C9ORF135

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.96972280
2epithelial cilium movement (GO:0003351)9.39182673
3motile cilium assembly (GO:0044458)8.92111205
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.41496259
5axoneme assembly (GO:0035082)6.37673739
6left/right pattern formation (GO:0060972)5.38458347
7intraciliary transport (GO:0042073)4.90416784
8regulation of cilium movement (GO:0003352)4.73043650
9primary alcohol catabolic process (GO:0034310)4.55770163
10centriole assembly (GO:0098534)4.29743534
11vitamin transmembrane transport (GO:0035461)4.27021840
12ventricular system development (GO:0021591)4.12724815
13left/right axis specification (GO:0070986)4.05976445
14cilium organization (GO:0044782)3.99422498
15establishment of integrated proviral latency (GO:0075713)3.96336481
16nucleoside diphosphate phosphorylation (GO:0006165)3.86332858
17cilium assembly (GO:0042384)3.86035744
18microtubule bundle formation (GO:0001578)3.70117570
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.60273807
20establishment of apical/basal cell polarity (GO:0035089)3.56279300
21chromatin remodeling at centromere (GO:0031055)3.55493384
22establishment of protein localization to mitochondrial membrane (GO:0090151)3.49914456
23proteasome assembly (GO:0043248)3.49133939
24protein localization to cilium (GO:0061512)3.46002995
25CENP-A containing nucleosome assembly (GO:0034080)3.44971689
26intra-S DNA damage checkpoint (GO:0031573)3.42533515
27regulation of mitotic spindle checkpoint (GO:1903504)3.38328673
28regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.38328673
29protein neddylation (GO:0045116)3.36722135
30cilium morphogenesis (GO:0060271)3.30351123
31aldehyde catabolic process (GO:0046185)3.30235342
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29639663
33ethanol metabolic process (GO:0006067)3.29389226
34chaperone-mediated protein transport (GO:0072321)3.28673012
35glutathione derivative metabolic process (GO:1901685)3.20603012
36glutathione derivative biosynthetic process (GO:1901687)3.20603012
37DNA replication checkpoint (GO:0000076)3.20509261
38pyrimidine-containing compound transmembrane transport (GO:0072531)3.16496347
39regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.15330791
40establishment of viral latency (GO:0019043)3.13637978
41establishment or maintenance of monopolar cell polarity (GO:0061339)3.13006777
42establishment of monopolar cell polarity (GO:0061162)3.13006777
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12700966
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12492059
45centriole replication (GO:0007099)3.09610901
46regulation of helicase activity (GO:0051095)3.07524583
47L-serine metabolic process (GO:0006563)3.06519956
48histone exchange (GO:0043486)3.03538250
49cellular component assembly involved in morphogenesis (GO:0010927)3.00735312
50purine nucleobase biosynthetic process (GO:0009113)2.96961840
51microtubule-based movement (GO:0007018)2.96436135
52DNA replication-independent nucleosome organization (GO:0034724)2.94073343
53DNA replication-independent nucleosome assembly (GO:0006336)2.94073343
54microtubule depolymerization (GO:0007019)2.93543187
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92875999
56negative regulation of ligase activity (GO:0051352)2.92875999
57energy coupled proton transport, down electrochemical gradient (GO:0015985)2.90901580
58ATP synthesis coupled proton transport (GO:0015986)2.90901580
59nodal signaling pathway (GO:0038092)2.89684313
60microtubule polymerization or depolymerization (GO:0031109)2.87584385
61termination of RNA polymerase III transcription (GO:0006386)2.87502116
62transcription elongation from RNA polymerase III promoter (GO:0006385)2.87502116
63sperm capacitation (GO:0048240)2.85123327
64response to xenobiotic stimulus (GO:0009410)2.84550856
65negative regulation of DNA-dependent DNA replication (GO:2000104)2.83985507
66regulation of cellular amino acid metabolic process (GO:0006521)2.83690314
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82389488
68diterpenoid biosynthetic process (GO:0016102)2.81564999
69negative regulation of T cell differentiation in thymus (GO:0033085)2.81190794
70IMP biosynthetic process (GO:0006188)2.79347203
71respiratory chain complex IV assembly (GO:0008535)2.76781081
72GTP biosynthetic process (GO:0006183)2.75481262
73DNA damage response, detection of DNA damage (GO:0042769)2.74363695
74hyperosmotic salinity response (GO:0042538)2.70596960
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70265144
76terpenoid biosynthetic process (GO:0016114)2.65544427
77water-soluble vitamin biosynthetic process (GO:0042364)2.65322190
78electron transport chain (GO:0022900)2.63677561
79negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.63562750
80negative regulation of mitotic sister chromatid segregation (GO:0033048)2.63562750
81negative regulation of mitotic sister chromatid separation (GO:2000816)2.63562750
82negative regulation of sister chromatid segregation (GO:0033046)2.63562750
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.63562750
84anterior/posterior axis specification, embryo (GO:0008595)2.63519801
85cell projection assembly (GO:0030031)2.62121453
86cullin deneddylation (GO:0010388)2.61581537
87IMP metabolic process (GO:0046040)2.61537445
88respiratory electron transport chain (GO:0022904)2.61317091
89ribosome assembly (GO:0042255)2.60801143
90regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.60421464
91DNA double-strand break processing (GO:0000729)2.60214688
92determination of left/right symmetry (GO:0007368)2.59745471
93negative regulation of JUN kinase activity (GO:0043508)2.57007199
94retinoic acid metabolic process (GO:0042573)2.56795530
95lateral ventricle development (GO:0021670)2.55236159
96response to X-ray (GO:0010165)2.54106755
97histone H2A acetylation (GO:0043968)2.53220790
98negative regulation of chromosome segregation (GO:0051985)2.52947303
99axonemal dynein complex assembly (GO:0070286)13.4780320
100cilium movement (GO:0003341)10.1289657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.15151997
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.80284203
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.52242090
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.11628808
5E2F7_22180533_ChIP-Seq_HELA_Human3.04257342
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.88402571
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.61337370
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.50491896
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50308445
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47997075
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40634078
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38661658
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.37537404
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37076851
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26685339
16VDR_22108803_ChIP-Seq_LS180_Human2.26565055
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09951658
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.09633796
19NANOG_16153702_ChIP-ChIP_HESCs_Human2.05942394
20ELK1_19687146_ChIP-ChIP_HELA_Human2.05515680
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.03260377
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90866691
23PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89756186
24VDR_23849224_ChIP-Seq_CD4+_Human1.79509444
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74716013
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73746146
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.73724865
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.72943887
29DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.72485471
30NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.70452880
31EWS_26573619_Chip-Seq_HEK293_Human1.68974415
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66909028
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59822992
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59714567
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.57260983
36FOXP3_21729870_ChIP-Seq_TREG_Human1.56701502
37NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.53722434
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50064887
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48037486
40SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47051269
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46137396
42DCP1A_22483619_ChIP-Seq_HELA_Human1.45821993
43SOX2_16153702_ChIP-ChIP_HESCs_Human1.44765411
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.44571009
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43976567
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43580791
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43580791
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43580791
49MYC_18940864_ChIP-ChIP_HL60_Human1.42230689
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39869937
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39758713
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39725525
53ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.35218700
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34134275
55FUS_26573619_Chip-Seq_HEK293_Human1.33867832
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33423136
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32392078
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31618075
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30841919
60GABP_19822575_ChIP-Seq_HepG2_Human1.30330337
61TTF2_22483619_ChIP-Seq_HELA_Human1.30048833
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.29724791
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28929968
64AR_21909140_ChIP-Seq_LNCAP_Human1.28445941
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21473800
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20155949
67P300_19829295_ChIP-Seq_ESCs_Human1.19694754
68PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.17182708
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.16364929
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14867063
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14341614
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13705109
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12003470
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11325526
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10003051
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09540628
77PHF8_20622853_ChIP-Seq_HELA_Human1.09265120
78ZNF274_21170338_ChIP-Seq_K562_Hela1.08884777
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08706079
80RBPJ_21746931_ChIP-Seq_IB4_Human1.07658039
81ETV1_20927104_ChIP-Seq_GIST48_Human1.04223680
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03133737
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02475683
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02433660
85XRN2_22483619_ChIP-Seq_HELA_Human1.00704293
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00006704
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99686379
88THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99248247
89PIAS1_25552417_ChIP-Seq_VCAP_Human0.98841833
90E2F1_21310950_ChIP-Seq_MCF-7_Human0.98736165
91TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97085335
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95239844
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.95239844
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94111993
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92893581
96FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91132107
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.90920815
98CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90780762
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90145780
100SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87813978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.28165584
2MP0004133_heterotaxia4.05125640
3MP0001984_abnormal_olfaction3.35628932
4MP0008875_abnormal_xenobiotic_pharmacok3.03425157
5MP0003890_abnormal_embryonic-extraembry2.99980068
6MP0004957_abnormal_blastocyst_morpholog2.94298144
7MP0002653_abnormal_ependyma_morphology2.93393979
8MP0008789_abnormal_olfactory_epithelium2.84114913
9MP0008058_abnormal_DNA_repair2.64730221
10MP0003693_abnormal_embryo_hatching2.62382384
11MP0001188_hyperpigmentation2.58818410
12MP0002132_abnormal_respiratory_system2.46279737
13MP0002277_abnormal_respiratory_mucosa2.35242193
14MP0003718_maternal_effect2.30618482
15MP0008877_abnormal_DNA_methylation2.28094504
16MP0002254_reproductive_system_inflammat2.19116850
17MP0003806_abnormal_nucleotide_metabolis2.17134973
18MP0010094_abnormal_chromosome_stability2.09236882
19MP0005499_abnormal_olfactory_system2.04422934
20MP0005394_taste/olfaction_phenotype2.04422934
21MP0001293_anophthalmia1.96804187
22MP0003111_abnormal_nucleus_morphology1.82993164
23MP0008932_abnormal_embryonic_tissue1.76970365
24MP0004043_abnormal_pH_regulation1.72486378
25MP0004019_abnormal_vitamin_homeostasis1.69529837
26MP0003186_abnormal_redox_activity1.63542101
27MP0003119_abnormal_digestive_system1.63284215
28MP0010030_abnormal_orbit_morphology1.61862119
29MP0008007_abnormal_cellular_replicative1.59404143
30MP0003937_abnormal_limbs/digits/tail_de1.57405447
31MP0003077_abnormal_cell_cycle1.53433003
32MP0000566_synostosis1.51070793
33MP0003136_yellow_coat_color1.50723675
34MP0006072_abnormal_retinal_apoptosis1.50299166
35MP0008057_abnormal_DNA_replication1.47988865
36MP0006036_abnormal_mitochondrial_physio1.47911179
37MP0003283_abnormal_digestive_organ1.41501747
38MP0002160_abnormal_reproductive_system1.39057507
39MP0002084_abnormal_developmental_patter1.38379529
40MP0009672_abnormal_birth_weight1.36400076
41MP0002233_abnormal_nose_morphology1.35904907
42MP0003123_paternal_imprinting1.31262414
43MP0009379_abnormal_foot_pigmentation1.30927010
44MP0001485_abnormal_pinna_reflex1.28331696
45MP0002102_abnormal_ear_morphology1.27588158
46MP0003786_premature_aging1.24373012
47MP0006292_abnormal_olfactory_placode1.22981610
48MP0003195_calcinosis1.22851546
49MP0005395_other_phenotype1.22774336
50MP0009703_decreased_birth_body1.22035084
51MP0002085_abnormal_embryonic_tissue1.19460333
52MP0000579_abnormal_nail_morphology1.15930714
53MP0006035_abnormal_mitochondrial_morpho1.11934834
54MP0001529_abnormal_vocalization1.10447064
55MP0010234_abnormal_vibrissa_follicle1.08788217
56MP0001929_abnormal_gametogenesis1.07877083
57MP0002111_abnormal_tail_morphology1.07456339
58MP0005377_hearing/vestibular/ear_phenot1.05743857
59MP0003878_abnormal_ear_physiology1.05743857
60MP0001730_embryonic_growth_arrest1.05299284
61MP0005623_abnormal_meninges_morphology1.04976254
62MP0002734_abnormal_mechanical_nocicepti1.02944604
63MP0009780_abnormal_chondrocyte_physiolo1.02569368
64MP0002282_abnormal_trachea_morphology0.99796306
65MP0003567_abnormal_fetal_cardiomyocyte0.99445489
66MP0008995_early_reproductive_senescence0.97310783
67MP0002796_impaired_skin_barrier0.96415421
68MP0005253_abnormal_eye_physiology0.95173125
69MP0003121_genomic_imprinting0.93157822
70MP0005220_abnormal_exocrine_pancreas0.92706225
71MP0005075_abnormal_melanosome_morpholog0.92534741
72MP0002736_abnormal_nociception_after0.91358625
73MP0000350_abnormal_cell_proliferation0.91216711
74MP0003787_abnormal_imprinting0.88738781
75MP0001286_abnormal_eye_development0.87589457
76MP0003011_delayed_dark_adaptation0.87242360
77MP0000358_abnormal_cell_content/0.87071332
78MP0002638_abnormal_pupillary_reflex0.85877148
79MP0009046_muscle_twitch0.85696541
80MP0003122_maternal_imprinting0.84921850
81MP0001324_abnormal_eye_pigmentation0.84804567
82MP0002090_abnormal_vision0.84399742
83MP0010678_abnormal_skin_adnexa0.83687669
84MP0010352_gastrointestinal_tract_polyps0.82109737
85MP0005380_embryogenesis_phenotype0.81393320
86MP0001672_abnormal_embryogenesis/_devel0.81393320
87MP0005636_abnormal_mineral_homeostasis0.81331545
88MP0003698_abnormal_male_reproductive0.79190019
89MP0002080_prenatal_lethality0.79032465
90MP0002938_white_spotting0.79023142
91MP0002909_abnormal_adrenal_gland0.78097782
92MP0001145_abnormal_male_reproductive0.77441062
93MP0001697_abnormal_embryo_size0.76897953
94MP0000653_abnormal_sex_gland0.75384735
95MP0000383_abnormal_hair_follicle0.74881089
96MP0002210_abnormal_sex_determination0.74041118
97MP0000631_abnormal_neuroendocrine_gland0.73815678
98MP0005551_abnormal_eye_electrophysiolog0.72299737
99MP0005389_reproductive_system_phenotype0.72259887
100MP0001177_atelectasis0.72008978

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.48321073
2Abnormal respiratory motile cilium morphology (HP:0005938)9.18810115
3Abnormal respiratory epithelium morphology (HP:0012253)9.18810115
4Abnormal ciliary motility (HP:0012262)9.06186708
5Rhinitis (HP:0012384)8.80237331
6Absent/shortened dynein arms (HP:0200106)8.73110320
7Dynein arm defect of respiratory motile cilia (HP:0012255)8.73110320
8Chronic bronchitis (HP:0004469)7.56116117
9Bronchiectasis (HP:0002110)6.30134108
10Nasal polyposis (HP:0100582)4.82930478
11Pancreatic fibrosis (HP:0100732)3.81318593
12Abnormality of the nasal mucosa (HP:0000433)3.77893596
13Bronchitis (HP:0012387)3.56568550
14Infertility (HP:0000789)3.55774678
15True hermaphroditism (HP:0010459)3.52412786
16Occipital encephalocele (HP:0002085)3.29551522
17Chronic sinusitis (HP:0011109)3.26730332
18Pancreatic cysts (HP:0001737)3.18775681
19Recurrent sinusitis (HP:0011108)3.14180290
20Abnormality of midbrain morphology (HP:0002418)2.85052316
21Molar tooth sign on MRI (HP:0002419)2.85052316
22Cystic liver disease (HP:0006706)2.73803236
23Recurrent otitis media (HP:0000403)2.73567428
24Nephronophthisis (HP:0000090)2.69227168
25Male infertility (HP:0003251)2.63121534
26Anencephaly (HP:0002323)2.45344860
27Postaxial foot polydactyly (HP:0001830)2.27686809
28Medial flaring of the eyebrow (HP:0010747)2.26648742
29Hyperactive renin-angiotensin system (HP:0000841)2.22912428
30Chronic otitis media (HP:0000389)2.21672545
31Abnormality of the labia minora (HP:0012880)2.21403074
32Abdominal situs inversus (HP:0003363)2.19026705
33Abnormality of abdominal situs (HP:0011620)2.19026705
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.14712860
35Male pseudohermaphroditism (HP:0000037)2.14166932
36Aplasia/Hypoplasia of the spleen (HP:0010451)2.03313365
37Asplenia (HP:0001746)2.02996616
38Tubulointerstitial nephritis (HP:0001970)2.02332542
39Congenital primary aphakia (HP:0007707)2.02035846
40Sclerocornea (HP:0000647)2.01693289
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.6188790
42Supernumerary spleens (HP:0009799)1.96905125
43Chronic hepatic failure (HP:0100626)1.93774385
44Median cleft lip (HP:0000161)1.93320282
45Abnormality of the renal medulla (HP:0100957)1.92586512
46Gait imbalance (HP:0002141)1.91692352
47Acute necrotizing encephalopathy (HP:0006965)1.87820634
48Hyperinsulinemic hypoglycemia (HP:0000825)1.85904274
49Hypoglycemic seizures (HP:0002173)1.85395283
50Congenital hepatic fibrosis (HP:0002612)1.84899207
51Carpal bone hypoplasia (HP:0001498)1.82322779
52Furrowed tongue (HP:0000221)1.80857855
53Atelectasis (HP:0100750)1.79482347
54Nephrogenic diabetes insipidus (HP:0009806)1.76603818
55Oculomotor apraxia (HP:0000657)1.75765227
56Increased hepatocellular lipid droplets (HP:0006565)1.75698075
57Vaginal atresia (HP:0000148)1.75270548
58Genital tract atresia (HP:0001827)1.74003062
59Preaxial hand polydactyly (HP:0001177)1.73709662
60Acute encephalopathy (HP:0006846)1.70441451
61Postaxial hand polydactyly (HP:0001162)1.68965113
62Colon cancer (HP:0003003)1.65425339
63Septo-optic dysplasia (HP:0100842)1.56714877
64Facial cleft (HP:0002006)1.56601208
65Progressive macrocephaly (HP:0004481)1.56459879
66Abnormal mitochondria in muscle tissue (HP:0008316)1.56158449
67Mitochondrial inheritance (HP:0001427)1.55828276
68Lipid accumulation in hepatocytes (HP:0006561)1.54533541
69Tubular atrophy (HP:0000092)1.54186535
70Abnormal biliary tract physiology (HP:0012439)1.54181425
71Bile duct proliferation (HP:0001408)1.54181425
72Methylmalonic acidemia (HP:0002912)1.51405737
73Renal salt wasting (HP:0000127)1.48022890
74Poor coordination (HP:0002370)1.46038674
75Aplasia/Hypoplasia of the sacrum (HP:0008517)1.44234015
76Abnormality of methionine metabolism (HP:0010901)1.42061959
77Increased CSF lactate (HP:0002490)1.40107514
78Bilateral microphthalmos (HP:0007633)1.37383472
79Hyperglycinemia (HP:0002154)1.36248814
80Maternal diabetes (HP:0009800)1.33221069
81Cerebral edema (HP:0002181)1.32271751
82Central scotoma (HP:0000603)1.30465324
83Abnormality of homocysteine metabolism (HP:0010919)1.30382657
84Homocystinuria (HP:0002156)1.30382657
85Decreased activity of mitochondrial respiratory chain (HP:0008972)1.30368559
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.30368559
87Abnormality of serum amino acid levels (HP:0003112)1.30337252
88Hepatocellular necrosis (HP:0001404)1.30288528
89Hypoplastic female external genitalia (HP:0012815)1.29121296
90Abnormality of permanent molar morphology (HP:0011071)1.28617474
91Abnormality of the dental root (HP:0006486)1.28617474
92Taurodontia (HP:0000679)1.28617474
93Nephropathy (HP:0000112)1.28445764
94Abolished electroretinogram (ERG) (HP:0000550)1.28399958
95Methylmalonic aciduria (HP:0012120)1.28219535
96Broad foot (HP:0001769)1.27980203
97Hyperglycinuria (HP:0003108)1.26290261
98Megaloblastic anemia (HP:0001889)1.25974558
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.25033481
100Abnormality of macular pigmentation (HP:0008002)1.24702712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.46342516
2MAPK155.15570274
3TTK3.68455879
4PBK3.00354717
5TSSK62.99073385
6NME12.98062358
7CDC72.96938236
8BUB12.76903614
9STK162.64987869
10VRK22.46052846
11TNIK2.39133984
12SRPK12.33369850
13MKNK22.32879342
14PLK32.07118450
15ACVR1B1.82170432
16BRSK21.79793183
17WNK31.77725903
18PLK11.64510595
19ZAK1.61954877
20EIF2AK31.60188773
21STK241.58813796
22MKNK11.57532701
23TAF11.46551162
24CDK191.45957525
25PASK1.41362689
26BMPR1B1.38464472
27PLK41.38051905
28EPHA21.36785259
29STK38L1.31321166
30TRIM281.28976941
31VRK11.27144520
32NLK1.18169211
33MAP4K21.17127057
34DYRK31.16865002
35DYRK21.14480859
36EIF2AK11.13474305
37WEE11.12394119
38OXSR11.08324257
39PNCK1.06995397
40PAK40.98469565
41MAP3K120.94695955
42GRK10.93484138
43NUAK10.93177579
44BCR0.89207912
45FRK0.85026055
46CSNK1G10.83722091
47NEK10.77090970
48CHEK20.74801240
49ERBB30.73881924
50STK40.73321306
51CSNK1G20.68872507
52FGFR20.67753502
53STK100.66180225
54AURKA0.64960587
55ATR0.62791910
56ALK0.62091664
57ERBB40.60873586
58PRKCI0.60166320
59MAPKAPK30.59569706
60ATM0.58986175
61AURKB0.57850831
62BRSK10.57070690
63PINK10.55435182
64NEK60.54502365
65SMG10.52751758
66STK30.49705343
67TLK10.47031771
68PTK2B0.46953529
69CSNK2A10.46910759
70PLK20.43739198
71CSNK1E0.43665292
72CSNK1G30.43174253
73CSNK2A20.43143497
74MAP3K80.43047605
75PRKDC0.41736304
76MAP3K20.41668985
77MAP3K40.39177411
78CHEK10.37395088
79EIF2AK20.36333585
80TGFBR10.36057269
81INSRR0.35658759
82CASK0.35616737
83LATS10.32965876
84PRKCG0.31502869
85FGFR10.30888766
86NME20.29767417
87RPS6KA50.27956715
88MAP3K100.27111501
89PAK10.26232798
90EGFR0.25884741
91DMPK0.25759432
92DYRK1A0.24127499
93CSNK1A10.23732900
94CDK30.23161803
95STK390.22993929
96ADRBK20.22779398
97CDK10.21699249
98ERBB20.20738811
99CDK20.20149005
100TIE10.19934061

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.01983150
2Huntingtons disease_Homo sapiens_hsa050162.89400523
3Mismatch repair_Homo sapiens_hsa034302.76392997
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.62464124
5Protein export_Homo sapiens_hsa030602.60353585
6Oxidative phosphorylation_Homo sapiens_hsa001902.56228307
7RNA polymerase_Homo sapiens_hsa030202.54539417
8Glutathione metabolism_Homo sapiens_hsa004802.38486378
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.24762896
10Parkinsons disease_Homo sapiens_hsa050122.16454866
11Chemical carcinogenesis_Homo sapiens_hsa052042.01607305
12Ribosome_Homo sapiens_hsa030101.97331030
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96679029
14DNA replication_Homo sapiens_hsa030301.95838792
15Homologous recombination_Homo sapiens_hsa034401.95215642
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88145681
17Non-homologous end-joining_Homo sapiens_hsa034501.82776589
18RNA transport_Homo sapiens_hsa030131.72204734
19Spliceosome_Homo sapiens_hsa030401.71991630
20beta-Alanine metabolism_Homo sapiens_hsa004101.67097863
21Phenylalanine metabolism_Homo sapiens_hsa003601.65465284
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.63111264
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63044657
24Basal transcription factors_Homo sapiens_hsa030221.58162728
25Vitamin B6 metabolism_Homo sapiens_hsa007501.57194206
26Histidine metabolism_Homo sapiens_hsa003401.55624546
27Pyruvate metabolism_Homo sapiens_hsa006201.54064561
28Tyrosine metabolism_Homo sapiens_hsa003501.50279012
29Nucleotide excision repair_Homo sapiens_hsa034201.49658550
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.45521416
31RNA degradation_Homo sapiens_hsa030181.43853312
32Alzheimers disease_Homo sapiens_hsa050101.43316256
33Propanoate metabolism_Homo sapiens_hsa006401.37743847
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36622544
35One carbon pool by folate_Homo sapiens_hsa006701.32073411
36Retinol metabolism_Homo sapiens_hsa008301.31593029
37Base excision repair_Homo sapiens_hsa034101.31006404
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27259013
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27159541
40Fanconi anemia pathway_Homo sapiens_hsa034601.24086057
41Purine metabolism_Homo sapiens_hsa002301.22643776
42Steroid biosynthesis_Homo sapiens_hsa001001.22242362
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20617318
44Pyrimidine metabolism_Homo sapiens_hsa002401.17903319
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17756246
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15489657
47Selenocompound metabolism_Homo sapiens_hsa004501.15173117
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14774761
49Caffeine metabolism_Homo sapiens_hsa002321.11653784
50Cell cycle_Homo sapiens_hsa041101.06809392
51Peroxisome_Homo sapiens_hsa041460.99093710
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.97366317
53Fatty acid degradation_Homo sapiens_hsa000710.96868783
54Vitamin digestion and absorption_Homo sapiens_hsa049770.95984775
55mRNA surveillance pathway_Homo sapiens_hsa030150.92898505
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91461636
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87278478
58Cardiac muscle contraction_Homo sapiens_hsa042600.86046851
59Tight junction_Homo sapiens_hsa045300.85363463
60Phototransduction_Homo sapiens_hsa047440.84658311
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83879131
62Folate biosynthesis_Homo sapiens_hsa007900.83358782
63Metabolic pathways_Homo sapiens_hsa011000.81225833
64Biosynthesis of amino acids_Homo sapiens_hsa012300.80465893
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80005797
66Fatty acid elongation_Homo sapiens_hsa000620.79362079
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77690042
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77053828
69Collecting duct acid secretion_Homo sapiens_hsa049660.74241164
70Carbon metabolism_Homo sapiens_hsa012000.73598280
71Oocyte meiosis_Homo sapiens_hsa041140.70184263
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66322845
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65927095
74Arginine and proline metabolism_Homo sapiens_hsa003300.64429603
75p53 signaling pathway_Homo sapiens_hsa041150.64323030
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59858081
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59348697
78Regulation of autophagy_Homo sapiens_hsa041400.55564461
79Linoleic acid metabolism_Homo sapiens_hsa005910.49030769
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.46399105
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45772234
82Starch and sucrose metabolism_Homo sapiens_hsa005000.45338663
83Basal cell carcinoma_Homo sapiens_hsa052170.45216457
84Butanoate metabolism_Homo sapiens_hsa006500.43018905
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.41948452
86Tryptophan metabolism_Homo sapiens_hsa003800.40778984
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40215244
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.38936752
89N-Glycan biosynthesis_Homo sapiens_hsa005100.37728508
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.35723991
91Wnt signaling pathway_Homo sapiens_hsa043100.35039468
92Sphingolipid metabolism_Homo sapiens_hsa006000.32528214
93Nicotine addiction_Homo sapiens_hsa050330.31628878
94Arachidonic acid metabolism_Homo sapiens_hsa005900.31118249
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30898540
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30270781
97Hippo signaling pathway_Homo sapiens_hsa043900.29942247
98TGF-beta signaling pathway_Homo sapiens_hsa043500.29707145
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28955911
100Hedgehog signaling pathway_Homo sapiens_hsa043400.27763582

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