C9ORF114

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.61219429
2peptidyl-arginine omega-N-methylation (GO:0035247)5.26438973
3viral transcription (GO:0019083)4.99616617
4histone arginine methylation (GO:0034969)4.81918431
5rRNA transcription (GO:0009303)4.76222570
6translational termination (GO:0006415)4.67341299
7amyloid precursor protein catabolic process (GO:0042987)4.45766586
8maturation of SSU-rRNA (GO:0030490)4.41378320
9deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.38048414
10translational elongation (GO:0006414)4.34066112
11regulation of translational fidelity (GO:0006450)4.27416502
12peptidyl-arginine methylation (GO:0018216)4.27043180
13peptidyl-arginine N-methylation (GO:0035246)4.27043180
14L-serine metabolic process (GO:0006563)4.12735187
15pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.08093591
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.98663799
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.92699272
18DNA replication checkpoint (GO:0000076)3.84856580
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.83438459
20pentose metabolic process (GO:0019321)3.83367237
21viral life cycle (GO:0019058)3.78654398
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.75349135
23ATP synthesis coupled proton transport (GO:0015986)3.75349135
24protein targeting to ER (GO:0045047)3.74835602
25GDP-mannose metabolic process (GO:0019673)3.74022627
26oxidative phosphorylation (GO:0006119)3.73163002
27DNA strand elongation involved in DNA replication (GO:0006271)3.72785655
28cotranslational protein targeting to membrane (GO:0006613)3.72490473
29regulation of mitochondrial translation (GO:0070129)3.70370703
30heterochromatin organization (GO:0070828)3.68752311
31ribonucleoprotein complex biogenesis (GO:0022613)3.67502834
32formation of translation preinitiation complex (GO:0001731)3.61934509
33DNA strand elongation (GO:0022616)3.61630690
34translational initiation (GO:0006413)3.60505897
35cellular protein complex disassembly (GO:0043624)3.57838807
36DNA replication initiation (GO:0006270)3.56882199
37establishment of protein localization to endoplasmic reticulum (GO:0072599)3.53467714
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.52566737
39muscle cell fate commitment (GO:0042693)3.52310580
40regulation of mammary gland epithelial cell proliferation (GO:0033599)3.51642908
41ribosomal small subunit assembly (GO:0000028)3.48820247
42protein localization to endoplasmic reticulum (GO:0070972)3.48005878
43proline biosynthetic process (GO:0006561)3.47408843
44protein complex disassembly (GO:0043241)3.45901598
45rRNA modification (GO:0000154)3.45589993
46ribosome biogenesis (GO:0042254)3.32706438
47DNA strand renaturation (GO:0000733)3.32298791
48UTP biosynthetic process (GO:0006228)3.30207930
49pyrimidine nucleotide catabolic process (GO:0006244)3.29043340
50pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.27230060
51telomere maintenance via semi-conservative replication (GO:0032201)3.26535443
52cellular component biogenesis (GO:0044085)3.25953329
53DNA unwinding involved in DNA replication (GO:0006268)3.24354042
54pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.21047790
55macromolecular complex disassembly (GO:0032984)3.20037615
56iron-sulfur cluster assembly (GO:0016226)3.16391451
57metallo-sulfur cluster assembly (GO:0031163)3.16391451
58base-excision repair, AP site formation (GO:0006285)3.15043355
59peptidyl-histidine modification (GO:0018202)3.15005076
60ribosomal large subunit biogenesis (GO:0042273)3.13957125
61rRNA methylation (GO:0031167)3.12213037
62rRNA processing (GO:0006364)3.09774630
63amyloid precursor protein metabolic process (GO:0042982)3.08075959
64translation (GO:0006412)3.07010050
65pseudouridine synthesis (GO:0001522)3.05050245
66guanosine-containing compound biosynthetic process (GO:1901070)3.04396256
67protein targeting to mitochondrion (GO:0006626)3.03983010
68apoptotic process involved in morphogenesis (GO:0060561)3.03114438
69spliceosomal snRNP assembly (GO:0000387)3.02599906
70chaperone-mediated protein transport (GO:0072321)3.00524880
71spliceosomal tri-snRNP complex assembly (GO:0000244)2.99293255
72folic acid metabolic process (GO:0046655)2.98958103
73muscle organ morphogenesis (GO:0048644)2.98572888
74kinetochore assembly (GO:0051382)2.98530261
75establishment of protein localization to mitochondrion (GO:0072655)2.96699196
76pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.95022836
77regulation of chromatin binding (GO:0035561)2.93928923
78serine family amino acid biosynthetic process (GO:0009070)2.93653639
79ribonucleoside triphosphate biosynthetic process (GO:0009201)2.93358230
80protein insertion into membrane (GO:0051205)2.92843583
81pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.91376708
82pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.91271380
83rRNA metabolic process (GO:0016072)2.89950479
84outer ear morphogenesis (GO:0042473)2.89938383
85base-excision repair (GO:0006284)2.89643746
86pentose-phosphate shunt (GO:0006098)2.88493247
87protein-DNA complex disassembly (GO:0032986)2.88199782
88nucleosome disassembly (GO:0006337)2.88199782
89tooth mineralization (GO:0034505)2.87462149
90mitochondrial respiratory chain complex assembly (GO:0033108)2.86029977
91protein complex biogenesis (GO:0070271)2.85723013
92CTP biosynthetic process (GO:0006241)2.85375321
93CTP metabolic process (GO:0046036)2.85375321
94nucleobase biosynthetic process (GO:0046112)2.85099979
95regulation of translational elongation (GO:0006448)2.83109067
96protein maturation by protein folding (GO:0022417)2.83015480
97UTP metabolic process (GO:0046051)2.81337105
98mitotic G1 DNA damage checkpoint (GO:0031571)2.80619790
99deoxyribonucleotide catabolic process (GO:0009264)2.77767753
100ATP biosynthetic process (GO:0006754)2.77313679

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.38875082
2E2F7_22180533_ChIP-Seq_HELA_Human3.25495092
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15086944
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.02146950
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65647322
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53887048
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52687998
8XRN2_22483619_ChIP-Seq_HELA_Human2.42874024
9VDR_21846776_ChIP-Seq_THP-1_Human2.36710126
10MYC_22102868_ChIP-Seq_BL_Human2.33613080
11THAP11_20581084_ChIP-Seq_MESCs_Mouse2.30548980
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24968857
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20418261
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10010508
15LXR_22292898_ChIP-Seq_THP-1_Human2.09666801
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.08401196
17CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.00034382
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99739239
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93733896
20ZNF263_19887448_ChIP-Seq_K562_Human1.91346344
21TET1_21451524_ChIP-Seq_MESCs_Mouse1.89933057
22DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.86286100
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79666115
24FOXM1_23109430_ChIP-Seq_U2OS_Human1.76585163
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75137575
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70468004
27GABP_19822575_ChIP-Seq_HepG2_Human1.69552271
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.61830839
29P68_20966046_ChIP-Seq_HELA_Human1.60742617
30DCP1A_22483619_ChIP-Seq_HELA_Human1.60575383
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.59959960
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59875679
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58350699
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57001774
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56831590
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55196260
37RACK7_27058665_Chip-Seq_MCF-7_Human1.54000777
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48657787
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48238783
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.47689176
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47561206
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46473277
43CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44307471
44TTF2_22483619_ChIP-Seq_HELA_Human1.44295698
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43799464
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42016442
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40844028
48DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.40258897
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40200683
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38910343
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38079877
52KDM5A_27292631_Chip-Seq_BREAST_Human1.37784867
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37361661
54FOXP1_21924763_ChIP-Seq_HESCs_Human1.34642070
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33229666
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.32004222
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.31369867
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31233983
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.31089782
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29472295
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28841418
62CTCF_18555785_ChIP-Seq_MESCs_Mouse1.27960138
63MAF_26560356_Chip-Seq_TH2_Human1.27204520
64CIITA_25753668_ChIP-Seq_RAJI_Human1.27199755
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26324096
66FOXP3_21729870_ChIP-Seq_TREG_Human1.25968984
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25874057
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25778398
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23583781
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23105997
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.22908482
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21436089
73KDM2B_26808549_Chip-Seq_DND41_Human1.21371646
74CTCF_26484167_Chip-Seq_Bcells_Mouse1.18766506
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18654389
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18562455
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18424648
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17534528
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17229984
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.16405099
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16051983
82SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15425117
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14082139
84BCOR_27268052_Chip-Seq_Bcells_Human1.13757275
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13565835
86BCL6_27268052_Chip-Seq_Bcells_Human1.13305076
87SMC4_20622854_ChIP-Seq_HELA_Human1.13218034
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13202074
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12158273
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11278150
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10898992
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10499881
93RARA_24833708_ChIP-Seq_LIVER_Mouse1.09295622
94E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09266039
95TCF7_22412390_ChIP-Seq_EML_Mouse1.05326009
96MAF_26560356_Chip-Seq_TH1_Human1.04868730
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04457556
98PHF8_20622854_ChIP-Seq_HELA_Human1.04430476
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04419325
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04126386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.19372647
2MP0000678_abnormal_parathyroid_gland3.72812313
3MP0010030_abnormal_orbit_morphology3.54570370
4MP0003111_abnormal_nucleus_morphology3.53405710
5MP0004957_abnormal_blastocyst_morpholog3.47268395
6MP0010094_abnormal_chromosome_stability3.02089196
7MP0009333_abnormal_splenocyte_physiolog2.84839089
8MP0002249_abnormal_larynx_morphology2.83189924
9MP0008932_abnormal_embryonic_tissue2.77605733
10MP0003077_abnormal_cell_cycle2.45011684
11MP0004185_abnormal_adipocyte_glucose2.42971295
12MP0008058_abnormal_DNA_repair2.29872031
13MP0008007_abnormal_cellular_replicative2.22328774
14MP0000049_abnormal_middle_ear2.04474064
15MP0003136_yellow_coat_color1.98563009
16MP0001730_embryonic_growth_arrest1.94969905
17MP0002254_reproductive_system_inflammat1.90429679
18MP0008260_abnormal_autophagy1.90380315
19MP0002234_abnormal_pharynx_morphology1.88432025
20MP0005451_abnormal_body_composition1.88317748
21MP0003786_premature_aging1.83740424
22MP0005501_abnormal_skin_physiology1.78572219
23MP0003123_paternal_imprinting1.75944920
24MP0001873_stomach_inflammation1.74672494
25MP0001849_ear_inflammation1.73413758
26MP0002796_impaired_skin_barrier1.72018614
27MP0002396_abnormal_hematopoietic_system1.71712092
28MP0000350_abnormal_cell_proliferation1.68059661
29MP0004381_abnormal_hair_follicle1.65901884
30MP0002822_catalepsy1.64262163
31MP0009379_abnormal_foot_pigmentation1.60652242
32MP0000313_abnormal_cell_death1.60033535
33MP0001661_extended_life_span1.57337731
34MP0009672_abnormal_birth_weight1.54298884
35MP0005423_abnormal_somatic_nervous1.45979255
36MP0003705_abnormal_hypodermis_morpholog1.43471260
37MP0006036_abnormal_mitochondrial_physio1.42987503
38MP0006035_abnormal_mitochondrial_morpho1.40958239
39MP0003806_abnormal_nucleotide_metabolis1.38853311
40MP0002163_abnormal_gland_morphology1.37629399
41MP0002132_abnormal_respiratory_system1.37484071
42MP0000703_abnormal_thymus_morphology1.34171949
43MP0002080_prenatal_lethality1.33015582
44MP0004233_abnormal_muscle_weight1.32803664
45MP0002089_abnormal_postnatal_growth/wei1.29765305
46MP0000490_abnormal_crypts_of1.29260942
47MP0001697_abnormal_embryo_size1.23620659
48MP0001348_abnormal_lacrimal_gland1.20072181
49MP0005380_embryogenesis_phenotype1.19185910
50MP0001672_abnormal_embryogenesis/_devel1.19185910
51MP0003942_abnormal_urinary_system1.18332295
52MP0002085_abnormal_embryonic_tissue1.12950539
53MP0005076_abnormal_cell_differentiation1.12124653
54MP0003984_embryonic_growth_retardation1.11670997
55MP0000003_abnormal_adipose_tissue1.10881687
56MP0005058_abnormal_lysosome_morphology1.10173437
57MP0002088_abnormal_embryonic_growth/wei1.08259210
58MP0001346_abnormal_lacrimal_gland1.02898010
59MP0009278_abnormal_bone_marrow1.01678866
60MP0002019_abnormal_tumor_incidence0.97500386
61MP0001188_hyperpigmentation0.95903278
62MP0002697_abnormal_eye_size0.93747254
63MP0000358_abnormal_cell_content/0.92596310
64MP0000537_abnormal_urethra_morphology0.92029563
65MP0001293_anophthalmia0.91461923
66MP0006292_abnormal_olfactory_placode0.89662861
67MP0005083_abnormal_biliary_tract0.88126703
68MP0005377_hearing/vestibular/ear_phenot0.86281716
69MP0003878_abnormal_ear_physiology0.86281716
70MP0002932_abnormal_joint_morphology0.84040686
71MP0004858_abnormal_nervous_system0.81279080
72MP0003315_abnormal_perineum_morphology0.80197408
73MP0002177_abnormal_outer_ear0.80010727
74MP0001186_pigmentation_phenotype0.79504531
75MP0002111_abnormal_tail_morphology0.79355518
76MP0003763_abnormal_thymus_physiology0.79245201
77MP0002277_abnormal_respiratory_mucosa0.77841436
78MP0003186_abnormal_redox_activity0.76881509
79MP0003938_abnormal_ear_development0.76502937
80MP0001764_abnormal_homeostasis0.75958973
81MP0002086_abnormal_extraembryonic_tissu0.74782044
82MP0005645_abnormal_hypothalamus_physiol0.74495760
83MP0000015_abnormal_ear_pigmentation0.72861640
84MP0001270_distended_abdomen0.71737994
85MP0000681_abnormal_thyroid_gland0.71300545
86MP0002075_abnormal_coat/hair_pigmentati0.71193377
87MP0005666_abnormal_adipose_tissue0.71045225
88MP0009931_abnormal_skin_appearance0.70749682
89MP0005375_adipose_tissue_phenotype0.70043618
90MP0000462_abnormal_digestive_system0.69171156
91MP0002138_abnormal_hepatobiliary_system0.69126448
92MP0009053_abnormal_anal_canal0.68623838
93MP0000733_abnormal_muscle_development0.67662957
94MP0005499_abnormal_olfactory_system0.65417326
95MP0005394_taste/olfaction_phenotype0.65417326
96MP0002084_abnormal_developmental_patter0.65022707
97MP0004197_abnormal_fetal_growth/weight/0.64725671
98MP0002722_abnormal_immune_system0.63187823
99MP0000762_abnormal_tongue_morphology0.63001090
100MP0004808_abnormal_hematopoietic_stem0.62370286

Predicted human phenotypes

RankGene SetZ-score
1Congenital malformation of the right heart (HP:0011723)4.70961402
2Double outlet right ventricle (HP:0001719)4.70961402
3Truncus arteriosus (HP:0001660)4.32035269
4Abnormality of cells of the erythroid lineage (HP:0012130)4.09045485
5Abnormal number of erythroid precursors (HP:0012131)4.07462466
6Microvesicular hepatic steatosis (HP:0001414)3.74357700
7Progressive muscle weakness (HP:0003323)3.51513650
8Reticulocytopenia (HP:0001896)3.50993865
9Aplasia/Hypoplasia of the sacrum (HP:0008517)3.31414371
10Abnormality of the aortic arch (HP:0012303)3.13296711
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10131607
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10131607
13Ragged-red muscle fibers (HP:0003200)3.07402735
14Hypertensive crisis (HP:0100735)3.00975229
15Hyperthyroidism (HP:0000836)2.95314147
16Abnormal mitochondria in muscle tissue (HP:0008316)2.91123073
17Squamous cell carcinoma (HP:0002860)2.76163899
18Testicular atrophy (HP:0000029)2.75347783
19Seborrheic dermatitis (HP:0001051)2.73083172
20Increased intramyocellular lipid droplets (HP:0012240)2.68569708
21Hepatocellular necrosis (HP:0001404)2.67559318
22Increased muscle lipid content (HP:0009058)2.66164925
23Poikiloderma (HP:0001029)2.60058636
24Abnormal ventriculo-arterial connection (HP:0011563)2.56581157
25Transposition of the great arteries (HP:0001669)2.56581157
26Abnormal connection of the cardiac segments (HP:0011545)2.56581157
27Rough bone trabeculation (HP:0100670)2.51999862
28Unilateral renal agenesis (HP:0000122)2.51485293
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49303258
30Macrocytic anemia (HP:0001972)2.47461249
31Preauricular pit (HP:0004467)2.45975040
32Periauricular skin pits (HP:0100277)2.45975040
33Mitochondrial inheritance (HP:0001427)2.44362208
34Abnormality of reticulocytes (HP:0004312)2.43279813
35Acute lymphatic leukemia (HP:0006721)2.38246214
36Abnormal pupillary function (HP:0007686)2.37759259
37Selective tooth agenesis (HP:0001592)2.35139988
38Broad distal phalanx of finger (HP:0009836)2.35107194
39Stridor (HP:0010307)2.33588011
40Acute necrotizing encephalopathy (HP:0006965)2.33243607
41Birth length less than 3rd percentile (HP:0003561)2.31733685
42Hypoplastic left heart (HP:0004383)2.28392640
43Respiratory difficulties (HP:0002880)2.27884814
44Pallor (HP:0000980)2.26550138
45Secondary amenorrhea (HP:0000869)2.26093918
46Hepatic necrosis (HP:0002605)2.26007705
47Cholecystitis (HP:0001082)2.24808198
48Abnormal gallbladder physiology (HP:0012438)2.24808198
49Acute encephalopathy (HP:0006846)2.21590335
50Increased CSF lactate (HP:0002490)2.21575663
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20781851
52Exercise intolerance (HP:0003546)2.19913085
53Abnormal number of incisors (HP:0011064)2.17590605
54Increased serum lactate (HP:0002151)2.16494879
55Cholelithiasis (HP:0001081)2.09415751
56Spastic diplegia (HP:0001264)2.09393594
57Long palpebral fissure (HP:0000637)2.06626912
58Lactic acidosis (HP:0003128)2.06210562
59Turricephaly (HP:0000262)2.05839335
60Abnormal trabecular bone morphology (HP:0100671)2.05132243
61Cerebral hypomyelination (HP:0006808)2.04753909
62Hypokinesia (HP:0002375)2.04551969
63Hypoparathyroidism (HP:0000829)2.04240794
64Hyperacusis (HP:0010780)2.04021165
65Abnormality of the tricuspid valve (HP:0001702)2.01897589
66Renal Fanconi syndrome (HP:0001994)2.01695183
67Abnormally folded helix (HP:0008544)2.01360786
68Chromsome breakage (HP:0040012)1.99224210
69Breast hypoplasia (HP:0003187)1.98816156
70Premature skin wrinkling (HP:0100678)1.98485207
71Neoplasm of the adrenal cortex (HP:0100641)1.98237738
72Entropion (HP:0000621)1.97085098
73Hypoplastic heart (HP:0001961)1.96655180
74Emotional lability (HP:0000712)1.95392160
75Deep palmar crease (HP:0006191)1.94357069
76Increased hepatocellular lipid droplets (HP:0006565)1.93357277
77Microretrognathia (HP:0000308)1.92604716
78Reticulocytosis (HP:0001923)1.92257367
79Abnormality of DNA repair (HP:0003254)1.89865097
80Abnormal gallbladder morphology (HP:0012437)1.88701221
81Abnormal large intestine physiology (HP:0012700)1.88533919
82Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88439777
83Overfolded helix (HP:0000396)1.87234434
84Lipid accumulation in hepatocytes (HP:0006561)1.85189629
85Bowel incontinence (HP:0002607)1.84651864
86Atelectasis (HP:0100750)1.84599165
87Bulbar palsy (HP:0001283)1.84507588
88Abnormality of pyrimidine metabolism (HP:0004353)1.84436335
89Abnormality of the parathyroid morphology (HP:0011766)1.83702063
90Hypergonadotropic hypogonadism (HP:0000815)1.81860930
91Optic nerve coloboma (HP:0000588)1.79939528
92Limb hypertonia (HP:0002509)1.79370996
93Myopathic facies (HP:0002058)1.79368314
94Abnormality of T cell physiology (HP:0011840)1.78326354
95Colon cancer (HP:0003003)1.76561785
96Premature ovarian failure (HP:0008209)1.75647200
97Gastrointestinal dysmotility (HP:0002579)1.74474188
98Abnormality of the gallbladder (HP:0005264)1.73748609
99Progressive external ophthalmoplegia (HP:0000590)1.72973862
100Muscle fiber atrophy (HP:0100295)1.71239721

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG15.89317984
2VRK25.14751778
3NME23.98726839
4TRIB33.83795049
5BUB13.60663997
6TAF13.13106535
7STK162.76218631
8NME12.32919433
9TLK12.12422375
10PRKD32.08546374
11EEF2K1.91101464
12ICK1.79568182
13IRAK31.71225473
14CDC71.49776404
15MAP3K101.48279593
16TESK21.39910139
17IRAK21.34492021
18PRPF4B1.33317589
19SIK11.28720318
20DAPK11.27351267
21CDK71.25167386
22ERN11.22009512
23VRK11.21409930
24MAP4K11.20147802
25TTK1.13366006
26CHEK21.12691010
27CDK121.09222245
28AURKA1.06814444
29NUAK11.04302790
30CDK41.03205776
31MAPK111.00204791
32RPS6KB20.99422857
33FGFR40.91532684
34CAMK1D0.88288116
35ATR0.88237232
36MAP2K20.87501666
37MAP2K30.87036536
38BRSK10.86631581
39MAPKAPK50.86570186
40KDR0.84467745
41BCKDK0.83904191
42PAK40.83813457
43EIF2AK10.80271928
44PTK60.77265096
45SIK20.76782030
46TSSK60.76047584
47BMX0.75372515
48ABL20.73888158
49CSNK1G30.73658725
50MAP3K80.73580591
51DYRK20.73517591
52PLK40.72421939
53PASK0.71054010
54MAP3K110.68315413
55MTOR0.67935592
56BRAF0.67034105
57DAPK30.66279823
58AURKB0.65859114
59TESK10.65194647
60TYK20.64589205
61CHEK10.64375933
62ALK0.63511595
63ILK0.60571592
64GRK60.60285400
65SRPK10.60165867
66MARK20.59625136
67TAOK20.57980115
68PIM20.57813900
69IRAK40.57764060
70MAP3K90.57723433
71PRKCI0.57233797
72CDK90.55254139
73PKN20.55040930
74STK40.52835176
75TNK20.52144591
76PDPK10.52082910
77PBK0.52034010
78NEK20.51010059
79PRKD20.50198512
80CSNK1A1L0.49300540
81HIPK20.44546032
82MAPK120.43951196
83MAP2K60.43252038
84EIF2AK20.42615235
85LRRK20.42551009
86AKT20.42466284
87TBK10.42203799
88CDK20.41137271
89CSNK1G10.40685580
90PLK10.39526163
91CSNK2A20.39522404
92MELK0.38091554
93CSNK1G20.37908704
94CDK10.37354696
95CDK80.36637981
96RPS6KL10.35972808
97RPS6KC10.35972808
98CAMKK10.32984001
99CDK11A0.31962516
100CSNK2A10.31176999

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041225.23198580
2Ribosome_Homo sapiens_hsa030104.58443442
3DNA replication_Homo sapiens_hsa030304.02118766
4Base excision repair_Homo sapiens_hsa034103.24008947
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53678326
6Mismatch repair_Homo sapiens_hsa034302.37074831
7Spliceosome_Homo sapiens_hsa030402.31932530
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.24756460
9RNA polymerase_Homo sapiens_hsa030202.19265061
10Biosynthesis of amino acids_Homo sapiens_hsa012302.14765767
11Proteasome_Homo sapiens_hsa030502.12954849
12Pyrimidine metabolism_Homo sapiens_hsa002402.03601962
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.02684541
14Homologous recombination_Homo sapiens_hsa034401.83919378
15Cysteine and methionine metabolism_Homo sapiens_hsa002701.83531242
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80080190
17Oxidative phosphorylation_Homo sapiens_hsa001901.79068032
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78920237
19One carbon pool by folate_Homo sapiens_hsa006701.69927727
20Nucleotide excision repair_Homo sapiens_hsa034201.63129055
21RNA transport_Homo sapiens_hsa030131.62309864
22Parkinsons disease_Homo sapiens_hsa050121.59814078
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58127330
24Notch signaling pathway_Homo sapiens_hsa043301.51723945
25Fructose and mannose metabolism_Homo sapiens_hsa000511.51069995
26Vitamin B6 metabolism_Homo sapiens_hsa007501.50279593
27Non-homologous end-joining_Homo sapiens_hsa034501.50204343
28Phenylalanine metabolism_Homo sapiens_hsa003601.48070227
29Fanconi anemia pathway_Homo sapiens_hsa034601.38389541
30Carbon metabolism_Homo sapiens_hsa012001.32603156
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31103459
32Pentose phosphate pathway_Homo sapiens_hsa000301.26710462
33Huntingtons disease_Homo sapiens_hsa050161.24988003
34Cell cycle_Homo sapiens_hsa041101.23211415
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19753492
36Alzheimers disease_Homo sapiens_hsa050101.19102124
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04537410
38Purine metabolism_Homo sapiens_hsa002300.96750662
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95858229
40Central carbon metabolism in cancer_Homo sapiens_hsa052300.94087410
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94022490
42mRNA surveillance pathway_Homo sapiens_hsa030150.91882124
43Basal cell carcinoma_Homo sapiens_hsa052170.89829713
44Sulfur metabolism_Homo sapiens_hsa009200.87310687
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86817713
46Lysine degradation_Homo sapiens_hsa003100.86546565
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84769817
48Galactose metabolism_Homo sapiens_hsa000520.84751052
49Non-small cell lung cancer_Homo sapiens_hsa052230.84492562
50Folate biosynthesis_Homo sapiens_hsa007900.83317276
51Pyruvate metabolism_Homo sapiens_hsa006200.80623155
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80452121
53Bladder cancer_Homo sapiens_hsa052190.78563018
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77362732
55N-Glycan biosynthesis_Homo sapiens_hsa005100.75913511
56Acute myeloid leukemia_Homo sapiens_hsa052210.73336621
57Chronic myeloid leukemia_Homo sapiens_hsa052200.71149522
58Thyroid cancer_Homo sapiens_hsa052160.70744891
59Basal transcription factors_Homo sapiens_hsa030220.67824912
60Arginine biosynthesis_Homo sapiens_hsa002200.67375114
61Epstein-Barr virus infection_Homo sapiens_hsa051690.66123485
62Tyrosine metabolism_Homo sapiens_hsa003500.65834725
63Arginine and proline metabolism_Homo sapiens_hsa003300.64754874
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64505239
65Metabolic pathways_Homo sapiens_hsa011000.62643456
66Glutathione metabolism_Homo sapiens_hsa004800.60822899
67Other glycan degradation_Homo sapiens_hsa005110.60214095
68Fatty acid elongation_Homo sapiens_hsa000620.58225039
69Endometrial cancer_Homo sapiens_hsa052130.53278100
70Selenocompound metabolism_Homo sapiens_hsa004500.52073650
71mTOR signaling pathway_Homo sapiens_hsa041500.47028933
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46275004
73VEGF signaling pathway_Homo sapiens_hsa043700.45167615
74HTLV-I infection_Homo sapiens_hsa051660.44668494
75p53 signaling pathway_Homo sapiens_hsa041150.43501829
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43328389
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40099190
78Prion diseases_Homo sapiens_hsa050200.35729295
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34326291
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34307983
81B cell receptor signaling pathway_Homo sapiens_hsa046620.34304053
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.32316823
83Herpes simplex infection_Homo sapiens_hsa051680.32297446
84Primary immunodeficiency_Homo sapiens_hsa053400.32122799
85Viral carcinogenesis_Homo sapiens_hsa052030.31890936
86Colorectal cancer_Homo sapiens_hsa052100.31826123
87Fatty acid metabolism_Homo sapiens_hsa012120.31769361
88Vibrio cholerae infection_Homo sapiens_hsa051100.31466740
89Apoptosis_Homo sapiens_hsa042100.31151733
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28478278
91Insulin signaling pathway_Homo sapiens_hsa049100.27523553
92RNA degradation_Homo sapiens_hsa030180.26963786
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26581151
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25685894
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25443287
96Hedgehog signaling pathway_Homo sapiens_hsa043400.24037977
97Glioma_Homo sapiens_hsa052140.23230933
98Pancreatic cancer_Homo sapiens_hsa052120.22694830
99Steroid biosynthesis_Homo sapiens_hsa001000.22017932
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21189629

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