ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosome assembly (GO:0042255)	4.09372926
2	DNA damage response, detection of DNA damage (GO:0042769)	3.85921809
3	establishment of integrated proviral latency (GO:0075713)	3.79752007
4	DNA unwinding involved in DNA replication (GO:0006268)	3.78442705
5	DNA strand elongation involved in DNA replication (GO:0006271)	3.63916301
6	L-serine metabolic process (GO:0006563)	3.61109021
7	formation of translation preinitiation complex (GO:0001731)	3.59088074
8	peptidyl-arginine omega-N-methylation (GO:0035247)	3.54725166
9	regulation of translational fidelity (GO:0006450)	3.54686268
10	DNA strand elongation (GO:0022616)	3.54483334
11	regulation of mitochondrial translation (GO:0070129)	3.48273986
12	cullin deneddylation (GO:0010388)	3.46831612
13	ribosome biogenesis (GO:0042254)	3.45529834
14	spliceosomal snRNP assembly (GO:0000387)	3.44473449
15	protein targeting to mitochondrion (GO:0006626)	3.40370389
16	protein deneddylation (GO:0000338)	3.37390293
17	regulation of mitotic spindle organization (GO:0060236)	3.36906880
18	telomere maintenance via semi-conservative replication (GO:0032201)	3.29263112
19	purine nucleobase biosynthetic process (GO:0009113)	3.27259078
20	chaperone-mediated protein transport (GO:0072321)	3.25446097
21	peptidyl-arginine N-methylation (GO:0035246)	3.24019866
22	peptidyl-arginine methylation (GO:0018216)	3.24019866
23	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.20060558
24	tRNA aminoacylation for protein translation (GO:0006418)	3.19568403
25	oxidative phosphorylation (GO:0006119)	3.18922186
26	establishment of protein localization to mitochondrion (GO:0072655)	3.15183191
27	proteasome assembly (GO:0043248)	3.14698152
28	nucleobase biosynthetic process (GO:0046112)	3.12940450
29	tRNA aminoacylation (GO:0043039)	3.12017915
30	amino acid activation (GO:0043038)	3.12017915
31	protein localization to mitochondrion (GO:0070585)	3.11146391
32	histone arginine methylation (GO:0034969)	3.08717562
33	mitotic metaphase plate congression (GO:0007080)	3.06568693
34	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.06272498
35	establishment of viral latency (GO:0019043)	3.03172859
36	rRNA modification (GO:0000154)	3.03124588
37	ribonucleoprotein complex biogenesis (GO:0022613)	3.01982271
38	7-methylguanosine mRNA capping (GO:0006370)	3.00726082
39	maturation of 5.8S rRNA (GO:0000460)	2.99734064
40	DNA replication initiation (GO:0006270)	2.99286771
41	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.97972095
42	IMP biosynthetic process (GO:0006188)	2.97251477
43	mitotic sister chromatid segregation (GO:0000070)	2.95655573
44	mitotic chromosome condensation (GO:0007076)	2.92646645
45	nucleobase-containing small molecule interconversion (GO:0015949)	2.90728293
46	RNA capping (GO:0036260)	2.90503832
47	7-methylguanosine RNA capping (GO:0009452)	2.90503832
48	guanosine-containing compound biosynthetic process (GO:1901070)	2.89296378
49	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.88993831
50	ribosomal large subunit biogenesis (GO:0042273)	2.88863021
51	mitochondrial RNA metabolic process (GO:0000959)	2.87681369
52	DNA replication checkpoint (GO:0000076)	2.85842904
53	regulation of spindle organization (GO:0090224)	2.85657033
54	COPI coating of Golgi vesicle (GO:0048205)	2.85519893
55	Golgi transport vesicle coating (GO:0048200)	2.85519893
56	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.84071203
57	termination of RNA polymerase III transcription (GO:0006386)	2.82495174
58	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.82495174
59	rRNA processing (GO:0006364)	2.80456977
60	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.79810943
61	translesion synthesis (GO:0019985)	2.79773406
62	telomere maintenance via recombination (GO:0000722)	2.73970077
63	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.73963698
64	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.72425562
65	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.71360110
66	transcription-coupled nucleotide-excision repair (GO:0006283)	2.69827038
67	serine family amino acid biosynthetic process (GO:0009070)	2.69809835
68	negative regulation of mRNA processing (GO:0050686)	2.69643354
69	mitotic recombination (GO:0006312)	2.68236032
70	sister chromatid segregation (GO:0000819)	2.68194781
71	transcription from mitochondrial promoter (GO:0006390)	2.68056386
72	pseudouridine synthesis (GO:0001522)	2.67877951
73	CENP-A containing nucleosome assembly (GO:0034080)	2.67205280
74	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.66235417
75	rRNA metabolic process (GO:0016072)	2.65892084
76	double-strand break repair via nonhomologous end joining (GO:0006303)	2.65267076
77	non-recombinational repair (GO:0000726)	2.65267076
78	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.64564787
79	regulation of translational elongation (GO:0006448)	2.64066726
80	chromatin remodeling at centromere (GO:0031055)	2.63904861
81	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.63261696
82	base-excision repair (GO:0006284)	2.62601360
83	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.62457190
84	metaphase plate congression (GO:0051310)	2.62290715
85	inner mitochondrial membrane organization (GO:0007007)	2.61957556
86	nuclear pore complex assembly (GO:0051292)	2.60758806
87	GMP metabolic process (GO:0046037)	2.59707366
88	maturation of SSU-rRNA (GO:0030490)	2.59670110
89	regulation of retinoic acid receptor signaling pathway (GO:0048385)	2.59540783
90	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.59057140
91	cellular component biogenesis (GO:0044085)	2.58501876
92	protein complex localization (GO:0031503)	2.57197693
93	rRNA transcription (GO:0009303)	2.55689327
94	termination of RNA polymerase II transcription (GO:0006369)	2.53990371
95	folic acid-containing compound biosynthetic process (GO:0009396)	2.53619628
96	peptidyl-histidine modification (GO:0018202)	2.53612750
97	protein localization to chromosome, centromeric region (GO:0071459)	2.52983400
98	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.52573577
99	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.52357908
100	mitotic nuclear envelope disassembly (GO:0007077)	2.52078718

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.96702362
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.35374820
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.23754217
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	4.01450047
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.70595925
6	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.39544061
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.30057925
8	* GABP_17652178_ChIP-ChIP_JURKAT_Human	3.27976995
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.18455440
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.13276232
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	3.06977412
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.92918039
13	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.84344252
14	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.77032137
15	XRN2_22483619_ChIP-Seq_HELA_Human	2.74863856
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.67831904
17	* DCP1A_22483619_ChIP-Seq_HELA_Human	2.63750150
18	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.60261054
19	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.59963036
20	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.57335531
21	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.53897571
22	* GABP_19822575_ChIP-Seq_HepG2_Human	2.46281280
23	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.44088105
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.41082737
25	TTF2_22483619_ChIP-Seq_HELA_Human	2.38029886
26	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.24795403
27	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.22502886
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.18281239
29	MYCN_18555785_ChIP-Seq_MESCs_Mouse	2.18262669
30	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.13905844
31	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.10427010
32	ZFX_18555785_ChIP-Seq_MESCs_Mouse	2.10155014
33	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	2.08527738
34	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.07209245
35	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.04621003
36	* VDR_23849224_ChIP-Seq_CD4+_Human	1.95040986
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.94407497
38	ELK1_19687146_ChIP-ChIP_HELA_Human	1.91843680
39	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.90693769
40	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.88872286
41	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.87618961
42	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.80795073
43	ZNF263_19887448_ChIP-Seq_K562_Human	1.80421780
44	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.79843554
45	KDM5A_27292631_Chip-Seq_BREAST_Human	1.76801896
46	AR_21909140_ChIP-Seq_LNCAP_Human	1.76339470
47	* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.73130704
48	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.72171994
49	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.69220901
50	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.59153614
51	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.54439405
52	* PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.53305274
53	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.51716263
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45315886
55	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.43718402
56	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.38142319
57	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.36790043
58	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.33793798
59	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.33573001
60	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.33342999
61	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.30628818
62	CIITA_25753668_ChIP-Seq_RAJI_Human	1.30050777
63	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.29464414
64	MYC_18940864_ChIP-ChIP_HL60_Human	1.27546464
65	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.26362052
66	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.21134497
67	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.20951922
68	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.19871872
69	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.17980664
70	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.16518041
71	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.16105477
72	TFEB_21752829_ChIP-Seq_HELA_Human	1.15588522
73	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.13754740
74	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	1.13313622
75	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.13043124
76	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.12323974
77	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.12110100
78	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.04536751
79	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.04073603
80	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.04039862
81	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.99327573
82	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.93587106
83	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.92151817
84	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.91528729
85	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.91189105
86	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.90640860
87	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.88697946
88	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.86815775
89	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.86080662
90	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.85496321
91	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.84303958
92	IGF1R_20145208_ChIP-Seq_DFB_Human	0.84125476
93	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.83137059
94	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.82922949
95	CHD1_26751641_Chip-Seq_LNCaP_Human	0.82905834
96	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.82895869
97	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.82393182
98	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.79922128
99	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.78477743
100	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.78262277

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	3.88793372
2	MP0003693_abnormal_embryo_hatching	3.88696259
3	MP0008058_abnormal_DNA_repair	3.86352936
4	MP0003111_abnormal_nucleus_morphology	3.61237381
5	MP0003077_abnormal_cell_cycle	3.17453059
6	MP0004957_abnormal_blastocyst_morpholog	3.10758004
7	MP0008932_abnormal_embryonic_tissue	2.93026275
8	MP0008007_abnormal_cellular_replicative	2.41321737
9	MP0003786_premature_aging	2.00947257
10	MP0004233_abnormal_muscle_weight	1.92563767
11	MP0001661_extended_life_span	1.85645163
12	MP0001730_embryonic_growth_arrest	1.82144721
13	MP0006035_abnormal_mitochondrial_morpho	1.79292744
14	MP0000350_abnormal_cell_proliferation	1.77906750
15	MP0003718_maternal_effect	1.60068206
16	MP0006036_abnormal_mitochondrial_physio	1.57189560
17	MP0001529_abnormal_vocalization	1.53656974
18	MP0009697_abnormal_copulation	1.48031394
19	MP0001697_abnormal_embryo_size	1.47707386
20	MP0003186_abnormal_redox_activity	1.46075491
21	MP0000358_abnormal_cell_content/	1.44807694
22	MP0002080_prenatal_lethality	1.42262039
23	MP0001672_abnormal_embryogenesis/_devel	1.41820044
24	MP0005380_embryogenesis_phenotype	1.41820044
25	MP0008057_abnormal_DNA_replication	1.41426147
26	MP0002084_abnormal_developmental_patter	1.40764760
27	MP0000537_abnormal_urethra_morphology	1.35505198
28	MP0002085_abnormal_embryonic_tissue	1.29369917
29	MP0005171_absent_coat_pigmentation	1.27078185
30	MP0003937_abnormal_limbs/digits/tail_de	1.25126463
31	MP0003984_embryonic_growth_retardation	1.22690314
32	MP0003123_paternal_imprinting	1.21701512
33	MP0002088_abnormal_embryonic_growth/wei	1.16949163
34	MP0005394_taste/olfaction_phenotype	1.15667959
35	MP0005499_abnormal_olfactory_system	1.15667959
36	MP0000313_abnormal_cell_death	1.15429280
37	MP0000049_abnormal_middle_ear	1.13051294
38	MP0004197_abnormal_fetal_growth/weight/	1.11968152
39	MP0002210_abnormal_sex_determination	1.10343313
40	MP0002111_abnormal_tail_morphology	1.09822368
41	MP0003221_abnormal_cardiomyocyte_apopto	1.09450983
42	MP0010030_abnormal_orbit_morphology	1.08847829
43	MP0002160_abnormal_reproductive_system	1.08692336
44	MP0005501_abnormal_skin_physiology	1.07895892
45	MP0005623_abnormal_meninges_morphology	1.07711909
46	MP0008789_abnormal_olfactory_epithelium	1.07139530
47	MP0003385_abnormal_body_wall	1.06689861
48	MP0006292_abnormal_olfactory_placode	1.04678759
49	MP0004133_heterotaxia	1.03631425
50	MP0005187_abnormal_penis_morphology	1.02855990
51	MP0002697_abnormal_eye_size	1.02336181
52	MP0008260_abnormal_autophagy	1.00242162
53	MP0000647_abnormal_sebaceous_gland	0.99288573
54	MP0003567_abnormal_fetal_cardiomyocyte	0.98535316
55	MP0008995_early_reproductive_senescence	0.98488338
56	MP0001188_hyperpigmentation	0.98030636
57	MP0002736_abnormal_nociception_after	0.96633620
58	MP0001929_abnormal_gametogenesis	0.95708306
59	MP0000750_abnormal_muscle_regeneration	0.94553169
60	MP0009672_abnormal_birth_weight	0.94076978
61	MP0003861_abnormal_nervous_system	0.90340670
62	MP0001145_abnormal_male_reproductive	0.89710134
63	MP0003806_abnormal_nucleotide_metabolis	0.88008887
64	MP0003315_abnormal_perineum_morphology	0.87588185
65	MP0001727_abnormal_embryo_implantation	0.87227253
66	MP0002234_abnormal_pharynx_morphology	0.87031765
67	MP0001984_abnormal_olfaction	0.85710289
68	MP0002877_abnormal_melanocyte_morpholog	0.83597795
69	MP0000653_abnormal_sex_gland	0.83043536
70	MP0003755_abnormal_palate_morphology	0.82722227
71	MP0001346_abnormal_lacrimal_gland	0.81796213
72	MP0005384_cellular_phenotype	0.81174853
73	MP0003941_abnormal_skin_development	0.80635982
74	MP0004858_abnormal_nervous_system	0.78655691
75	MP0005423_abnormal_somatic_nervous	0.78191262
76	MP0002086_abnormal_extraembryonic_tissu	0.77107004
77	MP0003136_yellow_coat_color	0.76418292
78	MP0003698_abnormal_male_reproductive	0.75174490
79	MP0010307_abnormal_tumor_latency	0.72101291
80	MP0003115_abnormal_respiratory_system	0.71234380
81	MP0002233_abnormal_nose_morphology	0.70962479
82	MP0003942_abnormal_urinary_system	0.70767435
83	MP0000579_abnormal_nail_morphology	0.68873600
84	MP0001286_abnormal_eye_development	0.68863330
85	MP0003121_genomic_imprinting	0.68846530
86	MP0000013_abnormal_adipose_tissue	0.68638884
87	MP0009250_abnormal_appendicular_skeleto	0.68245401
88	MP0002282_abnormal_trachea_morphology	0.67730425
89	MP0002249_abnormal_larynx_morphology	0.67722050
90	MP0002161_abnormal_fertility/fecundity	0.67606086
91	MP0002751_abnormal_autonomic_nervous	0.67485511
92	MP0000751_myopathy	0.67164388
93	MP0002938_white_spotting	0.66435076
94	MP0006276_abnormal_autonomic_nervous	0.65786121
95	MP0002269_muscular_atrophy	0.64442878
96	MP0004811_abnormal_neuron_physiology	0.64053123
97	MP0001293_anophthalmia	0.63540993
98	MP0002184_abnormal_innervation	0.62915531
99	MP0000631_abnormal_neuroendocrine_gland	0.61414179
100	MP0009703_decreased_birth_body	0.61145457

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Microvesicular hepatic steatosis (HP:0001414)	3.85415901
2	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.25908612
3	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.25908612
4	Hepatocellular necrosis (HP:0001404)	3.19814260
5	Abnormality of glycolysis (HP:0004366)	3.09298893
6	Hepatic necrosis (HP:0002605)	2.92721382
7	Increased serum pyruvate (HP:0003542)	2.84021444
8	Progressive muscle weakness (HP:0003323)	2.78335223
9	Increased serum lactate (HP:0002151)	2.72982582
10	Increased CSF lactate (HP:0002490)	2.72707115
11	Abnormal mitochondria in muscle tissue (HP:0008316)	2.65046865
12	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.57882540
13	Multiple enchondromatosis (HP:0005701)	2.55809441
14	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.53629580
15	Ragged-red muscle fibers (HP:0003200)	2.50399818
16	Abnormality of the fetal cardiovascular system (HP:0010948)	2.49615023
17	Abnormal umbilical cord blood vessels (HP:0011403)	2.49615023
18	Single umbilical artery (HP:0001195)	2.49615023
19	Mitochondrial inheritance (HP:0001427)	2.49432752
20	Acute necrotizing encephalopathy (HP:0006965)	2.48557032
21	Lactic acidosis (HP:0003128)	2.41970025
22	Type I transferrin isoform profile (HP:0003642)	2.41657933
23	Chromsome breakage (HP:0040012)	2.38652478
24	Acute encephalopathy (HP:0006846)	2.37575634
25	Postnatal microcephaly (HP:0005484)	2.34273749
26	Abnormal protein glycosylation (HP:0012346)	2.25061767
27	Abnormal glycosylation (HP:0012345)	2.25061767
28	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.25061767
29	Abnormal protein N-linked glycosylation (HP:0012347)	2.25061767
30	Abnormality of the umbilical cord (HP:0010881)	2.21943854
31	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.20415490
32	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.15928590
33	Degeneration of anterior horn cells (HP:0002398)	2.13474282
34	Abnormality of the anterior horn cell (HP:0006802)	2.13474282
35	Lipid accumulation in hepatocytes (HP:0006561)	2.11702884
36	Increased hepatocellular lipid droplets (HP:0006565)	2.11344801
37	Hypoplastic pelvis (HP:0008839)	2.10775890
38	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.10244242
39	Meckel diverticulum (HP:0002245)	2.09301886
40	Cerebral edema (HP:0002181)	2.07394750
41	Increased intramyocellular lipid droplets (HP:0012240)	2.07094437
42	3-Methylglutaconic aciduria (HP:0003535)	2.06376910
43	Exercise intolerance (HP:0003546)	2.05914452
44	Proximal placement of thumb (HP:0009623)	2.04346270
45	Birth length less than 3rd percentile (HP:0003561)	2.04040720
46	Microretrognathia (HP:0000308)	2.03085408
47	Abnormality of the preputium (HP:0100587)	2.00677570
48	High anterior hairline (HP:0009890)	2.00534602
49	Abnormality of the ileum (HP:0001549)	1.99898375
50	Progressive external ophthalmoplegia (HP:0000590)	1.91653232
51	Increased nuchal translucency (HP:0010880)	1.90645756
52	Cortical dysplasia (HP:0002539)	1.90522978
53	Horseshoe kidney (HP:0000085)	1.89495800
54	Abnormal gallbladder physiology (HP:0012438)	1.88602398
55	Cholecystitis (HP:0001082)	1.88602398
56	Progressive macrocephaly (HP:0004481)	1.87082966
57	Abnormal number of erythroid precursors (HP:0012131)	1.86913948
58	Abnormality of alanine metabolism (HP:0010916)	1.84992584
59	Hyperalaninemia (HP:0003348)	1.84992584
60	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84992584
61	Absent radius (HP:0003974)	1.84477405
62	Increased muscle lipid content (HP:0009058)	1.82727296
63	Deviation of the thumb (HP:0009603)	1.82704750
64	Glossoptosis (HP:0000162)	1.81880418
65	Short 5th finger (HP:0009237)	1.81331553
66	Reduced antithrombin III activity (HP:0001976)	1.80012011
67	Retinal dysplasia (HP:0007973)	1.79992913
68	Aplasia involving forearm bones (HP:0009822)	1.77482091
69	Absent forearm bone (HP:0003953)	1.77482091
70	Absent epiphyses (HP:0010577)	1.77061297
71	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.77061297
72	Hypokinesia (HP:0002375)	1.75435989
73	Respiratory failure (HP:0002878)	1.75363268
74	Testicular atrophy (HP:0000029)	1.72662158
75	Facial cleft (HP:0002006)	1.72382061
76	Cerebral hypomyelination (HP:0006808)	1.71480842
77	Premature ovarian failure (HP:0008209)	1.71373387
78	Reticulocytopenia (HP:0001896)	1.71350328
79	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	1.71281483
80	Double outlet right ventricle (HP:0001719)	1.71023076
81	Congenital malformation of the right heart (HP:0011723)	1.71023076
82	Abnormality of cells of the erythroid lineage (HP:0012130)	1.70078055
83	Shoulder girdle muscle weakness (HP:0003547)	1.67904112
84	Abnormalities of placenta or umbilical cord (HP:0001194)	1.67062933
85	Broad distal phalanx of finger (HP:0009836)	1.66666600
86	Secondary amenorrhea (HP:0000869)	1.66650179
87	CNS demyelination (HP:0007305)	1.65937968
88	Insomnia (HP:0100785)	1.64449505
89	Short tibia (HP:0005736)	1.64244418
90	Abnormality of the carotid arteries (HP:0005344)	1.59221426
91	Selective tooth agenesis (HP:0001592)	1.58968527
92	Emotional lability (HP:0000712)	1.57317864
93	Preaxial hand polydactyly (HP:0001177)	1.56099700
94	Dicarboxylic aciduria (HP:0003215)	1.54539755
95	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.54539755
96	Microglossia (HP:0000171)	1.54138535
97	Overriding aorta (HP:0002623)	1.53039283
98	Progressive microcephaly (HP:0000253)	1.52147199
99	Abnormal number of incisors (HP:0011064)	1.51303510
100	Overlapping toe (HP:0001845)	1.49796185

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	3.90679022
2	SRPK1	3.59983751
3	PBK	3.46198317
4	CDC7	2.85753391
5	NME2	2.83338506
6	VRK2	2.65590301
7	NEK1	2.59384218
8	TTK	2.47297526
9	TSSK6	2.17929705
10	PDK2	2.16016471
11	EIF2AK1	2.10437056
12	STK16	1.97201480
13	PIM2	1.85258841
14	NME1	1.81165568
15	SCYL2	1.81006884
16	BCKDK	1.64533600
17	CSNK1G3	1.60197262
18	WEE1	1.59964928
19	RPS6KA4	1.49239676
20	TESK2	1.47323715
21	CSNK1A1L	1.42866758
22	PLK1	1.42830175
23	BRSK1	1.42725577
24	BCR	1.36230099
25	CCNB1	1.35861304
26	CDK7	1.35703339
27	ICK	1.34311303
28	TRIM28	1.31452390
29	CHEK2	1.31052305
30	EIF2AK3	1.27357118
31	AURKB	1.26643805
32	CSNK1G1	1.25920022
33	TESK1	1.24105929
34	ATR	1.22961725
35	PLK3	1.19789988
36	PLK4	1.18969984
37	AURKA	1.17341048
38	IRAK3	1.15968354
39	CSNK1G2	1.12070966
40	MAP2K7	1.11933321
41	PRKD3	1.11047805
42	MST1R	1.10018283
43	PAK4	1.06257239
44	BRD4	1.02153151
45	ZAK	1.02038353
46	MKNK1	1.00594546
47	CHEK1	1.00132840
48	ERBB4	0.98623375
49	BRSK2	0.95017228
50	NEK9	0.94552845
51	EEF2K	0.92027638
52	EIF2AK2	0.91832088
53	SMG1	0.91775138
54	VRK1	0.85688711
55	LIMK1	0.83508508
56	DAPK1	0.83422748
57	PKN2	0.83330222
58	EPHA2	0.82495019
59	CDK19	0.81227499
60	AKT2	0.76063225
61	BRAF	0.75635506
62	CDK8	0.74275137
63	MAP4K2	0.73758429
64	ATM	0.72971946
65	MAP3K4	0.67983311
66	CDK14	0.67657972
67	DYRK3	0.64696126
68	MET	0.63588000
69	CDK2	0.62919284
70	CDK11A	0.62532881
71	RPS6KA5	0.62200853
72	CDK12	0.62042454
73	RPS6KB2	0.60206953
74	DYRK2	0.59133618
75	CDK1	0.58728682
76	CDK18	0.55412367
77	TAF1	0.54826535
78	LMTK2	0.54216358
79	CSNK2A1	0.54169847
80	CLK1	0.53431759
81	ILK	0.53398679
82	CSNK1E	0.53299603
83	CSNK2A2	0.52257348
84	ARAF	0.52166629
85	CDK15	0.51687060
86	NUAK1	0.47755653
87	AKT3	0.46427713
88	PRKCI	0.45756121
89	MARK1	0.44586615
90	PHKG1	0.44502198
91	PHKG2	0.44502198
92	ALK	0.43942668
93	CDK6	0.43019470
94	CDK4	0.42503996
95	CDK9	0.40614702
96	PAK6	0.40417773
97	FLT3	0.40328310
98	NEK6	0.38603208
99	RAF1	0.38010103
100	MST4	0.37277594

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.55095991
2	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.88000061
3	Mismatch repair_Homo sapiens_hsa03430	2.87177929
4	Base excision repair_Homo sapiens_hsa03410	2.82284503
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.77294912
6	RNA polymerase_Homo sapiens_hsa03020	2.72927529
7	Spliceosome_Homo sapiens_hsa03040	2.62106532
8	Proteasome_Homo sapiens_hsa03050	2.45856314
9	Ribosome_Homo sapiens_hsa03010	2.32342382
10	RNA transport_Homo sapiens_hsa03013	2.26890511
11	Fatty acid elongation_Homo sapiens_hsa00062	2.19584804
12	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.10802952
13	Nucleotide excision repair_Homo sapiens_hsa03420	2.04231750
14	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.02818053
15	Homologous recombination_Homo sapiens_hsa03440	1.99339892
16	Pyrimidine metabolism_Homo sapiens_hsa00240	1.99116998
17	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.95913873
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.94784725
19	One carbon pool by folate_Homo sapiens_hsa00670	1.90874751
20	Protein export_Homo sapiens_hsa03060	1.90573921
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.69647553
22	Parkinsons disease_Homo sapiens_hsa05012	1.69253208
23	Cell cycle_Homo sapiens_hsa04110	1.68923887
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.65948101
25	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.63706681
26	Carbon metabolism_Homo sapiens_hsa01200	1.62943249
27	Pyruvate metabolism_Homo sapiens_hsa00620	1.59555726
28	Sulfur relay system_Homo sapiens_hsa04122	1.58675297
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.53348428
30	mRNA surveillance pathway_Homo sapiens_hsa03015	1.52268526
31	Folate biosynthesis_Homo sapiens_hsa00790	1.45405161
32	Basal transcription factors_Homo sapiens_hsa03022	1.43541016
33	Huntingtons disease_Homo sapiens_hsa05016	1.42389596
34	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.41304655
35	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.40792406
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.40673193
37	Pentose phosphate pathway_Homo sapiens_hsa00030	1.39845835
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34430429
39	RNA degradation_Homo sapiens_hsa03018	1.32911205
40	Purine metabolism_Homo sapiens_hsa00230	1.26007593
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.25915954
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.19705010
43	Sulfur metabolism_Homo sapiens_hsa00920	1.16040811
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.14970290
45	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.14813453
46	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.13554797
47	Fatty acid metabolism_Homo sapiens_hsa01212	1.13035835
48	Propanoate metabolism_Homo sapiens_hsa00640	1.11960836
49	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.94618219
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.94030977
51	Alzheimers disease_Homo sapiens_hsa05010	0.94005267
52	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.87652782
53	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.87297655
54	Glutathione metabolism_Homo sapiens_hsa00480	0.86704663
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.83769744
56	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.82159542
57	Oocyte meiosis_Homo sapiens_hsa04114	0.81972760
58	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.80033862
59	Butanoate metabolism_Homo sapiens_hsa00650	0.75178473
60	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.73933346
61	Lysine degradation_Homo sapiens_hsa00310	0.73787714
62	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.70303232
63	Metabolic pathways_Homo sapiens_hsa01100	0.67820189
64	Arginine and proline metabolism_Homo sapiens_hsa00330	0.62461431
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59820802
66	Vibrio cholerae infection_Homo sapiens_hsa05110	0.57724405
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56682436
68	p53 signaling pathway_Homo sapiens_hsa04115	0.55251183
69	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.53708132
70	Cardiac muscle contraction_Homo sapiens_hsa04260	0.48957998
71	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.45574293
72	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.44714829
73	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.41083687
74	Peroxisome_Homo sapiens_hsa04146	0.39366202
75	Hippo signaling pathway_Homo sapiens_hsa04390	0.37821306
76	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.37448983
77	Phenylalanine metabolism_Homo sapiens_hsa00360	0.33181215
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.32730648
79	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.32417237
80	Arginine biosynthesis_Homo sapiens_hsa00220	0.32255133
81	Fatty acid degradation_Homo sapiens_hsa00071	0.30591566
82	Galactose metabolism_Homo sapiens_hsa00052	0.28732804
83	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.26513925
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24556641
85	Regulation of autophagy_Homo sapiens_hsa04140	0.23856475
86	Alcoholism_Homo sapiens_hsa05034	0.23807431
87	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.23152150
88	Tyrosine metabolism_Homo sapiens_hsa00350	0.22834093
89	AMPK signaling pathway_Homo sapiens_hsa04152	0.19624809
90	Bladder cancer_Homo sapiens_hsa05219	0.19087641
91	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.17926089
92	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.15801410
93	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.14314226
94	Basal cell carcinoma_Homo sapiens_hsa05217	0.14221556
95	Nicotine addiction_Homo sapiens_hsa05033	0.14029968
96	Thyroid cancer_Homo sapiens_hsa05216	0.13774859
97	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.13457365
98	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.11976866
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.10737902
100	Circadian rhythm_Homo sapiens_hsa04710	0.09308691

C8ORF33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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