C8G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.66209106
2L-phenylalanine catabolic process (GO:0006559)7.66209106
3L-phenylalanine metabolic process (GO:0006558)7.33372824
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.33372824
5epoxygenase P450 pathway (GO:0019373)7.01526049
6aromatic amino acid family catabolic process (GO:0009074)6.90435582
7exogenous drug catabolic process (GO:0042738)6.60413147
8omega-hydroxylase P450 pathway (GO:0097267)6.53708085
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.42588656
10tryptophan catabolic process (GO:0006569)6.23732968
11indole-containing compound catabolic process (GO:0042436)6.23732968
12indolalkylamine catabolic process (GO:0046218)6.23732968
13kynurenine metabolic process (GO:0070189)6.09133691
14bile acid biosynthetic process (GO:0006699)6.01971057
15regulation of plasminogen activation (GO:0010755)5.99677052
16tryptophan metabolic process (GO:0006568)5.86919773
17glyoxylate metabolic process (GO:0046487)5.81507201
18urea cycle (GO:0000050)5.68277631
19urea metabolic process (GO:0019627)5.68277631
20high-density lipoprotein particle remodeling (GO:0034375)5.66590730
21alpha-linolenic acid metabolic process (GO:0036109)5.62490747
22negative regulation of fibrinolysis (GO:0051918)5.60633887
23drug metabolic process (GO:0017144)5.46457692
24regulation of fibrinolysis (GO:0051917)5.40724991
25peptidyl-glutamic acid carboxylation (GO:0017187)5.40402398
26protein carboxylation (GO:0018214)5.40402398
27sulfur amino acid catabolic process (GO:0000098)5.38683932
28cysteine metabolic process (GO:0006534)5.36747114
29oxidative demethylation (GO:0070989)5.27221594
30nitrogen cycle metabolic process (GO:0071941)5.22967955
31serine family amino acid catabolic process (GO:0009071)5.16282794
32bile acid metabolic process (GO:0008206)5.13514147
33* regulation of protein activation cascade (GO:2000257)5.08100168
34acute-phase response (GO:0006953)5.04028486
35aromatic amino acid family metabolic process (GO:0009072)5.02086087
36regulation of cholesterol esterification (GO:0010872)4.94608617
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.91702759
38reverse cholesterol transport (GO:0043691)4.90831109
39regulation of triglyceride catabolic process (GO:0010896)4.90071127
40phenylpropanoid metabolic process (GO:0009698)4.87599613
41* complement activation, alternative pathway (GO:0006957)4.86915816
42tyrosine metabolic process (GO:0006570)4.84806140
43positive regulation of fatty acid biosynthetic process (GO:0045723)4.81471335
44plasma lipoprotein particle remodeling (GO:0034369)4.81418848
45protein-lipid complex remodeling (GO:0034368)4.81418848
46macromolecular complex remodeling (GO:0034367)4.81418848
47negative regulation of blood coagulation (GO:0030195)4.79537970
48negative regulation of hemostasis (GO:1900047)4.79537970
49homocysteine metabolic process (GO:0050667)4.72766396
50* regulation of complement activation (GO:0030449)4.69125641
51alpha-amino acid catabolic process (GO:1901606)4.68526810
52negative regulation of sterol transport (GO:0032372)4.67729801
53negative regulation of cholesterol transport (GO:0032375)4.67729801
54acylglycerol homeostasis (GO:0055090)4.67006421
55triglyceride homeostasis (GO:0070328)4.67006421
56phospholipid efflux (GO:0033700)4.65535198
57lysine metabolic process (GO:0006553)4.62192806
58lysine catabolic process (GO:0006554)4.62192806
59amino-acid betaine metabolic process (GO:0006577)4.58929954
60cellular ketone body metabolic process (GO:0046950)4.50638976
61coenzyme catabolic process (GO:0009109)4.48464699
62glycine metabolic process (GO:0006544)4.47530059
63negative regulation of wound healing (GO:0061045)4.44623384
64* regulation of humoral immune response (GO:0002920)4.43732566
65bile acid and bile salt transport (GO:0015721)4.43555266
66imidazole-containing compound metabolic process (GO:0052803)4.42471550
67indolalkylamine metabolic process (GO:0006586)4.42408568
68plasma lipoprotein particle clearance (GO:0034381)4.41864050
69alkaloid metabolic process (GO:0009820)4.40873667
70negative regulation of coagulation (GO:0050819)4.38742348
71negative regulation of protein activation cascade (GO:2000258)4.38493891
72cellular biogenic amine catabolic process (GO:0042402)4.32985657
73amine catabolic process (GO:0009310)4.32985657
74cellular amino acid catabolic process (GO:0009063)4.30668973
75cellular glucuronidation (GO:0052695)4.28670392
76ethanol metabolic process (GO:0006067)4.24875815
77glutamate metabolic process (GO:0006536)4.24375413
78cholesterol efflux (GO:0033344)4.24009809
79serine family amino acid metabolic process (GO:0009069)4.21758078
80benzene-containing compound metabolic process (GO:0042537)4.15609297
81ethanol oxidation (GO:0006069)4.15567917
82positive regulation of hemostasis (GO:1900048)4.07698074
83positive regulation of blood coagulation (GO:0030194)4.07698074
84opsonization (GO:0008228)4.07250791
85cellular modified amino acid catabolic process (GO:0042219)4.06963633
86arginine metabolic process (GO:0006525)4.05578110
87serine family amino acid biosynthetic process (GO:0009070)4.04510379
88aldehyde catabolic process (GO:0046185)4.04210012
89dicarboxylic acid biosynthetic process (GO:0043650)4.03944705
90low-density lipoprotein particle remodeling (GO:0034374)4.03536562
91plasma lipoprotein particle assembly (GO:0034377)4.02592190
92acute inflammatory response (GO:0002526)4.00182158
93fibrinolysis (GO:0042730)3.98711970
94drug catabolic process (GO:0042737)3.91370694
95ketone body metabolic process (GO:1902224)3.90286112
96blood coagulation, intrinsic pathway (GO:0007597)3.85861059
97positive regulation of triglyceride metabolic process (GO:0090208)3.85552167
98positive regulation of lipoprotein lipase activity (GO:0051006)3.84768993
99positive regulation of triglyceride lipase activity (GO:0061365)3.84768993
100cofactor catabolic process (GO:0051187)3.84265737
101proline metabolic process (GO:0006560)3.81410198
102uronic acid metabolic process (GO:0006063)3.80491931
103glucuronate metabolic process (GO:0019585)3.80491931
104flavonoid metabolic process (GO:0009812)3.80081921
105protein-lipid complex subunit organization (GO:0071825)3.79414799
106negative regulation of lipase activity (GO:0060192)3.79019006
107very-low-density lipoprotein particle assembly (GO:0034379)3.78409502
108organic acid catabolic process (GO:0016054)3.76774712
109carboxylic acid catabolic process (GO:0046395)3.76774712
110positive regulation of coagulation (GO:0050820)3.75039251
111positive regulation of lipid catabolic process (GO:0050996)3.74548463
112cholesterol homeostasis (GO:0042632)3.74136089
113regulation of bile acid biosynthetic process (GO:0070857)3.70683576
114short-chain fatty acid metabolic process (GO:0046459)3.69981236
115regulation of apoptotic cell clearance (GO:2000425)3.69945187
116acetyl-CoA metabolic process (GO:0006084)3.69718918
117phospholipid homeostasis (GO:0055091)3.69031529
118sterol homeostasis (GO:0055092)3.67870961
119regulation of lipoprotein particle clearance (GO:0010984)3.67786782
120plasma lipoprotein particle organization (GO:0071827)3.64540817
121regulation of cholesterol homeostasis (GO:2000188)3.62525483
122NAD biosynthetic process (GO:0009435)3.62445575
123negative regulation of complement activation (GO:0045916)3.61843781
124* protein activation cascade (GO:0072376)3.60894277
125protein-lipid complex assembly (GO:0065005)3.60639770
126nicotinamide nucleotide biosynthetic process (GO:0019359)3.58260198
127pyridine nucleotide biosynthetic process (GO:0019363)3.58260198
128* complement activation (GO:0006956)3.56967820
129* complement activation, classical pathway (GO:0006958)3.56943666
130S-adenosylmethionine metabolic process (GO:0046500)3.56097763
131hormone catabolic process (GO:0042447)3.51566138
132positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.51061142
133intestinal cholesterol absorption (GO:0030299)3.48326071
134response to phenylpropanoid (GO:0080184)3.47122293
135regulation of triglyceride metabolic process (GO:0090207)3.46042624
136arginine catabolic process (GO:0006527)3.42341237

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.42407015
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.22960313
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.10238469
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.49533060
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.28540569
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.15103241
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.86841898
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.05428518
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.01175113
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.31586766
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07127920
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0154885
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98866372
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98325010
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62942361
16HTT_18923047_ChIP-ChIP_STHdh_Human1.58349383
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.57454351
18CLOCK_20551151_ChIP-Seq_293T_Human1.49324520
19GATA1_22025678_ChIP-Seq_K562_Human1.40247688
20HNF4A_19822575_ChIP-Seq_HepG2_Human1.39801114
21SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32394038
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32350516
23SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26745421
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24343921
25RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22675418
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16688907
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14277507
28CTCF_27219007_Chip-Seq_Bcells_Human1.11274825
29E2F1_20622854_ChIP-Seq_HELA_Human1.08923378
30TET1_21451524_ChIP-Seq_MESCs_Mouse1.07105553
31P68_20966046_ChIP-Seq_HELA_Human1.06663527
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04620216
33BCL6_27268052_Chip-Seq_Bcells_Human1.04458160
34SMC4_20622854_ChIP-Seq_HELA_Human1.03924345
35BCOR_27268052_Chip-Seq_Bcells_Human1.03902182
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02931006
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02006517
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00710852
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00350551
40SA1_27219007_Chip-Seq_Bcells_Human1.00181404
41ELF1_20517297_ChIP-Seq_JURKAT_Human0.98541797
42CTCF_20526341_ChIP-Seq_ESCs_Human0.97445642
43RACK7_27058665_Chip-Seq_MCF-7_Human0.92151338
44SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90276073
45PHF8_20622854_ChIP-Seq_HELA_Human0.88739596
46IRF8_22096565_ChIP-ChIP_GC-B_Human0.88231808
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87947259
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87760599
49ELK3_25401928_ChIP-Seq_HUVEC_Human0.86383807
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.83821745
51SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83144467
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82861241
53AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82712479
54RAC3_21632823_ChIP-Seq_H3396_Human0.81968749
55SA1_27219007_Chip-Seq_ERYTHROID_Human0.81740963
56KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80857488
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80661374
58RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80462767
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80197078
60GATA4_25053715_ChIP-Seq_YYC3_Human0.78772825
61SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77786809
62SOX2_21211035_ChIP-Seq_LN229_Human0.76954768
63* ERG_21242973_ChIP-ChIP_JURKAT_Human0.76950076
64EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.76542866
65SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76534170
66RARA_24833708_ChIP-Seq_LIVER_Mouse0.76495381
67JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.75201368
68ESR1_20079471_ChIP-ChIP_T-47D_Human0.74850905
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71543342
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70439558
71STAT6_21828071_ChIP-Seq_BEAS2B_Human0.70381196
72ZNF263_19887448_ChIP-Seq_K562_Human0.69956777
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69208618
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68920880
75RARB_24833708_ChIP-Seq_LIVER_Mouse0.67672580
76GATA3_21867929_ChIP-Seq_CD8_Mouse0.67661844
77VDR_21846776_ChIP-Seq_THP-1_Human0.66324891
78P300_27268052_Chip-Seq_Bcells_Human0.65400184
79SMC3_22415368_ChIP-Seq_MEFs_Mouse0.65187477
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64855043
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.64241380
82SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63930669
83CREB1_26743006_Chip-Seq_LNCaP_Human0.63893976
84* ERA_21632823_ChIP-Seq_H3396_Human0.63778205
85RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63278101
86P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.62588575
87CTCF_21964334_ChIP-Seq_BJAB-B_Human0.62537689
88BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62119657
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.61711479
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.60931187
91NRF2_20460467_ChIP-Seq_MEFs_Mouse0.60794505
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.60794505
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60743923
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.60722366
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.60588163
96BP1_19119308_ChIP-ChIP_Hs578T_Human0.60261829
97ESR2_21235772_ChIP-Seq_MCF-7_Human0.59827024
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59266482
99CEBPB_22108803_ChIP-Seq_LS180_Human0.58118434
100LXR_22292898_ChIP-Seq_THP-1_Human0.53844703
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53689005
102EGR1_19032775_ChIP-ChIP_M12_Human0.53509375
103AR_20517297_ChIP-Seq_VCAP_Human0.53421454
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53099553
105MYC_19915707_ChIP-ChIP_AK7_Human0.52594141
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.51866074
107FOXA1_25552417_ChIP-Seq_VCAP_Human0.51519840
108ESET_19884257_ChIP-Seq_ESCs_Mouse0.50564271
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50373812
110STAT1_17558387_ChIP-Seq_HELA_Human0.48857559
111FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48751480
112P53_21459846_ChIP-Seq_SAOS-2_Human0.48596748
113CBP_21632823_ChIP-Seq_H3396_Human0.47576602
114PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45431600
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44680709
116TAF15_26573619_Chip-Seq_HEK293_Human0.44146331
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43396931
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42971607
119TAF2_19829295_ChIP-Seq_ESCs_Human0.42603446
120GATA1_19941827_ChIP-Seq_MEL_Mouse0.41953561
121GATA1_19941826_ChIP-Seq_K562_Human0.39918961
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39811994
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.39731977
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.39670075
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.38520761
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38408354
127STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38396241
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.38030290
129BCAT_22108803_ChIP-Seq_LS180_Human0.37838196
130SPI1_26923725_Chip-Seq_HPCs_Mouse0.37705740
131GATA2_19941826_ChIP-Seq_K562_Human0.37624608
132MYC_27129775_Chip-Seq_CORNEA_Mouse0.37514101
133LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.37337100
134GATA6_25053715_ChIP-Seq_YYC3_Human0.36572186
135CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36204100
136SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36044220
137GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.35883283
138ERG_20517297_ChIP-Seq_VCAP_Human0.35270301
139NCOR_22424771_ChIP-Seq_293T_Human0.34443760
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.34342111
141SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.33888818
142GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.33485622
143FOXH1_21741376_ChIP-Seq_EPCs_Human0.33034734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.40786169
2MP0005360_urolithiasis7.55913441
3MP0005085_abnormal_gallbladder_physiolo6.43787531
4MP0005365_abnormal_bile_salt6.19286867
5MP0008875_abnormal_xenobiotic_pharmacok5.14064382
6MP0003806_abnormal_nucleotide_metabolis4.32874836
7MP0003252_abnormal_bile_duct3.89626798
8MP0010329_abnormal_lipoprotein_level3.60015437
9MP0009840_abnormal_foam_cell3.33787557
10MP0005083_abnormal_biliary_tract3.02016886
11MP0003195_calcinosis2.83400282
12MP0005332_abnormal_amino_acid2.76233242
13MP0001666_abnormal_nutrient_absorption2.60102316
14MP0003191_abnormal_cellular_cholesterol2.29660242
15MP0000609_abnormal_liver_physiology2.15869394
16MP0004019_abnormal_vitamin_homeostasis2.12298088
17MP0002118_abnormal_lipid_homeostasis2.10734629
18MP0003868_abnormal_feces_composition1.94839427
19MP0002138_abnormal_hepatobiliary_system1.94695579
20MP0005319_abnormal_enzyme/_coenzyme1.83535428
21MP0001764_abnormal_homeostasis1.70155840
22MP0009697_abnormal_copulation1.62773472
23MP0005584_abnormal_enzyme/coenzyme_acti1.57425931
24MP0005451_abnormal_body_composition1.45187168
25MP0003011_delayed_dark_adaptation1.36105331
26MP0003186_abnormal_redox_activity1.28015840
27MP0003656_abnormal_erythrocyte_physiolo1.24852348
28MP0009643_abnormal_urine_homeostasis1.23603158
29MP0000598_abnormal_liver_morphology1.17089750
30MP0003879_abnormal_hair_cell1.16980822
31MP0005647_abnormal_sex_gland1.16697198
32MP0003705_abnormal_hypodermis_morpholog1.11116087
33MP0000604_amyloidosis1.07833193
34MP0009764_decreased_sensitivity_to1.05595199
35MP0009763_increased_sensitivity_to1.01719697
36MP0002254_reproductive_system_inflammat0.97078447
37MP0010368_abnormal_lymphatic_system0.93769212
38MP0005636_abnormal_mineral_homeostasis0.93178461
39MP0008469_abnormal_protein_level0.89310097
40MP0009642_abnormal_blood_homeostasis0.87400250
41MP0006036_abnormal_mitochondrial_physio0.85670584
42MP0005408_hypopigmentation0.85044680
43MP0002876_abnormal_thyroid_physiology0.80847322
44MP0005376_homeostasis/metabolism_phenot0.80290563
45MP0002078_abnormal_glucose_homeostasis0.78327153
46MP0009765_abnormal_xenobiotic_induced0.78167589
47MP0005670_abnormal_white_adipose0.77859556
48MP0002089_abnormal_postnatal_growth/wei0.75514005
49MP0005084_abnormal_gallbladder_morpholo0.75010573
50MP0009785_altered_susceptibility_to0.73119910
51MP0005220_abnormal_exocrine_pancreas0.72493746
52MP0005167_abnormal_blood-brain_barrier0.72244928
53MP0002971_abnormal_brown_adipose0.71468157
54MP0005334_abnormal_fat_pad0.69252922
55MP0005535_abnormal_body_temperature0.67910437
56MP0004130_abnormal_muscle_cell0.65954072
57MP0005266_abnormal_metabolism0.65808179
58MP0001915_intracranial_hemorrhage0.65728486
59MP0003690_abnormal_glial_cell0.65416364
60MP0001661_extended_life_span0.64936533
61MP0002249_abnormal_larynx_morphology0.63727425
62MP0009053_abnormal_anal_canal0.63322372
63MP0003329_amyloid_beta_deposits0.63257517
64MP0000639_abnormal_adrenal_gland0.60594158
65MP0006035_abnormal_mitochondrial_morpho0.58422763
66MP0001756_abnormal_urination0.57955643
67MP0005448_abnormal_energy_balance0.55044297
68MP0005464_abnormal_platelet_physiology0.52570576
69MP0002282_abnormal_trachea_morphology0.51450818
70MP0002822_catalepsy0.51011629
71MP0000566_synostosis0.47978307
72MP0005395_other_phenotype0.47242612
73MP0010386_abnormal_urinary_bladder0.47176607
74MP0002332_abnormal_exercise_endurance0.46700280
75MP0003638_abnormal_response/metabolism_0.46654315
76MP0003718_maternal_effect0.46565715
77MP0002928_abnormal_bile_duct0.45651274
78MP0008874_decreased_physiological_sensi0.45446143
79MP0008873_increased_physiological_sensi0.45209246
80MP0005187_abnormal_penis_morphology0.44652356
81MP0002136_abnormal_kidney_physiology0.44113195
82MP0002837_dystrophic_cardiac_calcinosis0.43253237
83MP0004782_abnormal_surfactant_physiolog0.42692065
84MP0003953_abnormal_hormone_level0.41187241
85MP0003724_increased_susceptibility_to0.41087499
86MP0003436_decreased_susceptibility_to0.41053141
87MP0004381_abnormal_hair_follicle0.41009678
88MP0003075_altered_response_to0.39586881
89MP0005409_darkened_coat_color0.38994880
90MP0005248_abnormal_Harderian_gland0.38411541
91MP0008872_abnormal_physiological_respon0.38102182
92MP0005023_abnormal_wound_healing0.37956959
93MP0005166_decreased_susceptibility_to0.37822571
94MP0000003_abnormal_adipose_tissue0.36779867
95MP0009672_abnormal_birth_weight0.36578220
96MP0010155_abnormal_intestine_physiology0.36231308
97MP0005666_abnormal_adipose_tissue0.35211503
98MP0000467_abnormal_esophagus_morphology0.33462808
99MP0006082_CNS_inflammation0.33324743
100MP0003172_abnormal_lysosome_physiology0.32775928
101MP0009115_abnormal_fat_cell0.32630418
102MP0000579_abnormal_nail_morphology0.32293449
103MP0000249_abnormal_blood_vessel0.32001074
104MP0005375_adipose_tissue_phenotype0.31990054
105MP0001986_abnormal_taste_sensitivity0.31333236
106MP0002970_abnormal_white_adipose0.31257711
107MP0000230_abnormal_systemic_arterial0.31077255
108MP0002796_impaired_skin_barrier0.30641198
109MP0001243_abnormal_dermal_layer0.30403138
110MP0001853_heart_inflammation0.30132584
111MP0009333_abnormal_splenocyte_physiolog0.29984847
112MP0004883_abnormal_blood_vessel0.29442323
113MP0002168_other_aberrant_phenotype0.28812648
114MP0009384_cardiac_valve_regurgitation0.28675191
115MP0003183_abnormal_peptide_metabolism0.28444093
116MP0001845_abnormal_inflammatory_respons0.28097529
117MP0005025_abnormal_response_to0.27624338
118MP0001881_abnormal_mammary_gland0.26785092
119MP0002132_abnormal_respiratory_system0.24662672
120MP0005058_abnormal_lysosome_morphology0.23272212
121MP0005164_abnormal_response_to0.22955101
122MP0002090_abnormal_vision0.22423506

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.51149596
2Deep venous thrombosis (HP:0002625)7.43635323
3Intrahepatic cholestasis (HP:0001406)7.33039502
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.68970896
5Prolonged partial thromboplastin time (HP:0003645)6.58434067
6Hypobetalipoproteinemia (HP:0003563)6.50098363
7Xanthomatosis (HP:0000991)6.27245244
8Hyperlipoproteinemia (HP:0010980)5.68353928
9Complement deficiency (HP:0004431)5.34490382
10Hypolipoproteinemia (HP:0010981)4.80733357
11Joint hemorrhage (HP:0005261)4.80377793
12Hyperammonemia (HP:0001987)4.61842381
13Epidermoid cyst (HP:0200040)4.47825881
14Hyperglycinemia (HP:0002154)4.43885351
15Abnormality of the common coagulation pathway (HP:0010990)4.41799440
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.39859526
17Ketosis (HP:0001946)4.29502195
18Abnormality of methionine metabolism (HP:0010901)4.27173090
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.24407253
20Hypoalphalipoproteinemia (HP:0003233)4.16457334
21Fat malabsorption (HP:0002630)4.14318861
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.11923254
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09493929
24Hyperglycinuria (HP:0003108)3.93710251
25Nephritis (HP:0000123)3.93270210
26Abnormality of glycine metabolism (HP:0010895)3.91863772
27Abnormality of serine family amino acid metabolism (HP:0010894)3.91863772
28Hypoglycemic coma (HP:0001325)3.90328804
29Abnormality of complement system (HP:0005339)3.89413995
30Abnormality of pyrimidine metabolism (HP:0004353)3.86088374
31Abnormality of the intrinsic pathway (HP:0010989)3.80380731
32Conjugated hyperbilirubinemia (HP:0002908)3.68076308
33Hypercholesterolemia (HP:0003124)3.60086828
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.44189774
35Abnormality of fatty-acid metabolism (HP:0004359)3.40259753
36Hyperbilirubinemia (HP:0002904)3.36018099
37Steatorrhea (HP:0002570)3.15762030
38Delayed CNS myelination (HP:0002188)3.13549352
39Abnormality of serum amino acid levels (HP:0003112)3.08818987
40Abnormality of nucleobase metabolism (HP:0010932)3.06717963
41Ketoacidosis (HP:0001993)3.05706056
42Hypochromic microcytic anemia (HP:0004840)2.97788305
43Spontaneous abortion (HP:0005268)2.96994093
44Hepatocellular carcinoma (HP:0001402)2.95675382
45Myocardial infarction (HP:0001658)2.92411907
46Purpura (HP:0000979)2.82443671
47Abnormality of the Achilles tendon (HP:0005109)2.79797126
48Metabolic acidosis (HP:0001942)2.78702248
49Skin nodule (HP:0200036)2.75562432
50Systemic lupus erythematosus (HP:0002725)2.70924468
51Abnormality of purine metabolism (HP:0004352)2.67032757
52Lethargy (HP:0001254)2.62277670
53Dicarboxylic aciduria (HP:0003215)2.62141160
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62141160
55Vascular calcification (HP:0004934)2.59070657
56Hypoglycemic seizures (HP:0002173)2.49358068
57Abnormal gallbladder morphology (HP:0012437)2.49321284
58Acanthocytosis (HP:0001927)2.48092309
59Spastic diplegia (HP:0001264)2.47308029
60Cerebral edema (HP:0002181)2.43946318
61Gout (HP:0001997)2.42789521
62Mitral stenosis (HP:0001718)2.42609753
63Cholelithiasis (HP:0001081)2.42551590
64Abnormal gallbladder physiology (HP:0012438)2.39672062
65Cholecystitis (HP:0001082)2.39672062
66Glomerulonephritis (HP:0000099)2.37955189
67Neonatal onset (HP:0003623)2.36744025
68Recurrent gram-negative bacterial infections (HP:0005420)2.36667710
69Irritability (HP:0000737)2.35243500
70Pulmonary embolism (HP:0002204)2.30650875
71Cardiovascular calcification (HP:0011915)2.29223795
72Malnutrition (HP:0004395)2.28335944
73Amyloidosis (HP:0011034)2.25540108
74Reduced antithrombin III activity (HP:0001976)2.22559294
75Brushfield spots (HP:0001088)2.18689083
76Increased serum ferritin (HP:0003281)2.17202916
77Gingival bleeding (HP:0000225)2.17150593
78Late onset (HP:0003584)2.16646019
79Sensorimotor neuropathy (HP:0007141)2.16164724
80Menorrhagia (HP:0000132)2.16002462
81Esophageal varix (HP:0002040)2.14932193
82Pancreatitis (HP:0001733)2.14144687
83Enlarged kidneys (HP:0000105)2.11422800
84Cerebral palsy (HP:0100021)2.10698070
85Vomiting (HP:0002013)2.08368602
86Generalized aminoaciduria (HP:0002909)2.06610542
87Opisthotonus (HP:0002179)2.06031393
88Thrombophlebitis (HP:0004418)2.06010539
89Fair hair (HP:0002286)2.03466125
90Hyperinsulinemic hypoglycemia (HP:0000825)2.03444562
91Retinal atrophy (HP:0001105)2.03025180
92Abnormality of the gallbladder (HP:0005264)2.02926905
93Hemorrhage of the eye (HP:0011885)2.00057728
94Poikilocytosis (HP:0004447)1.99228543
95Osteomalacia (HP:0002749)1.96913112
96Elevated alkaline phosphatase (HP:0003155)1.96460260
97Rickets (HP:0002748)1.92444436
98Abnormality of iron homeostasis (HP:0011031)1.90357724
99Gangrene (HP:0100758)1.90006390
100Renal cortical cysts (HP:0000803)1.89714430
101Abnormal cartilage morphology (HP:0002763)1.88172292
102Joint swelling (HP:0001386)1.87837951
103Abnormality of transition element cation homeostasis (HP:0011030)1.87484474
104Arthropathy (HP:0003040)1.87064645
105Epistaxis (HP:0000421)1.86224269
106Abnormality of alkaline phosphatase activity (HP:0004379)1.85366753
107Hypophosphatemic rickets (HP:0004912)1.83159582
108Abnormality of proline metabolism (HP:0010907)1.82298118
109Hydroxyprolinuria (HP:0003080)1.82298118
110Elevated hepatic transaminases (HP:0002910)1.82050427
111Atrioventricular block (HP:0001678)1.81455811
112Abnormal enzyme/coenzyme activity (HP:0012379)1.80928229
113Alkalosis (HP:0001948)1.80261082
114Status epilepticus (HP:0002133)1.80129791
115Neonatal hypoglycemia (HP:0001998)1.78642397
116Abnormality of vitamin metabolism (HP:0100508)1.75381637
117Hyperphosphaturia (HP:0003109)1.74240898
118Hyperglycemia (HP:0003074)1.74115818
119Urinary glycosaminoglycan excretion (HP:0003541)1.73908597
120Mucopolysacchariduria (HP:0008155)1.73908597
121Hyperuricemia (HP:0002149)1.73679900
122Increased purine levels (HP:0004368)1.73679900
123J-shaped sella turcica (HP:0002680)1.72058490
124Potter facies (HP:0002009)1.71406834
125Facial shape deformation (HP:0011334)1.71406834
126Glycosuria (HP:0003076)1.70646004
127Abnormality of urine glucose concentration (HP:0011016)1.70646004
128Reticulocytosis (HP:0001923)1.70558403
129Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67603917
130Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67603917
131Abnormality of polysaccharide metabolism (HP:0011012)1.67603917

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.36236825
2SIK14.60936073
3FGFR44.60853316
4ERN14.46674294
5NTRK33.83404336
6TAOK33.08275007
7INSRR2.91191267
8ERBB42.82730665
9MAP2K42.40531419
10PKN22.29691467
11FLT32.03786325
12MST1R2.03039348
13PIK3CG1.90411261
14MAPK111.84774557
15TRIB31.78626282
16TYK21.72396796
17PRPF4B1.56847298
18LATS11.53416456
19ABL21.47652599
20DAPK21.47309500
21PTK61.46880485
22NEK91.36276496
23PDK21.32098890
24KDR1.32066318
25FRK1.30986017
26FGFR21.28874195
27JAK21.22003925
28PINK11.18704037
29MAP3K71.18057329
30MAP2K31.12525931
31PRKAA21.09368475
32TBK11.08429564
33GRK61.07959313
34ZAP701.07830192
35PIK3CA1.04485552
36MAPK151.00811006
37MAP3K140.99861551
38MAPK40.98554261
39JAK10.98495515
40MAP3K100.96466965
41ERBB20.94515299
42STK38L0.92085005
43MAP4K10.91912015
44PRKCZ0.91908932
45TNK20.87734830
46MAP3K30.81818169
47CDK60.80543794
48MAPK120.80211039
49MET0.79680022
50MAP3K110.79470593
51EPHB10.78594496
52TIE10.77591675
53SMG10.77498422
54PRKG20.77021564
55DYRK1B0.75808449
56PRKACG0.74962832
57MAP2K60.74241905
58EPHA30.72615001
59CAMK2G0.71246471
60CSK0.69385923
61MYLK0.68556582
62PRKACA0.66989490
63PRKG10.65574880
64GSK3A0.65323180
65PRKAA10.64566003
66CDC42BPA0.64438545
67CAMK1D0.63738506
68MAPKAPK30.62559481
69IRAK30.61417065
70PIM20.60976019
71PDGFRA0.59145124
72CSF1R0.58574194
73SGK30.58190299
74MAPK70.56655119
75IKBKE0.56071735
76RIPK10.55206066
77TGFBR20.54122049
78PRKCQ0.53828642
79PTK20.52579034
80FGFR30.52076609
81CSNK1G10.51951720
82TAOK10.51083204
83SIK30.51049980
84MAP3K130.49946480
85PDPK10.49606436
86CSNK1D0.48641669
87TAOK20.48313674
88SRC0.48171343
89DAPK30.46815769
90FES0.44624556
91GRK10.44402927
92RET0.43859415
93NTRK10.43632204
94IGF1R0.43159094
95ARAF0.42573253
96CDK40.42460870
97SIK20.41995167
98MAP3K50.41722757
99SGK20.41438742
100EPHA40.41267622
101BLK0.41212872
102MAPK30.41044377
103ICK0.40983200
104STK380.40861263
105MAP2K10.40173187
106PRKCG0.39619470
107AKT20.39041098
108MAP3K60.38859286
109PRKD20.38703515
110PRKCB0.38248060
111RPS6KC10.37445119
112RPS6KL10.37445119
113MAP3K120.37275367
114CAMKK10.34386484
115EPHB20.34212244
116FER0.34180114
117MUSK0.33248832
118PKN10.33181197
119CSNK1G30.32530046
120MTOR0.32402184
121CSNK1G20.32269802
122PDK40.32051641
123PDK30.32051641
124CAMK40.31733011
125EGFR0.31652129
126PDK10.31628028
127PBK0.28557323
128SGK4940.28458673
129SGK2230.28458673
130MAP3K10.25635188
131IRAK10.25307712
132PRKCA0.25131356
133IRAK20.23250445
134CSNK1A1L0.21182647
135MAP2K20.19960965
136ABL10.19334145
137LATS20.18656756
138KIT0.18186011

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.56995368
2Nitrogen metabolism_Homo sapiens_hsa009103.47093482
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37735459
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35418012
5Arginine biosynthesis_Homo sapiens_hsa002203.05087021
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70548168
7Tryptophan metabolism_Homo sapiens_hsa003802.70330121
8* Complement and coagulation cascades_Homo sapiens_hsa046102.67960243
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64587779
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54771030
11Fatty acid degradation_Homo sapiens_hsa000712.49193735
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39820067
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26611675
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15982743
15Butanoate metabolism_Homo sapiens_hsa006502.15273445
16Peroxisome_Homo sapiens_hsa041462.10392067
17Chemical carcinogenesis_Homo sapiens_hsa052041.97844720
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95587217
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.95143819
20Propanoate metabolism_Homo sapiens_hsa006401.94048873
21Histidine metabolism_Homo sapiens_hsa003401.91598716
22PPAR signaling pathway_Homo sapiens_hsa033201.86599118
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.80685949
24Fatty acid metabolism_Homo sapiens_hsa012121.80546285
25Caffeine metabolism_Homo sapiens_hsa002321.77651585
26Staphylococcus aureus infection_Homo sapiens_hsa051501.72955442
27Retinol metabolism_Homo sapiens_hsa008301.72834596
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72723609
29beta-Alanine metabolism_Homo sapiens_hsa004101.70762767
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67719554
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61404223
32Selenocompound metabolism_Homo sapiens_hsa004501.59622111
33Phenylalanine metabolism_Homo sapiens_hsa003601.56759135
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52869368
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50654294
36Bile secretion_Homo sapiens_hsa049761.48801782
37Tyrosine metabolism_Homo sapiens_hsa003501.45703290
38Pyruvate metabolism_Homo sapiens_hsa006201.38428479
39Sulfur metabolism_Homo sapiens_hsa009201.37830160
40Fatty acid elongation_Homo sapiens_hsa000621.34789160
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.32344562
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28148202
43Folate biosynthesis_Homo sapiens_hsa007901.24908391
44Biosynthesis of amino acids_Homo sapiens_hsa012301.20369414
45ABC transporters_Homo sapiens_hsa020101.18790587
46Steroid biosynthesis_Homo sapiens_hsa001001.16931616
47Fat digestion and absorption_Homo sapiens_hsa049751.16542704
48Carbon metabolism_Homo sapiens_hsa012001.13400578
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04741595
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.03226245
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.01017488
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98508985
53Sulfur relay system_Homo sapiens_hsa041220.97706219
54Arginine and proline metabolism_Homo sapiens_hsa003300.96453296
55Vitamin B6 metabolism_Homo sapiens_hsa007500.95648338
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87922600
57Vitamin digestion and absorption_Homo sapiens_hsa049770.83397639
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82294912
59Lysine degradation_Homo sapiens_hsa003100.80532004
60One carbon pool by folate_Homo sapiens_hsa006700.77159831
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71467412
62Glycerolipid metabolism_Homo sapiens_hsa005610.67346279
63Glutathione metabolism_Homo sapiens_hsa004800.66108427
64Pentose phosphate pathway_Homo sapiens_hsa000300.59133296
65Other glycan degradation_Homo sapiens_hsa005110.57189503
66Fatty acid biosynthesis_Homo sapiens_hsa000610.52755413
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48466490
68Metabolic pathways_Homo sapiens_hsa011000.46915391
69Pertussis_Homo sapiens_hsa051330.46255472
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43381567
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26748047
72Galactose metabolism_Homo sapiens_hsa000520.25868678
73Fructose and mannose metabolism_Homo sapiens_hsa000510.24431694
74Linoleic acid metabolism_Homo sapiens_hsa005910.24346176
75Insulin resistance_Homo sapiens_hsa049310.22316793
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.21004563
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18901176
78* Prion diseases_Homo sapiens_hsa050200.16299575
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.16131258
80Glucagon signaling pathway_Homo sapiens_hsa049220.09687569
81AMPK signaling pathway_Homo sapiens_hsa041520.01374190
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2548857
83Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2448459
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2402785
85Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2379273
86Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2246196
87* Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2242369
88Renin-angiotensin system_Homo sapiens_hsa04614-0.1949754
89Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1920424
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1892993
91Lysosome_Homo sapiens_hsa04142-0.1890397
92Hepatitis C_Homo sapiens_hsa05160-0.1852333
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1740576
94Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1544372
95Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1532784
96Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1518805
97African trypanosomiasis_Homo sapiens_hsa05143-0.1488063
98N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1312974
99Regulation of autophagy_Homo sapiens_hsa04140-0.1248918
100Serotonergic synapse_Homo sapiens_hsa04726-0.1204692
101Insulin signaling pathway_Homo sapiens_hsa04910-0.1056443
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0993947
103* Amoebiasis_Homo sapiens_hsa05146-0.0916552
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0789831
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0728091
106Sphingolipid metabolism_Homo sapiens_hsa00600-0.0594242
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0303093
108Mineral absorption_Homo sapiens_hsa04978-0.0016946

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