C9ORF24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear- or perinuclear-localized protein with no predicted domains or similarity to other known proteins. Expression of this gene is induced during the differentiation of bronchial epithelial cells, and the encoded protein may play a role in ciliogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.43394684
2intraciliary transport (GO:0042073)8.00410148
3left/right pattern formation (GO:0060972)7.56920950
4cilium organization (GO:0044782)7.00826937
5cilium assembly (GO:0042384)6.93753352
6left/right axis specification (GO:0070986)6.87499658
7regulation of cilium movement (GO:0003352)6.57664086
8sperm capacitation (GO:0048240)6.09409195
9microtubule bundle formation (GO:0001578)6.06382386
10primary alcohol catabolic process (GO:0034310)5.54711823
11cellular component assembly involved in morphogenesis (GO:0010927)5.28564700
12microtubule-based movement (GO:0007018)5.28537108
13one-carbon compound transport (GO:0019755)5.17346978
14cilium morphogenesis (GO:0060271)5.13585768
15intra-S DNA damage checkpoint (GO:0031573)5.01958278
16ethanol metabolic process (GO:0006067)4.91484613
17vitamin transmembrane transport (GO:0035461)4.84285647
18sperm motility (GO:0030317)4.82021494
19cell projection assembly (GO:0030031)4.69926798
20centriole assembly (GO:0098534)4.60889975
21protein localization to cilium (GO:0061512)4.41341823
22diterpenoid biosynthetic process (GO:0016102)4.30643798
23glomerular epithelial cell development (GO:0072310)3.92614191
24nucleoside diphosphate phosphorylation (GO:0006165)3.92069360
25imidazole-containing compound metabolic process (GO:0052803)3.88986738
26peptidyl-lysine dimethylation (GO:0018027)3.85739063
27tolerance induction (GO:0002507)3.85129805
28ethanol oxidation (GO:0006069)3.84296855
29microtubule depolymerization (GO:0007019)3.82105681
30lung epithelium development (GO:0060428)3.81726603
31establishment of apical/basal cell polarity (GO:0035089)3.81175626
32regulation of microtubule-based movement (GO:0060632)3.69753805
33pyrimidine-containing compound transmembrane transport (GO:0072531)3.67566804
34negative regulation of inclusion body assembly (GO:0090084)3.62632831
35negative regulation of T cell differentiation in thymus (GO:0033085)3.61408843
36determination of left/right symmetry (GO:0007368)3.59226618
37negative regulation of immunoglobulin mediated immune response (GO:0002890)3.52042810
38negative regulation of B cell mediated immunity (GO:0002713)3.52042810
39cytoplasmic microtubule organization (GO:0031122)3.50456669
40regulation of interleukin-5 production (GO:0032674)3.44128154
41determination of bilateral symmetry (GO:0009855)3.44004782
42response to xenobiotic stimulus (GO:0009410)3.42638174
43negative regulation of JUN kinase activity (GO:0043508)3.37749458
44specification of symmetry (GO:0009799)3.37223990
45microtubule polymerization or depolymerization (GO:0031109)3.33680317
46establishment of monopolar cell polarity (GO:0061162)3.30832861
47establishment or maintenance of monopolar cell polarity (GO:0061339)3.30832861
48negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.24668826
49smoothened signaling pathway (GO:0007224)3.24028514
50regulation of germinal center formation (GO:0002634)3.20784121
51protein polyglutamylation (GO:0018095)3.14370190
52negative regulation of humoral immune response (GO:0002921)3.14205788
53regulation of ARF protein signal transduction (GO:0032012)3.13383932
54gas transport (GO:0015669)3.10504898
55positive regulation of tolerance induction (GO:0002645)3.08297804
56organelle assembly (GO:0070925)3.01315143
57terpenoid biosynthetic process (GO:0016114)3.00616389
58establishment of tissue polarity (GO:0007164)3.00186583
59establishment of planar polarity (GO:0001736)3.00186583
60axonemal dynein complex assembly (GO:0070286)22.6869501
61positive regulation of smoothened signaling pathway (GO:0045880)2.99747129
62retinoic acid metabolic process (GO:0042573)2.99381495
63microtubule-based process (GO:0007017)2.97848880
64carnitine metabolic process (GO:0009437)2.97403277
65regulation of interleukin-13 production (GO:0032656)2.94927546
66microtubule severing (GO:0051013)2.93746648
67regulation of cilium assembly (GO:1902017)2.78830613
68glutathione derivative biosynthetic process (GO:1901687)2.72697138
69glutathione derivative metabolic process (GO:1901685)2.72697138
70lateral ventricle development (GO:0021670)2.69313304
71regulation of autophagic vacuole assembly (GO:2000785)2.67844048
72asymmetric protein localization (GO:0008105)2.61460971
73retinal rod cell development (GO:0046548)2.55205556
74exogenous drug catabolic process (GO:0042738)2.54321818
75nonmotile primary cilium assembly (GO:0035058)2.54320573
76regulation of vacuole organization (GO:0044088)2.53591185
77primary alcohol metabolic process (GO:0034308)2.51090493
78sodium ion homeostasis (GO:0055078)2.50966409
79regulation of inclusion body assembly (GO:0090083)2.45189891
80lateral sprouting from an epithelium (GO:0060601)2.44574047
81retinol metabolic process (GO:0042572)2.42295283
82folic acid-containing compound biosynthetic process (GO:0009396)2.41303764
83multicellular organismal water homeostasis (GO:0050891)2.39124173
84centriole replication (GO:0007099)2.37529468
85regulation of smoothened signaling pathway (GO:0008589)2.36690488
86regulation of microtubule depolymerization (GO:0031114)2.36624636
87apical protein localization (GO:0045176)2.31159877
88negative regulation of cytosolic calcium ion concentration (GO:0051481)2.28437282
89excretion (GO:0007588)2.27988962
90CDP-diacylglycerol biosynthetic process (GO:0016024)2.27796960
91hydrogen peroxide biosynthetic process (GO:0050665)2.27772774
92oligosaccharide biosynthetic process (GO:0009312)2.24630194
93nucleotide phosphorylation (GO:0046939)2.23270689
94regulation of tolerance induction (GO:0002643)2.22697935
95cilium or flagellum-dependent cell motility (GO:0001539)19.1361915
96cilium movement (GO:0003341)17.7777638
97motile cilium assembly (GO:0044458)15.2669590
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)15.1715316
99epithelial cilium movement (GO:0003351)14.4901697
100ventricular system development (GO:0021591)10.1374737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse4.95434779
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.89034834
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.52639955
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.60092711
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.52580511
6GBX2_23144817_ChIP-Seq_PC3_Human2.99429888
7DROSHA_22980978_ChIP-Seq_HELA_Human2.97717481
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87368616
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.47411914
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17647300
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06271395
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.05882405
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04940624
14CTNNB1_20460455_ChIP-Seq_HCT116_Human1.97395578
15NR3C1_21868756_ChIP-Seq_MCF10A_Human1.83935522
16AHR_22903824_ChIP-Seq_MCF-7_Human1.77179864
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69323267
18SMAD4_21799915_ChIP-Seq_A2780_Human1.65489412
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.61752943
20AR_21572438_ChIP-Seq_LNCaP_Human1.61658275
21ARNT_22903824_ChIP-Seq_MCF-7_Human1.59659841
22STAT3_23295773_ChIP-Seq_U87_Human1.49607829
23FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.49466737
24CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.45980360
25PHF8_20622853_ChIP-Seq_HELA_Human1.45429700
26FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44796341
27TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43965792
28ETV1_20927104_ChIP-Seq_GIST48_Human1.41331808
29TCF4_23295773_ChIP-Seq_U87_Human1.37012462
30TP63_23658742_ChIP-Seq_EP156T_Human1.35593156
31PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.34709327
32LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34380770
33TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33088701
34HNFA_21074721_ChIP-Seq_CACO-2_Human1.32364431
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32164944
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31278367
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30877565
38SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30404018
39* SMC4_20622854_ChIP-Seq_HELA_Human1.29927436
40SMRT_27268052_Chip-Seq_Bcells_Human1.29445068
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27459572
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24365873
43STAT1_20625510_ChIP-Seq_HELA_Human1.22653116
44NFYA_21822215_ChIP-Seq_K562_Human1.22577267
45SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21446778
46TP53_18474530_ChIP-ChIP_U2OS_Human1.19804189
47TBL1_22424771_ChIP-Seq_293T_Human1.17966550
48NFYB_21822215_ChIP-Seq_K562_Human1.17594599
49BCAT_22108803_ChIP-Seq_LS180_Human1.16310266
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.16090295
51* TP63_22573176_ChIP-Seq_HFKS_Human1.15744356
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.15652319
53FUS_26573619_Chip-Seq_HEK293_Human1.13740504
54PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13215556
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12872362
56GATA1_19941826_ChIP-Seq_K562_Human1.12834227
57RBPJ_21746931_ChIP-Seq_IB4_Human1.11925348
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10436758
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08886985
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.08860297
61TCF4_22108803_ChIP-Seq_LS180_Human1.08330541
62CBX2_22325352_ChIP-Seq_293T-Rex_Human1.08313506
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06241293
64GATA3_24758297_ChIP-Seq_MCF-7_Human1.05701133
65GATA6_21074721_ChIP-Seq_CACO-2_Human1.04872917
66CBP_21632823_ChIP-Seq_H3396_Human1.04853317
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.04766820
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04409772
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03945992
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03768437
71LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03351606
72FOXA2_19822575_ChIP-Seq_HepG2_Human1.03307568
73GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03122235
74ERG_20517297_ChIP-Seq_VCAP_Human1.03026215
75TP53_16413492_ChIP-PET_HCT116_Human1.01423024
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98249435
77SMAD3_21741376_ChIP-Seq_HESCs_Human0.97548744
78SMAD3_21741376_ChIP-Seq_EPCs_Human0.96189372
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95685158
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95334658
81YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95254529
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94839772
83FOXA1_25552417_ChIP-Seq_VCAP_Human0.94591262
84AR_19668381_ChIP-Seq_PC3_Human0.94545186
85RUNX2_22187159_ChIP-Seq_PCA_Human0.94204220
86FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93641919
87KLF5_25053715_ChIP-Seq_YYC3_Human0.93116703
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92113125
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91035557
90SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90879281
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90540178
92P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90520013
93P300_19829295_ChIP-Seq_ESCs_Human0.89770822
94SOX2_21211035_ChIP-Seq_LN229_Gbm0.88744615
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.86036148
96CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84916042
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84537754
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84537754
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83491972
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83283509

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology9.82021931
2MP0005623_abnormal_meninges_morphology6.32853116
3MP0008875_abnormal_xenobiotic_pharmacok4.48849206
4MP0001984_abnormal_olfaction3.45017937
5MP0003879_abnormal_hair_cell3.40562258
6MP0002132_abnormal_respiratory_system3.36058166
7MP0002282_abnormal_trachea_morphology3.29614111
8MP0004133_heterotaxia3.03061102
9MP0001485_abnormal_pinna_reflex2.87367678
10MP0004043_abnormal_pH_regulation2.75927403
11MP0000383_abnormal_hair_follicle2.67978173
12MP0000566_synostosis2.59881034
13MP0009780_abnormal_chondrocyte_physiolo2.48786921
14MP0002277_abnormal_respiratory_mucosa2.25193407
15MP0008789_abnormal_olfactory_epithelium2.19387460
16MP0010030_abnormal_orbit_morphology2.12593764
17MP0010678_abnormal_skin_adnexa2.09880181
18MP0003878_abnormal_ear_physiology2.08303368
19MP0005377_hearing/vestibular/ear_phenot2.08303368
20MP0005394_taste/olfaction_phenotype1.81872348
21MP0005499_abnormal_olfactory_system1.81872348
22MP0002249_abnormal_larynx_morphology1.80496986
23MP0005423_abnormal_somatic_nervous1.70056505
24MP0004019_abnormal_vitamin_homeostasis1.63674604
25MP0000569_abnormal_digit_pigmentation1.57088805
26MP0009046_muscle_twitch1.49792655
27MP0003656_abnormal_erythrocyte_physiolo1.48089310
28MP0002734_abnormal_mechanical_nocicepti1.40979221
29MP0002638_abnormal_pupillary_reflex1.37560595
30MP0000026_abnormal_inner_ear1.33488296
31MP0002909_abnormal_adrenal_gland1.21172405
32MP0003806_abnormal_nucleotide_metabolis1.19151689
33MP0001765_abnormal_ion_homeostasis1.15781513
34MP0001293_anophthalmia1.05722172
35MP0002233_abnormal_nose_morphology1.05407557
36MP0003890_abnormal_embryonic-extraembry1.04448197
37MP0002160_abnormal_reproductive_system1.04409962
38MP0002168_other_aberrant_phenotype1.03349095
39MP0001502_abnormal_circadian_rhythm1.02022927
40MP0003698_abnormal_male_reproductive1.00177320
41MP0001929_abnormal_gametogenesis0.94324443
42MP0000049_abnormal_middle_ear0.91333916
43MP0001346_abnormal_lacrimal_gland0.91249922
44MP0004264_abnormal_extraembryonic_tissu0.89988296
45MP0001963_abnormal_hearing_physiology0.88402148
46MP0005388_respiratory_system_phenotype0.88164413
47MP0002133_abnormal_respiratory_system0.88164413
48MP0002735_abnormal_chemical_nociception0.85426902
49MP0004270_analgesia0.82811437
50MP0009703_decreased_birth_body0.82642255
51MP0003937_abnormal_limbs/digits/tail_de0.81294104
52MP0005365_abnormal_bile_salt0.80514014
53MP0003136_yellow_coat_color0.80447260
54MP0004742_abnormal_vestibular_system0.79663757
55MP0005636_abnormal_mineral_homeostasis0.75931354
56MP0002332_abnormal_exercise_endurance0.74907015
57MP0001970_abnormal_pain_threshold0.73865855
58MP0002116_abnormal_craniofacial_bone0.70447239
59MP0005165_increased_susceptibility_to0.67498626
60MP0000678_abnormal_parathyroid_gland0.67027066
61MP0002229_neurodegeneration0.64759483
62MP0002089_abnormal_postnatal_growth/wei0.64375680
63MP0002084_abnormal_developmental_patter0.64032860
64MP0002928_abnormal_bile_duct0.62716830
65MP0005171_absent_coat_pigmentation0.62329371
66MP0005551_abnormal_eye_electrophysiolog0.61072788
67MP0000955_abnormal_spinal_cord0.61069434
68MP0003633_abnormal_nervous_system0.59220760
69MP0005395_other_phenotype0.58688858
70MP0001486_abnormal_startle_reflex0.58612684
71MP0000465_gastrointestinal_hemorrhage0.58611479
72MP0003861_abnormal_nervous_system0.58032707
73MP0005253_abnormal_eye_physiology0.57656694
74MP0001348_abnormal_lacrimal_gland0.57200286
75MP0008995_early_reproductive_senescence0.56996776
76MP0009643_abnormal_urine_homeostasis0.56727127
77MP0002876_abnormal_thyroid_physiology0.55734110
78MP0005248_abnormal_Harderian_gland0.55482075
79MP0002161_abnormal_fertility/fecundity0.53753346
80MP0002572_abnormal_emotion/affect_behav0.53539028
81MP0001756_abnormal_urination0.52700467
82MP0000432_abnormal_head_morphology0.51761918
83MP0001299_abnormal_eye_distance/0.51498811
84MP0002405_respiratory_system_inflammati0.51452792
85MP0001849_ear_inflammation0.50914160
86MP0002272_abnormal_nervous_system0.50473534
87MP0005391_vision/eye_phenotype0.50138937
88MP0003943_abnormal_hepatobiliary_system0.49997359
89MP0005083_abnormal_biliary_tract0.49903591
90MP0001324_abnormal_eye_pigmentation0.49627788
91MP0000681_abnormal_thyroid_gland0.48817797
92MP0004859_abnormal_synaptic_plasticity0.46672221
93MP0003634_abnormal_glial_cell0.43869301
94MP0010155_abnormal_intestine_physiology0.43785439
95MP0002557_abnormal_social/conspecific_i0.42613434
96MP0002136_abnormal_kidney_physiology0.42304168
97MP0008873_increased_physiological_sensi0.42126930
98MP0002092_abnormal_eye_morphology0.41803115
99MP0003303_peritoneal_inflammation0.41402209
100MP0002822_catalepsy0.40881438

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.95426762
2Absent/shortened dynein arms (HP:0200106)9.95426762
3Abnormal respiratory epithelium morphology (HP:0012253)9.49404180
4Abnormal respiratory motile cilium morphology (HP:0005938)9.49404180
5Chronic bronchitis (HP:0004469)8.11383069
6Nasal polyposis (HP:0100582)7.49507250
7Bronchiectasis (HP:0002110)6.93008891
8Abnormality of the nasal mucosa (HP:0000433)6.23816500
9Recurrent sinusitis (HP:0011108)5.55202531
10Occipital encephalocele (HP:0002085)5.13802539
11Bronchitis (HP:0012387)4.62556279
12Chronic hepatic failure (HP:0100626)4.28909365
13Recurrent otitis media (HP:0000403)4.17204353
14Pancreatic fibrosis (HP:0100732)4.12412980
15True hermaphroditism (HP:0010459)3.99611454
16Nephronophthisis (HP:0000090)3.40016789
17Molar tooth sign on MRI (HP:0002419)3.29228319
18Abnormality of midbrain morphology (HP:0002418)3.29228319
19Pancreatic cysts (HP:0001737)3.24992861
20Tubular atrophy (HP:0000092)3.21049350
21Chronic sinusitis (HP:0011109)3.18721391
22Cystic liver disease (HP:0006706)3.16175853
23Infertility (HP:0000789)3.05333841
24Bell-shaped thorax (HP:0001591)2.88053815
25Male infertility (HP:0003251)2.70787033
26Bile duct proliferation (HP:0001408)2.65375602
27Abnormal biliary tract physiology (HP:0012439)2.65375602
28Postaxial foot polydactyly (HP:0001830)2.62307287
29Abnormality of the renal medulla (HP:0100957)2.56851759
30Aplasia/Hypoplasia of the tongue (HP:0010295)2.43844516
31Atelectasis (HP:0100750)2.42287663
32Chronic otitis media (HP:0000389)2.42169771
33Congenital hepatic fibrosis (HP:0002612)2.32502694
34Anencephaly (HP:0002323)2.26520709
35Recurrent bronchitis (HP:0002837)2.22737860
36Polydipsia (HP:0001959)2.18801438
37Abnormal drinking behavior (HP:0030082)2.18801438
38Oculomotor apraxia (HP:0000657)2.07692203
39Sclerocornea (HP:0000647)2.07440057
40Hyperactive renin-angiotensin system (HP:0000841)2.01866504
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.6492276
42Abnormal respiratory motile cilium physiology (HP:0012261)11.0646777
43Abnormal ciliary motility (HP:0012262)10.8454714
44Rhinitis (HP:0012384)10.0101406
45Medial flaring of the eyebrow (HP:0010747)1.99227904
46Tubulointerstitial nephritis (HP:0001970)1.97056817
47Furrowed tongue (HP:0000221)1.95820170
48Male pseudohermaphroditism (HP:0000037)1.90160953
49Congenital primary aphakia (HP:0007707)1.83919955
50Gait imbalance (HP:0002141)1.82081169
51Abnormality of the renal cortex (HP:0011035)1.76211650
52Postaxial hand polydactyly (HP:0001162)1.71392285
53Intellectual disability, moderate (HP:0002342)1.63813859
54Stage 5 chronic kidney disease (HP:0003774)1.60679284
55Nephrogenic diabetes insipidus (HP:0009806)1.59766892
56Preaxial hand polydactyly (HP:0001177)1.59405517
57Nephropathy (HP:0000112)1.59139098
58Optic nerve coloboma (HP:0000588)1.52617058
59Median cleft lip (HP:0000161)1.46803461
60Anophthalmia (HP:0000528)1.39725505
61Polyuria (HP:0000103)1.39186273
62Genital tract atresia (HP:0001827)1.38239563
63Narrow forehead (HP:0000341)1.34866652
64Poor coordination (HP:0002370)1.34360676
65Absent frontal sinuses (HP:0002688)1.32779962
66Vaginal atresia (HP:0000148)1.31377358
67Abnormality of renal excretion (HP:0011036)1.26166951
68Abnormal urine output (HP:0012590)1.22690512
69Portal hypertension (HP:0001409)1.19925984
70Asplenia (HP:0001746)1.18136427
71Abnormality of the distal phalanges of the toes (HP:0010182)1.17277654
72Renal salt wasting (HP:0000127)1.17089328
73Tubulointerstitial abnormality (HP:0001969)1.14655491
74Aplasia/Hypoplasia of the spleen (HP:0010451)1.14151943
75Prominent nasal bridge (HP:0000426)1.14100555
76Fetal akinesia sequence (HP:0001989)1.08473248
77Highly arched eyebrow (HP:0002553)1.08438304
78Abnormality of the hepatic vasculature (HP:0006707)1.08305031
79Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.07890892
80Aganglionic megacolon (HP:0002251)1.07355872
81Abnormality of permanent molar morphology (HP:0011071)1.06977232
82Abnormality of the dental root (HP:0006486)1.06977232
83Taurodontia (HP:0000679)1.06977232
84Short nail (HP:0001799)1.06640470
85Hyperkalemia (HP:0002153)1.06338282
86Decreased circulating renin level (HP:0003351)1.05243876
87Short thorax (HP:0010306)1.04977772
88Facial cleft (HP:0002006)0.99955762
89Abnormality of molar morphology (HP:0011070)0.97110187
90Abnormality of molar (HP:0011077)0.97110187
91Hyperaldosteronism (HP:0000859)0.96258621
92Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)0.95092027
93Long face (HP:0000276)0.94367674
94Abnormality of the dental pulp (HP:0006479)0.93353715
95Glucose intolerance (HP:0000833)0.91333769
96Bifid tongue (HP:0010297)0.91066298
97Aplasia/Hypoplasia of the sacrum (HP:0008517)0.90737345
98Abnormality of dentin (HP:0010299)0.89836548
99Full cheeks (HP:0000293)0.89759027
100Bifid scrotum (HP:0000048)0.89300379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.26496648
2EPHA23.40942679
3PTK2B3.30495149
4PNCK2.37623874
5MAPK1512.7225968
6MET1.94534630
7TLK11.62292157
8MAP3K21.56837831
9MAPKAPK31.52886102
10NME11.30349943
11STK241.30216113
12CSK1.26554787
13MAP3K41.26206163
14SMG11.21128448
15TTK1.17469028
16FGR1.13873415
17MAP3K121.12670050
18MUSK1.06802612
19NEK61.01609124
20PRKD31.01038149
21BMX0.95805190
22MAP3K30.93198079
23MAP2K70.91758372
24LRRK20.88954027
25TRPM70.88803266
26EEF2K0.82919507
27STK160.81147232
28MAP2K40.79529681
29STK390.78168332
30NTRK20.77847574
31TSSK60.77736034
32RET0.76177398
33EPHB10.75679539
34EPHA40.70458191
35WNK40.68769391
36ERBB20.66284581
37MARK20.64753929
38CAMK2G0.60472390
39BCR0.60407050
40CAMKK10.59246428
41CSF1R0.58138089
42CAMK40.57537720
43BRSK20.57068468
44SGK10.55988804
45NEK90.54958098
46MST1R0.54920237
47ROCK10.54267905
48PRKCI0.53837798
49RPS6KB20.51294810
50STK30.50953215
51STK100.50126628
52STK380.49305966
53SGK20.49080964
54MAPK130.47361953
55MAP3K70.46932254
56RPS6KA50.46064493
57EPHA30.43302541
58TESK10.42008824
59SGK4940.41787007
60SGK2230.41787007
61TBK10.39332631
62TAOK10.38026105
63AURKA0.37720123
64PRKCD0.37139138
65STK38L0.36718472
66FGFR20.36337438
67RIPK40.35923384
68LATS10.35841712
69MAPK100.35322568
70ERBB30.34156865
71PRKCQ0.33911712
72SGK30.33254351
73CAMK2A0.32380776
74PTK20.32038167
75CAMK1G0.31843796
76AKT20.31002587
77INSRR0.29717459
78PINK10.28233099
79CDK90.27814664
80PDGFRB0.27306514
81DYRK1B0.26652011
82RIPK10.26572485
83FGFR30.25051475
84PDPK10.24886335
85PRKCA0.24680222
86DYRK1A0.24261787
87PRKACA0.23577458
88MAPK70.22175970
89MAP3K60.21906751
90CDK50.21591304
91STK40.21244025
92PLK10.20213399
93PRKAA10.19724469
94RPS6KA30.18546787
95ABL10.17831780
96PRKD20.17386499
97PRKAA20.16016355
98MAPKAPK50.15789608
99CDK30.15122469
100IRAK10.15115328

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.12968567
2Phenylalanine metabolism_Homo sapiens_hsa003604.28193311
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.09219169
4Chemical carcinogenesis_Homo sapiens_hsa052044.03916621
5Histidine metabolism_Homo sapiens_hsa003403.98900339
6Huntingtons disease_Homo sapiens_hsa050163.73355210
7Tyrosine metabolism_Homo sapiens_hsa003503.42872406
8Systemic lupus erythematosus_Homo sapiens_hsa053222.84762963
9Glutathione metabolism_Homo sapiens_hsa004802.55821043
10beta-Alanine metabolism_Homo sapiens_hsa004102.53760081
11Alcoholism_Homo sapiens_hsa050342.18665549
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.08642153
13Nicotine addiction_Homo sapiens_hsa050332.01265504
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.91355968
15Retinol metabolism_Homo sapiens_hsa008301.83202235
16Caffeine metabolism_Homo sapiens_hsa002321.65365820
17One carbon pool by folate_Homo sapiens_hsa006701.59997515
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.50504027
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49633119
20Peroxisome_Homo sapiens_hsa041461.38398521
21Hedgehog signaling pathway_Homo sapiens_hsa043401.36269145
22ABC transporters_Homo sapiens_hsa020101.30600480
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.30051387
24Salivary secretion_Homo sapiens_hsa049701.25014107
25Linoleic acid metabolism_Homo sapiens_hsa005911.23564081
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16596023
27Sphingolipid metabolism_Homo sapiens_hsa006001.15721594
28Tight junction_Homo sapiens_hsa045301.14537825
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12599893
30Basal cell carcinoma_Homo sapiens_hsa052171.08619785
31Fatty acid degradation_Homo sapiens_hsa000711.05949450
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.03940575
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.03210603
34Cardiac muscle contraction_Homo sapiens_hsa042600.98378677
35Circadian rhythm_Homo sapiens_hsa047100.98222824
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91324073
37Propanoate metabolism_Homo sapiens_hsa006400.89880100
38Oxidative phosphorylation_Homo sapiens_hsa001900.87880716
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83229497
40Taste transduction_Homo sapiens_hsa047420.79508193
41Viral carcinogenesis_Homo sapiens_hsa052030.71716521
42Bile secretion_Homo sapiens_hsa049760.69124069
43Alzheimers disease_Homo sapiens_hsa050100.66734191
44GABAergic synapse_Homo sapiens_hsa047270.65440536
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64381348
46Glycerophospholipid metabolism_Homo sapiens_hsa005640.63114949
47cAMP signaling pathway_Homo sapiens_hsa040240.61032913
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60736667
49Arachidonic acid metabolism_Homo sapiens_hsa005900.60096200
50Dorso-ventral axis formation_Homo sapiens_hsa043200.58446930
51Hippo signaling pathway_Homo sapiens_hsa043900.56635127
52Olfactory transduction_Homo sapiens_hsa047400.54527645
53Collecting duct acid secretion_Homo sapiens_hsa049660.54426121
54Choline metabolism in cancer_Homo sapiens_hsa052310.54102368
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52891786
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51066930
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50767979
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50413157
59Starch and sucrose metabolism_Homo sapiens_hsa005000.48956315
60Notch signaling pathway_Homo sapiens_hsa043300.45865983
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43223682
62Metabolic pathways_Homo sapiens_hsa011000.42357623
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42246272
64PPAR signaling pathway_Homo sapiens_hsa033200.40354807
65Hepatitis C_Homo sapiens_hsa051600.39602421
66Arginine and proline metabolism_Homo sapiens_hsa003300.39577650
67Calcium signaling pathway_Homo sapiens_hsa040200.39522170
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.38482764
69Cocaine addiction_Homo sapiens_hsa050300.37956940
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35887841
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34493901
72Amphetamine addiction_Homo sapiens_hsa050310.34411730
73Pancreatic secretion_Homo sapiens_hsa049720.34199946
74Fatty acid biosynthesis_Homo sapiens_hsa000610.33105328
75Parkinsons disease_Homo sapiens_hsa050120.31969585
76Adherens junction_Homo sapiens_hsa045200.31708170
77Melanogenesis_Homo sapiens_hsa049160.31308493
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30584027
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29317310
80N-Glycan biosynthesis_Homo sapiens_hsa005100.28599496
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28196271
82Folate biosynthesis_Homo sapiens_hsa007900.28141189
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27984711
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24614416
85Wnt signaling pathway_Homo sapiens_hsa043100.23884449
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.23591093
87Complement and coagulation cascades_Homo sapiens_hsa046100.23100888
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22933013
89Gastric acid secretion_Homo sapiens_hsa049710.22372588
90Purine metabolism_Homo sapiens_hsa002300.21659325
91Morphine addiction_Homo sapiens_hsa050320.21424212
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21243944
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20501667
94Endocytosis_Homo sapiens_hsa041440.20409373
95Axon guidance_Homo sapiens_hsa043600.19068186
96Pyruvate metabolism_Homo sapiens_hsa006200.17881751
97Circadian entrainment_Homo sapiens_hsa047130.17449262
98Mineral absorption_Homo sapiens_hsa049780.16972543
99Glutamatergic synapse_Homo sapiens_hsa047240.15505807
100Amoebiasis_Homo sapiens_hsa051460.15005641

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