C8ORF88

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.12651007
2CENP-A containing nucleosome assembly (GO:0034080)4.88715793
3chromatin remodeling at centromere (GO:0031055)4.77958697
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.65294643
5histone exchange (GO:0043486)4.38177554
6synapsis (GO:0007129)4.32427303
7kinetochore organization (GO:0051383)4.07093961
8DNA replication checkpoint (GO:0000076)3.98519547
9mitotic metaphase plate congression (GO:0007080)3.95919226
10ribosomal small subunit assembly (GO:0000028)3.94804324
11establishment of integrated proviral latency (GO:0075713)3.92442222
12oxidative phosphorylation (GO:0006119)3.89415965
13DNA replication-independent nucleosome organization (GO:0034724)3.86896843
14DNA replication-independent nucleosome assembly (GO:0006336)3.86896843
15ATP synthesis coupled proton transport (GO:0015986)3.79251142
16energy coupled proton transport, down electrochemical gradient (GO:0015985)3.79251142
17DNA strand elongation involved in DNA replication (GO:0006271)3.76197145
18kinetochore assembly (GO:0051382)3.73648306
19protein localization to kinetochore (GO:0034501)3.65260748
20DNA strand elongation (GO:0022616)3.61548038
21telomere maintenance via semi-conservative replication (GO:0032201)3.60737698
22purine nucleobase biosynthetic process (GO:0009113)3.54252106
23metaphase plate congression (GO:0051310)3.53859341
24negative regulation of mitotic sister chromatid separation (GO:2000816)3.50604979
25negative regulation of sister chromatid segregation (GO:0033046)3.50604979
26negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.50604979
27negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.50604979
28negative regulation of mitotic sister chromatid segregation (GO:0033048)3.50604979
29negative regulation of chromosome segregation (GO:0051985)3.46197889
30spindle checkpoint (GO:0031577)3.45847119
31protein localization to chromosome, centromeric region (GO:0071459)3.38838102
32regulation of mitochondrial translation (GO:0070129)3.38818539
33maturation of SSU-rRNA (GO:0030490)3.38635431
34protein neddylation (GO:0045116)3.36843791
35mitotic sister chromatid segregation (GO:0000070)3.35830480
36mitotic spindle checkpoint (GO:0071174)3.35130054
37chromosome organization involved in meiosis (GO:0070192)3.33481604
38mitotic spindle assembly checkpoint (GO:0007094)3.31622402
39DNA replication-dependent nucleosome organization (GO:0034723)3.31379896
40DNA replication-dependent nucleosome assembly (GO:0006335)3.31379896
41ventricular cardiac muscle cell development (GO:0055015)3.29864736
42spindle assembly checkpoint (GO:0071173)3.28087015
43establishment of protein localization to mitochondrial membrane (GO:0090151)3.26258807
44DNA ligation (GO:0006266)3.26101680
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23884123
46mitotic recombination (GO:0006312)3.22698950
47rRNA modification (GO:0000154)3.22523691
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21391169
49telomere maintenance via recombination (GO:0000722)3.21185050
50regulation of mitotic metaphase/anaphase transition (GO:0030071)3.20160079
51regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.20160079
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19745715
53chaperone-mediated protein transport (GO:0072321)3.18794488
54regulation of sister chromatid segregation (GO:0033045)3.18194258
55regulation of mitotic sister chromatid separation (GO:0010965)3.18194258
56regulation of mitotic sister chromatid segregation (GO:0033047)3.18194258
57regulation of chromosome segregation (GO:0051983)3.18060797
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.16922715
59sister chromatid segregation (GO:0000819)3.16008430
60ribosomal large subunit biogenesis (GO:0042273)3.15541861
61establishment of viral latency (GO:0019043)3.14056075
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.13478265
63translational termination (GO:0006415)3.10644616
64IMP biosynthetic process (GO:0006188)3.06454725
65viral transcription (GO:0019083)3.06097738
66nucleobase biosynthetic process (GO:0046112)3.05420812
67viral mRNA export from host cell nucleus (GO:0046784)3.02233180
68deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.02171456
69DNA synthesis involved in DNA repair (GO:0000731)3.00993923
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.98681663
71pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.97759346
72transcription elongation from RNA polymerase III promoter (GO:0006385)2.96522814
73termination of RNA polymerase III transcription (GO:0006386)2.96522814
74mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.94556146
75mitotic nuclear envelope disassembly (GO:0007077)2.93738227
76respiratory electron transport chain (GO:0022904)2.93432725
77male meiosis I (GO:0007141)2.93018977
78inner mitochondrial membrane organization (GO:0007007)2.92777363
79negative regulation of ligase activity (GO:0051352)2.92278810
80negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92278810
81meiosis I (GO:0007127)2.91900976
82nuclear pore complex assembly (GO:0051292)2.91057056
83regulation of helicase activity (GO:0051095)2.90945640
84establishment of chromosome localization (GO:0051303)2.90169555
85SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.89259415
86resolution of meiotic recombination intermediates (GO:0000712)2.88887900
87mitotic chromosome condensation (GO:0007076)2.88684911
88DNA replication initiation (GO:0006270)2.88227745
89formation of translation preinitiation complex (GO:0001731)2.85910380
90cotranslational protein targeting to membrane (GO:0006613)2.84660662
91ribosomal small subunit biogenesis (GO:0042274)2.83772732
92electron transport chain (GO:0022900)2.83407810
93protein complex biogenesis (GO:0070271)2.81930467
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81886973
95ATP-dependent chromatin remodeling (GO:0043044)2.81672334
96mitochondrial respiratory chain complex assembly (GO:0033108)2.81097052
97chromosome segregation (GO:0007059)2.80318991
98telomere maintenance via telomere lengthening (GO:0010833)2.80180131
99DNA unwinding involved in DNA replication (GO:0006268)2.79908343
100reciprocal DNA recombination (GO:0035825)2.79284350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.96314610
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.57194571
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.28460671
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.08130578
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.85480058
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.40030156
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.39302249
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.38529438
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.26503027
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.02091226
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.91753518
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.83882051
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81785109
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.75773096
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64830169
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63625636
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62649738
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57618669
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54601471
20ELK1_19687146_ChIP-ChIP_HELA_Human2.48874863
21AR_21909140_ChIP-Seq_LNCAP_Human2.40351625
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39074826
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.37210548
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35316747
25VDR_23849224_ChIP-Seq_CD4+_Human2.21895388
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21243777
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18119641
28DCP1A_22483619_ChIP-Seq_HELA_Human2.16961333
29TTF2_22483619_ChIP-Seq_HELA_Human2.13597625
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11957845
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09698405
32FOXP3_21729870_ChIP-Seq_TREG_Human2.03317688
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.93387648
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92752592
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91348706
36XRN2_22483619_ChIP-Seq_HELA_Human1.91173703
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87819630
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.83491528
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82378535
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81274012
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79090992
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77909812
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.76696225
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.71977760
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71019993
46GABP_19822575_ChIP-Seq_HepG2_Human1.66494065
47EWS_26573619_Chip-Seq_HEK293_Human1.64530309
48MYC_18940864_ChIP-ChIP_HL60_Human1.62594204
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58024258
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55197830
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52181151
52FUS_26573619_Chip-Seq_HEK293_Human1.49045262
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.48107046
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44379298
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43698931
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43439826
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35384864
58NANOG_16153702_ChIP-ChIP_HESCs_Human1.35229812
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.34319520
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34314365
61SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.24641606
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.15139197
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15067122
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14741579
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14243909
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12416028
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11075832
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07649123
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05255502
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04954491
71VDR_22108803_ChIP-Seq_LS180_Human1.04191631
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.03919872
73KDM5A_27292631_Chip-Seq_BREAST_Human0.99015368
74SOX17_20123909_ChIP-Seq_XEN_Mouse0.99006580
75POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97789334
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96346671
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96161596
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95143888
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94864119
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94178911
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91250346
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90275320
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86064499
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84393968
85SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81899632
86TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80360492
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79890225
88TFEB_21752829_ChIP-Seq_HELA_Human0.79293848
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79252824
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77597807
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77373581
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76930404
93IRF1_19129219_ChIP-ChIP_H3396_Human0.76101482
94NANOG_21062744_ChIP-ChIP_HESCs_Human0.72005806
95NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71450690
96TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71220673
97KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.67553037
98KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.67553037
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.67553037
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.67156395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.16359927
2MP0010094_abnormal_chromosome_stability3.77208935
3MP0004957_abnormal_blastocyst_morpholog3.71118177
4MP0003111_abnormal_nucleus_morphology3.63590028
5MP0003693_abnormal_embryo_hatching3.21812436
6MP0003077_abnormal_cell_cycle2.90954851
7MP0008932_abnormal_embryonic_tissue2.82540719
8MP0009697_abnormal_copulation2.52154140
9MP0008007_abnormal_cellular_replicative2.30054774
10MP0002938_white_spotting2.28982822
11MP0008877_abnormal_DNA_methylation2.22499027
12MP0003136_yellow_coat_color2.21414785
13MP0008057_abnormal_DNA_replication2.16115156
14MP0002837_dystrophic_cardiac_calcinosis2.01602848
15MP0004147_increased_porphyrin_level2.01160351
16MP0003718_maternal_effect1.90196190
17MP0003186_abnormal_redox_activity1.86681959
18MP0003941_abnormal_skin_development1.80107024
19MP0000372_irregular_coat_pigmentation1.78307278
20MP0006035_abnormal_mitochondrial_morpho1.68370215
21MP0004215_abnormal_myocardial_fiber1.66071495
22MP0010307_abnormal_tumor_latency1.64175175
23MP0001661_extended_life_span1.62892191
24MP0006036_abnormal_mitochondrial_physio1.62221327
25MP0002102_abnormal_ear_morphology1.61299612
26MP0003786_premature_aging1.60283566
27MP0009379_abnormal_foot_pigmentation1.54885344
28MP0002210_abnormal_sex_determination1.53176301
29MP0003806_abnormal_nucleotide_metabolis1.52644644
30MP0003567_abnormal_fetal_cardiomyocyte1.51449130
31MP0000350_abnormal_cell_proliferation1.51136928
32MP0001929_abnormal_gametogenesis1.47978436
33MP0006292_abnormal_olfactory_placode1.45833627
34MP0003646_muscle_fatigue1.42684241
35MP0001730_embryonic_growth_arrest1.40836872
36MP0001697_abnormal_embryo_size1.39332934
37MP0001145_abnormal_male_reproductive1.36944456
38MP0001293_anophthalmia1.35900216
39MP0004084_abnormal_cardiac_muscle1.35464649
40MP0003937_abnormal_limbs/digits/tail_de1.34947098
41MP0002085_abnormal_embryonic_tissue1.32641122
42MP0000653_abnormal_sex_gland1.30142530
43MP0001672_abnormal_embryogenesis/_devel1.27964849
44MP0005380_embryogenesis_phenotype1.27964849
45MP0002160_abnormal_reproductive_system1.26359324
46MP0001529_abnormal_vocalization1.26087937
47MP0005408_hypopigmentation1.25822389
48MP0010030_abnormal_orbit_morphology1.22657679
49MP0001188_hyperpigmentation1.20295070
50MP0002084_abnormal_developmental_patter1.18081477
51MP0003698_abnormal_male_reproductive1.17526963
52MP0005171_absent_coat_pigmentation1.12196381
53MP0000313_abnormal_cell_death1.11640992
54MP0002163_abnormal_gland_morphology1.10507989
55MP0002080_prenatal_lethality1.08872511
56MP0003984_embryonic_growth_retardation1.08394359
57MP0008995_early_reproductive_senescence1.07213939
58MP0005187_abnormal_penis_morphology1.06200710
59MP0002088_abnormal_embryonic_growth/wei1.04722681
60MP0005670_abnormal_white_adipose1.04179438
61MP0002234_abnormal_pharynx_morphology1.02782668
62MP0003119_abnormal_digestive_system0.99392029
63MP0005389_reproductive_system_phenotype0.97641057
64MP0005503_abnormal_tendon_morphology0.96470034
65MP0009250_abnormal_appendicular_skeleto0.96462051
66MP0006072_abnormal_retinal_apoptosis0.95439112
67MP0001119_abnormal_female_reproductive0.94607140
68MP0003011_delayed_dark_adaptation0.93914190
69MP0005623_abnormal_meninges_morphology0.92833193
70MP0000049_abnormal_middle_ear0.91381870
71MP0000358_abnormal_cell_content/0.90824875
72MP0001727_abnormal_embryo_implantation0.90410269
73MP0005330_cardiomyopathy0.90406384
74MP0004036_abnormal_muscle_relaxation0.90301700
75MP0000749_muscle_degeneration0.90270090
76MP0001286_abnormal_eye_development0.87545368
77MP0003137_abnormal_impulse_conducting0.87025999
78MP0003385_abnormal_body_wall0.86011392
79MP0004272_abnormal_basement_membrane0.84829102
80MP0000631_abnormal_neuroendocrine_gland0.84516995
81MP0005410_abnormal_fertilization0.84425911
82MP0002095_abnormal_skin_pigmentation0.83537717
83MP0008775_abnormal_heart_ventricle0.83263412
84MP0002697_abnormal_eye_size0.82170975
85MP0010352_gastrointestinal_tract_polyps0.80188086
86MP0003890_abnormal_embryonic-extraembry0.79315560
87MP0008789_abnormal_olfactory_epithelium0.78190197
88MP0003950_abnormal_plasma_membrane0.78141399
89MP0000678_abnormal_parathyroid_gland0.77534967
90MP0005397_hematopoietic_system_phenotyp0.76287192
91MP0001545_abnormal_hematopoietic_system0.76287192
92MP0005075_abnormal_melanosome_morpholog0.76177687
93MP0000516_abnormal_urinary_system0.75444628
94MP0005367_renal/urinary_system_phenotyp0.75444628
95MP0009672_abnormal_birth_weight0.75133799
96MP0002090_abnormal_vision0.74419305
97MP0002086_abnormal_extraembryonic_tissu0.73394655
98MP0008438_abnormal_cutaneous_collagen0.72214084
99MP0002161_abnormal_fertility/fecundity0.71337727
100MP0003935_abnormal_craniofacial_develop0.69001527

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.77465848
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.53560052
3Acute necrotizing encephalopathy (HP:0006965)3.53346710
4Abnormal mitochondria in muscle tissue (HP:0008316)3.43435469
5Degeneration of anterior horn cells (HP:0002398)3.43293750
6Abnormality of the anterior horn cell (HP:0006802)3.43293750
7Acute encephalopathy (HP:0006846)3.38845271
8Increased hepatocellular lipid droplets (HP:0006565)3.30763482
9Reticulocytopenia (HP:0001896)3.29354445
10Abnormal number of erythroid precursors (HP:0012131)3.18762161
11Mitochondrial inheritance (HP:0001427)3.15065414
12Colon cancer (HP:0003003)3.14723848
13Birth length less than 3rd percentile (HP:0003561)3.12195950
14Progressive macrocephaly (HP:0004481)3.08866563
15Abnormality of cells of the erythroid lineage (HP:0012130)3.03689938
16Increased CSF lactate (HP:0002490)3.02373504
17Lipid accumulation in hepatocytes (HP:0006561)2.94822508
18Hepatocellular necrosis (HP:0001404)2.93427510
19Abnormality of chromosome stability (HP:0003220)2.92588613
20Meckel diverticulum (HP:0002245)2.87150117
21Decreased activity of mitochondrial respiratory chain (HP:0008972)2.77200826
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.77200826
23Hepatic necrosis (HP:0002605)2.71770045
24Abnormality of the ileum (HP:0001549)2.70185302
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.68410730
26Type I transferrin isoform profile (HP:0003642)2.63768566
27Macrocytic anemia (HP:0001972)2.62553692
28Duodenal stenosis (HP:0100867)2.59476488
29Small intestinal stenosis (HP:0012848)2.59476488
30Increased intramyocellular lipid droplets (HP:0012240)2.57526399
31Short middle phalanx of the 5th finger (HP:0004220)2.47988007
32Increased serum pyruvate (HP:0003542)2.46279194
33Renal Fanconi syndrome (HP:0001994)2.46036806
34Abnormality of the preputium (HP:0100587)2.44645807
35Abnormal lung lobation (HP:0002101)2.41656347
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41429445
37Pallor (HP:0000980)2.41007557
38Cerebral edema (HP:0002181)2.34725098
39Triphalangeal thumb (HP:0001199)2.32170285
40Abnormal umbilical cord blood vessels (HP:0011403)2.31911176
41Single umbilical artery (HP:0001195)2.31911176
42Abnormality of the fetal cardiovascular system (HP:0010948)2.31911176
43Neoplasm of the colon (HP:0100273)2.24662184
44Abnormality of the heme biosynthetic pathway (HP:0010472)2.23857529
45Abnormality of the labia minora (HP:0012880)2.23224158
46Abnormality of the duodenum (HP:0002246)2.20370847
47Exertional dyspnea (HP:0002875)2.20115393
48Nephroblastoma (Wilms tumor) (HP:0002667)2.20070619
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18860320
50Abnormal protein N-linked glycosylation (HP:0012347)2.18860320
51Abnormal protein glycosylation (HP:0012346)2.18860320
52Abnormal glycosylation (HP:0012345)2.18860320
53Lactic acidosis (HP:0003128)2.18697596
54Increased serum lactate (HP:0002151)2.18671405
55Pancreatic fibrosis (HP:0100732)2.18062002
56Embryonal renal neoplasm (HP:0011794)2.17634529
57Myelodysplasia (HP:0002863)2.14216079
58Abnormality of glycolysis (HP:0004366)2.13481324
59Microvesicular hepatic steatosis (HP:0001414)2.06888589
60Respiratory failure (HP:0002878)2.04784580
61Increased muscle lipid content (HP:0009058)2.01853782
62Respiratory difficulties (HP:0002880)2.01644619
63Short tibia (HP:0005736)1.99016567
64Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.98814466
65Sloping forehead (HP:0000340)1.98340945
66Hyperglycinemia (HP:0002154)1.98332172
67Bifid tongue (HP:0010297)1.97816589
68Exercise intolerance (HP:0003546)1.97547480
69Absent thumb (HP:0009777)1.94788015
70Medulloblastoma (HP:0002885)1.94353512
71Hypoplastic left heart (HP:0004383)1.92680456
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88208719
73Median cleft lip (HP:0000161)1.86508411
74Abnormality of methionine metabolism (HP:0010901)1.85719274
75Abnormality of serum amino acid levels (HP:0003112)1.83384613
76Rhabdomyosarcoma (HP:0002859)1.79482447
77Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.78184928
78Increased nuchal translucency (HP:0010880)1.77892803
79Reduced antithrombin III activity (HP:0001976)1.76946813
80Abnormality of the umbilical cord (HP:0010881)1.76914276
81Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.76800912
82Pancreatic islet-cell hyperplasia (HP:0004510)1.76384969
83Ectopic kidney (HP:0000086)1.73990971
84Neoplasm of the small intestine (HP:0100833)1.73327105
85Abnormality of abdominal situs (HP:0011620)1.73156328
86Abdominal situs inversus (HP:0003363)1.73156328
87Abnormality of the carotid arteries (HP:0005344)1.71335723
88Cortical dysplasia (HP:0002539)1.71309894
89Long nose (HP:0003189)1.69702434
90Ovarian neoplasm (HP:0100615)1.69170302
91Aplasia/Hypoplasia of the tibia (HP:0005772)1.68347596
92Volvulus (HP:0002580)1.67592392
93Hypoglycemic seizures (HP:0002173)1.64852074
94Cerebral hypomyelination (HP:0006808)1.64367425
95Neoplasm of the rectum (HP:0100743)1.63460576
96Abnormality of aspartate family amino acid metabolism (HP:0010899)1.63245472
97Aplastic anemia (HP:0001915)1.62121635
98Duplication of thumb phalanx (HP:0009942)1.61308177
99Methylmalonic acidemia (HP:0002912)1.60820635
100Postnatal microcephaly (HP:0005484)1.60788221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.84550750
2PBK4.00763111
3CDC73.11883782
4TTK3.09896112
5VRK22.92149305
6PLK42.86845254
7ZAK2.77965898
8TAF12.73992745
9NEK12.59821116
10WEE12.53960651
11VRK12.50079712
12PLK32.45511098
13EIF2AK12.44241194
14EIF2AK32.03037776
15SRPK12.02924380
16STK161.96629844
17PLK11.95449369
18TNIK1.93825953
19CCNB11.89623210
20NME21.86760358
21BRSK21.80297673
22MKNK11.75780247
23MKNK21.69128996
24NUAK11.63396823
25NEK21.48204535
26CHEK21.47457849
27TSSK61.30473901
28MYLK1.28256733
29AURKB1.26152550
30STK41.25043586
31TRIM281.22834785
32ATR1.21287649
33BRSK11.17712464
34TLK11.16721611
35AURKA1.12170257
36NME11.11782118
37MST41.11659139
38DYRK31.05870270
39PNCK1.03602523
40STK30.98677600
41PASK0.97680800
42BMPR1B0.96157519
43DMPK0.93289750
44RPS6KA50.92931190
45SCYL20.90358400
46ATM0.87388306
47PLK20.86857597
48KDR0.86808075
49NTRK10.84811346
50STK38L0.82728283
51WNK30.79450614
52CHEK10.77096242
53FLT30.76375447
54MAP3K120.74972260
55CDK190.74395948
56PDK20.72635952
57CDK70.70113960
58MAP3K80.69759432
59BRAF0.68817306
60RAF10.66237011
61CSNK2A10.60314551
62EIF2AK20.57005396
63CSNK1G10.56900669
64CDK80.56556421
65CLK10.56036220
66CDK30.55913390
67CSNK2A20.53992078
68ACVR1B0.52693202
69CDK10.51532486
70DYRK20.51274057
71DAPK30.50115750
72ERBB40.48260908
73BCR0.48234727
74CSNK1G30.47122860
75CDK20.46509190
76BCKDK0.44613490
77AKT20.43678458
78ILK0.41941979
79RPS6KB20.39971800
80MARK30.38719354
81FRK0.37812040
82NLK0.37348975
83CSNK1G20.31021290
84MAPKAPK50.30210539
85PRKDC0.30106874
86MAP3K40.29337762
87PIM20.29226975
88STK240.28378381
89RPS6KA40.27989360
90PIM10.27732848
91INSRR0.27009013
92MUSK0.26634143
93LATS10.26421343
94PAK10.25858004
95PAK20.25814520
96CSNK1E0.25377145
97PIK3CG0.25273509
98LIMK10.24741552
99ABL20.24550664
100CDK40.23199127

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.87130795
2Mismatch repair_Homo sapiens_hsa034303.72324207
3Ribosome_Homo sapiens_hsa030103.58953694
4Proteasome_Homo sapiens_hsa030503.25909662
5Homologous recombination_Homo sapiens_hsa034403.17612300
6Parkinsons disease_Homo sapiens_hsa050122.82187140
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.78887227
8Oxidative phosphorylation_Homo sapiens_hsa001902.76968210
9Non-homologous end-joining_Homo sapiens_hsa034502.75741785
10RNA polymerase_Homo sapiens_hsa030202.64758206
11Spliceosome_Homo sapiens_hsa030402.35973005
12Base excision repair_Homo sapiens_hsa034102.34277252
13Fanconi anemia pathway_Homo sapiens_hsa034602.26090616
14RNA transport_Homo sapiens_hsa030132.25990113
15Cell cycle_Homo sapiens_hsa041102.24741949
16Nucleotide excision repair_Homo sapiens_hsa034202.21637779
17One carbon pool by folate_Homo sapiens_hsa006702.18131839
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16377227
19Huntingtons disease_Homo sapiens_hsa050162.11307490
20Protein export_Homo sapiens_hsa030602.08803384
21Pyrimidine metabolism_Homo sapiens_hsa002401.86452303
22Basal transcription factors_Homo sapiens_hsa030221.81035153
23RNA degradation_Homo sapiens_hsa030181.77088565
24Sulfur relay system_Homo sapiens_hsa041221.71422305
25Alzheimers disease_Homo sapiens_hsa050101.68407924
26Fatty acid elongation_Homo sapiens_hsa000621.67463690
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55453169
28Propanoate metabolism_Homo sapiens_hsa006401.52919793
29Pyruvate metabolism_Homo sapiens_hsa006201.51810597
30Purine metabolism_Homo sapiens_hsa002301.47776244
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44817989
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43820634
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.39633929
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29165020
35Oocyte meiosis_Homo sapiens_hsa041141.25959546
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23493417
37Cardiac muscle contraction_Homo sapiens_hsa042601.15973660
38Folate biosynthesis_Homo sapiens_hsa007901.14584696
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08356984
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05269824
41Systemic lupus erythematosus_Homo sapiens_hsa053221.02152217
42p53 signaling pathway_Homo sapiens_hsa041151.01679510
43Glutathione metabolism_Homo sapiens_hsa004800.98145440
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97837073
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97626723
46mRNA surveillance pathway_Homo sapiens_hsa030150.95842397
47Selenocompound metabolism_Homo sapiens_hsa004500.94106595
48Biosynthesis of amino acids_Homo sapiens_hsa012300.85321302
49Carbon metabolism_Homo sapiens_hsa012000.85129297
50Alcoholism_Homo sapiens_hsa050340.83777755
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82907192
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79730783
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72281431
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69676569
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68593483
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68022629
57Metabolic pathways_Homo sapiens_hsa011000.66789840
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65516460
59Vitamin B6 metabolism_Homo sapiens_hsa007500.64317557
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64239186
61TGF-beta signaling pathway_Homo sapiens_hsa043500.54734847
62N-Glycan biosynthesis_Homo sapiens_hsa005100.53973578
63Steroid biosynthesis_Homo sapiens_hsa001000.51133385
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46501252
65Basal cell carcinoma_Homo sapiens_hsa052170.45024154
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43562485
67Fatty acid metabolism_Homo sapiens_hsa012120.43517582
68Arginine and proline metabolism_Homo sapiens_hsa003300.33582016
69Viral carcinogenesis_Homo sapiens_hsa052030.33225383
70Butanoate metabolism_Homo sapiens_hsa006500.31945623
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29468830
72Wnt signaling pathway_Homo sapiens_hsa043100.28722538
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26768176
74Pentose phosphate pathway_Homo sapiens_hsa000300.26128661
75Peroxisome_Homo sapiens_hsa041460.25529082
76Olfactory transduction_Homo sapiens_hsa047400.23646546
77Epstein-Barr virus infection_Homo sapiens_hsa051690.23024277
78Lysine degradation_Homo sapiens_hsa003100.22842471
79Fatty acid degradation_Homo sapiens_hsa000710.21398415
80Hedgehog signaling pathway_Homo sapiens_hsa043400.20515948
81Hippo signaling pathway_Homo sapiens_hsa043900.20240767
82Phototransduction_Homo sapiens_hsa047440.18269601
83Melanoma_Homo sapiens_hsa052180.16760191
84beta-Alanine metabolism_Homo sapiens_hsa004100.14104398
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13688222
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.10421972
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09570029
88Small cell lung cancer_Homo sapiens_hsa052220.09496188
89Regulation of autophagy_Homo sapiens_hsa041400.08487551
90Tryptophan metabolism_Homo sapiens_hsa003800.08169784
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.06367498
92HTLV-I infection_Homo sapiens_hsa051660.05399795
93Thyroid cancer_Homo sapiens_hsa052160.04162381
94ECM-receptor interaction_Homo sapiens_hsa045120.04107183
95Adherens junction_Homo sapiens_hsa045200.03263172
96MicroRNAs in cancer_Homo sapiens_hsa052060.02582898
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.02028067
98Sulfur metabolism_Homo sapiens_hsa009200.01914956
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.01655526
100Colorectal cancer_Homo sapiens_hsa052100.00330615

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