ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	left/right pattern formation (GO:0060972)	8.90654585
2	regulation of cilium movement (GO:0003352)	7.93720184
3	ventricular system development (GO:0021591)	7.46414105
4	left/right axis specification (GO:0070986)	7.08055753
5	intraciliary transport (GO:0042073)	6.91237790
6	cilium organization (GO:0044782)	6.44014892
7	cilium assembly (GO:0042384)	6.28116846
8	microtubule bundle formation (GO:0001578)	6.22819454
9	primary alcohol catabolic process (GO:0034310)	5.93377221
10	vitamin transmembrane transport (GO:0035461)	5.74116771
11	negative regulation of inclusion body assembly (GO:0090084)	5.23664286
12	diterpenoid biosynthetic process (GO:0016102)	5.00447500
13	ethanol metabolic process (GO:0006067)	4.99887144
14	protein localization to cilium (GO:0061512)	4.94139839
15	microtubule-based movement (GO:0007018)	4.92846744
16	cellular component assembly involved in morphogenesis (GO:0010927)	4.92347593
17	centriole assembly (GO:0098534)	4.83598060
18	cilium morphogenesis (GO:0060271)	4.67951967
19	lung epithelium development (GO:0060428)	4.67326858
20	regulation of microtubule-based movement (GO:0060632)	4.65195927
21	response to xenobiotic stimulus (GO:0009410)	4.64983514
22	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.61076889
23	one-carbon compound transport (GO:0019755)	4.53348954
24	glomerular epithelial cell development (GO:0072310)	4.51479891
25	cell projection assembly (GO:0030031)	4.44695870
26	tolerance induction (GO:0002507)	4.42114545
27	sperm capacitation (GO:0048240)	4.40110576
28	negative regulation of T cell differentiation in thymus (GO:0033085)	4.27743444
29	negative regulation of immunoglobulin mediated immune response (GO:0002890)	4.05736256
30	negative regulation of B cell mediated immunity (GO:0002713)	4.05736256
31	regulation of interleukin-5 production (GO:0032674)	4.04118803
32	positive regulation of tolerance induction (GO:0002645)	3.99903194
33	establishment of apical/basal cell polarity (GO:0035089)	3.95567842
34	negative regulation of humoral immune response (GO:0002921)	3.91296998
35	establishment of tissue polarity (GO:0007164)	3.72429828
36	establishment of planar polarity (GO:0001736)	3.72429828
37	nucleoside diphosphate phosphorylation (GO:0006165)	3.70183746
38	regulation of germinal center formation (GO:0002634)	3.58861867
39	microtubule depolymerization (GO:0007019)	3.58668328
40	ethanol oxidation (GO:0006069)	3.58273391
41	regulation of interleukin-13 production (GO:0032656)	3.57231368
42	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	3.46979923
43	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.42434745
44	establishment of monopolar cell polarity (GO:0061162)	3.42434745
45	determination of left/right symmetry (GO:0007368)	3.40507933
46	lateral ventricle development (GO:0021670)	3.37291417
47	microtubule polymerization or depolymerization (GO:0031109)	3.35982411
48	retinoic acid metabolic process (GO:0042573)	3.35537581
49	terpenoid biosynthetic process (GO:0016114)	3.34485602
50	cytoplasmic microtubule organization (GO:0031122)	3.34031047
51	positive regulation of smoothened signaling pathway (GO:0045880)	3.28691578
52	smoothened signaling pathway (GO:0007224)	3.28648234
53	determination of bilateral symmetry (GO:0009855)	3.26374148
54	regulation of inclusion body assembly (GO:0090083)	3.25923565
55	specification of symmetry (GO:0009799)	3.21488871
56	retinal rod cell development (GO:0046548)	3.10746974
57	protein refolding (GO:0042026)	3.10334538
58	lateral sprouting from an epithelium (GO:0060601)	3.03644898
59	axonemal dynein complex assembly (GO:0070286)	21.8208915
60	sperm motility (GO:0030317)	2.95085289
61	apical protein localization (GO:0045176)	2.90237033
62	centriole replication (GO:0007099)	2.88660403
63	regulation of tolerance induction (GO:0002643)	2.87105556
64	microtubule-based process (GO:0007017)	2.85627059
65	carnitine metabolic process (GO:0009437)	2.83152933
66	intra-S DNA damage checkpoint (GO:0031573)	2.79214592
67	heart looping (GO:0001947)	2.77367018
68	multicellular organismal water homeostasis (GO:0050891)	2.77249173
69	glutathione derivative metabolic process (GO:1901685)	2.74588630
70	glutathione derivative biosynthetic process (GO:1901687)	2.74588630
71	organelle assembly (GO:0070925)	2.74583668
72	exogenous drug catabolic process (GO:0042738)	2.73253766
73	nonmotile primary cilium assembly (GO:0035058)	2.73092708
74	primary alcohol metabolic process (GO:0034308)	2.66881843
75	retinol metabolic process (GO:0042572)	2.66860300
76	renal system development (GO:0072001)	2.66227444
77	embryonic heart tube morphogenesis (GO:0003143)	2.64263610
78	O-glycan processing (GO:0016266)	2.63025868
79	hydrogen peroxide biosynthetic process (GO:0050665)	2.58532687
80	regulation of smoothened signaling pathway (GO:0008589)	2.56681131
81	asymmetric protein localization (GO:0008105)	2.51426385
82	progesterone metabolic process (GO:0042448)	2.45350185
83	regulation of microtubule depolymerization (GO:0031114)	2.45109397
84	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.41801758
85	iron ion import (GO:0097286)	2.39827332
86	water homeostasis (GO:0030104)	2.37418915
87	aldehyde catabolic process (GO:0046185)	2.36542809
88	phosphatidylcholine biosynthetic process (GO:0006656)	2.35953005
89	polyol transport (GO:0015791)	2.34812680
90	carnitine transmembrane transport (GO:1902603)	2.33695109
91	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.33617362
92	establishment of nucleus localization (GO:0040023)	2.32794415
93	regulation of autophagic vacuole assembly (GO:2000785)	2.32049680
94	neurotransmitter catabolic process (GO:0042135)	2.31227064
95	cilium or flagellum-dependent cell motility (GO:0001539)	18.9610728
96	cilium movement (GO:0003341)	16.6058135
97	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	14.8543753
98	motile cilium assembly (GO:0044458)	14.8170112
99	epithelial cilium movement (GO:0003351)	13.9952438
100	axoneme assembly (GO:0035082)	10.0966927

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.44231286
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.94761358
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.12943317
4	DROSHA_22980978_ChIP-Seq_HELA_Human	3.08627853
5	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.99145743
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.64852966
7	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.22390822
8	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.21933267
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.14751889
10	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.94532103
11	AHR_22903824_ChIP-Seq_MCF-7_Human	1.93987550
12	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.81864597
13	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.80540082
14	TP53_18474530_ChIP-ChIP_U2OS_Human	1.77778985
15	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.77382896
16	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.75696585
17	VDR_22108803_ChIP-Seq_LS180_Human	1.74078494
18	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.73808252
19	TP63_23658742_ChIP-Seq_EP156T_Human	1.71282412
20	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.66056631
21	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.58106358
22	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.58101776
23	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.55331355
24	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.52706895
25	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.48992066
26	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.45979822
27	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.45330544
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44538606
29	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.40598834
30	TP53_16413492_ChIP-PET_HCT116_Human	1.39352000
31	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.38494312
32	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.37719587
33	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.37376945
34	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.36311391
35	KLF5_25053715_ChIP-Seq_YYC3_Human	1.35863214
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.35299598
37	STAT1_20625510_ChIP-Seq_HELA_Human	1.35027086
38	SMC4_20622854_ChIP-Seq_HELA_Human	1.34819606
39	ETV1_20927104_ChIP-Seq_GIST48_Human	1.33155906
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.32324650
41	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.31169632
42	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.30999424
43	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.30840443
44	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.30499908
45	PHF8_20622853_ChIP-Seq_HELA_Human	1.29947999
46	TP63_22573176_ChIP-Seq_HFKS_Human	1.29193244
47	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25510172
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24300322
49	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.22543640
50	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.21603529
51	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.21208313
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.21144309
53	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20489801
54	SOX2_20726797_ChIP-Seq_SW620_Human	1.18840964
55	TBL1_22424771_ChIP-Seq_293T_Human	1.16239120
56	NFYA_21822215_ChIP-Seq_K562_Human	1.14443923
57	* SMRT_27268052_Chip-Seq_Bcells_Human	1.13798536
58	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.13111147
59	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.12814502
60	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.12159577
61	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11976681
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.11099758
63	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.10211582
64	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.09705285
65	STAT3_23295773_ChIP-Seq_U87_Human	1.08297738
66	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.08291898
67	RBPJ_21746931_ChIP-Seq_IB4_Human	1.07800520
68	GATA1_19941826_ChIP-Seq_K562_Human	1.06479627
69	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.06336028
70	NFYB_21822215_ChIP-Seq_K562_Human	1.06273076
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.05751165
72	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.05285498
73	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.04005275
74	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.01232996
75	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00846114
76	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.99439087
77	GATA4_25053715_ChIP-Seq_YYC3_Human	0.98654732
78	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.97827709
79	RXR_22108803_ChIP-Seq_LS180_Human	0.96245988
80	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.95905073
81	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.95799601
82	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.95377439
83	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.95245090
84	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.94791507
85	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.93385295
86	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.92898302
87	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.92047226
88	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.91536431
89	TAF15_26573619_Chip-Seq_HEK293_Human	0.91230574
90	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.90397069
91	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.89417050
92	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.88629009
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.87878183
94	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.87129997
95	ERG_20517297_ChIP-Seq_VCAP_Human	0.87053836
96	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.86787899
97	CBP_21632823_ChIP-Seq_H3396_Human	0.84853357
98	TCF4_23295773_ChIP-Seq_U87_Human	0.84283791
99	AR_19668381_ChIP-Seq_PC3_Human	0.83347109
100	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.83178342

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	7.80331617
2	MP0008875_abnormal_xenobiotic_pharmacok	5.80428876
3	MP0002132_abnormal_respiratory_system	4.37537805
4	MP0005623_abnormal_meninges_morphology	4.20852077
5	MP0001984_abnormal_olfaction	4.19211120
6	MP0004133_heterotaxia	3.63947045
7	MP0002277_abnormal_respiratory_mucosa	3.62937348
8	MP0000566_synostosis	2.98414105
9	MP0000383_abnormal_hair_follicle	2.90770295
10	MP0003136_yellow_coat_color	2.77878846
11	MP0004043_abnormal_pH_regulation	2.76825314
12	MP0002282_abnormal_trachea_morphology	2.63936165
13	MP0009780_abnormal_chondrocyte_physiolo	2.62910602
14	MP0010678_abnormal_skin_adnexa	2.46515699
15	MP0008789_abnormal_olfactory_epithelium	2.38224484
16	MP0005377_hearing/vestibular/ear_phenot	2.05516791
17	MP0003878_abnormal_ear_physiology	2.05516791
18	MP0000569_abnormal_digit_pigmentation	1.83923701
19	MP0004019_abnormal_vitamin_homeostasis	1.69724261
20	MP0003656_abnormal_erythrocyte_physiolo	1.65754709
21	MP0002638_abnormal_pupillary_reflex	1.54152928
22	MP0002249_abnormal_larynx_morphology	1.53550124
23	MP0005394_taste/olfaction_phenotype	1.52310353
24	MP0005499_abnormal_olfactory_system	1.52310353
25	MP0002928_abnormal_bile_duct	1.51253607
26	MP0002909_abnormal_adrenal_gland	1.44303217
27	MP0002168_other_aberrant_phenotype	1.42618441
28	MP0002160_abnormal_reproductive_system	1.41644507
29	MP0003283_abnormal_digestive_organ	1.31748515
30	MP0002822_catalepsy	1.24783197
31	MP0000467_abnormal_esophagus_morphology	1.24585405
32	MP0001485_abnormal_pinna_reflex	1.21827555
33	MP0001765_abnormal_ion_homeostasis	1.17152206
34	MP0002233_abnormal_nose_morphology	1.16296680
35	MP0010234_abnormal_vibrissa_follicle	1.12122592
36	MP0003890_abnormal_embryonic-extraembry	1.12085008
37	MP0002734_abnormal_mechanical_nocicepti	1.12039560
38	MP0005646_abnormal_pituitary_gland	1.11606056
39	MP0009046_muscle_twitch	1.11038369
40	MP0003806_abnormal_nucleotide_metabolis	1.06428140
41	MP0005165_increased_susceptibility_to	1.06318479
42	MP0010030_abnormal_orbit_morphology	1.05114236
43	MP0001346_abnormal_lacrimal_gland	1.04188121
44	MP0000026_abnormal_inner_ear	1.03341547
45	MP0009379_abnormal_foot_pigmentation	1.02120838
46	MP0001293_anophthalmia	1.01160983
47	MP0002098_abnormal_vibrissa_morphology	0.99035944
48	MP0005083_abnormal_biliary_tract	0.95638956
49	MP0001502_abnormal_circadian_rhythm	0.93901496
50	MP0005503_abnormal_tendon_morphology	0.91031840
51	MP0003950_abnormal_plasma_membrane	0.87734229
52	MP0005248_abnormal_Harderian_gland	0.83090784
53	MP0002735_abnormal_chemical_nociception	0.81916242
54	MP0003453_abnormal_keratinocyte_physiol	0.81058919
55	MP0001929_abnormal_gametogenesis	0.80266828
56	MP0000465_gastrointestinal_hemorrhage	0.79912001
57	MP0005395_other_phenotype	0.78177681
58	MP0001299_abnormal_eye_distance/	0.76778016
59	MP0005636_abnormal_mineral_homeostasis	0.75932880
60	MP0005164_abnormal_response_to	0.75375438
61	MP0003943_abnormal_hepatobiliary_system	0.73964585
62	MP0003698_abnormal_male_reproductive	0.73942625
63	MP0003937_abnormal_limbs/digits/tail_de	0.72404658
64	MP0001727_abnormal_embryo_implantation	0.72241377
65	MP0005409_darkened_coat_color	0.70545567
66	MP0008995_early_reproductive_senescence	0.70156636
67	MP0005253_abnormal_eye_physiology	0.70023142
68	MP0002796_impaired_skin_barrier	0.68430672
69	MP0009703_decreased_birth_body	0.67154467
70	MP0000955_abnormal_spinal_cord	0.66678813
71	MP0000678_abnormal_parathyroid_gland	0.66222631
72	MP0005551_abnormal_eye_electrophysiolog	0.65957689
73	MP0005391_vision/eye_phenotype	0.65748883
74	MP0005187_abnormal_penis_morphology	0.65641656
75	MP0005389_reproductive_system_phenotype	0.63647831
76	MP0002876_abnormal_thyroid_physiology	0.63395680
77	MP0001324_abnormal_eye_pigmentation	0.62691546
78	MP0001849_ear_inflammation	0.61076694
79	MP0002092_abnormal_eye_morphology	0.60466820
80	MP0002116_abnormal_craniofacial_bone	0.59617082
81	MP0002136_abnormal_kidney_physiology	0.59603580
82	MP0000631_abnormal_neuroendocrine_gland	0.59402367
83	MP0009053_abnormal_anal_canal	0.59287032
84	MP0002133_abnormal_respiratory_system	0.59193518
85	MP0005388_respiratory_system_phenotype	0.59193518
86	MP0005085_abnormal_gallbladder_physiolo	0.57190321
87	MP0009643_abnormal_urine_homeostasis	0.56566491
88	MP0001486_abnormal_startle_reflex	0.56519808
89	MP0001963_abnormal_hearing_physiology	0.55149959
90	MP0001529_abnormal_vocalization	0.55009572
91	MP0002084_abnormal_developmental_patter	0.54946671
92	MP0004883_abnormal_blood_vessel	0.53941818
93	MP0001270_distended_abdomen	0.53705335
94	MP0000579_abnormal_nail_morphology	0.53344833
95	MP0005195_abnormal_posterior_eye	0.52515437
96	MP0001905_abnormal_dopamine_level	0.51825389
97	MP0003634_abnormal_glial_cell	0.51325686
98	MP0001970_abnormal_pain_threshold	0.50523840
99	MP0002229_neurodegeneration	0.50003723
100	MP0003861_abnormal_nervous_system	0.49005672

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic bronchitis (HP:0004469)	7.64992357
2	Bronchiectasis (HP:0002110)	7.26430518
3	Nasal polyposis (HP:0100582)	6.78139488
4	Abnormality of the nasal mucosa (HP:0000433)	5.64219451
5	Recurrent sinusitis (HP:0011108)	4.48863051
6	Bronchitis (HP:0012387)	4.32452502
7	Occipital encephalocele (HP:0002085)	4.06700656
8	Chronic sinusitis (HP:0011109)	3.99633575
9	Infertility (HP:0000789)	3.91857871
10	Recurrent otitis media (HP:0000403)	3.83138750
11	True hermaphroditism (HP:0010459)	3.71331926
12	Pancreatic fibrosis (HP:0100732)	3.70328815
13	Male infertility (HP:0003251)	3.43003289
14	Chronic hepatic failure (HP:0100626)	3.12095283
15	Abnormality of midbrain morphology (HP:0002418)	3.04925622
16	Molar tooth sign on MRI (HP:0002419)	3.04925622
17	Nephronophthisis (HP:0000090)	2.98974503
18	Pancreatic cysts (HP:0001737)	2.94973483
19	Cystic liver disease (HP:0006706)	2.93304446
20	Chronic otitis media (HP:0000389)	2.84774181
21	Atelectasis (HP:0100750)	2.82872595
22	Postaxial foot polydactyly (HP:0001830)	2.63146772
23	Hyperactive renin-angiotensin system (HP:0000841)	2.62924078
24	Abnormality of the renal medulla (HP:0100957)	2.31435501
25	Congenital hepatic fibrosis (HP:0002612)	2.15981566
26	Medial flaring of the eyebrow (HP:0010747)	2.13477147
27	Anencephaly (HP:0002323)	2.13040726
28	Bell-shaped thorax (HP:0001591)	2.09318461
29	Tubulointerstitial nephritis (HP:0001970)	2.09306849
30	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.07644141
31	Tubular atrophy (HP:0000092)	2.06457172
32	Recurrent bronchitis (HP:0002837)	2.03831352
33	Congenital primary aphakia (HP:0007707)	2.00578597
34	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.8365937
35	Abnormal respiratory motile cilium physiology (HP:0012261)	11.1972753
36	Abnormal ciliary motility (HP:0012262)	11.0409301
37	Abnormal respiratory epithelium morphology (HP:0012253)	10.9415979
38	Abnormal respiratory motile cilium morphology (HP:0005938)	10.9415979
39	Dynein arm defect of respiratory motile cilia (HP:0012255)	10.6949899
40	Absent/shortened dynein arms (HP:0200106)	10.6949899
41	Rhinitis (HP:0012384)	10.1751341
42	Gait imbalance (HP:0002141)	1.98513530
43	Absent frontal sinuses (HP:0002688)	1.96018666
44	Male pseudohermaphroditism (HP:0000037)	1.88942105
45	Furrowed tongue (HP:0000221)	1.84956740
46	Sclerocornea (HP:0000647)	1.84425426
47	Oculomotor apraxia (HP:0000657)	1.75031688
48	Nephrogenic diabetes insipidus (HP:0009806)	1.74571986
49	Postaxial hand polydactyly (HP:0001162)	1.73763059
50	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.73760015
51	Asplenia (HP:0001746)	1.64359262
52	Median cleft lip (HP:0000161)	1.64358634
53	Nephropathy (HP:0000112)	1.61715590
54	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.58034141
55	Renal salt wasting (HP:0000127)	1.52776392
56	Bile duct proliferation (HP:0001408)	1.50925594
57	Abnormal biliary tract physiology (HP:0012439)	1.50925594
58	Preaxial hand polydactyly (HP:0001177)	1.45577000
59	Poor coordination (HP:0002370)	1.45364922
60	Abnormality of the frontal sinuses (HP:0002687)	1.42311937
61	Decreased circulating renin level (HP:0003351)	1.40047020
62	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.38178650
63	Short nail (HP:0001799)	1.37736538
64	Vaginal atresia (HP:0000148)	1.37401637
65	Genital tract atresia (HP:0001827)	1.36577902
66	Abnormal drinking behavior (HP:0030082)	1.32029292
67	Polydipsia (HP:0001959)	1.32029292
68	Tubulointerstitial abnormality (HP:0001969)	1.30602277
69	Hyperkalemia (HP:0002153)	1.29456558
70	Hyperaldosteronism (HP:0000859)	1.28954886
71	Hypokalemic alkalosis (HP:0001949)	1.28465367
72	Abnormality of the dental root (HP:0006486)	1.26960008
73	Taurodontia (HP:0000679)	1.26960008
74	Abnormality of permanent molar morphology (HP:0011071)	1.26960008
75	Stage 5 chronic kidney disease (HP:0003774)	1.24560544
76	Abnormality of dentin (HP:0010299)	1.19235555
77	Short thorax (HP:0010306)	1.17518826
78	Cone-rod dystrophy (HP:0000548)	1.17110069
79	Abnormality of molar (HP:0011077)	1.16739158
80	Abnormality of molar morphology (HP:0011070)	1.16739158
81	Supernumerary spleens (HP:0009799)	1.15928233
82	Abnormality of the dental pulp (HP:0006479)	1.15798126
83	Abnormality of renin-angiotensin system (HP:0000847)	1.11174341
84	Abnormality of chloride homeostasis (HP:0011422)	1.10278539
85	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.09036685
86	Bifid scrotum (HP:0000048)	1.08298731
87	Narrow forehead (HP:0000341)	1.02789034
88	Glucose intolerance (HP:0000833)	1.02444021
89	Abnormality of the renal cortex (HP:0011035)	1.01693506
90	Tubulointerstitial fibrosis (HP:0005576)	1.00168031
91	Abnormality of the distal phalanges of the toes (HP:0010182)	0.99530476
92	Renal dysplasia (HP:0000110)	0.98668533
93	Aplasia/Hypoplasia of the lens (HP:0008063)	0.97604920
94	Decreased central vision (HP:0007663)	0.96915667
95	Optic nerve coloboma (HP:0000588)	0.96193433
96	Aganglionic megacolon (HP:0002251)	0.94420936
97	Prominent nasal bridge (HP:0000426)	0.93548521
98	Muscle fiber splitting (HP:0003555)	0.93359716
99	Anophthalmia (HP:0000528)	0.92541709
100	Facial cleft (HP:0002006)	0.92439046

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.47728514
2	MST4	4.33913233
3	TSSK6	3.80257373
4	PNCK	3.52827889
5	MAPKAPK3	2.38955423
6	MAPK15	12.4950932
7	STK24	1.81893618
8	MAP3K2	1.72709760
9	NME1	1.66973537
10	PTK2B	1.55783180
11	BCR	1.32460867
12	WEE1	1.31074981
13	MAP3K3	1.30446662
14	TTK	1.23018105
15	EPHB1	1.15555023
16	CSK	1.14968187
17	NEK6	1.11057233
18	EEF2K	1.07219192
19	EPHA3	0.96599072
20	MAP3K4	0.96156534
21	SMG1	0.95718692
22	STK10	0.95532618
23	ERBB2	0.94864563
24	LRRK2	0.93828250
25	MAP3K12	0.92490733
26	TRPM7	0.90554979
27	NEK9	0.84681863
28	BRSK2	0.84598016
29	TLK1	0.80486921
30	ERBB3	0.79072594
31	MAP3K7	0.78752039
32	MST1R	0.77188061
33	STK38L	0.66889760
34	MET	0.59333066
35	MAP2K7	0.56198681
36	MARK2	0.55893127
37	IRAK1	0.55014317
38	PBK	0.53359739
39	MAP2K4	0.49349189
40	PASK	0.48219383
41	CAMKK1	0.47246382
42	LATS1	0.46918179
43	PRKCI	0.43581117
44	AURKA	0.43295130
45	GRK1	0.42991126
46	TBK1	0.42800850
47	RPS6KB2	0.41948223
48	MAPKAPK5	0.39691342
49	VRK1	0.37161872
50	AKT2	0.36897570
51	MUSK	0.36874491
52	NLK	0.35342841
53	ROCK2	0.35204071
54	DYRK3	0.35124533
55	CAMK2G	0.34965169
56	DYRK1B	0.33364134
57	PRKAA2	0.33293624
58	ROCK1	0.31261885
59	ADRBK1	0.30805484
60	DYRK1A	0.30316899
61	LMTK2	0.28807865
62	PRKCD	0.28743988
63	MYLK	0.27674307
64	ABL2	0.26767756
65	PAK4	0.24767190
66	SGK1	0.24090944
67	STK38	0.23286769
68	PAK2	0.22186481
69	PRKACA	0.21445404
70	CDK3	0.21065179
71	ABL1	0.20390561
72	STK16	0.19657449
73	PRKCQ	0.19152897
74	STK39	0.18713368
75	TESK1	0.18130402
76	SGK223	0.18040295
77	SGK494	0.18040295
78	FER	0.17302982
79	RET	0.16533641
80	RIPK4	0.16043061
81	ICK	0.14692986
82	BMPR2	0.14041399
83	CAMKK2	0.13744865
84	MAP2K2	0.13649580
85	CAMK2A	0.13526285
86	CDK6	0.12624394
87	RPS6KA2	0.12525245
88	BLK	0.12079680
89	PRKCA	0.11774684
90	SGK2	0.11314977
91	STK3	0.11224891
92	CHUK	0.11216240
93	PLK1	0.11118597
94	MAPK10	0.10839307
95	PTK2	0.10755121
96	PTK6	0.10681219
97	INSRR	0.10293673
98	NTRK2	0.10142691
99	PRKG1	0.09988137
100	PIM2	0.09621239

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	5.23531490
2	Phenylalanine metabolism_Homo sapiens_hsa00360	4.57086484
3	Histidine metabolism_Homo sapiens_hsa00340	4.30020800
4	Chemical carcinogenesis_Homo sapiens_hsa05204	4.11857070
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	4.06440610
6	Huntingtons disease_Homo sapiens_hsa05016	3.44513925
7	Tyrosine metabolism_Homo sapiens_hsa00350	3.40920730
8	beta-Alanine metabolism_Homo sapiens_hsa00410	2.72705900
9	Glutathione metabolism_Homo sapiens_hsa00480	2.65688763
10	Linoleic acid metabolism_Homo sapiens_hsa00591	1.98163629
11	Retinol metabolism_Homo sapiens_hsa00830	1.87282055
12	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.77715845
13	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.73148215
14	Sphingolipid metabolism_Homo sapiens_hsa00600	1.73102836
15	Caffeine metabolism_Homo sapiens_hsa00232	1.69533012
16	ABC transporters_Homo sapiens_hsa02010	1.69047286
17	Tight junction_Homo sapiens_hsa04530	1.57597828
18	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.57412018
19	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.53210229
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.43090351
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.41238522
22	Basal cell carcinoma_Homo sapiens_hsa05217	1.40250043
23	Circadian rhythm_Homo sapiens_hsa04710	1.36395805
24	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.30584982
25	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.30057858
26	Notch signaling pathway_Homo sapiens_hsa04330	1.20645740
27	Fatty acid degradation_Homo sapiens_hsa00071	1.19047182
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.18016638
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.10407993
30	Salivary secretion_Homo sapiens_hsa04970	1.08197984
31	Peroxisome_Homo sapiens_hsa04146	1.07858685
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.05793498
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.95918835
34	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.90530799
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.85368367
36	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.83915617
37	Olfactory transduction_Homo sapiens_hsa04740	0.78885668
38	PPAR signaling pathway_Homo sapiens_hsa03320	0.75224350
39	Choline metabolism in cancer_Homo sapiens_hsa05231	0.72466740
40	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.72422551
41	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.69872093
42	Adherens junction_Homo sapiens_hsa04520	0.66211350
43	Cardiac muscle contraction_Homo sapiens_hsa04260	0.65197099
44	Taste transduction_Homo sapiens_hsa04742	0.64792321
45	Cocaine addiction_Homo sapiens_hsa05030	0.63402800
46	Hippo signaling pathway_Homo sapiens_hsa04390	0.62338211
47	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.57995823
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57463609
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.56275143
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.54227951
51	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53609950
52	Folate biosynthesis_Homo sapiens_hsa00790	0.52722574
53	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.52302053
54	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.50810511
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49888892
56	Nicotine addiction_Homo sapiens_hsa05033	0.48541242
57	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.47346743
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47281341
59	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.46042104
60	cAMP signaling pathway_Homo sapiens_hsa04024	0.45673945
61	Antigen processing and presentation_Homo sapiens_hsa04612	0.43626208
62	Phototransduction_Homo sapiens_hsa04744	0.43183754
63	Axon guidance_Homo sapiens_hsa04360	0.43091160
64	Lysosome_Homo sapiens_hsa04142	0.41852532
65	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.40954564
66	Butanoate metabolism_Homo sapiens_hsa00650	0.40897715
67	Complement and coagulation cascades_Homo sapiens_hsa04610	0.40097111
68	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.38890608
69	Amoebiasis_Homo sapiens_hsa05146	0.37788647
70	Hepatitis C_Homo sapiens_hsa05160	0.36989557
71	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.34683562
72	Prion diseases_Homo sapiens_hsa05020	0.34647358
73	Wnt signaling pathway_Homo sapiens_hsa04310	0.34159102
74	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.34070107
75	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.33807326
76	Bile secretion_Homo sapiens_hsa04976	0.32769051
77	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.31782038
78	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.31563516
79	Metabolic pathways_Homo sapiens_hsa01100	0.31032740
80	Melanogenesis_Homo sapiens_hsa04916	0.30734436
81	Amphetamine addiction_Homo sapiens_hsa05031	0.30571112
82	ECM-receptor interaction_Homo sapiens_hsa04512	0.29294069
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.28021288
84	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.27998105
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.26597658
86	Pancreatic secretion_Homo sapiens_hsa04972	0.25382440
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.24443184
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.23449879
89	Oxidative phosphorylation_Homo sapiens_hsa00190	0.21605227
90	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.20155558
91	Serotonergic synapse_Homo sapiens_hsa04726	0.19946760
92	Alzheimers disease_Homo sapiens_hsa05010	0.17744071
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.17722597
94	Legionellosis_Homo sapiens_hsa05134	0.16885769
95	Phagosome_Homo sapiens_hsa04145	0.15882219
96	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.13328377
97	Estrogen signaling pathway_Homo sapiens_hsa04915	0.13254076
98	Alcoholism_Homo sapiens_hsa05034	0.12447839
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.10723818
100	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.10528846

C7ORF57

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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