C9ORF40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.21306108
2mitotic chromosome condensation (GO:0007076)6.16611130
3DNA unwinding involved in DNA replication (GO:0006268)5.32122137
4maturation of SSU-rRNA (GO:0030490)5.16427053
5protein localization to chromosome, centromeric region (GO:0071459)5.04715983
6mitotic sister chromatid segregation (GO:0000070)5.03111255
7DNA topological change (GO:0006265)4.89923540
8sister chromatid segregation (GO:0000819)4.79497412
9mitotic metaphase plate congression (GO:0007080)4.73749445
10DNA strand elongation involved in DNA replication (GO:0006271)4.71994750
11DNA replication checkpoint (GO:0000076)4.64133653
12DNA strand elongation (GO:0022616)4.60917665
13viral transcription (GO:0019083)4.59498219
14telomere maintenance via semi-conservative replication (GO:0032201)4.55934290
15protein localization to kinetochore (GO:0034501)4.55513295
16kinetochore organization (GO:0051383)4.53273364
17heterochromatin organization (GO:0070828)4.45280713
18translational termination (GO:0006415)4.44413596
19chromatin remodeling at centromere (GO:0031055)4.37536588
20DNA synthesis involved in DNA repair (GO:0000731)4.26182632
21CENP-A containing nucleosome assembly (GO:0034080)4.25180449
22ribosomal small subunit assembly (GO:0000028)4.20955229
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.17517233
24mitotic sister chromatid cohesion (GO:0007064)4.03402804
25synapsis (GO:0007129)3.93621533
26metaphase plate congression (GO:0051310)3.92898809
27translational elongation (GO:0006414)3.86258256
28meiotic chromosome segregation (GO:0045132)3.80466595
29DNA replication initiation (GO:0006270)3.79427280
30chromosome organization involved in meiosis (GO:0070192)3.78932682
31telomere maintenance via recombination (GO:0000722)3.76864409
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.76318476
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.75800397
34cotranslational protein targeting to membrane (GO:0006613)3.72907083
35mitotic recombination (GO:0006312)3.69324006
36protein targeting to ER (GO:0045047)3.68792374
37ribonucleoprotein complex biogenesis (GO:0022613)3.67633021
38kinetochore assembly (GO:0051382)3.67437192
39protein localization to chromosome (GO:0034502)3.66129041
40cellular protein complex disassembly (GO:0043624)3.62920807
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.62673302
42chromosome segregation (GO:0007059)3.61582301
43chromosome condensation (GO:0030261)3.60860666
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.57774399
45nuclear pore complex assembly (GO:0051292)3.56679205
46translational initiation (GO:0006413)3.55650537
47histone exchange (GO:0043486)3.55189546
48DNA replication-independent nucleosome assembly (GO:0006336)3.54935481
49DNA replication-independent nucleosome organization (GO:0034724)3.54935481
50viral life cycle (GO:0019058)3.51275771
51establishment of chromosome localization (GO:0051303)3.51203616
52regulation of spindle organization (GO:0090224)3.47787691
53protein localization to endoplasmic reticulum (GO:0070972)3.47238013
54establishment of integrated proviral latency (GO:0075713)3.43460822
55protein complex disassembly (GO:0043241)3.37324077
56chromatin assembly or disassembly (GO:0006333)3.34567450
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.32590464
58DNA packaging (GO:0006323)3.28871391
59nucleotide-excision repair, DNA gap filling (GO:0006297)3.27202350
60formation of translation preinitiation complex (GO:0001731)3.26477936
61macromolecular complex disassembly (GO:0032984)3.21402580
62synaptonemal complex assembly (GO:0007130)3.21176545
63positive regulation of chromosome segregation (GO:0051984)3.20896032
64nuclear pore organization (GO:0006999)3.17327048
65deoxyribonucleotide biosynthetic process (GO:0009263)3.17209958
66chromatin assembly (GO:0031497)3.15301937
67regulation of chromosome segregation (GO:0051983)3.13258814
68ribosome biogenesis (GO:0042254)3.11366346
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10822539
70sister chromatid cohesion (GO:0007062)3.04926038
71ribosomal large subunit biogenesis (GO:0042273)3.03599268
72pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.02590040
73telomere maintenance via telomere lengthening (GO:0010833)3.01986573
74DNA replication-dependent nucleosome assembly (GO:0006335)2.99889084
75DNA replication-dependent nucleosome organization (GO:0034723)2.99889084
76purine nucleobase biosynthetic process (GO:0009113)2.98046372
77nucleobase biosynthetic process (GO:0046112)2.97244732
78ATP-dependent chromatin remodeling (GO:0043044)2.96826245
79regulation of helicase activity (GO:0051095)2.95653290
80resolution of meiotic recombination intermediates (GO:0000712)2.95134264
81mitotic nuclear envelope disassembly (GO:0007077)2.94526371
82negative regulation of chromosome segregation (GO:0051985)2.94028422
83rRNA processing (GO:0006364)2.93982238
84chromosome organization (GO:0051276)2.90881638
85spindle checkpoint (GO:0031577)2.90355246
86regulation of centrosome cycle (GO:0046605)2.88517148
87cellular component biogenesis (GO:0044085)2.87015880
88regulation of DNA endoreduplication (GO:0032875)2.86430412
89nucleobase-containing small molecule interconversion (GO:0015949)2.85191215
90negative regulation of sister chromatid segregation (GO:0033046)2.84464478
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84464478
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84464478
93negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84464478
94negative regulation of mitotic sister chromatid separation (GO:2000816)2.84464478
95regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84290524
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84290524
97pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.83654714
98translation (GO:0006412)2.83512730
99translesion synthesis (GO:0019985)2.81527490
100regulation of mitotic spindle organization (GO:0060236)2.80500832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.39862657
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.23471687
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.32785365
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.08027067
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.90306514
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65484399
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.45040839
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.02367030
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.91008477
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89780411
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86450584
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80827447
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73289743
14XRN2_22483619_ChIP-Seq_HELA_Human2.61364591
15AR_21909140_ChIP-Seq_LNCAP_Human2.57008139
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.53826504
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.53623143
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33347427
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20095390
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.18631167
21TTF2_22483619_ChIP-Seq_HELA_Human2.18474575
22DCP1A_22483619_ChIP-Seq_HELA_Human2.17558255
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.13775015
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.08891750
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05794685
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02729384
27ZFX_18555785_ChIP-Seq_MESCs_Mouse2.02220010
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.01883761
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98688425
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92928520
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89837011
32CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.76116655
33* GABP_19822575_ChIP-Seq_HepG2_Human1.76055362
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73586518
35* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63753243
36FOXP3_21729870_ChIP-Seq_TREG_Human1.59051874
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58666695
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57425389
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56544356
40MYC_22102868_ChIP-Seq_BL_Human1.54621290
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54207480
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47165697
43ZNF263_19887448_ChIP-Seq_K562_Human1.47068099
44KDM5A_27292631_Chip-Seq_BREAST_Human1.47013461
45CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.46244869
46E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.45219807
47CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.44569450
48KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43720867
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42981133
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42663055
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.42416797
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39452285
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36846816
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32226195
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31460914
56VDR_23849224_ChIP-Seq_CD4+_Human1.30329341
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29711850
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.28188375
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28003586
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27556614
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26046179
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23048783
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21142483
64* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19440665
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16224764
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14087979
67VDR_21846776_ChIP-Seq_THP-1_Human1.13224772
68CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11639488
69ELK1_19687146_ChIP-ChIP_HELA_Human1.11315584
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09222203
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08565577
72MYC_18940864_ChIP-ChIP_HL60_Human1.06616454
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03552858
74CIITA_25753668_ChIP-Seq_RAJI_Human1.01692901
75TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01329863
76ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97881383
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97340574
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96198525
79EGR1_19374776_ChIP-ChIP_THP-1_Human0.95056131
80ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94460691
81SOX2_16153702_ChIP-ChIP_HESCs_Human0.91140506
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90548708
83NANOG_21062744_ChIP-ChIP_HESCs_Human0.89085523
84TFEB_21752829_ChIP-Seq_HELA_Human0.88409298
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88268422
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87031366
87CHD1_26751641_Chip-Seq_LNCaP_Human0.86771271
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86150250
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85720027
90SRF_21415370_ChIP-Seq_HL-1_Mouse0.85082465
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83062566
92FOXP1_21924763_ChIP-Seq_HESCs_Human0.81198498
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.80746416
94TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80319504
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.78936256
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.78761729
97OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78429864
98SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78272381
99GATA1_26923725_Chip-Seq_HPCs_Mouse0.77302917
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.77160155

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.64738142
2MP0003111_abnormal_nucleus_morphology4.59132910
3MP0010094_abnormal_chromosome_stability4.07188042
4MP0002877_abnormal_melanocyte_morpholog3.73141571
5MP0004957_abnormal_blastocyst_morpholog3.69498069
6MP0003077_abnormal_cell_cycle3.48771587
7MP0009379_abnormal_foot_pigmentation3.37583359
8MP0008932_abnormal_embryonic_tissue3.23742785
9MP0008058_abnormal_DNA_repair3.13161835
10MP0006292_abnormal_olfactory_placode3.11119237
11MP0008057_abnormal_DNA_replication2.86959869
12MP0000350_abnormal_cell_proliferation2.14055850
13MP0001730_embryonic_growth_arrest1.91336731
14MP0003718_maternal_effect1.86519101
15MP0001188_hyperpigmentation1.84654120
16MP0003123_paternal_imprinting1.84197340
17MP0002210_abnormal_sex_determination1.80730380
18MP0008007_abnormal_cellular_replicative1.79024576
19MP0010030_abnormal_orbit_morphology1.71923267
20MP0005623_abnormal_meninges_morphology1.68778877
21MP0000678_abnormal_parathyroid_gland1.66734216
22MP0008877_abnormal_DNA_methylation1.65001628
23MP0001672_abnormal_embryogenesis/_devel1.63466640
24MP0005380_embryogenesis_phenotype1.63466640
25MP0001697_abnormal_embryo_size1.62843450
26MP0001346_abnormal_lacrimal_gland1.61112116
27MP0003315_abnormal_perineum_morphology1.60665532
28MP0002160_abnormal_reproductive_system1.55359064
29MP0002163_abnormal_gland_morphology1.51459487
30MP0000490_abnormal_crypts_of1.47794506
31MP0005499_abnormal_olfactory_system1.46148512
32MP0005394_taste/olfaction_phenotype1.46148512
33MP0008789_abnormal_olfactory_epithelium1.45962963
34MP0003786_premature_aging1.45675752
35MP0010307_abnormal_tumor_latency1.45400435
36MP0003984_embryonic_growth_retardation1.42203963
37MP0002085_abnormal_embryonic_tissue1.41560765
38MP0000313_abnormal_cell_death1.40563324
39MP0002080_prenatal_lethality1.40252334
40MP0001293_anophthalmia1.39332733
41MP0001145_abnormal_male_reproductive1.38286963
42MP0001929_abnormal_gametogenesis1.35979631
43MP0002088_abnormal_embryonic_growth/wei1.33690425
44MP0006035_abnormal_mitochondrial_morpho1.31951020
45MP0009697_abnormal_copulation1.31100565
46MP0000653_abnormal_sex_gland1.25004879
47MP0002234_abnormal_pharynx_morphology1.24165462
48MP0002697_abnormal_eye_size1.23758879
49MP0002084_abnormal_developmental_patter1.19206219
50MP0000049_abnormal_middle_ear1.19000479
51MP0005084_abnormal_gallbladder_morpholo1.18702000
52MP0002249_abnormal_larynx_morphology1.17561503
53MP0009672_abnormal_birth_weight1.17424770
54MP0005501_abnormal_skin_physiology1.16643287
55MP0000537_abnormal_urethra_morphology1.14370876
56MP0003890_abnormal_embryonic-extraembry1.13026697
57MP0005408_hypopigmentation1.12864576
58MP0004185_abnormal_adipocyte_glucose1.09891674
59MP0003942_abnormal_urinary_system1.08545532
60MP0004147_increased_porphyrin_level1.06731097
61MP0004197_abnormal_fetal_growth/weight/1.05384032
62MP0005389_reproductive_system_phenotype1.03572084
63MP0000566_synostosis1.03040130
64MP0000358_abnormal_cell_content/1.01382090
65MP0002092_abnormal_eye_morphology1.00571794
66MP0000631_abnormal_neuroendocrine_gland1.00535415
67MP0003861_abnormal_nervous_system0.98056615
68MP0003698_abnormal_male_reproductive0.97970679
69MP0003186_abnormal_redox_activity0.97959867
70MP0001286_abnormal_eye_development0.94943634
71MP0002233_abnormal_nose_morphology0.94914035
72MP0009053_abnormal_anal_canal0.94258918
73MP0003656_abnormal_erythrocyte_physiolo0.94178046
74MP0001919_abnormal_reproductive_system0.93142717
75MP0008995_early_reproductive_senescence0.91574567
76MP0000428_abnormal_craniofacial_morphol0.91465578
77MP0002111_abnormal_tail_morphology0.90446361
78MP0002086_abnormal_extraembryonic_tissu0.88138818
79MP0008260_abnormal_autophagy0.87947918
80MP0000462_abnormal_digestive_system0.86581101
81MP0002161_abnormal_fertility/fecundity0.86422901
82MP0002095_abnormal_skin_pigmentation0.85259259
83MP0003937_abnormal_limbs/digits/tail_de0.84970366
84MP0005076_abnormal_cell_differentiation0.83910256
85MP0003121_genomic_imprinting0.83312659
86MP0005451_abnormal_body_composition0.82959294
87MP0006036_abnormal_mitochondrial_physio0.81107074
88MP0003119_abnormal_digestive_system0.80572608
89MP0002019_abnormal_tumor_incidence0.79108691
90MP0005187_abnormal_penis_morphology0.75445148
91MP0001270_distended_abdomen0.74185180
92MP0009703_decreased_birth_body0.73585222
93MP0001529_abnormal_vocalization0.72051998
94MP0003755_abnormal_palate_morphology0.71579401
95MP0003699_abnormal_female_reproductive0.70160975
96MP0001119_abnormal_female_reproductive0.69773636
97MP0005360_urolithiasis0.69709328
98MP0010352_gastrointestinal_tract_polyps0.67126270
99MP0005384_cellular_phenotype0.66636785
100MP0002938_white_spotting0.66630282

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.69318161
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.33821675
3Chromsome breakage (HP:0040012)4.31999791
4Aplasia/Hypoplasia of the sacrum (HP:0008517)4.31170457
5Abnormality of cells of the erythroid lineage (HP:0012130)4.00506415
6Birth length less than 3rd percentile (HP:0003561)3.85157898
7Macrocytic anemia (HP:0001972)3.83829862
8Abnormal number of erythroid precursors (HP:0012131)3.32795198
9Pallor (HP:0000980)3.10717182
10Breast hypoplasia (HP:0003187)2.95552064
11Abnormality of reticulocytes (HP:0004312)2.84653098
12Horseshoe kidney (HP:0000085)2.78988978
13Squamous cell carcinoma (HP:0002860)2.69171911
14Ectopic kidney (HP:0000086)2.63459252
15Abnormality of chromosome stability (HP:0003220)2.59609681
16Abnormality of the phalanges of the hallux (HP:0010057)2.56520476
17Meckel diverticulum (HP:0002245)2.56395125
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.53175679
19Increased nuchal translucency (HP:0010880)2.52151641
2011 pairs of ribs (HP:0000878)2.50973685
21Abnormality of the preputium (HP:0100587)2.50970044
22Duplication of thumb phalanx (HP:0009942)2.48566604
23Short middle phalanx of the 5th finger (HP:0004220)2.48104161
24Absent thumb (HP:0009777)2.46530937
25Absent radius (HP:0003974)2.45458899
26Triphalangeal thumb (HP:0001199)2.43733737
27Progressive muscle weakness (HP:0003323)2.41293646
28Impulsivity (HP:0100710)2.40781622
29Abnormality of the ileum (HP:0001549)2.38362905
30Facial hemangioma (HP:0000329)2.32519879
31Rectal fistula (HP:0100590)2.32341342
32Rectovaginal fistula (HP:0000143)2.32341342
33Missing ribs (HP:0000921)2.31687366
34Absent forearm bone (HP:0003953)2.28354457
35Aplasia involving forearm bones (HP:0009822)2.28354457
36Broad distal phalanx of finger (HP:0009836)2.25649930
37Abnormal mitochondria in muscle tissue (HP:0008316)2.23268353
38Duodenal stenosis (HP:0100867)2.22157620
39Small intestinal stenosis (HP:0012848)2.22157620
40Abnormality of the labia minora (HP:0012880)2.21482927
41Acute necrotizing encephalopathy (HP:0006965)2.18332043
42Capillary hemangiomas (HP:0005306)2.16642398
43Abnormality of the astrocytes (HP:0100707)2.15681916
44Astrocytoma (HP:0009592)2.15681916
45Abnormality of the fetal cardiovascular system (HP:0010948)2.15052044
46Abnormal umbilical cord blood vessels (HP:0011403)2.15052044
47Single umbilical artery (HP:0001195)2.15052044
48Proximal placement of thumb (HP:0009623)2.12141465
49Overlapping toe (HP:0001845)2.11749823
50Partial duplication of the phalanx of hand (HP:0009999)2.10876741
51Oligodactyly (HP:0012165)2.10356864
52Atresia of the external auditory canal (HP:0000413)2.10041584
53Gout (HP:0001997)2.09726225
54High anterior hairline (HP:0009890)2.08872463
55Ependymoma (HP:0002888)2.07740517
56Patellar aplasia (HP:0006443)2.07614166
57Volvulus (HP:0002580)2.07602839
58Partial duplication of thumb phalanx (HP:0009944)2.07322298
59Multiple enchondromatosis (HP:0005701)2.07287564
60Septate vagina (HP:0001153)2.06519789
61Abnormality of chromosome segregation (HP:0002916)2.03071416
62Aplasia/Hypoplasia of the patella (HP:0006498)2.02988769
63Myelodysplasia (HP:0002863)2.01485828
64Abnormal lung lobation (HP:0002101)2.00352717
65Abnormality of cochlea (HP:0000375)1.99934674
66Acute encephalopathy (HP:0006846)1.99770488
67Cutaneous melanoma (HP:0012056)1.98717613
68Short thumb (HP:0009778)1.98299386
69Deviation of the thumb (HP:0009603)1.96712928
70Vaginal fistula (HP:0004320)1.96045808
71Abnormality of the anterior horn cell (HP:0006802)1.92168276
72Degeneration of anterior horn cells (HP:0002398)1.92168276
73Hypoplasia of the radius (HP:0002984)1.91659712
74Cafe-au-lait spot (HP:0000957)1.91156991
75Microretrognathia (HP:0000308)1.90159185
76Intestinal fistula (HP:0100819)1.88921489
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87694201
78Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87694201
79Microvesicular hepatic steatosis (HP:0001414)1.86796783
80Oligodactyly (hands) (HP:0001180)1.84810065
81Abnormality of the duodenum (HP:0002246)1.84410905
82Colon cancer (HP:0003003)1.82017545
83Abnormality of DNA repair (HP:0003254)1.80935626
84Deep palmar crease (HP:0006191)1.79865601
85Slender long bone (HP:0003100)1.79559728
86Abnormal number of incisors (HP:0011064)1.79189525
87Metaphyseal cupping (HP:0003021)1.78410589
88Microglossia (HP:0000171)1.76905929
89Cortical dysplasia (HP:0002539)1.74848735
90Cerebral edema (HP:0002181)1.73145331
91Megaloblastic anemia (HP:0001889)1.72989844
92Abnormality of the umbilical cord (HP:0010881)1.69963007
93Rib fusion (HP:0000902)1.69048406
94Nephroblastoma (Wilms tumor) (HP:0002667)1.67807422
95Small epiphyses (HP:0010585)1.66235120
96Cleft eyelid (HP:0000625)1.61219290
97Embryonal renal neoplasm (HP:0011794)1.61127182
98Aplasia/Hypoplasia of the earlobes (HP:0009906)1.60667616
99Osteomalacia (HP:0002749)1.59376838
100Arteriovenous malformation (HP:0100026)1.59339907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.43301713
2CDC74.28057671
3TAF13.05501014
4TTK2.99419144
5NME22.68912136
6NEK12.58882500
7WEE12.58599733
8SRPK12.35405925
9PLK42.34144535
10VRK22.31945360
11BRAF2.29325293
12ARAF2.22279053
13EIF2AK12.15028456
14STK162.08697843
15BRSK12.02812753
16PNCK1.99455793
17AURKA1.95820750
18PLK11.91094709
19SMG11.86583833
20CHEK21.84035031
21MAP3K101.80348398
22NEK21.76102623
23PLK31.62494094
24VRK11.60214647
25AURKB1.58163186
26PBK1.55456898
27STK241.53273705
28ICK1.52770892
29ATR1.49113158
30PRKCI1.46992363
31STK41.43498167
32TRIM281.42339919
33BRSK21.37353534
34MAP3K91.36563724
35CDK71.32217370
36CHEK11.26941786
37CDK121.20329705
38STK31.17446881
39MAP3K81.16907797
40CDK81.08096489
41PRPF4B1.07605710
42CDK191.01277120
43MKNK20.98307928
44CDK40.97350366
45SCYL20.91977460
46PASK0.91868102
47ATM0.90355068
48ZAK0.90352455
49TAOK20.90268701
50CCNB10.83176709
51IRAK30.81730507
52DYRK30.80056162
53RPS6KB20.79244136
54* CDK20.77238977
55DMPK0.76027786
56TSSK60.75414296
57MKNK10.74115766
58CDK10.71820348
59CDK11A0.71115205
60EEF2K0.69452133
61RPS6KA40.68725392
62RPS6KA50.68472180
63CDK150.64217885
64CDK140.63417222
65CSNK2A20.62324509
66PAK10.61157411
67MOS0.61106474
68CDK180.60142778
69LATS10.58969504
70CSNK2A10.58779277
71CSNK1E0.56877695
72RAF10.55662229
73NUAK10.51725981
74TLK10.50867364
75CAMK1G0.49833600
76DYRK20.49730336
77KSR10.49318058
78MAP3K130.48714004
79CDK90.45273157
80KSR20.45164224
81LRRK20.44637084
82AKT20.44431444
83STK38L0.44212475
84ILK0.43556789
85BMX0.41100990
86PIM10.39275579
87PLK20.35657297
88MAP3K50.35049852
89PRKDC0.33820115
90MARK30.33174893
91MELK0.32872113
92ALK0.32697102
93STK100.32456703
94TRIB30.32035492
95PDK20.31290588
96PIM20.30189357
97WNK40.29310873
98MAP2K30.28419181
99CSNK1G30.27913102
100IRAK20.27779771

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.16041537
2Ribosome_Homo sapiens_hsa030104.39824293
3Mismatch repair_Homo sapiens_hsa034304.26974339
4Base excision repair_Homo sapiens_hsa034103.10624892
5Homologous recombination_Homo sapiens_hsa034403.05085539
6Cell cycle_Homo sapiens_hsa041103.02552610
7Nucleotide excision repair_Homo sapiens_hsa034202.69432062
8Spliceosome_Homo sapiens_hsa030402.53691187
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36650251
10Fanconi anemia pathway_Homo sapiens_hsa034602.29915975
11RNA transport_Homo sapiens_hsa030132.26460128
12Sulfur relay system_Homo sapiens_hsa041222.17744805
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14503631
14One carbon pool by folate_Homo sapiens_hsa006702.11394121
15Pyrimidine metabolism_Homo sapiens_hsa002402.01692815
16Folate biosynthesis_Homo sapiens_hsa007901.98262496
17Non-homologous end-joining_Homo sapiens_hsa034501.88174000
18RNA polymerase_Homo sapiens_hsa030201.75066037
19Proteasome_Homo sapiens_hsa030501.68295891
20Biosynthesis of amino acids_Homo sapiens_hsa012301.51651583
21Basal transcription factors_Homo sapiens_hsa030221.51368104
22Parkinsons disease_Homo sapiens_hsa050121.47202587
23mRNA surveillance pathway_Homo sapiens_hsa030151.47083769
24p53 signaling pathway_Homo sapiens_hsa041151.42342532
25RNA degradation_Homo sapiens_hsa030181.42269810
26Oocyte meiosis_Homo sapiens_hsa041141.30978412
27Oxidative phosphorylation_Homo sapiens_hsa001901.30309829
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.30076948
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29453682
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25978618
31Huntingtons disease_Homo sapiens_hsa050161.25093557
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21621043
33Systemic lupus erythematosus_Homo sapiens_hsa053221.20479650
34Alcoholism_Homo sapiens_hsa050341.13143288
35Purine metabolism_Homo sapiens_hsa002301.08828259
36Pyruvate metabolism_Homo sapiens_hsa006200.99700198
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99438116
38Carbon metabolism_Homo sapiens_hsa012000.98549248
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98547907
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97379585
41Basal cell carcinoma_Homo sapiens_hsa052170.94203430
42Pentose phosphate pathway_Homo sapiens_hsa000300.93958250
43Hedgehog signaling pathway_Homo sapiens_hsa043400.90416053
44Fructose and mannose metabolism_Homo sapiens_hsa000510.87611895
45Protein export_Homo sapiens_hsa030600.87251236
46Vitamin B6 metabolism_Homo sapiens_hsa007500.83971727
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.82487976
48Viral carcinogenesis_Homo sapiens_hsa052030.81580951
49Thyroid cancer_Homo sapiens_hsa052160.73633237
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73024478
51Bladder cancer_Homo sapiens_hsa052190.69446428
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68048280
53Galactose metabolism_Homo sapiens_hsa000520.67877990
54Alzheimers disease_Homo sapiens_hsa050100.67381122
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.65443018
56Non-small cell lung cancer_Homo sapiens_hsa052230.64434904
57N-Glycan biosynthesis_Homo sapiens_hsa005100.63947894
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62843954
59Arginine and proline metabolism_Homo sapiens_hsa003300.56150542
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55898812
61Pancreatic cancer_Homo sapiens_hsa052120.54873405
62Melanoma_Homo sapiens_hsa052180.54705867
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53203517
64Hippo signaling pathway_Homo sapiens_hsa043900.52463189
65Lysine degradation_Homo sapiens_hsa003100.50141880
66HTLV-I infection_Homo sapiens_hsa051660.49648878
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49090553
68Epstein-Barr virus infection_Homo sapiens_hsa051690.48980643
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47604513
70Sulfur metabolism_Homo sapiens_hsa009200.45764524
71Wnt signaling pathway_Homo sapiens_hsa043100.44428069
72Fatty acid elongation_Homo sapiens_hsa000620.43428848
73Chronic myeloid leukemia_Homo sapiens_hsa052200.42918460
74Glutathione metabolism_Homo sapiens_hsa004800.42257182
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40715199
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39206401
77Metabolic pathways_Homo sapiens_hsa011000.38652006
78Selenocompound metabolism_Homo sapiens_hsa004500.38301110
79MicroRNAs in cancer_Homo sapiens_hsa052060.37936489
80Notch signaling pathway_Homo sapiens_hsa043300.36438663
81mTOR signaling pathway_Homo sapiens_hsa041500.33956084
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33936209
83Colorectal cancer_Homo sapiens_hsa052100.33754948
84Small cell lung cancer_Homo sapiens_hsa052220.32590573
85Vitamin digestion and absorption_Homo sapiens_hsa049770.29243685
86AMPK signaling pathway_Homo sapiens_hsa041520.27412474
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26886812
88Glioma_Homo sapiens_hsa052140.25815130
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24763181
90Steroid biosynthesis_Homo sapiens_hsa001000.23701705
91Endometrial cancer_Homo sapiens_hsa052130.23470614
92Apoptosis_Homo sapiens_hsa042100.21924663
93Prostate cancer_Homo sapiens_hsa052150.21102891
94Herpes simplex infection_Homo sapiens_hsa051680.19308661
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18456545
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.16595859
97Propanoate metabolism_Homo sapiens_hsa006400.15471965
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14966659
99Renal cell carcinoma_Homo sapiens_hsa052110.13512547
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12681550

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