.31656279
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31027567

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