C7ORF77

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1female mating behavior (GO:0060180)9.41405082
2skeletal muscle tissue regeneration (GO:0043403)8.68795079
3phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)8.46637292
4negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)7.37426010
5mature B cell differentiation (GO:0002335)7.31081233
6positive regulation of inositol phosphate biosynthetic process (GO:0060732)7.20842258
7synaptic transmission, dopaminergic (GO:0001963)6.67612935
8protein targeting to lysosome (GO:0006622)6.65658575
9establishment of protein localization to vacuole (GO:0072666)6.65658575
10protein targeting to vacuole (GO:0006623)6.65658575
11cellular glucuronidation (GO:0052695)6.54258022
12adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.36821546
13lipoxygenase pathway (GO:0019372)6.28405344
14glucuronate metabolic process (GO:0019585)6.06860165
15uronic acid metabolic process (GO:0006063)6.06860165
16detection of light stimulus involved in sensory perception (GO:0050962)6.00793320
17detection of light stimulus involved in visual perception (GO:0050908)6.00793320
18polarized epithelial cell differentiation (GO:0030859)5.93377845
19coenzyme catabolic process (GO:0009109)5.85305777
20embryonic heart tube development (GO:0035050)5.84447860
21regulation of inositol phosphate biosynthetic process (GO:0010919)5.75770601
22pantothenate metabolic process (GO:0015939)5.63972469
23morphogenesis of an endothelium (GO:0003159)5.59624619
24endothelial tube morphogenesis (GO:0061154)5.59624619
25long term synaptic depression (GO:0060292)5.40785946
26glycosphingolipid biosynthetic process (GO:0006688)5.19652065
27negative regulation of oxidoreductase activity (GO:0051354)5.19278417
28positive regulation of cAMP-mediated signaling (GO:0043950)5.17583288
29protein localization to lysosome (GO:0061462)4.97552087
30protein localization to vacuole (GO:0072665)4.97552087
31regulation of sensory perception (GO:0051931)4.96676807
32regulation of sensory perception of pain (GO:0051930)4.96676807
33lymphangiogenesis (GO:0001946)4.87231142
34regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.83464580
35regulation of MHC class II biosynthetic process (GO:0045346)4.82121938
36collecting duct development (GO:0072044)4.55913934
37positive regulation of chemokine secretion (GO:0090197)4.34088780
38regulation of macrophage chemotaxis (GO:0010758)4.33272119
39pericardium development (GO:0060039)4.25432258
40neuronal action potential (GO:0019228)4.20236473
41apical protein localization (GO:0045176)4.19938981
42regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.07504749
43transmission of nerve impulse (GO:0019226)4.05695412
44venous blood vessel morphogenesis (GO:0048845)3.98645686
45glycosylceramide metabolic process (GO:0006677)3.95471249
46positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.91810831
47receptor guanylyl cyclase signaling pathway (GO:0007168)3.84122127
48positive regulation of macrophage differentiation (GO:0045651)3.83898627
49basic amino acid transport (GO:0015802)3.79673847
50primary amino compound metabolic process (GO:1901160)3.79090092
51multicellular organismal reproductive behavior (GO:0033057)3.75076492
52regulation of chemokine secretion (GO:0090196)3.74576162
53nonmotile primary cilium assembly (GO:0035058)3.69759408
54endothelial cell development (GO:0001885)3.69375714
55regulation of germinal center formation (GO:0002634)3.59182714
56leukocyte tethering or rolling (GO:0050901)3.51610052
57GTP biosynthetic process (GO:0006183)3.39567033
58positive regulation of calcium-mediated signaling (GO:0050850)3.37112067
59activation of adenylate cyclase activity (GO:0007190)3.31863899
60negative regulation of dendrite development (GO:2000171)3.28238452
61B cell activation involved in immune response (GO:0002312)3.23866711
62positive regulation of phosphatase activity (GO:0010922)3.23207800
63tissue regeneration (GO:0042246)3.19836840
64purine ribonucleotide transport (GO:0015868)3.17248996
65fat-soluble vitamin biosynthetic process (GO:0042362)3.16167286
66cofactor catabolic process (GO:0051187)3.12491280
67serotonin metabolic process (GO:0042428)3.05995227
68regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.04093049
69endocrine process (GO:0050886)3.04093049
70regulation of systemic arterial blood pressure by hormone (GO:0001990)3.04093049
71regulation of transcription from RNA polymerase I promoter (GO:0006356)3.01577405
72positive regulation of interleukin-8 secretion (GO:2000484)2.97794257
73UTP biosynthetic process (GO:0006228)2.97458737
74negative regulation of monooxygenase activity (GO:0032769)2.96716899
75positive regulation of adenylate cyclase activity (GO:0045762)2.93649512
76response to amphetamine (GO:0001975)2.92704487
77DNA deamination (GO:0045006)2.92564670
78adenine nucleotide transport (GO:0051503)2.90655828
79protein localization to cilium (GO:0061512)2.89078339
80positive regulation of alcohol biosynthetic process (GO:1902932)2.87331212
81regulation of megakaryocyte differentiation (GO:0045652)2.86746357
82membrane depolarization during action potential (GO:0086010)2.86344808
83detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.84309125
84cellular response to monoamine stimulus (GO:0071868)2.82841789
85cellular response to catecholamine stimulus (GO:0071870)2.82841789
86indolalkylamine metabolic process (GO:0006586)2.81843917
87protein polyglutamylation (GO:0018095)2.81669508
88endothelial cell differentiation (GO:0045446)2.81506748
89phosphatidylethanolamine biosynthetic process (GO:0006646)2.77045316
90positive regulation of antigen processing and presentation (GO:0002579)2.75583066
91sensory perception of smell (GO:0007608)2.75351817
92regulation of calcium-mediated signaling (GO:0050848)2.72933049
93leukotriene biosynthetic process (GO:0019370)2.72137668
94fat-soluble vitamin metabolic process (GO:0006775)2.71041543
95platelet degranulation (GO:0002576)2.67271755
96regulation of mesoderm development (GO:2000380)2.66827339
97fat-soluble vitamin catabolic process (GO:0042363)11.5947714
98vitamin catabolic process (GO:0009111)11.5947714
99regulation of female receptivity (GO:0045924)10.6752360
100mature B cell differentiation involved in immune response (GO:0002313)10.0746585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR4A2_19515692_ChIP-ChIP_MN9D_Mouse5.24529660
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.32352831
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.06053975
4ESR1_20079471_ChIP-ChIP_T-47D_Human3.02584936
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.97359405
6ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.81561237
7GBX2_23144817_ChIP-Seq_PC3_Human2.78368255
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.68511127
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.68511127
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.68511127
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.59132760
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50431407
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.48528120
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44976006
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23159639
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04453958
17RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.00512860
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96904495
19ARNT_22903824_ChIP-Seq_MCF-7_Human1.94444978
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92634307
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91806331
22DROSHA_22980978_ChIP-Seq_HELA_Human1.91666870
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84256572
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80472398
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79424681
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78923913
27SMAD3_21741376_ChIP-Seq_EPCs_Human1.75603701
28SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.73892426
29AUTS2_25519132_ChIP-Seq_293T-REX_Human1.70401976
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70107043
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70107043
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68445018
33EWS_26573619_Chip-Seq_HEK293_Human1.67879743
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.67558634
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.66826924
36BCAT_22108803_ChIP-Seq_LS180_Human1.62288980
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.58741094
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57405105
39NCOR_22424771_ChIP-Seq_293T_Human1.56651898
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54874525
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54502547
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50328849
43STAT3_23295773_ChIP-Seq_U87_Human1.37635570
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37415116
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36851643
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.35635110
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35373935
48EZH2_22144423_ChIP-Seq_EOC_Human1.35123957
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31975096
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30285406
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29028859
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28477467
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28035529
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26579913
55SOX2_21211035_ChIP-Seq_LN229_Human1.25448036
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24627384
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24627384
58AHR_22903824_ChIP-Seq_MCF-7_Human1.23795720
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23526691
60P53_21459846_ChIP-Seq_SAOS-2_Human1.22809220
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.22643520
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.22432536
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19694146
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16945446
65REST_21632747_ChIP-Seq_MESCs_Mouse1.15717814
66OCT4_19829295_ChIP-Seq_ESCs_Human1.15341389
67SMAD4_21799915_ChIP-Seq_A2780_Human1.15106511
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.14037649
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.12777469
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12720097
71RAD21_21589869_ChIP-Seq_MESCs_Mouse1.09815761
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.09175018
73TCF4_18268006_ChIP-ChIP_LS174T_Human1.08928512
74CBP_20019798_ChIP-Seq_JUKART_Human1.08396743
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08396743
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08106368
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06607371
78TCF4_23295773_ChIP-Seq_U87_Human1.04852363
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04203511
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03805296
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02421863
82TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02157803
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01694991
84OCT1_27270436_Chip-Seq_PROSTATE_Human1.01643968
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97568812
86NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96980682
87RAC3_21632823_ChIP-Seq_H3396_Human0.95718888
88CDX2_20551321_ChIP-Seq_CACO-2_Human0.95574748
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95355932
90SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95281615
91FUS_26573619_Chip-Seq_HEK293_Human0.95068599
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.94293638
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92838859
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92563317
95LXR_22158963_ChIP-Seq_LIVER_Mouse0.92095827
96RING1B_27294783_Chip-Seq_NPCs_Mouse0.89753499
97CTCF_20526341_ChIP-Seq_ESCs_Human0.89443356
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89225250
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89202920
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.88762741

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology9.70611881
2MP0002736_abnormal_nociception_after6.22876080
3MP0005409_darkened_coat_color5.79584529
4MP0005360_urolithiasis5.41644801
5MP0001968_abnormal_touch/_nociception4.62797841
6MP0003172_abnormal_lysosome_physiology4.47082681
7MP0009840_abnormal_foam_cell4.31408490
8MP0009697_abnormal_copulation3.47565435
9MP0002909_abnormal_adrenal_gland3.45382440
10MP0000678_abnormal_parathyroid_gland3.29399795
11MP0006276_abnormal_autonomic_nervous3.14907081
12MP0002734_abnormal_mechanical_nocicepti2.52037837
13MP0005083_abnormal_biliary_tract2.49917019
14MP0003724_increased_susceptibility_to2.04622433
15MP0009053_abnormal_anal_canal1.97056834
16MP0002928_abnormal_bile_duct1.72723832
17MP0002277_abnormal_respiratory_mucosa1.67490084
18MP0005646_abnormal_pituitary_gland1.49524172
19MP0003646_muscle_fatigue1.46880234
20MP0001879_abnormal_lymphatic_vessel1.33982172
21MP0001873_stomach_inflammation1.30149482
22MP0004742_abnormal_vestibular_system1.24223902
23MP0002148_abnormal_hypersensitivity_rea1.19938868
24MP0008789_abnormal_olfactory_epithelium1.19034720
25MP0001970_abnormal_pain_threshold1.18452275
26MP0001984_abnormal_olfaction1.17870267
27MP0003136_yellow_coat_color1.17292567
28MP0000537_abnormal_urethra_morphology1.11701557
29MP0000534_abnormal_ureter_morphology1.06161521
30MP0000516_abnormal_urinary_system1.00843582
31MP0005367_renal/urinary_system_phenotyp1.00843582
32MP0002933_joint_inflammation1.00787030
33MP0003119_abnormal_digestive_system0.99298269
34MP0003718_maternal_effect0.99058199
35MP0003868_abnormal_feces_composition0.97594243
36MP0000049_abnormal_middle_ear0.90252021
37MP0002127_abnormal_cardiovascular_syste0.90181289
38MP0003195_calcinosis0.89006207
39MP0001502_abnormal_circadian_rhythm0.88328566
40MP0002098_abnormal_vibrissa_morphology0.88279037
41MP0004859_abnormal_synaptic_plasticity0.85505052
42MP0005499_abnormal_olfactory_system0.85498056
43MP0005394_taste/olfaction_phenotype0.85498056
44MP0004381_abnormal_hair_follicle0.82612991
45MP0002249_abnormal_larynx_morphology0.81006514
46MP0002735_abnormal_chemical_nociception0.80837173
47MP0003950_abnormal_plasma_membrane0.77967219
48MP0000538_abnormal_urinary_bladder0.77173889
49MP0003879_abnormal_hair_cell0.76987207
50MP0002132_abnormal_respiratory_system0.75249650
51MP0000613_abnormal_salivary_gland0.74150608
52MP0006292_abnormal_olfactory_placode0.73517067
53MP0009250_abnormal_appendicular_skeleto0.73226372
54MP0002282_abnormal_trachea_morphology0.72890609
55MP0004085_abnormal_heartbeat0.69404857
56MP0004130_abnormal_muscle_cell0.68853928
57MP0003938_abnormal_ear_development0.67591180
58MP0010771_integument_phenotype0.65258535
59MP0000631_abnormal_neuroendocrine_gland0.63809166
60MP0002272_abnormal_nervous_system0.62939907
61MP0002138_abnormal_hepatobiliary_system0.60955713
62MP0009278_abnormal_bone_marrow0.59929223
63MP0000230_abnormal_systemic_arterial0.58262653
64MP0000467_abnormal_esophagus_morphology0.57808769
65MP0001963_abnormal_hearing_physiology0.55539502
66MP0006072_abnormal_retinal_apoptosis0.55530460
67MP0003252_abnormal_bile_duct0.54555656
68MP0005332_abnormal_amino_acid0.54444209
69MP0002896_abnormal_bone_mineralization0.53908030
70MP0000026_abnormal_inner_ear0.53539765
71MP0002837_dystrophic_cardiac_calcinosis0.52354409
72MP0000681_abnormal_thyroid_gland0.51200443
73MP0002572_abnormal_emotion/affect_behav0.50248849
74MP0000249_abnormal_blood_vessel0.49923125
75MP0003075_altered_response_to0.49515523
76MP0001666_abnormal_nutrient_absorption0.46767461
77MP0000377_abnormal_hair_follicle0.44301703
78MP0000470_abnormal_stomach_morphology0.43717561
79MP0002733_abnormal_thermal_nociception0.43630411
80MP0008872_abnormal_physiological_respon0.42697628
81MP0002405_respiratory_system_inflammati0.41819477
82MP0001663_abnormal_digestive_system0.41030252
83MP0005253_abnormal_eye_physiology0.39831919
84MP0002160_abnormal_reproductive_system0.38920247
85MP0009764_decreased_sensitivity_to0.38387755
86MP0001270_distended_abdomen0.38119421
87MP0005390_skeleton_phenotype0.37913300
88MP0001533_abnormal_skeleton_physiology0.37302380
89MP0000465_gastrointestinal_hemorrhage0.37260637
90MP0003011_delayed_dark_adaptation0.36916300
91MP0010386_abnormal_urinary_bladder0.36521626
92MP0005671_abnormal_response_to0.35771004
93MP0005551_abnormal_eye_electrophysiolog0.32929686
94MP0004134_abnormal_chest_morphology0.32663103
95MP0001440_abnormal_grooming_behavior0.31531435
96MP0003303_peritoneal_inflammation0.30904615
97MP0009333_abnormal_splenocyte_physiolog0.30789978
98MP0005381_digestive/alimentary_phenotyp0.30059388
99MP0002075_abnormal_coat/hair_pigmentati0.28567239
100MP0002419_abnormal_innate_immunity0.28000762

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)7.80635180
2Absent/shortened dynein arms (HP:0200106)7.80635180
3Abnormality of cochlea (HP:0000375)6.85308585
4Dysautonomia (HP:0002459)6.61534240
5Failure to thrive in infancy (HP:0001531)6.50141754
6Poor head control (HP:0002421)6.34102598
7Morphological abnormality of the inner ear (HP:0011390)5.45333718
8Keratoconjunctivitis sicca (HP:0001097)5.44709000
9Follicular hyperkeratosis (HP:0007502)5.42441861
10Decreased central vision (HP:0007663)5.38236551
11Keratoconjunctivitis (HP:0001096)5.04450740
12Tinnitus (HP:0000360)4.85397364
13Absent phalangeal crease (HP:0006109)4.72784920
14Bony spicule pigmentary retinopathy (HP:0007737)4.58989945
15Lymphangioma (HP:0100764)4.53980294
16Abolished electroretinogram (ERG) (HP:0000550)4.53944767
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.47434581
18Constricted visual fields (HP:0001133)4.37690789
19Abnormal respiratory motile cilium morphology (HP:0005938)4.05937703
20Abnormal respiratory epithelium morphology (HP:0012253)4.05937703
21Cone-rod dystrophy (HP:0000548)3.96132255
22Abnormal finger flexion creases (HP:0006143)3.90428353
23Abnormal autonomic nervous system physiology (HP:0012332)3.88140036
24Abnormality of the costochondral junction (HP:0000919)3.80072882
25Abnormal ciliary motility (HP:0012262)3.66531367
26Nonimmune hydrops fetalis (HP:0001790)3.64194859
27Impaired pain sensation (HP:0007328)3.64085706
28Abnormality of pain sensation (HP:0010832)3.64085706
29Ulnar deviation of the wrist (HP:0003049)3.59933270
30Morphological abnormality of the middle ear (HP:0008609)3.58568226
31Generalized aminoaciduria (HP:0002909)3.55719749
32Attenuation of retinal blood vessels (HP:0007843)3.55335651
33Round ear (HP:0100830)3.48003566
34Abnormality of the proximal phalanges of the hand (HP:0009834)3.42713438
35Distal arthrogryposis (HP:0005684)3.23142697
36Recurrent sinusitis (HP:0011108)3.09518566
37Calcaneovalgus deformity (HP:0001848)3.07587709
38Absent eyebrow (HP:0002223)2.99080559
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.92716127
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.92448202
41Keratoconus (HP:0000563)2.90800420
42Increased corneal curvature (HP:0100692)2.90800420
43Absent eyelashes (HP:0000561)2.82373039
44Deformed tarsal bones (HP:0008119)2.75188186
45Abnormal respiratory motile cilium physiology (HP:0012261)2.68451668
46Thin bony cortex (HP:0002753)2.58354695
47Mesangial abnormality (HP:0001966)2.52462740
48Delayed epiphyseal ossification (HP:0002663)2.49733052
49Tibial bowing (HP:0002982)2.48011013
50Keratitis (HP:0000491)2.47915274
51Pustule (HP:0200039)2.44364652
52Abnormality of the nasal septum (HP:0000419)2.43291734
53Progressive microcephaly (HP:0000253)2.43229530
54Chest pain (HP:0100749)2.41407179
55Abnormality of the middle phalanges of the toes (HP:0010183)2.37552618
56Epidermoid cyst (HP:0200040)2.37266197
57Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.34179558
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.28783986
59Hypotrichosis (HP:0001006)2.26493660
60Abnormality of the peritoneum (HP:0002585)2.22215368
61Enlarged epiphyses (HP:0010580)2.19006189
62Abnormality of the phalanges of the 5th finger (HP:0004213)2.16035278
63Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.14180441
64Short 1st metacarpal (HP:0010034)2.14180441
65Poor suck (HP:0002033)2.13505169
66B lymphocytopenia (HP:0010976)2.13331400
67Epiphyseal dysplasia (HP:0002656)2.10664400
68Stenosis of the external auditory canal (HP:0000402)2.06285822
69Symptomatic seizures (HP:0011145)2.00595973
70Cupped ribs (HP:0000887)1.99598700
71Autoimmune thrombocytopenia (HP:0001973)1.99573362
72Arterial thrombosis (HP:0004420)1.96012370
73Short tibia (HP:0005736)1.95720636
74Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.94044280
75Severe Myopia (HP:0011003)1.93928238
76Abnormality of the 1st metacarpal (HP:0010009)1.92199887
77Abnormality of the renal collecting system (HP:0004742)1.91243671
78Lip pit (HP:0100267)1.90705540
79Thyroiditis (HP:0100646)1.90633500
80Long nose (HP:0003189)1.90115033
81Vertigo (HP:0002321)1.88487204
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.84362863
83Widely patent fontanelles and sutures (HP:0004492)1.83637252
84Short hallux (HP:0010109)1.83444432
85Amaurosis fugax (HP:0100576)1.82929378
86Photophobia (HP:0000613)1.80899500
87Alopecia of scalp (HP:0002293)1.78377157
88Symphalangism affecting the phalanges of the hand (HP:0009773)1.77694129
89Humeroradial synostosis (HP:0003041)1.77603179
90Synostosis involving the elbow (HP:0003938)1.77603179
91Abnormality of B cell number (HP:0010975)1.75617313
92Hamartoma of the eye (HP:0010568)1.74708265
93Autoimmune hemolytic anemia (HP:0001890)1.71029909
94Absent hair (HP:0002298)1.70666572
95Synostosis of carpal bones (HP:0005048)1.70454497
96Opisthotonus (HP:0002179)1.69896895
97Ulnar deviation of finger (HP:0009465)1.68076182
98Aplasia/Hypoplasia of the hallux (HP:0008362)1.67925680
99Neoplasm of the adrenal cortex (HP:0100641)1.66678753
100Congenital primary aphakia (HP:0007707)1.62740875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K26.58375713
2CDK43.79822874
3STK383.74680891
4NUAK13.73568281
5GRK13.29191920
6FRK3.27142447
7ZAK2.98293512
8CDK122.87685296
9MAP2K12.82546321
10BMPR1B2.63051156
11TAOK32.32301068
12CSNK1G32.16568584
13CSNK1A1L1.94626392
14CHEK21.86837239
15PIK3CA1.86505345
16PTK21.79640363
17CSNK1G11.67983458
18CSNK1G21.61318994
19CAMKK21.55890551
20PLK21.55545541
21TAF11.53234409
22CDK61.37830384
23VRK21.34106664
24DAPK11.32719129
25CAMK1D1.29079239
26MAPK41.22368802
27SMG11.20371923
28ERN11.16539180
29GRK51.15154336
30TXK1.05933933
31PRKCZ1.05282202
32PAK41.03656364
33MAPK150.98108164
34PTK2B0.97786641
35CAMK2B0.96274072
36IRAK40.94377559
37ERBB20.91844908
38INSRR0.91790795
39ADRBK20.86568679
40ABL20.86567778
41MYLK0.82323179
42BLK0.81433166
43HIPK20.80963836
44ZAP700.79651233
45OBSCN0.77670235
46EPHB20.72658114
47KIT0.69768044
48MAP4K20.66622339
49MAPKAPK20.65326516
50MAPKAPK50.65278750
51SYK0.64648096
52MAP2K60.60756949
53PRKD20.60057614
54MUSK0.57491558
55PAK60.57106244
56CSNK1A10.55147602
57MAPK10.54039920
58MTOR0.53748276
59CAMK10.53709282
60KDR0.52544821
61TGFBR10.52274791
62CAMK2A0.49013654
63PRKCE0.47279798
64PRKCA0.46352676
65VRK10.46224359
66IKBKB0.42890781
67GRK70.42776759
68PRKACG0.42571369
69CAMK1G0.41961956
70FLT30.40699750
71GSK3A0.40357702
72AURKA0.39895261
73MAPK30.37580323
74WNK30.36675893
75MAPK80.35004247
76GRK60.34716026
77PLK30.34512378
78PRKACA0.33897981
79LCK0.33827156
80BCR0.33718911
81CSNK1D0.33696371
82PRKCB0.32904404
83TIE10.32740646
84ADRBK10.32594000
85PRKD10.32519529
86PRKCH0.31899695
87CHEK10.30932005
88CDK150.30254931
89PRKCQ0.29571394
90LYN0.27962611
91CDK80.27893265
92MATK0.27580697
93PKN10.27385995
94PRKCG0.27342747
95CDK11A0.26931702
96CDK180.26903426
97ABL10.26142499
98MAPK130.25945208
99FYN0.25901654
100PRKCI0.25183388

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000535.26683608
2Sulfur metabolism_Homo sapiens_hsa009204.19777405
3Pentose and glucuronate interconversions_Homo sapiens_hsa000404.13019803
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.24485029
5Steroid hormone biosynthesis_Homo sapiens_hsa001403.13889738
6Starch and sucrose metabolism_Homo sapiens_hsa005003.12500119
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.03761701
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.99935866
9Retinol metabolism_Homo sapiens_hsa008302.97991414
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.96659411
11Drug metabolism - other enzymes_Homo sapiens_hsa009832.92632897
12Olfactory transduction_Homo sapiens_hsa047402.92006211
13Histidine metabolism_Homo sapiens_hsa003402.75948203
14Chemical carcinogenesis_Homo sapiens_hsa052042.71646377
15Sulfur relay system_Homo sapiens_hsa041222.29711432
16Intestinal immune network for IgA production_Homo sapiens_hsa046722.18943297
17Phototransduction_Homo sapiens_hsa047441.83090416
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.80872781
19Arachidonic acid metabolism_Homo sapiens_hsa005901.63933251
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63665670
21Ether lipid metabolism_Homo sapiens_hsa005651.63573166
22beta-Alanine metabolism_Homo sapiens_hsa004101.62133151
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.43710496
24Arginine and proline metabolism_Homo sapiens_hsa003301.36893127
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32236207
26Homologous recombination_Homo sapiens_hsa034401.30043815
27Lysine degradation_Homo sapiens_hsa003101.28713157
28Protein digestion and absorption_Homo sapiens_hsa049741.24982172
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14393727
30Tryptophan metabolism_Homo sapiens_hsa003801.09102160
31ABC transporters_Homo sapiens_hsa020101.04473410
32Staphylococcus aureus infection_Homo sapiens_hsa051500.89122739
33Glycerolipid metabolism_Homo sapiens_hsa005610.88278265
34Glycerophospholipid metabolism_Homo sapiens_hsa005640.82868069
35Renin secretion_Homo sapiens_hsa049240.82844690
36Asthma_Homo sapiens_hsa053100.80526629
37Legionellosis_Homo sapiens_hsa051340.80377807
38Steroid biosynthesis_Homo sapiens_hsa001000.80001574
39Nicotine addiction_Homo sapiens_hsa050330.75150738
40Calcium signaling pathway_Homo sapiens_hsa040200.72369897
41Complement and coagulation cascades_Homo sapiens_hsa046100.69071881
42Insulin secretion_Homo sapiens_hsa049110.68043028
43Renin-angiotensin system_Homo sapiens_hsa046140.67204587
44Taste transduction_Homo sapiens_hsa047420.64961174
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64865473
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64703031
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60354009
48Lysosome_Homo sapiens_hsa041420.58924532
49Sphingolipid metabolism_Homo sapiens_hsa006000.57967915
50Circadian entrainment_Homo sapiens_hsa047130.57280570
51ECM-receptor interaction_Homo sapiens_hsa045120.57156758
52cAMP signaling pathway_Homo sapiens_hsa040240.55238116
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53160654
54DNA replication_Homo sapiens_hsa030300.50062404
55Gastric acid secretion_Homo sapiens_hsa049710.49558732
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49013920
57Primary immunodeficiency_Homo sapiens_hsa053400.48159525
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.47391033
59Mismatch repair_Homo sapiens_hsa034300.44788445
60Glutathione metabolism_Homo sapiens_hsa004800.42334518
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.40815807
62Nitrogen metabolism_Homo sapiens_hsa009100.39546076
63Peroxisome_Homo sapiens_hsa041460.39205019
64Dopaminergic synapse_Homo sapiens_hsa047280.38007448
65PPAR signaling pathway_Homo sapiens_hsa033200.34825045
66Autoimmune thyroid disease_Homo sapiens_hsa053200.34009873
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.33233721
68Metabolic pathways_Homo sapiens_hsa011000.32955028
69Graft-versus-host disease_Homo sapiens_hsa053320.32181758
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31692531
71Allograft rejection_Homo sapiens_hsa053300.31413534
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.28801465
73Pertussis_Homo sapiens_hsa051330.28280722
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.25778026
75Collecting duct acid secretion_Homo sapiens_hsa049660.25199182
76Hematopoietic cell lineage_Homo sapiens_hsa046400.25045796
77Rheumatoid arthritis_Homo sapiens_hsa053230.22096740
78Caffeine metabolism_Homo sapiens_hsa002320.21871490
79Galactose metabolism_Homo sapiens_hsa000520.21064860
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.20530623
81Cocaine addiction_Homo sapiens_hsa050300.20457195
82Type II diabetes mellitus_Homo sapiens_hsa049300.19271347
83Systemic lupus erythematosus_Homo sapiens_hsa053220.18532171
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17381243
85Vitamin B6 metabolism_Homo sapiens_hsa007500.16513759
86Type I diabetes mellitus_Homo sapiens_hsa049400.14782185
87Basal cell carcinoma_Homo sapiens_hsa052170.14561000
88Serotonergic synapse_Homo sapiens_hsa047260.13868102
89Leishmaniasis_Homo sapiens_hsa051400.12728169
90Synaptic vesicle cycle_Homo sapiens_hsa047210.11830590
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.09569571
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.08599869
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.05620679
94Linoleic acid metabolism_Homo sapiens_hsa005910.04876741
95Amphetamine addiction_Homo sapiens_hsa050310.03731663
96Vitamin digestion and absorption_Homo sapiens_hsa049770.03587979
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.02920359
98Ovarian steroidogenesis_Homo sapiens_hsa049130.02064555
99Base excision repair_Homo sapiens_hsa034100.01608190
100Salivary secretion_Homo sapiens_hsa049700.01518261

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