C8ORF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of complement activation (GO:0045916)6.62216844
2negative regulation of protein activation cascade (GO:2000258)6.47585678
3surfactant homeostasis (GO:0043129)6.40444670
4regulation of complement activation (GO:0030449)5.61388224
5regulation of protein activation cascade (GO:2000257)5.47349280
6chemical homeostasis within a tissue (GO:0048875)5.33355821
7negative regulation of humoral immune response (GO:0002921)5.07093397
8complement activation, classical pathway (GO:0006958)4.58192440
9intestinal cholesterol absorption (GO:0030299)4.43981855
10complement activation (GO:0006956)3.99626920
11complement activation, alternative pathway (GO:0006957)3.95047332
12doxorubicin metabolic process (GO:0044598)3.74110147
13daunorubicin metabolic process (GO:0044597)3.74110147
14polyketide metabolic process (GO:0030638)3.74110147
15protein activation cascade (GO:0072376)3.73848981
16lung vasculature development (GO:0060426)3.69907579
17lung lobe morphogenesis (GO:0060463)3.51104283
18calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.51043677
19negative regulation of fibrinolysis (GO:0051918)3.42923404
20positive regulation of extracellular matrix organization (GO:1903055)3.37779895
21regulation of apoptotic cell clearance (GO:2000425)3.36810541
22aminoglycoside antibiotic metabolic process (GO:0030647)3.33530985
23bundle of His cell to Purkinje myocyte communication (GO:0086069)3.32483158
24positive regulation of p38MAPK cascade (GO:1900745)3.25877642
25regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.15756019
26regulation of transforming growth factor beta1 production (GO:0032908)3.11337727
27endothelial cell chemotaxis (GO:0035767)3.08143990
28endocrine hormone secretion (GO:0060986)3.07974061
29regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.07185521
30retinal metabolic process (GO:0042574)3.01128979
31regulation of fibrinolysis (GO:0051917)2.99077542
32nephron tubule formation (GO:0072079)2.98556221
33L-phenylalanine metabolic process (GO:0006558)2.97937199
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.97937199
35intestinal absorption (GO:0050892)2.97283445
36acute-phase response (GO:0006953)2.97273546
37regulation of humoral immune response (GO:0002920)2.95594099
38glomerular filtration (GO:0003094)2.94875143
39transepithelial transport (GO:0070633)2.93930575
40positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.93289832
41L-phenylalanine catabolic process (GO:0006559)2.92266968
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.92266968
43ethanol oxidation (GO:0006069)2.92137817
44cell adhesion mediated by integrin (GO:0033627)2.88527136
45skin morphogenesis (GO:0043589)2.83152347
46blood coagulation, intrinsic pathway (GO:0007597)2.80778543
47cell proliferation involved in kidney development (GO:0072111)2.80028899
48renal filtration (GO:0097205)2.78245413
49positive regulation of transforming growth factor beta production (GO:0071636)2.74030004
50glomerular basement membrane development (GO:0032836)2.72450788
51desmosome organization (GO:0002934)2.64276246
52regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.60691044
53protein carboxylation (GO:0018214)2.58146226
54peptidyl-glutamic acid carboxylation (GO:0017187)2.58146226
55heart valve morphogenesis (GO:0003179)2.56697007
56positive regulation of osteoblast proliferation (GO:0033690)2.56422435
57protein-lipid complex remodeling (GO:0034368)2.56398200
58macromolecular complex remodeling (GO:0034367)2.56398200
59plasma lipoprotein particle remodeling (GO:0034369)2.56398200
60regulation of p38MAPK cascade (GO:1900744)2.56377974
61low-density lipoprotein particle remodeling (GO:0034374)2.56253285
62fibrinolysis (GO:0042730)2.54104215
63acute inflammatory response (GO:0002526)2.53791886
64notochord development (GO:0030903)2.52521206
65peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.51968018
66negative regulation of coagulation (GO:0050819)2.51503712
67high-density lipoprotein particle remodeling (GO:0034375)2.50999225
68positive regulation of chemokine secretion (GO:0090197)2.50559354
69negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.48363552
70neural crest cell development (GO:0014032)2.48066607
71regulation of plasminogen activation (GO:0010755)2.47983997
72very-low-density lipoprotein particle assembly (GO:0034379)2.47719411
73regulation of transforming growth factor beta production (GO:0071634)2.47421370
74retina vasculature morphogenesis in camera-type eye (GO:0061299)2.46932735
75lipoprotein metabolic process (GO:0042157)2.46357510
76negative regulation of blood coagulation (GO:0030195)2.45409033
77negative regulation of hemostasis (GO:1900047)2.45409033
78regulation of cholesterol esterification (GO:0010872)2.43303979
79renal absorption (GO:0070293)2.41820468
80negative regulation of dendrite morphogenesis (GO:0050774)2.40264266
81primary alcohol catabolic process (GO:0034310)2.39920834
82regulation of cholesterol homeostasis (GO:2000188)2.37104577
83ethanol metabolic process (GO:0006067)2.36944933
84reverse cholesterol transport (GO:0043691)2.36719995
85regulation of chemokine secretion (GO:0090196)2.36315191
86sterol transport (GO:0015918)2.36020457
87cholesterol transport (GO:0030301)2.36020457
88establishment of endothelial barrier (GO:0061028)2.34999180
89positive regulation of astrocyte differentiation (GO:0048711)2.34353383
90ovulation from ovarian follicle (GO:0001542)2.33718713
91cell migration involved in sprouting angiogenesis (GO:0002042)2.33047726
92phosphate ion transmembrane transport (GO:0035435)2.32210460
93triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.31559658
94negative regulation of fatty acid transport (GO:2000192)2.30497218
95basement membrane organization (GO:0071711)2.30242327
96tonic smooth muscle contraction (GO:0014820)2.29532143
97regulation of systemic arterial blood pressure by hormone (GO:0001990)2.28933034
98regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.28933034
99endocrine process (GO:0050886)2.28933034
100negative regulation of wound healing (GO:0061045)2.28931194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.88743106
2* TRIM28_21343339_ChIP-Seq_HEK293_Human3.70499536
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.67734535
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.67025246
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.17531451
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.86050029
7* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.66173600
8ZNF217_24962896_ChIP-Seq_MCF-7_Human2.62854715
9CDX2_20551321_ChIP-Seq_CACO-2_Human2.50022684
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.47556798
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46666521
12CLOCK_20551151_ChIP-Seq_293T_Human2.37891003
13PPAR_26484153_Chip-Seq_NCI-H1993_Human2.36213672
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.30988900
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.21307007
16CJUN_26792858_Chip-Seq_BT549_Human2.19935976
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.16343701
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.13865961
19FOXO3_23340844_ChIP-Seq_DLD1_Human2.09168688
20SALL4_18804426_ChIP-ChIP_XEN_Mouse2.08575892
21SOX2_20726797_ChIP-Seq_SW620_Human1.95510678
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.93303839
23TCF4_18268006_ChIP-ChIP_LS174T_Human1.91019847
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86004225
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85706173
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80672268
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79810162
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.77673715
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.76150889
30* GATA4_25053715_ChIP-Seq_YYC3_Human1.75550619
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.75100665
32AHR_22903824_ChIP-Seq_MCF-7_Human1.74966210
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.73390514
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.72439127
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.71463449
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67943041
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65119599
38SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.64366883
39SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.64366883
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62044081
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.57118381
42NFIB_24661679_ChIP-Seq_LUNG_Mouse1.56704745
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47945150
44* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46563733
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.44530092
46* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.40941758
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39551350
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39551350
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38565915
50GATA6_25053715_ChIP-Seq_YYC3_Human1.37833249
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37788674
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.36386355
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31705677
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29863211
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29842473
56TP53_18474530_ChIP-ChIP_U2OS_Human1.28859569
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27760462
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24743097
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23841784
60TP53_16413492_ChIP-PET_HCT116_Human1.23583952
61* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22747128
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21982465
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20259036
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17705077
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16824519
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16722932
67* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16278559
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15391016
69* GATA3_24758297_ChIP-Seq_MCF-7_Human1.13751812
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10150423
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08881831
72* SMAD3_21741376_ChIP-Seq_HESCs_Human1.06684779
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06342992
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03046413
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01531563
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.01462385
77TBX20_22080862_ChIP-Seq_HEART_Mouse1.01462385
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00898165
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00647173
80* RUNX1_27514584_Chip-Seq_MCF-7_Human0.99153849
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98258456
82TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95973658
83ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95911039
84TP63_23658742_ChIP-Seq_EP156T_Human0.94304472
85* HNF4A_19822575_ChIP-Seq_HepG2_Human0.94032510
86WT1_19549856_ChIP-ChIP_CCG9911_Human0.93138726
87EGR1_19374776_ChIP-ChIP_THP-1_Human0.89807905
88KLF5_25053715_ChIP-Seq_YYC3_Human0.88643943
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88203349
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87321446
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86238285
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86146419
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86086675
94PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85535216
95* FOXA1_25552417_ChIP-Seq_VCAP_Human0.85215578
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82558386
97* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82374026
98BRD4_25478319_ChIP-Seq_HGPS_Human0.80091673
99EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79514298
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.79494572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.80023908
2MP0004782_abnormal_surfactant_physiolog3.67609276
3MP0002138_abnormal_hepatobiliary_system3.36066877
4MP0010368_abnormal_lymphatic_system3.35801277
5MP0005365_abnormal_bile_salt3.16700112
6MP0004272_abnormal_basement_membrane2.85162596
7MP0005085_abnormal_gallbladder_physiolo2.59883727
8MP0001958_emphysema2.57919271
9MP0008438_abnormal_cutaneous_collagen2.48068866
10MP0001666_abnormal_nutrient_absorption2.41818898
11MP0003566_abnormal_cell_adhesion2.39686753
12MP0005023_abnormal_wound_healing2.30336259
13MP0001879_abnormal_lymphatic_vessel2.21365498
14MP0003252_abnormal_bile_duct2.17057392
15MP0005503_abnormal_tendon_morphology2.15270535
16MP0005275_abnormal_skin_tensile2.05214315
17MP0003868_abnormal_feces_composition2.03502223
18MP0003950_abnormal_plasma_membrane1.95884021
19MP0003300_gastrointestinal_ulcer1.92300998
20MP0005670_abnormal_white_adipose1.90373048
21MP0009840_abnormal_foam_cell1.88752303
22MP0010352_gastrointestinal_tract_polyps1.85785602
23MP0000566_synostosis1.77362111
24MP0003195_calcinosis1.75520965
25MP0005360_urolithiasis1.68837012
26MP0006138_congestive_heart_failure1.65324847
27MP0005083_abnormal_biliary_tract1.61814046
28MP0004264_abnormal_extraembryonic_tissu1.58621547
29MP0010386_abnormal_urinary_bladder1.54635269
30MP0003091_abnormal_cell_migration1.52773841
31MP0008875_abnormal_xenobiotic_pharmacok1.49258484
32MP0006054_spinal_hemorrhage1.48098284
33MP0005167_abnormal_blood-brain_barrier1.47239883
34MP0008004_abnormal_stomach_pH1.47201940
35MP0005164_abnormal_response_to1.45679164
36MP0002295_abnormal_pulmonary_circulatio1.39967166
37MP0009780_abnormal_chondrocyte_physiolo1.38574643
38MP0002282_abnormal_trachea_morphology1.29835494
39MP0002108_abnormal_muscle_morphology1.24332287
40MP0000013_abnormal_adipose_tissue1.24049013
41MP0010329_abnormal_lipoprotein_level1.22643359
42MP0003828_pulmonary_edema1.22176762
43MP0005332_abnormal_amino_acid1.21604075
44MP0001756_abnormal_urination1.17830421
45MP0009643_abnormal_urine_homeostasis1.17698488
46MP0002876_abnormal_thyroid_physiology1.17173823
47MP0004019_abnormal_vitamin_homeostasis1.16990046
48MP0005076_abnormal_cell_differentiation1.16888786
49MP0005084_abnormal_gallbladder_morpholo1.16565480
50MP0003943_abnormal_hepatobiliary_system1.15961661
51MP0002133_abnormal_respiratory_system1.15883725
52MP0005388_respiratory_system_phenotype1.15883725
53MP0000767_abnormal_smooth_muscle1.12637691
54MP0002896_abnormal_bone_mineralization1.12384763
55MP0004084_abnormal_cardiac_muscle1.12192109
56MP0000249_abnormal_blood_vessel1.07410613
57MP0000537_abnormal_urethra_morphology1.06204222
58MP0005166_decreased_susceptibility_to1.05676644
59MP0001851_eye_inflammation1.05619613
60MP0000383_abnormal_hair_follicle1.03985093
61MP0005165_increased_susceptibility_to1.02445619
62MP0000762_abnormal_tongue_morphology1.01400172
63MP0008775_abnormal_heart_ventricle0.99603955
64MP0010678_abnormal_skin_adnexa0.96624947
65MP0002928_abnormal_bile_duct0.96074920
66MP0002168_other_aberrant_phenotype0.95593511
67MP0002166_altered_tumor_susceptibility0.94379683
68MP0001614_abnormal_blood_vessel0.92213996
69MP0005595_abnormal_vascular_smooth0.91073984
70MP0000534_abnormal_ureter_morphology0.89281590
71MP0004484_altered_response_of0.87519854
72MP0002877_abnormal_melanocyte_morpholog0.87119984
73MP0002118_abnormal_lipid_homeostasis0.87090099
74MP0004043_abnormal_pH_regulation0.86842670
75MP0000003_abnormal_adipose_tissue0.86370162
76MP0003941_abnormal_skin_development0.86191393
77MP0005257_abnormal_intraocular_pressure0.85590322
78MP0002136_abnormal_kidney_physiology0.84434314
79MP0009384_cardiac_valve_regurgitation0.84267952
80MP0003724_increased_susceptibility_to0.83937241
81MP0002925_abnormal_cardiovascular_devel0.82730063
82MP0002933_joint_inflammation0.81678590
83MP0003279_aneurysm0.75799345
84MP0010234_abnormal_vibrissa_follicle0.75567620
85MP0002132_abnormal_respiratory_system0.74895591
86MP0000467_abnormal_esophagus_morphology0.74861239
87MP0003191_abnormal_cellular_cholesterol0.74547743
88MP0002128_abnormal_blood_circulation0.74157021
89MP0005409_darkened_coat_color0.73303195
90MP0005220_abnormal_exocrine_pancreas0.73003438
91MP0004883_abnormal_blood_vessel0.72060622
92MP0010030_abnormal_orbit_morphology0.71626061
93MP0003453_abnormal_keratinocyte_physiol0.71122660
94MP0005623_abnormal_meninges_morphology0.68762688
95MP0000627_abnormal_mammary_gland0.68498437
96MP0001542_abnormal_bone_strength0.68466241
97MP0000613_abnormal_salivary_gland0.66516318
98MP0005187_abnormal_penis_morphology0.65758892
99MP0005508_abnormal_skeleton_morphology0.65168765
100MP0001502_abnormal_circadian_rhythm0.64444915

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)5.91108173
2Interstitial pulmonary disease (HP:0006530)4.98658144
3Deep venous thrombosis (HP:0002625)4.95797725
4Abnormality of complement system (HP:0005339)4.75009001
5Systemic lupus erythematosus (HP:0002725)4.65994008
6Glomerulonephritis (HP:0000099)4.52092198
7Right ventricular cardiomyopathy (HP:0011663)4.05642962
8Nephritis (HP:0000123)3.83285479
9Vascular calcification (HP:0004934)3.77571917
10Arterial tortuosity (HP:0005116)3.62881383
11Cardiovascular calcification (HP:0011915)3.62331501
12Vascular tortuosity (HP:0004948)3.51014926
13Abnormality of monocarboxylic acid metabolism (HP:0010996)3.44349970
14Abnormality of the nasal septum (HP:0000419)3.42294112
15Prolonged partial thromboplastin time (HP:0003645)3.41242585
16Fat malabsorption (HP:0002630)3.11284405
17Aortic aneurysm (HP:0004942)3.09599959
18Tubulointerstitial fibrosis (HP:0005576)3.09229079
19Neonatal short-limb short stature (HP:0008921)3.08345874
20Aortic dissection (HP:0002647)3.04278864
21Mitral stenosis (HP:0001718)2.94873015
22Hypobetalipoproteinemia (HP:0003563)2.89695113
23Joint hemorrhage (HP:0005261)2.89330857
24Conjugated hyperbilirubinemia (HP:0002908)2.84139713
25Focal segmental glomerulosclerosis (HP:0000097)2.83441702
26Glomerulosclerosis (HP:0000096)2.80762533
27Abnormality of glutamine family amino acid metabolism (HP:0010902)2.67397518
28Abnormality of aromatic amino acid family metabolism (HP:0004338)2.67241273
29Steatorrhea (HP:0002570)2.66623088
30Bronchomalacia (HP:0002780)2.61748735
31Follicular hyperkeratosis (HP:0007502)2.58905546
32Xanthomatosis (HP:0000991)2.56916808
33Protrusio acetabuli (HP:0003179)2.53911834
34Malnutrition (HP:0004395)2.53061516
35Potter facies (HP:0002009)2.51819790
36Facial shape deformation (HP:0011334)2.51819790
37Intrahepatic cholestasis (HP:0001406)2.50802439
38Alopecia of scalp (HP:0002293)2.48711075
39Hyperactive renin-angiotensin system (HP:0000841)2.33693928
40Abnormality of the common coagulation pathway (HP:0010990)2.26611020
41Striae distensae (HP:0001065)2.24466252
42Respiratory distress (HP:0002098)2.18281062
43Hyperuricemia (HP:0002149)2.17381804
44Increased purine levels (HP:0004368)2.17381804
45Rectal prolapse (HP:0002035)2.15132143
46Hypercholesterolemia (HP:0003124)2.13040310
47Vertebral hypoplasia (HP:0008417)2.11116832
48Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.11116832
49Gout (HP:0001997)2.09610515
50Esophageal varix (HP:0002040)2.07794129
51Premature rupture of membranes (HP:0001788)2.07100904
52Hypolipoproteinemia (HP:0010981)2.05384401
53Exocrine pancreatic insufficiency (HP:0001738)2.05005403
54Tubulointerstitial abnormality (HP:0001969)1.97379948
55Tachypnea (HP:0002789)1.94679410
56Flat acetabular roof (HP:0003180)1.93488671
57Fibular aplasia (HP:0002990)1.92563539
58Skin nodule (HP:0200036)1.91300991
59Cerebral aneurysm (HP:0004944)1.89537356
60Abnormality of proline metabolism (HP:0010907)1.86988511
61Hydroxyprolinuria (HP:0003080)1.86988511
62Thyroid-stimulating hormone excess (HP:0002925)1.86484651
63Epidermoid cyst (HP:0200040)1.85865852
64Hemorrhage of the eye (HP:0011885)1.83478902
65Renal tubular acidosis (HP:0001947)1.83343524
66Hepatocellular carcinoma (HP:0001402)1.82532350
67Subacute progressive viral hepatitis (HP:0006572)1.81866271
68Abnormality of purine metabolism (HP:0004352)1.81770625
69Arthropathy (HP:0003040)1.79459358
70Neonatal death (HP:0003811)1.77629279
71Osteolytic defects of the phalanges of the hand (HP:0009771)1.76966463
72Osteolytic defects of the hand bones (HP:0009699)1.76966463
73Alveolar cell carcinoma (HP:0006519)1.76577292
74Recurrent gram-negative bacterial infections (HP:0005420)1.75219996
75Wormian bones (HP:0002645)1.74983446
76Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74385420
77Abnormality of the intrinsic pathway (HP:0010989)1.72496252
78Abnormality of carpal bone ossification (HP:0006257)1.70885460
79Broad face (HP:0000283)1.70151546
80Spontaneous abortion (HP:0005268)1.69778241
81Wide anterior fontanel (HP:0000260)1.68974695
82Bifid scrotum (HP:0000048)1.68605941
83Tubular atrophy (HP:0000092)1.67038625
84Abnormality of renal excretion (HP:0011036)1.66424298
85Mitral valve prolapse (HP:0001634)1.64244771
86Ventricular tachycardia (HP:0004756)1.63602006
87Hypoalphalipoproteinemia (HP:0003233)1.62298389
88Visceral angiomatosis (HP:0100761)1.61730562
89Menorrhagia (HP:0000132)1.61254004
90Alacrima (HP:0000522)1.60670497
91Hypothermia (HP:0002045)1.60436535
92Atrophic scars (HP:0001075)1.59897405
93Aneurysm (HP:0002617)1.58803754
94Neoplasm of the tracheobronchial system (HP:0100552)1.58721400
95Small epiphyses (HP:0010585)1.58354023
96Abnormal ossification of hand bones (HP:0005921)1.57964402
97Hoarse voice (HP:0001609)1.57569711
98Pigmentary retinal degeneration (HP:0001146)1.57396133
99Decreased lacrimation (HP:0000633)1.56693101
100Abnormality of chloride homeostasis (HP:0011422)1.55520699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.80942148
2MST1R4.03583988
3MAPK153.19749184
4STK392.97277216
5PDK22.95393387
6TIE12.92203235
7FGFR42.71271012
8EPHA32.68398377
9LMTK22.65833131
10MET2.45620986
11PIK3CA2.43856239
12RIPK12.27181502
13STK38L2.25710377
14FER2.22800810
15TGFBR22.22377294
16BRSK22.18672348
17MYLK2.08909412
18MST42.01757827
19AKT31.96411186
20FGFR31.80269210
21LATS11.61379735
22INSRR1.53496121
23NLK1.48400791
24PDGFRA1.35028195
25ERN11.32258799
26OXSR11.30266338
27MAPKAPK31.28651108
28NEK91.22844559
29EPHB11.21785314
30LATS21.21423947
31EPHB21.20631842
32STK241.18803525
33GRK11.15664082
34MAP3K31.11129608
35FGFR21.05396665
36DMPK1.03142440
37PTK20.98655068
38PDGFRB0.95032881
39MAP3K120.86037000
40ERBB40.81281513
41TTN0.81024072
42NTRK10.80483526
43LRRK20.79159810
44ACVR1B0.78557922
45BCR0.78502628
46IRAK10.76767593
47WNK40.76571119
48MAP3K70.76433015
49MAP3K140.75064264
50FGFR10.74339944
51ERBB20.71773277
52NEK60.71433199
53PRKAA20.70792397
54CDC42BPA0.69848455
55DDR20.69478497
56GSK3A0.67878923
57TRIB30.65207526
58PAK20.65183136
59YES10.64269365
60ROCK10.62282853
61JAK10.62069809
62PTK60.59573482
63STK30.55125648
64MAPKAPK50.54025553
65STK380.53481448
66BMPR1B0.51752118
67MELK0.49773104
68TRPM70.49752034
69IGF1R0.48483766
70TGFBR10.48219851
71PDPK10.48204589
72MTOR0.46816252
73WEE10.46104346
74MAP3K20.45999119
75ERBB30.45525182
76PRKD10.45523729
77PRKCE0.44689526
78PRKG20.44358262
79MAPK70.43630731
80PAK40.43572425
81TYK20.43368868
82CDK30.42455573
83BRSK10.40314190
84PAK30.39984376
85MKNK10.38091321
86CHUK0.37331893
87STK100.35380710
88PKN20.33156841
89MAPKAPK20.30937253
90RET0.30590590
91CDK120.28838196
92ICK0.27538561
93SGK2230.25995866
94SGK4940.25995866
95MAP2K10.25666527
96SIK10.25325888
97ABL20.24952162
98SGK20.24411014
99LIMK10.23639508
100PRKAA10.21535733

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.60453537
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.00320725
3Histidine metabolism_Homo sapiens_hsa003402.64272491
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29852239
5ECM-receptor interaction_Homo sapiens_hsa045122.28459442
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.28122291
7Arginine biosynthesis_Homo sapiens_hsa002202.03837818
8Retinol metabolism_Homo sapiens_hsa008301.98315276
9Steroid hormone biosynthesis_Homo sapiens_hsa001401.91707587
10Phenylalanine metabolism_Homo sapiens_hsa003601.89086329
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.84788323
12Fatty acid degradation_Homo sapiens_hsa000711.83518561
13Chemical carcinogenesis_Homo sapiens_hsa052041.81910813
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80212524
15Protein digestion and absorption_Homo sapiens_hsa049741.80195674
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79652597
17Bile secretion_Homo sapiens_hsa049761.71834283
18Fat digestion and absorption_Homo sapiens_hsa049751.66226698
19Mineral absorption_Homo sapiens_hsa049781.63917992
20Circadian rhythm_Homo sapiens_hsa047101.63255355
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59555179
22PPAR signaling pathway_Homo sapiens_hsa033201.57275626
23Staphylococcus aureus infection_Homo sapiens_hsa051501.55219399
24Starch and sucrose metabolism_Homo sapiens_hsa005001.52540189
25Adherens junction_Homo sapiens_hsa045201.41172866
26Tyrosine metabolism_Homo sapiens_hsa003501.40048611
27Arginine and proline metabolism_Homo sapiens_hsa003301.35065895
28Pertussis_Homo sapiens_hsa051331.31159199
29Tryptophan metabolism_Homo sapiens_hsa003801.27286526
30Caffeine metabolism_Homo sapiens_hsa002321.23649267
31Tight junction_Homo sapiens_hsa045301.22538856
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.18582049
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14278417
34Other glycan degradation_Homo sapiens_hsa005111.13807093
35Focal adhesion_Homo sapiens_hsa045101.12464653
36Prion diseases_Homo sapiens_hsa050201.11990175
37Vitamin digestion and absorption_Homo sapiens_hsa049771.10133580
38ABC transporters_Homo sapiens_hsa020101.06941853
39Pancreatic secretion_Homo sapiens_hsa049721.06331296
40Thyroid hormone synthesis_Homo sapiens_hsa049181.05978618
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.01288491
42Linoleic acid metabolism_Homo sapiens_hsa005911.00958387
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.00512219
44Nitrogen metabolism_Homo sapiens_hsa009100.99500815
45TGF-beta signaling pathway_Homo sapiens_hsa043500.95221288
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93894098
47Arachidonic acid metabolism_Homo sapiens_hsa005900.90314083
48Fatty acid biosynthesis_Homo sapiens_hsa000610.89668222
49Amoebiasis_Homo sapiens_hsa051460.86118147
50Renin-angiotensin system_Homo sapiens_hsa046140.85615559
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83078807
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.81138515
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81112424
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79147108
55Glycerolipid metabolism_Homo sapiens_hsa005610.77386373
56Hippo signaling pathway_Homo sapiens_hsa043900.75987551
57Proteoglycans in cancer_Homo sapiens_hsa052050.75699794
58beta-Alanine metabolism_Homo sapiens_hsa004100.74952890
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.74759885
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74227526
61Fatty acid metabolism_Homo sapiens_hsa012120.74082226
62Small cell lung cancer_Homo sapiens_hsa052220.73228553
63Sulfur metabolism_Homo sapiens_hsa009200.72937449
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72834979
65TNF signaling pathway_Homo sapiens_hsa046680.71003726
66Hepatitis C_Homo sapiens_hsa051600.69966541
67Insulin resistance_Homo sapiens_hsa049310.69457835
68Sphingolipid metabolism_Homo sapiens_hsa006000.66581559
69Ovarian steroidogenesis_Homo sapiens_hsa049130.65668500
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63969878
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62277211
72Galactose metabolism_Homo sapiens_hsa000520.62172285
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59098734
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57613693
75Ether lipid metabolism_Homo sapiens_hsa005650.56964082
76Fructose and mannose metabolism_Homo sapiens_hsa000510.54273050
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54136131
78Propanoate metabolism_Homo sapiens_hsa006400.52351346
79Basal cell carcinoma_Homo sapiens_hsa052170.51839395
80Dilated cardiomyopathy_Homo sapiens_hsa054140.51270754
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49191531
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48416187
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45594120
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44642885
85Glutathione metabolism_Homo sapiens_hsa004800.42675918
86FoxO signaling pathway_Homo sapiens_hsa040680.41489633
87Malaria_Homo sapiens_hsa051440.39593528
88Lysosome_Homo sapiens_hsa041420.37013482
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36458481
90Pyruvate metabolism_Homo sapiens_hsa006200.33873354
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31309327
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.29097118
93Vitamin B6 metabolism_Homo sapiens_hsa007500.29016339
94Steroid biosynthesis_Homo sapiens_hsa001000.28995643
95Glucagon signaling pathway_Homo sapiens_hsa049220.28966741
96Axon guidance_Homo sapiens_hsa043600.26873915
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26648664
98HIF-1 signaling pathway_Homo sapiens_hsa040660.26221390
99Bladder cancer_Homo sapiens_hsa052190.25995832
100Choline metabolism in cancer_Homo sapiens_hsa052310.24892542

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