C9ORF116

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)8.24046870
2left/right pattern formation (GO:0060972)8.05045847
3regulation of cilium movement (GO:0003352)7.20956723
4intraciliary transport (GO:0042073)6.69328518
5ventricular system development (GO:0021591)5.86899598
6left/right axis specification (GO:0070986)5.75041128
7primary alcohol catabolic process (GO:0034310)5.55300798
8microtubule bundle formation (GO:0001578)5.47250999
9cilium organization (GO:0044782)5.42265789
10cilium assembly (GO:0042384)5.31498407
11centriole assembly (GO:0098534)4.63535699
12vitamin transmembrane transport (GO:0035461)4.56977578
13nucleoside diphosphate phosphorylation (GO:0006165)4.55988200
14regulation of microtubule-based movement (GO:0060632)4.43162624
15protein localization to cilium (GO:0061512)4.35864410
16ethanol metabolic process (GO:0006067)4.34556633
17microtubule-based movement (GO:0007018)4.17429444
18sperm capacitation (GO:0048240)4.15150504
19cellular component assembly involved in morphogenesis (GO:0010927)4.12007541
20cilium morphogenesis (GO:0060271)4.08634420
21establishment of apical/basal cell polarity (GO:0035089)4.01916498
22establishment of monopolar cell polarity (GO:0061162)3.99758482
23establishment or maintenance of monopolar cell polarity (GO:0061339)3.99758482
24negative regulation of T cell differentiation in thymus (GO:0033085)3.89607488
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.86909739
26diterpenoid biosynthetic process (GO:0016102)3.86817165
27GTP biosynthetic process (GO:0006183)3.73976065
28aldehyde catabolic process (GO:0046185)3.73591311
29microtubule depolymerization (GO:0007019)3.68552261
30pyrimidine-containing compound transmembrane transport (GO:0072531)3.66993784
31lung epithelium development (GO:0060428)3.61327578
32cell projection assembly (GO:0030031)3.59839644
33sperm motility (GO:0030317)3.53919647
34one-carbon compound transport (GO:0019755)3.50348561
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48486169
36response to xenobiotic stimulus (GO:0009410)3.38893403
37terpenoid biosynthetic process (GO:0016114)3.38122853
38centriole replication (GO:0007099)3.31814867
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.31313103
40microtubule polymerization or depolymerization (GO:0031109)3.30767247
41UTP biosynthetic process (GO:0006228)3.29600032
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27044800
43ethanol oxidation (GO:0006069)3.25403104
44pyrimidine nucleotide catabolic process (GO:0006244)3.23657704
45ATP synthesis coupled proton transport (GO:0015986)3.18218711
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18218711
47base-excision repair, AP site formation (GO:0006285)3.16103595
48glutathione derivative biosynthetic process (GO:1901687)3.14299485
49glutathione derivative metabolic process (GO:1901685)3.14299485
50establishment of tissue polarity (GO:0007164)3.10484871
51establishment of planar polarity (GO:0001736)3.10484871
52lateral ventricle development (GO:0021670)3.08774367
53retinoic acid metabolic process (GO:0042573)3.06648793
54nonmotile primary cilium assembly (GO:0035058)3.04512864
55glomerular epithelial cell development (GO:0072310)2.98754914
56determination of left/right symmetry (GO:0007368)2.98621989
57UTP metabolic process (GO:0046051)2.95621653
58ribosomal small subunit assembly (GO:0000028)2.93831549
59nucleotide phosphorylation (GO:0046939)2.92332818
60smoothened signaling pathway (GO:0007224)2.92135704
61CTP biosynthetic process (GO:0006241)2.90497653
62CTP metabolic process (GO:0046036)2.90497653
63hydrogen peroxide catabolic process (GO:0042744)2.90481532
64chaperone-mediated protein transport (GO:0072321)2.89579615
65viral transcription (GO:0019083)2.89048847
66electron transport chain (GO:0022900)2.87660051
67determination of bilateral symmetry (GO:0009855)2.83759885
68cytoplasmic microtubule organization (GO:0031122)2.83116114
69respiratory electron transport chain (GO:0022904)2.80755486
70translational termination (GO:0006415)2.80178524
71specification of symmetry (GO:0009799)2.79039459
72pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.77607524
73protein polyglutamylation (GO:0018095)2.77484998
74regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.77431128
75positive regulation of smoothened signaling pathway (GO:0045880)2.76838935
76nucleoside triphosphate biosynthetic process (GO:0009142)2.72961777
77microtubule-based process (GO:0007017)2.64561524
78nucleoside diphosphate metabolic process (GO:0009132)2.64016711
79pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.63085985
80purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.62352108
81purine nucleoside triphosphate biosynthetic process (GO:0009145)2.57863830
82pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.56300816
83organelle assembly (GO:0070925)2.55834422
84ribosomal small subunit biogenesis (GO:0042274)2.54911124
85regulation of microtubule depolymerization (GO:0031114)2.54798147
86guanosine-containing compound biosynthetic process (GO:1901070)2.50532222
87primary alcohol metabolic process (GO:0034308)2.49945186
88myoblast migration (GO:0051451)2.45875711
89SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.44871306
90cotranslational protein targeting to membrane (GO:0006613)2.44142204
91lateral sprouting from an epithelium (GO:0060601)2.43886348
92regulation of interleukin-5 production (GO:0032674)2.43599365
93tolerance induction (GO:0002507)2.43483428
94protein targeting to ER (GO:0045047)2.42714775
95axonemal dynein complex assembly (GO:0070286)18.2932992
96cilium or flagellum-dependent cell motility (GO:0001539)13.2734624
97cilium movement (GO:0003341)12.8863827
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.9370821
99motile cilium assembly (GO:0044458)11.8683423
100epithelial cilium movement (GO:0003351)11.8095870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat9.05398197
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.80414475
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64581206
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.60415444
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25428470
6SIN3A_21632747_ChIP-Seq_MESCs_Mouse2.21467869
7SIN3B_21632747_ChIP-Seq_MESCs_Mouse2.18293606
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.16764599
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12851381
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.86106161
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.84041858
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75740059
13EST1_17652178_ChIP-ChIP_JURKAT_Human1.75420554
14DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.73056151
15ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69809675
16ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67938884
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66271825
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66114560
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.64886291
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.62106974
21XRN2_22483619_ChIP-Seq_HELA_Human1.57851301
22CTCF_27219007_Chip-Seq_Bcells_Human1.54565845
23GABP_19822575_ChIP-Seq_HepG2_Human1.53947008
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.51364595
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49873555
26YY1_22570637_ChIP-Seq_MALME-3M_Human1.45343457
27* SMC4_20622854_ChIP-Seq_HELA_Human1.42617086
28STAT1_20625510_ChIP-Seq_HELA_Human1.41722021
29SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39393199
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39310605
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36196490
32DROSHA_22980978_ChIP-Seq_HELA_Human1.34890313
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34720882
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.32056227
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31798902
36CTCF_20526341_ChIP-Seq_ESCs_Human1.30853899
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30696732
38P68_20966046_ChIP-Seq_HELA_Human1.30689098
39ELF1_20517297_ChIP-Seq_JURKAT_Human1.30679827
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.29181117
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27773419
42RAD21_21589869_ChIP-Seq_MESCs_Mouse1.26248732
43PHF8_20622854_ChIP-Seq_HELA_Human1.24628810
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23001878
45ZNF263_19887448_ChIP-Seq_K562_Human1.21578162
46SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21095298
47GATA1_26923725_Chip-Seq_HPCs_Mouse1.20840825
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13487024
49* FOXP1_21924763_ChIP-Seq_HESCs_Human1.12636502
50RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12289129
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12089828
52VDR_22108803_ChIP-Seq_LS180_Human1.11441962
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10492918
54TTF2_22483619_ChIP-Seq_HELA_Human1.10199285
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.07490180
56DCP1A_22483619_ChIP-Seq_HELA_Human1.07466972
57TP63_22573176_ChIP-Seq_HFKS_Human1.05689662
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.05181118
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03264634
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02084364
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99569368
62PHF8_20622853_ChIP-Seq_HELA_Human0.99178940
63TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97646477
64FLI1_21867929_ChIP-Seq_CD8_Mouse0.97309195
65ERA_21632823_ChIP-Seq_H3396_Human0.96865592
66RBPJ_21746931_ChIP-Seq_IB4_Human0.96499951
67TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95730800
68SOX2_21211035_ChIP-Seq_LN229_Human0.95329709
69PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94639615
70RUNX1_27514584_Chip-Seq_MCF-7_Human0.94396215
71* E2F1_20622854_ChIP-Seq_HELA_Human0.94140670
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90533919
73CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90364721
74MYC_18940864_ChIP-ChIP_HL60_Human0.89320654
75STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88803293
76ETV1_20927104_ChIP-Seq_GIST48_Human0.88707008
77BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87406169
78SA1_27219007_Chip-Seq_ERYTHROID_Human0.86843004
79PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86803599
80PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.86142248
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85836187
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85809144
83TET1_21451524_ChIP-Seq_MESCs_Mouse0.85647298
84SA1_27219007_Chip-Seq_Bcells_Human0.85618799
85E2F1_17053090_ChIP-ChIP_MCF-7_Human0.85393647
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85050693
87FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.83400913
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82967305
89HNFA_21074721_ChIP-Seq_CACO-2_Human0.82896421
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82874470
91SOX2_22085726_ChIP-Seq_NPCs_Mouse0.82641661
92RARA_24833708_ChIP-Seq_LIVER_Mouse0.82363514
93P300_27268052_Chip-Seq_Bcells_Human0.82143221
94CREB1_26743006_Chip-Seq_LNCaP_Human0.81128814
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80701630
96GATA6_21074721_ChIP-Seq_CACO-2_Human0.78987461
97ERG_20517297_ChIP-Seq_VCAP_Human0.78660680
98NANOG_20526341_ChIP-Seq_ESCs_Human0.78171414
99SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77327959
100AR_20517297_ChIP-Seq_VCAP_Human0.77303701

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.54251971
2MP0008875_abnormal_xenobiotic_pharmacok4.40883527
3MP0009379_abnormal_foot_pigmentation3.72898733
4MP0008789_abnormal_olfactory_epithelium3.72566333
5MP0002132_abnormal_respiratory_system3.51332148
6MP0004133_heterotaxia3.33859273
7MP0010030_abnormal_orbit_morphology3.08639542
8MP0001984_abnormal_olfaction3.08350496
9MP0005499_abnormal_olfactory_system2.94656376
10MP0005394_taste/olfaction_phenotype2.94656376
11MP0000566_synostosis2.88314680
12MP0004043_abnormal_pH_regulation2.56496391
13MP0005623_abnormal_meninges_morphology2.39713947
14MP0005377_hearing/vestibular/ear_phenot2.25449501
15MP0003878_abnormal_ear_physiology2.25449501
16MP0006292_abnormal_olfactory_placode2.22501504
17MP0002160_abnormal_reproductive_system2.14390453
18MP0002277_abnormal_respiratory_mucosa2.12207070
19MP0003136_yellow_coat_color2.05863349
20MP0001293_anophthalmia2.02097714
21MP0003123_paternal_imprinting1.81342857
22MP0002282_abnormal_trachea_morphology1.68613164
23MP0004019_abnormal_vitamin_homeostasis1.65905278
24MP0002822_catalepsy1.65080327
25MP0009780_abnormal_chondrocyte_physiolo1.63247974
26MP0001188_hyperpigmentation1.57306325
27MP0005083_abnormal_biliary_tract1.52546171
28MP0000049_abnormal_middle_ear1.52009383
29MP0002233_abnormal_nose_morphology1.50961894
30MP0002249_abnormal_larynx_morphology1.46603009
31MP0001485_abnormal_pinna_reflex1.45419694
32MP0001529_abnormal_vocalization1.43794492
33MP0003890_abnormal_embryonic-extraembry1.40511928
34MP0003186_abnormal_redox_activity1.35828374
35MP0001346_abnormal_lacrimal_gland1.34988973
36MP0002638_abnormal_pupillary_reflex1.29644437
37MP0003941_abnormal_skin_development1.25096902
38MP0002734_abnormal_mechanical_nocicepti1.21929451
39MP0005248_abnormal_Harderian_gland1.20825055
40MP0003937_abnormal_limbs/digits/tail_de1.19468593
41MP0000678_abnormal_parathyroid_gland1.14320090
42MP0000026_abnormal_inner_ear1.13221235
43MP0003942_abnormal_urinary_system1.10854682
44MP0003938_abnormal_ear_development1.10252148
45MP0005389_reproductive_system_phenotype1.10060020
46MP0003698_abnormal_male_reproductive1.05033829
47MP0003861_abnormal_nervous_system1.04635555
48MP0005408_hypopigmentation1.01985782
49MP0001929_abnormal_gametogenesis1.01635097
50MP0006072_abnormal_retinal_apoptosis1.01052462
51MP0006036_abnormal_mitochondrial_physio0.98447537
52MP0003806_abnormal_nucleotide_metabolis0.96976831
53MP0000955_abnormal_spinal_cord0.96718160
54MP0000383_abnormal_hair_follicle0.92418289
55MP0002092_abnormal_eye_morphology0.89361038
56MP0002909_abnormal_adrenal_gland0.88067933
57MP0005391_vision/eye_phenotype0.87388760
58MP0000631_abnormal_neuroendocrine_gland0.87089875
59MP0000778_abnormal_nervous_system0.86797951
60MP0005195_abnormal_posterior_eye0.84845940
61MP0008932_abnormal_embryonic_tissue0.81344962
62MP0003011_delayed_dark_adaptation0.81059648
63MP0002234_abnormal_pharynx_morphology0.80728780
64MP0001286_abnormal_eye_development0.80715491
65MP0001299_abnormal_eye_distance/0.80695194
66MP0002084_abnormal_developmental_patter0.80417376
67MP0002938_white_spotting0.79921150
68MP0003693_abnormal_embryo_hatching0.79551354
69MP0002116_abnormal_craniofacial_bone0.79491528
70MP0002752_abnormal_somatic_nervous0.79355495
71MP0005551_abnormal_eye_electrophysiolog0.78348262
72MP0001963_abnormal_hearing_physiology0.78186182
73MP0009053_abnormal_anal_canal0.75360245
74MP0002557_abnormal_social/conspecific_i0.75111938
75MP0002210_abnormal_sex_determination0.74994601
76MP0005253_abnormal_eye_physiology0.74800636
77MP0003718_maternal_effect0.74246573
78MP0004957_abnormal_blastocyst_morpholog0.73321696
79MP0005636_abnormal_mineral_homeostasis0.72704236
80MP0002085_abnormal_embryonic_tissue0.72049295
81MP0008995_early_reproductive_senescence0.70543923
82MP0003119_abnormal_digestive_system0.70395374
83MP0002161_abnormal_fertility/fecundity0.70089445
84MP0005395_other_phenotype0.67774372
85MP0002152_abnormal_brain_morphology0.67486910
86MP0001145_abnormal_male_reproductive0.67104406
87MP0001727_abnormal_embryo_implantation0.64385200
88MP0000653_abnormal_sex_gland0.63864985
89MP0001905_abnormal_dopamine_level0.63549235
90MP0001324_abnormal_eye_pigmentation0.63371741
91MP0009046_muscle_twitch0.62063447
92MP0001765_abnormal_ion_homeostasis0.61739250
93MP0002168_other_aberrant_phenotype0.61696408
94MP0002111_abnormal_tail_morphology0.60968417
95MP0010678_abnormal_skin_adnexa0.60801995
96MP0002736_abnormal_nociception_after0.60788813
97MP0002882_abnormal_neuron_morphology0.60428797
98MP0002163_abnormal_gland_morphology0.60134662
99MP0008058_abnormal_DNA_repair0.57296018
100MP0006276_abnormal_autonomic_nervous0.56564845

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.87909071
2Absent/shortened dynein arms (HP:0200106)9.87909071
3Rhinitis (HP:0012384)9.39534281
4Chronic bronchitis (HP:0004469)7.50732726
5Bronchiectasis (HP:0002110)6.71102815
6Nasal polyposis (HP:0100582)6.00649343
7Abnormality of the nasal mucosa (HP:0000433)4.83351358
8Infertility (HP:0000789)4.25229098
9Occipital encephalocele (HP:0002085)3.98647225
10Pancreatic fibrosis (HP:0100732)3.86790152
11True hermaphroditism (HP:0010459)3.80067483
12Chronic sinusitis (HP:0011109)3.67246557
13Male infertility (HP:0003251)3.55383887
14Bronchitis (HP:0012387)3.54490204
15Recurrent sinusitis (HP:0011108)3.41534794
16Recurrent otitis media (HP:0000403)3.28301825
17Molar tooth sign on MRI (HP:0002419)3.22212528
18Abnormality of midbrain morphology (HP:0002418)3.22212528
19Nephronophthisis (HP:0000090)3.18854669
20Pancreatic cysts (HP:0001737)3.09617931
21Atelectasis (HP:0100750)3.03617549
22Cystic liver disease (HP:0006706)2.98402565
23Postaxial foot polydactyly (HP:0001830)2.87537463
24Anencephaly (HP:0002323)2.60259762
25Sclerocornea (HP:0000647)2.43121041
26Abnormality of the renal medulla (HP:0100957)2.40432628
27Medial flaring of the eyebrow (HP:0010747)2.39900472
28Chronic hepatic failure (HP:0100626)2.37171382
29Aplasia/Hypoplasia of the tongue (HP:0010295)2.34759765
30Tubulointerstitial nephritis (HP:0001970)2.29917187
31Male pseudohermaphroditism (HP:0000037)2.21833160
32Congenital primary aphakia (HP:0007707)2.21559311
33Hyperactive renin-angiotensin system (HP:0000841)2.21166688
34Gait imbalance (HP:0002141)2.19575280
35Congenital hepatic fibrosis (HP:0002612)2.18548757
36Chronic otitis media (HP:0000389)2.15721297
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.7734642
38Abnormal respiratory epithelium morphology (HP:0012253)10.5313962
39Abnormal respiratory motile cilium morphology (HP:0005938)10.5313962
40Abnormal respiratory motile cilium physiology (HP:0012261)10.5086828
41Abnormal ciliary motility (HP:0012262)10.1726047
42Bell-shaped thorax (HP:0001591)1.97652771
43Nephrogenic diabetes insipidus (HP:0009806)1.96545397
44Postaxial hand polydactyly (HP:0001162)1.90443769
45Tubular atrophy (HP:0000092)1.89917813
46Preaxial hand polydactyly (HP:0001177)1.87334909
47Oculomotor apraxia (HP:0000657)1.85197354
48Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82584860
49Aplasia/Hypoplasia of the spleen (HP:0010451)1.81273767
50Asplenia (HP:0001746)1.81194348
51Median cleft lip (HP:0000161)1.68767926
52Supernumerary spleens (HP:0009799)1.66544086
53Acute necrotizing encephalopathy (HP:0006965)1.64722541
54Renal salt wasting (HP:0000127)1.63554199
55Furrowed tongue (HP:0000221)1.62290437
56Vaginal atresia (HP:0000148)1.59702158
57Nephropathy (HP:0000112)1.58348151
58Abnormal mitochondria in muscle tissue (HP:0008316)1.56978383
59Genital tract atresia (HP:0001827)1.54813897
60Poor coordination (HP:0002370)1.52577782
61Facial cleft (HP:0002006)1.44908312
62Acute encephalopathy (HP:0006846)1.42809454
63Mitochondrial inheritance (HP:0001427)1.37420444
64Short nail (HP:0001799)1.34127377
65Optic nerve coloboma (HP:0000588)1.32362267
66Holoprosencephaly (HP:0001360)1.32147058
67Bile duct proliferation (HP:0001408)1.28674197
68Abnormal biliary tract physiology (HP:0012439)1.28674197
69Decreased circulating renin level (HP:0003351)1.28335526
70Tubulointerstitial abnormality (HP:0001969)1.28274850
71Abnormality of permanent molar morphology (HP:0011071)1.25290344
72Abnormality of the dental root (HP:0006486)1.25290344
73Taurodontia (HP:0000679)1.25290344
74Aganglionic megacolon (HP:0002251)1.25256354
75Myokymia (HP:0002411)1.24815262
76Stage 5 chronic kidney disease (HP:0003774)1.24055561
77Broad distal phalanx of finger (HP:0009836)1.22520272
78Renal dysplasia (HP:0000110)1.20787978
79Abnormality of the distal phalanges of the toes (HP:0010182)1.19636061
80Narrow forehead (HP:0000341)1.19128056
81Short thorax (HP:0010306)1.18634592
82Increased hepatocellular lipid droplets (HP:0006565)1.17734487
83Short femoral neck (HP:0100864)1.17396214
84Retinitis pigmentosa (HP:0000510)1.16782527
85Progressive macrocephaly (HP:0004481)1.15752751
86Abnormality of dentin (HP:0010299)1.14638962
87Anophthalmia (HP:0000528)1.14513938
88Bifid scrotum (HP:0000048)1.13933273
89Abnormality of molar (HP:0011077)1.13156417
90Abnormality of molar morphology (HP:0011070)1.13156417
91Absent frontal sinuses (HP:0002688)1.13109623
92Hepatocellular necrosis (HP:0001404)1.12866625
93Multicystic kidney dysplasia (HP:0000003)1.12816766
94Absent rod-and cone-mediated responses on ERG (HP:0007688)1.12562538
95Broad foot (HP:0001769)1.12321581
96Renal Fanconi syndrome (HP:0001994)1.12203659
97Aplasia/Hypoplasia of the lens (HP:0008063)1.11807865
98Prominent nasal bridge (HP:0000426)1.11541711
99Maternal diabetes (HP:0009800)1.10625564
100Increased CSF lactate (HP:0002490)1.10099468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.35061026
2MST44.25826589
3EPHA23.61589727
4VRK23.23873592
5STK163.20292123
6NME12.55987996
7SMG12.42329408
8TTK2.35730417
9PBK2.15744340
10CDC71.90058047
11PNCK1.80365812
12MAP3K121.66214857
13BCR1.58006735
14PLK41.48051380
15LRRK21.41757897
16DYRK21.41438690
17STK241.40195328
18TESK11.29235235
19BRSK21.25973675
20MAPKAPK31.20209585
21AURKA1.13715198
22PLK11.11737626
23LIMK11.08931120
24TAF11.06589988
25NME21.06353795
26ARAF1.04171061
27MAP4K21.03180493
28MAP2K71.02615737
29BRSK11.00058409
30DYRK30.99364150
31LATS10.98964285
32WEE10.98592640
33EIF2AK10.97015088
34VRK10.95196643
35MAP3K110.87323394
36PRKCI0.83885546
37TSSK60.80320331
38DYRK1B0.78165455
39TLK10.77733749
40PTK2B0.74699317
41CDK190.73090962
42CHEK20.70012561
43ABL20.69528808
44NEK10.68757638
45CSNK1G20.65078612
46BRAF0.62842224
47BUB10.62419533
48PLK30.61894116
49MARK20.61218253
50AURKB0.60091881
51PIM20.59807153
52EPHB20.59633910
53CSNK1G30.58379771
54PRKD30.57059676
55EPHA40.56510483
56NEK60.55969776
57NUAK10.55227070
58INSRR0.54737347
59WNK30.54216925
60BCKDK0.54084517
61CAMKK10.53771088
62CAMK2G0.53022756
63MAP3K20.52046876
64MAP2K40.51424647
65SRPK10.51166603
66MST1R0.49488132
67MINK10.49004108
68CSNK1A1L0.47905376
69ERBB20.47464399
70ERBB30.45113877
71ATR0.43877661
72ILK0.42501146
73PASK0.41619443
74RPS6KB20.41183819
75MAP3K40.40967073
76CSNK1G10.40057720
77MAPKAPK50.40013227
78STK100.38585282
79PAK10.37245080
80PRKCD0.36848713
81GRK10.36612448
82ZAK0.36136377
83PRKCG0.35883093
84CAMKK20.35394382
85CSK0.34964063
86PAK40.34118941
87MAP3K30.33816812
88AKT20.33481484
89NEK20.33376431
90PLK20.32584752
91EPHB10.31964172
92CSNK1E0.31515694
93CSNK2A10.30866908
94CDK90.30584512
95DYRK1A0.30431232
96CSNK2A20.30420404
97MUSK0.30343172
98PRKACA0.27305688
99IRAK20.26679907
100STK110.25587568

Predicted pathways (KEGG)

RankGene SetZ-score
1Huntingtons disease_Homo sapiens_hsa050163.96091391
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.65690349
3Oxidative phosphorylation_Homo sapiens_hsa001903.35210910
4Ribosome_Homo sapiens_hsa030103.34053448
5Phenylalanine metabolism_Homo sapiens_hsa003603.17115162
6Chemical carcinogenesis_Homo sapiens_hsa052042.95704760
7Parkinsons disease_Homo sapiens_hsa050122.69460683
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.69017998
9Tyrosine metabolism_Homo sapiens_hsa003502.62198389
10Glutathione metabolism_Homo sapiens_hsa004802.47766516
11Histidine metabolism_Homo sapiens_hsa003402.39724240
12Proteasome_Homo sapiens_hsa030502.17422157
13beta-Alanine metabolism_Homo sapiens_hsa004102.05085081
14Alzheimers disease_Homo sapiens_hsa050101.97741247
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80029138
16Cardiac muscle contraction_Homo sapiens_hsa042601.70693815
17Mismatch repair_Homo sapiens_hsa034301.70233824
18RNA polymerase_Homo sapiens_hsa030201.61533226
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59499674
20Retinol metabolism_Homo sapiens_hsa008301.56717819
21Nucleotide excision repair_Homo sapiens_hsa034201.54659304
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44150870
23DNA replication_Homo sapiens_hsa030301.39550974
24Protein export_Homo sapiens_hsa030601.38879148
25Base excision repair_Homo sapiens_hsa034101.34468723
26Pyruvate metabolism_Homo sapiens_hsa006201.33486470
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32499080
28Sulfur relay system_Homo sapiens_hsa041221.32024757
29Fatty acid degradation_Homo sapiens_hsa000711.31466307
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30553340
31Homologous recombination_Homo sapiens_hsa034401.30524739
32Peroxisome_Homo sapiens_hsa041461.27309632
33Caffeine metabolism_Homo sapiens_hsa002321.19380690
34Pyrimidine metabolism_Homo sapiens_hsa002401.16042526
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13898073
36Basal cell carcinoma_Homo sapiens_hsa052171.13144065
37Steroid biosynthesis_Homo sapiens_hsa001001.12155688
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10970301
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09203629
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00311834
41Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98660231
42Folate biosynthesis_Homo sapiens_hsa007900.97055690
43Fanconi anemia pathway_Homo sapiens_hsa034600.96935694
44Spliceosome_Homo sapiens_hsa030400.94683907
45Hedgehog signaling pathway_Homo sapiens_hsa043400.93920996
46Metabolic pathways_Homo sapiens_hsa011000.91616851
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.90681170
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.90426151
49Purine metabolism_Homo sapiens_hsa002300.90110128
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88279686
51Tight junction_Homo sapiens_hsa045300.86669457
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82877522
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82548867
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79558794
55Fatty acid elongation_Homo sapiens_hsa000620.78770626
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77894825
57Arginine and proline metabolism_Homo sapiens_hsa003300.77850358
58Linoleic acid metabolism_Homo sapiens_hsa005910.77199502
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.75205275
60Propanoate metabolism_Homo sapiens_hsa006400.72699222
61Collecting duct acid secretion_Homo sapiens_hsa049660.70778355
62Basal transcription factors_Homo sapiens_hsa030220.68554310
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62450931
64Notch signaling pathway_Homo sapiens_hsa043300.61727039
65Sphingolipid metabolism_Homo sapiens_hsa006000.59687061
66Hippo signaling pathway_Homo sapiens_hsa043900.58236901
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58213771
68Biosynthesis of amino acids_Homo sapiens_hsa012300.57747983
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.57270009
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55725053
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52965103
72Butanoate metabolism_Homo sapiens_hsa006500.51341381
73RNA transport_Homo sapiens_hsa030130.46512878
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.46104809
75Starch and sucrose metabolism_Homo sapiens_hsa005000.45899874
76Tryptophan metabolism_Homo sapiens_hsa003800.45335609
77Nicotine addiction_Homo sapiens_hsa050330.44379819
78Carbon metabolism_Homo sapiens_hsa012000.43471695
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43217576
80RNA degradation_Homo sapiens_hsa030180.43204528
81Arachidonic acid metabolism_Homo sapiens_hsa005900.41435043
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38928366
83Vitamin B6 metabolism_Homo sapiens_hsa007500.38780122
84Vitamin digestion and absorption_Homo sapiens_hsa049770.37110714
85Phototransduction_Homo sapiens_hsa047440.36874712
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36766159
87Vibrio cholerae infection_Homo sapiens_hsa051100.36196126
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34311734
89Olfactory transduction_Homo sapiens_hsa047400.30131609
90Cell cycle_Homo sapiens_hsa041100.29987833
91p53 signaling pathway_Homo sapiens_hsa041150.28082055
92Fatty acid metabolism_Homo sapiens_hsa012120.27278674
93Axon guidance_Homo sapiens_hsa043600.25549527
94Synaptic vesicle cycle_Homo sapiens_hsa047210.24874716
95Wnt signaling pathway_Homo sapiens_hsa043100.24601231
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23518320
97mRNA surveillance pathway_Homo sapiens_hsa030150.22967855
98Non-homologous end-joining_Homo sapiens_hsa034500.22237436
99Salivary secretion_Homo sapiens_hsa049700.21451530
100Cocaine addiction_Homo sapiens_hsa050300.17953965

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